Pub Date : 2026-03-13DOI: 10.1016/j.aca.2026.345389
Madison L. Williams, Aethena Fitzgerald, David Alonso, Joe Binkley, John Hayes, Michael Stebler, Emanuela Gionfriddo
{"title":"Comparison of Solid Phase Microextraction Coatings for Headspace Extraction of Volatile Perfluoroalkyl Substances Using One-Dimensional and Comprehensive Two-Dimensional Gas Chromatography","authors":"Madison L. Williams, Aethena Fitzgerald, David Alonso, Joe Binkley, John Hayes, Michael Stebler, Emanuela Gionfriddo","doi":"10.1016/j.aca.2026.345389","DOIUrl":"https://doi.org/10.1016/j.aca.2026.345389","url":null,"abstract":"","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"2 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.aca.2026.345392
Andrea Cerrato, Enrico Taglioni, Chiara Cavaliere, Aldo Laganà, Elena Lucà, Carmela Maria Montone, Anna Laura Capriotti
{"title":"Azetidination-based photocycloaddition enables regioisomer-resolved annotation of cholesteryl esters by negative-ion-mode LC-MS/MS","authors":"Andrea Cerrato, Enrico Taglioni, Chiara Cavaliere, Aldo Laganà, Elena Lucà, Carmela Maria Montone, Anna Laura Capriotti","doi":"10.1016/j.aca.2026.345392","DOIUrl":"https://doi.org/10.1016/j.aca.2026.345392","url":null,"abstract":"","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"9 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimized Cleanup Strategy for the Determination of Bisphenols in Human Serum with Na86(AlO2)86(SiO2)106 as Sorbents: Molecular Insights and Critical Factor Evaluation","authors":"Jing Jin, Cuicui Guo, He Zhang, Tian Tian, Bairong Fu, Longxing Wang, Dongqin Tan, Jiajia Yang, Ningbo Geng, Jiping Chen","doi":"10.1016/j.aca.2026.345396","DOIUrl":"https://doi.org/10.1016/j.aca.2026.345396","url":null,"abstract":"","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1016/j.aca.2026.345373
Donghyun Ryoo, Seong-Soo Lee, Emanuela Gionfriddo, Jared L. Anderson
Background
The production of fluorinated organic compounds in the manufacturing, semiconductor, and pharmaceutical industries has increased exponentially over the past decade. This rapid growth has created an urgent need for efficient chromatographic platforms capable of selectively separating these compounds from complex mixtures, not only to support industrial quality control and waste management practices, but also to enable reliable environmental monitoring of volatile fluorinated contaminants. Conventional GC stationary phases lack the fluorophilic interactions needed for highly fluorinated analytes. Consequently, there is a clear demand for specialized stationary phases designed to improve chromatographic retention and selectivity for these compounds.
Results
Three stationary phases composed of fluorinated ionic liquids (ILs) with varied extent of fluorination were prepared to study fluorophilic interactions with fluorinated/non-fluorinated probe molecules by gas chromatography (GC). IL stationary phases featuring linear and branched perfluoroalkyl moieties, as well as a branched alkyl moiety, were systematically investigated. Chromatographic performance was examined using fluorinated compounds and their hydrocarbon analogues, including CF3-substituted aromatics, aliphatic alcohols, fluorotelomer alcohols (FTOHs), and perfluoroalkenes. Measurements on 5 m and 20 m columns revealed that the IL possessing branched alkyl provided stronger dispersive and hydrogen bonding interactions toward non-fluorinated aromatic and long-chain alcohols, whereas the fluorinated ILs enhanced retention of highly fluorinated FTOHs and perfluorodecene. Comprehensive two-dimensional GC (GC×GC), using a nonpolar primary column coupled with secondary columns featuring cross-bonded poly(trifluoropropylmethyl siloxane) (Rtx-200ms), the branched fluorinated IL, or the branched non-fluorinated IL, highlighted complementary selectivity with the branched fluorinated IL providing the strongest interactions with fluorinated analytes.
Significance
These results demonstrate that fluorinated IL stationary phases are promising alternatives to conventional polysiloxane stationary phases for improving the separation of per- and polyfluoroalkyl substances and related fluorinated compounds. By correlating IL structure with fluorophilic interactions, this work establishes design principles for GC stationary phases that enable enhanced selectivity for highly fluorinated analytes while maintaining complementary interactions with non-fluorinated compounds.
{"title":"Fluorinated ionic liquids as gas chromatographic stationary phases for the separation of volatile per- and polyfluoroalkyl substances","authors":"Donghyun Ryoo, Seong-Soo Lee, Emanuela Gionfriddo, Jared L. Anderson","doi":"10.1016/j.aca.2026.345373","DOIUrl":"https://doi.org/10.1016/j.aca.2026.345373","url":null,"abstract":"<h3>Background</h3>The production of fluorinated organic compounds in the manufacturing, semiconductor, and pharmaceutical industries has increased exponentially over the past decade. This rapid growth has created an urgent need for efficient chromatographic platforms capable of selectively separating these compounds from complex mixtures, not only to support industrial quality control and waste management practices, but also to enable reliable environmental monitoring of volatile fluorinated contaminants. Conventional GC stationary phases lack the fluorophilic interactions needed for highly fluorinated analytes. Consequently, there is a clear demand for specialized stationary phases designed to improve chromatographic retention and selectivity for these compounds.<h3>Results</h3>Three stationary phases composed of fluorinated ionic liquids (ILs) with varied extent of fluorination were prepared to study fluorophilic interactions with fluorinated/non-fluorinated probe molecules by gas chromatography (GC). IL stationary phases featuring linear and branched perfluoroalkyl moieties, as well as a branched alkyl moiety, were systematically investigated. Chromatographic performance was examined using fluorinated compounds and their hydrocarbon analogues, including CF<sub>3</sub>-substituted aromatics, aliphatic alcohols, fluorotelomer alcohols (FTOHs), and perfluoroalkenes. Measurements on 5 m and 20 m columns revealed that the IL possessing branched alkyl provided stronger dispersive and hydrogen bonding interactions toward non-fluorinated aromatic and long-chain alcohols, whereas the fluorinated ILs enhanced retention of highly fluorinated FTOHs and perfluorodecene. Comprehensive two-dimensional GC (GC×GC), using a nonpolar primary column coupled with secondary columns featuring cross-bonded poly(trifluoropropylmethyl siloxane) (Rtx-200ms), the branched fluorinated IL, or the branched non-fluorinated IL, highlighted complementary selectivity with the branched fluorinated IL providing the strongest interactions with fluorinated analytes.<h3>Significance</h3>These results demonstrate that fluorinated IL stationary phases are promising alternatives to conventional polysiloxane stationary phases for improving the separation of per- and polyfluoroalkyl substances and related fluorinated compounds. By correlating IL structure with fluorophilic interactions, this work establishes design principles for GC stationary phases that enable enhanced selectivity for highly fluorinated analytes while maintaining complementary interactions with non-fluorinated compounds.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"47 1","pages":"345373"},"PeriodicalIF":6.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1016/j.aca.2026.345375
Magdalena Matczuk, Joanna Zajda, Andrei R. Timerbaev, Lena Ruzik
Magnetoliposomes are steadily moving to the forefront of nanomedomics as an advanced class of liposomes and lipid-based carriers. In recent years, considerable progress has been made in synthesizing and characterizing different magnetoliposomic structures, resulting in several attractive drug formulations with multimodal therapeutic and diagnostic functions. However, effective clinical translation remains difficult due to a lack of fundamental knowledge about the biological response to these nanohybrids. In this brief review, we explain our viewpoint on how this challenge can be addressed by using methods and approaches of analytical chemistry. Special focus is placed on the implementation and critical assessment of advanced analytical methodologies to investigate the magnetoliposome materials concerning their stability, drug loading efficiency, cellular internalization and processing (including external stimuli-responsive cargo release), biodistribution, etc.
{"title":"Role of analytical chemistry in the development of magnetoliposomes: Current and emerging techniques","authors":"Magdalena Matczuk, Joanna Zajda, Andrei R. Timerbaev, Lena Ruzik","doi":"10.1016/j.aca.2026.345375","DOIUrl":"https://doi.org/10.1016/j.aca.2026.345375","url":null,"abstract":"Magnetoliposomes are steadily moving to the forefront of nanomedomics as an advanced class of liposomes and lipid-based carriers. In recent years, considerable progress has been made in synthesizing and characterizing different magnetoliposomic structures, resulting in several attractive drug formulations with multimodal therapeutic and diagnostic functions. However, effective clinical translation remains difficult due to a lack of fundamental knowledge about the biological response to these nanohybrids. In this brief review, we explain our viewpoint on how this challenge can be addressed by using methods and approaches of analytical chemistry. Special focus is placed on the implementation and critical assessment of advanced analytical methodologies to investigate the magnetoliposome materials concerning their stability, drug loading efficiency, cellular internalization and processing (including external stimuli-responsive cargo release), biodistribution, etc.","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"33 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-08Epub Date: 2026-01-22DOI: 10.1016/j.aca.2026.345141
Xin Zhang , Guangxing Gu , Jiajin Weng , Chenyang Wang , Zixuan Ma , Xiaojun Tang , Yanchuan Zhao
Background
Chiral pesticides are increasingly important in agrochemicals, with enantiomers differing significantly in bioactivity, toxicity, and environmental impact. Rapid and robust methods for resolving these enantiomers in complex matrices are essential for regulatory monitoring and mechanistic studies.
Results
We developed a separation-free 19F NMR chemosensing platform using dual-stereocenter 19F-labeled Pd probes. The method enables direct enantiodifferentiation of N-heterocyclic pesticides, including complex cases like difenoconazole where all four stereoisomers are fully resolved in a single 19F spectrum. Quantitative enantiomeric excess (ee values) determination shows excellent linearity, with deviations from the true ee values of less than 2 %. The platform also resolves six pesticides simultaneously in a mixture and, in soil extracts, monitors in situ stereoselective degradation, revealing significant degradation bias between enantiomers.
Significance
Dual-stereocenter 19F NMR probes deliver a practical alternative to chiral chromatography for pesticide residue analysis, combining operational simplicity, matrix tolerance, multicomponent capability, and quantitative rigor. The method enables direct, separation-free readout of stereochemistry and kinetics in complex samples and reveals in situ enantioselective degradation pathways. These attributes provide actionable insight for precision application, environmental risk assessment, and regulatory surveillance of chiral agrochemicals.
{"title":"Separation-free enantiodiscrimination of chiral pesticides via dual-stereocenter 19F NMR probes for multicomponent and environmental analysis","authors":"Xin Zhang , Guangxing Gu , Jiajin Weng , Chenyang Wang , Zixuan Ma , Xiaojun Tang , Yanchuan Zhao","doi":"10.1016/j.aca.2026.345141","DOIUrl":"10.1016/j.aca.2026.345141","url":null,"abstract":"<div><h3>Background</h3><div>Chiral pesticides are increasingly important in agrochemicals, with enantiomers differing significantly in bioactivity, toxicity, and environmental impact. Rapid and robust methods for resolving these enantiomers in complex matrices are essential for regulatory monitoring and mechanistic studies.</div></div><div><h3>Results</h3><div>We developed a separation-free <sup>19</sup>F NMR chemosensing platform using dual-stereocenter <sup>19</sup>F-labeled Pd probes. The method enables direct enantiodifferentiation of N-heterocyclic pesticides, including complex cases like difenoconazole where all four stereoisomers are fully resolved in a single <sup>19</sup>F spectrum. Quantitative enantiomeric excess (ee values) determination shows excellent linearity, with deviations from the true ee values of less than 2 %. The platform also resolves six pesticides simultaneously in a mixture and, in soil extracts, monitors in situ stereoselective degradation, revealing significant degradation bias between enantiomers.</div></div><div><h3>Significance</h3><div>Dual-stereocenter <sup>19</sup>F NMR probes deliver a practical alternative to chiral chromatography for pesticide residue analysis, combining operational simplicity, matrix tolerance, multicomponent capability, and quantitative rigor. The method enables direct, separation-free readout of stereochemistry and kinetics in complex samples and reveals in situ enantioselective degradation pathways. These attributes provide actionable insight for precision application, environmental risk assessment, and regulatory surveillance of chiral agrochemicals.</div></div>","PeriodicalId":240,"journal":{"name":"Analytica Chimica Acta","volume":"1390 ","pages":"Article 345141"},"PeriodicalIF":6.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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