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Курский научно-практический вестник «Человек и его здоровье»最新文献

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Роль родителей в формировании здорового образа жизни у подростков 父母在塑造青少年健康生活方式方面的作用
Diana Dyakonova, S. Dmitrieva
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引用次数: 0
Morphofunctional status dynamics of female athletes who had COVID-19 during training in the middle altitude 中高海拔地区新冠肺炎女运动员训练过程中形态功能状态动态
Yu.V. Koryagina, Sergey V. Nopin, G. Ter-Akopov, S. M. Abutalimova
Objective: to examine the morphofunctional status dynamics of female athletes who had COVID-19 during training in the middle altitude. Materials and methods. The study of the morphofunctional status was conducted in the beginning and at the end of training camps in Kislovodsk at an altitude of 1240 meters. It included 78 elite female athletes during the preparatory period of the training process. We have identified the initial level and dynamics of the functional state of the cardiovascular and respiratory systems, heart rate variability and body composition. We have also carried out a questionnaire of the state and collected medical background about the COVID-19. Results. According to the data obtained, training in the middle attitude did not significantly influence the morphofunctional status of female athletes, both who had and who did not have COVID-19. All indicators were within physiological standards. The functional state dynamics of athletes was mostly connected to the response to mountain hypoxia, which in higher degree is shown in athletes with the third type of the heart rate autonomic regulation. The athletes who were ill with COVID-19 were slightly different (within normal limits) from those who were not in terms of body composition indicators, expiratory volume and rate, as well as blood pressure. The systemic analysis has demonstrated that the factor-based structure of variables of the morphofunctional status of female athletes who were ill with COVID is described with an increased correlation connection between structural and functional indicators, stress of the body’s adaptation. Conclusion. Despite the seemingly favorable morphofunctional status of female athletes, who had COVID-19, in terms of systemic connections it is still characterized with an emergency transitional process of adaptation, during which complication of various diseases is possible. It should be noted by working doctors in sports medicine and coaches working with athletes, especially in the middle altitude conditions.
目的:探讨中高海拔地区新冠肺炎女运动员训练过程中形态功能状态的动态变化。材料和方法。形态功能状态的研究是在海拔1240米的基斯洛沃茨克训练营开始和结束时进行的。它包括78名优秀的女运动员在训练过程的准备阶段。我们已经确定了心血管和呼吸系统功能状态的初始水平和动态,心率变异性和身体成分。我们还开展了国家问卷调查,收集了有关COVID-19的医学背景。结果。根据获得的数据,中位姿势训练对感染和未感染COVID-19的女运动员的形态功能状态没有显著影响。各项指标均在生理标准内。运动员的功能状态动力学主要与山地缺氧反应有关,在心率自主调节的第三类运动员中表现得更为明显。感染COVID-19的运动员在身体成分指标、呼气量和频率以及血压方面与未感染COVID-19的运动员略有不同(在正常范围内)。系统分析表明,新冠肺炎女运动员形态功能状态变量的因子结构描述为结构与功能指标、机体适应压力之间的相关性增加。结论。感染新冠肺炎的女运动员虽然形态功能状态看似良好,但在系统连接上仍具有适应的紧急过渡过程,在此过程中有可能并发各种疾病。运动医学的工作医生和与运动员一起工作的教练应该注意到这一点,特别是在中等海拔条件下。
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引用次数: 0
Гендерное воспитание как основа формирования семейных ценностей школьников 性别教育是塑造学生家庭价值观的基础。
M. Popova
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引用次数: 1
Инновационная модель сопровождения приемных семей «Колыбель семьи» 寄养家庭“摇篮”的创新模式
L. Efremova, Mariya Prokopeva
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引用次数: 0
Динамика особенностей общения детей младшего школьного возраста 学龄儿童交流特性动态
A. Kononova, Valeriya Sveshnikova, Vasilii Nahodkin
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引用次数: 0
DIRECTIONS OF DEVELOPMENT OF TECHNOLOGIES FOR DIAGNOSING MECHANICAL TRANSMISSIONS 机械传动诊断技术的发展方向
E. Timashov
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引用次数: 0
The relationship of alveolar-bronchiolar disorders with the level of interleukin-20 in patients with community-acquired pneumonia 社区获得性肺炎患者肺泡-细支气管疾病与白细胞介素-20水平的关系
S. Bondar, I. Terekhov, V. Parfenyuk, Nelli V. Bondar
Objective is to study the relationship between clinical, laboratory and radiological manifestations of alveolar-bronchiolar dysfunction with the production of interleukin-20 in patients with community-acquired pneumonia. Materials and methods. We examined 60 patients of both sexes aged 18 to 45 years with bacterial community-acquired pneumonia in the first 3 days of the disease, as well as 15 practically healthy individuals. The material of the study was venous blood, in the serum of which the concentration of interleukins (IL) was determined: IL-1β, -2, -4, -8, -10, -17A, -20, -28A, -33, tumor necrosis factor-alpha (TNFα), interferon-gamma (IFNγ), Clara cell protein (CCP), surfactant protein D (SP-D), prostacyclin (PgI2), soluble form of the Fas-receptor (sFas), and its ligand (sFasL), leukotriene D4 (LTD4), thromboxane A2 (TA2). Results. The development of pneumonia is accompanied by an increase in the production of the studied mediators, which is more pronounced in patients with a severe course of the disease. An increase in the concentration of IL-20 from the minimum to the maximum level is accompanied by a significant proportional decrease in the concentration of IL-1β, TNFα, IL-33, TA2, LTD4, Fas, FasL. A high level of IL-20 was associated with a decrease in the concentration of CCP, indicating a weakening of the alveolar-bronchiolar dysfunction and a decrease in the intensity of the inflammatory reaction in the lung tissue. It was also found that a high level of IL-20 was associated with increased production of PgI2, IFNγ, IL-1RA, IL-17A, IL-8, IL-4, IL-28A, IL-10, SLPI. Conclusion. The results of the study indicate the important role of IL-20 in the development of inflammation of the lower respiratory tract, which consists in regulating the activity of the acute phase response, modulating the production of prostacyclin and leukotrienes, determining the limitation of alveolar-bronchiolar dysfunction in patients with pneumonia, as well as the restriction of proapoptogenic influences that determine the decrease in volumes. tissue and cellular damage in such patients.
目的探讨社区获得性肺炎患者肺泡-细支气管功能障碍的临床、实验室及影像学表现与白细胞介素-20产生的关系。材料和方法。我们检查了60名年龄在18至45岁的男女细菌性社区获得性肺炎患者在疾病的前3天,以及15名实际上健康的个体。研究材料为静脉血,测定血清中白细胞介素(IL)的浓度:IL-1β、-2、-4、-8、-10、-17A、-20、-28A、-33、肿瘤坏死因子α (TNFα)、干扰素γ (IFNγ)、Clara细胞蛋白(CCP)、表面活性剂蛋白D (SP-D)、前列腺素(PgI2)、可溶性形式的fas受体(sFasL)及其配体(sFasL)、白三烯D4 (LTD4)、血栓素A2 (TA2)。结果。肺炎的发展伴随着所研究的介质产生的增加,这在病程严重的患者中更为明显。随着IL-20浓度从最低到最高水平的增加,IL-1β、TNFα、IL-33、TA2、LTD4、Fas、FasL的浓度呈显著比例下降。高水平IL-20与CCP浓度降低相关,表明肺泡-细支气管功能障碍减弱,肺组织炎症反应强度降低。研究还发现,高水平的IL-20与PgI2、IFNγ、IL-1RA、IL-17A、IL-8、IL-4、IL-28A、IL-10、SLPI的产生增加有关。结论。本研究结果表明IL-20在下呼吸道炎症发展中的重要作用,包括调节急性期反应的活性,调节前列环素和白三烯的产生,决定肺炎患者肺泡-细支气管功能障碍的局限性,以及决定体积减少的促凋亡影响的限制。这类病人的组织和细胞损伤
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引用次数: 0
Comparative pharmacoepidemiological characteristics of antibacterial drugs prescriptions used in patients with lower respiratory tract infection in a typical practice in Kursk and Chisinau 库尔斯克和基希讷乌典型病例下呼吸道感染患者抗菌药物处方的比较药物流行病学特征
S. Povetkin, Victor I. Gikavy, Oksana V. Levashova, A. A. Kornilov, Nicolae G. Bachinsky, Lilia A. Podgursky, L. M. Tsurkan, I. Saraev
Objective: to study the structure of medical prescriptions for antibacterial drugs used in patients with various types of infection of the bronchopulmonary system in the conditions of typical practice in Kursk (Russian Federation) and Chisinau (Republic of Moldova). Materials and methods. In order to assess the structure of prescribing various classes of antibacterial agents used to treat patients with infections of the respiratory system, a survey of doctors from medical organizations in Kursk and Chisinau was conducted in the period from October 2019. to January 2020 as a one-time descriptive study. As model diseases are taken: acute bronchitis with purulent sputum, exacerbation of chronic obstructive pulmonary disease with purulent sputum, non-severe community-acquired pneumonia. Results. The leaders in prescription for acute bronchitis with purulent sputum were cephalosporins: in Kursk, their share was 24% (cefixime was most often prescribed), and in Chisinau, 26.8% (leaders were cefixime and ceftriaxone). In patients with exacerbation of chronic obstructive pulmonary disease and purulent sputum, doctors from both cohorts also more often recommended cephalosporins: 29.4% and 36.1% for Kursk and Chisinau, respectively; among them, cefixime, ceftriaxone and cefotaxime were leaders in Kursk, while ceftriaxone, cefotaxime and cefuroxime axetil were the priorities in Chisinau. For non-severe community-acquired pneumonia, doctors in Kursk preferred macrolides (more often - azithromycin and clarithromycin), inhibitor-protected penicillins (more often - amoxicillin/clavulanate) and cephalosporins (mainly of the 3rd generation), in Chisinau, cephalosporins (mainly of the 3rd generation) and penicillins (including inhibitor-protected) were more often prescribed, the proportion of macrolides was significantly less. Conclusion. Doctors from Chisinau and Kursk implement pharmacotherapy for this group of patients in accordance with modern clinical guidelines; at the same time, cases of irrational use of certain medicines are recorded.
目的:研究俄罗斯库尔斯克市和摩尔多瓦共和国基希讷乌市典型实践条件下各类支气管肺系统感染患者抗菌药物处方结构。材料和方法。为了评估用于治疗呼吸系统感染患者的各类抗菌药物的处方结构,从2019年10月开始,对库尔斯克和基希讷乌医疗机构的医生进行了一项调查。到2020年1月,作为一次性描述性研究。作为模型疾病:急性支气管炎化脓性痰、慢性阻塞性肺疾病化脓性痰加重、非重度社区获得性肺炎。结果。急性支气管炎化脓性痰的处方以头孢菌素为主:库尔斯克市以头孢克肟为主,占24%;基希讷乌市以头孢克肟和头孢曲松为主,占26.8%。在慢性阻塞性肺疾病和脓性痰加重的患者中,两个队列的医生也更常推荐头孢菌素:库尔斯克和基希讷乌分别为29.4%和36.1%;其中,库尔斯克市以头孢克肟、头孢曲松、头孢噻肟为主,基希讷乌市以头孢曲松、头孢曲松、头孢呋辛酯为主。对于非重度社区获得性肺炎,库尔斯克市医生首选大环内酯类药物(多见于阿奇霉素和克拉霉素)、抑制剂保护青霉素类药物(多见于阿莫西林/克拉维酸)和头孢菌素类药物(以第3代为主),基希讷乌市较多使用头孢菌素类药物(多见于第3代)和青霉素类药物(含抑制剂保护),大环内酯类药物的使用比例明显较低。结论。基希讷乌和库尔斯克的医生根据现代临床指南对这组患者进行药物治疗;与此同时,对某些药物的不合理使用情况进行了记录。
{"title":"Comparative pharmacoepidemiological characteristics of antibacterial drugs prescriptions used in patients with lower respiratory tract infection in a typical practice in Kursk and Chisinau","authors":"S. Povetkin, Victor I. Gikavy, Oksana V. Levashova, A. A. Kornilov, Nicolae G. Bachinsky, Lilia A. Podgursky, L. M. Tsurkan, I. Saraev","doi":"10.21626/vestnik/2022-04/05","DOIUrl":"https://doi.org/10.21626/vestnik/2022-04/05","url":null,"abstract":"Objective: to study the structure of medical prescriptions for antibacterial drugs used in patients with various types of infection of the bronchopulmonary system in the conditions of typical practice in Kursk (Russian Federation) and Chisinau (Republic of Moldova). Materials and methods. In order to assess the structure of prescribing various classes of antibacterial agents used to treat patients with infections of the respiratory system, a survey of doctors from medical organizations in Kursk and Chisinau was conducted in the period from October 2019. to January 2020 as a one-time descriptive study. As model diseases are taken: acute bronchitis with purulent sputum, exacerbation of chronic obstructive pulmonary disease with purulent sputum, non-severe community-acquired pneumonia. Results. The leaders in prescription for acute bronchitis with purulent sputum were cephalosporins: in Kursk, their share was 24% (cefixime was most often prescribed), and in Chisinau, 26.8% (leaders were cefixime and ceftriaxone). In patients with exacerbation of chronic obstructive pulmonary disease and purulent sputum, doctors from both cohorts also more often recommended cephalosporins: 29.4% and 36.1% for Kursk and Chisinau, respectively; among them, cefixime, ceftriaxone and cefotaxime were leaders in Kursk, while ceftriaxone, cefotaxime and cefuroxime axetil were the priorities in Chisinau. For non-severe community-acquired pneumonia, doctors in Kursk preferred macrolides (more often - azithromycin and clarithromycin), inhibitor-protected penicillins (more often - amoxicillin/clavulanate) and cephalosporins (mainly of the 3rd generation), in Chisinau, cephalosporins (mainly of the 3rd generation) and penicillins (including inhibitor-protected) were more often prescribed, the proportion of macrolides was significantly less. Conclusion. Doctors from Chisinau and Kursk implement pharmacotherapy for this group of patients in accordance with modern clinical guidelines; at the same time, cases of irrational use of certain medicines are recorded.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89807476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial stiffness in patients with acute coronary syndrome without persistent ST segment elevation combined with chronic kidney disease and arterial hypertension and its correction with antihypertensive therapy 急性冠状动脉综合征合并慢性肾病合并高血压患者动脉僵硬及降压治疗
Pribylov Sergey A., Yakovleva Margarita V., Pribylov Vladislav S., Barbashina Tatiana A., Leonidova Kristina O., Pribylova Nadezda N.
Objective: to study arterial stiffness in patients with acute coronary syndrome without ST elevation, who have hypertension (AH) and stage 2-3A chronic kidney disease (CKD) and to assess the ability of angiotensin-converting enzyme inhibitor perindopril and angiotensin receptor antagonist losartan to reduce arterial stiffness in these patients. Materials and Methods. We studied 44 patients with ACS without ST elevation combined with CKD stage 2-3A, AH (the 1st group). The comparison groups were the ACS without ST segment elevation, AH patients with normal renal function (the 2nd group, n=27) and the 3rd group (n=44) of patients with chronic CHD, AH and CKD. Group 1 patients were divided into 2 subgroups taking perindopril or losartan. The parameters of vascular wall stiffness (pulse wave velocity (PWV), cardio-ankle vascular index (CAVI), ankle brachial index (ABI), aortic augmentation index (AI), central systolic and pulse aortic pressure, peripheral blood pressure (BP), estimated glomerular filtration rate (GFR) were assessed.) Results. The patients with ACS without ST elevation combined with 2-3A stages of CKD and AH had a significantly higher cPAP, AI, PWV, and CAVI than the patients of the 2nd group. During 3 months of complex therapy with perindopril, a decrease in PWV, cSAP, cPAP, AI was observed. There were no significant differences in the effects of perindopril and losartan on peripheral and central blood pressure, on renal function, on arterial stiffness parameters. Conclusion. Patients with AH and CKD stage 2-3A have more pronounced arterial stiffness compared to similar patients with normal GFR. Antihypertensive therapy with perindopril and losartan allows to reach target levels of peripheral BP, significantly reduce central aortic pressure and improve elastic properties of the arterial vascular wall.
目的:研究合并高血压(AH)和2-3A期慢性肾脏疾病(CKD)的急性冠状动脉综合征无ST段抬高患者的动脉僵硬度,并评估血管紧张素转换酶抑制剂perindopril和血管紧张素受体拮抗剂氯沙坦降低这些患者动脉僵硬度的能力。材料与方法。我们研究了44例ACS无ST段抬高合并CKD期2-3A, AH的患者(第一组)。对照组为无ST段抬高的ACS患者、肾功能正常的AH患者(第二组,n=27)和合并慢性冠心病、AH和CKD患者的第三组(n=44)。组1患者分为2个亚组,分别使用培哚普利或氯沙坦。评估血管壁刚度(脉搏波速度(PWV)、心踝血管指数(CAVI)、踝肱指数(ABI)、主动脉增强指数(AI)、中央收缩压和脉主动脉压、外周血压(BP)、肾小球滤过率(GFR)等参数。)结果。ACS无ST段抬高合并CKD、AH 2-3A期患者cPAP、AI、PWV、CAVI明显高于第二组患者。在培哚普利联合治疗3个月期间,观察到PWV、cSAP、cPAP、AI下降。培哚普利和氯沙坦对外周血和中枢血压、肾功能、动脉硬度参数的影响无显著差异。结论。与GFR正常的类似患者相比,AH和CKD 2-3A期患者有更明显的动脉僵硬。使用培哚普利和氯沙坦进行降压治疗可以使外周血压达到目标水平,显著降低中央主动脉压,改善动脉血管壁的弹性。
{"title":"Arterial stiffness in patients with acute coronary syndrome without persistent ST segment elevation combined with chronic kidney disease and arterial hypertension and its correction with antihypertensive therapy","authors":"Pribylov Sergey A., Yakovleva Margarita V., Pribylov Vladislav S., Barbashina Tatiana A., Leonidova Kristina O., Pribylova Nadezda N.","doi":"10.21626/vestnik/2022-1/03","DOIUrl":"https://doi.org/10.21626/vestnik/2022-1/03","url":null,"abstract":"Objective: to study arterial stiffness in patients with acute coronary syndrome without ST elevation, who have hypertension (AH) and stage 2-3A chronic kidney disease (CKD) and to assess the ability of angiotensin-converting enzyme inhibitor perindopril and angiotensin receptor antagonist losartan to reduce arterial stiffness in these patients. Materials and Methods. We studied 44 patients with ACS without ST elevation combined with CKD stage 2-3A, AH (the 1st group). The comparison groups were the ACS without ST segment elevation, AH patients with normal renal function (the 2nd group, n=27) and the 3rd group (n=44) of patients with chronic CHD, AH and CKD. Group 1 patients were divided into 2 subgroups taking perindopril or losartan. The parameters of vascular wall stiffness (pulse wave velocity (PWV), cardio-ankle vascular index (CAVI), ankle brachial index (ABI), aortic augmentation index (AI), central systolic and pulse aortic pressure, peripheral blood pressure (BP), estimated glomerular filtration rate (GFR) were assessed.) Results. The patients with ACS without ST elevation combined with 2-3A stages of CKD and AH had a significantly higher cPAP, AI, PWV, and CAVI than the patients of the 2nd group. During 3 months of complex therapy with perindopril, a decrease in PWV, cSAP, cPAP, AI was observed. There were no significant differences in the effects of perindopril and losartan on peripheral and central blood pressure, on renal function, on arterial stiffness parameters. Conclusion. Patients with AH and CKD stage 2-3A have more pronounced arterial stiffness compared to similar patients with normal GFR. Antihypertensive therapy with perindopril and losartan allows to reach target levels of peripheral BP, significantly reduce central aortic pressure and improve elastic properties of the arterial vascular wall.","PeriodicalId":24060,"journal":{"name":"Курский научно-практический вестник «Человек и его здоровье»","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76389166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of polysaccharides of common raspberry shoots and their sorption activity 普通覆盆子芽多糖及其吸附活性的研究
D. K. Gulyaev, V. D. Belonogova, I. P. Rudakova, I. V. Korotkov
A comparative study of the water-soluble polysaccharide complex and pectin substances of first and second year shoots of common raspberry. Objective - comparative study and sorption activity of polysaccharides of common raspberry shoots. Materials and methods. The samples for the research were collected in a dark coniferous forest on the territory of the Ilyinsky district of Perm Region. The content of polysaccharide fractions was determined by the modified Dreywood anthrone- sulfurous method. A water-soluble polysaccharide complex and pectin substances were sequentially obtained from different parts of the shoots. The sorption activity was determined by the ability of the substances to bind methylene blue, which is a marker for most medical sorbents. The acute toxicity of the obtained polysaccharide fractions was examined according to Prozorovsky V.V. Results. The shoots of the first and second year of common raspberry accumulate more pectin substances than water-soluble polysaccharides. Leaves of raspberry contain more polysaccharides compared to leafless parts. As a result of acute toxicity study, it was found that all studied substances can be classified as low-toxic (LD50>5,000 mg/kg). It was found that water-soluble polysaccharide complex obtained from leafless parts of the shoot of the first and second year shows sorption activity reliably higher than that of the reference preparation (Polyphepan). Sorption activity of pectin substances obtained from leaves of the first and second year shoots also exceeds that of the reference preparation. The highest sorption activity is shown by pectin substances of the second year, and the lowest sorption activity by pectin substances of leafless raspberry shoots. Conclusion. The obtained substances are promising for creating modern sorbents based on polysaccharide fractions of the first and second year shoots of common raspberry. Taking into account the simplicity in harvesting and high sorption activity of polysaccharides of the leafless part of the raspberry shoot, not only leaves but also leafless parts of the shoot should be harvested.
普通覆盆子一年生苗水溶性多糖复合物和果胶物质的比较研究。目的:比较研究普通覆盆子芽多糖的吸附活性。材料和方法。研究样本是在彼尔姆地区伊利因斯基地区的一片黑暗针叶林中收集的。采用改性蒽酮-硫法测定多糖组分的含量。从芽的不同部位依次得到水溶性多糖复合物和果胶物质。吸附活性是由物质结合亚甲基蓝的能力决定的,这是大多数医用吸附剂的标志。根据Prozorovsky V.V.结果检测所得多糖组分的急性毒性。普通覆盆子一、二年幼芽积累的果胶物质多于水溶性多糖。树莓的叶子比无叶的部分含有更多的多糖。急性毒性研究发现,所有研究物质均可归类为低毒(LD50> 5000 mg/kg)。结果表明,从一、二年茎部无叶部分提取的水溶性多糖复合物的吸附活性明显高于参比制剂(多聚苯乙烯)。一、二年嫩枝叶片对果胶物质的吸附活性也高于对照制剂。第二年果胶物质的吸附活性最高,无叶树莓新梢果胶物质的吸附活性最低。结论。所获得的物质有望以普通覆盆子一年生芽和第二年芽的多糖组分为基础制备现代吸附剂。考虑到覆盆子嫩枝的无叶部分采收简单,对多糖的吸附活性高,不仅要采收叶片,而且要采收嫩枝的无叶部分。
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引用次数: 0
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Курский научно-практический вестник «Человек и его здоровье»
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