Pub Date : 2025-12-25DOI: 10.3760/cma.j.cn441530-20251027-00403
Anorectal abscess is a common anorectal disease. In daily clinical practice, there are certain controversies regarding the clinical examination and diagnosis of anorectal abscesses, the selection of surgical methods for different types of abscesses, postoperative management, and treatment strategies for special types of anorectal abscesses.In recent years, there have been new advances in the clinical diagnosis and treatment of anorectal abscess. To promote the development of the specialty and standardize and improve the diagnosis and treatment level of specialist doctors, the Colorectal Physician Branch of the Chinese Medical Doctor Association organized experts in this field. Based on summarizing new research progress in this field at home and abroad, and after repeated discussions by expert group members, nine important clinical questions were summarized. Nineteen recommendations were formed targeting clinical diagnosis and examination strategies, surgical method selection, postoperative management, and treatment strategies for special types of anorectal abscesses, aiming to provide important guidance for specialist physicians, medical personnel, and patients who wish to understand the treatment of related diseases included in the guidelines.
{"title":"[Expert consensus on clinical diagnosis and treatment of anorectal abscess (2025 version)].","authors":"","doi":"10.3760/cma.j.cn441530-20251027-00403","DOIUrl":"10.3760/cma.j.cn441530-20251027-00403","url":null,"abstract":"<p><p>Anorectal abscess is a common anorectal disease. In daily clinical practice, there are certain controversies regarding the clinical examination and diagnosis of anorectal abscesses, the selection of surgical methods for different types of abscesses, postoperative management, and treatment strategies for special types of anorectal abscesses.In recent years, there have been new advances in the clinical diagnosis and treatment of anorectal abscess. To promote the development of the specialty and standardize and improve the diagnosis and treatment level of specialist doctors, the Colorectal Physician Branch of the Chinese Medical Doctor Association organized experts in this field. Based on summarizing new research progress in this field at home and abroad, and after repeated discussions by expert group members, nine important clinical questions were summarized. Nineteen recommendations were formed targeting clinical diagnosis and examination strategies, surgical method selection, postoperative management, and treatment strategies for special types of anorectal abscesses, aiming to provide important guidance for specialist physicians, medical personnel, and patients who wish to understand the treatment of related diseases included in the guidelines.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1369-1378"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-25DOI: 10.3760/cma.j.cn441530-20250810-00300
Z B Mei, Y L Cao, B B Lv, S Y Wang, K Tian, Q L Liu, L Z Ma, Y S Wang, D Wei
<p><p><b>Objective:</b> To compare the clinical efficacy of laparoscopic pelvic floor autologous fascia integral repair based on membrane anatomy versus transperineal proctosigmoidectomy (Altemeier procedure) in the treatment of patients with complete rectal prolapse (CRP). <b>Methods:</b> This study employed a retrospective observational cohort design. Clinical data were collected from a total of 55 CRP patients who underwent surgical treatment between January 2018 and July 2023, including 25 patients from Luoyang Central Hospital, affiliated with Zhengzhou University, and 30 patients from the 989th Hospital of the Joint Logistics Support Force & Military Anorectal Surgery Research Institute. All patients undergoing surgery met the following criteria: aged ≥ 18 years, rectal prolapse protruding outside the anus, prolapse length > 5 cm with inability to self-reduce, conforming to the diagnostic criteria for CRP, and being first-time treated patients. Twenty-seven patients who underwent the Altemeier procedure between January 2018 and March 2021 were assigned to the Altemeier group; 28 patients who underwent laparoscopic pelvic floor autologous fascia integral repair based on membrane anatomy between April 2021 and July 2023 were assigned to the integral repair group. The therapeutic efficacy differences between the two groups were analyzed and compared, including the CRP length (DCRP), Wexner Constipation Score, Wexner Fecal Incontinence Score, and Gastrointestinal Quality of Life Index (GIQLI) before surgery and at 6, 12, and 24 months after surgery, as well as postoperative complications and recurrence at 24 months after surgery. <b>Results:</b> There were no statistically significant differences between the two groups in terms of gender distribution, age, preoperative body mass index (BMI), defecation frequency, DCRP, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI (all <i>P</i>>0.05). All patients completed the surgery. The length of hospital stay and intraoperative blood loss in the integral repair group were significantly less than those in the Altemeier group (both <i>P</i><0.01). At 6, 12, and 24 months after surgery, the DCRP, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI in both groups significantly improved compared with the preoperative values (all <i>P</i><0.001). At 6, 12, and 24 months after surgery, the CRP treatment effect, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI in the integral repair group were significantly better than those in the Altemeier group (χ²=15.821, <i>P</i><0.001; χ²=18.238, <i>P</i><0.001; χ² = 12.558, <i>P</i>=0.001; and χ² =22.413, <i>P</i><0.001, respectively). In the integral repair group, 4 patients (14.3%) developed grade I-III postoperative complications, including 2 cases of urinary retention, 1 case of anastomotic bleeding, and 1 case of anastomotic stenosis. In the Altemeier group, 11 patients (40.7%) developed grade I-III postope
{"title":"[Efficacy observation of pelvic floor autologous fascia integrated repair based on membrane anatomy for complete rectal prolapse].","authors":"Z B Mei, Y L Cao, B B Lv, S Y Wang, K Tian, Q L Liu, L Z Ma, Y S Wang, D Wei","doi":"10.3760/cma.j.cn441530-20250810-00300","DOIUrl":"10.3760/cma.j.cn441530-20250810-00300","url":null,"abstract":"<p><p><b>Objective:</b> To compare the clinical efficacy of laparoscopic pelvic floor autologous fascia integral repair based on membrane anatomy versus transperineal proctosigmoidectomy (Altemeier procedure) in the treatment of patients with complete rectal prolapse (CRP). <b>Methods:</b> This study employed a retrospective observational cohort design. Clinical data were collected from a total of 55 CRP patients who underwent surgical treatment between January 2018 and July 2023, including 25 patients from Luoyang Central Hospital, affiliated with Zhengzhou University, and 30 patients from the 989th Hospital of the Joint Logistics Support Force & Military Anorectal Surgery Research Institute. All patients undergoing surgery met the following criteria: aged ≥ 18 years, rectal prolapse protruding outside the anus, prolapse length > 5 cm with inability to self-reduce, conforming to the diagnostic criteria for CRP, and being first-time treated patients. Twenty-seven patients who underwent the Altemeier procedure between January 2018 and March 2021 were assigned to the Altemeier group; 28 patients who underwent laparoscopic pelvic floor autologous fascia integral repair based on membrane anatomy between April 2021 and July 2023 were assigned to the integral repair group. The therapeutic efficacy differences between the two groups were analyzed and compared, including the CRP length (DCRP), Wexner Constipation Score, Wexner Fecal Incontinence Score, and Gastrointestinal Quality of Life Index (GIQLI) before surgery and at 6, 12, and 24 months after surgery, as well as postoperative complications and recurrence at 24 months after surgery. <b>Results:</b> There were no statistically significant differences between the two groups in terms of gender distribution, age, preoperative body mass index (BMI), defecation frequency, DCRP, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI (all <i>P</i>>0.05). All patients completed the surgery. The length of hospital stay and intraoperative blood loss in the integral repair group were significantly less than those in the Altemeier group (both <i>P</i><0.01). At 6, 12, and 24 months after surgery, the DCRP, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI in both groups significantly improved compared with the preoperative values (all <i>P</i><0.001). At 6, 12, and 24 months after surgery, the CRP treatment effect, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI in the integral repair group were significantly better than those in the Altemeier group (χ²=15.821, <i>P</i><0.001; χ²=18.238, <i>P</i><0.001; χ² = 12.558, <i>P</i>=0.001; and χ² =22.413, <i>P</i><0.001, respectively). In the integral repair group, 4 patients (14.3%) developed grade I-III postoperative complications, including 2 cases of urinary retention, 1 case of anastomotic bleeding, and 1 case of anastomotic stenosis. In the Altemeier group, 11 patients (40.7%) developed grade I-III postope","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1441-1447"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-25DOI: 10.3760/cma.j.cn441530-20251017-00385
X Y Wan, D L Ren
Anorectal surgery is transitioning from a tradition of experience-based practice toward modern precision medicine. This evolution is driven by greater societal focus on benign diseases, changing disease patterns due to lifestyle shifts and an aging population, and rising patient expectations for painless procedures and rapid recovery, all of which present more complex clinical challenges and higher demands for humanistic care. In this context, the management of benign anorectal diseases continues to advance, supported by theoretical breakthroughs, technological innovations, and shifts in clinical philosophy. From the cushion theory of hemorrhoids and the refined understanding of anal fistula anatomy, to the use of energy devices and high-resolution imaging guidance, treatment goals have shifted from anatomical repair to functional restoration and quality-of-life improvement. This progression demonstrates both the preservation of traditional wisdom and the pursuit of rational surgical innovation. This article systematically reviews the evolution of concepts, techniques, and approaches in benign anorectal disease management, and discusses the value of multidisciplinary collaboration and individualized clinical decision-making.
{"title":"[Theoretical evolution and practical innovation in the treatment of benign anorectal diseases].","authors":"X Y Wan, D L Ren","doi":"10.3760/cma.j.cn441530-20251017-00385","DOIUrl":"10.3760/cma.j.cn441530-20251017-00385","url":null,"abstract":"<p><p>Anorectal surgery is transitioning from a tradition of experience-based practice toward modern precision medicine. This evolution is driven by greater societal focus on benign diseases, changing disease patterns due to lifestyle shifts and an aging population, and rising patient expectations for painless procedures and rapid recovery, all of which present more complex clinical challenges and higher demands for humanistic care. In this context, the management of benign anorectal diseases continues to advance, supported by theoretical breakthroughs, technological innovations, and shifts in clinical philosophy. From the cushion theory of hemorrhoids and the refined understanding of anal fistula anatomy, to the use of energy devices and high-resolution imaging guidance, treatment goals have shifted from anatomical repair to functional restoration and quality-of-life improvement. This progression demonstrates both the preservation of traditional wisdom and the pursuit of rational surgical innovation. This article systematically reviews the evolution of concepts, techniques, and approaches in benign anorectal disease management, and discusses the value of multidisciplinary collaboration and individualized clinical decision-making.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1390-1395"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-25DOI: 10.3760/cma.j.cn441530-20250805-00292
Z C Li, L Jin, Z Y Wang, J L Qin, J Wu
Objective: To investigate the clinical efficacy and safety of laser ablation and closure for the treatment of sacrococcygeal pilonidal disease (SPD) and to analyze risk factors for postoperative recurrence in male patients. Methods: A retrospective observational study was conducted to collect clinical data of 369 patients with SPD who underwent laser ablation and closure in the Anorectal Department of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine between March 2019 and December 2024. Perioperative outcomes and postoperative recurrence were analyzed. The cohort included 313 males and 56 females, with 43 patients aged ≤18 years. The median body mass index was 26.3 (IQR: 22.9, 29.6) kg/m², and the median disease duration was 28 months (IQR: 4, 76). Among them, 218 male SPD patients who underwent surgery received preoperative sex hormone testing. A logistic regression model was used to analyze the risk factors for recurrence. Results: All patients completed the surgery. The median intraoperative ablation energy delivered was 426.8 (IQR: 243.9, 683.9) J, with no occurrence of major intraoperative complications. Postoperatively, a total of 31 patients (8.4%) required analgesic medication. Within the first postoperative week, 12 patients experienced wound oozing/bleeding; hemostasis was achieved by compression alone in 5 cases, while the remaining 7 instances required suture hemostasis after failed compression attempts. No other complications were observed. The median postoperative hospital stay was 6 (IQR: 4, 8) days, and the median time to return to regular work and life was 7 (IQR: 5, 12) days. The wound healing rate was 100%, with a median wound healing time of 35 (IQR: 30, 42) days. Postoperative recurrence occurred in 19 patients (5.1%), all of whom were male. Multivariate logistic regression analysis identified age ≤18 years (OR = 4.764, 95%CI: 2.424-34.905, P = 0.008) and a history of previous SPD surgery (OR = 5.078, 95%CI: 1.431-18.019, P = 0.012) as independent risk factors for recurrence after SPD laser ablation and closure surgery. Conclusion: Laser ablation and closure are safe, effective, and minimally invasive treatments for SPD. However, particular attention should be paid to the risk of recurrence in young male patients and those with a history of previous SPD surgery.
{"title":"[Clinical efficacy of laser ablation and closure in the treatment of sacrococcygeal pilonidal disease and analysis of risk factors for postoperative recurrence in male patients].","authors":"Z C Li, L Jin, Z Y Wang, J L Qin, J Wu","doi":"10.3760/cma.j.cn441530-20250805-00292","DOIUrl":"10.3760/cma.j.cn441530-20250805-00292","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical efficacy and safety of laser ablation and closure for the treatment of sacrococcygeal pilonidal disease (SPD) and to analyze risk factors for postoperative recurrence in male patients. <b>Methods:</b> A retrospective observational study was conducted to collect clinical data of 369 patients with SPD who underwent laser ablation and closure in the Anorectal Department of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine between March 2019 and December 2024. Perioperative outcomes and postoperative recurrence were analyzed. The cohort included 313 males and 56 females, with 43 patients aged ≤18 years. The median body mass index was 26.3 (IQR: 22.9, 29.6) kg/m², and the median disease duration was 28 months (IQR: 4, 76). Among them, 218 male SPD patients who underwent surgery received preoperative sex hormone testing. A logistic regression model was used to analyze the risk factors for recurrence. <b>Results:</b> All patients completed the surgery. The median intraoperative ablation energy delivered was 426.8 (IQR: 243.9, 683.9) J, with no occurrence of major intraoperative complications. Postoperatively, a total of 31 patients (8.4%) required analgesic medication. Within the first postoperative week, 12 patients experienced wound oozing/bleeding; hemostasis was achieved by compression alone in 5 cases, while the remaining 7 instances required suture hemostasis after failed compression attempts. No other complications were observed. The median postoperative hospital stay was 6 (IQR: 4, 8) days, and the median time to return to regular work and life was 7 (IQR: 5, 12) days. The wound healing rate was 100%, with a median wound healing time of 35 (IQR: 30, 42) days. Postoperative recurrence occurred in 19 patients (5.1%), all of whom were male. Multivariate logistic regression analysis identified age ≤18 years (OR = 4.764, 95%CI: 2.424-34.905, <i>P</i> = 0.008) and a history of previous SPD surgery (OR = 5.078, 95%CI: 1.431-18.019, <i>P</i> = 0.012) as independent risk factors for recurrence after SPD laser ablation and closure surgery. <b>Conclusion:</b> Laser ablation and closure are safe, effective, and minimally invasive treatments for SPD. However, particular attention should be paid to the risk of recurrence in young male patients and those with a history of previous SPD surgery.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1448-1454"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-25DOI: 10.3760/cma.j.cn441530-20250416-00162
In recent years, the proportion of early gastric cancer and proximal gastric cancer has risen, and function-preserving gastrectomy has received increasing attention. Proximal gastrectomy has also been highly valued. Reflux esophagitis is an issue that cannot be ignored in the reconstruction of the digestive tract after proximal gastrectomy. For this reason, a series of anti-reflux surgical methods have emerged and been applied in clinical practice. Jejunal interstitial reconstruction is one of the widely used anti-reflux surgical methods in clinical practice at present, but there is a lack of standardized guidance in terms of application indications and operation procedures. This consensus was formulated based on the latest evidence-based medical evidence and after multiple expert discussions, aiming to provide reference and guidance for clinicians in choosing proximal gastrectomy and jejunal interstitial reconstruction.
{"title":"[Experts consensus on proximal gastrectomy with jejunal interposition reconstruction (2025 version)].","authors":"","doi":"10.3760/cma.j.cn441530-20250416-00162","DOIUrl":"10.3760/cma.j.cn441530-20250416-00162","url":null,"abstract":"<p><p>In recent years, the proportion of early gastric cancer and proximal gastric cancer has risen, and function-preserving gastrectomy has received increasing attention. Proximal gastrectomy has also been highly valued. Reflux esophagitis is an issue that cannot be ignored in the reconstruction of the digestive tract after proximal gastrectomy. For this reason, a series of anti-reflux surgical methods have emerged and been applied in clinical practice. Jejunal interstitial reconstruction is one of the widely used anti-reflux surgical methods in clinical practice at present, but there is a lack of standardized guidance in terms of application indications and operation procedures. This consensus was formulated based on the latest evidence-based medical evidence and after multiple expert discussions, aiming to provide reference and guidance for clinicians in choosing proximal gastrectomy and jejunal interstitial reconstruction.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1379-1389"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-25DOI: 10.3760/cma.j.cn441530-20250830-00322
Y Luo, T T Hou, Y F Mu, C D Miao, T Y Gong, J Qin, D Y Wang, D W Song, H Li, S L Qin, R Cui, T F Wang, M Zhong, M H Yu
<p><p><b>Objective:</b> To compare postoperative anal function recovery between laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis and laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation. <b>Methods:</b> This multicenter retrospective cohort study enrolled patients meeting the following criteria: (1) severe constipation symptoms (<2 bowel movements/week), absent or insignificant defecation urge, abdominal distension, requiring laxatives to maintain bowel movements or laxatives being ineffective; (2) constipation symptoms for over 5 years, ineffective after >2 years of medical treatment, with strong desire for surgery; (3) significantly prolonged colon transit time (>72 hours) without significant gastric or small intestinal transit dysfunction; (4) no organic colonic lesions confirmed by colonoscopy and abdominal CT. Exclusion criteria: (1) patients undergoing open surgery; (2) exclusion of outlet obstruction constipation (e.g., rectocele, rectal prolapse, puborectalis spasm) by functional defecation MRI; (3) comorbid psychiatric disorders; (4) missing clinical data or loss to follow-up (postoperative follow-up <24 months). Based on these criteria, clinical and follow-up data were collected from 220 patients who underwent either laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSC group, <i>n</i> = 115) or laparoscopic total colectomy with ileorectal anastomosis (LTC group, <i>n</i> = 105) for slow transit constipation between January 2013 and December 2022. Subjective anal function (Constipation Severity Score and Wexner Fecal Incontinence Score) and objective anal function (positive rate of rectoanal inhibitory reflex [RAIR] and anorectal manometry) were observed preoperatively and at 6, 12, and 24 months postoperatively. <b>Results:</b> No significant differences were found in baseline characteristics between the two groups (all <i>P</i> >0.05). All surgeries were completed successfully without major significant complications. Subjective anal function assessment: At 24 months postoperatively, Constipation Severity Scores decreased significantly compared to preoperative scores in both groups [LSC group: (25.2±2.8) vs. (2.9±1.8), <i>P</i> <0.001; LTC group: (25.8±2.9) vs. (2.8±1.9), <i>P</i><0.001]. No significant differences were found between the groups at 6, 12, and 24 months postoperatively (all <i>P</i>>0.05). Wexner Fecal Incontinence Scores at 24 months were significantly lower than those at 6 months in both groups [LSC group: (12.9±1.8) vs. (3.9±2.5), <i>P</i><0.001; LTC group: (12.6±1.8) vs. (5.4±2.4), <i>P</i><0.001]. Although no significant difference was found at 6 months (<i>P</i> = 0.190), the LSC group had significantly lower Wexner scores than the LTC group at 12 and 24 months postoperatively (both <i>P</i> < 0.001). Objective anal function assessment: (1) Positive RAIR rate: Preoperative positive RAIR rates were 33.0% (38/115) in the LSC group
{"title":"[Laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis versus laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation: a multicenter retrospective cohort study].","authors":"Y Luo, T T Hou, Y F Mu, C D Miao, T Y Gong, J Qin, D Y Wang, D W Song, H Li, S L Qin, R Cui, T F Wang, M Zhong, M H Yu","doi":"10.3760/cma.j.cn441530-20250830-00322","DOIUrl":"10.3760/cma.j.cn441530-20250830-00322","url":null,"abstract":"<p><p><b>Objective:</b> To compare postoperative anal function recovery between laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis and laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation. <b>Methods:</b> This multicenter retrospective cohort study enrolled patients meeting the following criteria: (1) severe constipation symptoms (<2 bowel movements/week), absent or insignificant defecation urge, abdominal distension, requiring laxatives to maintain bowel movements or laxatives being ineffective; (2) constipation symptoms for over 5 years, ineffective after >2 years of medical treatment, with strong desire for surgery; (3) significantly prolonged colon transit time (>72 hours) without significant gastric or small intestinal transit dysfunction; (4) no organic colonic lesions confirmed by colonoscopy and abdominal CT. Exclusion criteria: (1) patients undergoing open surgery; (2) exclusion of outlet obstruction constipation (e.g., rectocele, rectal prolapse, puborectalis spasm) by functional defecation MRI; (3) comorbid psychiatric disorders; (4) missing clinical data or loss to follow-up (postoperative follow-up <24 months). Based on these criteria, clinical and follow-up data were collected from 220 patients who underwent either laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSC group, <i>n</i> = 115) or laparoscopic total colectomy with ileorectal anastomosis (LTC group, <i>n</i> = 105) for slow transit constipation between January 2013 and December 2022. Subjective anal function (Constipation Severity Score and Wexner Fecal Incontinence Score) and objective anal function (positive rate of rectoanal inhibitory reflex [RAIR] and anorectal manometry) were observed preoperatively and at 6, 12, and 24 months postoperatively. <b>Results:</b> No significant differences were found in baseline characteristics between the two groups (all <i>P</i> >0.05). All surgeries were completed successfully without major significant complications. Subjective anal function assessment: At 24 months postoperatively, Constipation Severity Scores decreased significantly compared to preoperative scores in both groups [LSC group: (25.2±2.8) vs. (2.9±1.8), <i>P</i> <0.001; LTC group: (25.8±2.9) vs. (2.8±1.9), <i>P</i><0.001]. No significant differences were found between the groups at 6, 12, and 24 months postoperatively (all <i>P</i>>0.05). Wexner Fecal Incontinence Scores at 24 months were significantly lower than those at 6 months in both groups [LSC group: (12.9±1.8) vs. (3.9±2.5), <i>P</i><0.001; LTC group: (12.6±1.8) vs. (5.4±2.4), <i>P</i><0.001]. Although no significant difference was found at 6 months (<i>P</i> = 0.190), the LSC group had significantly lower Wexner scores than the LTC group at 12 and 24 months postoperatively (both <i>P</i> < 0.001). Objective anal function assessment: (1) Positive RAIR rate: Preoperative positive RAIR rates were 33.0% (38/115) in the LSC group","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1426-1433"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.3760/cma.j.cn441530-20250406-00318
H F Pan, J H Ye, H Y Zhu, X J Wang, Y W Sun, Z F Chen, Z B Xu, S H Huang, W Z Jiang, P Chi, Y Huang
<p><p><b>Objective:</b> To evaluate the short-term and long-term outcomes of patients with locally advanced low rectal cancer who achieved clinical complete response (cCR) or near-clinical complete response (near-cCR) after neoadjuvant chemoradiotherapy (nCRT) and then underwent local excision. <b>Methods:</b> This was a descriptive case series study. Clinical data of patients with low rectal cancer who received neoadjuvant therapy, achieved cCR or near-cCR, underwent local excision, and had complete postoperative follow-up data were retrospectively analyzed. The study period was from May, 2015 to October, 2024, and the patients were treated at Fujian Medical University Union Hospital. Indications for local excision in this study were as follows: pathologically confirmed rectal adenocarcinoma, with the lower edge of the tumor ≤ 6 cm from the anal verge; maximum diameter of the lesion ≤ 2 cm after nCRT; no regional lymph node metastasis detected by transrectal endoscopic ultrasound (ERUS), pelvic magnetic resonance imaging (MRI), or positron emission tomography-computed tomography (PET-CT) after nCRT; MRI showing fibrosis of the primary lesion with a small amount of high signal on diffusion-weighted imaging (DWI), consistent with ymrT0-1 stage; serum carcinoembryonic antigen level within the normal range (< 5 μg/L) after nCRT; complicated with severe underlying diseases such as cardiovascular and cerebrovascular diseases and assessed as unable to tolerate radical surgery through comprehensive evaluation; and signed informed consent for local excision. The contraindications were: colonoscopic pathology indicating poorly differentiated adenocarcinoma or signet ring cell carcinoma; suspected lateral lymph node metastasis before neoadjuvant therapy; patients with residual lesions exceeding 3 cm in range after treatment. A total of 153 patients were included in this study, including 84 males and 69 females. The median age was 62 years, and the median distance from the tumor to the anal verge after neoadjuvant therapy was 4.0 cm. The short-term efficacy indicators of this study included postoperative complications of local excision and postoperative pathological results, and the long-term efficacy indicators included oncological prognosis (3-year cumulative local recurrence rate, 3-year cumulative distant metastasis rate, 3-year progression-free survival, and 3-year overall survival) and anal function at 1 year after surgery evaluated using the Low Anterior Resection Syndrome (LARS) scale where the total score is 42 points such that 0-20 points indicate no LARS, 21-29 points indicate mild LARS, and 30-42 points indicate severe LARS. <b>Results:</b> Postoperative pathology showed 122 cases (79.7%) of ypT0 stage, 10 cases (6.5%) of ypT1 stage, 18 cases (11.8%) of ypT2 stage, and 3 cases (2.0%) of ypT3 stage. The incidence of surgery-related complications was 42.5% (65/153), and the main complications included perianal pain (39.9%, 61/153), intestinal wall
{"title":"[Prognostic analysis of local excision in 153 cases of locally advanced low rectal cancer following neoadjuvant therapy].","authors":"H F Pan, J H Ye, H Y Zhu, X J Wang, Y W Sun, Z F Chen, Z B Xu, S H Huang, W Z Jiang, P Chi, Y Huang","doi":"10.3760/cma.j.cn441530-20250406-00318","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20250406-00318","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the short-term and long-term outcomes of patients with locally advanced low rectal cancer who achieved clinical complete response (cCR) or near-clinical complete response (near-cCR) after neoadjuvant chemoradiotherapy (nCRT) and then underwent local excision. <b>Methods:</b> This was a descriptive case series study. Clinical data of patients with low rectal cancer who received neoadjuvant therapy, achieved cCR or near-cCR, underwent local excision, and had complete postoperative follow-up data were retrospectively analyzed. The study period was from May, 2015 to October, 2024, and the patients were treated at Fujian Medical University Union Hospital. Indications for local excision in this study were as follows: pathologically confirmed rectal adenocarcinoma, with the lower edge of the tumor ≤ 6 cm from the anal verge; maximum diameter of the lesion ≤ 2 cm after nCRT; no regional lymph node metastasis detected by transrectal endoscopic ultrasound (ERUS), pelvic magnetic resonance imaging (MRI), or positron emission tomography-computed tomography (PET-CT) after nCRT; MRI showing fibrosis of the primary lesion with a small amount of high signal on diffusion-weighted imaging (DWI), consistent with ymrT0-1 stage; serum carcinoembryonic antigen level within the normal range (< 5 μg/L) after nCRT; complicated with severe underlying diseases such as cardiovascular and cerebrovascular diseases and assessed as unable to tolerate radical surgery through comprehensive evaluation; and signed informed consent for local excision. The contraindications were: colonoscopic pathology indicating poorly differentiated adenocarcinoma or signet ring cell carcinoma; suspected lateral lymph node metastasis before neoadjuvant therapy; patients with residual lesions exceeding 3 cm in range after treatment. A total of 153 patients were included in this study, including 84 males and 69 females. The median age was 62 years, and the median distance from the tumor to the anal verge after neoadjuvant therapy was 4.0 cm. The short-term efficacy indicators of this study included postoperative complications of local excision and postoperative pathological results, and the long-term efficacy indicators included oncological prognosis (3-year cumulative local recurrence rate, 3-year cumulative distant metastasis rate, 3-year progression-free survival, and 3-year overall survival) and anal function at 1 year after surgery evaluated using the Low Anterior Resection Syndrome (LARS) scale where the total score is 42 points such that 0-20 points indicate no LARS, 21-29 points indicate mild LARS, and 30-42 points indicate severe LARS. <b>Results:</b> Postoperative pathology showed 122 cases (79.7%) of ypT0 stage, 10 cases (6.5%) of ypT1 stage, 18 cases (11.8%) of ypT2 stage, and 3 cases (2.0%) of ypT3 stage. The incidence of surgery-related complications was 42.5% (65/153), and the main complications included perianal pain (39.9%, 61/153), intestinal wall","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 11","pages":"1250-1259"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.3760/cma.j.cn441530-20250102-00003
Reziya Aierken, Z W Jiang, G W Gong, P Li, X Y Liu, F Ji
Objective: To evaluate the application value of a digital technology-based multiparameter vital signs monitoring system in perioperative comprehensive full-cycle surveillance. Methods: A comprehensive multidimensional vital signs monitoring system was developed through the integration of medical-grade wireless wearable devices, incorporating patch-type ambulatory electrocardiographic monitor, continuous glucose monitoring sensor, pulse oximeter, wireless digital thermometer, smart wristband, and bioelectrical impedance analyzer. This system facilitates continuous real-time acquisition of multiple physiological parameters including electrocardiogram, blood glucose, oxygen saturation, body temperature, physical activity, and body composition indices. The acquired data were systematically integrated and analyzed through a four-level digital architecture consisting of nurse mobile interfaces, bedside patient terminals, centralized ward monitoring displays, and hospital management information systems. One patient with gastric cancer complicated by diabetes mellitus was selected for full-cycle digital monitoring from preoperative evaluation to hospital discharge. The technical performance of the monitoring system was assessed in terms of data acquisition continuity and timeliness of abnormal event alerts. Results: The monitoring system effectively identified early postoperative abnormalities, such as decreased oxygen saturation and blood glucose fluctuations, providing timely guidance for clinical intervention. The built-in algorithm enabled visualization of perioperative stress levels through heart rate variability indices and continuous glucose monitoring data. The patient demonstrated good compliance with early postoperative mobilization, and the satisfaction score for monitoring management was 4 points based on the Likert 5-point scale. Conclusions: The multiparameter vital signs monitoring system enhanced the precision of perioperative management through continuous and dynamic physiological status assessment. Its modular design aligns with the principles of enhanced recovery after surgery, offering a novel technological solution for intelligent perioperative management.
{"title":"[Perioperative digital surveillance with a multiparameter vital signs monitoring system in a gastric cancer patient with diabetes].","authors":"Reziya Aierken, Z W Jiang, G W Gong, P Li, X Y Liu, F Ji","doi":"10.3760/cma.j.cn441530-20250102-00003","DOIUrl":"10.3760/cma.j.cn441530-20250102-00003","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the application value of a digital technology-based multiparameter vital signs monitoring system in perioperative comprehensive full-cycle surveillance. <b>Methods:</b> A comprehensive multidimensional vital signs monitoring system was developed through the integration of medical-grade wireless wearable devices, incorporating patch-type ambulatory electrocardiographic monitor, continuous glucose monitoring sensor, pulse oximeter, wireless digital thermometer, smart wristband, and bioelectrical impedance analyzer. This system facilitates continuous real-time acquisition of multiple physiological parameters including electrocardiogram, blood glucose, oxygen saturation, body temperature, physical activity, and body composition indices. The acquired data were systematically integrated and analyzed through a four-level digital architecture consisting of nurse mobile interfaces, bedside patient terminals, centralized ward monitoring displays, and hospital management information systems. One patient with gastric cancer complicated by diabetes mellitus was selected for full-cycle digital monitoring from preoperative evaluation to hospital discharge. The technical performance of the monitoring system was assessed in terms of data acquisition continuity and timeliness of abnormal event alerts. <b>Results:</b> The monitoring system effectively identified early postoperative abnormalities, such as decreased oxygen saturation and blood glucose fluctuations, providing timely guidance for clinical intervention. The built-in algorithm enabled visualization of perioperative stress levels through heart rate variability indices and continuous glucose monitoring data. The patient demonstrated good compliance with early postoperative mobilization, and the satisfaction score for monitoring management was 4 points based on the Likert 5-point scale. <b>Conclusions:</b> The multiparameter vital signs monitoring system enhanced the precision of perioperative management through continuous and dynamic physiological status assessment. Its modular design aligns with the principles of enhanced recovery after surgery, offering a novel technological solution for intelligent perioperative management.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 11","pages":"1318-1322"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.3760/cma.j.cn441530-20250619-00230
W D Jiang, S H Li, S Y Li, Z Lou, W Zhang
<p><p><b>Objective:</b> To investigate the impact of circumferential tumor location (anterior wall, nonanterior wall, or circumferential) on circumferential resection margin (CRM) status, local recurrence, and survival in patients with mid-low rectal cancer. <b>Methods:</b> A retrospective cohort study was conducted using data from 696 patients with mid-low rectal adenocarcinoma who underwent surgery in the Department of Colorectal Surgery at the First Affiliated Hospital of Naval Medical University between December, 2018 and December, 2019. Based on MRI or contrast-enhanced CT findings, the rectal wall was divided into four quadrants: anterior, posterior, left, and right. Tumors were classified into three groups: anterior wall group (<i>n</i> = 245), nonanterior wall group (<i>n</i> = 286, tumors predominantly located on the posterior or lateral walls), and circumferential group (<i>n</i> = 165, tumors involving ≥ 3/4 of the circumference). Propensity score matching (PSM) was used to balance baseline characteristics. Outcomes included pathological CRM positivity, local recurrence rate (LRR), overall survival (OS), and disease-free survival (DFS). Cox regression analysis was performed to identify risk factors for recurrence, and subgroup analysis was conducted in patients who did not receive neoadjuvant therapy. <b>Results:</b> After PSM, both the anterior and circumferential groups had significantly higher pathological CRM positivity rates compared to the nonanterior wall group (<i>P</i>=0.040 and <i>P</i>=0.039, respectively). The median follow-up time was 64 months (range: 1-71 months). Compared to the nonanterior wall group, the anterior wall group also had a significantly higher 5-year LRR (8.8% vs. 2.3%, <i>P</i>=0.003), and significantly lower 5-year OS (80.7% vs. 91.6%, <i>P</i>=0.001) and DFS (76.6% vs. 84.6%, <i>P</i>=0.029). The circumferential group had a significantly higher 5-year LRR than the nonanterior wall group (11.4% vs. 3.8%, <i>P</i>=0.020), but no significant differences were observed in 5-year OS (81.8% vs. 89.5%, <i>P</i>=0.100) or DFS (70.7% vs. 78.3%, <i>P</i>=0.101). No significant differences were found between the anterior and circumferential groups in 5-year LRR (11.1% vs. 9.7%), OS (76.3% vs. 83.7%), or DFS (69.8% vs. 74.1%) either (all <i>P</i>>0.05). Cox univariate analysis and multivariate analysis identified anterior wall tumors (HR=3.751, 95%CI: 1.373-10.215, <i>P</i>=0.010), circumferential tumors (HR=3.240, 95%CI: 1.109-9.466, <i>P</i>=0.032), pathological CRM positivity (HR=3.071, 95%CI: 1.144-8.245, <i>P</i>=0.026), and lymph node metastasis (HR=2.584, 95%CI: 1.192-5.601, <i>P</i>=0.016) as independent risk factors for LRR. Conversely, a greater distance from tumor to the anal verge (per 1 cm increase, HR=0.831, 95%CI: 0.712-0.970, <i>P</i>=0.019), and neoadjuvant therapy (HR=0.442, 95%CI: 0.204-0.957, <i>P</i>=0.038) were identified as independent protective factors against LRR. In patients who did not re
目的:探讨肿瘤环周位置(前壁、非前壁、环周)对中低位直肠癌患者环周切除缘(CRM)状态、局部复发及生存的影响。方法:回顾性队列研究2018年12月至2019年12月在海军医科大学第一附属医院结直肠外科接受手术治疗的696例中低位直肠腺癌患者。根据MRI或CT增强检查结果,将直肠壁分为四个象限:前、后、左、右。肿瘤分为前壁组(245例)、非前壁组(286例,肿瘤主要位于后壁或侧壁)和周向组(165例,肿瘤累及≥3/4周长)。倾向评分匹配(PSM)用于平衡基线特征。结果包括病理性CRM阳性、局部复发率(LRR)、总生存期(OS)和无病生存期(DFS)。采用Cox回归分析确定复发危险因素,对未接受新辅助治疗的患者进行亚组分析。结果:PSM后,前壁组和环壁组的病理CRM阳性率均显著高于非前壁组(P=0.040和P=0.039)。中位随访时间64个月(范围:1-71个月)。与非前壁组相比,前壁组5年LRR (8.8% vs. 2.3%, P=0.003)显著升高,5年OS (80.7% vs. 91.6%, P=0.001)和DFS (76.6% vs. 84.6%, P=0.029)显著降低。环壁组5年LRR明显高于非前壁组(11.4%比3.8%,P=0.020),但5年OS(81.8%比89.5%,P=0.100)和DFS(70.7%比78.3%,P=0.101)差异无统计学意义。在5年LRR (11.1% vs. 9.7%)、OS (76.3% vs. 83.7%)和DFS (69.8% vs. 74.1%)方面,前路组和环路组之间均无显著差异(均P < 0.05)。Cox单因素分析和多因素分析发现,前壁肿瘤(HR=3.751, 95%CI: 1.373 ~ 10.215, P=0.010)、周周肿瘤(HR=3.240, 95%CI: 1.109 ~ 9.466, P=0.032)、病理性CRM阳性(HR=3.071, 95%CI: 1.144 ~ 8.245, P=0.026)、淋巴结转移(HR=2.584, 95%CI: 1.192 ~ 5.601, P=0.016)是LRR的独立危险因素。相反,肿瘤到肛门边缘的距离(每增加1 cm, HR=0.831, 95%CI: 0.712-0.970, P=0.019)和新辅助治疗(HR=0.442, 95%CI: 0.204-0.957, P=0.038)被认为是LRR的独立保护因素。在未接受新辅助治疗的患者中,局部晚期非前壁肿瘤的LRR明显较低(病理II-III期为1.3%,pT3-4期为1.6%)。结论:直肠肿瘤位于前壁或累及直肠周长与CRM阳性率高、局部复发率高、生存率低相关。这些患者应优先接受新辅助治疗。相比之下,非前壁肿瘤复发率低,对于这些病例可考虑选择性省略新辅助治疗。
{"title":"[Impact of tumor circumferential location on prognosis in mid-low rectal cancer: a propensity- score-matched analysis].","authors":"W D Jiang, S H Li, S Y Li, Z Lou, W Zhang","doi":"10.3760/cma.j.cn441530-20250619-00230","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20250619-00230","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the impact of circumferential tumor location (anterior wall, nonanterior wall, or circumferential) on circumferential resection margin (CRM) status, local recurrence, and survival in patients with mid-low rectal cancer. <b>Methods:</b> A retrospective cohort study was conducted using data from 696 patients with mid-low rectal adenocarcinoma who underwent surgery in the Department of Colorectal Surgery at the First Affiliated Hospital of Naval Medical University between December, 2018 and December, 2019. Based on MRI or contrast-enhanced CT findings, the rectal wall was divided into four quadrants: anterior, posterior, left, and right. Tumors were classified into three groups: anterior wall group (<i>n</i> = 245), nonanterior wall group (<i>n</i> = 286, tumors predominantly located on the posterior or lateral walls), and circumferential group (<i>n</i> = 165, tumors involving ≥ 3/4 of the circumference). Propensity score matching (PSM) was used to balance baseline characteristics. Outcomes included pathological CRM positivity, local recurrence rate (LRR), overall survival (OS), and disease-free survival (DFS). Cox regression analysis was performed to identify risk factors for recurrence, and subgroup analysis was conducted in patients who did not receive neoadjuvant therapy. <b>Results:</b> After PSM, both the anterior and circumferential groups had significantly higher pathological CRM positivity rates compared to the nonanterior wall group (<i>P</i>=0.040 and <i>P</i>=0.039, respectively). The median follow-up time was 64 months (range: 1-71 months). Compared to the nonanterior wall group, the anterior wall group also had a significantly higher 5-year LRR (8.8% vs. 2.3%, <i>P</i>=0.003), and significantly lower 5-year OS (80.7% vs. 91.6%, <i>P</i>=0.001) and DFS (76.6% vs. 84.6%, <i>P</i>=0.029). The circumferential group had a significantly higher 5-year LRR than the nonanterior wall group (11.4% vs. 3.8%, <i>P</i>=0.020), but no significant differences were observed in 5-year OS (81.8% vs. 89.5%, <i>P</i>=0.100) or DFS (70.7% vs. 78.3%, <i>P</i>=0.101). No significant differences were found between the anterior and circumferential groups in 5-year LRR (11.1% vs. 9.7%), OS (76.3% vs. 83.7%), or DFS (69.8% vs. 74.1%) either (all <i>P</i>>0.05). Cox univariate analysis and multivariate analysis identified anterior wall tumors (HR=3.751, 95%CI: 1.373-10.215, <i>P</i>=0.010), circumferential tumors (HR=3.240, 95%CI: 1.109-9.466, <i>P</i>=0.032), pathological CRM positivity (HR=3.071, 95%CI: 1.144-8.245, <i>P</i>=0.026), and lymph node metastasis (HR=2.584, 95%CI: 1.192-5.601, <i>P</i>=0.016) as independent risk factors for LRR. Conversely, a greater distance from tumor to the anal verge (per 1 cm increase, HR=0.831, 95%CI: 0.712-0.970, <i>P</i>=0.019), and neoadjuvant therapy (HR=0.442, 95%CI: 0.204-0.957, <i>P</i>=0.038) were identified as independent protective factors against LRR. In patients who did not re","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 11","pages":"1267-1279"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.3760/cma.j.cn441530-20250815-00306
J L Zhou, G L Lin
The integration of immunotherapy into neoadjuvant treatment for locally advanced rectal cancer has markedly increased complete response rates, offering greater potential for organ preservation. However, the reduced restaging accuracy after immunotherapy has limited the applicability of the watch-and-wait strategy. As an organ-preserving approach that enables residual lesion removal and pathological assessment, local excision not only reduces the risk of local regrowth associated with watch-and-wait, but also enables full-thickness tumor bed sampling to determine pathological stage, regression pattern, and molecular characteristics, thereby supporting risk stratification and individualized decision-making. Moving forward, local excision is expected to achieve precise, risk-adapted organ preservation by optimizing surgical timing and techniques, and integrating multimodal parameters including imaging, pathology, and the tumor microenvironment, ultimately attaining the dual aim of maximizing both oncologic efficacy and functional preservation.
{"title":"[Clinical value of local excision in locally advanced rectal cancer under the context of neoadjuvant immunotherapy].","authors":"J L Zhou, G L Lin","doi":"10.3760/cma.j.cn441530-20250815-00306","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20250815-00306","url":null,"abstract":"<p><p>The integration of immunotherapy into neoadjuvant treatment for locally advanced rectal cancer has markedly increased complete response rates, offering greater potential for organ preservation. However, the reduced restaging accuracy after immunotherapy has limited the applicability of the watch-and-wait strategy. As an organ-preserving approach that enables residual lesion removal and pathological assessment, local excision not only reduces the risk of local regrowth associated with watch-and-wait, but also enables full-thickness tumor bed sampling to determine pathological stage, regression pattern, and molecular characteristics, thereby supporting risk stratification and individualized decision-making. Moving forward, local excision is expected to achieve precise, risk-adapted organ preservation by optimizing surgical timing and techniques, and integrating multimodal parameters including imaging, pathology, and the tumor microenvironment, ultimately attaining the dual aim of maximizing both oncologic efficacy and functional preservation.</p>","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 11","pages":"1232-1236"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}