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Vitamin A for the Prevention of Renal Parenchymal Injury in Children With Acute Pyelonephritis: An assessor-blind Randomized Controlled Trial 维生素A预防儿童急性肾盂肾炎肾实质损伤:一项评估盲随机对照试验
Pub Date : 2022-10-10 DOI: 10.34172/hmj.2022.33
K. Ghasemi, Maryam Esteghamati, Seyed Mahmood Ahmadi Koupaie
Background: To date, limited studies have evaluated the role of vitamin A in acute pyelonephritis (APN). Accordingly, we aimed to investigate the effect of this vitamin on the prevention of renal damage in children with APN. Methods: This assessor-blind randomized controlled trial included 108 children with APN, aged 3 months to 14 years, who were admitted to Bandar Abbas Children’s Hospital, Bandar Abbas, Iran, in 2020. Patients were randomly allocated to two equal groups. Children in the vitamin A group received vitamin A in addition to antibiotics (ceftriaxone), while those in the control group only received antibiotics. Then, children in both groups underwent dimercaptosuccinic acid (DMSA) scanning once at baseline and four months after treatment. Photopenic areas in the DMSA scan were regarded as damaged areas. Further, serum vitamin A levels, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate (ESR) were measured in all participants before the initiation of treatment. Finally, the demographic features of the participants were noted, including age and gender. Results: Patients in both groups were comparable regarding age and sex. Serum vitamin A levels, CRP, and ESR did not differ significantly between groups before treatment. The mean number of photopenic areas in the baseline DMSA scan was similar in both groups (P=0.481); however, the mean number of photopenic areas in the DMSA scan after four months was significantly lower in the vitamin A group compared to controls (P=0.004). Conclusion: Therefore, the use of vitamin A, along with antibiotics can significantly decrease renal damage in children with APN.
背景:迄今为止,有限的研究评估了维生素A在急性肾盂肾炎(APN)中的作用。因此,我们旨在研究这种维生素对预防APN患儿肾脏损害的作用。方法:本评估盲随机对照试验纳入108例APN患儿,年龄3个月至14岁,于2020年在伊朗阿巴斯港阿巴斯市儿童医院住院。患者被随机分为两组。维生素A组的儿童在服用抗生素(头孢曲松)的同时服用维生素A,而对照组的儿童只服用抗生素。然后,两组儿童在基线和治疗后4个月分别进行一次二巯基琥珀酸(DMSA)扫描。DMSA扫描中的光敏区视为损伤区。此外,在治疗开始前测量所有参与者的血清维生素A水平、c反应蛋白(CRP)水平和红细胞沉降率(ESR)。最后,注意到参加者的人口特征,包括年龄和性别。结果:两组患者在年龄和性别方面具有可比性。治疗前两组间血清维生素A水平、CRP和ESR无显著差异。两组基线DMSA扫描的平均失光区数相似(P=0.481);然而,与对照组相比,维生素A组4个月后DMSA扫描中的平均失光区数量显著降低(P=0.004)。结论:维生素A联合抗生素可显著降低APN患儿肾脏损害。
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引用次数: 0
Resistance to COVID-19 Vaccine in Medical Students 医学生对COVID-19疫苗的耐药性
Pub Date : 2022-10-10 DOI: 10.34172/hmj.2022.39
F. Bagheri Sheykhangafshe, H. Farahani, A. Fathi-Ashtiani
During the spread of coronavirus disease 2019 (COVID-19), the number of casualties increased, and strict measures such as closing schools and universities were taken to curb the spread of the disease in various parts of the world. Many students were taking virtual classes for the first time and had not experienced such a pandemic, which led to significant fear and stress in them (1). On the other hand, being in an environment contaminated with COVID-19 has caused widespread psychological disorders such as anxiety, depression, stress, and sleep problems in many students (2). Medical and paramedical students, in particular, experienced significant stress during the outbreak due to academic stress, exposure to infection and contamination, networking, and lack of sleep, which affected their mental health (3). During the COVID-19 pandemic, medical students who underwent internships in hospitals were at higher risk for infection because they were in COVID19-contaminated environments. This led to increased stress and anxiety for these students compared to other students. On the other hand, many medical students were afraid of contracting COVID-19 in the hospital setting and transmitting it to their family and relatives as an asymptomatic carrier (4). The lack of an effective vaccine or an effective treatment alternative for the treatment of COVID-19 has become a difficult challenge in all countries worldwide. Although several solutions were tried in this regard, including home quarantine, social distancing, masking, and controlling the prevalence of COVID-19, the global COVID-19 pandemic cannot be expected to significantly decrease until an effective and efficient vaccine is developed against this new virus (5). Finally, after much effort, the FDA licensed the Pfizer-BioNTech vaccine on December 11 and the modern one on December 18. According to studies, these two vaccines are 95% effective against COVID-19 for people over 16 years of age (6). However, public vaccination cannot be guaranteed even after public access to safe vaccines because we are facing resistance to vaccination (7). Resistance to various vaccines has been widely observed throughout medical history and is not a new phenomenon. Considering that previous research has shown that adaptation to vaccines is variable and contradictory, achieving public acceptance requires extensive training in the safety and efficacy of different vaccines (8). In fact, it should be noted that all vaccines challenge the immune system and increase inflammatory markers within a few hours of vaccination, as well as in people with severe allergies. Vaccination causes unusual reactions, thus the medical record of individuals should be examined before starting universal vaccination (9). To prevent the spread of COVID-19, high-risk groups such as hospital staff and medical students should be given priority over the COVID-19 vaccine. However, medical students may not be accepted for the COVID-19 vaccine for various re
在2019冠状病毒病(COVID-19)传播期间,伤亡人数不断增加,各国采取了关闭学校和大学等严格措施,遏制了疾病在世界各地的传播。许多学生是第一次上虚拟课程,没有经历过这样的大流行,这导致了他们的巨大恐惧和压力(1)。另一方面,在被COVID-19污染的环境中,许多学生造成了广泛的心理障碍,如焦虑、抑郁、压力和睡眠问题(2)。特别是医学和医学生,在疫情期间由于学业压力而承受了巨大的压力。暴露于感染和污染、网络和睡眠不足,这些都影响了他们的心理健康(3)。在COVID-19大流行期间,在医院实习的医学生感染的风险更高,因为他们处于被COVID-19污染的环境中。与其他学生相比,这导致这些学生的压力和焦虑增加。另一方面,许多医学生害怕在医院感染COVID-19并将其作为无症状携带者传播给家人和亲属(4)。缺乏有效的疫苗或有效的治疗替代方案已成为世界各国面临的难题。尽管在这方面尝试了几种解决方案,包括家庭隔离、社交距离、口罩和控制COVID-19的流行,但在开发出针对这种新病毒的有效和高效疫苗之前,全球COVID-19大流行无法预期显着减少(5)。最终,经过诸多努力,FDA于12月11日批准了辉瑞- biontech疫苗,并于12月18日批准了现代疫苗。根据研究,这两种疫苗对16岁以上人群的COVID-19有效率为95%(6)。然而,即使在公众获得安全疫苗之后,也不能保证公众接种疫苗,因为我们面临着疫苗接种耐药性(7)。在整个医学史上,对各种疫苗的耐药性已经广泛观察到,并不是一个新现象。考虑到先前的研究表明,对疫苗的适应是可变的和矛盾的,要想让公众接受,需要对不同疫苗的安全性和有效性进行广泛的培训(8)。事实上,应该注意的是,所有疫苗在接种后的几个小时内都会挑战免疫系统,增加炎症标志物,对严重过敏的人群也是如此。接种疫苗会引起异常反应,因此在开始普遍接种疫苗之前应检查个人的医疗记录(9)。为防止COVID-19的传播,应优先考虑医院工作人员和医学生等高危人群,而不是COVID-19疫苗。然而,由于各种原因,医学生可能不被接受接种COVID-19疫苗(10)。在一项类似的研究中,Saied等人(8)调查了医学生对COVID-19疫苗的耐药性,发现90.5%的学生理解疫苗接种的重要性,46%的学生持怀疑态度。学生最关心的问题是疫苗的副作用(96.8%)和无效(92.3%)。在另一项研究中,Jain等(10)评估了印度医学生对COVID-19疫苗的耐药性,报告10.6%的学生对接种COVID-19疫苗犹豫不决。对疫苗的安全性和有效性的担忧,缺乏意识,以及对政府的低信任度是导致他们抵制的因素之一。同样,Chijoke等人(7)研究了医学生对乙肝和COVID-19疫苗的信心。结果显示,39%和14.7%的学生分别担心接种新冠病毒疫苗和乙型肝炎疫苗。此外,69.9%的医学生对新冠疫苗的安全性和有效性水平持怀疑态度。在2019冠状病毒病全球爆发18个月后,这种致命病毒继续变异并变得更加强大,无法确定冠状病毒后时期的具体日期。为此,人们必须信任他们的政府,医学生对COVID-19疫苗的抵抗力
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引用次数: 0
Epidemiology of COVID-19 in Kish Island from February to August 2020 2020年2月至8月基什岛COVID-19流行病学分析
Pub Date : 2022-10-10 DOI: 10.34172/hmj.2022.36
Elham Mansoorabadi, Maryam Sattarian, Mohammad Reza Rezania, E. Moradi, Mohammad Shamsadiny
Background: In March 2020, the world health organization declared the outbreak of novel coronavirus disease 2019 (COVID-19) as a pandemic. COVID-19 is a highly contagious disease. Kish is a touristic island that is located in the south of Iran. The aim of the present study was to investigate the epidemiology of COVID-19 on Kish island. Methods: In the present cross-sectional study, the residents of Kish Island, Iran, who were checked with COVID-19 polymerase chain reaction (PCR) test from February to August 2020 were included. The PCR test was obtained from symptomatic individuals or those people who had exposure to suspected COVID-19 cases. Data were collected from their medical records and analyzed based on their PCR test results. Results: A total of 4859 individuals were checked with COVID-19 PCR test. The result was positive in 1251 (25.75%) cases and negative in 3608 (74.25%). The mean age was 37.32 years. The majority of the individuals were men. Most of the participants were office employees. The number of housewives was approximately double in COVID-19 positive patients compared with the patients with negative results. About 40% of the individuals with positive results had a history of exposure to suspected COVID-19 cases. The prevalence of exposure to suspected COVID-19 cases and recent travel was significantly higher among positive cases (P<0.001). There was a significant correlation between the delay between the onset of the symptoms and performing PCR. Longer delays were seen among the deceased patients. Conclusion: It seems that more precise policies should be taken to avoid contact with symptomatic patients and people who had a history of travel to the island.
背景:2020年3月,世界卫生组织宣布2019年新型冠状病毒病(COVID-19)爆发为大流行。COVID-19是一种高度传染性疾病。基什岛是一个旅游岛屿,位于伊朗南部。本研究的目的是调查基什岛COVID-19的流行病学。方法:本横断面研究纳入2020年2月至8月在伊朗基什岛进行新冠病毒聚合酶链反应(PCR)检测的居民。PCR检测来自有症状的个体或与疑似COVID-19病例接触的人。从他们的病历中收集数据,并根据PCR检测结果进行分析。结果:共检测4859例。阳性1251例(25.75%),阴性3608例(74.25%)。平均年龄37.32岁。其中大多数是男性。大多数参与者都是办公室职员。与阴性患者相比,阳性患者的家庭主妇人数约为两倍。约40%的阳性结果患者有与疑似COVID-19病例的接触史。与疑似COVID-19病例接触和近期旅行的流行率在阳性病例中显著高于阴性病例(P<0.001)。在症状发作和进行PCR之间的延迟之间存在显著的相关性。死亡患者的延迟时间较长。结论:应采取更严格的措施,避免与有症状的患者和有赴岛旅行史的人员接触。
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引用次数: 0
The Effectiveness of Music Therapy on Anxiety, Self-esteem, and Social Adjustment of Children With Cancer in Kerman 音乐治疗对克尔曼地区癌症儿童焦虑、自尊及社会适应的影响
Pub Date : 2022-10-10 DOI: 10.34172/hmj.2022.31
Elham Momeni Gazestan, A. Heidarei, B. Makvandi, F. Moradimanesh
Background: Cancer is the second largest cause of child mortality after accidents worldwide. Childhood cancers have an average incidence in Iran, with 176 cases in one million people. The objective of this study was to examine the efficacy of music therapy on anxiety, self-esteem, and social adjustment of children with cancer in Kerman in 2019. Methods: A quasi-experimental method with a pre-test and post-test design with a control group was used in this study. The statistical population of research included all children with cancer admitted to Afzalipour hospital in Kerman (Iran) in 2019, and thirty children were selected by the convenience sampling method and then randomly divided into experimental (n=15) and control (n=15) groups. Data were collected using the children’s Multidimensional Anxiety Scale, the Coopersmith Self-esteem Inventory, and California Social Adjustment Scale. Finally, the data were analyzed using SPSS22 through the multivariate analysis of covariance. Results: The results indicated that music therapy was effective in reducing anxiety (P<0.001, F=179.29) while increasing self-esteem (P=0.001, F=120.60) and social adjustment (P=0.001, F=48.56) in children with cancer. Conclusion: It can be argued that music therapy in children with cancer has been successful for anxiety, self-esteem, and social adjustment and can be applied to alleviate psychological issues in children with cancer
背景:癌症是全世界儿童死亡的第二大原因,仅次于意外事故。伊朗儿童癌症的平均发病率为每100万人中有176例。本研究的目的是研究2019年克尔曼癌症儿童的音乐治疗对焦虑、自尊和社会适应的影响。方法:采用准实验方法,采用前测和后测设计,并设对照组。研究统计人群为伊朗克尔曼市Afzalipour医院2019年收治的所有癌症患儿,采用方便抽样法选取30名患儿,随机分为实验组(n=15)和对照组(n=15)。使用儿童多维焦虑量表、库珀史密斯自尊量表和加州社会适应量表收集数据。最后,通过协方差多变量分析,采用SPSS22对数据进行分析。结果:音乐治疗能有效降低癌症患儿的焦虑(P<0.001, F=179.29),提高自尊(P=0.001, F=120.60)和社会适应(P=0.001, F=48.56)。结论:音乐治疗在癌症患儿的焦虑、自尊和社会适应方面取得了成功,可以应用于缓解癌症患儿的心理问题
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引用次数: 1
The Effect of Zinc Supplementation on the Treatment of Neonatal Sepsis: A Randomized Controlled Trial 补充锌对新生儿脓毒症治疗的影响:一项随机对照试验
Pub Date : 2022-10-10 DOI: 10.34172/hmj.2022.37
S. Saadat, Rakhshaneh Goodarzi, Simin Yazdi, S. Zare
Background: Zinc plays an important role in some metabolic and signaling pathways of the immune system and may improve the signs and symptoms of neonatal sepsis. This study aimed to evaluate the efficacy of zinc supplementation in neonatal sepsis. Methods: This randomized controlled trial included 50 neonates with sepsis admitted to Bandar Abbas Children’s hospital, Iran, from 2018 to 2019. Patients were randomly allocated into two groups: the zinc group received standard antibiotics plus 1 mg/kg zinc gluconate twice a day for 7 days starting within the first 24 hours after admission, while the control group only received antibiotics. Complete blood count (CBC) with differential, C-reactive protein (CRP), and platelets were measured on the first day of admission. Blood sampling was done again after 48 hours based on the patients’ condition. Patients’ information such as age, sex, gestational age, birth weight, time to the improvement of clinical and laboratory findings, hospital length of stay, mortality, change in the antibiotic regimen, and signs of sepsis were noted. Results: The two study groups were similar concerning age and sex. Birth weight, gestational age, duration of hospital stay, time to the improvement of clinical findings, baseline CRP, and change in the antibiotic regimen were comparable in both groups (P>0.05). The time to the improvement of laboratory findings was significantly lower with zinc supplementation compared with controls (6.56±2.95 vs. 8.36±3.34 days, P=0.022). Further, final CRP significantly decreased compared to baseline CRP in both groups (P<0.001); however, this reduction was greater in the zinc group (final CRP: 3.60±1.87 vs. 5.12±2.11 mg/L, P=0.015). Moreover, no mortality was reported in either of the groups. Conclusion: Zinc supplementation had no effect on hospital length of stay in neonatal sepsis; however, it reduced the time to the improvement of laboratory findings, especially CRP.
背景:锌在免疫系统的一些代谢和信号通路中起重要作用,并可能改善新生儿败血症的体征和症状。本研究旨在评估锌补充剂对新生儿败血症的疗效。方法:本随机对照试验纳入2018年至2019年伊朗阿巴斯港儿童医院收治的50例脓毒症新生儿。患者随机分为两组:锌组在入院后24小时内给予标准抗生素加葡萄糖酸锌1 mg/kg,每天2次,连续7天;对照组仅给予抗生素。在入院第一天测量全血细胞计数(CBC)、c反应蛋白(CRP)和血小板。48小时后根据患者情况再次采血。患者的信息,如年龄、性别、胎龄、出生体重、临床和实验室结果改善所需时间、住院时间、死亡率、抗生素治疗方案的变化和败血症的迹象被记录下来。结果:两组患者年龄、性别相近。两组患者的出生体重、胎龄、住院时间、临床表现改善时间、基线CRP和抗生素治疗方案的变化具有可比性(P>0.05)。与对照组相比,补锌组改善实验室检查结果所需时间显著缩短(6.56±2.95∶8.36±3.34天,P=0.022)。此外,与基线CRP相比,两组的最终CRP显著降低(P<0.001);然而,锌组的这种降低更大(最终CRP: 3.60±1.87比5.12±2.11 mg/L, P=0.015)。此外,两组均无死亡报告。结论:补锌对新生儿败血症住院时间无影响;然而,它减少了改善实验室结果的时间,特别是CRP。
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引用次数: 0
The Effectiveness of Acceptance and Commitment Therapy and Mindfulness-Based Cognitive Therapy on Illness Perception and Adherence to the Treatment of Patients With Multiple Sclerosis 接受承诺疗法和正念认知疗法对多发性硬化症患者疾病感知和依从性的影响
Pub Date : 2022-10-10 DOI: 10.34172/hmj.2022.32
P. Sami, Suzan Emamipoor, A. Rafiepoor
Background: Multiple sclerosis (MS) is a common disease of the central nervous system. The main cause of this disease is related to the myelin damage of nerve cells. This study aimed to compare the effectiveness of acceptance and commitment therapy (ACT) and mindfulness-based cognitive therapy (MBCT) on illness perception and adherence to the treatment of patients with MS. Methods: This is a quasi-experimental study with a pre-test, post-test, and follow-up design with a control group. The statistical population of this study included all patients with MS under the auspices of the MS Society of Tehran (Iran) in 2019. Forty-five women with MS were purposefully selected and randomly divided into MBCT, ACT, and control (n=15) groups. Data were obtained using the revised illness perception questionnaire (IPQ-R) and the MS treatment adherence questionnaire (MS-TAQ). The repeated measurement analysis of variance and SPSS.22 were used to analyze data. Results: The results showed that the effect of MBCT was greater than that of the acceptance and commitment-based therapy group on illness perceptions (P<0.001) and treatment adherence (P<0.001). Conclusion: Overall, the effectiveness of MBCT was greater than that of the ACT group on illness perceptions and adherence to treatment. MBCT and ACT can be employed as effective methods for patients with MS.
背景:多发性硬化症(MS)是一种常见的中枢神经系统疾病。本病的主要病因与神经细胞髓鞘损伤有关。本研究旨在比较接受与承诺疗法(ACT)和正念认知疗法(MBCT)对多发性硬化症患者疾病感知和治疗依从性的影响。方法:采用准实验研究,采用前测、后测和随访设计,并以对照组为研究对象。本研究的统计人群包括2019年德黑兰MS协会(伊朗)赞助的所有MS患者。有目的地选择45名MS女性,随机分为MBCT组、ACT组和对照组(n=15)。采用修订后的疾病感知问卷(IPQ-R)和MS治疗依从性问卷(MS- taq)获得数据。采用重复测量方差分析和SPSS.22进行数据分析。结果:MBCT对患者疾病认知和治疗依从性的影响大于接受性和承诺性治疗组(P<0.001)。结论:总体而言,MBCT在疾病认知和治疗依从性方面的有效性大于ACT组。MBCT和ACT是治疗多发性硬化症的有效方法。
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引用次数: 0
Association of Emotional and Cognitive Intimacy With Promiscuous Married Men Through Mediating Role of Attitude Towards Infidelity 情感和认知亲密关系对滥交已婚男性不忠态度的中介作用
Pub Date : 2022-09-23 DOI: 10.34172/hmj.2023.5131
Kimia Zarei, M. Shahbazi, A. Koraei
Background: Promiscuity and attitude towards infidelity can harm family health and cause many family problems. They are also two important reasons for divorce and separation. This study aimed to investigate the association of emotional and cognitive intimacy with promiscuity through the mediating role of attitude towards infidelity in married men. Methods: This applied descriptive study had a correlational design and adopted the structural equation modeling method. The statistical population included all married men in Bushehr (Iran) who visited marriage counseling centers in 2020. A total of 384 married men were selected as the sample using convenience sampling. The research tools included the Personal Assessment of Intimacy in Relationships, Attitudes towards Infidelity Scale, and the Justifications for Extramarital Relationships. Data were analyzed via the Pearson correlation method and structural equation modeling. SPSS version-24 and AMOS-24 were further used for analyzing the data. Results: The results indicated that there was a direct association between emotional intimacy and attitude towards infidelity (β=0.18, P=0.001), cognitive intimacy and attitude towards infidelity (β=-0.62, P=0.001), emotional intimacy and promiscuity (β=0.11, P=0.014), attitude towards infidelity and promiscuity (β=0.68, P=0.001), but there was no a significant association between cognitive intimacy and promiscuity. The findings also revealed a significant relationship of emotional (β=0.19, P=0.009) and cognitive (β=-0.39, P=0.007) intimacy and promiscuity with mediating role of attitude towards infidelity in men. Conclusion: In general, this study revealed that emotional-cognitive intimacy is a predictor of promiscuity. Therefore, the findings can contribute to studies that lead to marital stability.
背景:滥交和对待不忠的态度会损害家庭健康,造成许多家庭问题。这也是离婚和分居的两个重要原因。本研究旨在通过对不忠态度的中介作用,探讨已婚男性情感和认知亲密行为对滥交的影响。方法:应用描述性研究进行相关设计,采用结构方程建模方法。统计人口包括2020年在布什尔(伊朗)访问婚姻咨询中心的所有已婚男性。采用方便抽样法,选取384名已婚男性作为样本。研究工具包括个人亲密关系评估量表、不忠态度量表和婚外恋正当性量表。通过Pearson相关法和结构方程模型对数据进行分析。进一步采用SPSS version-24和AMOS-24对数据进行分析。结果:情感亲密度与不忠态度(β=0.18, P=0.001)、认知亲密度与不忠态度(β=-0.62, P=0.001)、情感亲密度与滥交(β=0.11, P=0.014)、不忠态度与滥交(β=0.68, P=0.001)存在直接相关,但认知亲密度与滥交无显著相关。研究结果还揭示了情感(β=0.19, P=0.009)和认知(β=-0.39, P=0.007)亲密行为和滥交行为在男性不忠态度中的中介作用。结论:总的来说,本研究揭示了情感-认知亲密关系是滥交的预测因子。因此,这些发现有助于研究婚姻的稳定性。
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引用次数: 0
The Effect of Topical Diltiazem on Post-Hemorrhoidectomy Pain: A Cohort Study 外用地尔硫卓对痔切除术后疼痛的影响:一项队列研究
Pub Date : 2022-08-14 DOI: 10.34172/hmj.2023.8168
Mehrdad Sayadinia, Ali Hadavandkhani, Mahan Sayadinia
Background: Diltiazem is a calcium channel blocker that can prevent calcium absorption by myocytes and decrease the tone of the internal anal sphincter. Thus, it can be used for the treatment of anal fissures; however, its effect on post-hemorrhoidectomy pain is unclear. Accordingly, the current study aimed to evaluate the effect of topical diltiazem on post-hemorrhoidectomy pain. Methods: This cohort study included 50 candidates of hemorrhoidectomy referred to Shahid Mohammadi Hospital, Bandar Abbas, Iran from March 20, 2020, to March 21, 2021. First, the characteristics of the patients, including age, gender, degree of hemorrhoid, and the number of hemorrhoid pockets were recorded based on the study purpose. One group received topical diltiazem 2% three times a day for three days after hemorrhoidectomy, and the other group received Vaseline®. Both groups also received 500 mg paracetamol tablets. Post-hemorrhoidectomy pain was assessed using a numerical rating scale (NRS) by patients on the first and third days after surgery. The cumulative amount of consumed paracetamol was also noted on the third day. Results: Patients in both groups were comparable regarding age, gender, degree of hemorrhoids, and the number of pockets. There was no significant difference between groups in terms of pain on the first day after surgery (P=0.626), while the mean pain score was significantly lower in the diltiazem group on the third day compared to the placebo group (P<0.001). Finally, the cumulative amount of consumed paracetamol was significantly higher in the placebo group (P=0.001). Conclusion: Overall, topical diltiazem appears to be more effective than placebo for post-hemorrhoidectomy pain reduction.
背景:地尔硫卓是一种钙通道阻滞剂,可阻止肌细胞吸收钙,降低肛门内括约肌的张力。因此,它可用于治疗肛裂;然而,它对痔切除术后疼痛的影响尚不明确。因此,本研究旨在评估外用地尔硫卓对痔切除术后疼痛的影响。研究方法这项队列研究纳入了 2020 年 3 月 20 日至 2021 年 3 月 21 日期间转诊至伊朗阿巴斯港沙希德-穆罕默迪医院的 50 名痔切除术候选人。首先,根据研究目的记录患者的特征,包括年龄、性别、痔疮程度和痔袋数量。在痔疮切除术后,一组接受 2% 地尔硫卓外用药,每天三次,连续三天;另一组接受凡士林®外用药。两组还都服用了 500 毫克扑热息痛片。患者在术后第一天和第三天使用数字评分量表(NRS)对痔切除术后疼痛进行评估。第三天还记录了扑热息痛的累计用量。结果两组患者的年龄、性别、痔疮程度和痔袋数量相当。两组患者术后第一天的疼痛无明显差异(P=0.626),而第三天地尔硫卓组的平均疼痛评分明显低于安慰剂组(P<0.001)。最后,安慰剂组的扑热息痛累计用量明显更高(P=0.001)。结论总体而言,外用地尔硫卓在减轻痔切除术后疼痛方面似乎比安慰剂更有效。
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引用次数: 1
The Effectiveness of Lazarus Multimodal Approach on Psychological Distress, Working Memory, and Anxiety in Patients With Multiple Sclerosis 拉撒路多模式治疗对多发性硬化症患者心理困扰、工作记忆和焦虑的影响
Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.20
Soha Shahlapour, M. Sedaghat, Sara Pashang
Background: Multiple sclerosis (MS) is considered a chronic disease in which physical and mental disorders are common among these patients. This study aimed to evaluate the effectiveness of the Lazarus multimodal approach intervention on psychological distress, working memory, and anxiety in patients with MS. Methods: A quasi-experimental research method with pre-test, post-test, and follow-up and a control group was used in this study. The statistical population of the study included the patients who were members of the "MS Patient Support Society" in Tehran who had been referred to this center during January and March 2017. The sample consisted of 32 people selected by the convenience sampling method from the members of the MS community. The data were obtained through the Kessler psychological distress scale (K10), the Wechsler’s Working Memory Index, and the Beck Anxiety Inventory. The experimental group underwent the Lazarus multimodal approach in ten 90-minute sessions of two sessions per week for one and a half months. The control group received no intervention. The follow-up was performed three months after the post-test. The repeated measurement method and SPSS 22 were used to analyze the data. Results: The findings showed that the Lazarus multimodal approach had a significant effect on decreasing anxiety (P<0.001), psychological distress (P<0.001), and increasing working memory (P<0.001). Conclusion: It can be concluded that Lazarus’ multimodal approach was effective on anxiety, psychological distress, and working memory and can be employed to reduce psychological problems in patients with MS.
背景:多发性硬化症(MS)被认为是一种慢性疾病,在这些患者中,身体和精神障碍是常见的。本研究旨在评价拉撒路多模态方法对多发性硬化症患者心理困扰、工作记忆和焦虑的干预效果。方法:采用前测、后测、随访和对照组相结合的准实验研究方法。该研究的统计人群包括2017年1月至3月期间转介到该中心的德黑兰“MS患者支持协会”成员。样本采用方便抽样法从MS社区成员中抽取32人。数据通过Kessler心理困扰量表(K10)、Wechsler工作记忆指数和Beck焦虑量表获得。实验组接受了拉撒路多模式方法,每周两次,每次90分钟,持续一个半月。对照组不进行干预。随访时间为后测后3个月。采用重复测量法和SPSS 22软件对数据进行分析。结果:拉撒路多模式治疗对降低焦虑(P<0.001)、心理困扰(P<0.001)、提高工作记忆(P<0.001)有显著效果。结论:拉撒路多模式治疗对MS患者的焦虑、心理困扰和工作记忆均有较好的治疗效果,可用于减轻MS患者的心理问题。
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引用次数: 0
Human Leukocyte Antigen as a Predictor of COVID-19 Severity 人白细胞抗原作为COVID-19严重程度的预测因子
Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.27
A. Jandaghi, Afshin Samiei, Narges Khaghanzadeh
Since the spread of the coronavirus disease 2019 (COVID-19) pandemic, many countries have been suffering from the disease, and patients exhibit an extensive spectrum of symptoms from mild to severe, and in some cases, it leads to death. Identifying vulnerability factors may help detect very high-risk subjects to prevent disease mortality. Since people have different human leukocyte antigen (HLA) alleles, and the frequency of the alleles varies between different races and geographic regions, it is inferred that there is an association between HLA and the vulnerability of the population. The present study aimed to find the most frequent HLA alleles that profoundly affect COVID-19 outcomes. To find the relevant articles, medical databases (Medline, PubMed, EMBASE, Cochrane Library, and the like) were searched by the keywords, and the results related to the association between HLA and COVID-19 morbidity were selected and briefly presented. Regarding the extracted information from several studies, HLA alleles with a strong affinity to COVID-19 epitopes such as HLA-A*11:01, HLA-A*02:06, and HLA-B*54:01 could result in mild symptoms, while those with weak affinity such as HLA-B*44:06 and HLA-B*46:01 contributed to severe symptoms and high mortality rate. Further, heterozygosity and frequency of HLA alleles could affect the disease outcome within populations. As a result, the vulnerability of the patients can be predicted through their HLA pattern, and preventive measures can be taken instantly for populations expressing high-risk alleles. HLA can be assumed as a global predictor of COVID-19 disease outcomes. High frequent alleles which affect the outcome of the disease are introduced as susceptibility-determining alleles.
自2019年冠状病毒病(COVID-19)大流行传播以来,许多国家都遭受了这种疾病的困扰,患者表现出从轻微到严重的广泛症状,在某些情况下还会导致死亡。确定易感因素可能有助于发现高危人群,以预防疾病死亡。由于人类白细胞抗原(HLA)等位基因不同,且等位基因的频率在不同种族和地理区域之间存在差异,因此可以推断HLA与人群易感性之间存在关联。本研究旨在找到影响COVID-19预后的最常见HLA等位基因。通过关键词检索医学数据库(Medline、PubMed、EMBASE、Cochrane Library等)查找相关文献,选取HLA与COVID-19发病相关的结果并简要介绍。从多项研究提取的信息来看,HLA- a *11:01、HLA- a *02:06、HLA- b *54:01等与COVID-19表位亲和力较强的HLA等位基因可导致症状较轻,HLA- b *44:06、HLA- b *46:01等亲和力较弱的HLA等位基因可导致症状较重、死亡率较高。此外,HLA等位基因的杂合性和频率可能影响人群内的疾病结果。因此,可以通过HLA型预测患者的易感性,对表达高危等位基因的人群及时采取预防措施。HLA可以被认为是COVID-19疾病结局的全球预测因子。影响疾病结果的高频率等位基因被引入作为决定易感性的等位基因。
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引用次数: 0
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Hormozgan Medical Journal
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