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Wearable In Situ SERS Sensors Based on the Metal@MOF Particle-in-Cavity Model: Suitable for Detection of Multifarious Biomarkers in Different Biofluids of Humans. 基于Metal@MOF腔内粒子模型的可穿戴原位SERS传感器:适用于人体不同生物流体中多种生物标志物的检测。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-27 DOI: 10.1021/acssensors.5c04143
Hao Li,Chongfeng Cao,Fengcai Lei,Minghui Du,Xiaofei Zhao,Zhen Li,Chao Zhang,Yang Jiao,Jing Yu
Biofluids are ideal sample sources for wearable in situ surface-enhanced Raman scattering (IS-SERS) sensors due to their noninvasive collection. However, the limited spatial reach of conventional hot spots (HSs), coupled with the fluidic and biocomplex nature of biofluids, means that only a small portion of target analytes can be effectively captured inside the HSs. To overcome this, we propose a metal@MOF particle-in-cavity (MMPIC) detection model. This architecture enhances the cascade electric field, expanding and concentrating HSs within and around the MOF dielectric. The integration of conical nanocavities with nanoporous MOFs enables effective analyte confinement and enrichment within the MOF matrix as well, ensuring colocalization with HSs in the same microregion. Additionally, the molecular sieving and graded refractive index properties of the MMPIC structure provide strong resistance to interference from both biofluids and their components. Together, these features improve both the sensitivity and robustness of the model. As a proof of concept, a microfluidic patch and a smart mask were developed based on the MMPIC model, enabling precise quantification of biomarkers-such as pH, glucose, ammonia, and 4-ethylbenzaldehyde-down to 1 ppb in real human sweat and exhaled breath. This work introduces a universal wearable IS-SERS detection model and validates its applicability across diverse real-world scenarios, offering valuable guidance for future wearable in situ sensing technologies.
生物流体是可穿戴的原位表面增强拉曼散射(IS-SERS)传感器的理想样品来源,因为它们的非侵入性收集。然而,传统热点(HSs)的空间覆盖范围有限,加上生物流体的流体性和生物复杂性,意味着只有一小部分目标分析物可以在HSs内有效捕获。为了克服这个问题,我们提出了一个metal@MOF腔内粒子(MMPIC)检测模型。这种结构增强了级联电场,扩大和集中了MOF介电介质内部和周围的HSs。锥形纳米空腔与纳米多孔MOF的集成使得分析物在MOF基质内的有效限制和富集,确保了与HSs在同一微区域的共定位。此外,MMPIC结构的分子筛分和渐变折射率特性提供了强大的抵抗生物流体及其组分干扰的能力。这些特征共同提高了模型的灵敏度和鲁棒性。作为概念验证,基于MMPIC模型开发了微流控贴片和智能口罩,能够精确定量生物标志物,如pH值,葡萄糖,氨和4-乙基苯甲醛,在真实的人体汗液和呼出气体中低至1 ppb。本工作介绍了一种通用的可穿戴IS-SERS检测模型,并验证了其在不同现实场景中的适用性,为未来可穿戴原位传感技术提供了有价值的指导。
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引用次数: 0
Optimizing the Stability of Co3O4 for Acetone Sensing by Oxygen Vacancy Alteration 氧空位改变优化Co3O4对丙酮传感的稳定性
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-27 DOI: 10.1021/acssensors.5c03258
Sihao Zhi, Liang Zhao, Yunpeng Xing, Hongda Zhang, Chengchao Yu, Teng Fei, Sen Liu, Haiyan Zhang, Tong Zhang
An increase in surface-adsorbed oxygen species presents unique opportunities to improve the sensing performance of metal oxide-based gas sensors. However, the instability of surface-adsorbed oxygen species, especially in the gas sensing process, decreases the sensing performance. This study reveals the performance‒stability paradox of surface-adsorbed oxygen species for Co3O4-based acetone sensors. A hydrothermal synthesis method assisted by P123 was used to prepare Co3O4 with an appropriate surface-adsorbed oxygen species (designated as Co3O4-AP). Unlike Co3O4 with less surface-adsorbed oxygen species, as-prepared Co3O4-AP exhibited a high response value of 19.0 (100 ppm acetone) on the first day but decreased to 13.9 on the seventh day, with a relative standard deviation of 15.7% in terms of resistance and 15.0% in terms of response values, respectively, owing to the loss of surface-adsorbed oxygen species during the sensing process (mainly the filling of oxygen vacancies by O2). Owing to the instability of surface-adsorbed oxygen species, aging at 240 °C in air for 2 days was rationally performed for Co3O4-AP, decreasing the surface-adsorbed oxygen species concentration and improving the stability of Co3O4-AP. Notably, after aging for 2 days, the Co3O4-AP sensor achieves a response value of 12.9 (100 ppm acetone), high selectivity, and good stability (relative standard deviations of 7.0 and 9.1% in terms of resistance and response values, respectively), outperforming acetone sensors based on Co3O4 obtained by hydrothermal synthesis without P123 (7.2), the coprecipitation method (7.6), and the direct calcination method (3.5). Our work provides new insights into overcoming the performance‒stability trade-off and designing highly stable and high-performing gas sensors.
表面吸附氧的增加为提高金属氧化物气体传感器的传感性能提供了独特的机会。然而,表面吸附氧的不稳定性,特别是在气体传感过程中,降低了传感性能。该研究揭示了co3o4基丙酮传感器表面吸附氧的性能稳定性悖论。采用P123辅助水热合成的方法,用合适的表面吸附氧(Co3O4- ap)制备了Co3O4。与表面吸附氧较少的Co3O4不同,制备的Co3O4- ap在第一天的响应值很高,为19.0 (100 ppm丙酮),但在第7天的响应值下降到13.9,电阻和响应值的相对标准差分别为15.7%和15.0%,这是由于在传感过程中(主要是氧气空位被O2填充)表面吸附氧的损失。由于Co3O4-AP表面吸附氧的不稳定性,合理的对Co3O4-AP进行240℃空气时效2天,降低了表面吸附氧的浓度,提高了Co3O4-AP的稳定性。值得注意的是,老化2天后,Co3O4- ap传感器的响应值为12.9 (100 ppm丙酮),选择性高,稳定性好(电阻和响应值的相对标准偏差分别为7.0和9.1%),优于无P123水热合成的Co3O4丙酮传感器(7.2)、共沉淀法(7.6)和直接煅烧法(3.5)。我们的工作为克服性能稳定性权衡和设计高稳定性和高性能气体传感器提供了新的见解。
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引用次数: 0
Compact Differential Photoacoustic Exhaled Gas Sensor for Online ETCO2 and ETO2 Monitoring 用于在线ETCO2和etto2监测的紧凑差分光声呼出气体传感器
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-27 DOI: 10.1021/acssensors.5c03835
Xukun Yin, Chenchen Zhu, Xiu Yang, Lei Liu, Dacheng Zhang, Kaijie Xu, Hongzhi Wang, Shuangping Zhang, Nicoletta Ardito, Pietro Patimisco, Angelo Sampaolo, Vincenzo Spagnolo, Hongpeng Wu, Huailiang Xu
Online exhaled breath analysis holds great promise for noninvasive medical diagnostics, health monitoring, and environmental exposure assessment. However, the complex nature of the breath matrix and strong interference from water vapor and carbon dioxide make high-precision, real-time sensing challenging, often requiring large and costly systems such as mass spectrometers. In this work, we present a compact differential photoacoustic gas sensor for end-tidal carbon dioxide (ETCO2) and end-tidal oxygen (ETO2) monitoring. The sensor employs a dual-resonator photoacoustic cell with resonant frequencies of 4110 and 13,115 Hz for selective ETCO2 and ETO2 detection, respectively. A small sample gas volume of 2.6 mL enables a rapid response time of <0.5 s, enabling rapid tracking of changes in exhaled gas concentration. The optimized system achieves detection limits of 12.6 ppm for CO2 and 18.4 ppm for O2, with corresponding normalized noise equivalent absorption values of 2.9 × 10−8 and 1.6 × 10−7 cm−1⋅W⋅Hz−1/2. Real-time monitoring during human respiration demonstrates clear tracking of physiological O2 depletion and CO2 enrichment, consistent with respiratory dynamics. The developed sensor combines high sensitivity, fast response, compact size, and low cost, showing strong potential for continuous clinical monitoring, perioperative care, and metabolic studies.
在线呼气分析在无创医疗诊断、健康监测和环境暴露评估方面有着巨大的前景。然而,呼吸矩阵的复杂性和水汽和二氧化碳的强烈干扰使得高精度、实时传感具有挑战性,通常需要大型和昂贵的系统,如质谱仪。在这项工作中,我们提出了一种紧凑的差分光声气体传感器,用于监测潮末二氧化碳(ETCO2)和潮末氧气(ETO2)。该传感器采用双谐振腔光声电池,谐振频率为4110 Hz和13115 Hz,分别用于选择性检测ETCO2和ETO2。2.6 mL的小样本量可实现0.5 s的快速响应时间,可快速跟踪呼出气体浓度的变化。优化后的系统对CO2和O2的检出限分别为12.6 ppm和18.4 ppm,相应的归一化噪声等效吸收值分别为2.9 × 10−8和1.6 × 10−7 cm−1⋅W⋅Hz−1/2。人体呼吸过程的实时监测显示出清晰的生理O2消耗和CO2富集跟踪,与呼吸动力学一致。该传感器具有灵敏度高、反应快、体积小、成本低等特点,在临床连续监测、围手术期护理和代谢研究方面具有很强的潜力。
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引用次数: 0
Interface-Engineered Janus Au@CeO2 Nanostructures for Ultrasensitive Ratiometric SERS Platforms. 界面工程Janus Au@CeO2纳米结构用于超灵敏比率SERS平台。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-27 DOI: 10.1021/acssensors.5c03379
Lulu Tian,Songtao Hu,Qihang Ding,Zhenyu Ma,Cong Chen,Chunyan Li,Kun Wang,Juanrui Du,Yujia Shi,Jong Seung Kim,Lin Wang,Biao Dong
Monolayer noble metal nanoparticle (NP) arrays hold great promise as surface-enhanced Raman scattering (SERS) substrates due to their strong SERS performance and cost-effectiveness. However, precise regulation of hotspot intensity and density remains a critical challenge for practical applications. Here, we propose a SERS substrate based on Janus-structure NPs, which realizes accessible metal-semiconductor interface hotspots, as well as the regulation of interparticle nanogaps of ∼1 nm through a multifunctional surface ligand. By selectively depositing cerium oxide (CeO2) onto one terminus of gold nanorods (Au NRs), we fabricate Janus nanostructures that generate highly accessible and intensified hotspots. Another key enabler of this advancement is 4-mercaptophenylboronic acid (MPBA), a multifunctional ligand that precisely regulates interparticle spacing, increases hotspot density, and simultaneously serves as both a Raman molecule and a bacterial recognition unit. The SERS enhancement effect of the Janus NP array can reach more than 11 times that of the conventional Au NR array. Based on this MPBA-functionalized Janus NP array substrate, a SERS sensor for Escherichia coli was constructed, which exhibited a robust linear detection response to bacterial concentrations ranging from 6 to 6 × 104 CFU/μL, with an ultralow detection limit of approximately 1.1 CFU/μL. Our work introduces a versatile strategy for next-generation SERS substrates.
单层贵金属纳米颗粒(NP)阵列由于其强大的SERS性能和成本效益,作为表面增强拉曼散射(SERS)衬底具有很大的前景。然而,热点强度和密度的精确调节仍然是实际应用的关键挑战。在这里,我们提出了一种基于janus结构NPs的SERS衬底,它实现了可访问的金属-半导体界面热点,并通过多功能表面配体调节颗粒间约1 nm的纳米间隙。通过选择性地将氧化铈(CeO2)沉积在金纳米棒(Au NRs)的一端,我们制造出了Janus纳米结构,该结构可以产生高度可接近和强化的热点。这一进展的另一个关键促成因素是4-巯基苯基硼酸(MPBA),这是一种多功能配体,可以精确调节颗粒间距,增加热点密度,同时作为拉曼分子和细菌识别单元。Janus NP阵列的SERS增强效果可以达到传统Au NR阵列的11倍以上。基于该mpba功能化的Janus NP阵列底物,构建了大肠杆菌SERS传感器,该传感器对细菌浓度在6 ~ 6 × 104 CFU/μL范围内具有良好的线性检测响应,超低检出限约为1.1 CFU/μL。我们的工作介绍了下一代SERS基板的通用策略。
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引用次数: 0
An Extraction-free One-Pot Assay for Rapid Field Discrimination of African Swine Fever Virus Variants by a Single-Step RPA-CRISPR/Cas12a Strategy. 基于单步RPA-CRISPR/Cas12a策略的非洲猪瘟病毒变体快速田间鉴定无提取单锅试验
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-27 DOI: 10.1021/acssensors.5c03287
Wenyan Li,Yunpeng Yang,Wenyi Xu,Yongchong Zhu,Yue Li,Lihui Cao,Shuyao Lyu,Jingqun Liu,Yan Xie,Xueping Li,Xianghua Hu,Lizhen Huang
African swine fever virus (ASFV) causes devastating outbreaks in swine populations worldwide. The co-existence of wild-type and emerging gene-deleted variants (e.g., ASFV-ΔI177L) necessitates rapid on-site diagnostic tools for strain identification, which is critical for timely disease control and tailored farm management. Here, we developed a field-deployable, extraction-free one-pot assay (CORDSv2) that combines multiplex RPA and CRISPR/Cas12a to target conserved ASFV sequences and specific fluorescent markers (eGFP/mCherry) of gene-deleted variants. The assay achieved ultrasensitive detection (LOD: 6 copies/μL) and demonstrated 97.9% accuracy with 96 field samples. To streamline field operations, we integrated an extraction-free protocol (for serum/saliva) with freeze-dried reagent microspheres, enabling stable storage and direct use with minimal manual handling. When paired with a portable fluorometer (hippoCORDS), the system completes the entire sample-to-answer workflow within 1 h with a single step: addition of lysate to the microspheres. This robust, portable system addresses the urgent need for simple, on-site ASFV variant surveillance and is adaptable for other high-threat pathogens.
非洲猪瘟病毒(ASFV)在世界范围内的猪群中引起毁灭性的暴发。野生型和新出现的基因缺失变异(例如ASFV-ΔI177L)的共存需要快速的现场诊断工具来进行菌株鉴定,这对于及时控制疾病和量身定制的农场管理至关重要。在这里,我们开发了一种可现场部署的,无需提取的单锅试验(CORDSv2),该试验结合了多重RPA和CRISPR/Cas12a来靶向保守的ASFV序列和基因缺失变体的特定荧光标记(eGFP/mCherry)。该方法对96份现场样品的检测精度达到97.9% (LOD: 6 copies/μL)。为了简化现场操作,我们将无提取方案(用于血清/唾液)与冻干试剂微球集成在一起,实现稳定的存储和直接使用,只需最少的人工处理。当与便携式荧光计(hippocord)配对时,该系统在1小时内完成整个从样品到答案的工作流程,只需一步:将裂解液添加到微球中。这一强大、便携的系统满足了简单、现场监测非洲猪瘟变异体的迫切需求,并适用于其他高威胁病原体。
{"title":"An Extraction-free One-Pot Assay for Rapid Field Discrimination of African Swine Fever Virus Variants by a Single-Step RPA-CRISPR/Cas12a Strategy.","authors":"Wenyan Li,Yunpeng Yang,Wenyi Xu,Yongchong Zhu,Yue Li,Lihui Cao,Shuyao Lyu,Jingqun Liu,Yan Xie,Xueping Li,Xianghua Hu,Lizhen Huang","doi":"10.1021/acssensors.5c03287","DOIUrl":"https://doi.org/10.1021/acssensors.5c03287","url":null,"abstract":"African swine fever virus (ASFV) causes devastating outbreaks in swine populations worldwide. The co-existence of wild-type and emerging gene-deleted variants (e.g., ASFV-ΔI177L) necessitates rapid on-site diagnostic tools for strain identification, which is critical for timely disease control and tailored farm management. Here, we developed a field-deployable, extraction-free one-pot assay (CORDSv2) that combines multiplex RPA and CRISPR/Cas12a to target conserved ASFV sequences and specific fluorescent markers (eGFP/mCherry) of gene-deleted variants. The assay achieved ultrasensitive detection (LOD: 6 copies/μL) and demonstrated 97.9% accuracy with 96 field samples. To streamline field operations, we integrated an extraction-free protocol (for serum/saliva) with freeze-dried reagent microspheres, enabling stable storage and direct use with minimal manual handling. When paired with a portable fluorometer (hippoCORDS), the system completes the entire sample-to-answer workflow within 1 h with a single step: addition of lysate to the microspheres. This robust, portable system addresses the urgent need for simple, on-site ASFV variant surveillance and is adaptable for other high-threat pathogens.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"110 1","pages":"XXX"},"PeriodicalIF":8.9,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Click Egg Safety Check: A Syringe-Integrated Portable Platform for On-Site Fluoroquinolone Residue Detection. 一键式鸡蛋安全检查:一种现场检测氟喹诺酮类药物残留的注射器集成便携式平台。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-22 DOI: 10.1021/acssensors.5c03192
Yingying Feng,Wanqi Jiang,Wenya Liu,Yuqing Zhang,Xiyao Liang,Shuqing Mei,Kai Wang,Yaqing Xiao,Yingnan Liu
A portable integrated sensing device incorporating a Tb3+/DTE-Cu NC ratiometric fluorescent probe was developed for the rapid on-site detection of fluoroquinolone (FQ) residues in poultry eggs. The system features a dual-layer filtration unit, consisting of glass wool and a polyvinyl alcohol/sodium alginate hydrogel, which purifies egg samples in situ through combined physical interception and chemical adsorption. The Tb3+/DTE-Cu NC probe was immobilized within the hydrogel matrix, enabling full integration of the entire "sample introduction-filtration-detection" process. Under 365 nm UV light, fluorescence emission shifts from red to green as the FQ concentration increases. Quantitative analysis is accomplished by extracting the G/R ratio from smartphone-captured RGB values. The device achieves a detection limit of 1.6 nM, with recoveries for spiked egg samples ranging from 91% to 112%. This low-cost, rapid, and instrument-free platform presents a practical solution for the sensitive on-site monitoring of antibiotic residues in food safety applications.
研制了一种便携式Tb3+/DTE-Cu NC比例荧光探针集成传感装置,用于禽蛋中氟喹诺酮(FQ)残留的快速现场检测。该系统采用双层过滤单元,由玻璃棉和聚乙烯醇/海藻酸钠水凝胶组成,通过物理拦截和化学吸附相结合的方式对鸡蛋样品进行原位净化。Tb3+/DTE-Cu NC探针固定在水凝胶基质内,实现了整个“样品导入-过滤-检测”过程的完全集成。在365 nm紫外光下,随着FQ浓度的增加,荧光发射由红色向绿色转变。定量分析是通过从智能手机捕获的RGB值中提取G/R比率来完成的。该装置的检出限为1.6 nM,加标鸡蛋样品的回收率为91% ~ 112%。这种低成本、快速、无仪器的平台为食品安全应用中抗生素残留的敏感现场监测提供了一种实用的解决方案。
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引用次数: 0
Phosphonic Acid-Anchored Tungsten Oxide Nanowire with Boosted Activity and Stability for Ammonia Sensing. 磷酸锚定氧化钨纳米线与提高活性和稳定性的氨传感。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-22 DOI: 10.1021/acssensors.5c02217
Ke Chen,Guozhu Zhang,Rui Gao,Jiangfei Shi,Chao Zhang,Zeyu Wang,Kun Qian,Kazuki Nagashima,Yang Gao,Fu-Zhen Xuan
Highly active and stable sensing surfaces are critical for the integration of catalysis-based electrical gas molecular sensors. However, achieving both high sensitivity and durability remains a persistent challenge due to continuous exposure to target molecules often results in surface deactivation and sensing performance degradation. Herein, we demonstrate a robust surface functionalization strategy to simultaneously enhance sensitivity and long-term stability for ammonia (NH3) detection by modifying hexagonal tungsten oxide (h-WO3) nanowires with methylphosphonic acid (MPA). Fourier-transform infrared spectroscopy (FTIR) and density functional theory (DFT) calculations reveal that phosphate groups in MPA selectively bind to the Lewis acid sites (undercoordinated W6+) on h-WO3 nanowires, effectively passivating the surface and mitigating degradation. Concurrently, the electron-rich P=O moiety facilitates strong interaction with NH3 molecules, leading to enhanced chemisorption and signal transduction. As a result, MPA-functionalized h-WO3 nanowire sensors exhibit a nearly tenfold increase in NH3 sensitivity compared to the unmodified h-WO3 sensors and maintain stable performance over 300 days of continuous operation. As a proof of concept for applied scenarios, we integrate the modified sensors into a microelectromechanical system (MEMS)-based smart ventilation system, enabling real-time NH3 monitoring and control in livestock environments. This work presents a viable route for designing high-performance, durable gas sensors through targeted molecular surface engineering.
高活性和稳定的传感表面对于基于催化的电气体分子传感器的集成至关重要。然而,实现高灵敏度和耐久性仍然是一个持续的挑战,因为持续暴露于目标分子通常会导致表面失活和传感性能下降。在此,我们展示了一种强大的表面功能化策略,通过甲基膦酸(MPA)修饰六方氧化钨(h-WO3)纳米线,同时提高了氨(NH3)检测的灵敏度和长期稳定性。傅里叶变换红外光谱(FTIR)和密度泛函数理论(DFT)计算表明,MPA中的磷酸基团选择性地结合h-WO3纳米线上的Lewis酸位点(低配位W6+),有效地钝化表面并减轻降解。同时,富含电子的P=O部分促进了与NH3分子的强相互作用,从而增强了化学吸附和信号转导。结果表明,与未经改性的h-WO3传感器相比,mpa功能化的h-WO3纳米线传感器对NH3的灵敏度提高了近10倍,并且在连续运行300天的时间内保持稳定的性能。作为应用场景的概念验证,我们将改进的传感器集成到基于微机电系统(MEMS)的智能通风系统中,实现牲畜环境中NH3的实时监测和控制。这项工作为通过靶向分子表面工程设计高性能、耐用的气体传感器提供了一条可行的途径。
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引用次数: 0
Charge-Transfer-Driven Enantioselective Surface-Enhanced Raman Scattering on a ZIF-8/ZnS Heterojunction: A Chiral-Label-Free Biosensor for Quantification of Urinary Lactate Enantiomeric Excess. 电荷转移驱动的ZIF-8/ZnS异质结表面增强拉曼散射:一种用于定量尿乳酸对映体过量的无手性标记生物传感器。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-22 DOI: 10.1021/acssensors.5c03836
Shaorui Qi,Lei Sun,Fansheng Meng,Guimei Shi,Yunlong Sun,Bo Jiang,Junbo Li,Yukihiro Ozaki,Wei Ji
Abnormal lactic acid (LA) enantiomeric excess (ee) in biofluids is closely associated with various intestinal diseases. Here, we report a chiral-label-free nonplasmonic surface-enhanced Raman scattering (SERS) platform using a ZIF-8/ZnS heterojunction that enables direct quantification of LA enantiomers and their ee values in raw human urine through a charge-transfer-driven chiral recognition mechanism. Our findings indicate that an enantioselective hydrogen bonding between 4-mercaptopyridine (4-MPy) probes and LA enantiomers induces differential charge-transfer effects within the ZIF-8/ZnS@4-MPy system, evidenced by the selective enhancement of specific vibrational modes in the SERS spectra of 4-MPy and enantiomer-specific changes in the fluorescence lifetime of ZnS. This innovative system integrates signal amplification and stereoselectivity without the use of noble metals or chiral modifiers, overcoming critical limitations associated with the complexity of preparing chiral plasmonic substrates. The platform achieves ultrasensitive detection limits (10 nM), linear response to ee values (R2 = 0.98), high measurement precision (RSD < 8.28%, n = 20), long-term stability (28-day), and clinical-grade accuracy against enzymatic assays (RMSEP = 1.97). This work presents an efficient, noninvasive method for the analysis of chiral metabolites in urine, while establishing a novel direction for plasmon-free SERS chiral sensing.
生物体液中乳酸(LA)对映体过量(ee)与多种肠道疾病密切相关。在这里,我们报告了一个使用ZIF-8/ZnS异质结的无手性标记的非等离子体表面增强拉曼散射(SERS)平台,该平台能够通过电荷转移驱动的手性识别机制直接量化原始人类尿液中的LA对映体及其ee值。我们的研究结果表明,4-巯基吡啶(4-MPy)探针和LA对映异构体之间的对映选择性氢键在ZIF-8/ZnS@4-MPy体系中诱导了不同的电荷转移效应,这可以通过4-MPy SERS光谱中特定振动模式的选择性增强和ZnS对映异构体荧光寿命的特异性变化来证明。这种创新的系统集成了信号放大和立体选择性,而不使用贵金属或手性修饰剂,克服了与制备手性等离子基板的复杂性相关的关键限制。该平台具有超灵敏的检测限(10 nM)、对ee值的线性响应(R2 = 0.98)、高测量精度(RSD < 8.28%, n = 20)、长期稳定性(28天)和对酶分析的临床级准确度(RMSEP = 1.97)。本研究提出了一种高效、无创的分析尿液中手性代谢物的方法,同时为无等离子体SERS手性传感开辟了新的方向。
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引用次数: 0
Self-Metered and Uniform Droplet Deposition within Defined Areas for Quantitative Surface-Enhanced Raman Scattering Detection. 定量表面增强拉曼散射检测的自测量和均匀液滴沉积。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-22 DOI: 10.1021/acssensors.5c04445
Zhilin Feng,Zhenle Qin,Xiaohui Fang,Yang Li,He Ma,Xinping Zhang
Achieving quantitative and reproducible surface-enhanced Raman scattering (SERS) detection remains challenging due to the stochastic nature of molecular distribution and the nonuniform enhancement of localized plasmonic "hot spots". Here, we present a wettability-patterned Ag nanoparticles and ZnO nanorod (Ag/ZnO)-nanostructured substrate that enables self-metered droplet partitioning and uniform molecular deposition for quantitative SERS sensing. By exploiting the strong contrast between hydrophilic and hydrophobic regions, a bulk liquid droplet can spontaneously split into an array of equal-volume microdroplets without any external confinement. During evaporation, the hydrophilic Ag/ZnO nanocolumns induce capillary-driven infiltration, which, in combination with wettability confinement, effectively suppresses the coffee ring effect and ensures homogeneous solute deposition within a defined area. Systematic comparisons among hydrophilic, flat-patterned, and nanostructured-patterned substrates reveal distinct drying dynamics, confirming that the synergistic control of capillary infiltration and wettability patterning governs uniform analyte distribution. Consequently, the designed substrate delivers highly linear and reproducible (RSD < 5%) SERS responses across multiple domains and analyte types. This simple yet robust self-metered droplet strategy provides a practical route toward uniform, quantitative, and molecule-independent SERS detection, offering new opportunities for reliable chemical and biosensing applications.
由于分子分布的随机性和局部等离子体“热点”的不均匀增强,实现定量和可重复的表面增强拉曼散射(SERS)检测仍然具有挑战性。在这里,我们提出了一种润湿性图案的银纳米颗粒和ZnO纳米棒(Ag/ZnO)纳米结构的衬底,可以实现自计液滴分配和均匀的分子沉积,用于定量SERS传感。通过利用亲水性和疏水性区域之间的强烈对比,大液滴可以在没有任何外部限制的情况下自发地分裂成等体积的微液滴阵列。在蒸发过程中,亲水的Ag/ZnO纳米柱诱导毛细管驱动的渗透,与润湿性约束相结合,有效抑制咖啡环效应,确保在限定区域内均匀的溶质沉积。系统比较亲水、平面和纳米结构基底揭示了不同的干燥动力学,证实了毛细渗透和润湿性模式的协同控制控制了分析物的均匀分布。因此,设计的底物在多个区域和分析物类型中提供高度线性和可重复性(RSD < 5%)的SERS响应。这种简单而强大的自测量液滴策略为均匀,定量和分子无关的SERS检测提供了实用途径,为可靠的化学和生物传感应用提供了新的机会。
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引用次数: 0
Performance Optimization of Semiconductor Gas Sensors Based on Interfacial Reaction Regulation: Status and Challenges. 基于界面反应调节的半导体气体传感器性能优化:现状与挑战。
IF 8.9 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-01-21 DOI: 10.1021/acssensors.5c02681
Xinyi Dai,Yuting Zhu,Sibo Zhang,Pengfei Sun,Xiaoping Dong,Fan Dong,Si Chen
Semiconductor gas sensors are widely used in environmental monitoring, industrial safety, etc., yet their performance is often hindered by issues such as cross-response, poor stability, and low sensitivity. Given the material-dependent nature of these limitations, the targeted optimization of the sensing properties remains a core challenge in the field. Gas sensing primarily involves adsorption and surface reactions, with performance critically governed by interfacial reaction kinetics at the gas-semiconductor interface. A deep understanding and precise modulation of these interfacial mechanisms are therefore essential for performance enhancement. This review systematically discusses how interfacial reactions influence key sensing parameters, including sensitivity, selectivity, stability, and dynamic response. Strategies for regulating these interfacial processes are analyzed to inform the rational design of high-performance sensors. Additionally, state-of-the-art characterization techniques and theoretical approaches for probing interfacial mechanisms are summarized, offering technical support for elucidating microscopic reaction pathways. By integrating current advances and challenges, this review establishes the fundamental links between material properties, interfacial chemistry, and sensing behavior, thereby providing a theoretical framework and design guidance for the next-generation semiconductor gas sensors.
半导体气体传感器广泛应用于环境监测、工业安全等领域,但其性能经常受到交叉响应、稳定性差、灵敏度低等问题的制约。考虑到这些限制的材料依赖性,有针对性地优化传感性能仍然是该领域的核心挑战。气体传感主要涉及吸附和表面反应,其性能关键取决于气体-半导体界面的界面反应动力学。因此,对这些界面机制的深入理解和精确调制对于提高性能至关重要。本文系统地讨论了界面反应如何影响关键的传感参数,包括灵敏度、选择性、稳定性和动态响应。分析了调节这些界面过程的策略,为高性能传感器的合理设计提供了依据。此外,总结了最新的表征技术和探索界面机制的理论方法,为阐明微观反应途径提供了技术支持。通过整合目前的进展和挑战,本文建立了材料特性、界面化学和传感行为之间的基本联系,从而为下一代半导体气体传感器提供了理论框架和设计指导。
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ACS Sensors
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