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中华胃肠外科杂志最新文献

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[Expert consensus on clinical diagnosis and treatment of anorectal abscess (2025 version)]. 【肛肠脓肿临床诊治专家共识(2025版)】。
Q3 Medicine Pub Date : 2025-12-25 DOI: 10.3760/cma.j.cn441530-20251027-00403

Anorectal abscess is a common anorectal disease. In daily clinical practice, there are certain controversies regarding the clinical examination and diagnosis of anorectal abscesses, the selection of surgical methods for different types of abscesses, postoperative management, and treatment strategies for special types of anorectal abscesses.In recent years, there have been new advances in the clinical diagnosis and treatment of anorectal abscess. To promote the development of the specialty and standardize and improve the diagnosis and treatment level of specialist doctors, the Colorectal Physician Branch of the Chinese Medical Doctor Association organized experts in this field. Based on summarizing new research progress in this field at home and abroad, and after repeated discussions by expert group members, nine important clinical questions were summarized. Nineteen recommendations were formed targeting clinical diagnosis and examination strategies, surgical method selection, postoperative management, and treatment strategies for special types of anorectal abscesses, aiming to provide important guidance for specialist physicians, medical personnel, and patients who wish to understand the treatment of related diseases included in the guidelines.

肛肠脓肿是一种常见的肛肠疾病。在日常临床实践中,对于肛肠脓肿的临床检查与诊断、不同类型脓肿的手术方式选择、术后处理、特殊类型肛肠脓肿的治疗策略等方面存在一定的争议。近年来,肛肠脓肿的临床诊断和治疗有了新的进展。为促进本专业的发展,规范和提高专科医生的诊疗水平,中国医师协会结直肠医师分会组织了本领域的专家。在总结国内外该领域最新研究进展的基础上,经过专家组成员的反复讨论,总结出9个重要的临床问题。针对特殊类型肛肠脓肿的临床诊断及检查策略、手术方法选择、术后管理、治疗策略等,形成了19条建议,旨在为专科医师、医务人员以及希望了解指南中相关疾病治疗的患者提供重要指导。
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引用次数: 0
[Efficacy observation of pelvic floor autologous fascia integrated repair based on membrane anatomy for complete rectal prolapse]. [基于膜解剖的盆底自体筋膜综合修复治疗完全性直肠脱垂的疗效观察]。
Q3 Medicine Pub Date : 2025-12-25 DOI: 10.3760/cma.j.cn441530-20250810-00300
Z B Mei, Y L Cao, B B Lv, S Y Wang, K Tian, Q L Liu, L Z Ma, Y S Wang, D Wei
<p><p><b>Objective:</b> To compare the clinical efficacy of laparoscopic pelvic floor autologous fascia integral repair based on membrane anatomy versus transperineal proctosigmoidectomy (Altemeier procedure) in the treatment of patients with complete rectal prolapse (CRP). <b>Methods:</b> This study employed a retrospective observational cohort design. Clinical data were collected from a total of 55 CRP patients who underwent surgical treatment between January 2018 and July 2023, including 25 patients from Luoyang Central Hospital, affiliated with Zhengzhou University, and 30 patients from the 989th Hospital of the Joint Logistics Support Force & Military Anorectal Surgery Research Institute. All patients undergoing surgery met the following criteria: aged ≥ 18 years, rectal prolapse protruding outside the anus, prolapse length > 5 cm with inability to self-reduce, conforming to the diagnostic criteria for CRP, and being first-time treated patients. Twenty-seven patients who underwent the Altemeier procedure between January 2018 and March 2021 were assigned to the Altemeier group; 28 patients who underwent laparoscopic pelvic floor autologous fascia integral repair based on membrane anatomy between April 2021 and July 2023 were assigned to the integral repair group. The therapeutic efficacy differences between the two groups were analyzed and compared, including the CRP length (DCRP), Wexner Constipation Score, Wexner Fecal Incontinence Score, and Gastrointestinal Quality of Life Index (GIQLI) before surgery and at 6, 12, and 24 months after surgery, as well as postoperative complications and recurrence at 24 months after surgery. <b>Results:</b> There were no statistically significant differences between the two groups in terms of gender distribution, age, preoperative body mass index (BMI), defecation frequency, DCRP, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI (all <i>P</i>>0.05). All patients completed the surgery. The length of hospital stay and intraoperative blood loss in the integral repair group were significantly less than those in the Altemeier group (both <i>P</i><0.01). At 6, 12, and 24 months after surgery, the DCRP, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI in both groups significantly improved compared with the preoperative values (all <i>P</i><0.001). At 6, 12, and 24 months after surgery, the CRP treatment effect, Wexner Constipation Score, Wexner Fecal Incontinence Score, and GIQLI in the integral repair group were significantly better than those in the Altemeier group (χ²=15.821, <i>P</i><0.001; χ²=18.238, <i>P</i><0.001; χ² = 12.558, <i>P</i>=0.001; and χ² =22.413, <i>P</i><0.001, respectively). In the integral repair group, 4 patients (14.3%) developed grade I-III postoperative complications, including 2 cases of urinary retention, 1 case of anastomotic bleeding, and 1 case of anastomotic stenosis. In the Altemeier group, 11 patients (40.7%) developed grade I-III postope
目的:比较基于膜解剖的腹腔镜盆底自体筋膜整体修复术与经会阴直乙状结肠切除术(Altemeier手术)治疗完全性直肠脱垂(CRP)的临床疗效。方法:采用回顾性观察队列设计。临床资料收集自2018年1月至2023年7月接受手术治疗的55例CRP患者,其中25例患者来自郑州大学附属洛阳中心医院,30例患者来自联合后勤保障部队和军队肛肠外科研究所989医院。所有接受手术的患者符合以下条件:年龄≥18岁,直肠脱垂突出于肛门外,脱垂长度bbb5cm且不能自行消退,符合CRP诊断标准,为首次治疗患者。在2018年1月至2021年3月期间接受Altemeier手术的27名患者被分配到Altemeier组;在2021年4月至2023年7月期间,28例基于膜解剖的腹腔镜盆底自体筋膜整体修复患者被分配到整体修复组。分析比较两组患者术前及术后6、12、24个月的CRP长度(DCRP)、Wexner便秘评分、Wexner大便失禁评分、胃肠道生活质量指数(GIQLI)及术后24个月的并发症及复发情况。结果:两组患者性别分布、年龄、术前体重指数(BMI)、排便次数、DCRP、Wexner便秘评分、Wexner大便失禁评分、GIQLI比较,差异均无统计学意义(P < 0.05)。所有患者均完成手术。整体修复组住院时间和术中出血量均显著小于Altemeier组(PPPPP=0.001; χ²=22.413,PP=0.028)。整体修复组术后24个月CRP无复发,而Altemeier组术后24个月CRP有7例复发。两组比较差异有统计学意义(χ 2 =6.148, P=0.013)。结论:基于膜解剖学和盆底整体理论的自体筋膜修复技术治疗CRP优于经会阴Altemeier手术。此外,它是一种有效的手术治疗CRP的方法。
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引用次数: 0
[Theoretical evolution and practical innovation in the treatment of benign anorectal diseases]. 【良性肛肠疾病治疗的理论演进与实践创新】。
Q3 Medicine Pub Date : 2025-12-25 DOI: 10.3760/cma.j.cn441530-20251017-00385
X Y Wan, D L Ren

Anorectal surgery is transitioning from a tradition of experience-based practice toward modern precision medicine. This evolution is driven by greater societal focus on benign diseases, changing disease patterns due to lifestyle shifts and an aging population, and rising patient expectations for painless procedures and rapid recovery, all of which present more complex clinical challenges and higher demands for humanistic care. In this context, the management of benign anorectal diseases continues to advance, supported by theoretical breakthroughs, technological innovations, and shifts in clinical philosophy. From the cushion theory of hemorrhoids and the refined understanding of anal fistula anatomy, to the use of energy devices and high-resolution imaging guidance, treatment goals have shifted from anatomical repair to functional restoration and quality-of-life improvement. This progression demonstrates both the preservation of traditional wisdom and the pursuit of rational surgical innovation. This article systematically reviews the evolution of concepts, techniques, and approaches in benign anorectal disease management, and discusses the value of multidisciplinary collaboration and individualized clinical decision-making.

肛肠外科正在从传统的以经验为基础的实践向现代精准医学过渡。这一演变是由以下因素推动的:社会对良性疾病的更多关注,生活方式的转变和人口老龄化导致疾病模式的改变,以及患者对无痛手术和快速康复的期望不断提高,所有这些都带来了更复杂的临床挑战和对人文关怀的更高要求。在此背景下,在理论突破、技术创新和临床理念转变的支持下,良性肛肠疾病的管理继续推进。从痔疮的缓冲理论和对肛瘘解剖的精细化认识,到能量装置和高分辨率成像指导的使用,治疗目标已经从解剖修复转向功能恢复和生活质量的提高。这一进展既体现了对传统智慧的保留,也体现了对理性外科创新的追求。本文系统回顾了良性肛肠疾病管理的概念、技术和方法的发展,并讨论了多学科合作和个性化临床决策的价值。
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引用次数: 0
[Clinical efficacy of laser ablation and closure in the treatment of sacrococcygeal pilonidal disease and analysis of risk factors for postoperative recurrence in male patients]. 【激光消融术治疗男性骶尾椎毛突病变的临床疗效及术后复发危险因素分析】。
Q3 Medicine Pub Date : 2025-12-25 DOI: 10.3760/cma.j.cn441530-20250805-00292
Z C Li, L Jin, Z Y Wang, J L Qin, J Wu

Objective: To investigate the clinical efficacy and safety of laser ablation and closure for the treatment of sacrococcygeal pilonidal disease (SPD) and to analyze risk factors for postoperative recurrence in male patients. Methods: A retrospective observational study was conducted to collect clinical data of 369 patients with SPD who underwent laser ablation and closure in the Anorectal Department of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine between March 2019 and December 2024. Perioperative outcomes and postoperative recurrence were analyzed. The cohort included 313 males and 56 females, with 43 patients aged ≤18 years. The median body mass index was 26.3 (IQR: 22.9, 29.6) kg/m², and the median disease duration was 28 months (IQR: 4, 76). Among them, 218 male SPD patients who underwent surgery received preoperative sex hormone testing. A logistic regression model was used to analyze the risk factors for recurrence. Results: All patients completed the surgery. The median intraoperative ablation energy delivered was 426.8 (IQR: 243.9, 683.9) J, with no occurrence of major intraoperative complications. Postoperatively, a total of 31 patients (8.4%) required analgesic medication. Within the first postoperative week, 12 patients experienced wound oozing/bleeding; hemostasis was achieved by compression alone in 5 cases, while the remaining 7 instances required suture hemostasis after failed compression attempts. No other complications were observed. The median postoperative hospital stay was 6 (IQR: 4, 8) days, and the median time to return to regular work and life was 7 (IQR: 5, 12) days. The wound healing rate was 100%, with a median wound healing time of 35 (IQR: 30, 42) days. Postoperative recurrence occurred in 19 patients (5.1%), all of whom were male. Multivariate logistic regression analysis identified age ≤18 years (OR = 4.764, 95%CI: 2.424-34.905, P = 0.008) and a history of previous SPD surgery (OR = 5.078, 95%CI: 1.431-18.019, P = 0.012) as independent risk factors for recurrence after SPD laser ablation and closure surgery. Conclusion: Laser ablation and closure are safe, effective, and minimally invasive treatments for SPD. However, particular attention should be paid to the risk of recurrence in young male patients and those with a history of previous SPD surgery.

目的:探讨激光消融术治疗骶尾椎毛突病(SPD)的临床疗效和安全性,并分析男性患者术后复发的危险因素。方法:采用回顾性观察研究方法,收集2019年3月至2024年12月上海中医药大学附属岳阳中西医结合医院肛肠科369例SPD激光消融闭合患者的临床资料。分析围手术期结局及术后复发率。该队列包括313名男性和56名女性,其中43名患者年龄≤18岁。中位体重指数为26.3 (IQR: 22.9, 29.6) kg/m²,中位病程为28个月(IQR: 4,76)。其中218例接受手术的男性SPD患者术前进行了性激素检测。采用logistic回归模型分析复发危险因素。结果:所有患者均完成手术。术中消融能量传递中位值为426.8 (IQR: 243.9, 683.9) J,无重大术中并发症发生。术后共有31例(8.4%)患者需要镇痛药物治疗。术后1周内,12例患者出现伤口渗血/出血;单纯按压止血5例,按压失败需缝合止血7例。无其他并发症。术后中位住院时间为6 (IQR: 4,8)天,恢复正常工作和生活的中位时间为7 (IQR: 5,12)天。创面愈合率100%,中位创面愈合时间35 (IQR: 30,42) d。术后复发19例(5.1%),均为男性。多因素logistic回归分析发现年龄≤18岁(OR = 4.764, 95%CI: 2.424 ~ 34.905, P = 0.008)和既往SPD手术史(OR = 5.078, 95%CI: 1.431 ~ 18.019, P = 0.012)是SPD激光消融及闭合手术后复发的独立危险因素。结论:激光消融和闭合是治疗SPD安全、有效、微创的方法。然而,应特别注意年轻男性患者和既往有SPD手术史的患者的复发风险。
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引用次数: 0
[Experts consensus on proximal gastrectomy with jejunal interposition reconstruction (2025 version)]. 【专家共识:近端胃切除术加空肠间置重建(2025版)】。
Q3 Medicine Pub Date : 2025-12-25 DOI: 10.3760/cma.j.cn441530-20250416-00162

In recent years, the proportion of early gastric cancer and proximal gastric cancer has risen, and function-preserving gastrectomy has received increasing attention. Proximal gastrectomy has also been highly valued. Reflux esophagitis is an issue that cannot be ignored in the reconstruction of the digestive tract after proximal gastrectomy. For this reason, a series of anti-reflux surgical methods have emerged and been applied in clinical practice. Jejunal interstitial reconstruction is one of the widely used anti-reflux surgical methods in clinical practice at present, but there is a lack of standardized guidance in terms of application indications and operation procedures. This consensus was formulated based on the latest evidence-based medical evidence and after multiple expert discussions, aiming to provide reference and guidance for clinicians in choosing proximal gastrectomy and jejunal interstitial reconstruction.

近年来,早期胃癌和近端胃癌的比例上升,保功能胃切除术越来越受到重视。近端胃切除术也被高度重视。反流性食管炎是近端胃切除术后消化道重建中不可忽视的问题。为此,一系列抗反流手术方法应运而生,并在临床中得到应用。空肠间质重建是目前临床广泛应用的抗反流手术方法之一,但在应用适应症和操作规程方面缺乏规范的指导。本共识是基于最新的循证医学证据,经过多次专家讨论而形成的,旨在为临床医生选择近端胃切除术和空肠间质重建提供参考和指导。
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引用次数: 0
[Laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis versus laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation: a multicenter retrospective cohort study]. [腹腔镜结肠次全切除术联合反蠕动结肠直肠吻合术与腹腔镜结肠全切除术联合回直肠吻合术治疗慢传输型便秘:一项多中心回顾性队列研究]。
Q3 Medicine Pub Date : 2025-12-25 DOI: 10.3760/cma.j.cn441530-20250830-00322
Y Luo, T T Hou, Y F Mu, C D Miao, T Y Gong, J Qin, D Y Wang, D W Song, H Li, S L Qin, R Cui, T F Wang, M Zhong, M H Yu
<p><p><b>Objective:</b> To compare postoperative anal function recovery between laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis and laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation. <b>Methods:</b> This multicenter retrospective cohort study enrolled patients meeting the following criteria: (1) severe constipation symptoms (<2 bowel movements/week), absent or insignificant defecation urge, abdominal distension, requiring laxatives to maintain bowel movements or laxatives being ineffective; (2) constipation symptoms for over 5 years, ineffective after >2 years of medical treatment, with strong desire for surgery; (3) significantly prolonged colon transit time (>72 hours) without significant gastric or small intestinal transit dysfunction; (4) no organic colonic lesions confirmed by colonoscopy and abdominal CT. Exclusion criteria: (1) patients undergoing open surgery; (2) exclusion of outlet obstruction constipation (e.g., rectocele, rectal prolapse, puborectalis spasm) by functional defecation MRI; (3) comorbid psychiatric disorders; (4) missing clinical data or loss to follow-up (postoperative follow-up <24 months). Based on these criteria, clinical and follow-up data were collected from 220 patients who underwent either laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSC group, <i>n</i> = 115) or laparoscopic total colectomy with ileorectal anastomosis (LTC group, <i>n</i> = 105) for slow transit constipation between January 2013 and December 2022. Subjective anal function (Constipation Severity Score and Wexner Fecal Incontinence Score) and objective anal function (positive rate of rectoanal inhibitory reflex [RAIR] and anorectal manometry) were observed preoperatively and at 6, 12, and 24 months postoperatively. <b>Results:</b> No significant differences were found in baseline characteristics between the two groups (all <i>P</i> >0.05). All surgeries were completed successfully without major significant complications. Subjective anal function assessment: At 24 months postoperatively, Constipation Severity Scores decreased significantly compared to preoperative scores in both groups [LSC group: (25.2±2.8) vs. (2.9±1.8), <i>P</i> <0.001; LTC group: (25.8±2.9) vs. (2.8±1.9), <i>P</i><0.001]. No significant differences were found between the groups at 6, 12, and 24 months postoperatively (all <i>P</i>>0.05). Wexner Fecal Incontinence Scores at 24 months were significantly lower than those at 6 months in both groups [LSC group: (12.9±1.8) vs. (3.9±2.5), <i>P</i><0.001; LTC group: (12.6±1.8) vs. (5.4±2.4), <i>P</i><0.001]. Although no significant difference was found at 6 months (<i>P</i> = 0.190), the LSC group had significantly lower Wexner scores than the LTC group at 12 and 24 months postoperatively (both <i>P</i> < 0.001). Objective anal function assessment: (1) Positive RAIR rate: Preoperative positive RAIR rates were 33.0% (38/115) in the LSC group
目的:比较腹腔镜结肠次全切除术联合反蠕动结肠直肠吻合术与腹腔镜结肠全切除术联合回直肠吻合术治疗慢传输型便秘术后肛门功能恢复情况。方法:本多中心回顾性队列研究纳入符合以下标准的患者:(1)便秘症状严重(用药2年,有强烈手术愿望;(3)结肠转运时间明显延长(>72小时),无明显胃或小肠转运功能障碍;(4)结肠镜及腹部CT证实无器质性结肠病变。排除标准:(1)开腹手术患者;(2)功能性排便MRI排除出口梗阻性便秘(如直肠前突、直肠脱垂、耻骨直肠痉挛);(3)共病性精神障碍;(4) 2013年1月至2022年12月期间因慢传输型便秘缺失临床资料或随访缺失(术后随访n = 115)或腹腔镜全结肠切除术合并回直肠吻合术(LTC组n = 105)。术前、术后6、12、24个月分别观察主观肛门功能(便秘严重程度评分和Wexner大便失禁评分)和客观肛门功能(直肠抑制反射阳性率和肛门直肠测压)。结果:两组患者基线特征差异无统计学意义(P < 0.05)。所有手术均顺利完成,无重大并发症。主观肛门功能评估:术后24个月,两组便秘严重程度评分较术前明显下降[LSC组:(25.2±2.8)比(2.9±1.8),P < 0.05]。两组患者术后24个月Wexner大便失禁评分均显著低于6个月[LSC组:(12.9±1.8)比(3.9±2.5),PPP = 0.190], LSC组术后12个月和24个月Wexner评分均显著低于LTC组(P均< 0.001)。客观肛门功能评估:(1)RAIR阳性率:LSC组术前RAIR阳性率为33.0% (38/115),LTC组术前RAIR阳性率为25.7% (27/105)(P < 0.05)。24个月时,两组的阳性率均显著升高[LSC: 66.1% (76/115);LTC: 63.8%(67/105)]与术前相比(两者均为0.05)。(2)静息压(RP)、挤压压(SP):术前RP、SP组间差异无统计学意义(P < 0.05)。术后6、12个月,LSC组RP、SP明显高于LTC组(p < 0.05)。结论:腹腔镜结肠次全切除术联合反蠕动结肠直肠吻合术和腹腔镜结肠全切除术联合回直肠吻合术治疗慢传输型便秘是安全的。然而,腹腔镜结肠次全切除术与反蠕动结肠直肠吻合术提供了良好的术后肛门功能恢复。
{"title":"[Laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis versus laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation: a multicenter retrospective cohort study].","authors":"Y Luo, T T Hou, Y F Mu, C D Miao, T Y Gong, J Qin, D Y Wang, D W Song, H Li, S L Qin, R Cui, T F Wang, M Zhong, M H Yu","doi":"10.3760/cma.j.cn441530-20250830-00322","DOIUrl":"10.3760/cma.j.cn441530-20250830-00322","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To compare postoperative anal function recovery between laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis and laparoscopic total colectomy with ileorectal anastomosis for slow transit constipation. &lt;b&gt;Methods:&lt;/b&gt; This multicenter retrospective cohort study enrolled patients meeting the following criteria: (1) severe constipation symptoms (&lt;2 bowel movements/week), absent or insignificant defecation urge, abdominal distension, requiring laxatives to maintain bowel movements or laxatives being ineffective; (2) constipation symptoms for over 5 years, ineffective after &gt;2 years of medical treatment, with strong desire for surgery; (3) significantly prolonged colon transit time (&gt;72 hours) without significant gastric or small intestinal transit dysfunction; (4) no organic colonic lesions confirmed by colonoscopy and abdominal CT. Exclusion criteria: (1) patients undergoing open surgery; (2) exclusion of outlet obstruction constipation (e.g., rectocele, rectal prolapse, puborectalis spasm) by functional defecation MRI; (3) comorbid psychiatric disorders; (4) missing clinical data or loss to follow-up (postoperative follow-up &lt;24 months). Based on these criteria, clinical and follow-up data were collected from 220 patients who underwent either laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSC group, &lt;i&gt;n&lt;/i&gt; = 115) or laparoscopic total colectomy with ileorectal anastomosis (LTC group, &lt;i&gt;n&lt;/i&gt; = 105) for slow transit constipation between January 2013 and December 2022. Subjective anal function (Constipation Severity Score and Wexner Fecal Incontinence Score) and objective anal function (positive rate of rectoanal inhibitory reflex [RAIR] and anorectal manometry) were observed preoperatively and at 6, 12, and 24 months postoperatively. &lt;b&gt;Results:&lt;/b&gt; No significant differences were found in baseline characteristics between the two groups (all &lt;i&gt;P&lt;/i&gt; &gt;0.05). All surgeries were completed successfully without major significant complications. Subjective anal function assessment: At 24 months postoperatively, Constipation Severity Scores decreased significantly compared to preoperative scores in both groups [LSC group: (25.2±2.8) vs. (2.9±1.8), &lt;i&gt;P&lt;/i&gt; &lt;0.001; LTC group: (25.8±2.9) vs. (2.8±1.9), &lt;i&gt;P&lt;/i&gt;&lt;0.001]. No significant differences were found between the groups at 6, 12, and 24 months postoperatively (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). Wexner Fecal Incontinence Scores at 24 months were significantly lower than those at 6 months in both groups [LSC group: (12.9±1.8) vs. (3.9±2.5), &lt;i&gt;P&lt;/i&gt;&lt;0.001; LTC group: (12.6±1.8) vs. (5.4±2.4), &lt;i&gt;P&lt;/i&gt;&lt;0.001]. Although no significant difference was found at 6 months (&lt;i&gt;P&lt;/i&gt; = 0.190), the LSC group had significantly lower Wexner scores than the LTC group at 12 and 24 months postoperatively (both &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Objective anal function assessment: (1) Positive RAIR rate: Preoperative positive RAIR rates were 33.0% (38/115) in the LSC group","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 12","pages":"1426-1433"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prognostic analysis of local excision in 153 cases of locally advanced low rectal cancer following neoadjuvant therapy]. 153例局部晚期低位直肠癌局部切除经新辅助治疗的预后分析。
Q3 Medicine Pub Date : 2025-11-25 DOI: 10.3760/cma.j.cn441530-20250406-00318
H F Pan, J H Ye, H Y Zhu, X J Wang, Y W Sun, Z F Chen, Z B Xu, S H Huang, W Z Jiang, P Chi, Y Huang
<p><p><b>Objective:</b> To evaluate the short-term and long-term outcomes of patients with locally advanced low rectal cancer who achieved clinical complete response (cCR) or near-clinical complete response (near-cCR) after neoadjuvant chemoradiotherapy (nCRT) and then underwent local excision. <b>Methods:</b> This was a descriptive case series study. Clinical data of patients with low rectal cancer who received neoadjuvant therapy, achieved cCR or near-cCR, underwent local excision, and had complete postoperative follow-up data were retrospectively analyzed. The study period was from May, 2015 to October, 2024, and the patients were treated at Fujian Medical University Union Hospital. Indications for local excision in this study were as follows: pathologically confirmed rectal adenocarcinoma, with the lower edge of the tumor ≤ 6 cm from the anal verge; maximum diameter of the lesion ≤ 2 cm after nCRT; no regional lymph node metastasis detected by transrectal endoscopic ultrasound (ERUS), pelvic magnetic resonance imaging (MRI), or positron emission tomography-computed tomography (PET-CT) after nCRT; MRI showing fibrosis of the primary lesion with a small amount of high signal on diffusion-weighted imaging (DWI), consistent with ymrT0-1 stage; serum carcinoembryonic antigen level within the normal range (< 5 μg/L) after nCRT; complicated with severe underlying diseases such as cardiovascular and cerebrovascular diseases and assessed as unable to tolerate radical surgery through comprehensive evaluation; and signed informed consent for local excision. The contraindications were: colonoscopic pathology indicating poorly differentiated adenocarcinoma or signet ring cell carcinoma; suspected lateral lymph node metastasis before neoadjuvant therapy; patients with residual lesions exceeding 3 cm in range after treatment. A total of 153 patients were included in this study, including 84 males and 69 females. The median age was 62 years, and the median distance from the tumor to the anal verge after neoadjuvant therapy was 4.0 cm. The short-term efficacy indicators of this study included postoperative complications of local excision and postoperative pathological results, and the long-term efficacy indicators included oncological prognosis (3-year cumulative local recurrence rate, 3-year cumulative distant metastasis rate, 3-year progression-free survival, and 3-year overall survival) and anal function at 1 year after surgery evaluated using the Low Anterior Resection Syndrome (LARS) scale where the total score is 42 points such that 0-20 points indicate no LARS, 21-29 points indicate mild LARS, and 30-42 points indicate severe LARS. <b>Results:</b> Postoperative pathology showed 122 cases (79.7%) of ypT0 stage, 10 cases (6.5%) of ypT1 stage, 18 cases (11.8%) of ypT2 stage, and 3 cases (2.0%) of ypT3 stage. The incidence of surgery-related complications was 42.5% (65/153), and the main complications included perianal pain (39.9%, 61/153), intestinal wall
目的:评价局部晚期低位直肠癌患者在新辅助放化疗(nCRT)后达到临床完全缓解(cCR)或接近临床完全缓解(near-临床完全缓解(near-临床完全缓解)后行局部切除的近期和长期预后。方法:采用描述性病例系列研究。回顾性分析经新辅助治疗、达到cCR或接近cCR、局部切除、术后随访完整的低位直肠癌患者的临床资料。研究时间为2015年5月至2024年10月,患者在福建医科大学协和医院就诊。本研究局部切除指征如下:病理证实的直肠腺癌,肿瘤下缘距肛缘≤6cm;nCRT后病变最大直径≤2 cm;经直肠内镜超声(ERUS)、盆腔磁共振成像(MRI)或正电子发射断层扫描-计算机断层扫描(PET-CT)未发现区域淋巴结转移;MRI示原发病灶纤维化,DWI呈少量高信号,与ymrT0-1期一致;nCRT后血清癌胚抗原水平在正常范围内(< 5 μg/L);合并心脑血管疾病等严重基础疾病,经综合评价不能耐受根治性手术者;并签署了局部切除的知情同意书。禁忌症为:结肠镜病理提示低分化腺癌或印戒细胞癌;新辅助治疗前怀疑外侧淋巴结转移;治疗后残余病灶范围超过3cm者。本研究共纳入153例患者,其中男性84例,女性69例。中位年龄62岁,新辅助治疗后肿瘤至肛门边缘的中位距离为4.0 cm。本研究的近期疗效指标包括局部切除术后并发症及术后病理结果,远期疗效指标包括肿瘤预后(3年累积局部复发率、3年累积远处转移率、3年无进展生存期、术后1年肛门功能评分采用低前切除综合征(LARS)量表,总分为42分,其中0-20分表示无LARS, 21-29分表示轻度LARS, 30-42分表示严重LARS。结果:术后病理显示:ypT0期122例(79.7%),ypT1期10例(6.5%),ypT2期18例(11.8%),ypT3期3例(2.0%)。手术相关并发症发生率为42.5%(65/153),主要并发症为肛周疼痛(39.9%,61/153)、肠壁切口开裂(21.6%,33/153)、肠壁切口感染(18.3%,28/153)。术前接受低分割放疗并发生肠壁切口裂开的患者比例为65.2%(15/23),高于常规长疗程组(13.6%,16/118)和短疗程组(16.7%,2/12)(χ2=30.55, P2=25.66, p)。局部晚期低位直肠癌患者经新辅助治疗后达到cCR或接近cCR,局部切除可获得良好的肿瘤预后和肛门功能保存效果;然而,并发症的发生率相对较高。
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引用次数: 0
[Perioperative digital surveillance with a multiparameter vital signs monitoring system in a gastric cancer patient with diabetes]. [1例胃癌合并糖尿病患者围手术期数字监护多参数生命体征监测系统]。
Q3 Medicine Pub Date : 2025-11-25 DOI: 10.3760/cma.j.cn441530-20250102-00003
Reziya Aierken, Z W Jiang, G W Gong, P Li, X Y Liu, F Ji

Objective: To evaluate the application value of a digital technology-based multiparameter vital signs monitoring system in perioperative comprehensive full-cycle surveillance. Methods: A comprehensive multidimensional vital signs monitoring system was developed through the integration of medical-grade wireless wearable devices, incorporating patch-type ambulatory electrocardiographic monitor, continuous glucose monitoring sensor, pulse oximeter, wireless digital thermometer, smart wristband, and bioelectrical impedance analyzer. This system facilitates continuous real-time acquisition of multiple physiological parameters including electrocardiogram, blood glucose, oxygen saturation, body temperature, physical activity, and body composition indices. The acquired data were systematically integrated and analyzed through a four-level digital architecture consisting of nurse mobile interfaces, bedside patient terminals, centralized ward monitoring displays, and hospital management information systems. One patient with gastric cancer complicated by diabetes mellitus was selected for full-cycle digital monitoring from preoperative evaluation to hospital discharge. The technical performance of the monitoring system was assessed in terms of data acquisition continuity and timeliness of abnormal event alerts. Results: The monitoring system effectively identified early postoperative abnormalities, such as decreased oxygen saturation and blood glucose fluctuations, providing timely guidance for clinical intervention. The built-in algorithm enabled visualization of perioperative stress levels through heart rate variability indices and continuous glucose monitoring data. The patient demonstrated good compliance with early postoperative mobilization, and the satisfaction score for monitoring management was 4 points based on the Likert 5-point scale. Conclusions: The multiparameter vital signs monitoring system enhanced the precision of perioperative management through continuous and dynamic physiological status assessment. Its modular design aligns with the principles of enhanced recovery after surgery, offering a novel technological solution for intelligent perioperative management.

目的:评价基于数字技术的多参数生命体征监测系统在围手术期全周期综合监测中的应用价值。方法:将贴片式动态心电图监护仪、连续血糖监测传感器、脉搏血氧仪、无线数字体温计、智能腕带、生物电阻抗分析仪等集成到医疗级无线可穿戴设备中,开发一套综合性多维生命体征监测系统。该系统可实现心电图、血糖、血氧饱和度、体温、体力活动、身体成分等多种生理参数的连续实时采集。通过由护士移动界面、床边患者终端、病房集中监控显示器和医院管理信息系统组成的四级数字架构,对采集的数据进行系统集成和分析。选择1例胃癌合并糖尿病患者,从术前评估到出院进行全周期数字化监测。从数据采集的连续性和异常事件报警的及时性两个方面对监测系统的技术性能进行了评估。结果:监测系统能有效识别术后早期异常,如血氧饱和度下降、血糖波动等,及时指导临床干预。内置算法通过心率变异性指数和连续血糖监测数据实现围手术期应激水平的可视化。患者术后早期活动依从性良好,根据Likert 5分制,监测管理满意度评分为4分。结论:多参数生命体征监测系统通过持续动态的生理状态评估,提高围手术期管理的准确性。其模块化设计符合增强术后恢复的原则,为智能围手术期管理提供了一种新颖的技术解决方案。
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引用次数: 0
[Impact of tumor circumferential location on prognosis in mid-low rectal cancer: a propensity- score-matched analysis]. [肿瘤周向位置对中低位直肠癌预后的影响:倾向-评分匹配分析]。
Q3 Medicine Pub Date : 2025-11-25 DOI: 10.3760/cma.j.cn441530-20250619-00230
W D Jiang, S H Li, S Y Li, Z Lou, W Zhang
<p><p><b>Objective:</b> To investigate the impact of circumferential tumor location (anterior wall, nonanterior wall, or circumferential) on circumferential resection margin (CRM) status, local recurrence, and survival in patients with mid-low rectal cancer. <b>Methods:</b> A retrospective cohort study was conducted using data from 696 patients with mid-low rectal adenocarcinoma who underwent surgery in the Department of Colorectal Surgery at the First Affiliated Hospital of Naval Medical University between December, 2018 and December, 2019. Based on MRI or contrast-enhanced CT findings, the rectal wall was divided into four quadrants: anterior, posterior, left, and right. Tumors were classified into three groups: anterior wall group (<i>n</i> = 245), nonanterior wall group (<i>n</i> = 286, tumors predominantly located on the posterior or lateral walls), and circumferential group (<i>n</i> = 165, tumors involving ≥ 3/4 of the circumference). Propensity score matching (PSM) was used to balance baseline characteristics. Outcomes included pathological CRM positivity, local recurrence rate (LRR), overall survival (OS), and disease-free survival (DFS). Cox regression analysis was performed to identify risk factors for recurrence, and subgroup analysis was conducted in patients who did not receive neoadjuvant therapy. <b>Results:</b> After PSM, both the anterior and circumferential groups had significantly higher pathological CRM positivity rates compared to the nonanterior wall group (<i>P</i>=0.040 and <i>P</i>=0.039, respectively). The median follow-up time was 64 months (range: 1-71 months). Compared to the nonanterior wall group, the anterior wall group also had a significantly higher 5-year LRR (8.8% vs. 2.3%, <i>P</i>=0.003), and significantly lower 5-year OS (80.7% vs. 91.6%, <i>P</i>=0.001) and DFS (76.6% vs. 84.6%, <i>P</i>=0.029). The circumferential group had a significantly higher 5-year LRR than the nonanterior wall group (11.4% vs. 3.8%, <i>P</i>=0.020), but no significant differences were observed in 5-year OS (81.8% vs. 89.5%, <i>P</i>=0.100) or DFS (70.7% vs. 78.3%, <i>P</i>=0.101). No significant differences were found between the anterior and circumferential groups in 5-year LRR (11.1% vs. 9.7%), OS (76.3% vs. 83.7%), or DFS (69.8% vs. 74.1%) either (all <i>P</i>>0.05). Cox univariate analysis and multivariate analysis identified anterior wall tumors (HR=3.751, 95%CI: 1.373-10.215, <i>P</i>=0.010), circumferential tumors (HR=3.240, 95%CI: 1.109-9.466, <i>P</i>=0.032), pathological CRM positivity (HR=3.071, 95%CI: 1.144-8.245, <i>P</i>=0.026), and lymph node metastasis (HR=2.584, 95%CI: 1.192-5.601, <i>P</i>=0.016) as independent risk factors for LRR. Conversely, a greater distance from tumor to the anal verge (per 1 cm increase, HR=0.831, 95%CI: 0.712-0.970, <i>P</i>=0.019), and neoadjuvant therapy (HR=0.442, 95%CI: 0.204-0.957, <i>P</i>=0.038) were identified as independent protective factors against LRR. In patients who did not re
目的:探讨肿瘤环周位置(前壁、非前壁、环周)对中低位直肠癌患者环周切除缘(CRM)状态、局部复发及生存的影响。方法:回顾性队列研究2018年12月至2019年12月在海军医科大学第一附属医院结直肠外科接受手术治疗的696例中低位直肠腺癌患者。根据MRI或CT增强检查结果,将直肠壁分为四个象限:前、后、左、右。肿瘤分为前壁组(245例)、非前壁组(286例,肿瘤主要位于后壁或侧壁)和周向组(165例,肿瘤累及≥3/4周长)。倾向评分匹配(PSM)用于平衡基线特征。结果包括病理性CRM阳性、局部复发率(LRR)、总生存期(OS)和无病生存期(DFS)。采用Cox回归分析确定复发危险因素,对未接受新辅助治疗的患者进行亚组分析。结果:PSM后,前壁组和环壁组的病理CRM阳性率均显著高于非前壁组(P=0.040和P=0.039)。中位随访时间64个月(范围:1-71个月)。与非前壁组相比,前壁组5年LRR (8.8% vs. 2.3%, P=0.003)显著升高,5年OS (80.7% vs. 91.6%, P=0.001)和DFS (76.6% vs. 84.6%, P=0.029)显著降低。环壁组5年LRR明显高于非前壁组(11.4%比3.8%,P=0.020),但5年OS(81.8%比89.5%,P=0.100)和DFS(70.7%比78.3%,P=0.101)差异无统计学意义。在5年LRR (11.1% vs. 9.7%)、OS (76.3% vs. 83.7%)和DFS (69.8% vs. 74.1%)方面,前路组和环路组之间均无显著差异(均P < 0.05)。Cox单因素分析和多因素分析发现,前壁肿瘤(HR=3.751, 95%CI: 1.373 ~ 10.215, P=0.010)、周周肿瘤(HR=3.240, 95%CI: 1.109 ~ 9.466, P=0.032)、病理性CRM阳性(HR=3.071, 95%CI: 1.144 ~ 8.245, P=0.026)、淋巴结转移(HR=2.584, 95%CI: 1.192 ~ 5.601, P=0.016)是LRR的独立危险因素。相反,肿瘤到肛门边缘的距离(每增加1 cm, HR=0.831, 95%CI: 0.712-0.970, P=0.019)和新辅助治疗(HR=0.442, 95%CI: 0.204-0.957, P=0.038)被认为是LRR的独立保护因素。在未接受新辅助治疗的患者中,局部晚期非前壁肿瘤的LRR明显较低(病理II-III期为1.3%,pT3-4期为1.6%)。结论:直肠肿瘤位于前壁或累及直肠周长与CRM阳性率高、局部复发率高、生存率低相关。这些患者应优先接受新辅助治疗。相比之下,非前壁肿瘤复发率低,对于这些病例可考虑选择性省略新辅助治疗。
{"title":"[Impact of tumor circumferential location on prognosis in mid-low rectal cancer: a propensity- score-matched analysis].","authors":"W D Jiang, S H Li, S Y Li, Z Lou, W Zhang","doi":"10.3760/cma.j.cn441530-20250619-00230","DOIUrl":"https://doi.org/10.3760/cma.j.cn441530-20250619-00230","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the impact of circumferential tumor location (anterior wall, nonanterior wall, or circumferential) on circumferential resection margin (CRM) status, local recurrence, and survival in patients with mid-low rectal cancer. &lt;b&gt;Methods:&lt;/b&gt; A retrospective cohort study was conducted using data from 696 patients with mid-low rectal adenocarcinoma who underwent surgery in the Department of Colorectal Surgery at the First Affiliated Hospital of Naval Medical University between December, 2018 and December, 2019. Based on MRI or contrast-enhanced CT findings, the rectal wall was divided into four quadrants: anterior, posterior, left, and right. Tumors were classified into three groups: anterior wall group (&lt;i&gt;n&lt;/i&gt; = 245), nonanterior wall group (&lt;i&gt;n&lt;/i&gt; = 286, tumors predominantly located on the posterior or lateral walls), and circumferential group (&lt;i&gt;n&lt;/i&gt; = 165, tumors involving ≥ 3/4 of the circumference). Propensity score matching (PSM) was used to balance baseline characteristics. Outcomes included pathological CRM positivity, local recurrence rate (LRR), overall survival (OS), and disease-free survival (DFS). Cox regression analysis was performed to identify risk factors for recurrence, and subgroup analysis was conducted in patients who did not receive neoadjuvant therapy. &lt;b&gt;Results:&lt;/b&gt; After PSM, both the anterior and circumferential groups had significantly higher pathological CRM positivity rates compared to the nonanterior wall group (&lt;i&gt;P&lt;/i&gt;=0.040 and &lt;i&gt;P&lt;/i&gt;=0.039, respectively). The median follow-up time was 64 months (range: 1-71 months). Compared to the nonanterior wall group, the anterior wall group also had a significantly higher 5-year LRR (8.8% vs. 2.3%, &lt;i&gt;P&lt;/i&gt;=0.003), and significantly lower 5-year OS (80.7% vs. 91.6%, &lt;i&gt;P&lt;/i&gt;=0.001) and DFS (76.6% vs. 84.6%, &lt;i&gt;P&lt;/i&gt;=0.029). The circumferential group had a significantly higher 5-year LRR than the nonanterior wall group (11.4% vs. 3.8%, &lt;i&gt;P&lt;/i&gt;=0.020), but no significant differences were observed in 5-year OS (81.8% vs. 89.5%, &lt;i&gt;P&lt;/i&gt;=0.100) or DFS (70.7% vs. 78.3%, &lt;i&gt;P&lt;/i&gt;=0.101). No significant differences were found between the anterior and circumferential groups in 5-year LRR (11.1% vs. 9.7%), OS (76.3% vs. 83.7%), or DFS (69.8% vs. 74.1%) either (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). Cox univariate analysis and multivariate analysis identified anterior wall tumors (HR=3.751, 95%CI: 1.373-10.215, &lt;i&gt;P&lt;/i&gt;=0.010), circumferential tumors (HR=3.240, 95%CI: 1.109-9.466, &lt;i&gt;P&lt;/i&gt;=0.032), pathological CRM positivity (HR=3.071, 95%CI: 1.144-8.245, &lt;i&gt;P&lt;/i&gt;=0.026), and lymph node metastasis (HR=2.584, 95%CI: 1.192-5.601, &lt;i&gt;P&lt;/i&gt;=0.016) as independent risk factors for LRR. Conversely, a greater distance from tumor to the anal verge (per 1 cm increase, HR=0.831, 95%CI: 0.712-0.970, &lt;i&gt;P&lt;/i&gt;=0.019), and neoadjuvant therapy (HR=0.442, 95%CI: 0.204-0.957, &lt;i&gt;P&lt;/i&gt;=0.038) were identified as independent protective factors against LRR. In patients who did not re","PeriodicalId":23959,"journal":{"name":"中华胃肠外科杂志","volume":"28 11","pages":"1267-1279"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical value of local excision in locally advanced rectal cancer under the context of neoadjuvant immunotherapy]. 【新辅助免疫治疗下局部晚期直肠癌局部切除的临床价值】。
Q3 Medicine Pub Date : 2025-11-25 DOI: 10.3760/cma.j.cn441530-20250815-00306
J L Zhou, G L Lin

The integration of immunotherapy into neoadjuvant treatment for locally advanced rectal cancer has markedly increased complete response rates, offering greater potential for organ preservation. However, the reduced restaging accuracy after immunotherapy has limited the applicability of the watch-and-wait strategy. As an organ-preserving approach that enables residual lesion removal and pathological assessment, local excision not only reduces the risk of local regrowth associated with watch-and-wait, but also enables full-thickness tumor bed sampling to determine pathological stage, regression pattern, and molecular characteristics, thereby supporting risk stratification and individualized decision-making. Moving forward, local excision is expected to achieve precise, risk-adapted organ preservation by optimizing surgical timing and techniques, and integrating multimodal parameters including imaging, pathology, and the tumor microenvironment, ultimately attaining the dual aim of maximizing both oncologic efficacy and functional preservation.

局部晚期直肠癌的免疫治疗与新辅助治疗的结合显著提高了完全缓解率,为器官保存提供了更大的潜力。然而,免疫治疗后重新定位准确性的降低限制了观察和等待策略的适用性。局部切除是一种保留器官的方法,可以去除残余病变并进行病理评估,不仅可以降低观察等待相关的局部再生风险,还可以通过全层肿瘤床取样确定病理分期、消退模式和分子特征,从而支持风险分层和个性化决策。展望未来,局部切除有望通过优化手术时机和技术,并整合包括影像学、病理学和肿瘤微环境在内的多模态参数,实现精确的、适应风险的器官保存,最终实现肿瘤疗效和功能保存最大化的双重目标。
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引用次数: 0
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中华胃肠外科杂志
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