Carbohydrate Polymers最新文献

英文中文

Corrigendum to “A nanocomposite xanthan gum/puerarin supramolecular hydrogel with immunoregulatory, antibacterial, and antioxidant properties for wound healing” [Carbohydrate Polymers 369 (2025) 124279] “一种纳米复合黄原胶/葛根素超分子水凝胶，具有免疫调节、抗菌和抗氧化特性，用于伤口愈合”[碳水化合物聚合物369(2025)124279]。

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-12-01 DOI: 10.1016/j.carbpol.2025.124663

Qingcong Wei , Zhenhua Fan , Hanwen Chen , Weiwei Zhang , Yuqin Jiang , Zhiguo Hu , Qigang Wang

引用次数: 0

Emerging strategies for polysaccharide modification and functional enhancement in food systems 食品系统中多糖改性和功能增强的新策略

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-30 DOI: 10.1016/j.carbpol.2025.124770

Abhishek Bisht , Mudassar Hussain , Gokulprasanth Murugan , Soottawat Benjakul , Jonas Viškelis

Polysaccharides, the most abundant natural biopolymers, exhibit outstanding biocompatibility and versatile functionality, making them valuable for applications in food, biomedicine and sustainable packaging. However, their native forms often suffer from limitations such as poor mechanical strength, thermal instability and rapid enzymatic degradation, which hinder broader industrial applications. This review critically examines recent advances in emerging modification techniques such as high-pressure processing, microwave treatment and cold plasma, etc., for enhancing the structural and functional properties of polysaccharides. Influence of modifications on rheological behavior, emulsification, hydrophobicity and gelation capacity were addressed, enabling advanced applications such as 3D-printing, plant-based meat structuring and controlled bioactive delivery. Special attention is given to green and sustainable modification strategies especially valorization of agri-food waste. Furthermore, the emerging role of artificial intelligence (AI) and molecular dynamics in predicting structure-function relationships are discussed, paving the way for data-driven design of polysaccharide-based materials. Despite these advancements, challenges remain in integrating modification techniques across disciplines and understanding their interactions within real food matrices. The unified framework addressing these challenges, emphasizing the need for scalable green technologies, life cycle assessments and AI-enabled digital twins are also proposed. This perspective positions modified polysaccharides as pivotal components of future clean label for multifunctional food systems, which are aligned well with circular bioeconomy goals.

多糖是最丰富的天然生物聚合物，具有良好的生物相容性和多种功能，在食品、生物医药和可持续包装等领域具有重要的应用价值。然而，它们的天然形式往往受到诸如机械强度差，热不稳定性和快速酶降解等限制，这阻碍了更广泛的工业应用。本文综述了高压处理、微波处理和冷等离子体等新兴改性技术在提高多糖结构和功能特性方面的最新进展。改性对流变行为、乳化、疏水性和凝胶能力的影响得到了解决，从而实现了3d打印、植物性肉类结构和可控生物活性递送等先进应用。特别关注绿色和可持续的改性战略，特别是农业食品废物的价值。此外，本文还讨论了人工智能（AI）和分子动力学在预测结构-功能关系方面的新兴作用，为多糖基材料的数据驱动设计铺平了道路。尽管取得了这些进步，但在整合跨学科的改性技术和理解它们在真实食物基质中的相互作用方面仍然存在挑战。还提出了解决这些挑战的统一框架，强调需要可扩展的绿色技术、生命周期评估和支持人工智能的数字孪生。这一观点将改性多糖定位为多功能食品系统未来清洁标签的关键组成部分，这与循环生物经济目标是一致的。

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引用次数: 0

Biotin-modified starch nanoparticles for resveratrol delivery: Encapsulation mechanism and synergistic efficacy in ulcerative colitis therapy 生物素修饰淀粉纳米颗粒递送白藜芦醇：溃疡性结肠炎治疗的包封机制和协同效应

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-30 DOI: 10.1016/j.carbpol.2025.124769

Chen-Chen Wang , Ran Feng , Fan Wang , Yan Liu , Bao Zhang

Resveratrol (RES) is a promising anti-inflammatory polyphenol for treating ulcerative colitis (UC), but its efficacy is constrained by poor solubility and colon-targeting efficiency. Biotin, as an active ligand, has been widely used to functionalize nanocarriers to enhance intestinal cell permeability, thereby increasing the absorption of bioactive components. Biotin modification enlarged the helical cavity of starch into a V7-type structure, creating a more favorable hydrophobic microenvironment for the encapsulation of guest molecules. The mass ratio of resveratrol to starch was 1:10 to 1:2, resveratrol acted as a nucleator, forming ordered B+V crystals with minimal size (312.4 nm), uniform distribution, and high encapsulation (20.02 %). Excess resveratrol distorted helices, causing aggregation and reduced efficiency. Biotin modification facilitating nanoparticles uptake by Caco-2 via receptor-mediated endocytosis. Furthermore, the colon length of colitis mice treated with resveratrol-loaded BSNP increased by 25 % (P < 0.001) compared to that of untreated colitis mice. RES@BSNP can increase the relative abundance of beneficial gut microbiota such as Christensenellales and Lactobacillus and suppressing pro-inflammatory factor secretion, ultimately alleviating UC. This work elucidates the role of guest-molecule concentration and biotin functionalization in starch-based nanoparticle design, offering a promising strategy for targeted polyphenol delivery in colitis treatment.

白藜芦醇（Resveratrol， RES）是治疗溃疡性结肠炎（UC）的一种很有前途的抗炎多酚，但其溶解性和结肠靶向性差限制了其疗效。生物素作为一种活性配体，被广泛用于功能化纳米载体，增强肠道细胞的通透性，从而增加生物活性成分的吸收。生物素修饰将淀粉的螺旋腔扩大为v7型结构，为客体分子的包封创造了更有利的疏水微环境。白藜芦醇与淀粉的质量比为1:10∶1:2，白藜芦醇作为成核剂，形成尺寸最小（312.4 nm）、分布均匀、包封率高（20.02%）的有序B+V晶体。过量的白藜芦醇扭曲螺旋，导致聚集和效率降低。生物素修饰促进纳米颗粒通过受体介导的内吞作用被Caco-2吸收。此外，与未治疗的结肠炎小鼠相比，使用白藜芦醇负载BSNP治疗的结肠炎小鼠的结肠长度增加了25% （P < 0.001）。RES@BSNP可以增加Christensenellales和Lactobacillus等有益肠道菌群的相对丰度，抑制促炎因子的分泌，最终缓解UC。这项工作阐明了客分子浓度和生物素功能化在淀粉基纳米颗粒设计中的作用，为结肠炎治疗中靶向多酚递送提供了一种有前途的策略。

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引用次数: 0

Enzymatic-chemical modification of cassava starch as a sauce thickener to regulate the balance between processing and edible quality 酶化学改性木薯淀粉作为酱料增稠剂调节加工品质与食用品质之间的平衡

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-30 DOI: 10.1016/j.carbpol.2025.124768

Qianling Zhang , Xiaoxiao Li , Zhengyu Jin , Birte Svensson , Yuxiang Bai

Acetylated distarch phosphate (ADSP), as a starch-based thickener, is extensively employed in sauces due to its excellent shear resistance properties. However, the cross-linking leads to an increase in texture roughness, and to chemically control a suitable degree of cross-linking to avoid compromising the texture presents a considerable challenge. In this work, Aspergillus oryzae α-amylase was selected to address this issue after screening four amylase candidates. The results showed that the α-amylase modification reduced the hysteresis loop area from 58.79 to 35.44 kPa·s⁻¹, which enhanced the anti-thixotropic properties of the gel. Besides, the enzyme modification maintained the frequency stability of ADSP, especially at extremely low and high frequencies. The edible quality of the modified starch applied in custard was analyzed using back-extrusion texture. Enzyme modification reduced firmness and increased the internal uniformity of the custard, indicating a softer and smoother mouthfeel. The enzymatically modified ADSP maintained the ordered gel network and reduced the amylose content from 16.46 % to 8.51 %, which may have caused the maintained processing stability and smooth texture. This study provided a novel starch-based thickener for sauces with excellent processing and edible properties, offering insights into how enzymatic-chemical modification alters starch properties and structure.

乙酰化二淀粉磷酸酯（ADSP）作为淀粉基增稠剂，因其优异的抗剪切性能而广泛应用于酱料中。然而，交联会导致织构粗糙度的增加，并且通过化学方法控制合适的交联程度以避免损害织构提出了相当大的挑战。本文在筛选了4种候选淀粉酶后，选择了米曲霉α-淀粉酶来解决这一问题。结果表明，α-淀粉酶修饰使凝胶的滞后环面积由58.79减小到35.44 kPa·s−1，增强了凝胶的抗触变性能。此外，酶修饰保持了ADSP的频率稳定性，特别是在极低频和高频。采用反挤压法对乳蛋奶糊中变性淀粉的食用品质进行了分析。酶修饰降低了蛋奶冻的硬度，增加了内部的均匀性，表明口感更柔软、更顺滑。经酶修饰的ADSP保持了有序的凝胶网络，将直链淀粉含量从16.46%降低到8.51%，保持了加工稳定性和光滑的质地。该研究提供了一种新型的淀粉基增稠剂，具有良好的加工和食用性能，为酶化学改性如何改变淀粉的性质和结构提供了新的见解。

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引用次数: 0

Phototunable dual-emitting and water-resistant cellulose acetate-based fluorescent materials 光可调谐双发射和防水醋酸纤维素基荧光材料

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-30 DOI: 10.1016/j.carbpol.2025.124773

Miao Wang , Junxin Zhu , Dan Zhou , Qiyuan Xie , Yijun Yao , Hailiang Wu

A water-resistant cellulose acetate (CA)-based fluorescent film with optically tunable dual-emitting property was synthesized using CA as the matrix, with fluorescein isothiocyanate (FITC) and inorganic phosphor CaAl₂O₄:Eu²⁺, Dy³⁺ (NH₂-CAO) as luminescent particles. Structural characterization via Fourier-transform infrared spectroscopy (FTIR), ¹H nuclear magnetic resonance (¹H NMR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) confirmed the successful grafting of FITC and NH₂-CAO onto CA molecular chains. The anchoring and dilution effects of the CA backbone effectively mitigated the aggregation-caused quenching of fluorophores, enabling CA-FITC and CA@NH₂-CAO systems to emit green (535 nm) and blue (485 nm) fluorescence in both solution and solid-film states, respectively. On the fluorescence spectrum of the CA-FITC@NH₂-CAO film, emission peaks corresponding to both FITC and NH₂-CAO were observed. A gradual increase in NH₂-CAO content induced chromatic transition and conferred a long afterglow effect. Moreover, the CA-based fluorescent films demonstrated water resistance and thermal stability. Compared with existing cellulose-based fluorescent films, this work achieved prolonged luminescence duration and superior water resistance performance, providing a novel strategy for developing biomass-derived smart textiles with water-resistant color-shifting coatings.

以异硫氰酸荧光素（FITC）和无机荧光粉CaAl2O4:Eu2+， Dy3+ (NH2-CAO)为发光粒子，以醋酸纤维素（CA）为基体，合成了具有光学可调双发射性能的防水荧光膜。通过傅里叶变换红外光谱（FTIR）、1H核磁共振（1H NMR）、x射线衍射（XRD）和x射线光电子能谱（XPS）进行结构表征，证实了FITC和NH2-CAO成功接枝到CA分子链上。CA骨架的锚定和稀释效应有效地减轻了聚集引起的荧光团猝灭，使CA- fitc和CA@NH2-CAO体系分别在溶液和固膜状态下发出绿色（535 nm）和蓝色（485 nm）荧光。在CA-FITC@NH2-CAO薄膜的荧光光谱上，可以观察到FITC和NH2-CAO对应的发射峰。NH2-CAO含量的逐渐增加诱导了颜色转变，并产生了长时间的余辉效应。此外，ca基荧光膜具有良好的耐水性和热稳定性。与现有的纤维素基荧光膜相比，该研究具有较长的发光时间和优异的耐水性，为开发具有防水变色涂层的生物质智能纺织品提供了新的策略。

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引用次数: 0

The potential role of bioactive marine polysaccharides applied in the cancer diagnosis and therapy 生物活性海洋多糖在癌症诊断和治疗中的潜在作用

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-30 DOI: 10.1016/j.carbpol.2025.124771

Shenghao Liu , Chao Geng , Zhijuan Liang , Liping Wang , Longhao Cui , Dan Li , Yuanbin Chen , Ye Liang

Cancer remains one of the most significant challenges in global public health, posing a serious threat to human health. Increasing attention has been directed toward natural compounds due to their diverse functions and unique properties in the treatment of cancer. Marine organisms provide abundant sources of polysaccharides, particularly from arthropods and algae. Among them, chitosan and its derivatives represent the primary polysaccharides derived from arthropods, while algal polysaccharides include carrageenan, agarose, porphyran, laminarin, alginate, fucoidan, and ulvan, among others. This study focuses on the unique roles of representative marine polysaccharides in cancer research, particularly in the simulation of the microenvironment in vitro, diagnosis, and therapeutic strategies. Their bioactivities and applications as scaffold materials are highlighted in chemotherapy, gene therapy, immunotherapy, photodynamic therapy, and photothermal therapy. Furthermore, the latest research advances and potential applications of marine polysaccharides in cancer research and treatment are systematically reviewed, providing a foundation for their continued development.

癌症仍然是全球公共卫生领域最重大的挑战之一，对人类健康构成严重威胁。由于天然化合物在治疗癌症方面具有多种功能和独特的性质，因此越来越受到人们的关注。海洋生物提供了丰富的多糖来源，尤其是节肢动物和藻类。其中，壳聚糖及其衍生物是来源于节肢动物的原生多糖，藻类多糖包括卡拉胶、琼脂糖、卟啉、层粘胶蛋白、海藻酸盐、岩藻聚糖和藻聚糖等。本研究的重点是具有代表性的海洋多糖在癌症研究中的独特作用，特别是在体外微环境模拟、诊断和治疗策略方面。其生物活性及其作为支架材料在化疗、基因治疗、免疫治疗、光动力治疗、光热治疗等方面的应用备受关注。系统综述了海洋多糖在癌症研究和治疗中的最新研究进展及潜在应用，为其进一步发展提供了基础。

{"title":"The potential role of bioactive marine polysaccharides applied in the cancer diagnosis and therapy","authors":"Shenghao Liu , Chao Geng , Zhijuan Liang , Liping Wang , Longhao Cui , Dan Li , Yuanbin Chen , Ye Liang","doi":"10.1016/j.carbpol.2025.124771","DOIUrl":"10.1016/j.carbpol.2025.124771","url":null,"abstract":"<div><div>Cancer remains one of the most significant challenges in global public health, posing a serious threat to human health. Increasing attention has been directed toward natural compounds due to their diverse functions and unique properties in the treatment of cancer. Marine organisms provide abundant sources of polysaccharides, particularly from arthropods and algae. Among them, chitosan and its derivatives represent the primary polysaccharides derived from arthropods, while algal polysaccharides include carrageenan, agarose, porphyran, laminarin, alginate, fucoidan, and ulvan, among others. This study focuses on the unique roles of representative marine polysaccharides in cancer research, particularly in the simulation of the microenvironment <em>in vitro</em>, diagnosis, and therapeutic strategies. Their bioactivities and applications as scaffold materials are highlighted in chemotherapy, gene therapy, immunotherapy, photodynamic therapy, and photothermal therapy. Furthermore, the latest research advances and potential applications of marine polysaccharides in cancer research and treatment are systematically reviewed, providing a foundation for their continued development.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"375 ","pages":"Article 124771"},"PeriodicalIF":12.5,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Preparation of injectable temperature-sensitive chitosan-based hydrogel for combined hyperthermia and chemotherapy of colon cancer” [Carbohydrate Polymers 222 (2019) 115039] “制备可注射的温度敏感壳聚糖水凝胶用于结肠癌热疗联合化疗”[碳水化合物聚合物222(2019)115039]的勘误表。

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-29 DOI: 10.1016/j.carbpol.2025.124518

Yuting Zheng , Weifan Wang , Jiulong Zhao , Chenyao Wu , Changqing Ye , Mingxian Huang , Shige Wang

引用次数: 0

A high-strength dense supramolecular gellan gel - metal-phenolic network gel: Application in the control of crystallization behavior of Active Pharmaceutical Ingredients 一种高强度致密超分子结冷胶-金属酚网络凝胶：在活性药物成分结晶行为控制中的应用

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-29 DOI: 10.1016/j.carbpol.2025.124767

Yitian Yu , Fan Wang , Danrong Zhao , Shengyu Zhang , Houshen Li , Dapeng Li , Yang Jiang

The size, morphology, and polymorphism of active pharmaceutical ingredients (APIs) are key determinants of pharmaceutical formulation performance. These properties are a focus of recent studies on supramolecular gels for drug crystallization. Unlike conventional gels composed solely of biological macromolecules, a supramolecular gel system (TA–Fe^III–GG) was constructed using gellan gum (GG) as the base framework and incorporating a TA–Fe^III coordination complex, enhancing the intermolecular interactions within the gel network. The crystallization of two model APIs, carbamazepine (CBZ) and vinpocetine (VIN), was investigated to evaluate the effect of spatial confinement on crystal morphology. Compared to GG alone, the TA–Fe^III–GG gel exhibited a denser network structure and higher mechanical strength. Consequently, the APIs crystals formed within this system displayed markedly altered morphologies, appearing as well-defined polyhedral block-shaped structures. As a result, CBZ crystals formed in the TA–Fe^III–GG gel exhibited a significantly slower release rate, with a complete release time approximately 1.8-fold longer than needle-like crystals. However, needle-like crystals are more easily obtained under conventional crystallization conditions, whereas block-like CBZ crystals are more advantageous in oral pharmaceutical applications. Therefore, this method proposes a new approach for controlling the morphology of API crystals, which can be used in sustained-release formulations.

活性药物成分（api）的大小、形态和多态性是药物配方性能的关键决定因素。这些性质是近年来用于药物结晶的超分子凝胶研究的热点。与传统的仅由生物大分子组成的凝胶不同，以结冷胶（GG）为基础框架，结合TA-FeIII配合物构建了一个超分子凝胶体系（ta - feii - GG），增强了凝胶网络内的分子间相互作用。研究了卡马西平（CBZ）和长春西汀（VIN）两种模型原料药的结晶过程，以评价空间约束对结晶形态的影响。与单独的GG相比，TA-FeIII-GG凝胶具有更致密的网络结构和更高的机械强度。因此，在该体系中形成的原料药晶体表现出明显改变的形态，表现为明确的多面体块状结构。结果表明，TA-FeIII-GG凝胶中形成的CBZ晶体释放速度明显较慢，完全释放时间约为针状晶体的1.8倍。然而，针状晶体在常规结晶条件下更容易获得，而块状CBZ晶体在口服药物应用中更有利。因此，该方法为控制原料药晶体的形态提供了一种新的方法，可用于缓释制剂。

{"title":"A high-strength dense supramolecular gellan gel - metal-phenolic network gel: Application in the control of crystallization behavior of Active Pharmaceutical Ingredients","authors":"Yitian Yu , Fan Wang , Danrong Zhao , Shengyu Zhang , Houshen Li , Dapeng Li , Yang Jiang","doi":"10.1016/j.carbpol.2025.124767","DOIUrl":"10.1016/j.carbpol.2025.124767","url":null,"abstract":"<div><div>The size, morphology, and polymorphism of active pharmaceutical ingredients (APIs) are key determinants of pharmaceutical formulation performance. These properties are a focus of recent studies on supramolecular gels for drug crystallization. Unlike conventional gels composed solely of biological macromolecules, a supramolecular gel system (TA–Fe<sup>III</sup>–GG) was constructed using gellan gum (GG) as the base framework and incorporating a TA–Fe<sup>III</sup> coordination complex, enhancing the intermolecular interactions within the gel network. The crystallization of two model APIs, carbamazepine (CBZ) and vinpocetine (VIN), was investigated to evaluate the effect of spatial confinement on crystal morphology. Compared to GG alone, the TA–Fe<sup>III</sup>–GG gel exhibited a denser network structure and higher mechanical strength. Consequently, the APIs crystals formed within this system displayed markedly altered morphologies, appearing as well-defined polyhedral block-shaped structures. As a result, CBZ crystals formed in the TA–Fe<sup>III</sup>–GG gel exhibited a significantly slower release rate, with a complete release time approximately 1.8-fold longer than needle-like crystals. However, needle-like crystals are more easily obtained under conventional crystallization conditions, whereas block-like CBZ crystals are more advantageous in oral pharmaceutical applications. Therefore, this method proposes a new approach for controlling the morphology of API crystals, which can be used in sustained-release formulations.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"375 ","pages":"Article 124767"},"PeriodicalIF":12.5,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction notice to “Bio-synthesis and applications of silver nanoparticles onto cotton fabrics” [Carbohydr. Polym. 90/2 (2012) 915–920] 《纳米银在棉织物上的生物合成及应用》的撤回通知[碳水化合物。高分子学报，90/2(2012):915-920。

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-29 DOI: 10.1016/j.carbpol.2025.124666

M.H. El-Rafie , Th.I. Shaheen , A.A. Mohamed , A. Hebeish

引用次数: 0

A novel fructan from Atractylodes macrocephala ameliorates ulcerative colitis through gut microbiota-mediated PI3K/Akt signaling 一种来自苍术的新型果聚糖通过肠道菌群介导的PI3K/Akt信号通路改善溃疡性结肠炎

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2025-11-29 DOI: 10.1016/j.carbpol.2025.124764

Jiangping Wu , Qiangbao Xu , Yiping Yang , Zhu Yang , Zihan Li , Lingzhi Chen , Yujia Song , Hui Che , Guodong Wang , Qiuyue Lv , Jun Han

Polysaccharides from edible and medicinal plants are promising natural agents for intestinal health. In this study, a homogeneous polysaccharide (AMP) was isolated from Atractylodes macrocephala Koidz. Structural characterization revealed that AMP (Mw = 3.56 kDa) primarily consisted of fructose (92.4 %) and glucose (7.6 %), with β-D-fructofuranose and α-d-glucopyranose residues linked through →1)-β-D-Fruf-(2→, →1,6)-β-D-Fruf-(2→, and α-D-Glcp-(1 → glycosidic bonds. In vivo studies confirmed the efficacy of AMP against ulcerative colitis (UC) in a DSS-induced mouse model, as evidenced by a significant improvement in disease symptoms, including increased body weight, longer colon length, and elevated goblet cell counts, coupled with a reduction in the disease activity index and histological damage. Mechanistically, AMP attenuated inflammation by restoring intestinal barrier integrity and regulating the gut microbiota to maintain its homeostasis. These regulatory effects were further validated through fecal microbiota transplantation (FMT) and antibiotic intervention (Abx). Olink proteomics and western blotting demonstrated that the ameliorative effect of AMP on UC, mediated via the PI3K/Akt pathway, was entirely dependent on the homeostasis of the gut microbiota. Collectively, these findings position AMP as a promising functional food ingredient or natural therapeutic for UC, providing a scientific basis for the high-value exploitation of A. macrocephala.

从食用和药用植物中提取的多糖是很有前途的天然肠道保健剂。本研究从苍术中分离得到一种均质多糖（AMP）。结构表征表明，AMP （Mw = 3.56 kDa）主要由果糖（92.4%）和葡萄糖（7.6%）组成，β- d-果糖呋喃糖和α-d-葡萄糖吡喃糖残基通过→1)-β- d- fruf -(2→，→1,6)-β- d- fruf -(2→，α-D-Glcp-(1→糖苷键连接。在dss诱导的小鼠模型中，体内研究证实了AMP对溃疡性结肠炎（UC）的疗效，证明了疾病症状的显著改善，包括体重增加、结肠长度延长、杯状细胞计数升高，以及疾病活动指数和组织学损伤的降低。从机制上讲，AMP通过恢复肠道屏障完整性和调节肠道微生物群以维持其稳态来减轻炎症。这些调节作用通过粪便微生物群移植（FMT）和抗生素干预（Abx）进一步验证。Olink蛋白质组学和western blotting表明，AMP对UC的改善作用是通过PI3K/Akt通路介导的，完全依赖于肠道微生物群的稳态。综上所述，这些发现表明AMP是一种很有前景的功能性食品成分或UC的天然治疗药物，为大头草的高价值开发提供了科学依据。

{"title":"A novel fructan from Atractylodes macrocephala ameliorates ulcerative colitis through gut microbiota-mediated PI3K/Akt signaling","authors":"Jiangping Wu , Qiangbao Xu , Yiping Yang , Zhu Yang , Zihan Li , Lingzhi Chen , Yujia Song , Hui Che , Guodong Wang , Qiuyue Lv , Jun Han","doi":"10.1016/j.carbpol.2025.124764","DOIUrl":"10.1016/j.carbpol.2025.124764","url":null,"abstract":"<div><div>Polysaccharides from edible and medicinal plants are promising natural agents for intestinal health. In this study, a homogeneous polysaccharide (AMP) was isolated from <em>Atractylodes macrocephala</em> Koidz. Structural characterization revealed that AMP (Mw = 3.56 kDa) primarily consisted of fructose (92.4 %) and glucose (7.6 %), with β-D-fructofuranose and α-<span>d</span>-glucopyranose residues linked through →1)-β-D-Fru<em>f</em>-(2→, →1,6)-β-D-Fru<em>f</em>-(2→, and α-D-Glc<em>p</em>-(1 → glycosidic bonds. In vivo studies confirmed the efficacy of AMP against ulcerative colitis (UC) in a DSS-induced mouse model, as evidenced by a significant improvement in disease symptoms, including increased body weight, longer colon length, and elevated goblet cell counts, coupled with a reduction in the disease activity index and histological damage. Mechanistically, AMP attenuated inflammation by restoring intestinal barrier integrity and regulating the gut microbiota to maintain its homeostasis. These regulatory effects were further validated through fecal microbiota transplantation (FMT) and antibiotic intervention (Abx). Olink proteomics and western blotting demonstrated that the ameliorative effect of AMP on UC, mediated via the PI3K/Akt pathway, was entirely dependent on the homeostasis of the gut microbiota. Collectively, these findings position AMP as a promising functional food ingredient or natural therapeutic for UC, providing a scientific basis for the high-value exploitation of <em>A. macrocephala</em>.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"375 ","pages":"Article 124764"},"PeriodicalIF":12.5,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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