ACS Sensors最新文献

The need for efficient and reliable gas sensors has grown significantly due to increasing industrial activities, transportation, and environmental pollution, posing serious risks to human health and the environment. Advanced sensor technologies are crucial for detecting these harmful gases at low concentrations with a high accuracy. Nickel oxide, a p-type metal oxide semiconductor, has emerged as a promising candidate for gas sensing applications owing to its unique and excellent structural, electronic, and catalytic properties along with its high chemical stability. Interestingly, the possibility to synthesize NiO in versatile nanostructure forms: nanowires, nanoflowers, and nanospheres, helps to enhance surface area and porosity, which are critical factors to improve gas adsorption and diffusion. This review presents a comprehensive and critical assessment of the latest advancements in the synthesis, characterization, and gas-sensing performance of NiO nanostructures. We explore how structural modifications, such as decoration with noble metal nanoparticles, formation of different composites, and surface functionalization with self-assembly enhance the sensitivity, selectivity, and operational temperature of NiO sensors. Particular focus is given to the integration of NiO in novel nanoheterostructures, where the formation of p-n and p-p junctions significantly improves charge transport and overall sensor response. Finally, we identify current challenges in reproducibility, stability, and operating conditions, while offering directions for future research on tailoring NiO nanostructures for more effective, scalable, and robust sensor technologies.

With the rapid emergence of flexible electronics, flexible pressure sensors are of importance in various fields. In this study, a dopamine-modified melamine sponge (MS) was used to prepare a honeycomb structure of carbon black (CB)/MXene-silicone rubber (SR)@MS flexible pressure sensor (CMSM) through layer-by-layer self-assembly technology. Using SR as a binder to construct the honeycomb structure not only improves the mechanical properties of the sensor but also provides more attachment sites for CB/MXene, enhancing the stability of the conductive network. The honeycomb structure CMSM flexible pressure sensor exhibits high sensitivity (7.44 kPa^–1), a wide detection range (0–240 kPa), short response/recovery times (150 ms/180 ms), and exhibits excellent stability. In addition, a flexible smart insole has been developed based on a 6-unit CMSM sensor array, achieving plantar pressure detection. By combination of the ResNet-50 neural network algorithm with plantar pressure data under different postures, the recognition of 16 types of human motion postures has been achieved, with an accuracy rate of 90.63%. This study proposes a flexible sponge pressure sensor with excellent mechanical performance and sensing capabilities, providing new ideas and references for the design of flexible wearable sensor devices.

The surface-induced ordering of liquid crystals (LC) has been harnessed to detect a wide range of chemical and biological stimuli. In most sensor designs, the information-rich response of the LC is transduced from an analyte-triggered change in the out-of-plane orientation of the LC. Quantifying the out-of-plane LC orientation, however, is often complicated by simultaneous changes in the in-plane orientation of the LC when using polarized light for transduction. Here we introduce a sensing approach that combines a dichroic dye-doped LC (DDLC) with unpolarized light and a photodiode to achieve precise quantification of analyte-driven changes in the out-of-plane orientations of LCs. We benchmark the performance of the new methodology against polarizer-based approaches using a model amphiphilic analyte in aqueous solution and show that the DDLC provides a substantial reduction in the coefficient of variation (300% to less than 5%), an enhanced analytical sensitivity (0.16 to 3.73 μM^–1), and an expanded dynamic range. In addition, when used to sense concentration gradients of analytes, the new approach distinguishes differences as small as 0.03 μM/μm over a dynamic range of 2 μM/μm, significantly outperforming conventional polarizer-based approaches that detect differences of 0.3 μM/μm over a dynamic range of 0.6 μM/μm. Overall, we conclude that the improved sensing performance and simpler implementation (no polarizers) of the DDLC approach, as compared to conventional LC sensors based on crossed-polars, will facilitate the deployment of LC sensors in diverse contexts, including the development of high-throughput screens for chemical formulations.

In clinical diagnosis, the determination of target proteins at low concentration levels is generally performed by immunoassays, such as the enzyme-linked immunosorbent assay (ELISA), which is a time-consuming process. To date, paper-based ELISA platforms enabling faster and less expensive analysis have been developed, but their important issue for clinical applications is the limited sensitivity compared to conventional ELISA. To address this challenge, this paper introduces a simple, rapid, and highly sensitive detection method for non-nucleic acid targets achieved by integrating the CRISPR/Cas12a system into paper-based ELISA. An origami-type paper-based device enabling simple assay operation has been designed, and the detection of targets on the paper substrates is based on observing the fluorescence signal induced by the CRISPR/Cas12a enzyme cleaving a probe single-stranded DNA (ssDNA) labeled with fluorophore and quencher (FQ reporter). To enhance sensitivity, antibodies labeled with a network of multiple DNA activating the CRISPR/Cas12a enzyme have been utilized as detection antibodies. As a result, the developed device successfully boosted the detection sensitivity for both human IgG and the hepatitis B virus surface antigen (HBsAg). In particular, the limit of detection (LOD) for HBsAg was estimated to be 12 pg/mL, representing over 10-fold higher sensitivity compared with commercially available HBsAg ELISA kits (LOD: 200 pg/mL). In addition, the fluorescence response toward porcine whole blood samples containing different HBsAg concentrations was also confirmed by capturing images with a smartphone, followed by quantitative data analysis. These results demonstrate the potential applicability of the proposed platform for clinical tests at the point of care.