Carbohydrate Polymers最新文献_第2页

Investigation of the reaction kinetics of 3-chloro-2-hydroxypropyl-N,N,N-trimethylammonium chloride (CHPTAC) with cellulose fibres 3-氯-2-羟丙基-N，N，N-三甲基氯化铵（CHPTAC）与纤维素纤维反应动力学研究

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-27 DOI: 10.1016/j.carbpol.2026.125021

Felix Netzer , Avinash P. Manian , Alistair W.T. King , Thomas Bechtold , Tung Pham

In the reaction system consisting of 3-chloro-2-hydroxypropyl-N,N,N-trimethylammonium chloride (CHPTAC), sodium hydroxide, cellulose and H₂O, it is widely accepted that the low reaction yield is the result of fast alkaline hydrolysis of CHPTAC. Some inconsistencies remain unexplained by rapid hydrolysis alone, indicating the need to understand the role of the cellulose-NaOH interaction to advance beyond the current state of the art. This raises two key questions: is NaOH uptake on cellulose decisive for cationisation yield, and is all epoxide consumed by end of the cationisation? Investigations into the reactions rates were conducted in the absence and the presence of cellulose fibres by applying a novel ion-exchange high-performance liquid chromatography method and nitrogen analysis to quantify both reactant in solution and product formation. It was found that hydrolysis rates are slower in the presence of the fibre, which was attributed to sorption of reactants, particularly sodium hydroxide, onto the fibre. The bonding of CHPTAC to cellulose shows initially high reaction rates but approaches a plateau, even though 40% of the cationisation agent is still available in solution. This phenomenon is attributed to the consumption of “active” (deprotonated) cellulose sites, highlighting the need for improved understanding of the cellulose-NaOH interaction, and its influence on derivatisation reactions.

在由3-氯-2-羟丙基-N，N，N-三甲基氯化铵（CHPTAC）、氢氧化钠、纤维素和H2O组成的反应体系中，普遍认为反应产率低是由于CHPTAC的快速碱性水解所致。一些不一致仍然无法通过快速水解来解释，这表明需要了解纤维素- naoh相互作用的作用，以超越目前的技术水平。这就提出了两个关键问题：纤维素对NaOH的吸收是否对阳离子化产率起决定性作用，以及在阳离子化结束时是否消耗了所有环氧化物？采用新型离子交换高效液相色谱法和氮分析定量测定溶液中的反应物和产物形成，研究了纤维素纤维存在和不存在情况下的反应速率。结果发现，在纤维存在的情况下，水解速率较慢，这是由于反应物（特别是氢氧化钠）在纤维上的吸附。CHPTAC与纤维素的结合最初显示出很高的反应速率，但接近平稳期，即使溶液中仍有40%的阳离子化剂可用。这种现象归因于“活性”（去质子化）纤维素位点的消耗，这突出了对纤维素-氢氧化钠相互作用及其对衍生化反应的影响的进一步了解的必要性。

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引用次数: 0

Chemically modified bacterial cellulose–mediated fiber salting-out method for preparing tough hydrogels 制备坚韧水凝胶的化学修饰细菌纤维素介导纤维盐析方法

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-27 DOI: 10.1016/j.carbpol.2026.124999

Bei Zhang , Xin-Xin Chen , Xiao-Rui Ge , Xin-Ping Wang , Xiao-Hui Yao , Wei-Guo Zhao , Tao Chen , Dong-Yang Zhang

Bacterial cellulose (BC) is employed as a toughening agent in the preparation of composite hydrogels. However, achieving both high strength and toughness after incorporating BC into hydrogels remains challenging. Insufficient amounts of BC limit the enhancement of strength, whereas excessive BC results in reduced elongation of hydrogels. Herein, a fiber salting-out method was developed to fabricate BC/polyvinyl alcohol (PVA) hydrogels by modifying BC with Hofmeister series ions (–COO⁻, –PO₃²⁻, –SO₃⁻). Through the fiber salting-out effect of BC, PVA was induced to aggregate on the BC surface, forming more crystalline domains and thereby improving the mechanical properties of the hydrogels. Among them, the tensile strength and toughness of the SBCP hydrogel (BC modified with –SO₃⁻) reached the highest values, measuring 2.98 MPa and 27.48 MJ m⁻³, respectively—representing 9-fold and 36-fold increases over those of pure PVA hydrogels. Furthermore, this hydrogel exhibits high electrical conductivity and favorable biocompatibility. This study presents a new strategy for fabricating tough BC-based hydrogels and provides insight into new applications for BC fibers.

采用细菌纤维素（BC）作为增韧剂制备复合水凝胶。然而，在将BC掺入水凝胶后实现高强度和高韧性仍然具有挑战性。BC量不足限制了强度的增强，而过多的BC会导致水凝胶伸长率的降低。本文采用Hofmeister系列离子（-COO−,-PO32−,-SO3−）对BC进行改性，制备了BC/聚乙烯醇（PVA）水凝胶。通过BC的纤维盐析作用，诱导PVA在BC表面聚集，形成更多的晶域，从而提高水凝胶的力学性能。其中，经-SO3−改性的SBCP水凝胶的抗拉强度和韧性最高，分别为2.98 MPa和27.48 MJ m−3，分别比纯PVA水凝胶提高了9倍和36倍。此外，该水凝胶具有高导电性和良好的生物相容性。该研究提出了一种制造坚韧的BC基水凝胶的新策略，并为BC纤维的新应用提供了见解。

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引用次数: 0

Multifunctional starch-based eutectogels with high mechanical properties, adhesion, self-healing, fatigue resistance and degradability for flexible wearable sensing 多功能淀粉基共凝胶，具有高机械性能，粘附性，自愈性，抗疲劳性和可降解性，用于柔性可穿戴传感

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-26 DOI: 10.1016/j.carbpol.2026.125018

Dadong Sun , Zhihua Xu , Li Guo , Bin Yu , Lu Lu , Bo Cui , Xuemin Kang , Zhijun Zhang , Fanfu Meng , Chenghai Li , Guowei Cai

Flexible wearable sensors have developed rapidly due to the urgent demands for human motion monitoring. Eutectogel-based soft materials have exhibited great potential for wearable sensing applications. However, it is still a challenge to develop multifunctional eutectogels with excellent mechanical properties, adhesion, self-healing, fatigue resistance and degradability. In this work, a multifunctional starch-based eutectogel was developed by a one-pot and in-situ photo-polymerization method. The eutectogel had excellent stretchability (2710%), high strength (5.43 MPa), toughness (94.38 MJ/m³), Young's modulus (10.23 MPa), adhesion, fatigue resistance (1000 cycles), degradability and a certain degree of self-healing ability. These properties were closely correlated to the synergistic effect among the amylopectin, polyacrylic acid and choline chloride via hydrogen-bond and electrostatic interactions. The mechanical properties of eutectogel can be adjusted by changing the starch content. A wearable sensor based on the eutectogel was realized accurate and stable monitoring of human joint motions. This study addressed the limitations of the dehydration and single function of the traditional hydrogels, and provides a novel way for the development of the multifunctional bio-based gels for next-generation flexible wearable devices.

由于人体运动监测的迫切需求，柔性可穿戴传感器得到了迅速发展。共聚物基软材料在可穿戴传感应用中显示出巨大的潜力。然而，开发具有优异力学性能、粘附性、自愈性、抗疲劳性和可降解性的多功能共凝胶仍然是一个挑战。本文采用一锅原位光聚合法制备了一种多功能淀粉基共聚物。共聚物具有优良的拉伸性（2710%）、高强度（5.43 MPa）、高韧性（94.38 MJ/m3）、杨氏模量（10.23 MPa）、粘接性、抗疲劳性（1000次循环）、可降解性和一定的自愈能力。这些性能与支链淀粉、聚丙烯酸和氯化胆碱通过氢键和静电相互作用产生的协同作用密切相关。通过改变淀粉含量可以调节共聚物的力学性能。基于共图的可穿戴传感器实现了对人体关节运动的准确、稳定的监测。该研究解决了传统水凝胶脱水和单一功能的局限性，为下一代柔性可穿戴设备的多功能生物基凝胶的开发提供了新的途径。

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引用次数: 0

Stretch-oriented chitosan/PVA-based anisotropic double network hydrogel curing by annealing and rehydration for wearable strain sensors 可穿戴应变传感器用拉伸取向壳聚糖/聚乙烯醇基各向异性双网水凝胶退火复水化固化

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-26 DOI: 10.1016/j.carbpol.2026.125014

Zijian Gao , Wenjun Kang , Xin Guan , Honglei Liu , Yihan Guo , Zichun Zhao , Yongqi Yang , Jian Sun , Hailun Ren , Zhaohui Jin

Conductive hydrogel is considered as ideal candidates for flexible electronic devices. However, the limited toughness, flexibility and swelling behavior of conductive hydrogel hinder their application in various environments. In this work, an anisotropic and swelling resistant hydrogel is developed by stretching and reorienting polymer chains by combining with annealing and rehydration process, which is inspired by hierarchical structure of natural tissues. As a result, this hydrogel exhibits significant variability in mechanical properties along and perpendicular to the orientation direction. The toughness along the orientation direction is 1018.5 ± 35.6 kJ·m⁻³ and the tearing energy is 0.56 ± 0.03 kJ·m⁻². The toughness perpendicular to the orientation direction is 483.4 ± 18.6 kJ·m⁻³ and the tearing energy is 2.24 ± 0.07 kJ·m⁻². The hydrophobic interactions of 2-hydroxyethyl methacrylate, in conjunction with the dense polymer network contribute to swelling resistant of the hydrogel. The anisotropic hydrogel is further integrated into flexible sensors, which could be capable of monitoring human motion in amphibious environments, providing distinctly different feedback signals in the directions parallel and perpendicular to the orientation. This work provides a promising strategy to prepare diverse anisotropic materials, offering new solutions for sensor technology.

导电水凝胶被认为是柔性电子器件的理想候选材料。然而，导电水凝胶有限的韧性、柔韧性和膨胀特性阻碍了其在各种环境中的应用。在本研究中，受自然组织分层结构的启发，通过拉伸和重定向聚合物链，结合退火和再水化过程，开发了一种各向异性和抗膨胀的水凝胶。因此，这种水凝胶在取向方向上和垂直方向上表现出显著的力学性能变化。取向方向韧性为1018.5±35.6 kJ·m−3，撕裂能为0.56±0.03 kJ·m−2。垂直于取向方向的韧性为483.4±18.6 kJ·m−3，撕裂能为2.24±0.07 kJ·m−2。2-羟乙基甲基丙烯酸酯的疏水相互作用与致密的聚合物网络相结合，有助于水凝胶的抗膨胀性。将各向异性水凝胶进一步集成到柔性传感器中，可以在两栖环境中监测人体运动，在平行和垂直方向上提供明显不同的反馈信号。这项工作为制备各种各向异性材料提供了一种有前途的策略，为传感器技术提供了新的解决方案。

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引用次数: 0

High-pressure solid-state (mechanochemistry) synthesis of corn starch tartrates 高压固态（机械化学）合成玉米淀粉酒石酸盐

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-26 DOI: 10.1016/j.carbpol.2026.125013

Diego E. Boldrini

In this work, native and pretreated corn starches were chemically modified to obtain starch tartrates, a derivative with potential use in a variety of food and non-food applications, such as biomedical, pharmaceutical, and environmental fields. The objective was to perform the synthesis by a novel solid-state methodology at high-pressure, varying the system pressure, temperature, and reaction time. Before the reactions, native starch was thermally pretreated in a water/propylene glycol medium to improve the esterification activity. The maximum degree of substitution (DS) reached (0.1718) was achieved using native pretreated starch at a pressure of 55 kg cm⁻², a temperature of 343 K, and a reaction time of 72 h. To characterize the derivatives obtained, several techniques were used, such as Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential thermogravimetry (DTG), differential scanning calorimetry (DSC), polarized light microscopy, and X-ray diffraction (XRD). The obtained results demonstrate that it is feasible to carry out the solid-state esterification of starches using a high-pressure system, achieving higher DS than the system at atmospheric pressure. Furthermore, starch pretreatment improves the reaction performance (up to 34% for the maximum DS) compared to that achieved using native starch.

在这项工作中，对天然和预处理的玉米淀粉进行化学改性以获得淀粉酒石酸盐，这种衍生物在各种食品和非食品应用中具有潜在的用途，例如生物医学，制药和环境领域。目的是通过一种新的固态方法在高压下进行合成，改变系统压力、温度和反应时间。在反应前，天然淀粉在水/丙二醇介质中进行热预处理，以提高酯化活性。在压力为55 kg cm−2，温度为343 K，反应时间为72 h的条件下，天然预处理淀粉获得了最大取代度（DS）（0.1718）。为了表征所获得的衍生物，使用了多种技术，如傅里叶变换红外光谱（FT-IR），扫描电子显微镜（SEM），热重分析（TGA），差示热重法（DTG），差示扫描量热法（DSC），偏光显微镜，和x射线衍射（XRD）。结果表明，在高压条件下进行淀粉的固态酯化反应是可行的，其DS高于常压条件下的酯化反应。此外，与使用天然淀粉相比，淀粉预处理提高了反应性能（最大DS可达34%）。

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引用次数: 0

Combination citric acid and phytic acid co-esterified starch derivative with cellulose acetate as a coating for formulating a full biomass-based slow-release urea fertilizer 柠檬酸和植酸共酯化淀粉衍生物与醋酸纤维素的组合作为涂层，用于配制全生物质基缓释尿素肥料

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-26 DOI: 10.1016/j.carbpol.2026.125015

Shijia Gu , Guohua Dong , Xiaoxiao Tan , Xinjia Zhang , Tianyuan Xiao , Chao Wang , Yushu Wang , Wenzhi Zhang

The development of coated slow-release fertilizers (SRF) utilizing low-cost and abundantly available biomass materials is still a significant challenge in sustainable agricultural production. Herein, based on the citric acid and phytic acid co-esterified natural starch (NS) derivatives (CAPAS) and cellulose acetate (CAc), a novel full biomass-based coated urea (CAPAS-CAc@urea) SRF was developed by utilizing multiple impregnation coating technology. The experimental results demonstrate that the synthesized CAPAS possesses higher hydrophobicity, film-forming ability, and a well-developed cross-linked network structure, ultimately leading to enhanced mechanical properties, hydrophobicity, and biodegradability of the CAPAS-CAc film. Importantly, the resulting CAPAS-CAc@urea SRF shows superior nutrient slow-release properties, endowing a cumulative N slow-release rate ∼ 77.5% (48 h) in water and ∼ 58.9% (29 d) in soil, which is approximately five times slower than that of uncoated urea. Kinetic fitting indicates that the N release of the prepared CAPAS-CAc@urea complies with the First-order kinetics model, which is governed by a Fickian diffusion mechanism. The results of the sugar sorghum pot experiment verify that CAPAS-CAc@urea exhibits the prominent function for promoting plant growth, primarily through improving root development. Consequently, this study provides a novel route for advancement of environmentally-friendly coated SRF with degradable biomass materials in the sustainable agriculture.

利用低成本和丰富的生物质材料开发包膜缓释肥料（SRF）仍然是可持续农业生产的重大挑战。本文以柠檬酸和植酸共酯化天然淀粉（NS）衍生物（CAPAS）和醋酸纤维素（CAc）为基础，利用多次浸渍包衣技术，研制了一种新型的全生物质包覆尿素（CAPAS-CAc@urea） SRF。实验结果表明，合成的CAPAS具有较高的疏水性、成膜能力和发育良好的交联网络结构，从而提高了CAPAS- cac膜的力学性能、疏水性和生物降解性。重要的是，所得CAPAS-CAc@urea SRF显示出优越的养分缓释特性，使氮素在水中的累积缓释率为~ 77.5% (48 h)，在土壤中的累积缓释率为~ 58.9% (29 d)，比未包膜尿素慢约5倍。动力学拟合表明，制备的CAPAS-CAc@urea的N释放符合一级动力学模型，受菲克扩散机制控制。糖高粱盆栽试验结果验证了CAPAS-CAc@urea主要通过促进根系发育表现出显著的促进植物生长的功能。因此，本研究为可持续农业中可降解生物质材料的环保型覆膜SRF的发展提供了一条新的途径。

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引用次数: 0

Starch as a designable platform for oral drug delivery: From structural modulation to application in inflammatory bowel disease 淀粉作为可设计的口服给药平台：从结构调节到炎症性肠病的应用

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-26 DOI: 10.1016/j.carbpol.2026.125019

Mengyuan Qin , Feng Jiang , Yan Hong , Lingjin Li , Yongmin Cui , Canran Jin , Zhengbiao Gu , Li Cheng , Zhaofeng Li , Caiming Li , Xiaofeng Ban

The effective management of inflammatory bowel disease (IBD) remains constrained by a central pharmaceutical challenge: achieving site-specific drug delivery to inflamed colonic mucosa while minimizing systemic exposure. Conventional oral formulations often suffer from off-target release and poor bioavailability, leading to suboptimal efficacy and systemic side effects. This review addresses this challenge by focusing on starch, a natural, biodegradable, and structurally versatile polysaccharide, as a foundational material for engineering intelligent colon-targeted carriers. It examines how the hierarchical architecture and tunable chemistry of starch enable the rational design of delivery systems capable of navigating the gastrointestinal tract. Specifically, it discusses chemical, physical, and enzymatic modification strategies that impart starch-based carriers with microenvironment-responsive behavior and active targeting toward overexpressed receptors. Beyond sophisticated targeting, the review critically analyzes how these designed starch-based oral delivery systems exert multi-mechanistic therapeutic effects, including reinforcing the epithelial barrier, restoring microbial homeostasis, and recalibrating immune responses. By synthesizing recent advances through a “structure-to-function” perspective, this work provides a strategic rationale for developing next-generation starch-based oral platforms aimed at precise, localized, and effective intervention in IBD.

炎症性肠病（IBD）的有效治疗仍然受到一个核心药物挑战的限制：实现部位特异性药物递送到发炎的结肠粘膜，同时最大限度地减少全身暴露。传统的口服制剂往往存在脱靶释放和生物利用度差的问题，导致疗效欠佳和全身副作用。这篇综述通过关注淀粉这种天然的、可生物降解的、结构多样的多糖，作为工程智能结肠靶向载体的基础材料来解决这一挑战。它研究了淀粉的层次结构和可调化学如何使能够导航胃肠道的输送系统的合理设计。具体来说，它讨论了化学、物理和酶修饰策略，赋予淀粉基载体微环境响应行为和对过表达受体的主动靶向。除了复杂的靶向治疗，这篇综述还批判性地分析了这些设计的基于淀粉的口服给药系统如何发挥多机制的治疗效果，包括加强上皮屏障、恢复微生物稳态和重新校准免疫反应。通过从“结构到功能”的角度综合最近的进展，这项工作为开发下一代基于淀粉的口服平台提供了战略依据，旨在精确、局部和有效地干预IBD。

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引用次数: 0

Cold plasma-assisted processing: A sustainable route to high-quality chitosan from crab shells 冷等离子体辅助加工：从蟹壳中获得高质量壳聚糖的可持续途径

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-25 DOI: 10.1016/j.carbpol.2026.125008

Zhicheng Cai , Jianfeng Lu , Qiang Li , Qingli Han , Yuan Song , Lin Lin , Chenghui Wang , Bin Zheng , Xiangzhao Mao , Changhu Xue

Traditional chitosan production, involving chitin extraction and deacetylation, relies on harsh high-alkali chemical processing, which raises safety and sustainability concerns. This study proposes an atmospheric-pressure plasma pretreatment strategy to enhance deacetylation efficiency and structural quality during the alkaline deacetylation of chitin extracted from crab shells to produce chitosan. Comprehensive characterisation using Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy and molecular weight analysis reveal that plasma selectively etches the amorphous domains and weakens glycosidic linkages, thereby improving mass-transfer efficiency during deacetylation. Under 40–50% NaOH, plasma-treated samples achieve markedly higher deacetylation degrees (PAW post-processing: 65–74%) than those of the conventional method (traditional chemical method: 58–67%), together with higher crystallinity (up to 31.18%) and enhanced thermal stability. These molecular and interfacial modifications collectively enhance antibacterial performance, enlarging inhibition zones against Staphylococcus aureus and Pseudomonas aeruginosa to 14.57 ± 0.45 mm and 14.16 ± 0.06 mm, respectively. Overall, plasma pretreatment is an environmentally benign and structurally beneficial approach for producing high-performance chitosan from crab shells.

传统的壳聚糖生产，包括甲壳素提取和去乙酰化，依赖于苛刻的高碱化学处理，这引起了安全性和可持续性问题。本研究提出常压等离子体预处理策略，以提高蟹壳中甲壳素碱性去乙酰化制备壳聚糖的效率和结构质量。利用傅里叶变换红外光谱、质子核磁共振、x射线衍射、差示扫描量热法、热重分析、扫描电镜、原子力显微镜、x射线光电子能谱和分子量分析等综合表征表明，等离子体选择性地蚀刻了非晶态结构域，削弱了糖苷键，从而提高了脱乙酰过程中的传质效率。在40-50%的NaOH条件下，等离子体处理样品的去乙酰化程度（PAW后处理：65-74%）明显高于传统方法（传统化学方法：58-67%），结晶度更高（高达31.18%），热稳定性增强。这些分子修饰和界面修饰共同增强了抗菌性能，将对金黄色葡萄球菌和铜绿假单胞菌的抑制区分别扩大到14.57±0.45 mm和14.16±0.06 mm。总之，等离子体预处理是一种环境友好、结构有利的蟹壳制备高性能壳聚糖的方法。

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引用次数: 0

Research progress and future prospects of cellulose-based composite gas separation membranes from a green sustainability perspective 绿色可持续性视角下纤维素基复合气体分离膜的研究进展与展望

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-25 DOI: 10.1016/j.carbpol.2026.124995

Han Pei , Jinghui Zhou , Hongge Jia , Chengbao Geng , Mingyu Zhang , Yanqing Qu , Shuangping Xu , Xiaozhou Zhang , Xing Wang , Jingyu Xu

Gas separation membrane technology, renowned for its low energy consumption and strong environmental compatibility, is progressively replacing traditional high‑carbon separation processes, becoming a central focus in the field of green separation. Cellulose-based membranes, characterized by their renewability, biodegradability, and low toxicity, have emerged as the preferred materials for the new generation of sustainable separation membranes. In the separation of critical gas pairs such as CO₂/N₂ and O₂/N₂, these materials exhibit an excellent balance between permeability and selectivity, combining practical utility with environmental benefits. This paper reviews recent advances in cellulose-based composite gas separation membranes, emphasizing performance optimization by systematically evaluating the permeability-selectivity trade-off in key gas separations. It explores key optimization strategies, including filled composites and chemical surface functionalization. Optimized cellulose-based composite membranes demonstrate significant improvements in both gas selectivity and permeability. Finally, this paper summarizes current challenges in the field and outlines future research directions, highlighting that the importance of cellulose-based gas separation membranes extends beyond single-material optimization. Grounded in green chemistry principles, this technology is emerging as a crucial link connecting fundamental research, industrial transformation, and national strategy through technological breakthroughs and cross-scenario applications.

气体分离膜技术以其低能耗和强环境相容性而闻名，正逐步取代传统的高碳分离工艺，成为绿色分离领域的焦点。纤维素基膜具有可再生性、可生物降解性和低毒性等特点，已成为新一代可持续分离膜的首选材料。在CO₂/N₂和O₂/N₂等关键气体对的分离中，这些材料在渗透性和选择性之间表现出良好的平衡，将实用性与环境效益相结合。本文综述了纤维素基复合气体分离膜的最新进展，强调通过系统地评估关键气体分离中的渗透选择性权衡来优化性能。它探讨了关键的优化策略，包括填充复合材料和化学表面功能化。优化后的纤维素基复合膜在气体选择性和透气性方面都有显著改善。最后，本文总结了该领域目前面临的挑战，并概述了未来的研究方向，强调纤维素基气体分离膜的重要性超越了单一材料的优化。该技术基于绿色化学原理，通过技术突破和跨场景应用，正在成为连接基础研究、产业转型和国家战略的关键环节。

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引用次数: 0

Natural small molecule-polysaccharide nanoparticles: Preparation, characteristics-efficacy modulation, and drug delivery applications 天然小分子多糖纳米颗粒：制备、特性、功效调节和药物传递应用

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers

Pub Date : 2026-01-25 DOI: 10.1016/j.carbpol.2026.125010

Weiyi Zhao , Weiqiang Huang , Xipei Wu , Xia Li , Wenyuan Gao , Lanping Guo

The rapid advancement of nanotechnology is revolutionizing fields like biology and materials science. However, concerns over the environmental and health impacts of conventional nanomaterials have spurred interest in sustainable alternatives. Natural small molecule-polysaccharide nanoparticles (NSM-PSNPs), synthesized from biocompatible and biodegradable polysaccharides and bioactive natural small molecules (NSMs), present a promising solution. These composite nanoparticles exhibit significant synergistic effects, enhancing the delivery, oral absorption, bioavailability, and controlled release of NSMs for therapeutic and other applications. Despite considerable progress, challenges remain in precisely controlling their structure-property relationships and understanding their behavior in complex biological environments. This review aims to address these challenges by providing strategic design principles for ideal NSM-PSNPs. It systematically outlines the classifications and properties of polysaccharides and NSMs, discusses assembly techniques for NSM-PSNPs, and analyzes the critical correlation between their characteristics and efficacy. Furthermore, the review examines key parameters affecting NSM-PSNPs properties to guide accurate control and explores their diverse applications, with a focus on drug delivery. Finally, it concludes by summarizing current challenges and future prospects in the development and application of NSM-PSNPs.

纳米技术的迅速发展正在给生物学和材料科学等领域带来革命性的变化。然而，对传统纳米材料对环境和健康影响的担忧激发了人们对可持续替代品的兴趣。天然小分子多糖纳米粒子（NSM-PSNPs）是由生物相容性和可生物降解的多糖和具有生物活性的天然小分子（NSMs）合成的，是一种很有前景的解决方案。这些复合纳米颗粒表现出显著的协同效应，增强了nsm的递送、口服吸收、生物利用度和控释，用于治疗和其他应用。尽管取得了相当大的进展，但在精确控制它们的结构-性质关系和理解它们在复杂生物环境中的行为方面仍然存在挑战。本文旨在通过提供理想的nsm - psnp的战略设计原则来解决这些挑战。系统地概述了多糖和nsm的分类和性质，讨论了nsm - psnp的组装技术，并分析了它们的特性与功效之间的关键相关性。此外，本文还研究了影响nsm - psnp特性的关键参数，以指导精确控制，并探讨了它们在药物传递方面的不同应用。最后，总结了nsm - psnp在开发应用中面临的挑战和未来的发展前景。

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引用次数: 0