Pub Date : 2023-05-05DOI: 10.37311/ijpe.v3i1.18063
Teti sutriyati Tuloli, W. Abdulkadir, Mohamad Aprianto Paneo, N. Abdullah
Covid-19 is a source of problem in the world because of the continuous increse. Due to the number of cases exposed, thus it is necessary to take preventive measures to break the spread of the Covid-19 virus. Covid-19 for Covid-19 is an effort to protect oneself against or to attack the disease and increase the immune system. In general, the sommunities cannot receive vaccinations becaus they are concerned about the safety and effectiveness of vaccines. However, understanding and accepting the Covid-19 vaccine in Indonesia continues to increase. This research aims to detemine the level of public knowledge and perception and the relationship between knowledge and perception of the Covid-19 vaccine in the Limba U II Village, Kota Selatan Subdistric, Gorontalo City. This research employs observational research with a descriptive quantitative design and a cross-sectional approach. In this research, 372 samples are obtained from the questionnaire distribution. Data are analyzed using Chi-Square. The results indicate that the level of public knowledge in Limba U II Village about the Covid-19 vaccine is the high category (60%), and the public perception in Limba U II Village is in a postivie category (62,1%). The relationship between the two shows significant results with P-Value = 0,000, where the value is less than 0,05.
新冠肺炎疫情持续增加，成为世界问题之源。由于暴露病例众多，因此有必要采取预防措施，以打破新冠病毒的传播。Covid-19是一种保护自己免受或攻击疾病并增强免疫系统的努力。一般来说，社区不能接种疫苗，因为他们担心疫苗的安全性和有效性。然而，印度尼西亚对Covid-19疫苗的理解和接受程度在不断增加。本研究旨在确定哥伦塔洛市Kota Selatan街道Limba U II村公众对Covid-19疫苗的知识和认知水平以及知识和认知之间的关系。本研究采用描述性定量设计和横断面方法的观察性研究。在本研究中，通过问卷的发放，获得了372个样本。数据采用卡方分析。结果表明，林巴U II村公众对新冠肺炎疫苗的知晓程度为高(60%)，公众对新冠肺炎疫苗的认知程度为高(62.1%)。两者之间的关系具有显著性，p值= 0000，其中p值小于0.05。
{"title":"Tingkat Pengetahuan Dan Persepsi Masyarakat Tentang Vaksin Covid-19 Studi Kasus : Kota Gorontalo","authors":"Teti sutriyati Tuloli, W. Abdulkadir, Mohamad Aprianto Paneo, N. Abdullah","doi":"10.37311/ijpe.v3i1.18063","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.18063","url":null,"abstract":"Covid-19 is a source of problem in the world because of the continuous increse. Due to the number of cases exposed, thus it is necessary to take preventive measures to break the spread of the Covid-19 virus. Covid-19 for Covid-19 is an effort to protect oneself against or to attack the disease and increase the immune system. In general, the sommunities cannot receive vaccinations becaus they are concerned about the safety and effectiveness of vaccines. However, understanding and accepting the Covid-19 vaccine in Indonesia continues to increase. This research aims to detemine the level of public knowledge and perception and the relationship between knowledge and perception of the Covid-19 vaccine in the Limba U II Village, Kota Selatan Subdistric, Gorontalo City. This research employs observational research with a descriptive quantitative design and a cross-sectional approach. In this research, 372 samples are obtained from the questionnaire distribution. Data are analyzed using Chi-Square. The results indicate that the level of public knowledge in Limba U II Village about the Covid-19 vaccine is the high category (60%), and the public perception in Limba U II Village is in a postivie category (62,1%). The relationship between the two shows significant results with P-Value = 0,000, where the value is less than 0,05.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126263252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-06DOI: 10.37311/ijpe.v2i3.19326
Dewi Darmiyani Napu
Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test of its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde and 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis was performed by using KOH 40% under stirring at room temperature for 48 h. The synthesized compounds was characterized using FTIR, GC-MS and 1H NMR spectrometers. Further, the chalcone were screened for its in vitro sunscreen activity by using UV-Vis spectrophotometer. The result showed that the chalcone has been succesfully synthesized in 36.94% Yield. The activity of invitro test showed the chalcone has SPF values with maximal protection category at the consentration 15 µ/mL produce SPF 9.749
{"title":"Sintesis Khalkon dan Uji Aktivitas Tabir Surya Secara In Vitro","authors":"Dewi Darmiyani Napu","doi":"10.37311/ijpe.v2i3.19326","DOIUrl":"https://doi.org/10.37311/ijpe.v2i3.19326","url":null,"abstract":"Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test of its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde and 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis was performed by using KOH 40% under stirring at room temperature for 48 h. The synthesized compounds was characterized using FTIR, GC-MS and 1H NMR spectrometers. Further, the chalcone were screened for its in vitro sunscreen activity by using UV-Vis spectrophotometer. The result showed that the chalcone has been succesfully synthesized in 36.94% Yield. The activity of invitro test showed the chalcone has SPF values with maximal protection category at the consentration 15 µ/mL produce SPF 9.749","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130401359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.37311/ijpe.v3i1.19276
Prita Laoura, Nurmainah Nurmainah, Ressi Susanti
Non-communicable diseases (PMT) have increased globally and nationally which have occupied the top ten causes of death with the most cases being diabetes mellitus. Diabetes Mellitus is a chronic disease that occurs due to impaired insulin action which causes blood sugar levels to increase. Uncontrolled sugar levels cause complications, one of which is diabetic ulcers. This study aims to analyze the level of adherence in taking medication in patients and the factors that influence adherence in taking medication in diabetic ulcer patients at Clinic Pontianak. The method used in this research is analytic observational method with the research design used is a cohort study. Compliance with drug use was measured using the Medication Possession Ratio (MPR) method. Data collection was carried out retrospectively based on manual and electronic data collection (medical records) and outpatient diabetic ulcer patient prescriptions at the Clinic Pontianak from January to December. Analysis of compliance relationship data using the chi square test. The results of this study showed that patients tended to be 45 years old (16.7%), female sex (87.5%), and monotherapy regimen (87.3%), this stated that there was no significant relationship between compliance with patient characteristics. Based on the results of the research, the percentage of compliance with the use of oral anti-diabetic drugs in outpatient diabetic ulcer patients at the Pontianak Clinic in 2021 is 26.1%.
{"title":"Kepatuhan Minum Obat Antidiabetika Oral Pasien Ulkus Diabetikum Rawat Jalan di Klinik X Kota Pontianak Menggunakan Metode Kuantitatif","authors":"Prita Laoura, Nurmainah Nurmainah, Ressi Susanti","doi":"10.37311/ijpe.v3i1.19276","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19276","url":null,"abstract":"Non-communicable diseases (PMT) have increased globally and nationally which have occupied the top ten causes of death with the most cases being diabetes mellitus. Diabetes Mellitus is a chronic disease that occurs due to impaired insulin action which causes blood sugar levels to increase. Uncontrolled sugar levels cause complications, one of which is diabetic ulcers. This study aims to analyze the level of adherence in taking medication in patients and the factors that influence adherence in taking medication in diabetic ulcer patients at Clinic Pontianak. The method used in this research is analytic observational method with the research design used is a cohort study. Compliance with drug use was measured using the Medication Possession Ratio (MPR) method. Data collection was carried out retrospectively based on manual and electronic data collection (medical records) and outpatient diabetic ulcer patient prescriptions at the Clinic Pontianak from January to December. Analysis of compliance relationship data using the chi square test. The results of this study showed that patients tended to be 45 years old (16.7%), female sex (87.5%), and monotherapy regimen (87.3%), this stated that there was no significant relationship between compliance with patient characteristics. Based on the results of the research, the percentage of compliance with the use of oral anti-diabetic drugs in outpatient diabetic ulcer patients at the Pontianak Clinic in 2021 is 26.1%.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129980498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Compliance is a major factor in determining the success of treatment. Non-compliance with taking medication in patients with diabetes mellitus has an impact on the risk of complications, one of which is diabetic ulcers. Diabetic ulcers are chronic wounds that occur due to hyperglycemia and abnormal blood circulation, which causes an increase in blood sugar levels. This study aims to analyze the level of adherence to taking oral antidiabetic drugs and the factors that influence adherence to taking antidiabetic drugs in outpatient diabetic ulcer patients at X Clinic, Pontianak. This research is a type of cross-sectional research, the sampling technique is purposive sampling. The number of samples that met the inclusion and exclusion criteria was 100 patients. Data was collected by filling out a questionnaire. Medication adherence was measured using the Morisky Medication Adherence Scale (MMAS-8) questionnaire. The results showed that the characteristics of patients who visited the X Clinic Pontianak tended to be 45 years old (85%), female (67%), patients with 5 years of illness (55%), patients with a single type of treatment ( 68%), patients taking metformin (47%), and only 27% of patients adhering to oral antidiabetic drugs. Chi-square analysis showed that there was no significant relationship between age (p=1,000), gender (p=0,966), length of stay (p=0,946), type of treatment (p=0,202) on patient compliance in using antidiabetic drugs. From this study, it can be concluded that age, gender, length of suffering, and type of treatment do not affect adherence to taking oral antidiabetic drugs in diabetic ulcer patients.
{"title":"Kepatuhan Minum Obat Antidiabetika Oral Pasien Ulkus Diabetikum Rawat Jalan di Klinik X Pontianak Menggunakan Metode Kualitatif MMAS-8","authors":"Yunike Dwi Larasati, Nurmainah Nurmainah, Ressi Susanti","doi":"10.37311/ijpe.v3i1.19278","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19278","url":null,"abstract":"Compliance is a major factor in determining the success of treatment. Non-compliance with taking medication in patients with diabetes mellitus has an impact on the risk of complications, one of which is diabetic ulcers. Diabetic ulcers are chronic wounds that occur due to hyperglycemia and abnormal blood circulation, which causes an increase in blood sugar levels. This study aims to analyze the level of adherence to taking oral antidiabetic drugs and the factors that influence adherence to taking antidiabetic drugs in outpatient diabetic ulcer patients at X Clinic, Pontianak. This research is a type of cross-sectional research, the sampling technique is purposive sampling. The number of samples that met the inclusion and exclusion criteria was 100 patients. Data was collected by filling out a questionnaire. Medication adherence was measured using the Morisky Medication Adherence Scale (MMAS-8) questionnaire. The results showed that the characteristics of patients who visited the X Clinic Pontianak tended to be 45 years old (85%), female (67%), patients with 5 years of illness (55%), patients with a single type of treatment ( 68%), patients taking metformin (47%), and only 27% of patients adhering to oral antidiabetic drugs. Chi-square analysis showed that there was no significant relationship between age (p=1,000), gender (p=0,966), length of stay (p=0,946), type of treatment (p=0,202) on patient compliance in using antidiabetic drugs. From this study, it can be concluded that age, gender, length of suffering, and type of treatment do not affect adherence to taking oral antidiabetic drugs in diabetic ulcer patients.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122815467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.37311/ijpe.v3i1.19277
Oni Astri Herdani, Nurmainah Nurmainah, R. Susanti
Diabetic ulcers are a complication of diabetes mellitus. Diabetic ulcers are caused by poor circulation associated with peripheral neuropathy and peripheral vascular disease that can lead to infection. To prevent or treat infections, proper treatment is needed, one of which is by using antibiotic therapy. Inappropriate use of antibiotics can lead to an increased risk of antibiotic resistance. This study aims to describe the pattern of antibiotic use in patients with type 2 diabetes mellitus with complications of diabetic ulcers and the rationale for their use. This study uses a descriptive observational method with a cross-sectional research design. Retrospective data collection using a purposive sampling method. The results showed that the characteristics of patients with type 2 diabetes mellitus with complications of diabetic ulcers by gender were most common in women (65%) compared to men (35%), and most occurred in the age range 55-64 years (44%) with the most severe level in grade III (86%). The pattern of antibiotic use used was antibiotics with single therapy (93%) compared to combination antibiotics (7%). The single most widely used antibiotic was cefixime (31%). Evaluation of the accuracy of the use of antibiotics is the right dose (93.45%) and the right time interval of administration (83.17%).
{"title":"Evaluation of The Use of Antibiotic Drugs in Outstanding Patients with Diabetes Mellitus with Complications of Diabetic Ulcus in Clinic X Pontianak","authors":"Oni Astri Herdani, Nurmainah Nurmainah, R. Susanti","doi":"10.37311/ijpe.v3i1.19277","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19277","url":null,"abstract":"Diabetic ulcers are a complication of diabetes mellitus. Diabetic ulcers are caused by poor circulation associated with peripheral neuropathy and peripheral vascular disease that can lead to infection. To prevent or treat infections, proper treatment is needed, one of which is by using antibiotic therapy. Inappropriate use of antibiotics can lead to an increased risk of antibiotic resistance. This study aims to describe the pattern of antibiotic use in patients with type 2 diabetes mellitus with complications of diabetic ulcers and the rationale for their use. This study uses a descriptive observational method with a cross-sectional research design. Retrospective data collection using a purposive sampling method. The results showed that the characteristics of patients with type 2 diabetes mellitus with complications of diabetic ulcers by gender were most common in women (65%) compared to men (35%), and most occurred in the age range 55-64 years (44%) with the most severe level in grade III (86%). The pattern of antibiotic use used was antibiotics with single therapy (93%) compared to combination antibiotics (7%). The single most widely used antibiotic was cefixime (31%). Evaluation of the accuracy of the use of antibiotics is the right dose (93.45%) and the right time interval of administration (83.17%).","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123560073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-24DOI: 10.37311/ijpe.v3i1.19231
Z. Ahmad, Nadila Salsabila Mongilong, Laksmyn Kadir, St. Surya Indah Nurdin, Dewi Rahmawaty Moo
Dengue hemorrhagic fever has spread throughout the region, especially in tropical and warm climates. Dengue fever has become a global health problem and causes outbreaks almost every year. This study aims to compare the clinical manifestations of DHF patients in pediatrics and adults. This study used a health center-based cross-sectional approach and used secondary data on DHF sufferers from 2019-2022 at the Tutuyan Health Center, namely 72 sufferers. Clinical manifestations of fever are symptoms that generally appear in patients with DHF (100%), and headaches (72.2%), vomiting (40.3%), nausea (34.7%). Meanwhile, the few symptoms found were abdominal pain (15.3%), aches (15.3%), rash (11.1%), joint pain (9.7%), and seizures (8.3%). Abdominal pain, joint pain, aches, nausea, and vomiting are commonly found in adults, while rashes and seizures are commonly found in pediatrics. More efforts are needed to strengthen national programs and thereby reduce the morbidity, mortality, and social and economic burden generated by DHF outbreaks and epidemics
{"title":"Perbandingan Manifestasi Klinis Penderita Demam Berdarah","authors":"Z. Ahmad, Nadila Salsabila Mongilong, Laksmyn Kadir, St. Surya Indah Nurdin, Dewi Rahmawaty Moo","doi":"10.37311/ijpe.v3i1.19231","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19231","url":null,"abstract":"Dengue hemorrhagic fever has spread throughout the region, especially in tropical and warm climates. Dengue fever has become a global health problem and causes outbreaks almost every year. This study aims to compare the clinical manifestations of DHF patients in pediatrics and adults. This study used a health center-based cross-sectional approach and used secondary data on DHF sufferers from 2019-2022 at the Tutuyan Health Center, namely 72 sufferers. Clinical manifestations of fever are symptoms that generally appear in patients with DHF (100%), and headaches (72.2%), vomiting (40.3%), nausea (34.7%). Meanwhile, the few symptoms found were abdominal pain (15.3%), aches (15.3%), rash (11.1%), joint pain (9.7%), and seizures (8.3%). Abdominal pain, joint pain, aches, nausea, and vomiting are commonly found in adults, while rashes and seizures are commonly found in pediatrics. More efforts are needed to strengthen national programs and thereby reduce the morbidity, mortality, and social and economic burden generated by DHF outbreaks and epidemics","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129623577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-13DOI: 10.37311/ijpe.v3i1.19135
N. Istiqomah, Safitri Fatikasari
Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes, which mediates membrane permeability and fluidity. One way to treat candidiasis is to use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal medicine. Drug development efforts can be done using the In silico method. Objectives of this study was to determine the interaction between terpenoid, flavonoid, and phenol compounds in Sungkai leaves against Lanosterol 14-α demethylase in Candida albicans. The research design used was a pre-experimental one-shot case study. Toxtree software was used to test the toxicity of compounds. Test for compound potency using the Pass Online webserver. Docking molecular using PyRx software. Visualization of docking results using Discovery Studio 2019 Software. Physicochemical test of compounds using Lipinski Test. The results showed that the compounds that had a low risk of toxicity were butanoic, catechol, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and phytol. Compounds that have anti-fungal activity based on Pharma-expert analysis are butanoic acid, genkwanin, guaiacol, hydroquinone, isopropanol, palmitic acid, and phytol. Compounds that have hydrogen bonds and binding affinity value 10 and RMSD value 2 are butanoic acid, catechol, genkwanin, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and quinic acid compounds. These compounds are thought to inhibit the Lanosterol 14-alpha demethylase enzyme in C. albicans. Compounds that comply with Lipinski's rules are anthocyanin and genkwanin compounds. The groups of compounds found in Sungkai leaves that have antifungal activity are the terpenoids, flavonoids, and phenols.
白色念珠菌(C. albicans)是一种引起念珠菌病的真菌。白色念珠菌具有羊毛甾醇14- α去甲基化酶。羊毛甾醇14-α-去甲基化酶具有将羊毛甾醇转化为麦角甾醇的生物活性，麦角甾醇是一种在真菌膜中发现的特殊甾醇，介导膜的通透性和流动性。治疗念珠菌病的一种方法是使用传统药用植物。Sungkai (Peronema canescens)可以用作抗真菌药。药物开发工作可以使用计算机方法完成。本研究的目的是确定松开叶中萜类、黄酮类和酚类化合物对白色念珠菌羊毛甾醇14-α去甲基化酶的相互作用。使用的研究设计是实验前的一次性案例研究。使用Toxtree软件测试化合物的毒性。使用Pass在线web服务器测试复方效价。利用PyRx软件对接分子。使用Discovery Studio 2019软件可视化对接结果。使用利平斯基试验对化合物进行理化试验。结果表明，毒性风险较低的化合物为丁酸、儿茶酚、愈创木酚、对苯二酚、异丙醇、甲醇酸、棕榈酸和叶绿醇。经药学专家分析，具有抗真菌活性的化合物有丁酸、根宽素、愈创木酚、对苯二酚、异丙醇、棕榈酸和叶绿醇。具有氢键且结合亲和值为10和RMSD值为2的化合物有丁酸、儿茶酚、根宽素、愈创木酚、对苯二酚、异丙醇、甲醇酸、棕榈酸和奎宁酸化合物。这些化合物被认为可以抑制白色念珠菌中的羊毛甾醇14- α去甲基酶。符合利平斯基规则的化合物是花青素和根宽素化合物。在松开叶中发现的具有抗真菌活性的化合物是萜类化合物、黄酮类化合物和酚类化合物。
{"title":"Kajian in Silico Daun Sungkai (Peronema canescens) dalam Menghambat Enzim lanosterol 14-α demethylase Jamur Candida albicans","authors":"N. Istiqomah, Safitri Fatikasari","doi":"10.37311/ijpe.v3i1.19135","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19135","url":null,"abstract":"Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes, which mediates membrane permeability and fluidity. One way to treat candidiasis is to use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal medicine. Drug development efforts can be done using the In silico method. Objectives of this study was to determine the interaction between terpenoid, flavonoid, and phenol compounds in Sungkai leaves against Lanosterol 14-α demethylase in Candida albicans. The research design used was a pre-experimental one-shot case study. Toxtree software was used to test the toxicity of compounds. Test for compound potency using the Pass Online webserver. Docking molecular using PyRx software. Visualization of docking results using Discovery Studio 2019 Software. Physicochemical test of compounds using Lipinski Test. The results showed that the compounds that had a low risk of toxicity were butanoic, catechol, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and phytol. Compounds that have anti-fungal activity based on Pharma-expert analysis are butanoic acid, genkwanin, guaiacol, hydroquinone, isopropanol, palmitic acid, and phytol. Compounds that have hydrogen bonds and binding affinity value 10 and RMSD value 2 are butanoic acid, catechol, genkwanin, guaiacol, hydroquinone, isopropanol, methanoic acid, palmitic acid, and quinic acid compounds. These compounds are thought to inhibit the Lanosterol 14-alpha demethylase enzyme in C. albicans. Compounds that comply with Lipinski's rules are anthocyanin and genkwanin compounds. The groups of compounds found in Sungkai leaves that have antifungal activity are the terpenoids, flavonoids, and phenols.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122523929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetic Mellitus is a chronic disease caused a limited or inneffective insulin produced by pancreas. Diabetes is a big health problems that has reached an worry level and is a global threat. A knowledge has an important role for behavior. This research is used to look a correlation between level of knowledge with of blood sugar levels in patients of diabetic mellitus at the X Health Center. This research used an analytic survey design with a cross-sectional program. The samples was 93 patients with inclusion criteria in the form in patient of diabetic mellitus at the X Health Center and willing to be respondents. This research was held in December 2022 until January 2023. The research used instrument a questionnaire sheet by DKQ 24. The results of the univariate research were obtained by 64,5% of patient had a good levels knowledge and 35,5% had a not good level of knowledge, 60,2% of patient had a normal blood sugar levels and 39,8% of patient had abnormal blood sugar levels. The bivariate with a Chi-Square statistical test found that there a correlation between the level of knowledge with of blood sugar levels in diabetic mellitus patients at the X Health Center in Kediri City with a P value of 0.014. From this research it can be conclude that there a significant correlation between the level knowledge with of blood sugar levels patients of diabetic mellitus at the X Health Center. Hoped the results this research will give information to the X Health Center to continue providing education about diabetes mellitus to patients as a support the stability of the patient's blood sugar levels with a better life.
{"title":"Hubungan Tingkat Pengetahuan Diabetes Mellitus Terhadap Kadar Gula Darah Pasien Diabetes Mellitus di Puskesmas X","authors":"Umul Farida, Djembor Sugeng Walujo, Nanda Aulia Mar�atina","doi":"10.37311/ijpe.v3i1.19052","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19052","url":null,"abstract":"Diabetic Mellitus is a chronic disease caused a limited or inneffective insulin produced by pancreas. Diabetes is a big health problems that has reached an worry level and is a global threat. A knowledge has an important role for behavior. This research is used to look a correlation between level of knowledge with of blood sugar levels in patients of diabetic mellitus at the X Health Center. This research used an analytic survey design with a cross-sectional program. The samples was 93 patients with inclusion criteria in the form in patient of diabetic mellitus at the X Health Center and willing to be respondents. This research was held in December 2022 until January 2023. The research used instrument a questionnaire sheet by DKQ 24. The results of the univariate research were obtained by 64,5% of patient had a good levels knowledge and 35,5% had a not good level of knowledge, 60,2% of patient had a normal blood sugar levels and 39,8% of patient had abnormal blood sugar levels. The bivariate with a Chi-Square statistical test found that there a correlation between the level of knowledge with of blood sugar levels in diabetic mellitus patients at the X Health Center in Kediri City with a P value of 0.014. From this research it can be conclude that there a significant correlation between the level knowledge with of blood sugar levels patients of diabetic mellitus at the X Health Center. Hoped the results this research will give information to the X Health Center to continue providing education about diabetes mellitus to patients as a support the stability of the patient's blood sugar levels with a better life.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131586558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-08DOI: 10.37311/ijpe.v3i1.14612
Robert Tungadi, Mahdalena Sy. Pakaya, Priliya Wati D.as'ali
This study aims to formulate and evaluate the preparation of an anti-aging cream made from astaxanthin. Astaxanthin has antioxidant activity, as well as other carotenoid compounds. Astaxanthin shows more significant antioxidant activity than ?-carotene; thus,developing astaxanthin compounds in cream preparations is necessary. This type of experimental laboratory research compares three different concentrations of astaxanthin compounds, including formula I (0.5%), formula II (0.75%), and formula III (1%). Evaluation of the astaxanthin compound cream preparations stability included organoleptic observations (smell, color, texture), pH test, homogeneity test, viscosity test, spreadability test, adhesion test, and freeze-thaw test. The results of the quality inspection of organoleptic preparations revealed no difference between the preparations in the form of color, smell, and texture.The homogeneity test showed a homogeneous preparation; the pH test produced was 5.5-5.8, the viscosity test of the preparation produced was 5140 Cp, 5250 Cp, and 7000 Cp, the adhesion test was 6.40-7.83 seconds, the dispersion test was 5-5.9 cm, and the Freeze-thaw test showed that there was no significant change in the pH test, organoleptic test, spreadability, adhesion, homogeneity, and viscosity. Thus, it can be concluded that the three astaxanthin compound cream formulas have good stability.
{"title":"Formulasi dan Evaluasi Stabilitas Fisik Sediaan Krim Senyawa Astaxanthin","authors":"Robert Tungadi, Mahdalena Sy. Pakaya, Priliya Wati D.as'ali","doi":"10.37311/ijpe.v3i1.14612","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.14612","url":null,"abstract":"This study aims to formulate and evaluate the preparation of an anti-aging cream made from astaxanthin. Astaxanthin has antioxidant activity, as well as other carotenoid compounds. Astaxanthin shows more significant antioxidant activity than ?-carotene; thus,developing astaxanthin compounds in cream preparations is necessary. This type of experimental laboratory research compares three different concentrations of astaxanthin compounds, including formula I (0.5%), formula II (0.75%), and formula III (1%). Evaluation of the astaxanthin compound cream preparations stability included organoleptic observations (smell, color, texture), pH test, homogeneity test, viscosity test, spreadability test, adhesion test, and freeze-thaw test. The results of the quality inspection of organoleptic preparations revealed no difference between the preparations in the form of color, smell, and texture.The homogeneity test showed a homogeneous preparation; the pH test produced was 5.5-5.8, the viscosity test of the preparation produced was 5140 Cp, 5250 Cp, and 7000 Cp, the adhesion test was 6.40-7.83 seconds, the dispersion test was 5-5.9 cm, and the Freeze-thaw test showed that there was no significant change in the pH test, organoleptic test, spreadability, adhesion, homogeneity, and viscosity. Thus, it can be concluded that the three astaxanthin compound cream formulas have good stability.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"36 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134268879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-04DOI: 10.37311/ijpe.v3i1.19008
Novia Agustina, Diana Pratiwi, Nurul Istiqomah
Diabetes Mellitus (DM) is a chronic metabolic disorder. DM can occur if the pancreas does not produce enough insulin or the insulin that is produced isn’t effectively used. Patients with diabetes mellitus have a high risk for chronic microvascular complications, including infection. This research aimed to determine the correlation between leukocytes and bacterial number from urine of patients with Type 2 Diabetes Mellitus at the X Hospital Blitar. This research used a cross sectional method, with 47 urine samples of Type 2 Diabetes Mellitus patients by purposive sampling, were tested with urine analyzer. The result showed that the number of high leukocytes was 13 (28%) respondents and normal leukocytes was 34 (72%) respondents. While the number of bacteria from respondents was normal 21 (45%) and high number was 26 (55%). Based on the Spearman-rho correlation test on SPSS, it can be concluded that there was a significant relationship between leukocytes with bacterial number of urine from Type 2 Diabetes Mellitus patients, with sig = 0,000 (0,05) and the correlation coefficient = 0,515.
{"title":"The Correlation between Leukocytes and Bacterial Number from Urine of Type 2 Diabetes Mellitus Patients Using Urine Analyzer","authors":"Novia Agustina, Diana Pratiwi, Nurul Istiqomah","doi":"10.37311/ijpe.v3i1.19008","DOIUrl":"https://doi.org/10.37311/ijpe.v3i1.19008","url":null,"abstract":"Diabetes Mellitus (DM) is a chronic metabolic disorder. DM can occur if the pancreas does not produce enough insulin or the insulin that is produced isn’t effectively used. Patients with diabetes mellitus have a high risk for chronic microvascular complications, including infection. This research aimed to determine the correlation between leukocytes and bacterial number from urine of patients with Type 2 Diabetes Mellitus at the X Hospital Blitar. This research used a cross sectional method, with 47 urine samples of Type 2 Diabetes Mellitus patients by purposive sampling, were tested with urine analyzer. The result showed that the number of high leukocytes was 13 (28%) respondents and normal leukocytes was 34 (72%) respondents. While the number of bacteria from respondents was normal 21 (45%) and high number was 26 (55%). Based on the Spearman-rho correlation test on SPSS, it can be concluded that there was a significant relationship between leukocytes with bacterial number of urine from Type 2 Diabetes Mellitus patients, with sig = 0,000 (0,05) and the correlation coefficient = 0,515.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126563539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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