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Association Between Apelin and Nitrous Oxide with Essential Hypertensive Patient and their Relation toSex Apelin和一氧化氮与原发性高血压患者的关系及其与性别的关系
Pub Date : 2022-05-01 DOI: 10.21608/smj.2022.232079
Zeinab Mahmoud kadry, Alaa Mahmoud Ahmed, Asmaa Khalifa Ahmed, Alshimaa Hafez Abdelall, Samira Mahmoud Mohamed, A. Ahmed
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引用次数: 0
Animal Model of Non-Alcoholic Steatohepatitis in Histology Department Sohag University Sohag大学组织学系非酒精性脂肪性肝炎动物模型
Pub Date : 2022-05-01 DOI: 10.21608/smj.2022.232122
M. Mohamed
Non-alcoholic fatty liver disease (NAFLD) is characterized by the deposition of triglycerides in the hepatocytes causing their injury resulting in non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, as a healing response, and may progress to hepatocellular carcinoma (HCC). We aimed to establish an animal model for NAFLD/NASH by the use of a high-fat diet. A total number of 30 adult male mice were categorized into two groups; control, high-fat diet (HFD) 15 animals each. The livers of these animals were excised and processed for histological examination for the progress of NAFLD/NASH changes. At the end of the experiment, the mice were slaughtered at 11, 13, 15, and 17-week intervals. Liver specimens and blood samples from all animal groups were collected. The liver specimens were processed and stained with hematoxylin & eosin. Blood samples were processed for liver functions. Our results demonstrate that NASH was established 17 weeks after high-fat diet administration.
非酒精性脂肪性肝病(NAFLD)的特点是肝细胞内甘油三酯沉积,导致肝细胞损伤,导致非酒精性脂肪性肝炎(NASH)、纤维化和肝硬化,并可能发展为肝细胞癌(HCC)。我们旨在通过高脂肪饮食建立NAFLD/NASH动物模型。将30只成年雄性小鼠分为两组;对照组,高脂肪饮食组(HFD),每组15只。这些动物的肝脏被切除并进行组织学检查,以了解NAFLD/NASH变化的进展。实验结束时,每隔11周、13周、15周和17周屠宰小鼠。采集各组动物肝脏和血液标本。肝脏标本经苏木精和伊红染色处理。血液样本进行了肝功能检测。我们的研究结果表明,NASH在高脂饮食后17周建立。
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引用次数: 0
The pattern and outcome of poisoning among children admitted to Sohag University Hospitals 索海大学附属医院住院儿童中毒的模式和结果
Pub Date : 2022-05-01 DOI: 10.21608/smj.2022.119357.1303
Mai Abd ElKader, Palqees A. Mohammed, mohammed abd elaty
Introduction: poisoning is a major health problem among children that are affected by many factors. Each year a large number of children presented to hospitals with poisoning by different agents such as household products, over-the-counter medications, and others. This study aims to outline the pattern and outcome of poisoning cases among patients less than 18 years admitted to Sohag University Hospitals to find statistical relationships between children's toxicity and different factors and to start using a database for toxic cases in Sohag University Hospitals. Methods: The study is a cross-sectional study conducted on 91 acutely poisoned patients by different agents aged from 0 to 18 years old, who were admitted to Sohag University Hospitals in the period from October 2013 to September 20214. Data including sociodemographic data, causative agents, mode and route of poisoning, the delay time of presentation, and outcome. Results: among 91 children who presented with toxicity, toddlers and adolescents were the most affected (38.46 & 37.36 %). Females were more than males(61.54%). Accidental poisoning and oral route were the commonest mode and routes of poisoning respectively (71.43, 92.31 %). Pesticides were the commonest agent and most cases presented within 6 hours after poisoning. 52% of cases were discharged after 6 hours without complications and the mortality rate was 2.2%. Delay time and duration of hospitalization were factors that affected the outcome. Conclusion: childhood poisoning is a common problem that is affected by many factors so aware of them and their parents and preventive measures should be taken to decrease its occurrence.
中毒是儿童的一个主要健康问题,受多种因素影响。每年都有大量儿童因中毒而被送往医院,中毒的原因包括家用产品、非处方药物等。本研究旨在概述Sohag大学附属医院未满18岁患者中毒病例的模式和结果,寻找儿童毒性与不同因素之间的统计关系,并开始使用Sohag大学附属医院中毒病例数据库。方法:对2013年10月至2014年9月苏海大学附属医院收治的91例0 ~ 18岁不同药物急性中毒患者进行横断面研究。资料包括社会人口学资料、病原体、中毒方式和途径、出现延迟时间和结果。结果:91例中毒患儿中,以幼儿和青少年为最,分别占38.46%和37.36%。女性多于男性(61.54%)。意外中毒和口服途径分别是最常见的中毒方式(71.43%)和途径(92.31%)。农药是最常见的中毒原因,大多数病例在中毒后6小时内出现。52%的病例6小时后出院,无并发症,死亡率2.2%。延迟住院时间和住院时间是影响预后的因素。结论:儿童中毒是一种常见病,受多种因素影响,应引起家长的重视,采取预防措施,减少儿童中毒的发生。
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引用次数: 0
Osteoinductive Factor and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Literature Review 2型糖尿病患者骨诱导因子与糖尿病肾病:文献综述
Pub Date : 2022-05-01 DOI: 10.21608/smj.2022.131430.1315
A. Ramadan
: Diabetic kidney disease comprises a multifaceted etiopathology that includes glomerular hemodynamic changes, inflammation, oxidative stress, interstitial fibrosis, and tubular atrophy. Diabetic nephropathy (DN), or the pathological alterations in the capillaries caused by diabetes mellitus (DM), is the major cause of end-stage renal disease in diabetic individuals worldwide. Proteinuria, among other elements, as a diagnostic biomarker for DN, is a late change, and so does not detect controlled early nephropathic alterations. This needs the development of novel biomarkers that are more sensitive, specific, and early than proteinuria. Endothelial dysfunction and atherosclerosis are caused by DM, whereas glomerular hypertrophy, an increase in the extracellular matrix, and glomerular sclerosis are caused by DN. Osteogly-cin/Osteoinductive Factor (OGN) is a secretory small leucine-rich matrix/basement proteoglycan that regulates lipid and glucose metabolic activity, collagen fibrillogenesis, and cytokine availability in a paracrine/endocrine manner, and has been linked to the development of atherosclerosis, neovascularization, and angiogenesis. OGN is a pathogenic effector and biomarker that is extremely relevant to DM and DN because of these properties. OGN appears to be a better biomarker for DN than microalbuminuria, according to research. This literature review is intended to offer the most recent findings relevant to OGN's DN biomarker potential.
糖尿病肾病包括多方面的病因,包括肾小球血流动力学改变、炎症、氧化应激、间质纤维化和肾小管萎缩。糖尿病肾病(DN)或由糖尿病(DM)引起的毛细血管病理改变是全世界糖尿病患者终末期肾脏疾病的主要原因。蛋白尿,除其他因素外,作为DN的诊断性生物标志物,是一种晚期变化,因此不能检测出受控制的早期肾病改变。这就需要开发比蛋白尿更敏感、更特异、更早的新型生物标志物。内皮功能障碍和动脉粥样硬化是由糖尿病引起的,而肾小球肥大、细胞外基质增加和肾小球硬化是由糖尿病引起的。骨素/骨诱导因子(OGN)是一种分泌小的富含亮氨酸的基质/基底蛋白多糖,以旁分泌/内分泌的方式调节脂质和葡萄糖代谢活性、胶原纤维形成和细胞因子的可用性,并与动脉粥样硬化、新生血管和血管生成的发展有关。OGN是一种致病效应物和生物标志物,由于这些特性与DM和DN极其相关。根据研究,OGN似乎是比微量白蛋白尿更好的DN生物标志物。本文献综述旨在提供与OGN的DN生物标志物潜力相关的最新发现。
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引用次数: 0
Accuracy of point of care lung ultrasound in diagnosis of ventilator associated pneumonia in intensive care unit 监护点肺超声诊断重症监护病房呼吸机相关性肺炎的准确性
Pub Date : 2022-05-01 DOI: 10.21608/smj.2022.129605.1312
Wafaa Abd-Elsalam, S. Zahra, M. Abogabal, Wafaa madhy Atia
Objective: the objective of this study was to evaluate the accuracy of lung ultrasound in the diagnosis of pneumonia in critically ill patients admitted to the intensive care unit. Methods : This was an observational study conducted between March 2019 and February 2020 on patients older than 18 years who had symptoms associated with ventilator-associated pneumonia after 48 hours from admission to ICU. All patients were subjected to lung ultrasound examination by an intensive care physician who was not involved in the management of the patients. The final ICU diagnosis was the gold standard and was compared to the lung ultrasound diagnosis. Results: Among 108 patients included in this study 37 of them were confirmed to have pneumonia by the ICU team. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of lung ultrasound in the diagnosis of pneumonia in the intensive care unit were 94.87 %, 98.55 %, 97.37 %, 97.14 %, and 97.22%. Conclusion : lung ultrasound can be used with high accuracy in the diagnosis of ventilator-associated pneumonia.
目的:本研究的目的是评估肺部超声在重症监护病房重症患者肺炎诊断中的准确性。方法:这是一项观察性研究,于2019年3月至2020年2月期间对18岁以上、入院后48小时出现呼吸机相关性肺炎相关症状的患者进行研究。所有患者均由未参与患者治疗的重症监护医师进行肺部超声检查。最终的ICU诊断为金标准,并与肺部超声诊断进行比较。结果:本研究纳入的108例患者中,有37例经ICU团队确诊为肺炎。肺部超声诊断重症监护病房肺炎的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为94.87%、98.55%、97.37%、97.14%和97.22%。结论:肺超声诊断呼吸机相关性肺炎具有较高的准确性。
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引用次数: 0
Behavioral Intervention and its outcome in intellectual disability 智力障碍的行为干预及其结果
Pub Date : 2022-05-01 DOI: 10.21608/smj.2022.149801.1326
O. Mahmoud, H. Azab, Yasser Mohammed, T. Sayed
: Background: Healthcare personnel may face diagnostic and management difficulties when dealing with the complicated but prevalent issue of challenging behavior in people with intellectual impairments. Although challenging behavior is typical with intellectual impairment, it may be challenging to detect and treat. It may harm the person's quality of life and need hospitalization. This article covered the complicated link between mental illness and the etiology of problematic behavior (including the nuanced connection to mental illness), diagnostic issues, the most recent research on psychosocial and pharmaceutical therapies, and service provision. Conclusion: Positive behavioral support, a values-led and person-centered approach to behavioral treatments for decreasing problematic behavior, is gaining popularity. It is encouraging to think that evidence-based care for people with intellectual and developmental impairments and challenging behavior will improve as a result of the growing number of treatment options for this behavior and the ongoing development of research design, such as randomized controlled trials.
背景:在处理复杂但普遍存在的智力障碍患者挑战性行为问题时,卫生保健人员可能面临诊断和管理方面的困难。尽管挑战行为是智力障碍的典型表现,但它可能很难被发现和治疗。它可能会损害人的生活质量,需要住院治疗。这篇文章涵盖了精神疾病和问题行为的病因之间的复杂联系(包括与精神疾病的微妙联系),诊断问题,最新的社会心理和药物治疗研究,以及服务提供。结论:积极行为支持是一种以价值观为导向、以人为本的行为治疗方法,旨在减少问题行为。令人鼓舞的是,对智力和发育障碍以及具有挑战性行为的人的循证护理将得到改善,这是针对这种行为的治疗选择越来越多以及研究设计(如随机对照试验)不断发展的结果。
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引用次数: 0
The therapeutic effect of nanoparticles on toxoplasmosis: A review article 纳米颗粒治疗弓形虫病的研究进展
Pub Date : 2022-01-01 DOI: 10.21608/smj.2022.110371.1293
M. Gaballah, Nada A El Nadi, Ashraf Abd El Khalek Barakat, Noha S. Ahmed
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引用次数: 0
New Insight in The Use of Thoracic Ultrasonography in The Diagnosis of Interstitial Lung Diseases. 胸部超声在肺间质性疾病诊断中的新认识。
Pub Date : 2022-01-01 DOI: 10.21608/smj.2022.100647.1278
Hamdy A. Mohammadien, Enas Abuzied, Ashraf El Abidien, K. Alkhayat
:-Background: The ultrasonographic evaluation of Interstitial lung diseases (ILD) depends on the appearance and the quantification of multiple B-lines; which are produced by the reflection of the ultrasonographic beams from the subpleural thickened interlobar septa on the lung surface interface. Aim:- This study was conducted to assess the usefulness of Thoracic Ultrasonography (TUS) in the diagnosis of ILD, and to assess the correlations of the ultrasonographic features with radiological and functional parameters of ILDs. Patient and method:- Forty-six patients with ILD were included in this prospective study; each patient underwent Lung Ultrasonography (LUS), Multi-Detector CT chest (MDCT), and spirometry. Results:- The ultrasonographic findings in ILD patients were B lines in 96%, pleural line irregularity in 70%, fragmentation in 26%, thickening in 91% of cases, subpleural lesions was present in 26% of cases, diminished lung sliding was in 17% of cases. Increasing the distance between B lines was negatively correlated with both ground-glass opacities and Forced Vital Capacity (FVC), and positively correlated with disease duration and reticular opacities in High-Resolution Computed Tomography (HRCT). Conclusion:- TUS can be used as a complementary imaging technique for the diagnosis of ILD besides HRCT. The B-lines distance is considered as a sign of pulmonary function deterioration and a sign of disease severity.
背景:间质性肺疾病(ILD)的超声评价依赖于多条b线的表现和定量;它是由胸膜下增厚的叶间隔在肺表面界面上反射的超声光束产生的。目的:本研究旨在评估胸部超声(TUS)在ILD诊断中的价值,并评估超声特征与ILD放射学和功能参数的相关性。患者和方法:这项前瞻性研究纳入46例ILD患者;每位患者均行肺超声检查(LUS)、多层螺旋CT胸部检查(MDCT)和肺活量测定。结果:96%的ILD患者超声表现为B线,70%的胸膜线不规则,26%的胸膜断裂,91%的胸膜增厚,26%的胸膜下病变,17%的肺滑动减少。增加B线之间的距离与毛玻璃混浊和强迫肺活量(FVC)呈负相关,与疾病持续时间和高分辨率计算机断层扫描(HRCT)的网状混浊呈正相关。结论:- TUS可作为HRCT之外诊断ILD的辅助成像技术。b线距离被认为是肺功能恶化的标志和疾病严重程度的标志。
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引用次数: 0
Interleukin 17 role as a biomarker in Systemic Lupus Erythematosus patients. 白细胞介素17在系统性红斑狼疮患者中的生物标志物作用。
Pub Date : 2022-01-01 DOI: 10.21608/smj.2022.131003.1313
A. Mostafa, Amany Abd Allah, Sahar Abd Alwahed, R. Hafez, Safenaz Hussien, R. Bakry
: Objective: The purpose of this study is to determine the interleukin 17 (IL-17) level in cases with Systemic lupus erythematosus (SLE), in addition to assessing the correlation of IL-17 with the activity of the disease. Patients and Methods: The present research recruited 60 adult SLE cases versus 60 healthy subjects serving as controls. Subjects had a full clinical evaluation, history taking as well as evaluation of disease activity in cases with SLE via the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The serum level of IL-17 was measured in controls as well as SLE patients. Results: The IL-17 levels were substantially elevated in the SLE cohort than in controls. In addition, its level was positively related to SLEDAI. Conclusion: The present study findings revealed maximized IL-17 levels in SLE cases, denoting their contribution to the activity as well as the pathogenesis of the disease. Serum IL-17 levels were significantly positively related to the activity of the disease, 24 h protein in the urine, and anti-dsDNA.
目的:本研究的目的是测定系统性红斑狼疮(SLE)患者的白细胞介素17 (IL-17)水平,并评估IL-17与疾病活动度的相关性。患者和方法:本研究招募了60例成年SLE患者和60名健康受试者作为对照。通过系统性红斑狼疮疾病活动指数(SLEDAI)对受试者进行全面的临床评估、病史记录以及SLE病例的疾病活动评估。在对照组和SLE患者中测定血清IL-17水平。结果:SLE患者IL-17水平明显高于对照组。其水平与SLEDAI呈正相关。结论:本研究结果显示,IL-17水平在SLE病例中最高,表明其在疾病的活动和发病机制中所起的作用。血清IL-17水平与疾病活性、尿中24小时蛋白和抗dsdna呈显著正相关。
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引用次数: 0
Health Related Quality of Life in Attention Deficit Hyperactivity Disorder in Children 儿童注意缺陷多动障碍的健康相关生活质量
Pub Date : 2022-01-01 DOI: 10.21608/smj.2023.184208.1361
F. Mahmoud, N. Mohammed, F. Yousef
{"title":"Health Related Quality of Life in Attention Deficit Hyperactivity Disorder in Children","authors":"F. Mahmoud, N. Mohammed, F. Yousef","doi":"10.21608/smj.2023.184208.1361","DOIUrl":"https://doi.org/10.21608/smj.2023.184208.1361","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114249021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Sohag Medical Journal
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