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Molecular Docking Studies of Potential Multifloroside and Trimyristin as Inhibitor for Anti Malaria 多花苷与Trimyristin抗疟疾抑制剂的分子对接研究
N. D. Malau, S. F. Azzahra
This study aims to analyze the potential of Multifloroside and Trimyristin as inhibitors of plasmepsin compounds as anti-malaria. The method used in analyzing the potential of Multifloroside and Trimyristin ligands as antimalarials is by insilico approach through tethering using Autodock Vina. Based on the free energy parameters of the Multifloroside molecular tethering, a value of -9.0 was obtained and for the Trimyristin molecule a value of -6.4 was obtained with 5 replications each. The free energy value of Multifloroside and Trimyristin ligands is negative, this means that Multifloroside and Trimyristin ligands are stable for use as Plasmepsin inhibitors. Because the lower the free energy of a molecule, the more stable the molecule is. But if you see the most potential between Multifloroside and Trimyristin, Multifloroside is better than Trimyristin ligands. Analysis based on hydrogen bonding parameters contained 1 hydrogen bond each showed that the stronger the Multifloroside and Trimyristin inhibitors bind to the receptors. For the Multifloroside ligand, the hydrogen bond formed is UNK-H ligand, whereas for Trimyristin ligand, the hydrogen bond formed is SER218-HN residue. The small number of hydrogen bonds does not affect the stability of the ligand and receptor bonds.
本研究旨在分析多花苷和Trimyristin作为plasmepsin化合物抑制剂的抗疟疾潜力。本研究采用Autodock Vina技术,通过体外链结的方法分析了多花苷和Trimyristin配体作为抗疟药物的潜力。根据多花苷分子拴系的自由能参数,得到-9.0,Trimyristin分子拴系的自由能参数为-6.4,每个重复5次。Multifloroside和Trimyristin配体的自由能值为负,这意味着Multifloroside和Trimyristin配体作为Plasmepsin抑制剂是稳定的。因为一个分子的自由能越低,它就越稳定。但如果你看到多萝西苷和三叶草素之间最大的潜力,多萝西苷比三叶草素配体更好。基于各含1个氢键的氢键参数分析表明,多花苷和Trimyristin抑制剂与受体的结合越强。对于多花苷配体,形成的氢键是UNK-H配体,而对于Trimyristin配体,形成的氢键是SER218-HN残基。少量的氢键不影响配体和受体键的稳定性。
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引用次数: 0
Students’ Creativity in Producing Biology Learning Media 学生在生物学习媒介制作中的创造力
F. Adinugraha
As prospective teachers of Biology, students have to acquire appropriate competencies of being good teachers. The competencies must be supported by their creativity, which can be developed by doing some projects in their learning process through producing Biology learning media. The students in this article are pre-service teachers of Biology Education who are studying in the university. This article presents some descriptions of Biology learning media, which were created by the students in the form of spinning fauna in Indonesia, biosumpit cells, plantae quick responses, digestive system scrapbook, biology ladder snakes, virus question boards, female reproductive system, bio minilab, and human skin display. Through experimental study by one-shot case study, this article describes the level of students’ creativity in creating the media as their final scores for Biology learning media project, which is in a good category with an average of 88.44; 17% (very good category) and 83% (good category). The students’ creativity in producing Biology learning media is also in a high category with an average of 2.66; 28% (fair categories) and 72% (high categories). Therefore, the students’ creativity which was supported by students and teachers in this study obtains the excellent final projects for Biology learning media.
作为未来的生物教师,学生必须具备成为一名好教师的相应能力。这些能力必须由他们的创造力来支撑,创造力可以通过制作生物学学习媒体在他们的学习过程中做一些项目来发展。本文的研究对象为在校生物教育专业的职前教师。这篇文章介绍了一些由学生制作的生物学习媒介,包括印度尼西亚的旋转动物、生物顶点细胞、植物快速反应、消化系统剪贴簿、生物阶梯蛇、病毒问题板、女性生殖系统、生物微型实验室和人体皮肤展示。通过一次性案例研究的实验研究,本文将学生在媒体创作方面的创造力水平描述为他们在生物学习媒体项目中的最终得分,平均得分为88.44分,属于良好类别;17%(非常好类别)和83%(好类别)。学生在制作生物学习媒体方面的创造力也处于较高水平,平均为2.66;28%(一般类别)和72%(高类别)。因此,学生的创造力在本研究中得到了学生和老师的支持,获得了生物学学习媒体的优秀期末项目。
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引用次数: 0
A Deferred Meaning of Home in Claude McKay’s Novel Home to Harlem 克劳德·麦凯小说《哈莱姆之家》中家的延后意义
Mike Wijaya Saragih
Taking a title of his first novel Home to Harlem (1928), Claude McKay as the implied author seems to bring the perception of his readers to a standpoint saying that Harlem was a final destination for blacks in the early 20th century, the time setting of the novel. Paradoxically, the novel gives a twisted ending by letting both of the main black characters in the novel, Jake and Ray, leave Harlem because of different reasons. This article aims to show a deferred meaning of “Home to Harlem” in the novel as well as to find the hidden aim in the novel. This research will use Derrida’s theory about deconstruction and differance concept. The result shows that the text seems to deconstruct a myth about Harlem as the mecca of the New Negro. The meaning of home in the novel has deferred into a space inhabited by a familiar in which one can find needs of physical, intellectual, mental, and emotional security. A decision to leave Harlem chosen by both of main characters in the novel is a symbol that Harlem cannot be the best representative of African American’s home enabling to meet all of blacks’ needs of racial equality in the early twentieth century.
克劳德·麦凯以他的第一部小说《哈林区之家》(1928年)的题目为例,似乎把读者的看法带到了这样一个立场上:在小说的时代背景——20世纪初,哈林区是黑人的最终目的地。矛盾的是,小说中的两个主要黑人人物杰克和雷因为不同的原因离开了哈莱姆区,给了一个扭曲的结局。本文旨在揭示《哈林区之家》在小说中的一种延后意义,并寻找小说隐藏的目的。本研究将运用德里达的解构理论和差异概念。结果表明,文本似乎解构了哈莱姆作为新黑人圣地的神话。在小说中,家的意义被推迟到一个熟悉的空间,在那里人们可以找到身体、智力、精神和情感上的安全需求。小说中两位主角选择离开哈莱姆的决定象征着哈莱姆不能成为非裔美国人家园的最佳代表它不能满足20世纪早期黑人对种族平等的所有需求。
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引用次数: 0
Risk Management Issues of Village Fund Management in Kedung Pengawas Village 克东彭加瓦斯村乡村基金管理的风险管理问题
Mochamad Muslih, Haryono Umar
The purpose of this study was to study the application of risk management in the management of village funds in Kedung Pengawas village, Babelan, West Java, Indonesia. The research method is a qualitative method with a case study of the application of risk management in Kedung Pengawas Village. The results showed that the Kedung Pengawas Bekasi Village Office Management has not implemented a formal integrated risk management, but there has been risk-conscious behavior so that certain crucial targets have been anticipated and steps will be taken in the event of obstacles so that performance targets can be achieved.
本研究的目的是研究风险管理在印尼西爪哇巴比兰Kedung Pengawas村村资金管理中的应用。研究方法采用定性方法,并以科东彭加瓦斯村风险管理应用为例进行研究。结果表明,Kedung Pengawas Bekasi村办事处管理部门没有实施正式的综合风险管理,但已经有了风险意识行为,以便预测某些关键目标,并在遇到障碍时采取措施,以便实现绩效目标。
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引用次数: 1
Utilization of Moodle in Increasing Motivation of Learning Chemistry Students 利用Moodle提高学生学习化学的积极性
Andrea Felicia Kurniawan, L. Purba, F. Simanjuntak
The ability and motivation of learning are different for each student, making the teacher to keep on changing, developing, and seeking the solutions in teaching. The core problem is motivation. Low motivation will impact the learning outcome. In the 21 century, model and learning methods have changed many times. One of them is the use of e-learning method. Learning Management System (LMS) is a part of e-learning. The example of LMS is Moodle. The aim of this research is to find out whether there is an increase in motivation of learning chemistry after using Moodle. This research is using a quantitative experiment design with one group pre-test and post-test design. The population of the research was all the students of BPK PENABUR Pharmacy Vocational School Jakarta academic year 2018/2019. Purposive sampling technique defines students of grade XI. Learning in the classroom had been done by using a direct learning method, in which Moodle was used as a supplement/complement learning at home. The research instrument was a motivation questionnaire with 20 numbers of statements. The sample of the research was fewer than 30 students, hence the test used was a non-parametric test. Based on the data analysis and hypothesis testing, we know that asymp. Sig. (2-tailed) is 0.002, where 0.002 < 0.05. In conclusion, the use of Moodle can increase the students’ motivation in learning chemistry of grade XI BPK PENABUR Pharmacy Vocational School Jakarta.
每个学生的学习能力和学习动机都是不同的,这使得教师在教学中不断地变化、发展、寻求解决方案。核心问题是动机。低动机会影响学习效果。在21世纪,学习模式和学习方法发生了多次变化。其中之一是使用电子学习方法。学习管理系统(LMS)是电子学习的一部分。LMS的例子是Moodle。本研究的目的是发现使用Moodle后是否有学习化学的动机增加。本研究采用定量实验设计,一组前测和后测设计。研究对象为雅加达BPK PENABUR药学职业学校2018/2019学年的所有学生。目的抽样技术定义了十一年级的学生。课堂学习采用直接学习法,Moodle作为在家学习的补充。研究工具为动机问卷,共20个题目。本研究样本少于30名学生,故采用非参数检验。根据数据分析和假设检验,我们知道。Sig.(双尾)为0.002,其中0.002 < 0.05。
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引用次数: 1
The Influence of Customer Relationship Management (CRM) on Customer Trust and Loyalty in PT Amartha Sejahtera 客户关系管理(CRM)对PT公司客户信任和忠诚的影响
F. Redjeki
This analysis aims to examine the impact of Customer Relationship Management (CRM) on PT Amartha Sejahtera customers' trust and loyalty both simultaneously and partially. PT Amartha Sejahtera is a company that provides and manages clean water for the area around Bandung Regency, especially in Cileunyi District, East Bandung. The research used was an associative survey method approach. Determination of data samples using an incidental sampling method. The unit of analysis is a customer who has been a regular customer for at least 3 months. The number of samples taken was as many as 150 people. Meanwhile, the analysis tool used is multiple regression. From the analysis, it can be concluded that simultaneous customer relationship management has a 49.6 percent positive and substantial impact on customer satisfaction. Meanwhile, partially the sub-variables of customer relationship management, namely financial bonds, and social bonds, see a 57.7 percent and 24.2 percent positive and substantial impact on consumer satisfaction. In contrast, customization bonds have a positive but negligible effect.
本分析旨在考察客户关系管理(CRM)对PT Amartha Sejahtera客户信任和忠诚度的影响,包括同时和部分影响。PT Amartha Sejahtera是一家为万隆县周边地区提供和管理清洁水的公司,特别是在东万隆的Cileunyi区。本研究采用关联调查方法。用附带抽样法测定数据样本。分析单元是至少3个月的老客户。抽取的样本数量多达150人。同时,使用的分析工具是多元回归。从分析中可以得出结论,同步客户关系管理对客户满意度有49.6%的积极和实质性影响。同时,客户关系管理的部分子变量,即金融债券和社会债券,对消费者满意度的积极和实质性影响分别为57.7%和24.2%。相比之下,定制债券具有积极但可以忽略不计的影响。
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引用次数: 0
Ing Ngarsa Sung Tuladha, Ing Madya Mbangun Karsa, Tut Wuri Handayani: Methods of Javanese Local Wisdom Used in Christian Religious Education
Stanley R. Rambitan
Method is very important in education, and in particularly Christian religious education. Methods are used in every work to produce something. It can be from any kind of culture and civilization. This research will concentrate on methods practiced in Javanese society, and in Christian traditions, namely The Old Testament and The New Testament. Methods practiced in the culture of Javanese and in the Bible are basically the same. Both sources give variety of methods which can be mixed or support one another. These methods are used in different context so the form might be different in accordance with the context of education. The research will be on the method of teaching in Javanese society in Indonesia and the teaching methods in the Bible, i.e. from the beginning of the existence of humankind and the ancestor of Israel and the prophets of Israel in the Old Testament, and in the New Testament as applied by Jesus and Paul. On how this research in done, the researcher or the writer study on the methods used in Javanese society namely ing ngarsa sung tuladha, ing madya mbangun karsa and tutwurihandayani. This research pursue to study the methods used in religious education in the Bible. Here, the research will study the available and relevant materials. This research produce a theses that methods as local wisdom in Javanese society are similar to methods used in the Bible. They can be used in modern time and will be useful if it is used in the right way.
方法在教育中非常重要,尤其是在基督教的宗教教育中。方法在每一项工作中都被用来产生某种东西。它可以来自任何一种文化和文明。这项研究将集中在爪哇社会和基督教传统,即旧约和新约中实践的方法。爪哇文化和圣经中实践的方法基本上是一样的。两个来源都提供了多种方法,这些方法可以混合使用或相互支持。这些方法在不同的环境中使用,因此形式可能根据教育环境而不同。研究将是印尼爪哇社会的教学方法和圣经中的教学方法,即从旧约中人类和以色列祖先和以色列先知的存在开始,以及耶稣和保罗在新约中应用的教学方法。关于这项研究是如何完成的,研究者或作者研究了爪哇社会中使用的方法,即ing ngarsa sung tuladha, ing madya mbangun karsa和tutwurihandayani。本研究旨在探讨圣经中宗教教育的方法。在此,本研究将研究现有的相关资料。本研究提出爪哇社会作为地方智慧的方法与圣经中使用的方法相似的论点。它们可以在现代使用,如果使用得当,将是有用的。
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引用次数: 1
Language Politeness 语言礼貌
M. Simatupang, Lamhot Naibaho
In communication, language politeness is a crucial aspect because it can shape one's language and character. This research was conducted to describe violations and obedience with the principle of language politeness of employees in carrying out daily routines at Indonesian Christian University. The research approach used is qualitative with a descriptive analysis design. Obtaining the research data, an audio recorder was used as an instrument, the data obtained through audio recorders were Analysed using the pragmatic method. The research results obtained are that the number of obedience with the language politeness principle among employees at Indonesian Christian University is greater than the violations or impoliteness. It can be seen from 248 utterances, 192 utterances that obey the principle of language politeness and 56 utterances that do not obey the language politeness. Violations in the utterances are violations, one maxim, two maxims and three maxims in one utterance. The maxim that was violated the most was the maxim of appreciation and the maxim of wisdom. It was also found that none of the employees obeys the maxim of simplicity from the utterances spoken. Thus, it can be concluded that the Indonesian Christian University requires a conduct training program to improve employee language politeness.
在交际中,语言礼貌是一个至关重要的方面,因为它可以塑造一个人的语言和性格。本研究旨在描述印尼基督教大学员工在日常工作中违反和遵守语言礼貌原则的情况。使用的研究方法是定性与描述性分析设计。获取研究数据时,使用录音机作为工具,用语用法对录音机所获得的数据进行分析。研究结果表明,印尼基督教大学员工中遵守语言礼貌原则的人数多于违反或不礼貌的人数。从248个话语中可以看出,遵守语言礼貌原则的话语有192个,不遵守语言礼貌原则的话语有56个。话语中的违犯就是违犯,一语违犯,二语违犯,三语违犯。被违背最多的格言是欣赏格言和智慧格言。我们还发现,从他们所说的话语中,没有一个员工遵守简单的准则。因此,可以得出结论,印尼基督教大学需要一个行为培训计划,以提高员工的语言礼貌。
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引用次数: 11
期刊
Proceedings of the 2nd Annual Conference on blended learning, educational technology and Innovation (ACBLETI 2020)
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