Pub Date : 2023-01-01DOI: 10.21608/smj.2023.182048.1359
H. Ahmed, Amr Ali, Reham Elsharkawy, E. Nada
{"title":"Eerectile dysfunction patients who are phospho diestrase enzyme type 5 inhibitors (PDE5Is) non responders: A review article.","authors":"H. Ahmed, Amr Ali, Reham Elsharkawy, E. Nada","doi":"10.21608/smj.2023.182048.1359","DOIUrl":"https://doi.org/10.21608/smj.2023.182048.1359","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134605128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2023.192450.1369
Ahmed Suliman Ahmed Ali
{"title":"Mechanical Thrombectomy In Treatment Of Acute Ischemic Stroke","authors":"Ahmed Suliman Ahmed Ali","doi":"10.21608/smj.2023.192450.1369","DOIUrl":"https://doi.org/10.21608/smj.2023.192450.1369","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126926914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2022.174446.1355
Sara Sleem, Zeinab Mahmoud kadry, E. Gad, AlShimaa Abd Elall
: Our review article discusses the relationship between systemic lupus erythematosus and the mannose-binding lectin gene. The complex trait of systemic lupus erythematosus (SLE), which manifests as a variety of clinical phenotypes and the production of several autoantibodies, is SLE. SLE patients experience a wide range of clinical phenotypes, such as skin rash, and neuropsychiatric, and musculoskeletal symptoms, some of which can progress to lupus nephritis. Abnormal complement activation causes inflammation, which damages multiple organs' tissue. About 50% of systemic lupus erythematosus patients, a chronic inflammatory disease, experience kidney damage. Despite effective anti-inflammatory and immunosuppressive therapies, lupus nephritis still results in end-stage kidney impairment (ESRD) or chronic kidney disorder (CKD) for an excessive number of patients. It represents a significant risk factor regarding mortality and morbidity in SLE. The family of C-type lectins of collectins includes the mannose-binding lectin (MBL), whose portion in the pre-immune first line of defense seems to involve pattern recognition. MBL can identify carbohydrate modes that abound on the surfaces of numerous pathogenic bacterial, viral, protozoal, and fungal microorganisms. The complement system's lectin pathway is activated when MBL binds to a microorganism. Numerous studies have linked MBL polymorphism, SLE, and lupus nephritis.
{"title":"Review Article: Is there a relationship between Systemic Lupus Erythematosus and the Mannose Binding Lectin gene?","authors":"Sara Sleem, Zeinab Mahmoud kadry, E. Gad, AlShimaa Abd Elall","doi":"10.21608/smj.2022.174446.1355","DOIUrl":"https://doi.org/10.21608/smj.2022.174446.1355","url":null,"abstract":": Our review article discusses the relationship between systemic lupus erythematosus and the mannose-binding lectin gene. The complex trait of systemic lupus erythematosus (SLE), which manifests as a variety of clinical phenotypes and the production of several autoantibodies, is SLE. SLE patients experience a wide range of clinical phenotypes, such as skin rash, and neuropsychiatric, and musculoskeletal symptoms, some of which can progress to lupus nephritis. Abnormal complement activation causes inflammation, which damages multiple organs' tissue. About 50% of systemic lupus erythematosus patients, a chronic inflammatory disease, experience kidney damage. Despite effective anti-inflammatory and immunosuppressive therapies, lupus nephritis still results in end-stage kidney impairment (ESRD) or chronic kidney disorder (CKD) for an excessive number of patients. It represents a significant risk factor regarding mortality and morbidity in SLE. The family of C-type lectins of collectins includes the mannose-binding lectin (MBL), whose portion in the pre-immune first line of defense seems to involve pattern recognition. MBL can identify carbohydrate modes that abound on the surfaces of numerous pathogenic bacterial, viral, protozoal, and fungal microorganisms. The complement system's lectin pathway is activated when MBL binds to a microorganism. Numerous studies have linked MBL polymorphism, SLE, and lupus nephritis.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"86 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127986916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2023.173669.1353
E. Gad, D. Gad, Sara Sleem, Z. Kadry, Enas Ahmed Abuzied
{"title":"Chronic Obstructive Pulmonary Disease: Pathogenesis and advanced treatment","authors":"E. Gad, D. Gad, Sara Sleem, Z. Kadry, Enas Ahmed Abuzied","doi":"10.21608/smj.2023.173669.1353","DOIUrl":"https://doi.org/10.21608/smj.2023.173669.1353","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115846084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2022.155462.1340
A. Abdelwahab, wafaa al sayed, Marwa Hashim, ramdan abdo
{"title":"Pityriasis Alba: An update on the epidemiologic features, etiopathogenesis and management","authors":"A. Abdelwahab, wafaa al sayed, Marwa Hashim, ramdan abdo","doi":"10.21608/smj.2022.155462.1340","DOIUrl":"https://doi.org/10.21608/smj.2022.155462.1340","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124601178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2022.154593.1338
Manar Sayed, Gharib Mohamed, H. Ibrahim, Mohamed Thabet
Cognitive decline in breast cancer patients can occur treatment related or non-treatment related. Disturbance of cognition can occur before start of any cancer therapy or in association with breast cancer therapy (e.g., radiation, hormonal therapy). Risk factors include a patient’s characteristics, such as psychological and genetic parameters other than the impact of cancer and cancer therapy. Incidence of cognitive disturbance in patients who receive chemotherapy is higher than patients receiving hormonal therapy, according to several surveys. Hypothesis of cognitive dysfunction includes increased systemic inflammation, mitochondrial dysfunction in neurons and Oxidative damage. Symptoms of cognitive dysfunction were more frequent in women who received high-dose chemotherapy, so that cognitive impairment is considered as treatment toxicity. Cognitive dysfunction was common among breast cancer patients as a toxic effect of chemotherapy. Complex attention, executive function, learning and memory are common affected domains. Pharmacologic treatment of cognitive dysfunction includes medication for dementia but without conclusive efficacy. Also, physical exercise is considered a suitable intervention, but has not been efficiently evaluated.
{"title":"Cognitive decline in patients of breast cancer at Sohag University Hospital","authors":"Manar Sayed, Gharib Mohamed, H. Ibrahim, Mohamed Thabet","doi":"10.21608/smj.2022.154593.1338","DOIUrl":"https://doi.org/10.21608/smj.2022.154593.1338","url":null,"abstract":"Cognitive decline in breast cancer patients can occur treatment related or non-treatment related. Disturbance of cognition can occur before start of any cancer therapy or in association with breast cancer therapy (e.g., radiation, hormonal therapy). Risk factors include a patient’s characteristics, such as psychological and genetic parameters other than the impact of cancer and cancer therapy. Incidence of cognitive disturbance in patients who receive chemotherapy is higher than patients receiving hormonal therapy, according to several surveys. Hypothesis of cognitive dysfunction includes increased systemic inflammation, mitochondrial dysfunction in neurons and Oxidative damage. Symptoms of cognitive dysfunction were more frequent in women who received high-dose chemotherapy, so that cognitive impairment is considered as treatment toxicity. Cognitive dysfunction was common among breast cancer patients as a toxic effect of chemotherapy. Complex attention, executive function, learning and memory are common affected domains. Pharmacologic treatment of cognitive dysfunction includes medication for dementia but without conclusive efficacy. Also, physical exercise is considered a suitable intervention, but has not been efficiently evaluated.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132890346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2022.168633.1348
H. Ahmed, M. Fattouh, Mohammed Ismail, A. Goda
The multistep process of rheumatoid arthritis (RA), a chronic autoimmune disease, includes the interaction of genetic, environmental, and behavioral risk factors that break immune tolerance and trigger autoimmune processes like the production of autoantibodies, the emergence of the first symptoms before the appearance of clinical arthritis, and finally the appearance of arthritis. In rheumatoid arthritis, the interleukin (IL)-17/IL-23 axis is a crucial pro-inflammatory mechanism (RA). IL-17 is the important factor of inflammation and is contribute to the destruction of bone by increasing the migration of cells, the gene expression of chemokines and the invasiveness of synoviocytes. There are a number of variations in the IL17A gene, and these polymorphisms may affect how IL-17 is expressed. The Th17 has been shown to be more effective than other cells in the development of autoimmune illness. In psoriasis and inflammatory bowel disease patients, IL-23 receptor gene variations were found to raise susceptibilities to autoimmune illness. Investigations also revealed that synovial fibroblasts and plasma from RA patients expressed more IL-23 than normal. Therefore, RA risk may be associated with IL-23 receptor gene variation.
{"title":"Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis","authors":"H. Ahmed, M. Fattouh, Mohammed Ismail, A. Goda","doi":"10.21608/smj.2022.168633.1348","DOIUrl":"https://doi.org/10.21608/smj.2022.168633.1348","url":null,"abstract":"The multistep process of rheumatoid arthritis (RA), a chronic autoimmune disease, includes the interaction of genetic, environmental, and behavioral risk factors that break immune tolerance and trigger autoimmune processes like the production of autoantibodies, the emergence of the first symptoms before the appearance of clinical arthritis, and finally the appearance of arthritis. In rheumatoid arthritis, the interleukin (IL)-17/IL-23 axis is a crucial pro-inflammatory mechanism (RA). IL-17 is the important factor of inflammation and is contribute to the destruction of bone by increasing the migration of cells, the gene expression of chemokines and the invasiveness of synoviocytes. There are a number of variations in the IL17A gene, and these polymorphisms may affect how IL-17 is expressed. The Th17 has been shown to be more effective than other cells in the development of autoimmune illness. In psoriasis and inflammatory bowel disease patients, IL-23 receptor gene variations were found to raise susceptibilities to autoimmune illness. Investigations also revealed that synovial fibroblasts and plasma from RA patients expressed more IL-23 than normal. Therefore, RA risk may be associated with IL-23 receptor gene variation.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114273943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/smj.2023.183672.1360
Enas Abuzied, Manar Sayed, A. Amin, S. Abdelaal, Rofaida M. Magdy, Ayman Abdelmotelb, E. Gad, D. Gad
{"title":"Obstructive Sleep Apnea and Alzheimer’s Disease: A Two-way Street.","authors":"Enas Abuzied, Manar Sayed, A. Amin, S. Abdelaal, Rofaida M. Magdy, Ayman Abdelmotelb, E. Gad, D. Gad","doi":"10.21608/smj.2023.183672.1360","DOIUrl":"https://doi.org/10.21608/smj.2023.183672.1360","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131944059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.167010.1347
samar ;Moahamed Kamel, Nagwa Ahmed, Muhammed Ahmed Abd El Moety, N. Zaki
: A category of metabolic illnesses known as diabetes mellitus (DM) is characterized by levels of hyperglycemia that persist for an extended length of time. The primary underlying cause of Type 2 diabetes mellitus (DM) is insulin resistance, which may also be accompanied by substantially decreased insulin production. The long-term presence of hyperglycemia causes several problems, including diabetic nephropathy. White adipose tissue (WAT) and brown adipose tissue (BAT) are the two separate compartments that make up adipose tissue. BAT has a thermogenic activity and controls body temperature by dissipating energy through heat generation. It is believed that the browning of adipose tissue will increase insulin sensitivity and lessen weight gain. Muscle-adipose tissue cross-talk may be facilitated by irisin, a newly identified exercise-mediated myokine that controls energy metabolism by transforming white into brown fat. When the precursor plasma membrane protein fibronectin type III domain-containing protein 5 (FNDC5) is broken down, irisin is created and released into the bloodstream. In individuals with diabetic nephropathy and chronic kidney disease (CKD), irisin was discovered to be related to renal functioning. To identify variations in the incidence of diabetic nephropathy among diabetic patients, the role of FDNC5 genetic polymorphism and irisin expression in T2DM nephropathy is being studied
{"title":"Role of FNDC5 gene polymorphism in patients with diabetic nephropathy","authors":"samar ;Moahamed Kamel, Nagwa Ahmed, Muhammed Ahmed Abd El Moety, N. Zaki","doi":"10.21608/smj.2022.167010.1347","DOIUrl":"https://doi.org/10.21608/smj.2022.167010.1347","url":null,"abstract":": A category of metabolic illnesses known as diabetes mellitus (DM) is characterized by levels of hyperglycemia that persist for an extended length of time. The primary underlying cause of Type 2 diabetes mellitus (DM) is insulin resistance, which may also be accompanied by substantially decreased insulin production. The long-term presence of hyperglycemia causes several problems, including diabetic nephropathy. White adipose tissue (WAT) and brown adipose tissue (BAT) are the two separate compartments that make up adipose tissue. BAT has a thermogenic activity and controls body temperature by dissipating energy through heat generation. It is believed that the browning of adipose tissue will increase insulin sensitivity and lessen weight gain. Muscle-adipose tissue cross-talk may be facilitated by irisin, a newly identified exercise-mediated myokine that controls energy metabolism by transforming white into brown fat. When the precursor plasma membrane protein fibronectin type III domain-containing protein 5 (FNDC5) is broken down, irisin is created and released into the bloodstream. In individuals with diabetic nephropathy and chronic kidney disease (CKD), irisin was discovered to be related to renal functioning. To identify variations in the incidence of diabetic nephropathy among diabetic patients, the role of FDNC5 genetic polymorphism and irisin expression in T2DM nephropathy is being studied","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128176405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.140389.1335
Amr Hamed, Khairy H Morsy, A. Mohammad, A. Abdel Aziz, Reem Abd El Hamed
: For cirrhotic ascitic individuals, spontaneous bacterial peritonitis is a potentially fatal outcome. Other tests for early spontaneous bacterial peritonitis diagnosis were looked upon, despite the fact that an ascitic polymorphonuclear leukocytes count of 250 cells/mm3 remains the gold standard for the diagnosis of spontaneous bacterial peritonitis. This article compiles and evaluates recent studies on spontaneous bacterial peritonitis diagnostic indicators such as procalcitonin, calprotectin, and homocysteine Many ascitic cytokines and chemokines, such as tumor necrosis factor-alp-ha, macrophage inhibitory protein-1 beta, interleukin-1 beta, interleukin-8, interleukin-10, and the soluble receptors of tumor necrosis factor-alpha, are more prevalent in patients with spontaneous bacterial peritonitis than in those without spontaneous bacterial peritonitis. Patients with spontaneous bacterial peritonitis had significantly higher serum high sensitivity C-reactive protein levels than those with sterile ascites. Ascites lactoferrin is a biomarker that can be used to diagnose and predict spontaneous bacterial peritonitis, and it was found to be lower in all spontaneous bacterial peritonitis patients who responded well to antibiotic therapy. Ascitic Calprotectin can distinguish between spontaneous bacterial peritonitis and non- spontaneous bacterial peritonitis patients, according to numerous research. Patients with spontaneous bacterial peritonitis had significantly higher ascitic and serum homocysteine levels than patients without spontaneous bacterial peritonitis. Instead of the second paracentesis, it might be used to assess the infection's eradication
{"title":"Biomarkers for Spontaneous bacterial peritonitis","authors":"Amr Hamed, Khairy H Morsy, A. Mohammad, A. Abdel Aziz, Reem Abd El Hamed","doi":"10.21608/smj.2022.140389.1335","DOIUrl":"https://doi.org/10.21608/smj.2022.140389.1335","url":null,"abstract":": For cirrhotic ascitic individuals, spontaneous bacterial peritonitis is a potentially fatal outcome. Other tests for early spontaneous bacterial peritonitis diagnosis were looked upon, despite the fact that an ascitic polymorphonuclear leukocytes count of 250 cells/mm3 remains the gold standard for the diagnosis of spontaneous bacterial peritonitis. This article compiles and evaluates recent studies on spontaneous bacterial peritonitis diagnostic indicators such as procalcitonin, calprotectin, and homocysteine Many ascitic cytokines and chemokines, such as tumor necrosis factor-alp-ha, macrophage inhibitory protein-1 beta, interleukin-1 beta, interleukin-8, interleukin-10, and the soluble receptors of tumor necrosis factor-alpha, are more prevalent in patients with spontaneous bacterial peritonitis than in those without spontaneous bacterial peritonitis. Patients with spontaneous bacterial peritonitis had significantly higher serum high sensitivity C-reactive protein levels than those with sterile ascites. Ascites lactoferrin is a biomarker that can be used to diagnose and predict spontaneous bacterial peritonitis, and it was found to be lower in all spontaneous bacterial peritonitis patients who responded well to antibiotic therapy. Ascitic Calprotectin can distinguish between spontaneous bacterial peritonitis and non- spontaneous bacterial peritonitis patients, according to numerous research. Patients with spontaneous bacterial peritonitis had significantly higher ascitic and serum homocysteine levels than patients without spontaneous bacterial peritonitis. Instead of the second paracentesis, it might be used to assess the infection's eradication","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130117331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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