Analytica Chimica Acta最新文献

{"title":"Enhanced microdialysis based on hydrophobic deep eutectic solvents for sampling of eugenol in Glyptocidaris crenularis","authors":"Jiaze Yan ,&nbsp;Chao Jiang ,&nbsp;Jiqi Zheng ,&nbsp;Ming Guo","doi":"10.1016/j.aca.2025.343774","DOIUrl":"10.1016/j.aca.2025.343774","url":null,"abstract":"<div><h3>Background</h3><div>Microdialysis is an in vivo technique for dynamically analyzing biochemical components in tissues and fluids. Traditional microdialysis systems are primarily designed for low molecular weight polar compounds, resulting in lower recoveries for hydrophobic compounds. This study aimed to develop a greener, cost-effective, and enhanced microdialysis method for recovering eugenol, isoeugenol, and methyl isoeugenol, utilizing hydrophobic deep eutectic solvents as the perfusate, with the method's feasibility verified through in vivo experiments.</div></div><div><h3>Results</h3><div>Among the 19 types of deep eutectic solvents evaluated, thymol-levulinic acid was identified as the most suitable for eugenol compounds based on liquid-liquid microextraction and microdialysis experiments, showing an in vitro microdialysis recovery approximately 100 times higher than that of water. The optimization of microdialysis parameters was conducted, including molar ratio of HBA:HBD, temperature, flow rate, and semi-permeable membrane length. In the in vivo microdialysis experiments, the temporal concentration of eugenol, which was used as an anesthetic in Glyptocidaris crenularis, was detected by GC-MS/MS and calibrated using ex vivo recovery. When the concentration of eugenol in artificial seawater was maintained at 100 μg mL⁻¹, the eugenol levels in the coelomic fluid of <em>Glyptocidaris crenularis</em> rose from 0 to 6.89 ± 0.38 μg mL⁻¹ within 60 min, then stabilized in next 80 min.</div></div><div><h3>Significance</h3><div>The findings demonstrate that deep eutectic solvents enhanced microdialysis provides high recoveries and enables real-time monitoring of drug concentration changes in biological systems, making this method a valuable tool for pharmacokinetic studies and environmental monitoring.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343774"},"PeriodicalIF":5.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An information processing triple input fluorescent probe for melanoma cancer","authors":"Imran Verirsen ,&nbsp;Nezahat Gokce Ozsamur ,&nbsp;Emin Sahin ,&nbsp;Sundus Erbas-Cakmak","doi":"10.1016/j.aca.2025.343769","DOIUrl":"10.1016/j.aca.2025.343769","url":null,"abstract":"<div><h3>Background</h3><div>Multi-analyte responsive fluorescent sensors are promising tools for selective imaging of malignant tissues. Glutathione tripeptide is a common cancer biomarker. Tyrosinase enzyme is involved in melanogenesis and neuroactive dopamine synthesis. Activity/level of this enzyme is significantly altered in various diseases including melanoma and neurological diseases. Molecular tools capable of sensing different cellular states are yet to be developed. In the research presented here, a novel reconfigurable pyridinium functionalized distyryl-BODIPY <strong>P2</strong> is developed as tyrosinase sensor with the synergistic effect of glutathione and carboxylesterase to discriminate different pathological cellular states.</div></div><div><h3>Results</h3><div>Acetyl-masked tyrosinase responsive 3-hydroxybenzyl substrate analogue is attached to the sensor. Following the ester hydrolysis by carboxylesterase, tyrosinase mediated oxidation to catechol followed by spontaneous 1,6-elimination generates pyridine BODIPY <strong>P1</strong>, resulting in 81 nm hypsochromic shift in aqueous solution compared to parent probe <strong>P2</strong>. Glutathione further enhances the response by removing acetyl group and/or reducing the quinone by-product back to cleavable quinol. A molecular AND logic gate can be constructed with enzymes and GSH, enabling multi-analyte melanoma sensing. Setting the fluorescence output threshold, distinct phenotypes can be diagnosed i.e. drug-resistant melanoma. Tyrosinase expressing B16–F10 melanoma cells display a significantly increased fluorescence when incubated with <strong>P2</strong> compared to breast cancer cells. When inhibitor of any of the inputs is used, fluorescence intensity is significantly reduced, proving the synergistic effect of all disease parameters.</div></div><div><h3>Significance</h3><div>With versatile chemistry and sufficient solubility in aqueous media, this structure provides the first triple input Near-IR fluorescent sensor for melanoma with the potential of discriminating different pathological status. Modular structure can provide a common scaffold for information processing molecular sensors for hydrolytic/oxidoreductive enzymes and/or disease associated analytes.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343769"},"PeriodicalIF":5.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COS-DeformDeep: Adaptive 2T2D spectral feature extraction method for improving the component identification performance in mixtures based on handheld Raman technology","authors":"Xin Zhao ,&nbsp;Ziyan Zhao ,&nbsp;Qibing Zhu ,&nbsp;Min Huang ,&nbsp;Xinnian Guo","doi":"10.1016/j.aca.2025.343773","DOIUrl":"10.1016/j.aca.2025.343773","url":null,"abstract":"<div><h3>Background</h3><div>Raman spectroscopy is extensively utilized for the analysis of mixture components. Handheld Raman spectrometers, characterized by their compactness and portability, can rapidly acquire on-site spectral data without the need for intricate pretreatment or bulky instrumentation. In comparison to traditional laboratory-grade spectrometers, handheld devices offer distinct advantages. Nevertheless, although the unique spectral fingerprints of different substances facilitate identification, accurately quantifying and analyzing each component in complex mixtures remains a significant challenge.</div></div><div><h3>Results</h3><div>Therefore, a novel method called COS-DeformDeep is proposed to enhance and extract spectral features in handheld Raman mixture component identification. Firstly, synchronous two-trace two-dimensional correlation spectroscopy (2T2D-COS) is performed on pure components and mixture samples to highlight weak signals in overlapped peaks. Subsequently, deformable convolutions (DCNs) enhance the adaptability of deep learning models towards geometric deformation in the correlation peak region, thereby improving the capability of spectral feature extraction in 2T2D-COS. The proposed method was verified on three mixture datasets. Meanwhile, three substances, Ethanol, Diacetone alcohol, and Histidine, were chosen as the identified components with a volume-weight ratio ranging from 2 % to 20 %. The COS-DeformDeep model achieves the best performance with an average accuracy, precision, recall, and F1 score of 94.97 %, 98.45 %, 92.44 %, and 95.06 % respectively.</div></div><div><h3>Significance</h3><div>The proposed COS-DeformDeep is a highly efficient method for extracting features from weak spectral signals. By effectively capturing and analyzing the subtle variations in signals, it significantly enhances the recognition accuracy of specific components at low concentrations in mixtures. Moreover, its simplicity and suitability for handheld devices make it accessible to a wide range of users.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343773"},"PeriodicalIF":5.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solution-processable all-solid-state chloride-selective electrode: Enhanced sensitivity from anion dopant exchange","authors":"Shi Hoe Ng ,&nbsp;Georgina E.K.K. Seah ,&nbsp;Dorsasadat Safanama,&nbsp;Shermin S. Goh","doi":"10.1016/j.aca.2025.343772","DOIUrl":"10.1016/j.aca.2025.343772","url":null,"abstract":"<div><div>Ion-selective electrodes (ISEs) are widely used in many industries, with recent research focusing on their miniaturization by replacing the liquid filling solutions with solid-contacts. Solution-processing is the preferred method for preparing solid-contact ISEs (SC-ISEs) due to its ease and scalability. However, while there are many solution-processable cationic SC-ISEs, this remains a challenge for anionic SC-ISEs due to poorer compatibility with the solid-contacts. Many anionic SC-ISEs are still prepared by complex techniques, such as electropolymerisation of the solid-contact. Thus, strategies for solution-processable solid-contacts which can interface well with anionic ion-selective membrane (ISMs) are required. Here, we report the fabrication of a fully-solution-processable chloride (<em>Cl</em>⁻) SC-ISE by anion exchange of poly(3,4-ethylenedioxythiophene)-polyethylene glycol (PEDOT-PEG) solid-contact before drop-casting the ISM. Significant improvement in sensitivity was observed after PEDOT-PEG anion exchange, with the optimal SC-ISE exhibiting near-Nernstian response (−53.3 ± 0.5 mV/decade, versus −33.4 ± 1.8 mV/decade for the unexchanged SC-ISE) across a wide dynamic range (0.05 M–6.03 μM). Our SC-ISE also exhibited excellent selectivity against phosphate (H₂PO₄⁻), bicarbonate (HCO₃⁻) and acetate (CH₃CO₂⁻) and could be utilized with minimal conditioning time and for prolonged usage. Finally, given the importance of <em>Cl</em>⁻ sensing in healthcare, we also demonstrated the potential of our <em>Cl</em>^– SC-ISE in sensing multiple synthetic biological samples such as sweat, urine and blood, and real human sweat (forearm samples). This work not only demonstrates the versatility of our anion exchange protocol, but also furthers the understanding of the different enhancement mechanisms – sensitivity or selectivity – depending on whether an ionophore was present in the ISM. We showed that regardless of the mechanism, our simple and efficient protocol could mitigate the issue of the original underperformance and can thus be readily extended to the scalable preparation of multiple types of anion-selective SC-ISEs.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343772"},"PeriodicalIF":5.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation and characterization of the various stereoisomers of a dinuclear tricarbonylrhenium(I) complex using a theoretical and experimental approach","authors":"Stéphen Le Garrec ,&nbsp;Isabelle Fabing ,&nbsp;Caroline Toppan ,&nbsp;Pierre Lavedan ,&nbsp;Mariusz Wolff ,&nbsp;Eric Benoist ,&nbsp;Suzanne Fery-Forgues ,&nbsp;Florence Bedos-Belval","doi":"10.1016/j.aca.2025.343749","DOIUrl":"10.1016/j.aca.2025.343749","url":null,"abstract":"<div><h3>Background</h3><div>The development of robust chiral transition metal complexes is of paramount importance for advanced asymmetric catalysis, diagnostic and therapy, as well as for the emerging field of solid-state luminescent materials. Tricarbonylrhenium(I) complexes are intrinsically chiral, and their association as dinuclear molecules introduces additional layers of diastereoisomerism and enantiomerism, enhancing their versatility for potential applications. Up to now, separation of dinuclear complexes has made it possible to isolate diasteroisomers or enantiomers bearing a second chiral center other than rhenium. However, binuclear complexes carrying only double octahedral chirality have not been isolated in enantiopure form so far.</div></div><div><h3>Results</h3><div>In the present work, a dinuclear complex featuring two bidentate ligands, specifically two 3-(2-pyridyl)-1,2,4-triazole (pyta) ligands bearing C8-alkyl chain, merged via a phenyl linker, was considered. DFT calculations was first used to predict the existence of three distinct isomers, which differ by the position of the ancillary ligands with respect to the organic ligand. Subsequently, the three stereoisomers were successfully isolated using chiral HPLC. Their absolute configuration, <em>i.e.</em> (C_Re,C_Re), (A_Re,A_Re) or <em>meso</em> (C_Re,A _Re), was determined by circular dichroism. For each stereoisomer, evidence was given for a mixture of two rotamers (<em>syn</em> and <em>anti</em>), differing by the relative orientation of the C8-alkyl chain. The structure of all chiral species was perfectly assigned by <span>NMR</span> TOCSY and NOESY experiments, circular dichroism and supported by DFT calculations.</div></div><div><h3>Significance</h3><div>This work marks the first successful separation and complete characterization of enantiomeric species of a binuclear tricarbonylrhenium complex in which chirality arises solely from the two metal centers connected by a linker. This achievement opens up new possibilities of applications where precise control of chirality is crucial. It potentially paves the way to a better use of other transition metal complexes, in these fields</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343749"},"PeriodicalIF":5.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cu2+-triggered turn-on fluorescence non-enzymatic probe based on covalent organic framework for the detection of methyl parathion","authors":"Zhangchi Xiao ,&nbsp;Yong Li ,&nbsp;Yulun Nie ,&nbsp;Liqiang Lu ,&nbsp;Chao Yang","doi":"10.1016/j.aca.2025.343775","DOIUrl":"10.1016/j.aca.2025.343775","url":null,"abstract":"<div><h3>Background</h3><div>Methyl parathion, a potent organophosphorus insecticide, is extensively employed in agriculture and animal husbandry, leading to significant environmental contamination with pesticide residues, posing a grave threat to human health. This compound irreversibly inhibits acetylcholinesterase (AChE) in the human nervous system, resulting in the accumulation of acetylcholine (ACh), which is detrimental. Various enzyme activity-based assays have been explored due to its pathogenic mechanism, yet these methods are fraught with limitations. Thus, the development of a highly selective, sensitive, rapid, and effective method for detecting methyl parathion residues is crucial.</div></div><div><h3>Result</h3><div>In this study, we introduce a novel, non-enzymatic fluorescent probe for methyl parathion detection. This probe is designed to specifically trigger the fluorescence signal of TAPB-DMTA-COF through the interaction of copper ions with the imine moiety within the TAPB-DMTA-COF structure. The detection of methyl parathion in aqueous environments is facilitated by the Inner filter effect. Compared to previously reported enzyme-catalyzed reaction probes, this probe exhibits a faster reaction time, is not influenced by enzyme activity, and demonstrates high specificity and sensitivity. The probe exhibits a good linear response in the concentration range of 0.56–5.46 μM, with a detection limit of 30.698 nM. Furthermore, the probe yielded satisfactory recoveries of methyl parathion (93.47 %–99.5 %) in different real water samples through spiking recovery experiments.</div></div><div><h3>Significance</h3><div>The fluorescent probe based on Cu²⁺/TAPB-DMTA-COF realizes the fluorescence detection of methyl parathion. The establishment of this simple, efficient, and rapid detection platform offers a new approach for the detection of pesticide residues in aquatic environments. The introduction of metal ions, along with the construction of COF materials and the use of fluorescence signal turn-on, provides a rational design strategy for such detection methods.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343775"},"PeriodicalIF":5.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of electrochemical sensing in droplet systems: Droplet and digital microfluidics","authors":"Kathy Ly ,&nbsp;Aaliya Pathan ,&nbsp;Darius G. Rackus","doi":"10.1016/j.aca.2025.343744","DOIUrl":"10.1016/j.aca.2025.343744","url":null,"abstract":"<div><h3>Background</h3><div>Microfluidic technologies based on droplets provide discrete volumes within which chemical and/or biological processes can take place. Two major platforms in this space include droplet microfluidics (emulsions within channels) and digital microfluidics (discrete droplet manipulation by electric fields). The integration of electrochemical sensing with both microfluidic platforms offers advantages in miniaturization and portability, as sensors can be integrated directly within the microfluidic devices and instrumentation is relatively compact.</div></div><div><h3>Results</h3><div>This review provides background on droplet and digital microfluidic technologies and electrochemical sensing before moving to methods and applications. A discussion of the various strategies to integrate sensing electrodes with both droplet and digital microfluidics and the merits of each method are included. A review of the many different applications of these integrated systems is provided.</div></div><div><h3>Significance and novelty</h3><div>To date, there are no reviews that solely focus on the integration of electrochemical sensing with droplet and digital microfluidics. There are many advantages to combining electrochemical sensing with these platforms, especially for applications where portability or small form factors are paramount. While early reports on integrating electrochemical sensing with droplet and digital microfluidics are more than a decade old, the field is still relatively nascent, offering opportunity for many applications.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1347 ","pages":"Article 343744"},"PeriodicalIF":5.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of defect-rich bimetallic MOF loaded on N, S-codoped MXene QDs/rGO for electrochemical detection of catechol","authors":"Ying Wang ,&nbsp;Xinming Wang ,&nbsp;Mingyue Chu ,&nbsp;Jianjiao Xin ,&nbsp;Yikun Liu ,&nbsp;Haijun Pang ,&nbsp;Guixin Yang ,&nbsp;Huiyuan Ma","doi":"10.1016/j.aca.2025.343770","DOIUrl":"10.1016/j.aca.2025.343770","url":null,"abstract":"<div><h3>Background</h3><div>Catechol (CC) is widely used in industrial synthesis but poses significant environmental and health risks due to its toxicity and low degradability. Developing sensitive and stable electrochemical sensors for CC detection is critical for effective environmental monitoring. This study presents a composite sensor based on N,S-MXene quantum dots (N,S-MQD) modified reduced graphene oxide (rGO) to anchor a defective bimetallic organic framework (D-FeCu-MOF) for rapid CC determination in water samples.</div></div><div><h3>Results</h3><div>The D-FeCu-MOF provides reversible redox properties, Lewis basic sites for analyte interaction, and excellent electron transfer ability with reduced resistance compared to FeCu-MOF (11413–7794 Ω), attributed to the presence of bimetallic sources, functional groups, and abundant defects. The N,S-MQD@rGO matrix possesses high dispersiveness and porosity, large surface area, abundant active sites and high conductivity (69.18 Ω) along with good water solubility. As a result, the D-FeCu-MOF/N,S-MQD@rGO sensor shows superior sensing performance for CC detection with wide linear ranges of 0.004–520 μM and low detection limit of 0.0014 μM.</div></div><div><h3>Significance</h3><div>The sensor shows great selectivity in the presence of potential interferents and shows promise for practical applications. It also delivers satisfactory recoveries (98.23–102.67 %) in real sample tests, highlighting its potential for environmental monitoring. This work offers new insights for the developing high-performance CC electrochemical sensor.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343770"},"PeriodicalIF":5.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of solvophobic interactions on the high-performance liquid chromatography enantioseparation of planar chiral 1,2-ferrocene derivatives on amylose tris(3,5-dimethylphenylcarbamate)","authors":"Francesca Romana Mammone ,&nbsp;Alexander Voigt ,&nbsp;Aylin Nagel ,&nbsp;Heinrich Lang ,&nbsp;Roberto Cirilli","doi":"10.1016/j.aca.2025.343771","DOIUrl":"10.1016/j.aca.2025.343771","url":null,"abstract":"<div><h3>Background</h3><div>Planar chiral ferrocenes are well-established metallocenes that have attracted considerable attention for several decades due to their potential applications in synthesis, catalysis, materials science and medicinal chemistry. The planar stereogenicity of these compounds occurs when the symmetry plane of a single planar ring is broken by the introduction of two or more different substituents. Recently, the range of applications of planar chiral ferrocenes has been further extended by using them as model systems to investigate the enantioselective properties of inherently chiral materials incorporated into electrochemical devices and polysaccharide-based chiral stationary phases used for enantioselective HPLC.</div></div><div><h3>Results</h3><div>This study aimed to evaluate planar chiral ferrocenes as probe molecules for the investigation of the enantiorecognition mechanism operating on the polysaccharide-based Chiralpak AD-3 chiral stationary phase containing amylose-tris(3,5-dimethylphenylcarbamate) as selector. A set of six planar chiral 1,2-ferrocene derivatives with a phosphine or phosphine oxide moiety at position 1 and π conjugated systems at position 2 were designed for this purpose. The chromatographic performance of the Chiralpak AD-3 chiral stationary phase in achieving enantioseparation was evaluated using pure ethanol and 2-propanol as mobile phases, with temperature variation as a variable. The use of 2-propanol instead of ethanol results in optimal conditions for the entropy-driven separation of the first eluted (<em>Sp</em>) enantiomer and the second eluted (<em>Rp</em>) enantiomer of phosphine oxide ferrocenes. An unusually high chiral discrimination was observed for the ferrocene phosphine oxide bearing an (<em>E</em>)-buta-1,3-dienyl group at the 2-position.</div></div><div><h3>Significance</h3><div>A meticulous and comprehensive chromatographic investigation has revealed that pronounced chiral discrimination is driven by solvophobic interactions, which are typically underestimated in studies of this nature, particularly those involving the π-conjugated apolar fragments of the ferrocene. In principle, the modeling of the unconventional chromatographic data obtained in this study could be used to assess the predictive capability of the enantiorecognition process of <em>in silico</em> models of the amylose-tris(3,5-dimethylphenylcarbamate)-based chiral stationary phase.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343771"},"PeriodicalIF":5.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic structural color microspheres for the multiplex detection of acute kidney injury biomarkers","authors":"Haiwen Su ,&nbsp;Haoyu Ren ,&nbsp;Zhiyan Xuan ,&nbsp;Xiayidan Maimaitikelimu ,&nbsp;Yile Fang ,&nbsp;Hengjin Wang ,&nbsp;Huan Wang","doi":"10.1016/j.aca.2025.343767","DOIUrl":"10.1016/j.aca.2025.343767","url":null,"abstract":"<div><h3>Background</h3><div>Acute kidney injury (AKI) is a frequent acute condition that features sharp loss of kidney functions and often leads to severe situations such as end-stage renal disease and even death. The incidence and mortality of AKI in hospitalized patients are high worldwide, and one of the reasons for this poor prognosis is the inability to diagnose AKI promptly. The sensitive and specific assay of biomarkers is considered a promising method for early diagnosis of AKI.</div></div><div><h3>Results</h3><div>We designed a magnetic-responsive structural colored inverse opal hydrogel microspheres (IOHMs) for the multiplex detection of cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL), which are two early biomarkers of AKI. The microsphere possessed structural colors for encoding and directional motion ability for improved detection sensitivity and separation efficiency, showing the detection ranges of CysC and NGAL in 10–5000 ng/mL and 10–1000 ng/mL, respectively.</div></div><div><h3>Significance</h3><div>The method's accuracy and reliability were consistent with commonly used enzyme-linked immunosorbent assay methods. Therefore, these magnetic IOHMs have a promising application for early AKI diagnosis.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1346 ","pages":"Article 343767"},"PeriodicalIF":5.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}