首页 > 最新文献

中华胃肠外科杂志最新文献

英文 中文
[Surgical treatment for slow transit constipation: total colectomy and subtotal colectomy]. 慢传输型便秘的手术治疗:全结肠切除术和次全结肠切除术。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20241114-00372
M Guo, W D Tong

Although the surgical treatment of slow transit constipation (STC) has been around for over a century, the choice of surgical method is still controversial. Specifically, the two most widely used operations in the world are total colectomy ileorectostomy (TC-IRA) and subtotal colectomy. Subtotal colectomy offers many methods for anastomosis, including ileocecal and cecorectal anastomoses and so on. Cecorectal anastomosis can be divided into two types: isoperistaltic anastomosis and antiperistaltic anastomosis. It is generally believed that total colectomy provides definitive effects but results in more severe postoperative diarrhea, while subtotal colectomy may reduce postoperative diarrhea but potentially increase the risk of constipation recurrence. Most studies of these surgical methods are retrospective small-sample studies with low-quality evidence. This is also one of the reasons for the lack of STC gold standard surgery in clinical practice. This paper discusses the selection of surgical methods for intractable slow transit constipation (STC) based on a review of literature published within the past 10 years, as well as our team's extensive 33-year experience in diagnosing and treating constipation surgically.

慢传输型便秘(STC)的手术治疗已有一个多世纪的历史,但手术方法的选择仍存在争议。具体来说,世界上使用最广泛的两种手术是全结肠切除术和次全结肠切除术。结肠次全切除术提供了多种吻合方式,包括回盲吻合术和结肠直肠吻合术等。结肠直肠吻合术可分为等蠕动吻合术和反蠕动吻合术两种。一般认为,全结肠切除术疗效确切,但术后腹泻更严重,而次全结肠切除术可减少术后腹泻,但可能增加便秘复发的风险。这些手术方法的大多数研究是回顾性的小样本研究,证据质量低。这也是临床上缺乏STC金标准手术的原因之一。本文在回顾近10年来发表的文献的基础上,结合我们团队33年来在便秘的外科诊断和治疗方面的丰富经验,讨论顽固性慢传输型便秘(STC)手术方法的选择。
{"title":"[Surgical treatment for slow transit constipation: total colectomy and subtotal colectomy].","authors":"M Guo, W D Tong","doi":"10.3760/cma.j.cn441530-20241114-00372","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20241114-00372","url":null,"abstract":"<p><p>Although the surgical treatment of slow transit constipation (STC) has been around for over a century, the choice of surgical method is still controversial. Specifically, the two most widely used operations in the world are total colectomy ileorectostomy (TC-IRA) and subtotal colectomy. Subtotal colectomy offers many methods for anastomosis, including ileocecal and cecorectal anastomoses and so on. Cecorectal anastomosis can be divided into two types: isoperistaltic anastomosis and antiperistaltic anastomosis. It is generally believed that total colectomy provides definitive effects but results in more severe postoperative diarrhea, while subtotal colectomy may reduce postoperative diarrhea but potentially increase the risk of constipation recurrence. Most studies of these surgical methods are retrospective small-sample studies with low-quality evidence. This is also one of the reasons for the lack of STC gold standard surgery in clinical practice. This paper discusses the selection of surgical methods for intractable slow transit constipation (STC) based on a review of literature published within the past 10 years, as well as our team's extensive 33-year experience in diagnosing and treating constipation surgically.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1248-1253"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modified endoscopic mucosal resection for the treatment of early gastrointestinal lesions]. 【改良内镜下粘膜切除术治疗早期胃肠道病变】。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20241022-00347
W F Chen, W H Wu, X P Zhang, W W Fan

Objective: To evaluate the clinical efficacy of modified endoscopic mucosal resection (EMR) in the management of early gastrointestinal lesions. Methods: Upon endoscopic identification of the lesion, normal saline is injected into the submucosa to establish a fluid cushion, which elevates the lesion's mucosa. Methylene blue may also be applied to improve visualization of the relationship between the submucosa and muscular layer. A snare with a tip diameter of 2-3 mm is utilized to circumferentially incise the mucosal layer at the lesion's edge, forming a circular groove. The snare is anchored within this groove, allowing for complete resection of the lesion in a single step. The procedure involves a slow and alternating technique of electrosurgical cutting and coagulation to minimize bleeding risks, while upward tension on the snare during cutting reduces perforation risks. Direct coagulation of exposed blood vessels is performed using the snare tip, and hemostatic clips are applied to larger defects; nylon sutures may be utilized for substantial wounds. Results: Between June 2015 and April 2024, modified EMR was performed on 65 patients with early gastrointestinal lesions at Dongguan Children's Hospital, Guangdong Medical University. The mean operative time was (15.2 ± 3.1) minutes, with a complete resection rate of 100% and negative margins confirmed. Postoperative complications included one case each of delayed bleeding and electrosurgical syndrome. The average cost of consumables was (1887.2±187.6) yuan. Follow-up colonoscopies at 3 and 6 months postoperatively indicated no recurrences. Conclusions: Modified EMR demonstrates a short operative time, high safety and efficacy, and reduced material costs in the treatment of early gastrointestinal mucosal lesions.

目的:评价改良内镜下粘膜切除术(EMR)治疗早期胃肠道病变的临床疗效。方法:内镜下发现病变后,将生理盐水注入粘膜下层,建立液体垫,提升病变黏膜。亚甲基蓝也可用于改善粘膜下层和肌肉层之间关系的可视化。使用尖端直径为2-3 mm的圈套在病变边缘向周切粘膜层,形成圆形凹槽。圈套固定在这个凹槽内,允许在一个步骤中完全切除病变。手术过程包括缓慢和交替的电切割和凝固技术,以尽量减少出血风险,而切割过程中圈套的向上张力可减少穿孔风险。使用圈套尖端直接凝固暴露的血管,并将止血夹应用于较大的缺陷;尼龙缝合线可用于实质性伤口。结果:2015年6月至2024年4月,我们对广东医科大学东莞儿童医院65例早期胃肠道病变患者进行了改良EMR。平均手术时间为(15.2±3.1)分钟,全切率100%,切缘阴性。术后并发症包括迟发性出血和电刀综合征各1例。耗材平均成本为(1887.2±187.6)元。术后3、6个月随访结肠镜检查未见复发。结论:改良EMR治疗早期胃肠道黏膜病变手术时间短,安全性和有效性高,降低了材料成本。
{"title":"[Modified endoscopic mucosal resection for the treatment of early gastrointestinal lesions].","authors":"W F Chen, W H Wu, X P Zhang, W W Fan","doi":"10.3760/cma.j.cn441530-20241022-00347","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20241022-00347","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the clinical efficacy of modified endoscopic mucosal resection (EMR) in the management of early gastrointestinal lesions. <b>Methods:</b> Upon endoscopic identification of the lesion, normal saline is injected into the submucosa to establish a fluid cushion, which elevates the lesion's mucosa. Methylene blue may also be applied to improve visualization of the relationship between the submucosa and muscular layer. A snare with a tip diameter of 2-3 mm is utilized to circumferentially incise the mucosal layer at the lesion's edge, forming a circular groove. The snare is anchored within this groove, allowing for complete resection of the lesion in a single step. The procedure involves a slow and alternating technique of electrosurgical cutting and coagulation to minimize bleeding risks, while upward tension on the snare during cutting reduces perforation risks. Direct coagulation of exposed blood vessels is performed using the snare tip, and hemostatic clips are applied to larger defects; nylon sutures may be utilized for substantial wounds. <b>Results:</b> Between June 2015 and April 2024, modified EMR was performed on 65 patients with early gastrointestinal lesions at Dongguan Children's Hospital, Guangdong Medical University. The mean operative time was (15.2 ± 3.1) minutes, with a complete resection rate of 100% and negative margins confirmed. Postoperative complications included one case each of delayed bleeding and electrosurgical syndrome. The average cost of consumables was (1887.2±187.6) yuan. Follow-up colonoscopies at 3 and 6 months postoperatively indicated no recurrences. <b>Conclusions:</b> Modified EMR demonstrates a short operative time, high safety and efficacy, and reduced material costs in the treatment of early gastrointestinal mucosal lesions.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1284-1287"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Several problems needing attention in the diagnosis and treatment of common perianal benign diseases]. 【常见肛周良性疾病诊治应注意的几个问题】。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20241012-00339
F Gao, C F Gao

Hemorrhoids, anal fissure, anal fistula and perianal abscess are the most common benign diseases around the anus, which obviously affect people's life and work, and need to be well diagnosed and treated. Based on damage control, the treatment principle is to eliminate relevant disease symptoms and protect the anal function at the same time. Perianal benign diseases are common and frequently occurring, which can be diagnosed and treated in many non-specialist hospitals. Therefore, there is great heterogeneity in the level of diagnosis and treatment, and related complications may occur due to iatrogenic factors such as the selection of treatment strategies, resulting in certain medical risks and subsequent passive treatment. Conservative treatment of internal hemorrhoids at degree I-II and acute anal fissure can achieve good results; internal hemorrhoids at degree III-IV, external hemorrhoids, anal fistula and perianal abscess can only be cured by surgery. The surgeon should pay attention to the protection of anal pad tissue and sphincter function to prevent serious complications such as postoperative anal stenosis and defecation dysfunction. It is imperative to accurately evaluate the specific clinical characteristics of each patient, formulate individualized treatment plans, and combine multiple treatment approaches.

痔疮、肛裂、肛瘘和肛周脓肿是肛门周围最常见的良性疾病,它明显影响人们的生活和工作,需要很好的诊断和治疗。以损害控制为基础,治疗原则是消除相关疾病症状,同时保护肛门功能。肛周良性疾病是常见病和多发病,在许多非专科医院均可诊断和治疗。因此,在诊疗水平上存在较大的异质性,并可能因治疗策略的选择等医源性因素出现相关并发症,造成一定的医疗风险和后续的被动治疗。保守治疗ⅰ~ⅱ度内痔及急性肛裂均可取得良好效果;III-IV度内痔、外痔、肛瘘、肛周脓肿只能通过手术治疗。术者应注意保护肛垫组织和括约肌功能,防止术后出现肛门狭窄、排便功能障碍等严重并发症。准确评估每位患者的具体临床特征,制定个体化治疗方案,多种治疗方法相结合,势在必行。
{"title":"[Several problems needing attention in the diagnosis and treatment of common perianal benign diseases].","authors":"F Gao, C F Gao","doi":"10.3760/cma.j.cn441530-20241012-00339","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20241012-00339","url":null,"abstract":"<p><p>Hemorrhoids, anal fissure, anal fistula and perianal abscess are the most common benign diseases around the anus, which obviously affect people's life and work, and need to be well diagnosed and treated. Based on damage control, the treatment principle is to eliminate relevant disease symptoms and protect the anal function at the same time. Perianal benign diseases are common and frequently occurring, which can be diagnosed and treated in many non-specialist hospitals. Therefore, there is great heterogeneity in the level of diagnosis and treatment, and related complications may occur due to iatrogenic factors such as the selection of treatment strategies, resulting in certain medical risks and subsequent passive treatment. Conservative treatment of internal hemorrhoids at degree I-II and acute anal fissure can achieve good results; internal hemorrhoids at degree III-IV, external hemorrhoids, anal fistula and perianal abscess can only be cured by surgery. The surgeon should pay attention to the protection of anal pad tissue and sphincter function to prevent serious complications such as postoperative anal stenosis and defecation dysfunction. It is imperative to accurately evaluate the specific clinical characteristics of each patient, formulate individualized treatment plans, and combine multiple treatment approaches.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1213-1220"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chinese expert consensus on pelvic floor biofeedback for anorectal dysfunction (2024 edition)]. [中国专家共识盆底生物反馈治疗肛肠功能障碍(2024版)]。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20240719-00252

Pelvic floor biofeedback is a major non-surgical treatment for anorectal dysfunction and has been recommended in several foreign guidelines. There is no consensus on the clinical practice of pelvic floor biofeedback in China currently. There are controversies in indications, contraindications and formulation of protocols. Launched by Pelvic Floor Medicine Specialty Committee of World Federation of Chinese Medicine Societies and Anorectal Branch of Chinese Medical Doctor Association, Chinese experts on this field were convened to write the Chinese expert consensus on pelvic floor biofeedback for anorectal dysfunction based on relevant references and combined the latest evidence and experts' clinical experience. This consensus recommends that before the use of pelvic floor biofeedback therapy, the patient's condition and pelvic floor function should be fully evaluated, and the guiding role of doctors and pelvic floor therapists should be emphasized to guide the standardized use of pelvic floor biofeedback therapy.

盆底生物反馈是肛肠功能障碍的一种主要的非手术治疗方法,在一些国外指南中被推荐。目前国内对骨盆底生物反馈的临床实践尚无共识。在适应症、禁忌症和方案制定方面存在争议。由世界中医药学会联合会盆底医学专业委员会和中国医师协会肛肠分会发起,召集本领域的中国专家,根据相关文献,结合最新证据和专家临床经验,撰写盆底生物反馈治疗肛肠功能障碍的中国专家共识。这一共识建议,在使用盆底生物反馈疗法前,应充分评估患者的病情和盆底功能,强调医生和盆底治疗师的指导作用,指导盆底生物反馈疗法的规范使用。
{"title":"[Chinese expert consensus on pelvic floor biofeedback for anorectal dysfunction (2024 edition)].","authors":"","doi":"10.3760/cma.j.cn441530-20240719-00252","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20240719-00252","url":null,"abstract":"<p><p>Pelvic floor biofeedback is a major non-surgical treatment for anorectal dysfunction and has been recommended in several foreign guidelines. There is no consensus on the clinical practice of pelvic floor biofeedback in China currently. There are controversies in indications, contraindications and formulation of protocols. Launched by Pelvic Floor Medicine Specialty Committee of World Federation of Chinese Medicine Societies and Anorectal Branch of Chinese Medical Doctor Association, Chinese experts on this field were convened to write the Chinese expert consensus on pelvic floor biofeedback for anorectal dysfunction based on relevant references and combined the latest evidence and experts' clinical experience. This consensus recommends that before the use of pelvic floor biofeedback therapy, the patient's condition and pelvic floor function should be fully evaluated, and the guiding role of doctors and pelvic floor therapists should be emphasized to guide the standardized use of pelvic floor biofeedback therapy.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1202-1212"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances and considerations for surgical treatment of horseshoe anal fistulas]. [马蹄形肛瘘手术治疗的进展及注意事项]。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20240927-00329
S H Zhan, L Dai, L Y Fan, B L Yang, P Zhu

Horseshoe anal fistula is one of the most challenging subtypes of complex anal fistulas, closely related to the failure of anal fistula surgery and postoperative recurrence. Accurate preoperative assessment, correct classification, and appropriate surgical plans are crucial for improving treatment efficacy. This article primarily explores the clinical classification of horseshoe anal fistulas and the applicability of mainstream surgical techniques in different types of horseshoe anal fistulas, focusing on their cure rates, recurrence rates, and fecal continence, to assist surgeons to make reasonable surgical plans when treating horseshoe anal fistulas.

马蹄形肛瘘是复杂肛瘘中最具挑战性的亚型之一,与肛瘘手术失败及术后复发密切相关。准确的术前评估、正确的手术分类、合理的手术方案是提高治疗效果的关键。本文主要探讨马蹄形肛瘘的临床分类及主流手术技术在不同类型马蹄形肛瘘中的适用性,重点探讨其治愈率、复发率和大便失禁情况,以帮助外科医生在治疗马蹄形肛瘘时制定合理的手术方案。
{"title":"[Advances and considerations for surgical treatment of horseshoe anal fistulas].","authors":"S H Zhan, L Dai, L Y Fan, B L Yang, P Zhu","doi":"10.3760/cma.j.cn441530-20240927-00329","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20240927-00329","url":null,"abstract":"<p><p>Horseshoe anal fistula is one of the most challenging subtypes of complex anal fistulas, closely related to the failure of anal fistula surgery and postoperative recurrence. Accurate preoperative assessment, correct classification, and appropriate surgical plans are crucial for improving treatment efficacy. This article primarily explores the clinical classification of horseshoe anal fistulas and the applicability of mainstream surgical techniques in different types of horseshoe anal fistulas, focusing on their cure rates, recurrence rates, and fecal continence, to assist surgeons to make reasonable surgical plans when treating horseshoe anal fistulas.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1227-1237"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chinese expert consensus on the examination and evaluation of chronic constipation (2024 edition)]. 【中国慢性便秘检查与评价专家共识(2024版)】。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20241107-00367

Chronic constipation is a common functional bowel disease, and its diagnosis is based on history and physical examination. Laboratory examination is important for determining the cause, type, severity and treatment effect of chronic constipation. At present, the commonly used workup of chronic constipation includes X-ray, magnetic resonance, pelvic floor ultrasound, neuroelectrophysiology and colorectal manometry, etc., which are recommended in many constipation diagnosis and treatment guidelines, but there has been no consensus on various examination indications, examination methods, judgment criteria and clinical value norms in detail. Led by the Anorectal Physicians Branch of the Chinese Medical Doctor Association, the editorial department of the Chinese Journal of Gastrointestinal Surgery convened domestic experts in related fields to summarize and sort out common laboratory examination methods for chronic constipation in combination with the latest evidence-based medical evidence at home and abroad, and conducted evidence quality assessment and recommendation strength classification according to the GRADE system. The Chinese Expert Consensus on the Examination and Evaluation of Chronic Constipation (2024 edition) was thus formed to help and guide the standardized examination in clinical practice and accurately interpret its clinical value.

慢性便秘是一种常见的功能性肠病,其诊断主要依据病史和体格检查。实验室检查对于确定慢性便秘的病因、类型、严重程度和治疗效果非常重要。目前,慢性便秘常用的检查方法有x线、磁共振、盆底超声、神经电生理、结直肠测压等,在很多便秘诊疗指南中都有推荐,但具体的各种检查适应症、检查方法、判断标准和临床价值规范尚未形成共识。由中华医师协会肛肠医师分会牵头,《中华胃肠外科杂志》编辑部召集国内相关领域专家,结合国内外最新循证医学证据,对慢性便秘常用的实验室检查方法进行总结整理,并按照GRADE体系进行证据质量评估和推荐强度分级。形成《中国慢性便秘检查与评价专家共识(2024版)》,帮助和指导临床规范化检查,准确解读其临床价值。
{"title":"[Chinese expert consensus on the examination and evaluation of chronic constipation (2024 edition)].","authors":"","doi":"10.3760/cma.j.cn441530-20241107-00367","DOIUrl":"10.3760/cma.j.cn441530-20241107-00367","url":null,"abstract":"<p><p>Chronic constipation is a common functional bowel disease, and its diagnosis is based on history and physical examination. Laboratory examination is important for determining the cause, type, severity and treatment effect of chronic constipation. At present, the commonly used workup of chronic constipation includes X-ray, magnetic resonance, pelvic floor ultrasound, neuroelectrophysiology and colorectal manometry, etc., which are recommended in many constipation diagnosis and treatment guidelines, but there has been no consensus on various examination indications, examination methods, judgment criteria and clinical value norms in detail. Led by the Anorectal Physicians Branch of the Chinese Medical Doctor Association, the editorial department of the Chinese Journal of Gastrointestinal Surgery convened domestic experts in related fields to summarize and sort out common laboratory examination methods for chronic constipation in combination with the latest evidence-based medical evidence at home and abroad, and conducted evidence quality assessment and recommendation strength classification according to the GRADE system. The Chinese Expert Consensus on the Examination and Evaluation of Chronic Constipation (2024 edition) was thus formed to help and guide the standardized examination in clinical practice and accurately interpret its clinical value.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1191-1201"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Single center study of short-term and 10-year efficacy of performing the Jinling procedure on 3 310 patients with refractory mixed constipation]. [单中心研究金陵法治疗3 310例难治性混合性便秘的短期和10年疗效]。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20241018-00344
L Ni, X B Feng, X Y Li, Y Yao, Z N Hang, J Jiang
<p><p><b>Objective:</b> To evaluate the safety, effectiveness, and long-term efficacy of the Jinling procedure for management of refractory mixed constipation. <b>Methods:</b> We prospectively collected clinical data of patients with refractory mixed constipation treated by the Jinling procedure in the Institute of General Surgery of our hospital from January 2007 to August 2023. Perioperative complications, effectiveness within 1 year of surgery (as assessed by the Wexner constipation score, gastrointestinal quality of life index, frequency of spontaneous defecation, rate of satisfactory defecation, body composition, serological indicators, defecography, anorectal manometry) and 10 years after surgery (as assessed by the Wexner constipation score, patient assessment of constipation symptom, SF-36 quality of life score, and questionnaire concerning satisfaction with defecation). <b>Results:</b> The study cohort comprised 3310 patients of mean age 44±15 years, including 653 men and 2657 women. The duration of constipation was 141±114 months. The 1-month, 3-month, 6-month, and 12-month follow-up rates were 98.07% (3246/3310), 95.11% (3148/3310), 93.38% (3091/3310), and 92.81% (3072/3310), respectively. Overall, 1100 patients had undergone surgery at least 10 years previously, 683 of whom completed the questionnaire, making the 10-year follow-up rate 62.09%. The overall incidence of postoperative complications was 21.99% (728/3310), mortality 0.45% (15/3310), and duration of postoperative hospital stay 12.5±5.4 days. Compared with preoperative values, Wexner scores decreased significantly from 1 to 12 months after surgery, whereas the gastrointestinal quality of life index scores had gradually increased by 3 months after surgery; both changes were statistically significant (both <i>P</i> < 0.001). The frequency of spontaneous defecation increased significantly to > five times/day 1 month after surgery, following which it decreased gradually with time, falling to two to five times/day by 6 months after surgery. All nutritional indicators returned to preoperative levels within 1 year except for that of inorganic salt, which did not change significantly. By 6-12 months after surgery, the proportions of rectocele, mucosal prolapse, internal rectal intussusception, visceral ptosis, perineal descent, pelvic floor spasm, and puborectalis syndrome assessed by defecography were all significantly lower than before surgery (all <i>P</i> < 0.05). By 3 months after surgery, the anal resting pressure, anal maximum systolic pressure, and anorectal depression had all returned to preoperative levels. Twelve months after surgery, the rectoanal inhibition reflex was stronger than that before surgery, whereas anal relaxation was less pronounced than that before surgery; these differences are statistically significant (both <i>P</i> < 0.05). The Wexner scores (7±2 vs. 21±6) and patient assessment of constipation symptoms scores (13±5 vs. 39±5) were significantly lower 1
目的:评价金陵手术治疗难治性混合性便秘的安全性、有效性和远期疗效。方法:前瞻性收集我院普外科2007年1月至2023年8月金陵手术治疗难治性混合便秘患者的临床资料。围手术期并发症、手术1年内疗效(以韦克斯纳便秘评分、胃肠生活质量指数、自然排便次数、排便满意率、体成分、血清学指标、排便造影、肛肠测压法评估)及术后10年疗效(以韦克斯纳便秘评分、患者便秘症状评估、SF-36生活质量评分、以及排便满意度问卷)。结果:研究队列包括3310例患者,平均年龄44±15岁,其中男性653例,女性2657例。便秘持续时间141±114个月。随访1个月、3个月、6个月、12个月,随访率分别为98.07%(3246/3310)、95.11%(3148/3310)、93.38%(3091/3310)、92.81%(3072/3310)。总体而言,1100例患者至少在10年前接受过手术,其中683例完成了问卷调查,10年随访率为62.09%。术后并发症总发生率为21.99%(728/3310),死亡率为0.45%(15/3310),住院时间12.5±5.4 d。与术前比较,术后1 ~ 12个月Wexner评分明显下降,术后3个月胃肠道生活质量指数评分逐渐升高;两项变化均有统计学意义(P < 0.001)。术后1个月自行排便次数显著增加至5次/天,之后随时间逐渐减少,至术后6个月降至2 ~ 5次/天。除无机盐指标无显著变化外,其他营养指标均在1年内恢复到术前水平。术后6 ~ 12个月,排便造影评估直肠前突、黏膜脱垂、直肠内肠套叠、内脏上睑下垂、会阴下降、盆底痉挛、耻骨直肠综合征的比例均显著低于术前(P < 0.05)。术后3个月,肛门静息压、肛门最大收缩压、肛肠凹陷均恢复到术前水平。术后12个月直肠肛管抑制反射较术前明显增强,肛门松弛反射较术前明显减弱;差异均有统计学意义(P < 0.05)。Wexner评分(7±2比21±6)和患者便秘症状评估评分(13±5比39±5)在金陵手术后10年显著低于术前。SF-36生活质量评分中身体功能(90±5比78±8)、身体功能中的角色限制(89±12比50±24)、身体疼痛(67±18比33±22)、情绪健康(63±23比48±30)、活力(71±11比31±13)、精神健康(71±10比30±10)、社会功能(69±17比26±15)和一般健康(79±9比35±12)的八个维度均有显著改善(均P < 0.001)。术后1年和10年总排便满意率分别为95.02%(2919/3072)和87.56%(598/683)。结论:金陵术是治疗难治性混合性便秘安全有效的方法,可改善长期排便功能和胃肠生活质量。
{"title":"[Single center study of short-term and 10-year efficacy of performing the Jinling procedure on 3 310 patients with refractory mixed constipation].","authors":"L Ni, X B Feng, X Y Li, Y Yao, Z N Hang, J Jiang","doi":"10.3760/cma.j.cn441530-20241018-00344","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20241018-00344","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To evaluate the safety, effectiveness, and long-term efficacy of the Jinling procedure for management of refractory mixed constipation. &lt;b&gt;Methods:&lt;/b&gt; We prospectively collected clinical data of patients with refractory mixed constipation treated by the Jinling procedure in the Institute of General Surgery of our hospital from January 2007 to August 2023. Perioperative complications, effectiveness within 1 year of surgery (as assessed by the Wexner constipation score, gastrointestinal quality of life index, frequency of spontaneous defecation, rate of satisfactory defecation, body composition, serological indicators, defecography, anorectal manometry) and 10 years after surgery (as assessed by the Wexner constipation score, patient assessment of constipation symptom, SF-36 quality of life score, and questionnaire concerning satisfaction with defecation). &lt;b&gt;Results:&lt;/b&gt; The study cohort comprised 3310 patients of mean age 44±15 years, including 653 men and 2657 women. The duration of constipation was 141±114 months. The 1-month, 3-month, 6-month, and 12-month follow-up rates were 98.07% (3246/3310), 95.11% (3148/3310), 93.38% (3091/3310), and 92.81% (3072/3310), respectively. Overall, 1100 patients had undergone surgery at least 10 years previously, 683 of whom completed the questionnaire, making the 10-year follow-up rate 62.09%. The overall incidence of postoperative complications was 21.99% (728/3310), mortality 0.45% (15/3310), and duration of postoperative hospital stay 12.5±5.4 days. Compared with preoperative values, Wexner scores decreased significantly from 1 to 12 months after surgery, whereas the gastrointestinal quality of life index scores had gradually increased by 3 months after surgery; both changes were statistically significant (both &lt;i&gt;P&lt;/i&gt; &lt; 0.001). The frequency of spontaneous defecation increased significantly to &gt; five times/day 1 month after surgery, following which it decreased gradually with time, falling to two to five times/day by 6 months after surgery. All nutritional indicators returned to preoperative levels within 1 year except for that of inorganic salt, which did not change significantly. By 6-12 months after surgery, the proportions of rectocele, mucosal prolapse, internal rectal intussusception, visceral ptosis, perineal descent, pelvic floor spasm, and puborectalis syndrome assessed by defecography were all significantly lower than before surgery (all &lt;i&gt;P&lt;/i&gt; &lt; 0.05). By 3 months after surgery, the anal resting pressure, anal maximum systolic pressure, and anorectal depression had all returned to preoperative levels. Twelve months after surgery, the rectoanal inhibition reflex was stronger than that before surgery, whereas anal relaxation was less pronounced than that before surgery; these differences are statistically significant (both &lt;i&gt;P&lt;/i&gt; &lt; 0.05). The Wexner scores (7±2 vs. 21±6) and patient assessment of constipation symptoms scores (13±5 vs. 39±5) were significantly lower 1","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1254-1260"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Somatic symptoms often comorbid with benign anorectal disorders: a study of their significance]. [躯体症状常与良性肛肠疾病共病:其意义的研究]。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20240918-00322
Z F Zhao, Q C Zhao

Benign anorectal diseases represent a prevalent and intricate category of gastrointestinal disorders, encompassing conditions such as anal fissures, fistulas, hemorrhoids, incontinence, pain, and defecation disorders. These conditions include both anatomical abnormalities and functional disorders. Some patients continue to experience discomfort such as perianal discomfort, perineal heaviness, defecation difficulties, and abdominal bloating even after anatomical issues have been addressed, severely impairing social functioning. Generally, colorectal surgeons have paid little attention to somatic symptom disorder (SSD). This article introduced the manifestation of SSD in benign anorectal diseases from a psychosomatic perspective, advocating for the establishment of a biopsychosocial medical model in the diagnosis and treatment of these conditions to enhance patient rehabilitation outcomes. It is recommended that when benign anal diseases coexist with psychological disorders, SSD treatment should be used as a prerequisite. Surgical treatment should be considered only after the improvement of psychological disorders and SSD.

良性肛肠疾病是一种普遍而复杂的胃肠道疾病,包括肛裂、瘘管、痔疮、尿失禁、疼痛和排便障碍等疾病。这些情况包括解剖异常和功能障碍。一些患者即使在解剖问题得到解决后,仍会出现肛周不适、会阴沉重、排便困难和腹胀等不适,严重影响社交功能。一般来说,结直肠外科医生很少关注躯体症状障碍(SSD)。本文从心身角度介绍了SSD在良性肛肠疾病中的表现,倡导在诊断和治疗中建立生物-心理-社会医学模式,以提高患者康复效果。建议当良性肛门疾病与心理障碍并存时,以SSD治疗为前提。只有在心理障碍和SSD改善后才能考虑手术治疗。
{"title":"[Somatic symptoms often comorbid with benign anorectal disorders: a study of their significance].","authors":"Z F Zhao, Q C Zhao","doi":"10.3760/cma.j.cn441530-20240918-00322","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20240918-00322","url":null,"abstract":"<p><p>Benign anorectal diseases represent a prevalent and intricate category of gastrointestinal disorders, encompassing conditions such as anal fissures, fistulas, hemorrhoids, incontinence, pain, and defecation disorders. These conditions include both anatomical abnormalities and functional disorders. Some patients continue to experience discomfort such as perianal discomfort, perineal heaviness, defecation difficulties, and abdominal bloating even after anatomical issues have been addressed, severely impairing social functioning. Generally, colorectal surgeons have paid little attention to somatic symptom disorder (SSD). This article introduced the manifestation of SSD in benign anorectal diseases from a psychosomatic perspective, advocating for the establishment of a biopsychosocial medical model in the diagnosis and treatment of these conditions to enhance patient rehabilitation outcomes. It is recommended that when benign anal diseases coexist with psychological disorders, SSD treatment should be used as a prerequisite. Surgical treatment should be considered only after the improvement of psychological disorders and SSD.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1238-1242"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Giant perianal verrucous epidermal nevus]. 巨大肛周疣状表皮痣。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20240801-00269
S B Huang, H Zhang, S Liu, Y F Liu, G Shi
{"title":"[Giant perianal verrucous epidermal nevus].","authors":"S B Huang, H Zhang, S Liu, Y F Liu, G Shi","doi":"10.3760/cma.j.cn441530-20240801-00269","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20240801-00269","url":null,"abstract":"","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1288-1290"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Follow-up study on screening for early colorectal cancer in Shipai, Dongguan City, China]. [中国东莞石牌地区早期结直肠癌筛查随访研究]。
Q3 Medicine Pub Date : 2024-12-25 DOI: 10.3760/cma.j.cn441530-20240423-00151
Q N Wu, Z Zhang, X H Kong
<p><p><b>Objective:</b> To examine follow-up data of different subgroups in order to further evaluate the performance and practical value of community colorectal cancer screening by detection of stool methylation syndecan-2 gene (m<i>SDC2</i>) among residents of Shipai Town, Dongguan City. <b>Methods:</b> This was an observational study. From May 2021 to February 2022, the Shipai Town government of Dongguan City completed screening for colorectal cancer by detection of stool m<i>SDC2</i> in 10,708 residents from 18 villages who had met the initial screening criteria and been selected using whole population sampling. From May 2022 to February 2023, the research group conducted follow-up of participants about one year after the initial screening. Residents in the gray zone according to the initial screening were followed up by colonoscopy. Additionally, 1,000 residents with negative results on the initial screening were randomly sampled to undergo colonoscopy. Stool m<i>SDC2</i> detection was performed again on residents who had had positive results on the initial screening, and colonoscopy was performed on those who again tested positive. Compliance with colonoscopy and detection of gastrointestinal lesions during follow-up were assessed in different subgroups. <b>Results:</b> Of the 438 residents in the gray zone on the initial screening, 155 underwent colonoscopy follow-up (colonoscopy compliance rate 35.4% [155/438]). These colonoscopies revealed that 27 (17.4%) of the participants had gastrointestinal lesions, including advanced adenomas in 22 cases (14.2%) and non-adenomatous polyps in two cases (3.2%). No colorectal carcinomas was identified. Of the 1, 000 randomly sampled residents with negative results on initial screening, 286 underwent colonoscopy follow-up (colonoscopy compliance rate 28.6% [286/1000]), These colonoscopies revealed that 11 (3.8%)of these individuals had gastrointestinal lesions, including three advanced adenomas (1.0%), five non-advanced adenomas (1.7%), one serrated adenoma or polyp (0.3%), and two non-adenomatous polyps (0.7%), but no colorectal carcinomas. Of the 821 residents who tested positive in the initial screening, 511 again underwent stool mSDC2 detection one year later (follow-up rate 62.2% [511/821]). Of these participants, 66 tested positive again (rate of 12.9% [66/511]), 39 (7.6%) of them in the gray zone, whereas 406(79.5%) tested negative. Forty-seven of the residents with positive results underwent colonoscopy (colonoscopy compliance rate 71.2% [47/66]), which revealed 36 (76.6%) gastrointestinal lesions, including 10 advanced adenomas (21.3%), nine non-advanced adenomas (19.1%) and 17 non-adenomatous polyps (36.2%). <b>Conclusion:</b> Stool m<i>SDC2</i> detection performs well as a screening tool. In our study, colorectal cancer or precancerous lesions were extremely rare in participants who tested negative on the initial screening. However, some of the participants who tested in the gray zone on ini
目的:探讨不同亚组随访资料,以进一步评价东莞市石牌镇居民粪便甲基化syndecan-2基因(mSDC2)检测社区大肠癌筛查的效果及实用价值。方法:观察性研究。2021年5月至2022年2月,东莞市石牌镇政府对符合初步筛查标准的18个村10708名居民进行了粪便mSDC2检测,完成了对结直肠癌的筛查。从2022年5月到2023年2月,研究小组在初步筛选后约一年对参与者进行了随访。在灰色地带的居民根据最初的筛选进行结肠镜检查。此外,随机抽取1000名初步筛查结果为阴性的居民进行结肠镜检查。对初步筛查呈阳性的居民再次进行粪便mSDC2检测,对再次检测呈阳性的居民进行结肠镜检查。在随访期间对不同亚组的结肠镜检查依从性和胃肠道病变检测进行评估。结果:初步筛查处于灰色地带的438名居民中,155人接受结肠镜随访,结肠镜依从率为35.4%[155/438]。这些结肠镜检查显示27例(17.4%)参与者有胃肠道病变,包括22例晚期腺瘤(14.2%)和2例非腺瘤性息肉(3.2%)。未发现结直肠癌。在1000名随机抽样的初筛阴性居民中,286人接受了结肠镜随访(结肠镜依从率28.6%[286/1000]),结肠镜检查结果显示,其中11人(3.8%)存在胃肠道病变,其中晚期腺瘤3人(1.0%),非晚期腺瘤5人(1.7%),锯齿状腺瘤或息肉1人(0.3%),非腺瘤性息肉2人(0.7%),但未发现结直肠癌。在821名首次筛查呈阳性的居民中,511名在一年后再次进行粪便mSDC2检测(随访率为62.2%[511/821])。在这些参与者中,66人再次检测为阳性(12.9%[66/511]),39人(7.6%)处于灰色地带,406人(79.5%)检测为阴性。结果阳性的47名居民行结肠镜检查(结肠镜检查依从率71.2%[47/66]),发现36例(76.6%)胃肠道病变,其中晚期腺瘤10例(21.3%),非晚期腺瘤9例(19.1%),非腺瘤性息肉17例(36.2%)。结论:粪便mSDC2检测是一种良好的筛查工具。在我们的研究中,在最初的筛查中呈阴性的参与者中,结直肠癌或癌前病变极为罕见。然而,一些在最初筛查时处于灰色区域的参与者有癌前结直肠癌病变,特别是晚期腺瘤,如果没有后续结肠镜检查,这些病变可能会被遗漏。值得注意的是,粪便mSDC2检测对初步筛查呈阳性的个体具有良好的随访价值。
{"title":"[Follow-up study on screening for early colorectal cancer in Shipai, Dongguan City, China].","authors":"Q N Wu, Z Zhang, X H Kong","doi":"10.3760/cma.j.cn441530-20240423-00151","DOIUrl":"10.3760/cma.j.cn441530-20240423-00151","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To examine follow-up data of different subgroups in order to further evaluate the performance and practical value of community colorectal cancer screening by detection of stool methylation syndecan-2 gene (m&lt;i&gt;SDC2&lt;/i&gt;) among residents of Shipai Town, Dongguan City. &lt;b&gt;Methods:&lt;/b&gt; This was an observational study. From May 2021 to February 2022, the Shipai Town government of Dongguan City completed screening for colorectal cancer by detection of stool m&lt;i&gt;SDC2&lt;/i&gt; in 10,708 residents from 18 villages who had met the initial screening criteria and been selected using whole population sampling. From May 2022 to February 2023, the research group conducted follow-up of participants about one year after the initial screening. Residents in the gray zone according to the initial screening were followed up by colonoscopy. Additionally, 1,000 residents with negative results on the initial screening were randomly sampled to undergo colonoscopy. Stool m&lt;i&gt;SDC2&lt;/i&gt; detection was performed again on residents who had had positive results on the initial screening, and colonoscopy was performed on those who again tested positive. Compliance with colonoscopy and detection of gastrointestinal lesions during follow-up were assessed in different subgroups. &lt;b&gt;Results:&lt;/b&gt; Of the 438 residents in the gray zone on the initial screening, 155 underwent colonoscopy follow-up (colonoscopy compliance rate 35.4% [155/438]). These colonoscopies revealed that 27 (17.4%) of the participants had gastrointestinal lesions, including advanced adenomas in 22 cases (14.2%) and non-adenomatous polyps in two cases (3.2%). No colorectal carcinomas was identified. Of the 1, 000 randomly sampled residents with negative results on initial screening, 286 underwent colonoscopy follow-up (colonoscopy compliance rate 28.6% [286/1000]), These colonoscopies revealed that 11 (3.8%)of these individuals had gastrointestinal lesions, including three advanced adenomas (1.0%), five non-advanced adenomas (1.7%), one serrated adenoma or polyp (0.3%), and two non-adenomatous polyps (0.7%), but no colorectal carcinomas. Of the 821 residents who tested positive in the initial screening, 511 again underwent stool mSDC2 detection one year later (follow-up rate 62.2% [511/821]). Of these participants, 66 tested positive again (rate of 12.9% [66/511]), 39 (7.6%) of them in the gray zone, whereas 406(79.5%) tested negative. Forty-seven of the residents with positive results underwent colonoscopy (colonoscopy compliance rate 71.2% [47/66]), which revealed 36 (76.6%) gastrointestinal lesions, including 10 advanced adenomas (21.3%), nine non-advanced adenomas (19.1%) and 17 non-adenomatous polyps (36.2%). &lt;b&gt;Conclusion:&lt;/b&gt; Stool m&lt;i&gt;SDC2&lt;/i&gt; detection performs well as a screening tool. In our study, colorectal cancer or precancerous lesions were extremely rare in participants who tested negative on the initial screening. However, some of the participants who tested in the gray zone on ini","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 12","pages":"1269-1275"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
中华胃肠外科杂志
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1