ACS Sensors最新文献_第4页

Analysis of Multivariable Sensor Responses to Multi-Analyte Gas Samples in the Presence of Interferents and Humidity 分析存在干扰和湿度时传感器对多种分析气体样本的多变量响应

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c02200

Sakin Satter, Florian Bender, Nicholas Post, Antonio J. Ricco, Fabien Josse

This work presents an adaptive sensor signal-processing approach to enable quantification, using a single gas sensor or a small sensor array, of multianalyte mixtures of aromatic hydrocarbons in the presence of various interferents and humidity for environmental-monitoring applications. Dynamic sensor responses are analyzed by extracting multivariable sensing parameters to provide necessary sensitivity and selectivity. This is achieved by integrating the Levenberg–Marquardt-modified, exponentially weighted, recursive-least-squares-estimation (LM-modified EW-RLSE) algorithm and principal-component analysis (PCA). Achieving measured detection limits as low as 3 μg/L (≤1 ppm by volume) for 6 target analytes, the system exhibits excellent PCA cluster separation for all analytes in the mixtures, with reliable identification and accurate quantification, even in the presence of various interferents. Concentration errors of approximately ±5% are obtained for mixtures containing up to 6 BTEX compounds (including chemical isomers) and up to 4 interferents. Additionally, the study investigates the impact of humidity on the polymer/plasticizer-coated shear-horizontal surface acoustic wave (SH-SAW) sensors, demonstrating accurate concentration estimation in a relative humidity range from dry nitrogen to 65%. This sensing-and-multivariate-signal-processing approach is a promising candidate for reliable environmental monitoring in real-world applications.

这项研究提出了一种自适应传感器信号处理方法，可使用单个气体传感器或小型传感器阵列，对存在各种干扰和湿度的芳香烃多分析混合物进行定量，用于环境监测应用。通过提取多变量传感参数来分析传感器的动态响应，以提供必要的灵敏度和选择性。这是通过整合 Levenberg-Marquardt 修正、指数加权、递归最小二乘估计（LM 修正 EW-RLSE）算法和主成分分析（PCA）来实现的。该系统对 6 种目标分析物的检测限低至 3 μg/L（按体积计算≤1 ppm），对混合物中的所有分析物均表现出卓越的 PCA 簇分离能力，即使在存在各种干扰的情况下也能可靠地识别和准确定量。对于含有多达 6 种 BTEX 化合物（包括化学异构体）和多达 4 种干扰物的混合物，其浓度误差约为±5%。此外，该研究还调查了湿度对聚合物/增塑剂涂层剪切-水平表面声波 (SH-SAW) 传感器的影响，结果表明在干氮到 65% 的相对湿度范围内都能准确估计浓度。这种传感和多变量信号处理方法有望在实际应用中实现可靠的环境监测。

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引用次数: 0

Non-Destructive Pest Detection: Innovations and Challenges in Sensing Airborne Semiochemicals 非破坏性害虫探测：感知空气传播半生物化学物质的创新与挑战

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c02049

Ming Chen, Maryam Yazdani, Krishnan Murugappan

Pests, especially invasive ones, pose significant threats to the global ecosystem, crop security, and agriculture economy. Sensing airborne semiochemicals as a nondestructive detection method has been recognized as a promising strategy to detect the presence of these living pests on site. However, sensing airborne semiochemicals in fields is challenging, as they are transmitted in concentrations as low as several nanograms per cubic meter in chemically diverse environments. This low vapor pressure together with similarity in functional groups of pheromones among different species have curtailed the practical deployment of corresponding sensors for real world applications. This review describes the advances in semiochemical detection methods and technologies including traditional analytical instruments, trained animals, and electroantennography with a focus on electronic noses (e-noses). Several key types of volatile organic compound (VOC) sensors used in e-noses are summarized, including their transduction methods, sensing materials, and sensing performance for semiochemical and simulants detection. Notably, it was found that many commercial VOC sensors failed to respond to airborne semiochemicals effectively, leading to a reduced efficiency of e-noses. Future work may focus on developing stable and robust sensing materials with higher sensitivity and selectivity to pheromones and understanding the feasibility of the deployment of the sensors under field conditions.

害虫，尤其是入侵害虫，对全球生态系统、作物安全和农业经济构成了重大威胁。传感空气中的半化学物质作为一种无损检测方法，已被认为是检测现场是否存在这些活体害虫的一种有前途的策略。然而，在田间感应空气中的半化学物质具有挑战性，因为在化学性质不同的环境中，半化学物质的传播浓度低至每立方米几纳克。这种低蒸气压以及不同物种间信息素功能基团的相似性限制了相应传感器在现实世界中的实际应用。本综述介绍了半化学检测方法和技术的进展，包括传统的分析仪器、训练有素的动物和电子鼻（e-noses）等。综述了电子鼻中使用的几种主要的挥发性有机化合物 (VOC) 传感器，包括它们的传导方法、传感材料以及用于半化学和模拟物检测的传感性能。值得注意的是，研究发现许多商用挥发性有机化合物传感器无法对空气中的半化学物质做出有效反应，从而降低了电子鼻的效率。今后的工作重点可能是开发对信息素具有更高灵敏度和选择性的稳定而坚固的传感材料，并了解在现场条件下部署传感器的可行性。

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引用次数: 0

Dual Gold Nanostructures-Based Stretchable Electrochemiluminescence Sensors for Hydrogen Peroxide Monitoring in Endothelial Mechanotransduction 基于双金纳米结构的可拉伸电化学发光传感器用于监测内皮细胞机械传导中的过氧化氢

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c02421

Hao Liu, Qian Wang, Shi-Bo Cheng, Wei Mao, Lebao Mao, Xiuhua Zhang, Shengfu Wang, Wei-Hua Huang, Miao-Miao Chen

Hydrogen peroxide (H₂O₂) release during blood flow is commonly provoked by the cyclic stretch and dynamic shear stress of endothelial cells and is of vital significance for maintaining vascular function. Flexible and stretchable electrochemical sensors show great capability in retrieving mechanical stimulation-induced H₂O₂ variation; however, cell secretions, especially electroactive constituents’ interferences, remain a big concern for sensing accuracy. Herein, we developed a stretchable electrochemiluminescence (ECL) sensor by synthesizing L012-reduced gold nanospheres and decorating them onto a polydimethylsiloxane film-supported gold nanotubes substrate (Au NTs/PDMS) to form dual gold nanostructure-modified meshwork interface. Given the specific reaction between L012 and H₂O₂, the as-prepared Au-L012/Au NTs/PDMS exhibited outstanding selectivity toward H₂O₂ quantification. Through culturing human umbilical vein endothelial cells (HUVECs), real-time monitoring of transient H₂O₂ release from mechanically sensitive HUVECs in stretching states was realized. This work successfully incorporated the ECL sensing model into in situ cellular sensing, therefore expanding the application mode of the ECL approach for health care and biomedical investigation.

血流过程中的过氧化氢（H2O2）释放通常是由内皮细胞的循环拉伸和动态剪切应力引起的，对维持血管功能至关重要。柔性可拉伸电化学传感器在检索机械刺激引起的 H2O2 变化方面表现出很强的能力；然而，细胞分泌物，尤其是电活性成分的干扰，仍然是影响传感精度的一大问题。在此，我们合成了 L012 还原金纳米球，并将其装饰到聚二甲基硅氧烷薄膜支撑的金纳米管基底（Au NTs/PDMS）上，形成双金纳米结构修饰的网状界面，从而开发了一种可拉伸的电化学发光（ECL）传感器。鉴于 L012 与 H2O2 之间的特异性反应，制备的 Au-L012/Au NTs/PDMS 对 H2O2 的定量具有出色的选择性。通过培养人脐静脉内皮细胞（HUVEC），实现了对机械敏感的 HUVEC 在拉伸状态下瞬时释放 H2O2 的实时监测。这项工作成功地将ECL传感模型融入到原位细胞传感中，从而拓展了ECL方法在医疗保健和生物医学研究中的应用模式。

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引用次数: 0

Magnetoelastic Immunosensor for the Rapid Detection of SARS-CoV-2 in Bioaerosols 用于快速检测生物气溶胶中 SARS-CoV-2 的磁弹性免疫传感器

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c01749

Qiannan Wang, Yunmei Cao, Zhongyun Yuan, Mengshu Han, Yunxuan Zhang, Kai Zhuo, Lei Sun, Xing Guo, Hongpeng Zhang, Hu Jin

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a protein-coated, single-stranded RNA virus that parasitizes and infects primates, including humans. The current detection methods are mainly carried out using humans as a medium, such as a chest computed tomography (CT) examination, nucleic acid detection, antibody detection, and antigen detection. In addition, SARS-CoV-2 in bioaerosols is an important way of transmission and infection, which has attracted wide attention. In this paper, we simulate a sampling system of SARS-CoV-2 in bioaerosols and detect SARS-CoV-2 in bioaerosols by means of a magnetoelastic (ME) sensing device based on an Android intelligent terminal, which can directly detect SARS-CoV-2 in bioaerosols in a certain unit environment. This approach aims to achieve early detection and prevention. The experimental results show that the sampling system can successfully collect SARS-CoV-2 in bioaerosols. In the linear range of 5–20 ng/mL, the ME sensing detection system results closely match those of the calibration instrument (VNA), with goodness-of-fit values of 0.997 and 0.995, respectively. This work demonstrates that the ME sensing detection system proposed is stable, highly specific, real-time, rapid, and has certain reference values and feasibility.

严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）是一种蛋白包被的单链 RNA 病毒，寄生并感染包括人类在内的灵长类动物。目前的检测方法主要是以人作为媒介，如胸部计算机断层扫描（CT）检查、核酸检测、抗体检测和抗原检测等。此外，生物气溶胶中的 SARS-CoV-2 是一种重要的传播和感染途径，已引起广泛关注。本文模拟了生物气溶胶中SARS-CoV-2的采样系统，通过基于安卓智能终端的磁弹性（ME）传感装置检测生物气溶胶中的SARS-CoV-2，可在一定单位环境下直接检测生物气溶胶中的SARS-CoV-2。这种方法旨在实现早期检测和预防。实验结果表明，采样系统能够成功采集生物气溶胶中的 SARS-CoV-2 。在 5-20 ng/mL 的线性范围内，ME 传感检测系统的检测结果与校准仪器（VNA）的检测结果非常吻合，拟合度分别为 0.997 和 0.995。这项工作表明，所提出的 ME 传感检测系统稳定、特异性强、实时、快速，具有一定的参考价值和可行性。

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引用次数: 0

Hydrophobic and Elastic Structural Triboelectric Materials Enabled by Template Method toward Real-Time Material Recognition 通过模板法实现实时材料识别的疏水和弹性结构三电材料

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c01799

Junjun Huang, Yuting Zong, Kunhong Hu, Wenlong Chen, Yue Liu, Zhenming Chen, Honglin Li, Chengmei Gui

Since each material has a unique ability to lose or obtain electrons, specific triboelectric signals are produced when triboelectric materials are in contact with different objects. Triboelectric nanogenerator (TENG) devices show great potential for use as tactile sensors; nevertheless, analyzing the structure–function relationship of functionalized triboelectric sensing interfaces under environmental conditions and improving the sensing stability and accuracy through the design of hydrophobic structure on the triboelectric material surface remain major challenges in the development of intelligent sensing networks. Compared with the traditional rigid micronanostructure, the elastic micronanostructure strategy is applied to achieve both hydrophobicity and stability of triboelectric materials based on the template method in this work. The corresponding surface roughness and contact angle are 89.9 nm and 117.9°, respectively. As expected, the output voltage and charge density are enhanced by almost 65.8 and 33.4%, respectively, with the establishment of an elastic micronanostructure on the triboelectric material surface. More importantly, the triboelectric signal waveforms also present acceptable durability for subsequent recognition after immersion in water or ethanol for 12 days and metal impact for 12 000 cycles. Hence, combined with deep machine learning and triboelectric effect, a material perception system integrated with a moisture-resistant TENG-based sensor after fatigue testing, data processing, and display modules is also developed for real-time monitoring with approximately 100% (mask), 76% (plank), 93% (plastic), and 89% (rubber) identification accuracies in the natural environment. Finally, the proposed hydrophobic and elastic triboelectric materials show broad potential for application in the field of human–computer interaction.

由于每种材料都具有独特的失去或获得电子的能力，当三电材料与不同物体接触时，就会产生特定的三电信号。三电纳米发生器（TENG）器件在用作触觉传感器方面显示出巨大的潜力；然而，分析功能化三电传感界面在环境条件下的结构-功能关系，以及通过在三电材料表面设计疏水结构来提高传感稳定性和准确性，仍然是智能传感网络发展中的主要挑战。与传统的刚性微纳结构相比，本研究基于模板法，采用弹性微纳结构策略实现了三电材料的疏水性和稳定性。相应的表面粗糙度和接触角分别为 89.9 nm 和 117.9°。正如预期的那样，随着三电材料表面弹性微纳结构的建立，输出电压和电荷密度分别提高了近 65.8% 和 33.4%。更重要的是，在水或乙醇中浸泡 12 天和金属撞击 12 000 次后，三电信号波形在后续识别中也表现出了可接受的耐用性。因此，结合深度机器学习和三电效应，经过疲劳测试、数据处理和显示模块后，还开发出一种集成了基于 TENG 的防潮传感器的材料感知系统，用于在自然环境中进行实时监测，其识别准确率约为 100%（面具）、76%（木板）、93%（塑料）和 89%（橡胶）。最后，所提出的疏水和弹性三电材料在人机交互领域显示出了广泛的应用潜力。

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引用次数: 0

Whispering Gallery Mode Micro/Nanolasers for Intracellular Probing at Single Cell Resolution 用于单细胞分辨率细胞内探测的悄悄话画廊模式微型/氖激光器

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c01634

Yiqian Fu, Siqi Lin, Xiu-Hong Wang

Intracellular probing at single cell resolution is key to revealing the heterogeneity of cells, learning new cell subtypes and functions, understanding the pathophysiology of disease, and ensuring precise diagnosis and treatment. Despite the best efforts, an enormous challenge remains due to the very small size, extremely low content, and dynamic microenvironment of a single cell. Whispering gallery mode (WGM) micro/nanolasers (active WGM) offer unique advantages of small mode volume, high quality factors, bright and low threshold laser emission, and narrow line width, particularly suitable for integration within a single cell. In this review, we provide a focused overview of WGM micro/nanolasers for intracellular probing. We deliver information on WGM micro/nanolaser concepts, sensing mechanism, and biocompatibility, as well as recent progress in intracellular probing applications mainly covering cellular-level sensing, molecular-level detection, and feasibility for cellular imaging. At the end, challenges and prospects of WGM micro/nanolasers for intracellular applications are discussed.

单细胞分辨率的细胞内探测是揭示细胞异质性、了解新的细胞亚型和功能、理解疾病的病理生理学以及确保精确诊断和治疗的关键。尽管已经尽了最大努力，但由于单细胞体积极小、含量极低、微环境动态变化，因此仍然存在巨大的挑战。低语画廊模式（WGM）微型/激光器（有源 WGM）具有模式体积小、品质因数高、激光发射明亮且阈值低、线宽窄等独特优势，特别适合集成到单细胞内。在这篇综述中，我们重点概述了用于细胞内探测的 WGM 微型/纳米激光器。我们介绍了 WGM 微型/纳米激光器的概念、传感机制和生物相容性，以及细胞内探测应用的最新进展，主要包括细胞级传感、分子级检测和细胞成像的可行性。最后，讨论了 WGM 微型/纳米激光器在细胞内应用所面临的挑战和前景。

引用次数: 0

High-Performance Field-Effect Sensing of Ammonia Based on High-Density and Ultrathin Silicon Nanowire Channels 基于高密度超薄硅纳米线通道的高性能氨场效应传感技术

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-07 DOI: 10.1021/acssensors.4c02426

Chunsheng Yang, Wei Liao, Junzhuan Wang, Linwei Yu

Ultrathin silicon nanowires (SiNWs), grown via a high-yield and low-cost catalytic approach, are ideal building blocks for the construction of highly sensitive field-effect transistor (FET) sensors. In this work, we demonstrate a high-density growth integration of an ultrathin SiNW array, with diameter down to D_NW = 24 ± 3 nm and narrow NW-to-NW spacing of only 120 nm, fabricated via an in-plane solid–liquid–solid (IPSLS) approach. Junctionless bottom-gated SiNW FETs are successfully constructed, exhibiting a high on/off current ratio of >10⁷ and a sharp subthreshold swing of 156 mV/dec These provide an excellent platform for realizing high-performance NH₃ sensing at room temperature, with a high response of 96.9% at 25 ppm and 38.6% at 2.5 ppm, rapid response time of 7.9 s for 5% response (or 85.8 s for 50% response), and superior selectivity against common volatile organic compound gases in ambient environments. Finally, the field-effect sensing mechanism is attributed to the Schottky barrier modulation by the adsorbed NH₃ molecules at the metal/SiNW interface, as confirmed through an epoxy-masked selective region comparative analysis. These results provide a solid basis for the ultrathin catalytic IPSLS-SiNWs to serve as advantageous one-dimensional (1D) channels for the scalable integration of various high-performance and flexible gas sensing applications.

超细硅纳米线（SiNW）是通过高产出、低成本的催化方法生长出来的，是构建高灵敏度场效应晶体管（FET）传感器的理想构件。在这项工作中，我们展示了超薄 SiNW 阵列的高密度生长集成，其直径小至 DNW = 24 ± 3 nm，NW-NW 间距仅为 120 nm，通过面内固-液-固（IPSLS）方法制造而成。这些器件为在室温条件下实现高性能 NH3 传感提供了一个极佳的平台，在 25 ppm 和 2.5 ppm 条件下的响应分别高达 96.9% 和 38.6%，5% 响应的快速响应时间为 7.9 秒（50% 响应的快速响应时间为 85.8 秒），并且对环境中常见挥发性有机化合物气体具有卓越的选择性。最后，场效应传感机制归因于金属/SiNW 界面吸附的 NH3 分子对肖特基势垒的调制，这一点已通过环氧树脂掩膜选择性区域比较分析得到证实。这些结果为超薄催化 IPSLS-SiNWs 提供了坚实的基础，使其成为可扩展集成各种高性能和灵活气体传感应用的有利一维（1D）通道。

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引用次数: 0

Highly Sensitive and Biocompatible Microsensor for Selective Dynamic Monitoring of Dopamine in Rat Brain. 用于选择性动态监测大鼠脑内多巴胺的高灵敏度和生物相容性微传感器

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-06 DOI: 10.1021/acssensors.4c02109

Jiatao Chen, Fuyun Xia, Xiuting Ding, Dongdong Zhang

Highly selective and sensitive in vivo neurotransmitter dynamic monitoring of the central nervous system has long been a challenging endeavor. Here, an implantable and biocompatible microsensor with excellent performances was reported by electrodepositing poly(3,4-ethylenedioxythiophene)-electrochemically reduced graphene oxide (PEDOT-ERGO) nanocomposites and poly(tannic acid) (pTA) sequentially on the carbon fiber electrode (CFE) surface, and its feasibility in in vivo electrochemical sensing applications were demonstrated. Due to the synergistic electrocatalytic effect of PEDOT-ERGO nanocomposites with the negative-charged pTA on dopamine (DA) redox reaction, the microsensor exhibits high detection sensitivities of 1.1 and 0.37 nA μM^-1 in the detection ranges of 0.02-0.5 and 0.5-20 μM with a low limit of detection of 9.2 nM. Also, the microsensor shows excellent selectivity, good sensing stability, repeatability, and reproducibility. In addition, the highly hydrophilic and negative-charged pTA inhibits the nonspecific adsorption of hydrophobic proteins, which endows the microsensor with good antifouling ability. Moreover, DA dynamics in rat brain were successfully monitored in real time, and the selective sensing ability of the microsensor in vivo was also demonstrated. The present study provides a new method for selective dynamics monitoring of DA in the brain, which would help to better understand the pathological and physiological functions of DA.

长期以来，对中枢神经系统进行高选择性、高灵敏度的体内神经递质动态监测一直是一项具有挑战性的工作。本文通过在碳纤维电极（CFE）表面依次电沉积聚（3,4-乙烯二氧噻吩）-电化学还原氧化石墨烯（PEDOT-ERGO）纳米复合材料和聚（单宁酸）（pTA），报道了一种具有优异性能的植入式生物相容性微型传感器，并证明了其在体内电化学传感应用中的可行性。由于 PEDOT-ERGO 纳米复合材料与带负电荷的 pTA 对多巴胺（DA）氧化还原反应具有协同电催化作用，该微传感器在 0.02-0.5 和 0.5-20 μM 的检测范围内分别表现出 1.1 和 0.37 nA μM-1 的高检测灵敏度，检测限低至 9.2 nM。此外，该微型传感器还具有出色的选择性、良好的传感稳定性、重复性和再现性。此外，高亲水性和带负电荷的 pTA 可抑制疏水性蛋白质的非特异性吸附，从而使微传感器具有良好的防污能力。此外，该研究还成功地实时监测了大鼠大脑中的 DA 动态，并证明了该微传感器在体内的选择性传感能力。本研究提供了一种选择性动态监测脑内 DA 的新方法，有助于更好地了解 DA 的病理和生理功能。

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引用次数: 0

Nanorings Resembling Beehives for Ultrasensitive Fluorescence Detection 用于超灵敏荧光检测的蜂巢状纳米材料

IF 8.9 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-06 DOI: 10.1021/acssensors.4c02133

Chenglong Liao, Xiaozhen Che, Yanjun Gong, Hongwei Ji, Ling Zang, Yanke Che, Jincai Zhao

In this study, we showcase the fabrication of two nanorings resembling beehives using intricately designed donor–acceptor (D-A) fluorophores. The D–A fluorophores, featuring three twisted fluorene groups on each side of the acceptor group, adopt a bent conformation that promotes the creation of a nanoring morphology upon aggregation. With porosity for maximum binding sites, high emission efficiency, and well-organized arrangements, the nanoring-based hives offer exceptional sensitivity and selectivity in the detection of organic sulfides. Particularly, nanorings formed from benzselenodiazole-containing molecules exhibit heightened sensitivity, achieving a limit of detection (LOD) of 0.2 ppb for dimethyl sulfide and 17 ppb for dimethyl disulfide. Due to its unparalleled sensitivity and selectivity, which was not achievable with previous optical sensors, this technology enables the continuous monitoring of meat spoilage in its early stages on an hourly basis. This provides crucial insights into the exact moments when freshness begins to deteriorate and how long the meat can be stored for.

在这项研究中，我们展示了利用精心设计的供体-受体（D-A）荧光团制造出的两种类似蜂巢的纳米环。D-A 荧光团的特点是受体基团两侧各有三个扭曲的芴基团，采用弯曲构象，可在聚集后形成纳米环形态。这种基于纳米环的蜂巢具有多孔性，可提供最大的结合位点，发射效率高，排列有序，因此在检测有机硫化物时具有极高的灵敏度和选择性。特别是，由含苯并硒二唑分子形成的纳米环具有更高的灵敏度，二甲基硫醚的检测限（LOD）为 0.2 ppb，二甲基二硫化物的检测限（LOD）为 17 ppb。由于该技术具有以往光学传感器无法达到的无与伦比的灵敏度和选择性，因此可以每小时连续监测肉类腐败的早期阶段。这样就能准确了解肉类新鲜度开始变差的时间，以及肉类还能存放多久。

引用次数: 0

Decoding Insulin Secretory Granule Maturation Using Genetically Encoded pH Sensors. 利用基因编码的 pH 传感器解码胰岛素分泌颗粒的成熟过程

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors

Pub Date : 2024-11-06 DOI: 10.1021/acssensors.4c01885

Wen Lin, Kaylee Tseng, Scott E Fraser, Jason Junge, Kate L White

Insulin is a peptide hormone secreted from pancreatic beta cells to regulate blood glucose homeostasis. Maturation of active insulin occurs within insulin secretory granules (ISG) by acidification of the lumen and enzymatic cleavage of insulin before secretion. This process is dysregulated in diabetes, and many questions remain on how the cell controls insulin maturation. We address this gap in knowledge by designing two genetically encoded fluorescence pH sensors and a fluorescence lifetime imaging and analysis pipeline to monitor the pH of individual secretory ISGs within live cells at higher resolution and precision than previously possible. We observed different subpopulations of ISGs based on their pH and subcellular localization. Signals regulating metabolism vs membrane depolarization mobilize different subpopulations of ISGs for secretion, and we confirm that maturation signals acidify ISGs. We conclude that different signaling networks uniquely impact ISG mobilization and secretion. Future applications of these tools will be useful for exploring how these processes are dysregulated in diabetes and provide new paths for developing more effective treatments.

胰岛素是一种肽类激素，由胰腺β细胞分泌，用于调节血糖平衡。活性胰岛素的成熟是通过胰岛素分泌颗粒（ISG）内腔的酸化和胰岛素分泌前的酶裂解实现的。糖尿病患者的这一过程失调，细胞如何控制胰岛素成熟仍存在许多问题。针对这一知识空白，我们设计了两种基因编码的荧光 pH 传感器和荧光寿命成像与分析管道，以比以往更高的分辨率和精度监测活细胞内单个分泌型 ISG 的 pH 值。我们根据 ISGs 的 pH 值和亚细胞定位观察到了不同的亚群。调节新陈代谢和膜去极化的信号调动不同亚群的 ISGs 进行分泌，我们证实成熟信号会使 ISGs 酸化。我们的结论是，不同的信号网络会对 ISG 的动员和分泌产生独特的影响。这些工具的未来应用将有助于探索糖尿病患者的这些过程是如何失调的，并为开发更有效的治疗方法提供新的途径。

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引用次数: 0