Pub Date : 2022-07-30DOI: 10.37311/ijpe.v2i2.15484
D. Fauziah, Elly Mulyani
Hypertension is a condition where an increase in systolic or diastolic blood pressure ≥ 140/90 mmHg. Success of hypertension therapy is influenced by several factors, one of which is compliance with taking hypertension medication. Adherence to take medication is very important to improve the effectiveness of treatment and prevent complications. Poor adherence to drug consumption is the most frequent cause of failure of antihypertensive therapy. Compliance can be used as a parameter of a patient's level of knowledge in carrying out instructions from medical personnel. The purpose of this study was to determine the relationship of knowledge of adherence to taking antihypertensive drugs for patients in the work area of the Lebong District Health Center in 2019. The research method used in this study is analytical research using a cross-sectional design which is a research plan of a study to study the dynamics of the correlation between the independent variable (knowledge) with the effect or dependent variable (the level of compliance taking antihypertensive medication) which is observed or collected data at once at the same time. From this study obtained the Odds Ratio (OR) = 3,781 (95% CI: 1,503-9,513) which means someone with less knowledge has a risk of 1.503 times for not compliant to take anti-hypertensive drugs than someone who has good knowledge. There is a significant relationship between knowledge with the level of adherence to take antihypertensive medication in the working area of the Lebong District Health Center.
{"title":"Hubungan Pengetahuan Terhadap Tingkat Kepatuhan Minum Obat Anti Hipertensi","authors":"D. Fauziah, Elly Mulyani","doi":"10.37311/ijpe.v2i2.15484","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.15484","url":null,"abstract":"Hypertension is a condition where an increase in systolic or diastolic blood pressure ≥ 140/90 mmHg. Success of hypertension therapy is influenced by several factors, one of which is compliance with taking hypertension medication. Adherence to take medication is very important to improve the effectiveness of treatment and prevent complications. Poor adherence to drug consumption is the most frequent cause of failure of antihypertensive therapy. Compliance can be used as a parameter of a patient's level of knowledge in carrying out instructions from medical personnel. The purpose of this study was to determine the relationship of knowledge of adherence to taking antihypertensive drugs for patients in the work area of the Lebong District Health Center in 2019. The research method used in this study is analytical research using a cross-sectional design which is a research plan of a study to study the dynamics of the correlation between the independent variable (knowledge) with the effect or dependent variable (the level of compliance taking antihypertensive medication) which is observed or collected data at once at the same time. From this study obtained the Odds Ratio (OR) = 3,781 (95% CI: 1,503-9,513) which means someone with less knowledge has a risk of 1.503 times for not compliant to take anti-hypertensive drugs than someone who has good knowledge. There is a significant relationship between knowledge with the level of adherence to take antihypertensive medication in the working area of the Lebong District Health Center.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127063662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.37311/ijpe.v2i2.13989
Nurchamidin Gobel
Patients are one indicator of the quality of services we provide and patient satisfaction is a capital to get more patients and to get loyal patients (faithful). Loyal patients will reuse the same health services if they need it again. Even loyal patients will invite others to use the same health service facility. The purpose of this study is to describe the level of patient satisfaction. This type of research uses a descriptive method with concurrent data collection. The data collected is in the form of result data (observations and questionnaires). Concurrent data is primary data obtained during direct observation and questionnaires during the research. This research was conducted from the second week of December 2020 until the end of February 2021. The data obtained is based on the answers from respondents to the questionnaire that has been tested for validity and reliability and then distributed. Furthermore, processed and analyzed and seen the percentage level of patient satisfaction which is presented in tabular form. Based on the data obtained from the respondents' answers, it can be concluded that the description of the level of patient satisfaction in the pharmacy installation of ZUS Hospital North Gorontalo is in the good category, with an average percentage of 81%. The criterion aspect of the question that received the most positive response from the respondents was that the service procedures at IFRSUD ZUS Gorontalo Utara were fast and did not bother the patient? (94%) and on the aspect of the criteria the question is that whether the officers are fair in providing services? (63%). Things that need to be done to improve aspects of questions that are still in the sufficient category are by improving the pharmaceutical service process as a whole, conducting supervision and awareness for all parties.
{"title":"Gambaran Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Rumah Sakit","authors":"Nurchamidin Gobel","doi":"10.37311/ijpe.v2i2.13989","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.13989","url":null,"abstract":"Patients are one indicator of the quality of services we provide and patient satisfaction is a capital to get more patients and to get loyal patients (faithful). Loyal patients will reuse the same health services if they need it again. Even loyal patients will invite others to use the same health service facility. The purpose of this study is to describe the level of patient satisfaction. This type of research uses a descriptive method with concurrent data collection. The data collected is in the form of result data (observations and questionnaires). Concurrent data is primary data obtained during direct observation and questionnaires during the research. This research was conducted from the second week of December 2020 until the end of February 2021. The data obtained is based on the answers from respondents to the questionnaire that has been tested for validity and reliability and then distributed. Furthermore, processed and analyzed and seen the percentage level of patient satisfaction which is presented in tabular form. Based on the data obtained from the respondents' answers, it can be concluded that the description of the level of patient satisfaction in the pharmacy installation of ZUS Hospital North Gorontalo is in the good category, with an average percentage of 81%. The criterion aspect of the question that received the most positive response from the respondents was that the service procedures at IFRSUD ZUS Gorontalo Utara were fast and did not bother the patient? (94%) and on the aspect of the criteria the question is that whether the officers are fair in providing services? (63%). Things that need to be done to improve aspects of questions that are still in the sufficient category are by improving the pharmaceutical service process as a whole, conducting supervision and awareness for all parties.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123874112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.37311/ijpe.v2i2.13532
Nur Ain Thomas, Robert Tungadi, Yuni Sarah Manoppo
God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.
{"title":"Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim","authors":"Nur Ain Thomas, Robert Tungadi, Yuni Sarah Manoppo","doi":"10.37311/ijpe.v2i2.13532","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.13532","url":null,"abstract":"God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124438914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.37311/ijpe.v2i2.14109
Puput Astreawati, Yulianis Yulianis, Medi Andriani
Improper or inefficient storage makes expired drugs undetected can cost pharmacies. Therefore, in the selection of a storage system, it must be selected and adapted to the existing conditions so that drug services can be carried out in an effective and efficient manner. The purpose of this study is to see the drug storage system based on storage standards at the Jambi City Pharmacy.This study uses a descriptive observational method by making observations (direct observations). Data collection is done by the checklist method. The population of this research is pharmacies in 8 districts of Jambi city. The sample of this research is pharmacies who are willing to give research permits, with a total of 1 pharmacy in 1 sub-district. This research was conducted from May 2021 to July 2021.The results of the research on the study of the implementation of the drug storage system at the Jambi City Pharmacy, namely facilities and infrastructure for drug storage with good criteria 6 pharmacies and very good 2 pharmacies, storage standards with very good criteria in all pharmacies, high alert drug storage with poor criteria in all pharmacies, storage of certain drugs/drug ingredients with very good criteria in all pharmaciesThe results of this study can be concluded that the drug storage system in Jambi City pharmacies has good criteria 6 pharmacies and 2 pharmacies are very good. Suggestions for pharmacies in Jambi City are to add special cabinet facilities to avoid medication errors.
{"title":"Studi Implementasi Sistem Penyimpanan Obat Di Apotek","authors":"Puput Astreawati, Yulianis Yulianis, Medi Andriani","doi":"10.37311/ijpe.v2i2.14109","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.14109","url":null,"abstract":"Improper or inefficient storage makes expired drugs undetected can cost pharmacies. Therefore, in the selection of a storage system, it must be selected and adapted to the existing conditions so that drug services can be carried out in an effective and efficient manner. The purpose of this study is to see the drug storage system based on storage standards at the Jambi City Pharmacy.This study uses a descriptive observational method by making observations (direct observations). Data collection is done by the checklist method. The population of this research is pharmacies in 8 districts of Jambi city. The sample of this research is pharmacies who are willing to give research permits, with a total of 1 pharmacy in 1 sub-district. This research was conducted from May 2021 to July 2021.The results of the research on the study of the implementation of the drug storage system at the Jambi City Pharmacy, namely facilities and infrastructure for drug storage with good criteria 6 pharmacies and very good 2 pharmacies, storage standards with very good criteria in all pharmacies, high alert drug storage with poor criteria in all pharmacies, storage of certain drugs/drug ingredients with very good criteria in all pharmaciesThe results of this study can be concluded that the drug storage system in Jambi City pharmacies has good criteria 6 pharmacies and 2 pharmacies are very good. Suggestions for pharmacies in Jambi City are to add special cabinet facilities to avoid medication errors.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123183297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.37311/ijpe.v2i2.13958
Ni Made Maharianingsih, I. K. Sudirta, Nita Suryaningsih
The development of cases of COVID-19 (coronavirus disease 2019) in the province Bali to increase until it ranks 10 th in Indonesia. This study aims to determine the characteristics of patients and the description of drug use for COVID-19 patients at Karangasem Hospital Bali for the period April 2020-Aril 2021. This study used a descriptive observational method with a cross-sectional design through a retrospective data search. The number of respondents as a sample was 200 patients with purposive sampling technique. The data collected is in the form of secondary data, which comes from medical records of COVID-19 patients at Karangasem Hospital. The results of the study showed that the most COVID-19 patients in Karangasem RSUD were from adults as many as 109 people (54.5%). Clinical symptoms experienced by all patients were fever with body temperature 38°C for more than 3 days and headache (100%). Patients who had comorbid as many as 196 people (98%) with pneumonia being the highest comorbid as many as 102 people (51%). The length of hospitalization for patients is generally 0-7 days by 69% (138 people). The highest patient status experienced moderate degree of symptoms by 89% (178 people) and severe 11% (22 people). The most drugs given to patients was vitamin C intravenously by 71% (142 people), while antiviral drugs in the form of oseltamivir (tamiflu) became the least by 1% (2 people). The characteristics of moderate-to-severe COVID-19 patients are dominated by male adult patients, have comorbidities (98%), clinical symptoms experienced by all patients are fever for more than 3 days and headache, with hospitalization for more than 3 days. The type of drug that is most often used is for antipyretic analgesics is paracetamol, the type of antibiotic is azithromycin, the type of antiviral is favipiravir, the type of corticosteroid is dexamethasone.
{"title":"Karakteristik Pasien dan Penggunaan Obat Pada Pasien Covid-19 Derajat Sedang Hingga Berat","authors":"Ni Made Maharianingsih, I. K. Sudirta, Nita Suryaningsih","doi":"10.37311/ijpe.v2i2.13958","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.13958","url":null,"abstract":"The development of cases of COVID-19 (coronavirus disease 2019) in the province Bali to increase until it ranks 10 th in Indonesia. This study aims to determine the characteristics of patients and the description of drug use for COVID-19 patients at Karangasem Hospital Bali for the period April 2020-Aril 2021. This study used a descriptive observational method with a cross-sectional design through a retrospective data search. The number of respondents as a sample was 200 patients with purposive sampling technique. The data collected is in the form of secondary data, which comes from medical records of COVID-19 patients at Karangasem Hospital. The results of the study showed that the most COVID-19 patients in Karangasem RSUD were from adults as many as 109 people (54.5%). Clinical symptoms experienced by all patients were fever with body temperature 38°C for more than 3 days and headache (100%). Patients who had comorbid as many as 196 people (98%) with pneumonia being the highest comorbid as many as 102 people (51%). The length of hospitalization for patients is generally 0-7 days by 69% (138 people). The highest patient status experienced moderate degree of symptoms by 89% (178 people) and severe 11% (22 people). The most drugs given to patients was vitamin C intravenously by 71% (142 people), while antiviral drugs in the form of oseltamivir (tamiflu) became the least by 1% (2 people). The characteristics of moderate-to-severe COVID-19 patients are dominated by male adult patients, have comorbidities (98%), clinical symptoms experienced by all patients are fever for more than 3 days and headache, with hospitalization for more than 3 days. The type of drug that is most often used is for antipyretic analgesics is paracetamol, the type of antibiotic is azithromycin, the type of antiviral is favipiravir, the type of corticosteroid is dexamethasone.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114476215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.37311/ijpe.v2i2.13333
Siti Alfanda Makmur, Madania Madania, Nur Rasdianah
Chronic Kidney Disease (CKD) is a condition in which there is a decrease in kidney function due to the presence of chronic and irreversible renal parenchyma. Patients with chronic disease often require a combination of several drugs. The administration of drugs combination is generally expected to have a beneficial effect. However, in some cases, drug interactions resulted in ineffective treatment and the emergence of unexpected events. This research aimed to determine drug interactions in patients with chronic kidney disease who are undergoing hemodialysis in the Inpatient Installation of Dr. M.M Dunda Limboto Hospital. This research was observational using a cross-sectional design and retrospective data collection. The sampling technique used was a purposive sampling technique with a total of 51 patient who met the inclusion criteria during the July-Desember 2020 period. Drug interaction data analysis was based on the Drug Interaction Checker and Drug Interaction Facts. The results showed that the most widely used drugs in patients with chronic kidney disease at Dr. M.M Dunda Limboto Hospital were anti-hypertensi drugs (17%), vitamins and minerals (13.30%), and gastrointestinal (11.32%). Drugs interactions with pharmacodynamic mechanisms were 31 cases (53.45%), pharmacokinetics were 21 cases (36.21%), and 6 cases were unknown (10.34%). The level of clinical significance in patients with chronic kidney disease was 75.86% moderate, 13.80% minor, and 10.34% major.
{"title":"Gambaran Interaksi Obat Pada Pasien Gagal Ginjal Kronik Dalam Proses Hemodialisis","authors":"Siti Alfanda Makmur, Madania Madania, Nur Rasdianah","doi":"10.37311/ijpe.v2i2.13333","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.13333","url":null,"abstract":"Chronic Kidney Disease (CKD) is a condition in which there is a decrease in kidney function due to the presence of chronic and irreversible renal parenchyma. Patients with chronic disease often require a combination of several drugs. The administration of drugs combination is generally expected to have a beneficial effect. However, in some cases, drug interactions resulted in ineffective treatment and the emergence of unexpected events. This research aimed to determine drug interactions in patients with chronic kidney disease who are undergoing hemodialysis in the Inpatient Installation of Dr. M.M Dunda Limboto Hospital. This research was observational using a cross-sectional design and retrospective data collection. The sampling technique used was a purposive sampling technique with a total of 51 patient who met the inclusion criteria during the July-Desember 2020 period. Drug interaction data analysis was based on the Drug Interaction Checker and Drug Interaction Facts. The results showed that the most widely used drugs in patients with chronic kidney disease at Dr. M.M Dunda Limboto Hospital were anti-hypertensi drugs (17%), vitamins and minerals (13.30%), and gastrointestinal (11.32%). Drugs interactions with pharmacodynamic mechanisms were 31 cases (53.45%), pharmacokinetics were 21 cases (36.21%), and 6 cases were unknown (10.34%). The level of clinical significance in patients with chronic kidney disease was 75.86% moderate, 13.80% minor, and 10.34% major.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125895966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-29DOI: 10.37311/ijpe.v2i2.11449
Teti sutriyati Tuloli, Nur Rasdianah, Maimun Datau
Off-label drugs can be interpreted as drugs that are used not in accordance with drug information, distribution permits and sales licenses from the Marketing Authorization (MA) related to indications, age, dosage, route of administration and contraindications. The use of off-label drugs in children occurs because of incomplete data on pharmacokinetics, pharmacodynamics and side effect of a drug. It is because clinical research in children is quite difficult and not in accordance with research ethics and morals, so it has the potential to cause errors in treatment and unwanted drug reactions. This study aims to describe the use of off-label drugs in hospitalized pediatric patients at RSUD of Dr. M.M Dunda Limboto, Gorontalo District, Gorontalo Province. This is an obsevational study using cross sectional design and retrospective data collection. The sampling technique applies a purposive sampling technique with a total of 155 patiens who meet the inclusion criteria during the January-June 2020 period. The finding shows that from 155 patient medical records, there are 172 (16,51%) off-label drug used with a total of 1042 drugs. The off-label drugs used in the indication category are 64,53%, the off-label drugs used in dose category are 17,44%, the off-label drugs used in age category are 14,53%, the off-label drugs used in route of administration category are 3,49% and the off-label drugs used in contraindictions category are not found. The are the most off-label drugs used in each category, including domperidone (off-label in indications and dose), rhinofed (off-label in age) and salbutamol (off-label in route of administration).
{"title":"Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap Di Rumah Sakit","authors":"Teti sutriyati Tuloli, Nur Rasdianah, Maimun Datau","doi":"10.37311/ijpe.v2i2.11449","DOIUrl":"https://doi.org/10.37311/ijpe.v2i2.11449","url":null,"abstract":"Off-label drugs can be interpreted as drugs that are used not in accordance with drug information, distribution permits and sales licenses from the Marketing Authorization (MA) related to indications, age, dosage, route of administration and contraindications. The use of off-label drugs in children occurs because of incomplete data on pharmacokinetics, pharmacodynamics and side effect of a drug. It is because clinical research in children is quite difficult and not in accordance with research ethics and morals, so it has the potential to cause errors in treatment and unwanted drug reactions. This study aims to describe the use of off-label drugs in hospitalized pediatric patients at RSUD of Dr. M.M Dunda Limboto, Gorontalo District, Gorontalo Province. This is an obsevational study using cross sectional design and retrospective data collection. The sampling technique applies a purposive sampling technique with a total of 155 patiens who meet the inclusion criteria during the January-June 2020 period. The finding shows that from 155 patient medical records, there are 172 (16,51%) off-label drug used with a total of 1042 drugs. The off-label drugs used in the indication category are 64,53%, the off-label drugs used in dose category are 17,44%, the off-label drugs used in age category are 14,53%, the off-label drugs used in route of administration category are 3,49% and the off-label drugs used in contraindictions category are not found. The are the most off-label drugs used in each category, including domperidone (off-label in indications and dose), rhinofed (off-label in age) and salbutamol (off-label in route of administration).","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127986519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-03DOI: 10.37311/ijpe.v2i1.11283
Linsih Umar, Hamsidar Hasan, Mahdalena Sy pakaya
One of the plants that has potential as medicine is kencur(Kaemoferia galanga L). Many studies have asserted that the rhizome of kencur is useful for bacterial infections, cough medicine, dysentery, cold, and stomachache. Therefore, the research aimed to identify the toxic effect of kencur leaf extract on artemia salina larvae applying the BSLT (Brine shrimp lethaly test) method. It employed three concentration treatments using 10 artemia salina larvae that died after 48 hours. Futher, it was calculated by LC50with probit analysis. The result of probit analysis revealed that the value of LC50from n-hexane extract was 96,13µg/mL, ethyl acetate extract was 98,22 µg/mL and methanol extract of kencur leaf was 156,06 µg/mL. The LC50 value of the extract was in the active category, with the value of LC50was lower than 1000 ppm.
{"title":"UJI TOKSISITAS EKSTRAK DAUN KENCUR (Kaempferia galanga L) DENGAN METODE BRINE SHRIMP LETHALY TEST (BSLT)","authors":"Linsih Umar, Hamsidar Hasan, Mahdalena Sy pakaya","doi":"10.37311/ijpe.v2i1.11283","DOIUrl":"https://doi.org/10.37311/ijpe.v2i1.11283","url":null,"abstract":"One of the plants that has potential as medicine is kencur(Kaemoferia galanga L). Many studies have asserted that the rhizome of kencur is useful for bacterial infections, cough medicine, dysentery, cold, and stomachache. Therefore, the research aimed to identify the toxic effect of kencur leaf extract on artemia salina larvae applying the BSLT (Brine shrimp lethaly test) method. It employed three concentration treatments using 10 artemia salina larvae that died after 48 hours. Futher, it was calculated by LC50with probit analysis. The result of probit analysis revealed that the value of LC50from n-hexane extract was 96,13µg/mL, ethyl acetate extract was 98,22 µg/mL and methanol extract of kencur leaf was 156,06 µg/mL. The LC50 value of the extract was in the active category, with the value of LC50was lower than 1000 ppm.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129457944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-03DOI: 10.37311/ijpe.v2i1.10772
Nazarudin Abto
Ketombe merupakan salah satu masalah kulit kepala yang disebabkan oleh jamur Malassezia furfur. Tanaman seledri (Apium graveolus L.) merupakan salah satu tanaman yang diketahui memiliki aktivitas sebagai antijamur. Tujuan dari penelitian ini adalah untuk memformulasikan ekstrak etanol seledri (Apium graveolus L.) menjadi sampo dan uji aktivitas antijamur terhadap jamur penyebab ketombe yaitu Malassezia furfur. Penelitian diawali dengan proses ekstraksi seledri dengan metode maserasi, kemudian dilakukan optimasi basis sampo dengan variasi konsentrasi cocamidopropyl betain 4%, 6%, 8% dan 10% sebagai surfaktan sekunder dan peningkat viskositas. Basis optimum yang terpilih yaitu basis dengan cocamidopropyl betain 10% kemudian diformulasikan dengan ekstrak etanol seledri (Apium graveolus L.) dengan konsentrasi 0,5%, 1% dan 2,5%. Setelah itu dilakukan evaluasi yang meliputi uji organoleptis, uji pH, uji viskositas, uji ketinggian busa, uji ketahanan busa seta uji kesukaan (hedonic). Pengujian aktivitas antijamur dilakukan dengan metode difusi cakram untuk melihat zona hambat. Hasil uji menunjukan sampo antiketombe ekstrak etanol seledri (Apium graveolus L.) menghasilkan diameter rata-rata area hambat masing-masing untuk F4a sebesar 4,3 mm, F4b 4,6 mm, dan F4c sebesar 6,6 mm. Hasil uji aktivitas antijamur diolah dengan metode One Way Anova dengan taraf kepercayaan 99% (α=0,01). Hasil penelitian menunjukkan bahwa sampo dengan ekstrak etanol seledri 0,5%, 1% dan 2,5% aktif dalam menghambat jamur Malassezia furfur dengan hasil analisis One Way Anova menunjukkan p=0,000 (sigα).
头皮屑是由马拉西亚·弗弗尔蘑菇引起的头皮问题之一。芹菜(Apium graveolus L)是已知的抗真菌活动之一。这项研究的目的是将一种叫做Apium graveolus L的乙醇提取物制成洗发水，并对头皮屑致病性真菌的抗真菌活性进行测试。该研究首先采用maserasi方法提取，然后通过次注射过程，对洗发水基础进行了优化，这种洗发水的浓度与次注射、6%、8%和10%的粘度发生了变化。当选即基地的最佳基地cocamidopropyl betain 10%然后用乙醇提取物研制芹菜(没有石油graveolus L)浓度为5%、1%和2004年。然后进行评估，包括有机蛋糕测试、pH测试、粘度测试、泡沫高度测试、最爱吃的seta泡沫持久性测试。抗真菌活性测试通过圆盘扩散方法看到拖住区域。化验结果显示洗发水antiketombe芹菜(没有石油graveolus L .)产生乙醇提取物等等区域分别为F4a平均直径4.3毫米,F4b 4.6毫米,F4c 6.6毫米大。抗真菌活性测试与One Way Anova方法加工程度99%(α= 0,01)的信任。研究结果表明,芹菜乙醇提取物。5%、1%和洗发水2004年积极参与抑制真菌Malassezia furfur One Way Anova分析表明的结果p =万sig(α)。
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Pub Date : 2021-11-03DOI: 10.37311/ijpe.v2i1.10995
Anggun Sasmita Ibrahim
Tumbuhan matoa (Pometia pinnata) adalah tumbuhan yang termasuk dalam famili Sapindaceae yang menyebar pada daerah tropis, termasuk Indonesia yang bisa dimanfaatkan sebagai antioksidan. Tanaman matoa diketahui memiliki kandungan senyawa flavonoid. Dimana flavonoid merupakan zat yang mempunyai sifat antioksidan dalam menangkap radikal bebas sebab terkandung gugus hidroksil yang sifatnya untuk reduktor dan bisa berguna untuk donor hidrogen terhadap radikal bebas. Penelitian ini bertujuan untuk mengetahui kandungan kimia dan aktivitas antioksidan kulit batang matoa (Pometia pinnata) dengan menggunakan metode 1,1-Diphenyl-2-Picrylhydrazyl (DPPH). Ekstraksi sampel dilakukan dengan metode ekstraksi bertingkat menggunakan pelarut n-heksan, kloroform, etil asetat dan etanol. Hasil penelitian menunjukkan ekstrak kulit batang matoa (Pometia pinnata) mengandung senyawa Alkaloid, Flavonoid, Saponin, Tanin Steroid dan Terpenoid. Sedangkan nilai aktivitas antioksidan menunjukkan nilai IC50 ekstrak n-heksan, kloroform, etil asetat dan etanol yaitu 25, 5, 9, 4 μg/mL. Nilai IC50 menunjukkan bahwa aktivitas antioksidan adalah kategori sangat kuat. Pometia pinnata is a plant belonging to the Sapindaceae family that spread in the tropics, including Indonesia, which can be used as antioxidants. It is known to contain flavonoid compounds. Flavonoid is a substance that has antioxidants in capturing free radicals because it contains a hydroxyl group which is a reducer and can be beneficial for hydrogen donors to free radicals. This study aims to determine the chemical content and antioxidant activity of Pometia pinnata skin using 1,1-Diphenyl-2-Picrylhidrazyl (DPPH). Sample extraction was conducted using a multilevel extraction method with n-hexane, chloroform, ethyl acetate, and ethanol as solvents. The results showed that Pometia pinnata skin extract contains Alkaloids, Flavonoids, Saponins, Tannins, Steroids, and Terpenoids. While the value of antioxidant activity showed the IC50 value of n-hexane, chloroform, ethyl acetate, and ethanol extracts are 25, 5, 9, 4 µg/mL. The IC50 value indicates that the antioxidant activity is in an extremely strong category.
{"title":"SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN KULIT BATANG MATOA (Pometia pinnata) DENGAN METODE 1,1-DIPHENYL-2-PICRYLHIDRAZYL (DPPH)","authors":"Anggun Sasmita Ibrahim","doi":"10.37311/ijpe.v2i1.10995","DOIUrl":"https://doi.org/10.37311/ijpe.v2i1.10995","url":null,"abstract":"Tumbuhan matoa (Pometia pinnata) adalah tumbuhan yang termasuk dalam famili Sapindaceae yang menyebar pada daerah tropis, termasuk Indonesia yang bisa dimanfaatkan sebagai antioksidan. Tanaman matoa diketahui memiliki kandungan senyawa flavonoid. Dimana flavonoid merupakan zat yang mempunyai sifat antioksidan dalam menangkap radikal bebas sebab terkandung gugus hidroksil yang sifatnya untuk reduktor dan bisa berguna untuk donor hidrogen terhadap radikal bebas. Penelitian ini bertujuan untuk mengetahui kandungan kimia dan aktivitas antioksidan kulit batang matoa (Pometia pinnata) dengan menggunakan metode 1,1-Diphenyl-2-Picrylhydrazyl (DPPH). Ekstraksi sampel dilakukan dengan metode ekstraksi bertingkat menggunakan pelarut n-heksan, kloroform, etil asetat dan etanol. Hasil penelitian menunjukkan ekstrak kulit batang matoa (Pometia pinnata) mengandung senyawa Alkaloid, Flavonoid, Saponin, Tanin Steroid dan Terpenoid. Sedangkan nilai aktivitas antioksidan menunjukkan nilai IC50 ekstrak n-heksan, kloroform, etil asetat dan etanol yaitu 25, 5, 9, 4 μg/mL. Nilai IC50 menunjukkan bahwa aktivitas antioksidan adalah kategori sangat kuat. Pometia pinnata is a plant belonging to the Sapindaceae family that spread in the tropics, including Indonesia, which can be used as antioxidants. It is known to contain flavonoid compounds. Flavonoid is a substance that has antioxidants in capturing free radicals because it contains a hydroxyl group which is a reducer and can be beneficial for hydrogen donors to free radicals. This study aims to determine the chemical content and antioxidant activity of Pometia pinnata skin using 1,1-Diphenyl-2-Picrylhidrazyl (DPPH). Sample extraction was conducted using a multilevel extraction method with n-hexane, chloroform, ethyl acetate, and ethanol as solvents. The results showed that Pometia pinnata skin extract contains Alkaloids, Flavonoids, Saponins, Tannins, Steroids, and Terpenoids. While the value of antioxidant activity showed the IC50 value of n-hexane, chloroform, ethyl acetate, and ethanol extracts are 25, 5, 9, 4 µg/mL. The IC50 value indicates that the antioxidant activity is in an extremely strong category.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127945855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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