Pub Date : 2022-09-01DOI: 10.21608/smj.2022.156011.1341
Shaimaa Mukhtar Abdelwahed, N. Nadi, E. Omran, Amal A. ABD ELMAWGOOD
Schistosomiasis is one of the public health threats in Egypt. S. hematobium infection significantly increases the risk of urinary bladder metaplasia and cancer. The study of the genetic diversity of S. hematobioum might help predict the severity of the disease and the resistance to treatment. In the present study, the DNA of the S. hematobium was amplified using RAPD-PCR from 27 urine samples and in addition, a positive control sample was used. We used RAPD-PCR primers (A01, A02, A12, A13, and Y20). DNA electrophoresis was done on a 1.2% agarose gel and samples were run with high molecular weight and a low-molecular weight100pb ladder. The samples generated a total of 182 bands with 5 primers. The average band numbers were 3 with primer A01, 2 with primer A02, 1 with primer A12, 3 with primer 3, and 2 with primer Y20. The average molecular weight for the generated bands with each primer was 938pb, 738pb, 1425pb, 1006pb, and 866pb respectively. Our results show genetic polymorphism in the samples specifically in primers A02, A13, and Y20. This genetic polymorphism was evident by the differences in the band numbers and weights (allelic composition). Further research is required to assess the relationship between genetic polymorphism and pathology caused by S. hematobium infection and finally the response to treatment.
{"title":"COMPARATIVE RESULTS OF RAPD-PCR GENETIC POLYMORPHISM OF SCHISTOSOMA HAEMATOBIUM","authors":"Shaimaa Mukhtar Abdelwahed, N. Nadi, E. Omran, Amal A. ABD ELMAWGOOD","doi":"10.21608/smj.2022.156011.1341","DOIUrl":"https://doi.org/10.21608/smj.2022.156011.1341","url":null,"abstract":"Schistosomiasis is one of the public health threats in Egypt. S. hematobium infection significantly increases the risk of urinary bladder metaplasia and cancer. The study of the genetic diversity of S. hematobioum might help predict the severity of the disease and the resistance to treatment. In the present study, the DNA of the S. hematobium was amplified using RAPD-PCR from 27 urine samples and in addition, a positive control sample was used. We used RAPD-PCR primers (A01, A02, A12, A13, and Y20). DNA electrophoresis was done on a 1.2% agarose gel and samples were run with high molecular weight and a low-molecular weight100pb ladder. The samples generated a total of 182 bands with 5 primers. The average band numbers were 3 with primer A01, 2 with primer A02, 1 with primer A12, 3 with primer 3, and 2 with primer Y20. The average molecular weight for the generated bands with each primer was 938pb, 738pb, 1425pb, 1006pb, and 866pb respectively. Our results show genetic polymorphism in the samples specifically in primers A02, A13, and Y20. This genetic polymorphism was evident by the differences in the band numbers and weights (allelic composition). Further research is required to assess the relationship between genetic polymorphism and pathology caused by S. hematobium infection and finally the response to treatment.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133815947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.159565.1342
O. Mahmoud, H. Azab, Yasser Mohammed, T. Sayed
: Background: A complex but frequent issue, challenging conduct among people with intellectual disabilities can be difficult for healthcare providers to diagnose and manage. A behaviour must have been perceived as problematic by another person for it to be classified as challenging behaviour. This means that challenging behaviour is a socially created, dynamic term. As a result, different cultures and environments may have different ideas of what constitutes a challenge. Challenging behaviour can appear as a side effect of mental illness (e.g., self-harm and aggression can be symptoms of depression), it can appear as an out-of-the-ordinary manifestation of a core symptom of a specific disorder (e.g., repetitive skin picking can be a symptom of an underlying obsessive-compulsive disorder), and it can be exacerbated by the symptoms of a mental illness. Some people's problematic behaviour may be caused by a variety of mechanisms. Conclusion: Psychosocial therapies and medication are two methods for controlling difficult behaviour. In cases where there is no documented psychiatric disorder, non-pharmacological therapies are the first line of treatment for aggression, according to a poll of psychiatrists . Interventions reduced problematic behaviour by at least 80% from baseline levels.
{"title":"Early intervention for challenging behaviour in intellectual disability","authors":"O. Mahmoud, H. Azab, Yasser Mohammed, T. Sayed","doi":"10.21608/smj.2022.159565.1342","DOIUrl":"https://doi.org/10.21608/smj.2022.159565.1342","url":null,"abstract":": Background: A complex but frequent issue, challenging conduct among people with intellectual disabilities can be difficult for healthcare providers to diagnose and manage. A behaviour must have been perceived as problematic by another person for it to be classified as challenging behaviour. This means that challenging behaviour is a socially created, dynamic term. As a result, different cultures and environments may have different ideas of what constitutes a challenge. Challenging behaviour can appear as a side effect of mental illness (e.g., self-harm and aggression can be symptoms of depression), it can appear as an out-of-the-ordinary manifestation of a core symptom of a specific disorder (e.g., repetitive skin picking can be a symptom of an underlying obsessive-compulsive disorder), and it can be exacerbated by the symptoms of a mental illness. Some people's problematic behaviour may be caused by a variety of mechanisms. Conclusion: Psychosocial therapies and medication are two methods for controlling difficult behaviour. In cases where there is no documented psychiatric disorder, non-pharmacological therapies are the first line of treatment for aggression, according to a poll of psychiatrists . Interventions reduced problematic behaviour by at least 80% from baseline levels.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131031887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.151992.1334
Lamees Hegab, Mustafa Younis, H. Abo-Elwafa
Recently, there has been an increasing interest in the study of mesenchymal stem cells (MSCs), which are considered as subtype of adult stem cells with the ability of differentiation into ectoderm (into neural cells), endoderm (into hepatocytes, insulin B producing cells) or mesoderm (into adipocytes, osteocytes, chondrocytes), this was associated with increased clinical application of such cells in the management of autoimmune diseases such as (Type 1 diabetes and Rheumatoid arthritis), degenerative diseases as (Parkinson‟s disease, Amylotrophic lateral sclerosis, and Alzheimer) and inflammatory diseases, and consequently increased the need for and effective and safe way of preservation of these cells for a long time without affecting the viability of the MSCs after the long-term preservation. This review discusses criteria of mesenchymal stem cells (MSCs), their markers, sources, methods of isolation and culturing, and their clinical applications, and then it discusses types of cryopreservation of MSCs and factors that may have an influence on viability of MSCs following the process of cryopreservation.
{"title":"Mesenchymal stem cells and Cryopreservation, a new concept","authors":"Lamees Hegab, Mustafa Younis, H. Abo-Elwafa","doi":"10.21608/smj.2022.151992.1334","DOIUrl":"https://doi.org/10.21608/smj.2022.151992.1334","url":null,"abstract":"Recently, there has been an increasing interest in the study of mesenchymal stem cells (MSCs), which are considered as subtype of adult stem cells with the ability of differentiation into ectoderm (into neural cells), endoderm (into hepatocytes, insulin B producing cells) or mesoderm (into adipocytes, osteocytes, chondrocytes), this was associated with increased clinical application of such cells in the management of autoimmune diseases such as (Type 1 diabetes and Rheumatoid arthritis), degenerative diseases as (Parkinson‟s disease, Amylotrophic lateral sclerosis, and Alzheimer) and inflammatory diseases, and consequently increased the need for and effective and safe way of preservation of these cells for a long time without affecting the viability of the MSCs after the long-term preservation. This review discusses criteria of mesenchymal stem cells (MSCs), their markers, sources, methods of isolation and culturing, and their clinical applications, and then it discusses types of cryopreservation of MSCs and factors that may have an influence on viability of MSCs following the process of cryopreservation.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122332709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.151381.1333
Manar Sayed, Gharib Mohamed, H. Ibrahim
Peripheral neuropathy induced by chemotherapy is considered the most common neurological disorder associated with chemotherapy. Different sites are involved in the mechanism of chemotherapy induced peripheral neuropathy and considered multifactorial. 68% of cases develop CIPN during the first month following the start of chemotherapy, 60% of cases develop CIPN within 3 months after chemotherapy and only 30% after 6 months. CIPN is caused by chemotherapeutic agents which include taxanes, platinum analogs, and vinca alkaloids. The clinical presentation of CIPN includes multiple symptoms that may cause functioning impairment and may require reduction of the dose of chemotherapy. CIPN considered a common sequel of different agents of chemotherapy and may last from months to years after chemotherapy completion. CIPN can be diagnosed by a detailed history and clinical examination. Clinical examination of a patient with CIPN can be done by the use of nerve conduction studies. Antidepressant includes tricyclic antidepressants and serotonin-noradrenaline reuptake inhibitors are common drugs used for CIPN. Patients may require reductions, substitutions, or stopping of chemotherapeutic agents according to the severity of symptoms.
{"title":"Chemotherapy Induced Peripheral Neuropathy in breast cancer Patients Gharib Fawi, Hazem K Elhewag, Mohamed Nasreldin Thabit, Manar Hamza Sayed","authors":"Manar Sayed, Gharib Mohamed, H. Ibrahim","doi":"10.21608/smj.2022.151381.1333","DOIUrl":"https://doi.org/10.21608/smj.2022.151381.1333","url":null,"abstract":"Peripheral neuropathy induced by chemotherapy is considered the most common neurological disorder associated with chemotherapy. Different sites are involved in the mechanism of chemotherapy induced peripheral neuropathy and considered multifactorial. 68% of cases develop CIPN during the first month following the start of chemotherapy, 60% of cases develop CIPN within 3 months after chemotherapy and only 30% after 6 months. CIPN is caused by chemotherapeutic agents which include taxanes, platinum analogs, and vinca alkaloids. The clinical presentation of CIPN includes multiple symptoms that may cause functioning impairment and may require reduction of the dose of chemotherapy. CIPN considered a common sequel of different agents of chemotherapy and may last from months to years after chemotherapy completion. CIPN can be diagnosed by a detailed history and clinical examination. Clinical examination of a patient with CIPN can be done by the use of nerve conduction studies. Antidepressant includes tricyclic antidepressants and serotonin-noradrenaline reuptake inhibitors are common drugs used for CIPN. Patients may require reductions, substitutions, or stopping of chemotherapeutic agents according to the severity of symptoms.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125186540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.164261.1345
Tarek Mahmoud Siefin, essam sallem, Hany Morsy, A. Abouzeid
Antenatal hydronephrosis is prenatal ultrasonography's most often detected urologic anomaly. Its etiology is quite variable ranging from mild abnormalities of the urinary system such as transient hydronephrosis to more significant ones such as ureteropelvic junction obstruction (UPJO) or high-grade vesicoureteral reflux (VUR). UPJO comprises the most encountered etiology of antenatal hydronephrosis with variable postnatal clinical scenarios ranging from complete resolution to the need for surgical intervention. The therapeutic approach for antenatal hydronephrosis caused by UPJO has undergone a dramatic shift from primary surgical intervention to initial conservation and elective surgery when indicated. Although there is a consensus that sustained increase in the grade of hydronephrosis, significant loss in differential renal function, and the existence of symptoms (such as recurrent UTI, nausea, vomiting, and cyclic flank pain) are reasonable indications of surgical need, precise cutoffs for the previous factors are still debated. This review aims to argue this debate and offer an overview of the antenatal and postnatal evaluation of antenatally detected ureteropelvic junction obstruction.
{"title":"Predictors of postnatal surgical intervention for Antenatally detected Ureteropelvic Junction Obstruction","authors":"Tarek Mahmoud Siefin, essam sallem, Hany Morsy, A. Abouzeid","doi":"10.21608/smj.2022.164261.1345","DOIUrl":"https://doi.org/10.21608/smj.2022.164261.1345","url":null,"abstract":"Antenatal hydronephrosis is prenatal ultrasonography's most often detected urologic anomaly. Its etiology is quite variable ranging from mild abnormalities of the urinary system such as transient hydronephrosis to more significant ones such as ureteropelvic junction obstruction (UPJO) or high-grade vesicoureteral reflux (VUR). UPJO comprises the most encountered etiology of antenatal hydronephrosis with variable postnatal clinical scenarios ranging from complete resolution to the need for surgical intervention. The therapeutic approach for antenatal hydronephrosis caused by UPJO has undergone a dramatic shift from primary surgical intervention to initial conservation and elective surgery when indicated. Although there is a consensus that sustained increase in the grade of hydronephrosis, significant loss in differential renal function, and the existence of symptoms (such as recurrent UTI, nausea, vomiting, and cyclic flank pain) are reasonable indications of surgical need, precise cutoffs for the previous factors are still debated. This review aims to argue this debate and offer an overview of the antenatal and postnatal evaluation of antenatally detected ureteropelvic junction obstruction.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133250545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/smj.2022.163420.1346
D. Mohamed, ekram abdel rhaman, Esam M. Abu AlFadl, A. Mohamed
The aetiology of Systemic Lupus Erythematosus (SLE), a chronic autoimmune disease that can affect every organ and tissue in the body, is unknown. However, complex interactions among genetic, environmental (such as infectious agents, ultraviolet light, drugs), and hormonal factors are likely to play a role. Human leukocyte antigen regulation, T- and B-cell signalling, Toll-like receptor/interferon signalling, nuclear factor-kB signalling, and immune complex clearance are a few immune system-related pathways that are primarily dysregulated in SLE pathogenesis. A lysosome-mediated catabolic process called autophagy allows cells to recycle nutrients and break down undesirable cytoplasmic components. Along with being involved in both innate and adaptive immune responses, autophagy is crucial for contacts with microorganisms, processing of antigens for MHC presentation, and the growth, survival, and proliferation of lymphocytes. Macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy are the three primary kinds of autophagy. The most often researched of them, known as autophagy in general, is macroautophagy. More than 100 loci related with SLE susceptibility have been found by hypothesis-free genome-wide association studies (GWAS). Five autophagy-related genes were found to be linked to SLE susceptibility using this method. These include ATG5, CLEC16A (C-type lectin domain containing 16A), DRAM1, CDKN1B (cyclin dependent kinase inhibitor 1B), and ATG16L2. These findings resoundingly confirmed the idea that autophagy is crucial to the genetic aetiology of SLE. Combining with additional follow-up investigations, it was shown that a number of variations in other autophagy-related genes, including ATG7, IRGM, LRRK2, MAP1LC3B, MTMR3, and APOL1, were linked to SLE susceptibility.
{"title":"the role of autophagy in systemic lupus erthymatosus","authors":"D. Mohamed, ekram abdel rhaman, Esam M. Abu AlFadl, A. Mohamed","doi":"10.21608/smj.2022.163420.1346","DOIUrl":"https://doi.org/10.21608/smj.2022.163420.1346","url":null,"abstract":"The aetiology of Systemic Lupus Erythematosus (SLE), a chronic autoimmune disease that can affect every organ and tissue in the body, is unknown. However, complex interactions among genetic, environmental (such as infectious agents, ultraviolet light, drugs), and hormonal factors are likely to play a role. Human leukocyte antigen regulation, T- and B-cell signalling, Toll-like receptor/interferon signalling, nuclear factor-kB signalling, and immune complex clearance are a few immune system-related pathways that are primarily dysregulated in SLE pathogenesis. A lysosome-mediated catabolic process called autophagy allows cells to recycle nutrients and break down undesirable cytoplasmic components. Along with being involved in both innate and adaptive immune responses, autophagy is crucial for contacts with microorganisms, processing of antigens for MHC presentation, and the growth, survival, and proliferation of lymphocytes. Macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy are the three primary kinds of autophagy. The most often researched of them, known as autophagy in general, is macroautophagy. More than 100 loci related with SLE susceptibility have been found by hypothesis-free genome-wide association studies (GWAS). Five autophagy-related genes were found to be linked to SLE susceptibility using this method. These include ATG5, CLEC16A (C-type lectin domain containing 16A), DRAM1, CDKN1B (cyclin dependent kinase inhibitor 1B), and ATG16L2. These findings resoundingly confirmed the idea that autophagy is crucial to the genetic aetiology of SLE. Combining with additional follow-up investigations, it was shown that a number of variations in other autophagy-related genes, including ATG7, IRGM, LRRK2, MAP1LC3B, MTMR3, and APOL1, were linked to SLE susceptibility.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"212 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116113465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.21608/smj.2022.123002.1320
Rasha R. Eid, G. Ismail, L. Yousef, Hesham M Hefny
Background: Carbapenemase-producing Enterobacteriaceae (CPE) represents a worldwide public health problem. One of the most important emerging resistance traits corresponds to the production of the carbapenem-hydrolysing β-lactamases, which confer resistance to almost all β-lactams Objectives : to determine the occurance of bla (NDM-1) gene among clinical isolates of multidrug resistant gram negative bacilli in Sohag University Hospital. Methodology: This study was prospectively conducted over a period of 24 months between Februray 2017 and January 2019, at Sohag university hospital. This study included 150 isolates obtained from various clinical specimens from patients admitted to different department in Sohag University Hospital with age ranged from 1 to 81 years old. Results : This study included 150 patients were infected by multi drug resistant gram negative bacilli, 100 of patients were resistant to carbapenem group (66.6%) and 50 patients were sensitive to carbapenem group (33.3%). There was no significant difference between the two groups regarding age (p value=0.782 ). Similarly, there was no significant difference between the two groups regarding sex distribution (p value=0.636). Most of cases was surgical site infection (34%) followed by respiratory tract infection (33.6) with no significant difference between groups regarding diagnosis (p value=0.25). In most of cases type of organism is klebsiella pneumonia (33 cases) 26 of them was positive NDM-1 gene followed by Escherichia coli (24 cases) 14 of them was positive NDM-1 gene. There is significant difference between groups regarding organism (p value=0.03). Conclusion : resistant enterobacteriacae are spreading in our locality and Egypt.
{"title":"Phenotypic Identification and Molecular Detection of bla (NDM-1) Gene in Multidrug Resistant Gram Negative Bacilli in Sohag University Hospital","authors":"Rasha R. Eid, G. Ismail, L. Yousef, Hesham M Hefny","doi":"10.21608/smj.2022.123002.1320","DOIUrl":"https://doi.org/10.21608/smj.2022.123002.1320","url":null,"abstract":"Background: Carbapenemase-producing Enterobacteriaceae (CPE) represents a worldwide public health problem. One of the most important emerging resistance traits corresponds to the production of the carbapenem-hydrolysing β-lactamases, which confer resistance to almost all β-lactams Objectives : to determine the occurance of bla (NDM-1) gene among clinical isolates of multidrug resistant gram negative bacilli in Sohag University Hospital. Methodology: This study was prospectively conducted over a period of 24 months between Februray 2017 and January 2019, at Sohag university hospital. This study included 150 isolates obtained from various clinical specimens from patients admitted to different department in Sohag University Hospital with age ranged from 1 to 81 years old. Results : This study included 150 patients were infected by multi drug resistant gram negative bacilli, 100 of patients were resistant to carbapenem group (66.6%) and 50 patients were sensitive to carbapenem group (33.3%). There was no significant difference between the two groups regarding age (p value=0.782 ). Similarly, there was no significant difference between the two groups regarding sex distribution (p value=0.636). Most of cases was surgical site infection (34%) followed by respiratory tract infection (33.6) with no significant difference between groups regarding diagnosis (p value=0.25). In most of cases type of organism is klebsiella pneumonia (33 cases) 26 of them was positive NDM-1 gene followed by Escherichia coli (24 cases) 14 of them was positive NDM-1 gene. There is significant difference between groups regarding organism (p value=0.03). Conclusion : resistant enterobacteriacae are spreading in our locality and Egypt.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122958202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.21608/smj.2022.118976.1302
Reem Abd El Hamed, A. Abdel Aziz, Moustafa Ali
{"title":"Recommendations and effect of COVID-19 vaccines","authors":"Reem Abd El Hamed, A. Abdel Aziz, Moustafa Ali","doi":"10.21608/smj.2022.118976.1302","DOIUrl":"https://doi.org/10.21608/smj.2022.118976.1302","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128060924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.21608/smj.2022.154165.1336
Walaa Elsamman, D. Gaber, Ahlam Mohamed
Background :green tea is one of the most famous beverages in the world. Green tea is a non-fermented tea that has a big amount of non oxidized polyphenols, named catechins which has been found to be effective in preventing many diseases. Many studies have been done to detect the effects of green tea extracts on various body systems. Aim of work: Our research aimed to study the possible effect of green tea in treatment of streptozotocin induced diabetes mellitus by studing its effect on rat pancreatic cells. Material an methods :A number of 15 adult male albino rats ( group I) then subdivided in to three groups group I control, group II STZ induced diabetics, group III STZ induced diabetics then treated with green tea.Then animals were sacrificed after six weeks and samples of pancreas were taken and prepared for Electron microscopic examination. Results :various histopathological changes are seen on streptozotocin induced diabetes pancreatic cells and these changes become less or near normal on group III treated with green tea after streptozotocin . Conclusion: green tea has protective and therapeutic effects on STZ induced diabetes in rats.So, further investigations on the effect of green tea are recommended.
{"title":"Effect of green tea on pancreas of streptozocin induced diabetes mellitus in adult albino rats (Electron microscopic study)","authors":"Walaa Elsamman, D. Gaber, Ahlam Mohamed","doi":"10.21608/smj.2022.154165.1336","DOIUrl":"https://doi.org/10.21608/smj.2022.154165.1336","url":null,"abstract":"Background :green tea is one of the most famous beverages in the world. Green tea is a non-fermented tea that has a big amount of non oxidized polyphenols, named catechins which has been found to be effective in preventing many diseases. Many studies have been done to detect the effects of green tea extracts on various body systems. Aim of work: Our research aimed to study the possible effect of green tea in treatment of streptozotocin induced diabetes mellitus by studing its effect on rat pancreatic cells. Material an methods :A number of 15 adult male albino rats ( group I) then subdivided in to three groups group I control, group II STZ induced diabetics, group III STZ induced diabetics then treated with green tea.Then animals were sacrificed after six weeks and samples of pancreas were taken and prepared for Electron microscopic examination. Results :various histopathological changes are seen on streptozotocin induced diabetes pancreatic cells and these changes become less or near normal on group III treated with green tea after streptozotocin . Conclusion: green tea has protective and therapeutic effects on STZ induced diabetes in rats.So, further investigations on the effect of green tea are recommended.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114836366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.21608/smj.2022.147182.1325
Sara Sleem, U. Rashad, I. Mohamed, A. Kasim, A. Ismail
: Introduction: Isolated sphenoid sinus lesions cause symptoms such as headache and visual abnormalities. Endoscopic examination and imaging modalities are mandatory to reach a diagnosis. Objectives : To validate the importance of a direct trans-nasal trans-sphenoid endoscopic approach as a minimally invasive surgical strategy in isolated sphenoid sinus and sellar lesions. Patients & Methods . There are 21 patients in our study, collected over 2 years period. we recorded all patients with isolated sphenoid sinus and sellar lesions. These patients were scheduled for a direct trans-nasal trans-sphenoid endoscopic approach for surgical management. Pituitary adenomas affect ten of them, and isolated sphenoid sinus lesions affect eleven. Complete medical history was taken, as well as general examination and local examination including full ENT examination including endoscopic examination, neurological examination, and ophthalmological examination. Routine laboratory investigations, hormonal assay (in patients with pituitary tumors), and radiological evaluation were done. Results : We faced 21 patients 10 of them had pituitary adenomas and 11 of them had isolated sphenoid sinus lesions. 7 patients had non-secretory pituitary adenomas, 3 patients had secretory adenomas, 4 patients had sphenoid sinus mucoceles, 2 patients had spheno-choanal polyps, 2 patients had isolated sphenoid sinus fungal sinusitis, one patient had a granulomatous lesion, one patient had a neoplastic lesion (squamous cell carcinoma), and one patient had unilateral isolated sphenoiditis. Conclusion: Direct trans-nasal trans-sphenoid endoscopic approach is the preferred option for optimal surgical management of patients with isolated sphenoid sinus and sellar lesions.
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