Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_085
Natalya Pahomova
{"title":"Теоретические основы интеграции пожилых граждан в региональное образовательное пространство","authors":"Natalya Pahomova","doi":"10.52376/978-5-907541-95-5_085","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_085","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74488855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_223
Olga Arefeva, Vyacheslav Utemov
{"title":"Развитие мотивации к познанию младших школьников «Живая математика»","authors":"Olga Arefeva, Vyacheslav Utemov","doi":"10.52376/978-5-907541-95-5_223","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_223","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88154307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_204
A. Sergei, Andrei Nasledov, Lubov Tkacheva
{"title":"Разработка шкалы риска расстройства аутистического спектра (РАС) у детей 3-4 лет","authors":"A. Sergei, Andrei Nasledov, Lubov Tkacheva","doi":"10.52376/978-5-907541-95-5_204","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_204","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87076619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_097
Sardana Timofeeva, Gyryjapovna Stalina
{"title":"О лучших практиках среди учреждений социального обслуживания семьи и детей в Республике Саха (Якутия)","authors":"Sardana Timofeeva, Gyryjapovna Stalina","doi":"10.52376/978-5-907541-95-5_097","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_097","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87091523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_062
S. Aleksandrova, Anna Vinokyrova, Mariya Prokopeva
{"title":"Подготовка кадров - тьюторов семьи как важное направление государственной семейной политики в Республике Саха (Якутия)","authors":"S. Aleksandrova, Anna Vinokyrova, Mariya Prokopeva","doi":"10.52376/978-5-907541-95-5_062","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_062","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75228159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_214
A. Popova, Oksana Gavrileva, Vasilii Nahodkin
{"title":"Актуальность работы бизнес-психолога в современном обществе","authors":"A. Popova, Oksana Gavrileva, Vasilii Nahodkin","doi":"10.52376/978-5-907541-95-5_214","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_214","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74479784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_049
Elizaveta Roeva
{"title":"Роль семьи и школы для саморазвития и самореализации младших школьников","authors":"Elizaveta Roeva","doi":"10.52376/978-5-907541-95-5_049","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_049","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74401179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.58168/prtow2022_90-94
E. Snyatkov, M. Savinkov
{"title":"INVESTIGATION OF THE CAUSES OF THE ICE FAILURE OF THE FORKLIFT LOADER HELI CPCD18-KU11H ACCORDING TO THE PROVIDED DETAILS","authors":"E. Snyatkov, M. Savinkov","doi":"10.58168/prtow2022_90-94","DOIUrl":"https://doi.org/10.58168/prtow2022_90-94","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74867428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.21626/vestnik/2022-4/12
L. Novikova, E. Dontsova, A. Chernov, O. Saurina, Vladimir G. Dontsov, L. Borzunova, Tamara I. Pogodaeva
Objective: to study changes in immunological parameters in patients with true eczema during complex therapy with the use of upadacitinib. Materials and methods. The work was performed with the participation of 131 patients aged 18 to 70 years (average age 58.7±3.6 years) with a diagnosis of true eczema, who were on inpatient treatment. The patients were divided into 4 groups: the first group received basic drug therapy (BMT), the second - phototherapy (FT) and BMT (BMT+FT), the third - upadacitinib (UPA) and BMT (BMT+ UPA), the fourth - BMT+FT+UPA. The content of IL-1ß, IL-2, IL-6, IL-10, INF-γ, TNF-α in the blood serum of patients was determined by enzyme immunoassay before the start of treatment and 2 and 4 months after its start. Results. Before the start of treatment, the values of IL-1ß, IL-2, IL-6, IL-10, INF-γ, TNF-α in the blood serum of patients in comparison with healthy individuals were significantly increased (3.7-4.2 times) against the background of a decrease in the level of IL-10 (2 times). In patients of the first group, the cytokine level did not change significantly after 2 and 4 months from the start of treatment in comparison with the indicators before the start of treatment. In the second group, at all follow-up periods, the content of IL-10 significantly increased with a decrease in the levels of IL-1ß, IL-2 and IL-6. When using UPA in the third group, the content of IL-10 increased against the background of a marked decrease in all other cytokines studied. The greatest changes were noted in the fourth group during the complex treatment of UPA with FT and BMT: a significantly significant decrease in the levels of IL-1, IL-2, IL-6, INF-γ, TNF-α (by 53-67%, p<0.001) against the background of an increase in the content of IL-10 (by 69%, p<0.001). The preservation of the orientation and severity of the identified shifts after 4 months indicates their stability. Conclusion. In patients with true eczema, the use of upadacitinib as part of complex treatment in combination with basic drug therapy and phototherapy causes a pronounced and prolonged correction of the cytokine profile in the blood.
目的:研究upadacitinib复合治疗真湿疹患者免疫参数的变化。材料和方法。131例年龄在18 ~ 70岁(平均年龄58.7±3.6岁)，诊断为真正湿疹的住院患者参与了这项工作。将患者分为4组:第一组采用基础药物治疗(BMT)，第二组采用光疗(FT) + BMT (BMT+FT)，第三组采用upadacitinib (UPA) + BMT (BMT+ UPA)，第四组采用BMT+FT+UPA。采用酶免疫分析法测定治疗开始前及治疗开始后2、4个月患者血清中IL-1ß、IL-2、IL-6、IL-10、INF-γ、TNF-α的含量。结果。治疗开始前，患者血清中IL-1ß、IL-2、IL-6、IL-10、INF-γ、TNF-α值较健康者显著升高(3.7 ~ 4.2倍)，而IL-10水平降低(2倍)。第一组患者在治疗开始后2个月和4个月的细胞因子水平与治疗开始前的指标相比无明显变化。第二组在随访期间，IL-10含量显著升高，IL-1ß、IL-2、IL-6水平降低。当在第三组中使用UPA时，IL-10的含量增加，而所有其他细胞因子的含量都显着下降。第四组在联合FT和BMT治疗UPA期间变化最大:IL-1、IL-2、IL-6、INF-γ、TNF-α水平显著降低(53-67%，p<0.001)，而IL-10含量升高(69%，p<0.001)。确定的移位方向和严重程度在4个月后保持不变表明其稳定性。结论。在真正的湿疹患者中，使用upadacitinib作为复杂治疗的一部分，与基本药物治疗和光疗相结合，导致血液中细胞因子谱的显著和长期纠正。
{"title":"Changes in cytokine levels in the blood of eczema patients with complex treatment with upadacitinib","authors":"L. Novikova, E. Dontsova, A. Chernov, O. Saurina, Vladimir G. Dontsov, L. Borzunova, Tamara I. Pogodaeva","doi":"10.21626/vestnik/2022-4/12","DOIUrl":"https://doi.org/10.21626/vestnik/2022-4/12","url":null,"abstract":"Objective: to study changes in immunological parameters in patients with true eczema during complex therapy with the use of upadacitinib. Materials and methods. The work was performed with the participation of 131 patients aged 18 to 70 years (average age 58.7±3.6 years) with a diagnosis of true eczema, who were on inpatient treatment. The patients were divided into 4 groups: the first group received basic drug therapy (BMT), the second - phototherapy (FT) and BMT (BMT+FT), the third - upadacitinib (UPA) and BMT (BMT+ UPA), the fourth - BMT+FT+UPA. The content of IL-1ß, IL-2, IL-6, IL-10, INF-γ, TNF-α in the blood serum of patients was determined by enzyme immunoassay before the start of treatment and 2 and 4 months after its start. Results. Before the start of treatment, the values of IL-1ß, IL-2, IL-6, IL-10, INF-γ, TNF-α in the blood serum of patients in comparison with healthy individuals were significantly increased (3.7-4.2 times) against the background of a decrease in the level of IL-10 (2 times). In patients of the first group, the cytokine level did not change significantly after 2 and 4 months from the start of treatment in comparison with the indicators before the start of treatment. In the second group, at all follow-up periods, the content of IL-10 significantly increased with a decrease in the levels of IL-1ß, IL-2 and IL-6. When using UPA in the third group, the content of IL-10 increased against the background of a marked decrease in all other cytokines studied. The greatest changes were noted in the fourth group during the complex treatment of UPA with FT and BMT: a significantly significant decrease in the levels of IL-1, IL-2, IL-6, INF-γ, TNF-α (by 53-67%, p<0.001) against the background of an increase in the content of IL-10 (by 69%, p<0.001). The preservation of the orientation and severity of the identified shifts after 4 months indicates their stability. Conclusion. In patients with true eczema, the use of upadacitinib as part of complex treatment in combination with basic drug therapy and phototherapy causes a pronounced and prolonged correction of the cytokine profile in the blood.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74856274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.52376/978-5-907541-95-5_012
Paraskovya Basova, O. Protopopova
{"title":"Проектная деятельность как эффективная технология социальной реабилитации семей с детьми, находящимися в трудной жизненной ситуации и социально опасном положении","authors":"Paraskovya Basova, O. Protopopova","doi":"10.52376/978-5-907541-95-5_012","DOIUrl":"https://doi.org/10.52376/978-5-907541-95-5_012","url":null,"abstract":"","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84124187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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