Pub Date : 2026-01-08DOI: 10.1016/j.carbpol.2026.124901
Haitao Guo , Jiahui Wang , Yueying Yuan , Jinchai Qi , Shuqi Li , Heng Chen , Zhixing Huang , Hao Liu , Shaojun Yu , Zekun Yu , Gengyang Liu , Jing Han , Tao Ma , Yonggang Liu
Polygonatum kingianum is a known tonic herb of Traditional Chinese Medicine, extensively consumed in China, but the structure and activity of its polysaccharides remain to be clarified. In this study, a homogeneous fructan fraction, designated PKP-1b, was isolated and purified from this plant and structurally identified as an agavin-type fructan. In both Caenorhabditis elegans and a D-galactose-induced aging mouse model, PKP-1b exhibited significant anti-aging effects, including lifespan extension, improved motor function, reduced lipofuscin accumulation, and mitigation of neurodegenerative changes. Mechanistic investigations revealed that PKP-1b exerts its anti-aging effects by inhibiting the insulin/IGF-1 signaling (IIS) pathway, which in turn promotes nuclear translocation of the transcription factor DAF-16/FOXO, upregulates expression of the antioxidant gene sod-3, thereby enhancing overall antioxidant capacity and reducing oxidative damage. These findings elucidate the anti-aging mechanism of PKP-1b from P. kingianum and provide a theoretical foundation for its application in developing anti-aging products.
{"title":"Fructan PKP-1b from Polygonatum kingianum attenuates aging and neurodegeneration by inhibiting insulin/IGF-1 signaling","authors":"Haitao Guo , Jiahui Wang , Yueying Yuan , Jinchai Qi , Shuqi Li , Heng Chen , Zhixing Huang , Hao Liu , Shaojun Yu , Zekun Yu , Gengyang Liu , Jing Han , Tao Ma , Yonggang Liu","doi":"10.1016/j.carbpol.2026.124901","DOIUrl":"10.1016/j.carbpol.2026.124901","url":null,"abstract":"<div><div><em>Polygonatum kingianum</em> is a known tonic herb of Traditional Chinese Medicine, extensively consumed in China, but the structure and activity of its polysaccharides remain to be clarified. In this study, a homogeneous fructan fraction, designated PKP-1b, was isolated and purified from this plant and structurally identified as an agavin-type fructan. In both <em>Caenorhabditis elegans</em> and a D-galactose-induced aging mouse model, PKP-1b exhibited significant anti-aging effects, including lifespan extension, improved motor function, reduced lipofuscin accumulation, and mitigation of neurodegenerative changes. Mechanistic investigations revealed that PKP-1b exerts its anti-aging effects by inhibiting the insulin/IGF-1 signaling (IIS) pathway, which in turn promotes nuclear translocation of the transcription factor DAF-16/FOXO, upregulates expression of the antioxidant gene <em>sod-3</em>, thereby enhancing overall antioxidant capacity and reducing oxidative damage. These findings elucidate the anti-aging mechanism of PKP-1b from <em>P. kingianum</em> and provide a theoretical foundation for its application in developing anti-aging products.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124901"},"PeriodicalIF":12.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.carbpol.2026.124907
Xining He , Liang Lyu , Yawen Luo , Xiaoyuan Zheng , Fankui Zeng
Ultrasound-assisted starch modification has emerged as a promising green and efficient physical approach to improve the functionality of native starches. This review systematically summarizes recent progress in this field, emphasizing the optimization of ultrasonic parameters, structure–property correlations, and synergistic modification strategies. Ultrasonication induces cavitation and mechanical shear effects that disrupt starch crystalline regions, alter granule morphology, and increase specific surface area, resulting in enhanced solubility, hydrophilicity, and functional performance. The relationships between ultrasonic power, duration, temperature, and starch concentration and their effects on structural and physicochemical changes—such as crystallinity, thermal stability, rheology, and digestibility—are critically analyzed. Synergistic modification strategies combining ultrasound with enzymatic, chemical, or thermal treatments are also discussed, highlighting their potential to achieve controllable structural tailoring and improved efficiency. Finally, the review provides insights into current challenges and future prospects for industrial-scale applications of ultrasound-assisted starch modification, focusing on the development of intelligent, energy-efficient, and sustainable technologies for advanced starch-based materials.
{"title":"Advances in ultrasound-assisted starch modification: Parameter optimization, structure–property relationships, and synergistic strategies","authors":"Xining He , Liang Lyu , Yawen Luo , Xiaoyuan Zheng , Fankui Zeng","doi":"10.1016/j.carbpol.2026.124907","DOIUrl":"10.1016/j.carbpol.2026.124907","url":null,"abstract":"<div><div>Ultrasound-assisted starch modification has emerged as a promising green and efficient physical approach to improve the functionality of native starches. This review systematically summarizes recent progress in this field, emphasizing the optimization of ultrasonic parameters, structure–property correlations, and synergistic modification strategies. Ultrasonication induces cavitation and mechanical shear effects that disrupt starch crystalline regions, alter granule morphology, and increase specific surface area, resulting in enhanced solubility, hydrophilicity, and functional performance. The relationships between ultrasonic power, duration, temperature, and starch concentration and their effects on structural and physicochemical changes—such as crystallinity, thermal stability, rheology, and digestibility—are critically analyzed. Synergistic modification strategies combining ultrasound with enzymatic, chemical, or thermal treatments are also discussed, highlighting their potential to achieve controllable structural tailoring and improved efficiency. Finally, the review provides insights into current challenges and future prospects for industrial-scale applications of ultrasound-assisted starch modification, focusing on the development of intelligent, energy-efficient, and sustainable technologies for advanced starch-based materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124907"},"PeriodicalIF":12.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.carbpol.2026.124889
Aya A. Abdella , Ahmed Zayed
Polysaccharide-based molecularly imprinted polymers (PS-MIPs) represent a versatile class of biomimetic recognition materials that combine the advantages of natural polysaccharides with the selective recognition of the molecular imprinting technology. Polysaccharides such as chitosan, alginate, cellulose, and starch have been widely employed owing to their abundance of functional groups, intrinsic biocompatibility, renewability, and hydrophilicity, which make them particularly effective for imprinting in aqueous environments where conventional synthetic polymers often fail. Recent progress in PS-MIP design has focused on approaches, including surface imprinting, ion imprinting, and hybridization with nanomaterials, all of which enhance binding site accessibility, selectivity, and mechanical robustness. The greenness and sustainability of PS-MIPs are discussed in light of the AGREEMIP metric tool. Key performance indicators, morphological features, binding capacity, imprinting factor, selectivity coefficients, adsorption isotherms, kinetic models, and reusability, are discussed to provide a comparative framework for evaluating PS-MIPs. Moreover, applications are critically evaluated across environmental monitoring, biomedical diagnostics, pharmaceutical analysis, food safety, agriculture, and industrial catalysis, with particular emphasis on how polysaccharide backbones confer superior aqueous compatibility, tunable recognition, and multifunctional utility in sensors, adsorbents, and drug delivery platforms. However, the need for standardized reporting practices, scalable synthesis routes, and improved long-term stability are still remaining challenges.
{"title":"Polysaccharide-based molecularly imprinted polymers: Design, synthesis, sustainability, characterization, and applications","authors":"Aya A. Abdella , Ahmed Zayed","doi":"10.1016/j.carbpol.2026.124889","DOIUrl":"10.1016/j.carbpol.2026.124889","url":null,"abstract":"<div><div>Polysaccharide-based molecularly imprinted polymers (PS-MIPs) represent a versatile class of biomimetic recognition materials that combine the advantages of natural polysaccharides with the selective recognition of the molecular imprinting technology. Polysaccharides such as chitosan, alginate, cellulose, and starch have been widely employed owing to their abundance of functional groups, intrinsic biocompatibility, renewability, and hydrophilicity, which make them particularly effective for imprinting in aqueous environments where conventional synthetic polymers often fail. Recent progress in PS-MIP design has focused on approaches, including surface imprinting, ion imprinting, and hybridization with nanomaterials, all of which enhance binding site accessibility, selectivity, and mechanical robustness. The greenness and sustainability of PS-MIPs are discussed in light of the AGREEMIP metric tool. Key performance indicators, morphological features, binding capacity, imprinting factor, selectivity coefficients, adsorption isotherms, kinetic models, and reusability, are discussed to provide a comparative framework for evaluating PS-MIPs. Moreover, applications are critically evaluated across environmental monitoring, biomedical diagnostics, pharmaceutical analysis, food safety, agriculture, and industrial catalysis, with particular emphasis on how polysaccharide backbones confer superior aqueous compatibility, tunable recognition, and multifunctional utility in sensors, adsorbents, and drug delivery platforms. However, the need for standardized reporting practices, scalable synthesis routes, and improved long-term stability are still remaining challenges.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124889"},"PeriodicalIF":12.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.carbpol.2026.124904
Giulia Clare , Pedro N. Simões , Irina Smirnova , Luísa Durães
The exceptional properties of aerogels explain their growing applicability in different research areas. In the case of nutraceutical delivery, they hold the potential to improve the common challenges of poor bioavailability and low stability of the bioactive ingredients, thereby enhancing intestinal delivery. Starch aerogels offer additional attractive features: biocompatibility, potential cost reduction, and abundance of raw materials. This review explores the development of starch aerogels as carriers for nutraceutical delivery, and how it can be rationalized with molecular simulation. The fundamentals of starch aerogels and the existing literature on the carriers are explored, including synthesis procedure, morphology, nutraceutical loading, and characterization of the resulting delivery system. Molecular simulation is identified as a key tool for examining properties and interactions occurring at the nano- and sub-nanoscale. The current gaps in the field are critically discussed, and trending topics for future research are identified. A computational-assisted design combined with a systematic approach to production routes is needed to further develop the field of starch aerogels for nutraceutical delivery, in addition to assessing toxicity, stability during storage, and scale-up viability.
{"title":"Starch aerogels as nutraceutical carriers: Experimental and computational strategies for designing a delivery system","authors":"Giulia Clare , Pedro N. Simões , Irina Smirnova , Luísa Durães","doi":"10.1016/j.carbpol.2026.124904","DOIUrl":"10.1016/j.carbpol.2026.124904","url":null,"abstract":"<div><div>The exceptional properties of aerogels explain their growing applicability in different research areas. In the case of nutraceutical delivery, they hold the potential to improve the common challenges of poor bioavailability and low stability of the bioactive ingredients, thereby enhancing intestinal delivery. Starch aerogels offer additional attractive features: biocompatibility, potential cost reduction, and abundance of raw materials. This review explores the development of starch aerogels as carriers for nutraceutical delivery, and how it can be rationalized with molecular simulation. The fundamentals of starch aerogels and the existing literature on the carriers are explored, including synthesis procedure, morphology, nutraceutical loading, and characterization of the resulting delivery system. Molecular simulation is identified as a key tool for examining properties and interactions occurring at the nano- and sub-nanoscale. The current gaps in the field are critically discussed, and trending topics for future research are identified. A computational-assisted design combined with a systematic approach to production routes is needed to further develop the field of starch aerogels for nutraceutical delivery, in addition to assessing toxicity, stability during storage, and scale-up viability.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124904"},"PeriodicalIF":12.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.carbpol.2026.124903
Yuanyuan Ren , Yingjie Lei , Rui He , Jin Fu , Ding Ma , Geng Zhong
Inoculated fermentation improves rice noodle (RN) quality, but the underlying mechanisms of starch restructuring and their functional consequences remain unclear. This study monitored time-resolved changes in starch structure, functional properties, and RN cooking/textural performance. A 6 h fermentation produced the lowest cooking loss and the highest noodle hardness and springiness. At this optimum, coincident with α-amylase–mediated remodeling, B1-chain content, short-range order (R1047/1022), relative crystallinity, double-helix content, and mass fractal dimension increased by 5.81%, 16.67%, 28.20%, 5.84%, and 4.88%, respectively. Concomitantly, peak/trough viscosity and breakdown were minimized, whereas gelatinization enthalpy (ΔH) and setback peaked. Spearman correlations (p < 0.01) confirmed that ordered starch structures, particularly B1 chains, were strongly associated with pasting behavior and RN quality. Mechanistically, α-amylase activity enriched B1 chains, enhanced short-range order and crystallinity, and reinforced the gel network, reducing breakdown and cooking loss. These findings highlight the importance of capturing starch dynamics and provide mechanistic insight and actionable guidance for precise fermentation control to achieve improved RN quality.
{"title":"Time-dependent dynamics of starch structure, functionality and quality in rice noodles during inoculated fermentation","authors":"Yuanyuan Ren , Yingjie Lei , Rui He , Jin Fu , Ding Ma , Geng Zhong","doi":"10.1016/j.carbpol.2026.124903","DOIUrl":"10.1016/j.carbpol.2026.124903","url":null,"abstract":"<div><div>Inoculated fermentation improves rice noodle (RN) quality, but the underlying mechanisms of starch restructuring and their functional consequences remain unclear. This study monitored time-resolved changes in starch structure, functional properties, and RN cooking/textural performance. A 6 h fermentation produced the lowest cooking loss and the highest noodle hardness and springiness. At this optimum, coincident with α-amylase–mediated remodeling, B1-chain content, short-range order (R<sub>1047/1022</sub>), relative crystallinity, double-helix content, and mass fractal dimension increased by 5.81%, 16.67%, 28.20%, 5.84%, and 4.88%, respectively. Concomitantly, peak/trough viscosity and breakdown were minimized, whereas gelatinization enthalpy (ΔH) and setback peaked. Spearman correlations (<em>p</em> < 0.01) confirmed that ordered starch structures, particularly B1 chains, were strongly associated with pasting behavior and RN quality. Mechanistically, α-amylase activity enriched B1 chains, enhanced short-range order and crystallinity, and reinforced the gel network, reducing breakdown and cooking loss. These findings highlight the importance of capturing starch dynamics and provide mechanistic insight and actionable guidance for precise fermentation control to achieve improved RN quality.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124903"},"PeriodicalIF":12.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.carbpol.2026.124902
Zongkui Chen , Xinrui Li , Yue Huang , Xiangyu Xu , Jinghan Cao , Jiayue Wang , Ziyou Yu , Wenqi Yuan , Zhixin Li , Jingsha Tang , Zhonglin Wang , Zhiyuan Yang , Yongjian Sun , Jun Ma , Xiafei Li
Starch granules properties (crystallinity and bond-energy traits) largely determine rice cooking and eating quality (CEQ), and these properties are predominantly influenced by amylopectin. However, the role of amylopectin's structure and interaction with proteins in shaping starch granules properties and their response to panicle nitrogen fertilizer remains unclear. This study investigated how panicle nitrogen management improves CEQ by examining changes in amylopectin structure, its complexes with glutelin/prolamin, and starch granule properties during after-ripening period. Compare to other treatments, the panicle nitrogen fertilizer (N2; foliar spray at 45 kg N ha−1) increased key amylopectin density (e.g., 2A4B1B2B3), promoting amylopectin-protein complexes formation. The amylopectin structural changes exhibited higher structural stability and solvent-accessible surface area. Furthermore, N2 increased crystallinity and microstrain, while reducing interplanar spacing and surface functional groups abundance. Overall, optimized amylopectin structure and its interactions with proteins under N2 improved starch granules properties, particularly after two-month of after-ripening, thereby enhancing CEQ.
淀粉颗粒的性质（结晶度和键能性状）在很大程度上决定了大米的烹饪和食用品质（CEQ），这些性质主要受支链淀粉的影响。然而，支链淀粉的结构及其与蛋白质的相互作用在淀粉粒的形成及其对穗氮肥的响应中的作用尚不清楚。本研究通过考察支链淀粉结构、支链淀粉与麸质蛋白/蛋白复合物以及籽粒性状的变化，探讨了氮素管理对籽粒CEQ的影响。与其他处理相比，穗部施氮肥（N2；叶面喷施45 kg N ha−1）增加了关键支链淀粉密度（如2A4B1B2B3），促进了支链淀粉-蛋白复合物的形成。支链淀粉结构变化表现出较高的结构稳定性和溶剂可及表面积。此外，N2增加了结晶度和微应变，减少了面间距和表面官能团丰度。总体而言，优化后的支链淀粉结构及其在N2条件下与蛋白质的相互作用改善了淀粉颗粒的性质，尤其是熟后2个月后，从而提高了CEQ。
{"title":"Improving rice cooking and eating quality: Panicle nitrogen fertilizer modifies amylopectin structure and amylopectin-protein interactions in post-ripening","authors":"Zongkui Chen , Xinrui Li , Yue Huang , Xiangyu Xu , Jinghan Cao , Jiayue Wang , Ziyou Yu , Wenqi Yuan , Zhixin Li , Jingsha Tang , Zhonglin Wang , Zhiyuan Yang , Yongjian Sun , Jun Ma , Xiafei Li","doi":"10.1016/j.carbpol.2026.124902","DOIUrl":"10.1016/j.carbpol.2026.124902","url":null,"abstract":"<div><div>Starch granules properties (crystallinity and bond-energy traits) largely determine rice cooking and eating quality (CEQ), and these properties are predominantly influenced by amylopectin. However, the role of amylopectin's structure and interaction with proteins in shaping starch granules properties and their response to panicle nitrogen fertilizer remains unclear. This study investigated how panicle nitrogen management improves CEQ by examining changes in amylopectin structure, its complexes with glutelin/prolamin, and starch granule properties during after-ripening period. Compare to other treatments, the panicle nitrogen fertilizer (N2; foliar spray at 45 kg N ha<sup>−1</sup>) increased key amylopectin density (e.g., 2A4B1B2B3), promoting amylopectin-protein complexes formation. The amylopectin structural changes exhibited higher structural stability and solvent-accessible surface area. Furthermore, N2 increased crystallinity and microstrain, while reducing interplanar spacing and surface functional groups abundance. Overall, optimized amylopectin structure and its interactions with proteins under N2 improved starch granules properties, particularly after two-month of after-ripening, thereby enhancing CEQ.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124902"},"PeriodicalIF":12.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.carbpol.2026.124899
Kaipei Luo , Qiuxia Li , Siyin Chen , Qingya Jia , Yuxin Wu , Weiwei Liao , Yufei Su , Liping Chen , Xiao Wang , Zhimin Chen , Xiaofang Li , Ling Li , Lu Yang
Astragaloside IV (ASIV) is a triterpenoid saponin with promising potential in treating ulcerative colitis (UC), but its efficacy is hindered by poor solubility and rapid systemic clearance. Gliadin, an amphiphilic protein, has been widely used as a nanocarrier. Here, the novel edible pullulan-stabilized gliadin nanocomplexes (PL-Gli NPs) were developed to deliver ASIV. Interaction force analysis revealed that the formation of PL-Gli NPs involved in electrostatic interaction, hydrophobic interaction, and hydrogen bonding. ASIV was encapsulated into PL-Gli NPs via hydrophobic interaction to form ASIV-loaded nanocomplexes (ASIV@PL-Gli NPs). The resulting nanocomplexes had a particle size of (381.5 ± 5.3) nm and high encapsulation efficiency of 93.00 %. Notably, the stability of ASIV@PL-Gli NPs was improved under harsh conditions owing to the incorporation of pullulan. Furthermore, ASIV@PL-Gli NPs exhibited sustained release, with only 63.69 % cumulative release of ASIV at 10 h. Importantly, ASIV@PL-Gli NPs markedly enhanced anti-UC efficacy of ASIV, evidenced by a 51.81 % increase in colon length, a 53.16 % reduction in disease activity index scores, and significant decreases in pro-inflammatory cytokine levels. This work first employs pullulan and gliadin as oral nanocarriers for the delivery of ASIV, providing great potential for functional foods in UC treatment.
{"title":"Pullulan-stabilized gliadin nanocomplexes loaded with astragaloside IV: Fabrication, characterization and treatment of ulcerative colitis","authors":"Kaipei Luo , Qiuxia Li , Siyin Chen , Qingya Jia , Yuxin Wu , Weiwei Liao , Yufei Su , Liping Chen , Xiao Wang , Zhimin Chen , Xiaofang Li , Ling Li , Lu Yang","doi":"10.1016/j.carbpol.2026.124899","DOIUrl":"10.1016/j.carbpol.2026.124899","url":null,"abstract":"<div><div>Astragaloside IV (ASIV) is a triterpenoid saponin with promising potential in treating ulcerative colitis (UC), but its efficacy is hindered by poor solubility and rapid systemic clearance. Gliadin, an amphiphilic protein, has been widely used as a nanocarrier. Here, the novel edible pullulan-stabilized gliadin nanocomplexes (PL-Gli NPs) were developed to deliver ASIV. Interaction force analysis revealed that the formation of PL-Gli NPs involved in electrostatic interaction, hydrophobic interaction, and hydrogen bonding. ASIV was encapsulated into PL-Gli NPs <em>via</em> hydrophobic interaction to form ASIV-loaded nanocomplexes (ASIV@PL-Gli NPs). The resulting nanocomplexes had a particle size of (381.5 ± 5.3) nm and high encapsulation efficiency of 93.00 %. Notably, the stability of ASIV@PL-Gli NPs was improved under harsh conditions owing to the incorporation of pullulan. Furthermore, ASIV@PL-Gli NPs exhibited sustained release, with only 63.69 % cumulative release of ASIV at 10 h. Importantly, ASIV@PL-Gli NPs markedly enhanced anti-UC efficacy of ASIV, evidenced by a 51.81 % increase in colon length, a 53.16 % reduction in disease activity index scores, and significant decreases in pro-inflammatory cytokine levels. This work first employs pullulan and gliadin as oral nanocarriers for the delivery of ASIV, providing great potential for functional foods in UC treatment.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124899"},"PeriodicalIF":12.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.carbpol.2026.124893
Chotiwit Sriwong, Jasper van der Gucht, Joice Kaschuk
We present a novel approach that eliminates the need for multistep pretreatments and hazardous chemicals in the production of high-performance cellulose nanofibrils (CNF). Our single-pot method integrates delignification and carboxylation using hydrogen peroxide (H2O2) and organic acids while valorizing floricultural residues. By straightforward variation of acid type and sequence, different chemical modifications were observed, resulting in CNF with distinct fibrillation efficiencies, sizes, shapes, and colloidal stabilities. The most efficient treatment (citric acid–H2O2) effectively removed lignin (from 29.6 ± 1.0 % to 1.0 ± 0.2 %), producing CH-CNF with an average diameter of 3.16 nm, a high nanosized fraction (61.5 ± 0.5 %), carboxyl content of 426.2 ± 40 μmol g−1, and excellent colloidal properties. The Quality Index of CH-CNF (74.5), which integrates values of turbidity and nanosized fraction of the suspension and transmittance, Young's modulus, and porosity of nanopaper, was comparable to commercial TEMPO-CNF. This scalable, green method transformed floral waste into high-quality CNFs in fewer steps, utilizing green chemistry to support the advancement of circular economy strategies for more sustainable materials.
{"title":"Green single-pot oxidative systems for carboxylated nanocellulose production from rose-stem floriculture waste","authors":"Chotiwit Sriwong, Jasper van der Gucht, Joice Kaschuk","doi":"10.1016/j.carbpol.2026.124893","DOIUrl":"10.1016/j.carbpol.2026.124893","url":null,"abstract":"<div><div>We present a novel approach that eliminates the need for multistep pretreatments and hazardous chemicals in the production of high-performance cellulose nanofibrils (CNF). Our single-pot method integrates delignification and carboxylation using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and organic acids while valorizing floricultural residues. By straightforward variation of acid type and sequence, different chemical modifications were observed, resulting in CNF with distinct fibrillation efficiencies, sizes, shapes, and colloidal stabilities. The most efficient treatment (citric acid–H<sub>2</sub>O<sub>2</sub>) effectively removed lignin (from 29.6 ± 1.0 % to 1.0 ± 0.2 %), producing CH-CNF with an average diameter of 3.16 nm, a high nanosized fraction (61.5 ± 0.5 %), carboxyl content of 426.2 ± 40 μmol g<sup>−1</sup>, and excellent colloidal properties. The Quality Index of CH-CNF (74.5), which integrates values of turbidity and nanosized fraction of the suspension and transmittance, Young's modulus, and porosity of nanopaper, was comparable to commercial TEMPO-CNF. This scalable, green method transformed floral waste into high-quality CNFs in fewer steps, utilizing green chemistry to support the advancement of circular economy strategies for more sustainable materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"377 ","pages":"Article 124893"},"PeriodicalIF":12.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.carbpol.2026.124896
Shuai Li , Suxu Wang , Jun Zhao , Yuke Sun , Anle Yang , Zhihang Wang , Xiaofeng Xu
Footwear moisture accumulation from perspiration compromises comfort and hygiene. While sorption-based management is promising, conventional sorbents face leakage, slow kinetics, and poor mechanical fit. Herein, monolithic, hierarchical aerogels are fabricated via 3D printing of a biomass-based ink containing modified carboxymethyl cellulose (M-CMC), cellulose nanofibers (CNF), and carbon nanotubes (CNTs). Molecularly, substituting sodium ions (Na+) in CMC with quaternary ammonium cations via ion exchange introduces additional water-binding sites, resulting in a 24.7 % enhancement in the water uptake of M-CMC. Structurally, microscale parallel microchannels and macroscale interconnected pores synergistically reduce water vapor diffusion resistance and provide an expanded exposed active area for water sorption/desorption, enabling a rapid sorption timescale (τ = 225 min at 90 % RH) and a high desorption rate (1.05 % min−1 under 1 sun). Notably, moisture-saturated aerogel exhibits excellent elasticity and stable piezoresistive sensing, with precise/rapid dynamic pressure response and consistent signal stability over 8000 high-frequency compression cycles, effectively decoupling humidity and strain signals. When integrated into functional insoles, it simultaneously enables efficient moisture management and real-time motion monitoring. This work provides a scalable fabrication strategy for high-performance, multifunctional platform for next-generation smart footwear.
鞋湿积累从汗水妥协舒适和卫生。虽然基于吸附的管理是有前途的，但传统的吸附剂面临泄漏，缓慢的动力学和机械配合不良。本文通过3D打印含有改性羧甲基纤维素（M-CMC）、纤维素纳米纤维（CNF）和碳纳米管（CNTs）的生物质基油墨来制造单片、分层气凝胶。在分子上，通过离子交换用季铵离子取代CMC中的钠离子（Na+）引入了额外的水结合位点，导致M-CMC的吸水性提高了24.7%。在结构上，微观尺度的平行微通道和宏观尺度的互联孔隙协同降低了水蒸气扩散阻力，并为水的吸附/解吸提供了一个扩大的暴露活性区域，从而实现了快速的吸附时间尺度（在90% RH下τ = 225分钟）和高解吸率（在1个太阳下1.05% min - 1）。值得注意的是，湿饱和气凝胶具有优异的弹性和稳定的压阻传感，具有精确/快速的动态压力响应和超过8000次高频压缩循环的一致信号稳定性，有效地解耦了湿度和应变信号。当集成到功能性鞋垫时，它同时实现有效的水分管理和实时运动监测。这项工作为下一代智能鞋类的高性能、多功能平台提供了一种可扩展的制造策略。
{"title":"3D-printed hierarchical cellulose aerogels for integrated atmospheric water sorption, moisture management and motion monitoring in footwear","authors":"Shuai Li , Suxu Wang , Jun Zhao , Yuke Sun , Anle Yang , Zhihang Wang , Xiaofeng Xu","doi":"10.1016/j.carbpol.2026.124896","DOIUrl":"10.1016/j.carbpol.2026.124896","url":null,"abstract":"<div><div>Footwear moisture accumulation from perspiration compromises comfort and hygiene. While sorption-based management is promising, conventional sorbents face leakage, slow kinetics, and poor mechanical fit. Herein, monolithic, hierarchical aerogels are fabricated via 3D printing of a biomass-based ink containing modified carboxymethyl cellulose (M-CMC), cellulose nanofibers (CNF), and carbon nanotubes (CNTs). Molecularly, substituting sodium ions (Na<sup>+</sup>) in CMC with quaternary ammonium cations via ion exchange introduces additional water-binding sites, resulting in a 24.7 % enhancement in the water uptake of M-CMC. Structurally, microscale parallel microchannels and macroscale interconnected pores synergistically reduce water vapor diffusion resistance and provide an expanded exposed active area for water sorption/desorption, enabling a rapid sorption timescale (τ = 225 min at 90 % RH) and a high desorption rate (1.05 % min<sup>−1</sup> under 1 sun). Notably, moisture-saturated aerogel exhibits excellent elasticity and stable piezoresistive sensing, with precise/rapid dynamic pressure response and consistent signal stability over 8000 high-frequency compression cycles, effectively decoupling humidity and strain signals. When integrated into functional insoles, it simultaneously enables efficient moisture management and real-time motion monitoring. This work provides a scalable fabrication strategy for high-performance, multifunctional platform for next-generation smart footwear.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"377 ","pages":"Article 124896"},"PeriodicalIF":12.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.carbpol.2026.124897
Jiawen Li , Qinyi Zhu , Zhichao Yang , Yinuo Miao , Quancai Sun , Ye Peng , Yang Li , Yucheng Zou , Hui Zhang
In this work, electrospun short nanofiber aerogel-templated oleogels (ESNF-ATO) were fabricated by electrospun pullulan nanofibers. Spinning solutions with different concentrations were utilized to maintain fiber diameter, and short nanofibers were homogenized to prepare aerogel templates for oil adsorption. The shape of the templates could be easily controlled, and the fabrication process unchanged the properties of pullulan and the diameter of short nanofibers. Increasing the fiber diameter resulted in more flexible aerogel templates, which exhibited lower compressive strengths but higher recovery rates in 100-cycle fatigue tests. Simple linear fitting further confirmed the above results. Oleogels could be formed by rapid oil adsorption (normally within 100 s), and capillarity mainly induced this procedure. The thinner nanofibers provided the templates a high oil adsorption capacity (up to 69.05 g/g) but a relatively weakened oil holding capacity. ESNF-ATO exhibited good rheological properties, and could effectively realize the sustained-release of free fatty acids or lipo-soluble compounds. The significance of this work lied in the innovativeness of the combination of electrospun short nanofibers and aerogel templates, and the characteristics of fiber-based templates and oleogels were adjustable by modulating the fiber diameter.
{"title":"A novel strategy for preparing pullulan electrospun short nanofiber aerogel-templated oleogels with regulatability, compressibility and multi-functionality via rapid oil adsorption","authors":"Jiawen Li , Qinyi Zhu , Zhichao Yang , Yinuo Miao , Quancai Sun , Ye Peng , Yang Li , Yucheng Zou , Hui Zhang","doi":"10.1016/j.carbpol.2026.124897","DOIUrl":"10.1016/j.carbpol.2026.124897","url":null,"abstract":"<div><div>In this work, electrospun short nanofiber aerogel-templated oleogels (ESNF-ATO) were fabricated by electrospun pullulan nanofibers. Spinning solutions with different concentrations were utilized to maintain fiber diameter, and short nanofibers were homogenized to prepare aerogel templates for oil adsorption. The shape of the templates could be easily controlled, and the fabrication process unchanged the properties of pullulan and the diameter of short nanofibers. Increasing the fiber diameter resulted in more flexible aerogel templates, which exhibited lower compressive strengths but higher recovery rates in 100-cycle fatigue tests. Simple linear fitting further confirmed the above results. Oleogels could be formed by rapid oil adsorption (normally within 100 s), and capillarity mainly induced this procedure. The thinner nanofibers provided the templates a high oil adsorption capacity (up to 69.05 g/g) but a relatively weakened oil holding capacity. ESNF-ATO exhibited good rheological properties, and could effectively realize the sustained-release of free fatty acids or lipo-soluble compounds. The significance of this work lied in the innovativeness of the combination of electrospun short nanofibers and aerogel templates, and the characteristics of fiber-based templates and oleogels were adjustable by modulating the fiber diameter.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"377 ","pages":"Article 124897"},"PeriodicalIF":12.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号