首页 > 最新文献

中华胃肠外科杂志最新文献

英文 中文
[Shanghai consensus on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy(2024 edition)]. [袖状胃切除术患者胃食管反流病诊治上海共识(2024 年版)]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240819-00290

Morbid obesity and its accompanying diseases have become one of the most serious public health problems warranting global effort and bariatric and metabolic surgery is still the most effective method for long-term weight control. Among all bariatric and metabolic procedures, sleeve gastrectomy is currently the most widely used, but it is not a perfect procedure. One of the most serious issues that this surgical procedure faces is the possibility of worsening existing or developing de novo gastroesophageal reflux disease after surgery. Moreover, there is currently a lack of high-level clinical trial evidence on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy. Therefore, initiated by four domestic bariatric and metabolic surgery centers, 41 experts with rich experience in bariatric and metabolic surgery and diagnosis and treatment of gastroesophageal reflux disease from China, Japan, and South Korea reached a consensus on the diagnosis and treatment of gastroesophageal reflux disease in sleeve gastrectomy patients using the Delphi method. There are a total of 59 consultation questions in this consensus, of which 44 have reached a consensus. We hope that this consensus can not only serve as a reference for clinical diagnosis and treatment, but also provide more possible directions for future high-quality clinical research.

病态肥胖及其伴随疾病已成为最严重的公共卫生问题之一,需要全球共同努力,而减肥和代谢手术仍然是长期控制体重的最有效方法。在所有减肥和代谢手术中,袖带胃切除术是目前应用最广泛的手术,但它并不是一种完美的手术。该手术面临的一个最严重的问题是,术后现有的或新发的胃食管反流病可能会恶化。此外,关于袖状胃切除术患者胃食管反流病的诊断和治疗,目前还缺乏高水平的临床试验证据。为此,由国内四家减重与代谢外科中心发起,来自中国、日本、韩国的41位在减重与代谢外科及胃食管反流病诊治方面具有丰富经验的专家,采用德尔菲法就袖状胃切除术患者胃食管反流病的诊治达成共识。该共识共有 59 个咨询问题,其中 44 个已达成共识。我们希望这份共识不仅能为临床诊断和治疗提供参考,也能为未来高质量的临床研究提供更多可能的方向。
{"title":"[Shanghai consensus on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy(2024 edition)].","authors":"","doi":"10.3760/cma.j.cn441530-20240819-00290","DOIUrl":"10.3760/cma.j.cn441530-20240819-00290","url":null,"abstract":"<p><p>Morbid obesity and its accompanying diseases have become one of the most serious public health problems warranting global effort and bariatric and metabolic surgery is still the most effective method for long-term weight control. Among all bariatric and metabolic procedures, sleeve gastrectomy is currently the most widely used, but it is not a perfect procedure. One of the most serious issues that this surgical procedure faces is the possibility of worsening existing or developing <i>de novo</i> gastroesophageal reflux disease after surgery. Moreover, there is currently a lack of high-level clinical trial evidence on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy. Therefore, initiated by four domestic bariatric and metabolic surgery centers, 41 experts with rich experience in bariatric and metabolic surgery and diagnosis and treatment of gastroesophageal reflux disease from China, Japan, and South Korea reached a consensus on the diagnosis and treatment of gastroesophageal reflux disease in sleeve gastrectomy patients using the Delphi method. There are a total of 59 consultation questions in this consensus, of which 44 have reached a consensus. We hope that this consensus can not only serve as a reference for clinical diagnosis and treatment, but also provide more possible directions for future high-quality clinical research.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"863-878"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lymph distant and skip metastasis of esophageal cancer based on the membrane anatomy theory]. [基于膜解剖理论的食管癌淋巴远处转移和跳过转移]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240710-00241
G J Wang

This study elaborates the essence of distant lymph node metastasis and skip metastasis of esophageal cancer according to the membrane anatomy theory. Lymph distant metastasis of esophageal cancer is essentially the phenomenon of cancer cells shedding from the primary focus of esophageal cancer and transferring along the direction of lymphatic drainage to the root of the esophageal mesentery. Because the metastasis is relatively distant, it is called distant metastasis. Despite the long distance, this metastasis is still limited to the envelope-like-membrane structure of the esophageal mesentery and belongs to the category of mesangial carcinoma. The lymph node skip metastasis of esophageal cancer refers to the process in which esophageal cancer cells detach from the primary lesion and migrate along the lymphatic drainage direction within the envelope-like-membrane structure of the mesentery to the central lymph nodes at the root of the mesentery. During this metastatic process, the surrounding mesenteric lymph nodes which are tightly attached to the esophagus will not be affected by cancer metastasis because of the isolation barrier effect of the envelope-like membrane structure of the esophageal mesentery. Applying the theory of membrane anatomy to esophageal cancer radical surgery will make the surgery more scientific, reasonable, and standardized, and is expected to achieve dual benefits of both surgical and oncological effects in esophageal cancer radical surgery.

本研究根据膜解剖学理论,阐述了食管癌远处淋巴结转移和跳淋巴结转移的本质。食管癌淋巴远处转移的本质是癌细胞从食管癌原发灶脱落,沿淋巴引流方向转移到食管系膜根部的现象。由于转移距离相对较远,因此称为远处转移。尽管距离较远,但这种转移仍局限于食管系膜的包膜样结构,属于系膜癌的范畴。食管癌的淋巴结跳过转移是指食管癌细胞脱离原发病灶,沿着系膜包膜样结构内的淋巴引流方向转移到系膜根部中央淋巴结的过程。在这一转移过程中,周围紧贴食管的肠系膜淋巴结由于食管系膜包膜样结构的隔离屏障作用,不会受到癌细胞转移的影响。将膜解剖学理论应用于食管癌根治术,将使手术更加科学、合理、规范,有望实现食管癌根治术的手术效果和肿瘤效果的双重效益。
{"title":"[Lymph distant and skip metastasis of esophageal cancer based on the membrane anatomy theory].","authors":"G J Wang","doi":"10.3760/cma.j.cn441530-20240710-00241","DOIUrl":"10.3760/cma.j.cn441530-20240710-00241","url":null,"abstract":"<p><p>This study elaborates the essence of distant lymph node metastasis and skip metastasis of esophageal cancer according to the membrane anatomy theory. Lymph distant metastasis of esophageal cancer is essentially the phenomenon of cancer cells shedding from the primary focus of esophageal cancer and transferring along the direction of lymphatic drainage to the root of the esophageal mesentery. Because the metastasis is relatively distant, it is called distant metastasis. Despite the long distance, this metastasis is still limited to the envelope-like-membrane structure of the esophageal mesentery and belongs to the category of mesangial carcinoma. The lymph node skip metastasis of esophageal cancer refers to the process in which esophageal cancer cells detach from the primary lesion and migrate along the lymphatic drainage direction within the envelope-like-membrane structure of the mesentery to the central lymph nodes at the root of the mesentery. During this metastatic process, the surrounding mesenteric lymph nodes which are tightly attached to the esophagus will not be affected by cancer metastasis because of the isolation barrier effect of the envelope-like membrane structure of the esophageal mesentery. Applying the theory of membrane anatomy to esophageal cancer radical surgery will make the surgery more scientific, reasonable, and standardized, and is expected to achieve dual benefits of both surgical and oncological effects in esophageal cancer radical surgery.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"904-908"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Distribution pattern of the rectal circumferential fascia and its clinical significance: An anatomical study]. [直肠周筋膜的分布模式及其临床意义:解剖学研究]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240710-00242
X J Wang, Y Deng, Z F Zheng, Y Huang, P Chi
<p><p><b>Objective:</b> To investigate the pattern of distribution of the circumferential fascia of the rectum and elucidate its clinical implications. <b>Methods:</b> In this descriptive study, we examined the gross anatomy of four male hemipelvic cadaveric specimens from the Department of Anatomy at Fujian Medical University and the histological features of 16 fresh postoperative specimens from patients who had undergone total mesorectal excision for rectal cancer at the Department of Colorectal Surgery, Union Hospital, Fujian Medical University, between January and December 2022. The resultant combination of gross anatomical and histological features was employed to assess the following areas: (1)the morphology of the anterior mesorectum and fascia at the peritoneal reflection; (2)the caudal attachment point of Denonvilliers' fascia; (3) the fusion area of the pelvic plexus and the pre-hypogastric fascia; (4)the lateral and posterior attachment edges of the rectosacral fascia; and (5) selected histological features. <b>Results:</b> Our findings were as follows. (1) At the peritoneal reflection, the anterior mesorectum forms a triangular fat pad with a dense fascial structure. The base of this pad extends anteriorly across the most caudal point of the peritoneal reflection, with Denonvilliers' fascia originating from the anterior side of the triangle, near the bladder side of the peritoneum craniad to the peritoneal reflection. (2) The caudal attachment of Denonvilliers' fascia is at the angle between the seminal vesicles, the ampulla of the vas deferens, and the prostate. It adheres tightly to the prostatic capsule and vascular bundles pass through its cephalic side. (3) The pre-hypogastric fascia transitions laterally to merge with Denonvilliers' fascia; its middle part being inseparable from the main body of the pelvic plexus, which gives rise to the nerves that innervate the rectum. (4) The rectosacral fascia is formed by fusion of the fascia propria with the pre-hypogastric fascia. The resultant fused fascia bifurcates into two leaves on the right side; the outer leaf being the pre-hypogastric fascia and the inner leaf the fascia propria. (5) Histologically, the peritoneal reflection zone shows cuboidal epithelium of the peritoneum at its lowest point with no detectable origin of Denonvilliers' fascia. The anterior side of the peritoneal reflection, from which Denonvilliers' fascia originates, has a dense double-layered fascial structure comprising thick collagen fiber (16/16). The fascia propria exhibits a thinner and looser collagen fiber structure and its origin varies between individuals, 13/16 originating together with Denonvilliers' fascia from the craniad side of the peritoneal reflection, and 3/16 originating separately from the most caudal point of the peritoneal reflection. The caudal edge of Denonvilliers' fascia has a double-layered fascial structure with multiple S100-stained areas. The posterior edge of the rectosacral fascia
研究目的研究直肠周缘筋膜的分布模式,并阐明其临床意义。方法在这项描述性研究中,我们对福建医科大学解剖学系的四具男性半骨盆尸体标本进行了大体解剖学检查,并对福建医科大学附属协和医院结直肠外科在 2022 年 1 月至 12 月期间接受直肠癌全直肠系膜切除术的 16 例新鲜术后标本进行了组织学特征检查。结合大体解剖学和组织学特征,对以下方面进行了评估:(1)直肠系膜前部和腹膜反射处筋膜的形态;(2)Denonvilliers筋膜的尾部附着点;(3)骨盆神经丛和下腹前筋膜的融合区;(4)直骶筋膜的外侧和后方附着边缘;以及(5)部分组织学特征。结果:我们的研究结果如下(1)在腹膜反射处,直肠系膜前部形成一个三角形脂肪垫,上面有致密的筋膜结构。该脂肪垫的基底向前方延伸,穿过腹膜反面的最尾端,Denonvilliers 筋膜起源于三角形的前侧,靠近腹膜反面前方的膀胱侧。(2)Denonvilliers 筋膜的尾部附着点位于精囊、输精管安瓿和前列腺之间的夹角处。它紧贴前列腺囊,血管束穿过其头侧。(3) 下腹前筋膜向侧方过渡,与德农维利耶筋膜合并;其中间部分与骨盆神经丛的主体密不可分,骨盆神经丛产生了支配直肠的神经。 (4) 直骶筋膜由固有筋膜与下腹前筋膜融合而成。融合后的筋膜在右侧分叉为两叶,外叶为下腹前筋膜,内叶为固有筋膜。(5)组织学上,腹膜反射区的最低点显示腹膜的立方上皮,没有发现德农维利耶筋膜的起源。腹膜反射区的前侧是 Denonvilliers 筋膜的发源地,有一个由厚胶原纤维(16/16)组成的致密双层筋膜结构。腹膜固有筋膜的胶原纤维结构更薄、更松散,其起源因个体而异,13/16 与 Denonvilliers 筋膜一起起源于腹膜反射的前侧,3/16 单独起源于腹膜反射的最尾端。Denonvilliers 筋膜的尾部边缘具有双层筋膜结构,并有多个 S100 染色区域。直骶筋膜后缘具有融合的筋膜结构,在高倍放大镜下可清楚地观察到来源于前胃筋膜的胶原纤维之间有粗大的神经纤维。直骶筋膜外侧边缘向内部延伸,保持了固有筋膜的完整性。结论:在这项研究中,我们通过尸体解剖和术后标本的组织学检查,研究了直肠周缘筋膜的分布模式。我们发现,直肠系膜前部形成了一个三角形脂肪垫,可作为在 Denonvilliers 筋膜前方解剖的参考,方法是在腹膜反光上方 1 厘米处切开。尾侧的 Denonvilliers 筋膜与前列腺囊融合区域有丰富的神经血管束,这与前列腺后平面的传统观点相悖。这一发现支持了在精囊底部上方 0.5 厘米处切开 Denonvilliers 筋膜的做法。固有筋膜与下腹前筋膜在后方融合形成直骶筋膜,直骶筋膜在直肠两侧分叉为两叶,内叶为固有筋膜,外叶为下腹前筋膜。这些筋膜向前方过渡成为德农维利耶筋膜,并与两侧骨盆神经丛的主体密集融合。这些发现为保护盆腔神经丛和胃下神经提供了理论依据,方法是横断 Denonvilliers 筋膜,然后从上到下(即从前方到尾部)解剖,最终导致横断前胃筋膜。
{"title":"[Distribution pattern of the rectal circumferential fascia and its clinical significance: An anatomical study].","authors":"X J Wang, Y Deng, Z F Zheng, Y Huang, P Chi","doi":"10.3760/cma.j.cn441530-20240710-00242","DOIUrl":"10.3760/cma.j.cn441530-20240710-00242","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the pattern of distribution of the circumferential fascia of the rectum and elucidate its clinical implications. &lt;b&gt;Methods:&lt;/b&gt; In this descriptive study, we examined the gross anatomy of four male hemipelvic cadaveric specimens from the Department of Anatomy at Fujian Medical University and the histological features of 16 fresh postoperative specimens from patients who had undergone total mesorectal excision for rectal cancer at the Department of Colorectal Surgery, Union Hospital, Fujian Medical University, between January and December 2022. The resultant combination of gross anatomical and histological features was employed to assess the following areas: (1)the morphology of the anterior mesorectum and fascia at the peritoneal reflection; (2)the caudal attachment point of Denonvilliers' fascia; (3) the fusion area of the pelvic plexus and the pre-hypogastric fascia; (4)the lateral and posterior attachment edges of the rectosacral fascia; and (5) selected histological features. &lt;b&gt;Results:&lt;/b&gt; Our findings were as follows. (1) At the peritoneal reflection, the anterior mesorectum forms a triangular fat pad with a dense fascial structure. The base of this pad extends anteriorly across the most caudal point of the peritoneal reflection, with Denonvilliers' fascia originating from the anterior side of the triangle, near the bladder side of the peritoneum craniad to the peritoneal reflection. (2) The caudal attachment of Denonvilliers' fascia is at the angle between the seminal vesicles, the ampulla of the vas deferens, and the prostate. It adheres tightly to the prostatic capsule and vascular bundles pass through its cephalic side. (3) The pre-hypogastric fascia transitions laterally to merge with Denonvilliers' fascia; its middle part being inseparable from the main body of the pelvic plexus, which gives rise to the nerves that innervate the rectum. (4) The rectosacral fascia is formed by fusion of the fascia propria with the pre-hypogastric fascia. The resultant fused fascia bifurcates into two leaves on the right side; the outer leaf being the pre-hypogastric fascia and the inner leaf the fascia propria. (5) Histologically, the peritoneal reflection zone shows cuboidal epithelium of the peritoneum at its lowest point with no detectable origin of Denonvilliers' fascia. The anterior side of the peritoneal reflection, from which Denonvilliers' fascia originates, has a dense double-layered fascial structure comprising thick collagen fiber (16/16). The fascia propria exhibits a thinner and looser collagen fiber structure and its origin varies between individuals, 13/16 originating together with Denonvilliers' fascia from the craniad side of the peritoneal reflection, and 3/16 originating separately from the most caudal point of the peritoneal reflection. The caudal edge of Denonvilliers' fascia has a double-layered fascial structure with multiple S100-stained areas. The posterior edge of the rectosacral fascia","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"919-927"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Learning curve for a five-step procedure, transthoracic single-port assisted laparoscopic transabdominal diaphragmatic approach, for Siewert type II adenocarcinoma of the esophagogastric junction]. [经胸单孔辅助腹腔镜经腹横膈膜入路治疗食管胃交界处 Siewert II 型腺癌五步手术的学习曲线]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240116-00028
H P Zeng, Y H Chen, L J Luo, Z J Zhang, Z Y Lin, Y Chen, Y H Peng, T Wang, Y S Zheng, W W Xiong, W Wang
<p><p><b>Objective:</b> To investigate the learning curve for a five-step procedure, namely, a transthoracic single-port assisted laparoscopic transabdominal diaphragmatic approach, for Siewert type II adenocarcinoma of the esophagogastric junction. <b>Methods:</b> In this retrospective cohort study, we analyzed relevant clinical data of 66 patients with Siewert type II adenocarcinoma of the esophagogastric junction who had undergone the five-step procedure performed by the same surgeon in the Gastrointestinal Surgery Department of Guangdong Provincial Hospital of Chinese Medicine from May 2017 to April 2023. The learning curve were plotted using cumulative summation analysis and selected indicators, including intraoperative blood loss, duration of surgery, time to first flatus, time to first tolerance of liquid food, length of hospital stay, and incidence of perioperative complications at different stages were compared. The data were analyzed using SPSS 24.0 statistical software. Numerical data are presented as cases (%) and data were analyzed using the χ<sup>2</sup> test or Fisher's exact test. Normally distributed measurement data are presented as <i>x±s</i>, and independent sample t-testing was performed for inter group comparison. Non-normally distributed measurement data are presented as <i>M</i>(<i>Q</i><sub>1</sub>, <i>Q</i><sub>3</sub>) and the Mann-Whitney U test was used for inter group comparison. <b>Results:</b> The five-step procedure had been successfully completed without switching to open surgery in all 66 study patients. There were no perioperative deaths, blood loss was 100 (50, 200) mL and duration of surgery 329.4±87.3 minutes. The equation of optimal fit for the duration of surgery was y=0.031x<sup>3</sup>-4.4757x<sup>2</sup>+164.97x-264.4 (<i>P</i><0.001, <i>R</i><sup>2</sup>=0.9797). The cumulative summation learning curve reached a vertex when 25 surgical procedures had accumulated. Using 25 cases as the cut-off, we divided the learning curves into learning and proficiency periods and patients into learning (25) and proficiency period groups (41). There were no statistically significant differences between the two groups of patients in sex, age, body mass index, American Society of Anesthesiologists score, history of abdominal surgery, comorbidities, preoperative neoadjuvant therapy, maximum tumor diameter, surgical procedure, or T and N stage of tumor (<i>P</i>>0.05). The following factors differed significantly (all <i>P</i><0.05) between the learning and proficiency stages: in the latter there was less intraoperative blood loss (100 [50, 100] ml vs. 200 [100, 200] ml, <i>U</i>=-3.940, <i>P</i><0.001), shorter duration of surgery ([289.8±50.7] minutes vs. [394.4±96.0] minutes, <i>t</i>=5.034, <i>P</i><0.001), more mediastinal lymph nodes removed (5 [2, 8] vs. 2 [1, 5], <i>U</i>=-2.518, <i>P</i>=0.012), earlier time to first flatus (2 [2, 3] days vs. 4 [3, 6] days, <i>U</i>=-4.016, <i>P</i><0.001), earlier time to first
目的研究经胸单孔辅助腹腔镜经腹膈肌入路治疗食管胃交界处 Siewert II 型腺癌五步手术的学习曲线。方法:在这项回顾性队列研究中,我们分析了2017年5月至2023年4月期间广东省中医院胃肠外科由同一外科医生实施五步手术的66例食管胃交界处Siewert II型腺癌患者的相关临床资料。采用累积求和分析法绘制学习曲线,并选取不同阶段的术中失血量、手术时间、首次排气时间、首次耐受流质食物时间、住院时间、围术期并发症发生率等指标进行比较。数据使用 SPSS 24.0 统计软件进行分析。数值数据以病例数(%)表示,数据分析采用χ2检验或费雪精确检验。正态分布的测量数据以 x±s 表示,组间比较采用独立样本 t 检验。非正态分布的测量数据以 M(Q1,Q3)表示,组间比较采用 Mann-Whitney U 检验。结果所有 66 名研究对象都成功完成了五步手术,没有改用开放手术。围手术期无死亡病例,失血量为 100(50,200)毫升,手术时间为(329.4±87.3)分钟。手术时间的最佳拟合方程为y=0.031x3-4.4757x2+164.97x-264.4(PR2=0.9797)。累计求和学习曲线在累计完成 25 例手术时达到顶点。以 25 例为分界线,我们将学习曲线分为学习期和熟练期,并将患者分为学习期组(25 例)和熟练期组(41 例)。两组患者在性别、年龄、体重指数、美国麻醉医师协会评分、腹部手术史、合并症、术前新辅助治疗、肿瘤最大直径、手术方式、肿瘤T期和N期等方面均无统计学差异(P>0.05)。以下因素有显著差异(全部PU=-3.940,Pt=5.034,PU=-2.518,P=0.012):首次排气时间更早(2 [2, 3] 天 vs. 4 [3, 6] 天,U=-4.016,PU=-2.922,P=0.003),住院时间更短(8 [8, 10] 天 vs. 10 [9, 12] 天,U=-2.028,P=0.043)。两组的手术并发症发生率无明显差异(P=0.238)。结论对食管胃交界处的 Siewert II 型腺癌患者采用五步手术法治疗食管胃交界处的腺癌,只要完成 25 次手术,就能取得满意的疗效。
{"title":"[Learning curve for a five-step procedure, transthoracic single-port assisted laparoscopic transabdominal diaphragmatic approach, for Siewert type II adenocarcinoma of the esophagogastric junction].","authors":"H P Zeng, Y H Chen, L J Luo, Z J Zhang, Z Y Lin, Y Chen, Y H Peng, T Wang, Y S Zheng, W W Xiong, W Wang","doi":"10.3760/cma.j.cn441530-20240116-00028","DOIUrl":"10.3760/cma.j.cn441530-20240116-00028","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the learning curve for a five-step procedure, namely, a transthoracic single-port assisted laparoscopic transabdominal diaphragmatic approach, for Siewert type II adenocarcinoma of the esophagogastric junction. &lt;b&gt;Methods:&lt;/b&gt; In this retrospective cohort study, we analyzed relevant clinical data of 66 patients with Siewert type II adenocarcinoma of the esophagogastric junction who had undergone the five-step procedure performed by the same surgeon in the Gastrointestinal Surgery Department of Guangdong Provincial Hospital of Chinese Medicine from May 2017 to April 2023. The learning curve were plotted using cumulative summation analysis and selected indicators, including intraoperative blood loss, duration of surgery, time to first flatus, time to first tolerance of liquid food, length of hospital stay, and incidence of perioperative complications at different stages were compared. The data were analyzed using SPSS 24.0 statistical software. Numerical data are presented as cases (%) and data were analyzed using the χ&lt;sup&gt;2&lt;/sup&gt; test or Fisher's exact test. Normally distributed measurement data are presented as &lt;i&gt;x±s&lt;/i&gt;, and independent sample t-testing was performed for inter group comparison. Non-normally distributed measurement data are presented as &lt;i&gt;M&lt;/i&gt;(&lt;i&gt;Q&lt;/i&gt;&lt;sub&gt;1&lt;/sub&gt;, &lt;i&gt;Q&lt;/i&gt;&lt;sub&gt;3&lt;/sub&gt;) and the Mann-Whitney U test was used for inter group comparison. &lt;b&gt;Results:&lt;/b&gt; The five-step procedure had been successfully completed without switching to open surgery in all 66 study patients. There were no perioperative deaths, blood loss was 100 (50, 200) mL and duration of surgery 329.4±87.3 minutes. The equation of optimal fit for the duration of surgery was y=0.031x&lt;sup&gt;3&lt;/sup&gt;-4.4757x&lt;sup&gt;2&lt;/sup&gt;+164.97x-264.4 (&lt;i&gt;P&lt;/i&gt;&lt;0.001, &lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=0.9797). The cumulative summation learning curve reached a vertex when 25 surgical procedures had accumulated. Using 25 cases as the cut-off, we divided the learning curves into learning and proficiency periods and patients into learning (25) and proficiency period groups (41). There were no statistically significant differences between the two groups of patients in sex, age, body mass index, American Society of Anesthesiologists score, history of abdominal surgery, comorbidities, preoperative neoadjuvant therapy, maximum tumor diameter, surgical procedure, or T and N stage of tumor (&lt;i&gt;P&lt;/i&gt;&gt;0.05). The following factors differed significantly (all &lt;i&gt;P&lt;/i&gt;&lt;0.05) between the learning and proficiency stages: in the latter there was less intraoperative blood loss (100 [50, 100] ml vs. 200 [100, 200] ml, &lt;i&gt;U&lt;/i&gt;=-3.940, &lt;i&gt;P&lt;/i&gt;&lt;0.001), shorter duration of surgery ([289.8±50.7] minutes vs. [394.4±96.0] minutes, &lt;i&gt;t&lt;/i&gt;=5.034, &lt;i&gt;P&lt;/i&gt;&lt;0.001), more mediastinal lymph nodes removed (5 [2, 8] vs. 2 [1, 5], &lt;i&gt;U&lt;/i&gt;=-2.518, &lt;i&gt;P&lt;/i&gt;=0.012), earlier time to first flatus (2 [2, 3] days vs. 4 [3, 6] days, &lt;i&gt;U&lt;/i&gt;=-4.016, &lt;i&gt;P&lt;/i&gt;&lt;0.001), earlier time to first ","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"938-944"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case report of ectopic small intestine and colon with absence of suspensory ligament of duodenum]. [十二指肠悬韧带缺失的异位小肠和结肠病例报告]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240112-00024
M X Zhang, B Q Liang, M E Li, C L Yang, R T Wei, Y Zhang, Y G Dai
{"title":"[A case report of ectopic small intestine and colon with absence of suspensory ligament of duodenum].","authors":"M X Zhang, B Q Liang, M E Li, C L Yang, R T Wei, Y Zhang, Y G Dai","doi":"10.3760/cma.j.cn441530-20240112-00024","DOIUrl":"10.3760/cma.j.cn441530-20240112-00024","url":null,"abstract":"","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"980-981"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical application of parasacral artery perforator flap in the treatment of Pilonidal Sinus Diseases]. [骶旁动脉穿孔器皮瓣在蝶窦疾病治疗中的临床应用]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20231017-00137
J H Lan, Z H Chen, Y Y Fan, L Han, T Wang, C Y Jia, W L He

Objective: To investigate clinical efficacy of parasacral perforator flap (PPF) on postoperative wound healing in pilonidal sinus diseases (PSDs). Methods: The surgery steps were as follows: (1) To preoperatively detect parasacral perforator arteries with the handhold Doppler probe and mark them; (2) To remove the infected and necrotic tissues of PSDs completely; (3) To design the PPF according to the wound size and the parasacral perforator arteries' localization; (4) To harvest the flap from the gluteus maximus muscle surface and transfer it to the wound without tension. Several data were documented, including surgical duration, flap length, flap width, drainage tube placement duration, hospital stay, duration from operation to stitch removal, postsurgical complications and recurrence. Results: There were six patients with PSDs whose postoperative wound healing was repaired by PPF, admitted in our department from March 2021 to March 2023. Of them, five were male and one was female. Their median age was 24 (range: 18-33) years old. Their median surgical duration was 165 (range: 134-207) minutes, median length of PPF was 8 (range: 7-11) cm, median width of PPF was 3 (range: 3-4) cm, mean duration of drainage tube placement was 8 (range: 4-17) days, mean hospital stay was 13 (range: 6-23) days, mean duration from operation to stitch removal was 14 (range: 14-17) days, median follow-up time was 6-16 months. Incisions of all six cases achieved first-intention healing without early- or late-stage complications. No recurrence occurred during follow-up. All patients involved were satisfied with their clinical efficacy. Conclusion: The utility of PPF in postoperative wound healing of PPDs was effective, safe and reliable.

目的研究骶骨旁穿孔器皮瓣(PPF)对朝天鼻窦疾病(PSD)术后伤口愈合的临床疗效。手术方法手术步骤如下:(1)术前用手持式多普勒探头检测骶骨旁穿孔动脉并标记;(2)彻底清除PSD感染和坏死组织;(3)根据创面大小和骶骨旁穿孔动脉定位设计PPF;(4)从臀大肌表面采集皮瓣并无张力转移至创面。记录了多项数据,包括手术时间、皮瓣长度、皮瓣宽度、引流管放置时间、住院时间、从手术到拆线的时间、术后并发症和复发情况。结果:2021 年 3 月至 2023 年 3 月期间,我科共收治了 6 名 PSD 患者,他们术后的伤口愈合都是通过 PPF 修复的。其中五名男性,一名女性。他们的中位年龄为 24 岁(18-33 岁)。手术时间中位数为 165 分钟(范围:134-207 分钟),PPF 长度中位数为 8 厘米(范围:7-11 厘米),PPF 宽度中位数为 3 厘米(范围:3-4 厘米),放置引流管的平均时间为 8 天(范围:4-17 天),平均住院时间为 13 天(范围:6-23 天),从手术到拆线的平均时间为 14 天(范围:14-17 天),随访时间中位数为 6-16 个月。所有六个病例的切口都达到了初愈效果,没有出现早期或晚期并发症。随访期间无复发。所有患者都对其临床疗效表示满意。结论PPF 在 PPD 术后伤口愈合中的应用是有效、安全和可靠的。
{"title":"[Clinical application of parasacral artery perforator flap in the treatment of Pilonidal Sinus Diseases].","authors":"J H Lan, Z H Chen, Y Y Fan, L Han, T Wang, C Y Jia, W L He","doi":"10.3760/cma.j.cn441530-20231017-00137","DOIUrl":"10.3760/cma.j.cn441530-20231017-00137","url":null,"abstract":"<p><p><b>Objective:</b> To investigate clinical efficacy of parasacral perforator flap (PPF) on postoperative wound healing in pilonidal sinus diseases (PSDs). <b>Methods:</b> The surgery steps were as follows: (1) To preoperatively detect parasacral perforator arteries with the handhold Doppler probe and mark them; (2) To remove the infected and necrotic tissues of PSDs completely; (3) To design the PPF according to the wound size and the parasacral perforator arteries' localization; (4) To harvest the flap from the gluteus maximus muscle surface and transfer it to the wound without tension. Several data were documented, including surgical duration, flap length, flap width, drainage tube placement duration, hospital stay, duration from operation to stitch removal, postsurgical complications and recurrence. <b>Results:</b> There were six patients with PSDs whose postoperative wound healing was repaired by PPF, admitted in our department from March 2021 to March 2023. Of them, five were male and one was female. Their median age was 24 (range: 18-33) years old. Their median surgical duration was 165 (range: 134-207) minutes, median length of PPF was 8 (range: 7-11) cm, median width of PPF was 3 (range: 3-4) cm, mean duration of drainage tube placement was 8 (range: 4-17) days, mean hospital stay was 13 (range: 6-23) days, mean duration from operation to stitch removal was 14 (range: 14-17) days, median follow-up time was 6-16 months. Incisions of all six cases achieved first-intention healing without early- or late-stage complications. No recurrence occurred during follow-up. All patients involved were satisfied with their clinical efficacy. <b>Conclusion:</b> The utility of PPF in postoperative wound healing of PPDs was effective, safe and reliable.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"970-973"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fascial anatomy of ligamentous structures associated with colon cancer surgery]. [结肠癌手术相关韧带结构的筋膜解剖]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240708-00237
X J Wang

The ligamentous structures integral to the surgical management of colon cancer include the gastrocolic ligament, the phrenicocolic ligament, and the splenocolic ligament. Historically, the era of conventional open surgery was characterized by the use of large forceps for clamping and ligating these ligaments. However, the advent of fascial and mesenteric anatomy research has ushered in a paradigm shift. Aided by high-definition laparoscopy, colorectal surgeons have progressively clarified the fundamental anatomical structures, thereby refining surgical techniques in accordance with fascial and mesenteric anatomical principles. This study synthesizes the author's anatomical research findings to dissect the fascial and mesenteric anatomy of the ligaments pertinent to colon cancer surgery, thereby exploring their implications for surgical practice and oncological outcomes. The gastrocolic ligament exhibits distinct fascial and mesenteric anatomical configurations within the omental sac and extra-omental regions. Within the omental sac, the sub-omental arch pathway emerges as a viable alternative to the paracolic approach for accessing the omental sac through the gastrocolic ligament. Conversely, in the extra-omental region, the incision of the greater omentum overlaying the space between the mesogastrium and the transverse mesocolon represents a mesenteric bridge facilitating access to this area. The incidence of nodal metastasis in the gastrocolic ligament associated with transverse colon and hepatic flexure colon cancer is notably low; nevertheless, selective dissection in high-risk patients can still provide survival benefits. The splenocolic ligament is formed by the convergence of the splenic hilum region of the mesogastrium (including the pancreatic mesentery) with the mesocolon of the splenic flexure of the colon. A natural avascular plane exists within it, and dissection along this plane can avoid encountering the branches of the left gastroepiploic artery that are typically encountered in traditional dissection routes. To date, there is no compelling evidence advocating for the resection of the splenic hilum region of the mesogastrium or the lymph nodes of the gastrocolic ligament in the context of splenic flexure colon cancer.

结肠癌手术治疗中不可或缺的韧带结构包括胃结肠韧带、膈结肠韧带和脾结肠韧带。历史上,传统开腹手术的特点是使用大型镊子夹持和结扎这些韧带。然而,筋膜和肠系膜解剖学研究的出现带来了模式的转变。在高清腹腔镜的帮助下,结直肠外科医生逐渐明确了基本的解剖结构,从而根据筋膜和肠系膜解剖学原理改进了手术技巧。本研究综合了作者的解剖学研究成果,剖析了结肠癌手术相关韧带的筋膜和肠系膜解剖结构,从而探讨了它们对手术实践和肿瘤治疗效果的影响。胃结肠韧带在网膜囊和网膜外区域表现出不同的筋膜和肠系膜解剖结构。在大网膜囊内,胃结肠弓下途径是通过胃结肠韧带进入大网膜囊的一种可行的替代旁结肠途径。相反,在大网膜外区域,切开覆盖在胃中隔和横结肠系膜之间的大网膜,代表了一种肠系膜桥,便于进入这一区域。与横结肠和肝曲结肠癌相关的胃结肠韧带结节转移的发生率很低;尽管如此,对高危患者进行选择性切除仍能提高生存率。脾结肠韧带由胃中叶脾门区(包括胰肠系膜)与结肠脾曲结肠系膜汇合而成。其中存在一个天然的无血管平面,沿该平面进行解剖可以避免遇到传统解剖路径中通常会遇到的胃十二指肠左动脉分支。迄今为止,还没有令人信服的证据主张在脾曲结肠癌的情况下切除胃中膜脾门区或胃结肠韧带淋巴结。
{"title":"[Fascial anatomy of ligamentous structures associated with colon cancer surgery].","authors":"X J Wang","doi":"10.3760/cma.j.cn441530-20240708-00237","DOIUrl":"10.3760/cma.j.cn441530-20240708-00237","url":null,"abstract":"<p><p>The ligamentous structures integral to the surgical management of colon cancer include the gastrocolic ligament, the phrenicocolic ligament, and the splenocolic ligament. Historically, the era of conventional open surgery was characterized by the use of large forceps for clamping and ligating these ligaments. However, the advent of fascial and mesenteric anatomy research has ushered in a paradigm shift. Aided by high-definition laparoscopy, colorectal surgeons have progressively clarified the fundamental anatomical structures, thereby refining surgical techniques in accordance with fascial and mesenteric anatomical principles. This study synthesizes the author's anatomical research findings to dissect the fascial and mesenteric anatomy of the ligaments pertinent to colon cancer surgery, thereby exploring their implications for surgical practice and oncological outcomes. The gastrocolic ligament exhibits distinct fascial and mesenteric anatomical configurations within the omental sac and extra-omental regions. Within the omental sac, the sub-omental arch pathway emerges as a viable alternative to the paracolic approach for accessing the omental sac through the gastrocolic ligament. Conversely, in the extra-omental region, the incision of the greater omentum overlaying the space between the mesogastrium and the transverse mesocolon represents a mesenteric bridge facilitating access to this area. The incidence of nodal metastasis in the gastrocolic ligament associated with transverse colon and hepatic flexure colon cancer is notably low; nevertheless, selective dissection in high-risk patients can still provide survival benefits. The splenocolic ligament is formed by the convergence of the splenic hilum region of the mesogastrium (including the pancreatic mesentery) with the mesocolon of the splenic flexure of the colon. A natural avascular plane exists within it, and dissection along this plane can avoid encountering the branches of the left gastroepiploic artery that are typically encountered in traditional dissection routes. To date, there is no compelling evidence advocating for the resection of the splenic hilum region of the mesogastrium or the lymph nodes of the gastrocolic ligament in the context of splenic flexure colon cancer.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"898-903"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Theory and practice on mesentery margin in vessel-oriented complete mesentery resection of gastric cancer]. [以血管为导向的胃癌全系膜切除术中系膜边缘的理论与实践]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240722-00254
L C Chen

The concept of mesenteric anatomy has been evolving in cognition. With the continuous development of endoscopic techniques, the submicroscopic structures of many mesenteries have been gradually understood, ultimately confirming the ubiquitous presence of mesenteries in the digestive organs. Based on various domestic and foreign mesenteric anatomical theories and combined with years of clinical practice, we have summarized and proposed a new concept and theory-vascular-guided complete mesenteric resection for gastric cancer. The theoretical basis is that, from the perspective of the embryonic development of the digestive tract, the rotation of the digestive tract and its associated mesentery is always centered on blood vessels. Therefore, the supply vessels and digestive tracts and their associated mesentery are naturally connected. The mesentery is a complex structure that encompasses blood vessels, nerves, and lymphatic tissues. The blood vessels serve as the boundary of the mesentery, ensuring that the lymphatic network that drains the tumor is maximally resected. This article focuses on the complete mesenteric resection margins in gastric cancer surgery, that is, the lateral boundary of the mesentery as the vascular-supplied guided resection boundary and its mesentery, and the base boundary as the mesenteric bed. Using precise vascular guidance to define the extent of mesenteric resection will help accurately define the mesenteric margin during radical resection for different stages of gastric cancer.

肠系膜解剖学的概念一直在认知上不断发展。随着内镜技术的不断发展,人们逐渐了解了许多肠系膜的镜下结构,最终证实了肠系膜在消化器官中无处不在。根据国内外各种肠系膜解剖理论,结合多年的临床实践,我们总结并提出了一种新的理念和理论--血管引导下的胃癌肠系膜全切术。其理论依据是,从消化道胚胎发育的角度来看,消化道及其相关系膜的旋转始终以血管为中心。因此,供血血管和消化道及其相关肠系膜是天然相连的。肠系膜结构复杂,包括血管、神经和淋巴组织。血管是肠系膜的边界,可确保最大限度地切除肿瘤的淋巴管网。本文重点讨论胃癌手术中的完整肠系膜切除边缘,即以肠系膜外侧边界为血管供应引导的切除边界及其肠系膜,以肠系膜床为基底边界。使用精确的血管引导来确定肠系膜切除范围,将有助于在对不同分期的胃癌进行根治性切除时准确界定肠系膜边缘。
{"title":"[Theory and practice on mesentery margin in vessel-oriented complete mesentery resection of gastric cancer].","authors":"L C Chen","doi":"10.3760/cma.j.cn441530-20240722-00254","DOIUrl":"10.3760/cma.j.cn441530-20240722-00254","url":null,"abstract":"<p><p>The concept of mesenteric anatomy has been evolving in cognition. With the continuous development of endoscopic techniques, the submicroscopic structures of many mesenteries have been gradually understood, ultimately confirming the ubiquitous presence of mesenteries in the digestive organs. Based on various domestic and foreign mesenteric anatomical theories and combined with years of clinical practice, we have summarized and proposed a new concept and theory-vascular-guided complete mesenteric resection for gastric cancer. The theoretical basis is that, from the perspective of the embryonic development of the digestive tract, the rotation of the digestive tract and its associated mesentery is always centered on blood vessels. Therefore, the supply vessels and digestive tracts and their associated mesentery are naturally connected. The mesentery is a complex structure that encompasses blood vessels, nerves, and lymphatic tissues. The blood vessels serve as the boundary of the mesentery, ensuring that the lymphatic network that drains the tumor is maximally resected. This article focuses on the complete mesenteric resection margins in gastric cancer surgery, that is, the lateral boundary of the mesentery as the vascular-supplied guided resection boundary and its mesentery, and the base boundary as the mesenteric bed. Using precise vascular guidance to define the extent of mesenteric resection will help accurately define the mesenteric margin during radical resection for different stages of gastric cancer.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"974-977"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Thinking about the extent and technique of lower mediastinal lymph nodes dissection for adenocarcinoma of esophagogastric junction]. [食管胃交界处腺癌下纵隔淋巴结清扫范围和技术思考]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20240710-00240
Y W Cao, X L Chen, K Yang

The incidence of esophagogastric junction adenocarcinoma is increasing gradually. The surgical procedures mainly include radical resection of the primary tumor, lymph node dissection, and digestive tract reconstruction. Due to the special anatomical location of esophagogastric junction adenocarcinoma, the pattern of lymph node metastasis is not clear, and regional lymph nodes dissection especially in the lower mediastinum is still controversial, and awaits further high-quality evidence. Meanwhile, due to the special anatomical location of the lower mediastinum, it is often difficult to perform lower mediastinal lymph node dissection. How to complete the lower mediastinal lymph nodes dissection more safely and effectively is the key point for gastric cancer surgeons. In this paper, the progress, consensus, and controversy on the extent of lower mediastinal lymph nodes dissection in patients with esophagogastric junction adenocarcinoma were discussed. Based on our own experience, the current clinically techniques for lower mediastinal lymph nodes dissection were summarized to further improve the quality control of lower mediastinal lymph nodes dissection in patients with esophagogastric junction adenocarcinoma.

食管胃交界处腺癌的发病率逐渐上升。手术方法主要包括原发肿瘤根治性切除、淋巴结清扫和消化道重建。由于食管胃交界处腺癌解剖位置特殊,淋巴结转移模式尚不明确,区域淋巴结清扫尤其是下纵隔淋巴结清扫仍存在争议,有待进一步的高质量证据。同时,由于下纵隔解剖位置的特殊性,下纵隔淋巴结清扫往往比较困难。如何更安全、有效地完成下纵隔淋巴结清扫是胃癌外科医生面临的关键问题。本文讨论了食管胃交界处腺癌患者下纵隔淋巴结清扫范围的进展、共识和争议。根据我们自己的经验,总结了目前临床上进行下纵隔淋巴结清扫的技术,以进一步提高食管胃交界处腺癌患者下纵隔淋巴结清扫的质量控制。
{"title":"[Thinking about the extent and technique of lower mediastinal lymph nodes dissection for adenocarcinoma of esophagogastric junction].","authors":"Y W Cao, X L Chen, K Yang","doi":"10.3760/cma.j.cn441530-20240710-00240","DOIUrl":"10.3760/cma.j.cn441530-20240710-00240","url":null,"abstract":"<p><p>The incidence of esophagogastric junction adenocarcinoma is increasing gradually. The surgical procedures mainly include radical resection of the primary tumor, lymph node dissection, and digestive tract reconstruction. Due to the special anatomical location of esophagogastric junction adenocarcinoma, the pattern of lymph node metastasis is not clear, and regional lymph nodes dissection especially in the lower mediastinum is still controversial, and awaits further high-quality evidence. Meanwhile, due to the special anatomical location of the lower mediastinum, it is often difficult to perform lower mediastinal lymph node dissection. How to complete the lower mediastinal lymph nodes dissection more safely and effectively is the key point for gastric cancer surgeons. In this paper, the progress, consensus, and controversy on the extent of lower mediastinal lymph nodes dissection in patients with esophagogastric junction adenocarcinoma were discussed. Based on our own experience, the current clinically techniques for lower mediastinal lymph nodes dissection were summarized to further improve the quality control of lower mediastinal lymph nodes dissection in patients with esophagogastric junction adenocarcinoma.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"909-913"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Peripheral blood cell count composite score as a prognostic factor in patients with colorectal cancer]. [作为结直肠癌患者预后因素的外周血细胞计数综合评分]。
Q3 Medicine Pub Date : 2024-09-25 DOI: 10.3760/cma.j.cn441530-20231029-00151
P Y Guo, X H Hu, B K Li, T Lu, J M Liu, C Y Wang, W B Niu, G Y Wang, B Yu
<p><p><b>Objective:</b> To develop a prognostic prediction model for patients with colorectal cancer based on a peripheral blood cell composite score (PBCS) system. <b>Methods:</b> This retrospective observational study included patients who had primary colorectal cancer without distant metastasis, who did not undergo radiotherapy or chemotherapy before surgery, who did not receive leukocyte or platelet-raising therapy within 1 month before surgery, and whose postoperative pathology confirmed colorectal adenocarcinoma with complete tumor resection. Patients with severe anemia, infection, or hematologic diseases before surgery, as well as those with severe heart, lung, or other important organ diseases or concurrent malignant tumors, were excluded. In total, 1021 patients with colorectal cancer who underwent surgical treatment in the Department of Gastrointestinal Surgery of the Fourth Hospital of Hebei Medical University from April 2018 to April 2020 were retrospectively included as the training set (766 patients) and the internal validation set (255 patients). Additionally, using the same criteria, 215 patients with colorectal cancer who underwent surgical treatment in another treatment group from March 2015 to December 2020 were selected as the external validation set. The "surv_cutpoint" function in R software was used to analyze the optimal cut-off values of neutrophils, lymphocytes, and platelets, and a PBCS system was established based on the optimal cut-off values. The scoring rules of the PBCS system were as follows: Neutrophils and platelets below the optimal cut-off value = 1 point, otherwise 0 points; Lymphocytes above the optimal cut-off value = 1 point, otherwise 0 points. The scores of the three cell types were added together to obtain the PBCS. Univariate and multivariate Cox regression analyses were performed to explore the correlation between patients' clinicopathological features and prognosis, and a nomogram was constructed based on the Cox regression analysis to predict patients' prognosis. The accuracy of the nomogram prediction model was validated using the C-index, calibration curve, and decision curve analysis. <b>Results:</b> The optimal cut-off values for neutrophils, lymphocytes, and platelets were 4.40×10<sup>9</sup>/L, 1.41×10<sup>9</sup>/L, and 355×10<sup>9</sup>/L, respectively. The patients were divided into high and low groups according to the optimal cut-off values of these cells. Survival curve analysis showed that a high lymphocyte count (training set: <i>P</i>=0.042, internal validation: <i>P</i>=0.010, external validation: <i>P</i>=0.029), low neutrophil count (training set: <i>P</i>=0.035, internal validation: <i>P</i>=0.001, external validation: <i>P</i>=0.024), and low platelet count (training set: <i>P</i>=0.041, internal validation: <i>P</i>=0.030, external validation: <i>P</i>=0.024) were associated with prolonged overall survival (OS), with statistically significant differences in all cases. Survival a
目的基于外周血细胞综合评分(PBCS)系统,建立结直肠癌患者预后预测模型。研究方法这项回顾性观察研究纳入的患者均为无远处转移的原发性结直肠癌患者,术前未接受放疗或化疗,术前 1 个月内未接受白细胞或血小板升高治疗,术后病理证实为肿瘤完全切除的结直肠腺癌。手术前患有严重贫血、感染或血液病的患者,以及患有严重心脏、肺部或其他重要器官疾病或同时患有恶性肿瘤的患者均被排除在外。回顾性纳入2018年4月至2020年4月在河北医科大学第四医院胃肠外科接受手术治疗的结直肠癌患者共1021例,作为训练集(766例)和内部验证集(255例)。此外,采用相同的标准,选取2015年3月至2020年12月在其他治疗组接受手术治疗的215例结直肠癌患者作为外部验证集。利用 R 软件中的 "surv_cutpoint "函数分析了中性粒细胞、淋巴细胞和血小板的最佳临界值,并根据最佳临界值建立了 PBCS 系统。PBCS 系统的评分规则如下:中性粒细胞和血小板低于最佳临界值=1 分,否则为 0 分;淋巴细胞高于最佳临界值=1 分,否则为 0 分。三种细胞类型的得分相加得出 PBCS。为探讨患者临床病理特征与预后之间的相关性,进行了单变量和多变量 Cox 回归分析,并根据 Cox 回归分析构建了预测患者预后的提名图。利用 C 指数、校准曲线和决策曲线分析验证了提名图预测模型的准确性。结果显示中性粒细胞、淋巴细胞和血小板的最佳临界值分别为 4.40×109/L、1.41×109/L 和 355×109/L。根据这些细胞的最佳临界值将患者分为高、低两组。生存曲线分析表明,淋巴细胞计数越高(训练集:P=0.042,内部测试:P=0.042P=0.042,内部验证:P=0.010,外部验证:P=0.010:P=0.010,外部验证:中性粒细胞计数低(训练集:P=0.035,内部验证:P=0.001,外部验证:P=0.029):P=0.001,外部验证:P=0.024P=0.024)和血小板计数低(训练集:P=0.041,内部验证:P=0.001,外部验证:P=0.024):训练集:P=0.041,内部验证:P=0.030,外部验证:P=0.024:P=0.030,外部验证:P=0.024)相关:P=0.024)与总生存期(OS)延长相关,所有病例的差异均有统计学意义。对不同 PBCS 组的生存分析表明,PBCS 高的患者比 PBCS 低的患者有更长的 OS(PPPP>0.05)。将上述独立风险或保护因素纳入 R 软件,构建了预测 OS 的提名图。C指数(0.873)、校准曲线和决策曲线分析(阈值概率:0.0%-75.2%)均表明,提名图预测模型对OS具有良好的预测性能。结论本研究表明,根据术前外周血中性粒细胞、淋巴细胞和血小板水平构建的 PBCS 是与结直肠癌患者预后相关的独立因素。基于该评分系统构建的提名图模型对这些患者的预后具有良好的预测效果。
{"title":"[Peripheral blood cell count composite score as a prognostic factor in patients with colorectal cancer].","authors":"P Y Guo, X H Hu, B K Li, T Lu, J M Liu, C Y Wang, W B Niu, G Y Wang, B Yu","doi":"10.3760/cma.j.cn441530-20231029-00151","DOIUrl":"10.3760/cma.j.cn441530-20231029-00151","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To develop a prognostic prediction model for patients with colorectal cancer based on a peripheral blood cell composite score (PBCS) system. &lt;b&gt;Methods:&lt;/b&gt; This retrospective observational study included patients who had primary colorectal cancer without distant metastasis, who did not undergo radiotherapy or chemotherapy before surgery, who did not receive leukocyte or platelet-raising therapy within 1 month before surgery, and whose postoperative pathology confirmed colorectal adenocarcinoma with complete tumor resection. Patients with severe anemia, infection, or hematologic diseases before surgery, as well as those with severe heart, lung, or other important organ diseases or concurrent malignant tumors, were excluded. In total, 1021 patients with colorectal cancer who underwent surgical treatment in the Department of Gastrointestinal Surgery of the Fourth Hospital of Hebei Medical University from April 2018 to April 2020 were retrospectively included as the training set (766 patients) and the internal validation set (255 patients). Additionally, using the same criteria, 215 patients with colorectal cancer who underwent surgical treatment in another treatment group from March 2015 to December 2020 were selected as the external validation set. The \"surv_cutpoint\" function in R software was used to analyze the optimal cut-off values of neutrophils, lymphocytes, and platelets, and a PBCS system was established based on the optimal cut-off values. The scoring rules of the PBCS system were as follows: Neutrophils and platelets below the optimal cut-off value = 1 point, otherwise 0 points; Lymphocytes above the optimal cut-off value = 1 point, otherwise 0 points. The scores of the three cell types were added together to obtain the PBCS. Univariate and multivariate Cox regression analyses were performed to explore the correlation between patients' clinicopathological features and prognosis, and a nomogram was constructed based on the Cox regression analysis to predict patients' prognosis. The accuracy of the nomogram prediction model was validated using the C-index, calibration curve, and decision curve analysis. &lt;b&gt;Results:&lt;/b&gt; The optimal cut-off values for neutrophils, lymphocytes, and platelets were 4.40×10&lt;sup&gt;9&lt;/sup&gt;/L, 1.41×10&lt;sup&gt;9&lt;/sup&gt;/L, and 355×10&lt;sup&gt;9&lt;/sup&gt;/L, respectively. The patients were divided into high and low groups according to the optimal cut-off values of these cells. Survival curve analysis showed that a high lymphocyte count (training set: &lt;i&gt;P&lt;/i&gt;=0.042, internal validation: &lt;i&gt;P&lt;/i&gt;=0.010, external validation: &lt;i&gt;P&lt;/i&gt;=0.029), low neutrophil count (training set: &lt;i&gt;P&lt;/i&gt;=0.035, internal validation: &lt;i&gt;P&lt;/i&gt;=0.001, external validation: &lt;i&gt;P&lt;/i&gt;=0.024), and low platelet count (training set: &lt;i&gt;P&lt;/i&gt;=0.041, internal validation: &lt;i&gt;P&lt;/i&gt;=0.030, external validation: &lt;i&gt;P&lt;/i&gt;=0.024) were associated with prolonged overall survival (OS), with statistically significant differences in all cases. Survival a","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"27 9","pages":"953-965"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
中华胃肠外科杂志
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1