Carbohydrate Polymers最新文献_第5页

A comprehensive nomenclature system for cyclodextrins

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-10 DOI: 10.1016/j.carbpol.2025.123600

Amelia M. Anderson , Matthew S. O'Connor , James Pipkin , Milo Malanga , Tamas Sohajda , Thorsteinn Loftsson , Lajos Szente , Rebeca García-Fandiño , Ángel Piñeiro

Modified cyclodextrins (CDs) are cyclic oligosaccharides with many applications in drug delivery, catalysis, and as active pharmaceutical ingredients. In general, they exist as distributions of structurally diverse molecules rather than single-isomer compounds. Their performance depends on the number of glucopyranose units (GPUs), and the type, number, and position of chemical substitutions in their hydroxyl groups. Effectively targeting individual species within these distributions is essential for optimizing CDs for specific applications. Computational techniques can generate large datasets to AI-driven structural optimization, but the absence of a standardized nomenclature system for modified CDs presents a major barrier to progress in this direction. This lack of consensus limits effective communication, data sharing, automation, and collaboration. To address this, a clear and extensible nomenclature for modified CDs is proposed. In this framework, GPUs are treated like amino-acid residues, with unsubstituted GPUs as reference building-blocks and substituted ones considered as mutations. This approach precisely defines substitution types and patterns, resolves cyclic permutation ambiguities, and offers versatility for both simple and complex modifications, including chiral center alterations and covalently linked CD oligomers. By introducing this standardized nomenclature, we aim to enhance molecular design, improve reproducibility, and streamline both experimental and computational research in the CD field.

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引用次数: 0

Proliferation and differentiation of human dental pulp stem cells on phosphorylated cellulose nanofiber scaffolds

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-09 DOI: 10.1016/j.carbpol.2025.123593

Akihiro Iwasaki , Mayumi Hatakeyama , Qimei Liu , Ai Orimoto , Tomokazu Fukuda , Takuya Kitaoka

Human dental pulp stem cells (hDPSCs) are a promising cell source for tooth regeneration therapies. However, conventional culture scaffold materials are often animal-derived, leading to immunogenicity concerns and limited availability. In this study, we explored phosphorylated cellulose nanofibers (P-CNFs), which have a fine fiber morphology and phosphate groups, as a novel scaffold material for cell culture. Immortalized hDPSCs were cultured on P-CNF scaffolds with different phosphate contents (0–1.42 mmol g⁻¹) prepared by varying the molar ratio of urea and diammonium hydrogen phosphate and the reaction time. Cells cultured on unmodified CNFs exhibited poor adhesion and formed spheroids, indicating low bioadaptability. In contrast, P-CNF scaffolds with moderate phosphate content (0.54–0.78 mmol g⁻¹) significantly improved cell adhesion; further increases in phosphate content decreased cell adhesion, indicating a strong dependence on phosphate content. Intriguingly, even in the absence of differentiation inducers, hDPSCs on P-CNF scaffolds with an optimal phosphate content of 0.78 mmol g⁻¹ showed equal or higher expression of hard tissue marker genes compared to collagen scaffolds with differentiation inducers, suggesting that P-CNFs can directly promote hard tissue differentiation. These findings highlight plant-derived, animal-free P-CNFs as a promising biomaterial for advanced dental tissue engineering.

人牙髓干细胞（hDPSCs）是牙齿再生疗法中一种前景广阔的细胞来源。然而，传统的培养支架材料通常来源于动物，导致免疫原性问题和可用性有限。在这项研究中，我们探索了磷酸化纤维素纳米纤维（P-CNFs），它具有精细的纤维形态和磷酸基团，可作为细胞培养的新型支架材料。通过改变尿素和磷酸氢二铵的摩尔比及反应时间，制备出不同磷酸盐含量（0-1.42 mmol g-1）的磷酸化纤维素纳米纤维支架，在支架上培养永生化的 hDPSCs。在未经改性的 CNF 上培养的细胞粘附性差并形成球状，表明其生物适应性低。相比之下，磷酸盐含量适中（0.54-0.78 mmol g-1）的 P-CNF 支架能显著提高细胞粘附性；磷酸盐含量进一步增加会降低细胞粘附性，这表明磷酸盐含量具有很强的依赖性。耐人寻味的是，即使在没有分化诱导剂的情况下，最佳磷酸盐含量为 0.78 mmol g-1 的 P-CNF 支架上的 hDPSCs 与含有分化诱导剂的胶原支架相比，硬组织标记基因的表达量相同或更高，这表明 P-CNFs 可以直接促进硬组织分化。这些研究结果突出表明，源于植物、不含动物成分的 P-CNFs 是一种用于先进牙科组织工程的前景广阔的生物材料。

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引用次数: 0

Cyclodextrin-based self-assembling hydrogel for Photothermal-controlled nitric oxide release in stage-specific treatment of MRSA-induced arthritis

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-09 DOI: 10.1016/j.carbpol.2025.123578

Guowei Li , Xiaohua Wei , Kai Lv , Dongna Xie , Mei Liu , Yi Xu , Dong Ma , Genlong Jiao

MRSA-induced arthritis is a prevalent and highly debilitating orthopedic condition. The inflammatory response induced by bacterial infection hinders tissue repair and exacerbates bone loss. Traditional antibiotic therapies are limited by low bioavailability, substantial side effects, and narrow efficacy, rendering them inadequate for comprehensive treatment of arthritis. Nitric oxide (NO) has demonstrated considerable potential in overcoming bacterial resistance, modulating immune responses, and facilitating tissue repair. Therefore, a stage-specific NO release strategy, tailored to the distinct phases of bacterial arthritis, is essential for effective treatment. In this study, mesoporous polydopamine nanoparticles were utilized as NO donors (mPDA/NONOate) and encapsulated within a supramolecular hydrogel formed via the host-guest interaction between α-cyclodextrin (α-CD) and Pluronic F127. The injectable nature of the resulting NO/PDA-Gel hydrogel ensured uniform distribution within irregular bone joint infection sites, minimizing NO donor loss and enhancing local bioavailability. Notably, upon near-infrared (NIR) irradiation, the hydrogel induces a rapid increase in local temperature, facilitating rapid NO release. At the same time, the synergistic photothermal effect effectively kills bacteria and rapidly controls the infection. Without light irradiation, NO is sustainably and stably released from the NO/PDA-Gel, modulating the bone immune microenvironment, alleviating inflammation, promoting chondrocyte proliferation and differentiation, and accelerating bone tissue repair, thus significantly shortening the healing time of MRSA-induced arthritis. In conclusion, the injectable self-assembled NO/PDA-Gel offers a precise, stage-matched therapeutic approach for MRSA-induced arthritis and holds promise for the treatment of deep-seated infections caused by other multidrug-resistant pathogens.

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引用次数: 0

Deciphering the interplay between pectin structural variability, intestinal bioavailability and gut microbiota metabolism: A review

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-09 DOI: 10.1016/j.carbpol.2025.123596

Yuanyuan Zhao , Violetta Aru , Dan Wang , Pan Wang , Peiyou Qin , Qianqian Jiang , Zudi Li , Søren Balling Engelsen , Xiaoyan Zhao

Pectins are parts of fruits, vegetables and other plant-based foods in the human daily diet. They are resilient to gastric digestion but undergo fermentation primarily in the large intestine, peaking in the cecum. The depolymerization of the pectins induced by the gut microbiota generally facilitates the subsequent fermentation of sugar monomers, during which SCFAs are primarily generated to exert multiple beneficial functions. Given structural heterogeneity of pectins and intricate process of microbial metabolism, it is crucial to elucidate how the multi-scale structure of pectins impacts their gut fermentation behavior. This review delves into distinct structural domains and fine structural characteristics of pectins, describes their degradation mechanism and bioavailability in the gastrointestinal tract, and provides an overview of the associated pectinolytic enzymes, gut microbiota community, and microbial metabolites. Moreover, recent advances are summarized in the relationships between gut fermentability and various structural parameters of pectins, including molecular size, esterification degree, monosaccharides composition and molecular conformation. Furthermore, how the structural complexity of pectins influences the interplay between saccharolytic metabolism and proteolytic metabolism during microbial fermentation is proposed. This work would help to unravel the “pectin structure - gut microbiota - host health” interactions, thereby guiding the design of functional foods targeting specific microorganisms in future personalized diets.

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引用次数: 0

Janus nanocellulose composite films with superior electromagnetic interference shielding and dual-thermal management Janus 纳米纤维素复合薄膜具有卓越的电磁干扰屏蔽和双重热管理功能

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-09 DOI: 10.1016/j.carbpol.2025.123585

Lujie Wang , Dingfeng Xu , Jinping Zhou

Constructing multifunctional conductive composite films with excellent electromagnetic interference (EMI) shielding properties, Joule heating and solar heating meet the demands of the communications industry, artificial intelligence and wearable smart devices. Furthermore, high-performance EMI shielding materials which can endure to harsh conditions have attracted significant attention of researchers. Herein, silver nanowires (AgNWs) were prepared by glycol reduction method and then combined with bamboo cellulose nanofiber (BCNF). At the same time, polyaniline (PANI) was polymerized in situ on the surface of BCNF, and a series of Janus structure BCNF-AgNWs/BCNF-PANI composite films were prepared by vacuum assisted filtration and vapor deposition. The composite film exhibited excellent electrical conductivity of 16,618 S cm⁻¹ and EMI shielding effectiveness of 103.2 dB, and could be adapted to harsh environments. Moreover, it also had good Joule heating performance (saturation temperature up to 152.0 °C at 1.5 V applied voltage) and photothermal conversion performance (saturation temperature up to 165.1 °C at 1.5 W cm⁻² power density irradiation), showing fast response time and good heating stability. The Janus composite film had a good application prospect in the field of EMI shielding and dual-drive heating.

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引用次数: 0

Enhancing salt resistance and all-day efficient solar interfacial evaporation of antibacterial sodium alginate-based porous hydrogels via surface patterning 通过表面图案化增强抗菌海藻酸钠基多孔水凝胶的耐盐性和全天候高效太阳能界面蒸发能力

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-08 DOI: 10.1016/j.carbpol.2025.123588

Yanzi Li , Baoshu Chen , Dahu Yao , Xiping Gao , Jing Chen , Chang Lu , Xinchang Pang

The fully bio-based solar-driven interfacial evaporator offers the advantage of being environmentally friendly, but achieving efficient evaporation throughout the day, good salt resistance, and excellent antibacterial properties remains a significant challenge. In this study, a fully bio-based porous hydrogel with a core-shell structure was prepared using sodium alginate (SA) as the matrix and pulp fiber (PF) as the reinforcing material. Crosslinking SA with Cu²⁺ ions imparts excellent antibacterial properties to the evaporator. In the hydrogel core, SA forms vertically aligned lamellar pore structures, with PF providing support between the layers, which gives the evaporator good mechanical properties, water transport capacity, and thermal insulation performance. The dense surface layer formed by SA contains CuS nanoparticles, resulting in high photothermal conversion efficiency. A trapezoidal pattern constructed on the surface enhances the evaporation rate by 14 % and improves salt resistance through the Marangoni effect, enabling the evaporator to maintain an evaporation rate of 2.42 kg m⁻² h⁻¹ in a 15 wt% saline solution. Additionally, the trapezoidal pattern increases the evaporation rate by 37.5 % at low incident angles, achieving efficient all-day evaporation. The prepared hydrogel shows great potential for seawater desalination applications.

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引用次数: 0

Chiral stationary phase based on chitosan Schiff base derivatives for enantioseparation

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-08 DOI: 10.1016/j.carbpol.2025.123590

Jing He , Jiangbo Xi , Bowen Han , Qi Xiao , Dandan Guo , Shaohua Huang

Chitosan derivatives play an important role in the field of enantioseparation due to their favorable chiral recognition properties. However, the preparation of chitosan derivatives with good chiral separation properties and organic solvent tolerance still needs further exploration. Herein, we report the synthesis of two types of chitosan Schiff bases via condensation reactions between chitosan and halogenated benzaldehydes, and subsequently modified with methyl-substituted phenylcarbamates, resulting in four chitosan-3,6-bis(phenylcarbamate)-2-Schiff base derivatives with high substitution degree. Thereafter, four chiral stationary phases were prepared by coating the chitosan derivatives onto aminopropyl silica gel and assessed for their enantioseparation performance using 20 chiral compounds via high-performance liquid chromatography. Findings show that the best chiral stationary phase recognizes 19 chiral compounds and provides a baseline separation of 10 chiral compounds, including a pharmaceutical intermediate ethyl mandelate (maximum resolution: 4.18) and aromatic amide-type chiral drugs. Based on the strong interaction of molecular forces in the structure of chitosan-3,6-bis(phenylcarbamate)-2-Schiff base derivatives, the chiral stationary phases based on chitosan Schiff base derivatives are tolerant to ethyl acetate and acetone. Furthermore, electronic circular dichroism analysis revealed that substituents at the C2, C3, and C6 positions significantly influenced the secondary structure of chitosan derivatives, and thus correlating with their enantioselectivity.

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引用次数: 0

Functional barrier and recyclable packaging materials through microfibrillated cellulose bilayer composite coatings

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-08 DOI: 10.1016/j.carbpol.2025.123592

Aakash Upadhyay , Lucian Lucia , Lokendra Pal

Although microfibrillated cellulose (MFC) offers high barrier properties against air, oxygen, and oil, its limited water resistance restricts industrial applications. An innovative bilayer composite coating (BCC) has therefore been developed in response, consisting of a top layer providing water resistance and the MFC layer contributing to the gas & oil barrier and recyclability. The top coating integrates styrene-butadiene copolymer for its non-polar characteristics and nanoclay to create a hydrophobic surface that resists moisture with enhanced tortuosity. Scanning electron microscopy confirmed a stable interface between the paper substrate and the BCC. X-ray photoelectron spectroscopy (XPS) and Time-of-Flight Secondary Ion Mass Spectroscopy (ToF-SIMS) show that the BCC prevents intermixing between layers, enhancing barrier performance and fiber recovery with reduced stickies during recycling. The BCC significantly improved barrier properties, achieving a 56 % reduction in water vapor transmission rate, a ∼ 630-fold decrease in air permeability, an oil & grease resistance of kit rating 12, and < 5 % weight gain from the hot oil test. These improvements highlight the efficacy of the BCC system for enhanced barrier and recyclability, especially in stickies reduction. This research demonstrates that the strategic combination of conventional and novel MFC materials can provide sustainable packaging with functional barriers and recyclability for a circular economy.

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引用次数: 0

Recyclable methylcellulose-based reversibly cross-linked hydroplastics with excellent environmental stability for use in flexible printed circuit boards capable of safe disposal

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-08 DOI: 10.1016/j.carbpol.2025.123591

Zhiqi Wang , Qing Bai , Wenjie Wang , Yunan Qing , Yixuan Li , Junqi Sun

Recyclable and degradable flexible bio-based plastics integrating high stability and efficient disintegration on demand are suitable for the fabrication of flexible printed circuit boards (FPCBs) capable of safe disposal. However, it is challenging to develop a facile and environmentally friendly method to fabricate such bio-based plastic substrates. Herein, recyclable and degradable reversibly cross-linked hydroplastics with high thermal stability and water stability used as the substrates of FPCBs are fabricated through the complexation of methylcellulose (MC) and tannic acid (TA) in pure water, followed by hot-pressing. Because of dynamic nanoconfinement phases, the bio-based hydroplastic (denoted as TA-MC) with a breaking strength of 109.6 MPa possesses a high storage modulus of 2.85 GPa at 180 °C. Even being immersed in water for 15 days, the hydroplastic still retains a high breaking strength of 40.4 MPa. Owing to the reversibility of hydrogen bonds, the hydroplastic can be recycled for several times. Moreover, FPCBs composed of flexible TA-MC substrates and 3D printed sensing components can be employed for reliable underwater detection. Electronic components can be easily separated from the FPCBs by dissolving TA-MC substrates in medical alcohol and residue polymer matrices, which degrade into non-toxic substances in soil, can be safely discarded without polluting the environment.

可回收和可降解的柔性生物基塑料具有高稳定性和按需高效分解的特点，适用于制造可安全处置的柔性印刷电路板（FPCB）。然而，开发一种简便、环保的方法来制造这种生物基塑料基材是一项挑战。在本文中，通过甲基纤维素（MC）和单宁酸（TA）在纯水中的复合物，然后进行热压，制备出可回收和可降解的可逆交联水塑料，这些水塑料具有高热稳定性和水稳定性，可用作柔性印刷电路板的基材。由于存在动态纳米嵌合相，在 180 °C 时，断裂强度为 109.6 MPa 的生物基水塑性塑料（称为 TA-MC）具有 2.85 GPa 的高存储模量。即使在水中浸泡 15 天，该水塑材料仍能保持 40.4 兆帕的高断裂强度。由于氢键的可逆性，水塑塑料可以多次循环使用。此外，由柔性 TA-MC 基板和 3D 打印传感元件组成的 FPCB 可用于可靠的水下探测。通过在医用酒精中溶解 TA-MC 基材，电子元件可以很容易地从 FPCB 中分离出来，残留的聚合物基质在土壤中降解为无毒物质，可以安全地丢弃，不会污染环境。

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引用次数: 0

Adsorbent semi-transparent cellulose-based self-standing thin films

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-04-07 DOI: 10.1016/j.carbpol.2025.123584

Andrea Brattelli , Luigi Gentile

Cellulose-based materials are emerging as versatile candidates for sustainable functional materials. This study presents a straightforward process to fabricate cellulose-based, self-standing films using 12 wt% microcrystalline cellulose (MCC) in an aqueous solution of 40 wt% tetrabutylammonium hydroxide (TBAH). TBAH, as an out-of-equilibrium solvent capable of dissolving MCC, is utilized to fabricate self-standing cellulose films through gelation induced by cellulose I–cellulose II precipitation.

The films exhibit moderate mechanical properties, with a Young's modulus approximately 460 MPa, tensile strength ranging from 1 to 4 MPa, and an elongation at break of about 2 %. The incorporation of zinc salts (0.2 M) does not significantly affect the overall mechanical properties. Their long-term stability is ensured by TBAH and zinc salts, both of which are known to prevent microbial growth. These films demonstrate a strong adsorption capacity for water-soluble contaminants like methylene blue, making them valuable for wastewater treatment and dye detection.

Their multifunctional attributes position them as sustainable materials for advanced applications, including antimicrobial packaging, water purification systems, and potentially biomedical technologies. Overall, these cellulose-based films offer promising solutions for critical global challenges.

纤维素基材料正在成为可持续功能材料的多功能候选材料。本研究介绍了一种在含 40% 四丁基氢氧化铵 (TBAH) 的水溶液中使用 12% 微晶纤维素 (MCC) 制造纤维素基自立薄膜的简单工艺。TBAH 作为一种能溶解 MCC 的失衡溶剂，通过纤维素 I-Cellulose II 沉淀引起的凝胶化作用，被用来制造自立纤维素薄膜。薄膜具有适中的机械性能，杨氏模量约为 460 兆帕，拉伸强度在 1 到 4 兆帕之间，断裂伸长率约为 2%。锌盐（0.2 M）的加入对整体机械性能没有明显影响。TBAH 和锌盐确保了薄膜的长期稳定性。这些薄膜对亚甲蓝等水溶性污染物有很强的吸附能力，因此在废水处理和染料检测方面很有价值。它们的多功能特性使其成为先进应用领域的可持续材料，包括抗菌包装、水净化系统以及潜在的生物医学技术。总之，这些纤维素基薄膜为应对严峻的全球性挑战提供了前景广阔的解决方案。

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引用次数: 0