Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.687
S. Ham, Bishoy Botros, J. Mejía, K. Fertitta, C. Mejia, E. Gurzenda, Xinhua Lin, N. Hanna
{"title":"Biomarkers From Minimally Invasive Sampling That Reflects The Placental Immune Environment","authors":"S. Ham, Bishoy Botros, J. Mejía, K. Fertitta, C. Mejia, E. Gurzenda, Xinhua Lin, N. Hanna","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.687","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.687","url":null,"abstract":"","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116273827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.749
S. Joshi, Vilmaris Quiñones Cardona, Ogechukwu R. Menkiti
Background: Persistent pulmonary hypertension of newborn (PPHN) affects 1.9 per 1000 live births and has a varied mortality ranging between 4-33%. Although inhaled nitric oxide (iNO) has reduced the need for Extracorporeal membrane oxygenation (ECMO) in this population, refractory cases persist. Vasopressin is gaining favor as a treatment modality in neonates despite limited data and concerns for hyponatremia and decreased intestinal perfusion. Objective: To describe the effect of vasopressin on oxygenation and systemic blood …
{"title":"Utility of Vasopressin Rescue Therapy in Neonates with Persistent Pulmonary Hypertension of the Newborn","authors":"S. Joshi, Vilmaris Quiñones Cardona, Ogechukwu R. Menkiti","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.749","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.749","url":null,"abstract":"Background: Persistent pulmonary hypertension of newborn (PPHN) affects 1.9 per 1000 live births and has a varied mortality ranging between 4-33%. Although inhaled nitric oxide (iNO) has reduced the need for Extracorporeal membrane oxygenation (ECMO) in this population, refractory cases persist. Vasopressin is gaining favor as a treatment modality in neonates despite limited data and concerns for hyponatremia and decreased intestinal perfusion. Objective: To describe the effect of vasopressin on oxygenation and systemic blood …","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115952345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.756
Keith P. Shopa, C. Wendler, S. Rivkees
Purpose: Up to 30% of low birth weight preterm infants manifest some form of periventricular white matter injury (PWMI) making it the most common form of brain injury affecting premature infants. It is believed that loss of oligodendrocyte progenitor cells (OPCs), which are proliferative cells that develop into myelinating OLs, plays a major role in PWMI causation. Presently, few pharmacological approaches specifically target OPCs resulting in increased proliferation of these cells and increased brain myelination. We discovered that diazoxide (DZ), an activator of ATP-sensitive potassium channels (KATP), promotes OPC proliferation and attenuated hypoxia induced brain injury in neonatal mice. Out of 610 Diazoxide derivatives, compound …
{"title":"Identification of Diazoxide Analogues that Stimulate Oligodendrocyte Proliferation","authors":"Keith P. Shopa, C. Wendler, S. Rivkees","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.756","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.756","url":null,"abstract":"Purpose: Up to 30% of low birth weight preterm infants manifest some form of periventricular white matter injury (PWMI) making it the most common form of brain injury affecting premature infants. It is believed that loss of oligodendrocyte progenitor cells (OPCs), which are proliferative cells that develop into myelinating OLs, plays a major role in PWMI causation. Presently, few pharmacological approaches specifically target OPCs resulting in increased proliferation of these cells and increased brain myelination. We discovered that diazoxide (DZ), an activator of ATP-sensitive potassium channels (KATP), promotes OPC proliferation and attenuated hypoxia induced brain injury in neonatal mice. Out of 610 Diazoxide derivatives, compound …","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128056213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.714
Adnan M. Ismail, Yona Nicolau, C. Uy, Fayez Bany-Mohammed, M. Aslam
{"title":"Maternal antenatal marijuana use lowers the biologic potential of umbilical cord mesenchymal stem cells","authors":"Adnan M. Ismail, Yona Nicolau, C. Uy, Fayez Bany-Mohammed, M. Aslam","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.714","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.714","url":null,"abstract":"","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127167809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.717
Anne A. Kimball, K. Miele, V. Bowen, Elizabeth A Torrone, K. Kreisel
{"title":"National and Regional Congenital Syphilis Prevention Opportunities — United States, 2018","authors":"Anne A. Kimball, K. Miele, V. Bowen, Elizabeth A Torrone, K. Kreisel","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.717","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.717","url":null,"abstract":"","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127364491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.691
C. Armstrong, Yvonne Yui, Victoria Nakibuuka-Kirabira, Patrick Bainghana, R. Kyambadde, K. Onwona-Agyeman, M. Owen, Y. Vaucher, B. Short, Leah Greenspan Hodor
{"title":"Designated Neonatal Resuscitation and Transport Team Implementation Improves Neonatal Outcomes in Low Resource Settings","authors":"C. Armstrong, Yvonne Yui, Victoria Nakibuuka-Kirabira, Patrick Bainghana, R. Kyambadde, K. Onwona-Agyeman, M. Owen, Y. Vaucher, B. Short, Leah Greenspan Hodor","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.691","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.691","url":null,"abstract":"","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121512164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.721
E. Cabacungan, S. Adams, Andrew B. Foy, Susan L. Cohen
{"title":"Post Hemorrhagic Hydrocephalus Management Among NICUs and Associated Comorbidities and Complications","authors":"E. Cabacungan, S. Adams, Andrew B. Foy, Susan L. Cohen","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.721","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.721","url":null,"abstract":"","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115108952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-24DOI: 10.1542/PEDS.147.3_MEETINGABSTRACT.737
P. Rees, B. Carter, C. Gale, S. Petrou, B. Botting, A. Sutcliffe
{"title":"The Cost of Neonatal Abstinence Syndrome To The National Health Service: An Economic Analysis Of A National Database","authors":"P. Rees, B. Carter, C. Gale, S. Petrou, B. Botting, A. Sutcliffe","doi":"10.1542/PEDS.147.3_MEETINGABSTRACT.737","DOIUrl":"https://doi.org/10.1542/PEDS.147.3_MEETINGABSTRACT.737","url":null,"abstract":"","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129866403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie Chew, A. Ehrlich, Johann Prambs, B. Henrick
Bacterial metabolites, including short chain fatty acids (SCFA) are essential for host cells to maintain homeostasis. Previous findings showed exclusively breastfed infants colonized with B. infantis EVC001 have significantly increased fecal organic acid concentrations, specifically lactate and acetate as compared to infants not colonized with B. infantis, we investigated the effect of fecal water (FW) from two distinct populations on enterocyte proliferation and morphology in vitro. FW were derived from fecal samples from infants colonized with B. infantis EVC001 (EVC001) and infants not colonized with B. infantis (controls) were added to adult and premature enterocyte cell lines to assess growth, proliferation and cytotoxicity. Microscopic images were taken to observe morphological differences. Intestinal epithelial cells (IECs; Caco-2 and HIEC-6 cells) exposed to EVC001 FW showed significantly increased proliferation shown by ATP expression compared to medium alone and control FW (P < 0.0001). Conversely, significantly decreased lactate dehydrogenase, an indication of decreased membrane integrity, was detected in enterocytes exposed to EVC001 FW compared to controls FW (P < 0.01). Specific bacterial metabolites, lactate and acetate at median physiological concentrations found in EVC001 infant FW significantly increased Caco-2 intestinal integrity measured by transepithelial electrical resistance compared to medium alone (P < 0.01, P < 0.05, respectively), while control levels did not significantly increase proliferation. Furthermore, control FW altered the morphology of enterocytes compared to cells exposed to EVC001 FW or medium alone. EVC001 FW and specific bacterial metabolites, lactate and acetate significantly increased enterocyte proliferation compared to control FW and medium alone, while control FW negatively affected cell growth, membrane integrity and cell morphology; suggesting metabolites produced by B. infantis EVC001 promote enterocyte growth and improve intestinal integrity in both adult and premature infants. Evolve Biosystems.
{"title":"B. infantis EVC001 Metabolites Improve Enterocyte Proliferation In Vitro","authors":"Stephanie Chew, A. Ehrlich, Johann Prambs, B. Henrick","doi":"10.1093/cdn/nzaa054_032","DOIUrl":"https://doi.org/10.1093/cdn/nzaa054_032","url":null,"abstract":"\u0000 \u0000 \u0000 Bacterial metabolites, including short chain fatty acids (SCFA) are essential for host cells to maintain homeostasis. Previous findings showed exclusively breastfed infants colonized with B. infantis EVC001 have significantly increased fecal organic acid concentrations, specifically lactate and acetate as compared to infants not colonized with B. infantis, we investigated the effect of fecal water (FW) from two distinct populations on enterocyte proliferation and morphology in vitro.\u0000 \u0000 \u0000 \u0000 FW were derived from fecal samples from infants colonized with B. infantis EVC001 (EVC001) and infants not colonized with B. infantis (controls) were added to adult and premature enterocyte cell lines to assess growth, proliferation and cytotoxicity. Microscopic images were taken to observe morphological differences.\u0000 \u0000 \u0000 \u0000 Intestinal epithelial cells (IECs; Caco-2 and HIEC-6 cells) exposed to EVC001 FW showed significantly increased proliferation shown by ATP expression compared to medium alone and control FW (P < 0.0001). Conversely, significantly decreased lactate dehydrogenase, an indication of decreased membrane integrity, was detected in enterocytes exposed to EVC001 FW compared to controls FW (P < 0.01). Specific bacterial metabolites, lactate and acetate at median physiological concentrations found in EVC001 infant FW significantly increased Caco-2 intestinal integrity measured by transepithelial electrical resistance compared to medium alone (P < 0.01, P < 0.05, respectively), while control levels did not significantly increase proliferation. Furthermore, control FW altered the morphology of enterocytes compared to cells exposed to EVC001 FW or medium alone.\u0000 \u0000 \u0000 \u0000 EVC001 FW and specific bacterial metabolites, lactate and acetate significantly increased enterocyte proliferation compared to control FW and medium alone, while control FW negatively affected cell growth, membrane integrity and cell morphology; suggesting metabolites produced by B. infantis EVC001 promote enterocyte growth and improve intestinal integrity in both adult and premature infants.\u0000 \u0000 \u0000 \u0000 Evolve Biosystems.\u0000","PeriodicalId":275302,"journal":{"name":"Section on Neonatal-Perinatal Medicine Program","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127538383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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