Eco-Environment & Health最新文献_第7页

Long-term exposure to low-level ambient BTEX and site-specific cancer risk: A national cohort study in the UK Biobank 长期暴露于低水平环境BTEX和特定部位的癌症风险：英国生物银行的一项国家队列研究

Eco-Environment & Health

Pub Date : 2025-04-09 DOI: 10.1016/j.eehl.2025.100146

Kexin Yu , Ying Xiong , Renjie Chen , Jing Cai , Yaoxian Huang , Haidong Kan

Benzene, toluene, ethylbenzene, and xylene (BTEX) have been associated with certain cancers in the occupational population. This study aimed to investigate the associations between low-level ambient BTEX exposure and cancer risks in the general population. We leveraged data from the UK Biobank and included individuals free of cancer at 2006–2010 baseline. Annual concentrations of BTEX were estimated using a chemistry-climate model, and the associations between BTEX and incident overall and 18 site-specific cancers were investigated with Cox proportional hazard models. We also fitted restricted cubic splines to explore the exposure-response relationships. The study sample comprised 409,579 participants [mean age 56.2 (8.11) years; 219,315 (53.5%) females]. Over a mean (SD) follow-up period of 11.2 (2.64) years (4,597,164 person-years), 60,777 overall incident cancer cases occurred. The results showed significant associations between overall cancers and benzene [HR 1.93 (95% CI: 1.89, 1.96)], toluene [1.25 (1.23, 1.26)] and xylene [1.11 (1.10, 1.12)]. Benzene and toluene were associated with a higher risk of 18 site-specific cancers. For xylenes (a summation of ethylbenzene, m/p-xylene, and o-xylene in the model), significant associations with multiple myeloma, hepatobiliary tract, thyroid, or connective soft tissue were not observed. Exposure-response curves suggested a higher risk of overall cancer beyond the benzene threshold. For toluene and xylene, there was no threshold or plateau across the range of exposures. This large-scale prospective cohort study demonstrates that long-term exposure to low-level ambient BTEX could increase the risk of overall and site-specific cancers in the general population.

苯、甲苯、乙苯和二甲苯（BTEX）与职业人群中的某些癌症有关。本研究旨在调查普通人群中低水平环境BTEX暴露与癌症风险之间的关系。我们利用了英国生物银行的数据，并纳入了2006-2010年基线无癌症的个体。使用化学-气候模型估计BTEX的年浓度，并使用Cox比例风险模型调查BTEX与总体事件和18种部位特异性癌症之间的关系。我们还拟合了限制三次样条曲线来探索暴露-响应关系。研究样本包括409,579名参与者[平均年龄56.2（8.11）岁；219,315（53.5%）女性]。在平均（SD） 11.2（2.64）年（4,597,164人年）的随访期间，总共发生了60,777例癌症病例。结果显示，总体癌症与苯[相对危险度1.93(95%可信区间：1.89,1.96)]、甲苯[1.25(1.23,1.26)]和二甲苯[1.11(1.10,1.12)]之间存在显著关联。苯和甲苯与18种特定部位癌症的高风险相关。对于二甲苯（模型中乙苯、间/对二甲苯和邻二甲苯的总和），未观察到与多发性骨髓瘤、肝胆道、甲状腺或结缔组织软组织的显著关联。暴露-反应曲线表明，超过苯阈值，总体癌症风险更高。对于甲苯和二甲苯，在整个暴露范围内没有阈值或平台。这项大规模前瞻性队列研究表明，长期暴露于低水平的环境BTEX可能会增加普通人群患整体和部位特异性癌症的风险。

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引用次数: 0

Can oxidative potential be a plant risk indicator for heavy metals contaminated soil? Analysis of ryegrass (Lolium perenne L.) metabolome based on machine learning 氧化电位可以作为重金属污染土壤的植物风险指标吗？基于机器学习的黑麦草代谢组分析

Eco-Environment & Health

Pub Date : 2025-03-03 DOI: 10.1016/j.eehl.2025.100140

Chunmei Ran , Meiqi Guo , Yuan Wang , Ye Li , Jiao Wang , Yinqing Zhang , Chunguang Liu , Bridget A. Bergquist , Chu Peng

Evaluating the plant risk of soil pollution by plant physiological indices usually requires a long cycle and has significant uncertainty. In this study, oxidative potential (OP) of the in situ heavy metal contaminated soils was measured by the dithiothreitol method. The oxidative stress response of the model plant ryegrass (Lolium perenne L.) induced by heavy metal contaminated soil was evaluated by the biomarkers, including superoxide dismutase and total antioxidant capacity. The comprehensive biomarker response index has a significant exponential correlation with the OP of soil (r = 0.923, p < 0.01) in ryegrass. Metabolomics analysis also showed a significant relationship of the metabolic effect level index of amino acids and sugars with OP. Random forest was selected from four machine learning models to screen the metabolites most relevant to OP, and Shapley additive explanations analysis was used to explain the contribution and the influence direction of the features on the model. Based on the selected 20 metabolites, the metabolic pathways most related to OP in plants, including alkaloid synthesis and amino acids metabolism, were identified. Compared to the plant physiological indices, OP is a more stable and faster indicator for the plant risk assessment of heavy metals contaminated soil.

利用植物生理指标评估土壤污染的植物风险通常需要较长的周期，且具有较大的不确定性。采用二硫代苏糖醇法测定了原位重金属污染土壤的氧化电位。采用超氧化物歧化酶和总抗氧化能力等生物标志物评价了模式植物黑麦草（Lolium perenne L.）在重金属污染土壤下的氧化应激反应。综合生物标志物响应指数与土壤有机肥呈显著指数相关(r = 0.923, p <；0.01)。代谢组学分析也显示氨基酸和糖的代谢效应水平指数与OP之间存在显著关系。我们从四个机器学习模型中选择随机森林筛选与OP最相关的代谢物，并使用Shapley加性解释分析来解释特征对模型的贡献和影响方向。根据选取的20种代谢物，确定了植物中与OP最相关的代谢途径，包括生物碱合成和氨基酸代谢。相对于植物生理指标，OP是重金属污染土壤植物风险评价的更稳定、更快的指标。

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引用次数: 0

Targeted conversion of waste PET into dimethyl terephthalate and ethylene carbonate under metal-free conditions 废PET在无金属条件下定向转化为对苯二甲酸二甲酯和碳酸乙烯

Eco-Environment & Health

Pub Date : 2025-02-24 DOI: 10.1016/j.eehl.2025.100139

Minghao Zhang , Yijin Lu , Zhuo Wang , Xiong Gao , Xuanhang Luo , Xin Shen , Weixiang Wu , Qingqing Mei

Ionic liquid-catalyzed methanolysis emerges as an efficient technique for transforming PET into premium-grade dimethyl terephthalate (DMT). However, incomplete depolymerization remains a major obstacle to the further industrial application of IL-catalyzed PET methanolysis. The proposed method utilized dimethyl carbonate (DMC) as the solvent for the complete methanolysis of waste PET under mild conditions, resulting in pure DMT and ethylene carbonate (EC) within 2.5 h. The use of 1-ethyl-3-methylimidazolium acetate ([EMIm][OAc]) as the IL catalyst significantly enhanced the reaction efficiency. Spectroscopic analyses using ¹H NMR and FT-IR confirmed the pivotal role of [EMIm][OAc] in establishing multiple hydrogen bonds with the reactants (PET, DMC, and MeOH) and the intermediate [ethylene glycol (EG)] during the catalytic process. This catalytic system exhibited remarkable performance, achieving complete conversion of PET, which resulted in the production of DMT and EC with yields of 99% and 91%, respectively. Moreover, this versatile approach is applicable to the upcycling of a wide variety of commercial polyesters and polycarbonates, underscoring its potential as a comprehensive solution for plastic waste management.

离子液体催化甲醇分解是将PET转化为优质对苯二甲酸二甲酯（DMT）的一种有效技术。然而，不完全解聚仍然是阻碍il催化PET甲醇分解进一步工业应用的主要障碍。该方法以碳酸二甲酯（DMC）为溶剂，在温和条件下对废PET进行完全甲醇分解，在2.5 h内得到纯DMT和碳酸乙烯酯（EC）。采用1-乙基-3-甲基咪唑醋酸酯（[EMIm][OAc]）作为IL催化剂，显著提高了反应效率。利用1H NMR和FT-IR进行的光谱分析证实了[EMIm][OAc]在催化过程中与反应物（PET， DMC和MeOH）和中间体[乙二醇（EG）]建立多个氢键的关键作用。该催化体系表现出优异的性能，实现了PET的完全转化，得到了DMT和EC，产率分别为99%和91%。此外，这种通用方法适用于各种商业聚酯和聚碳酸酯的升级回收，强调了其作为塑料废物管理综合解决方案的潜力。

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引用次数: 0

Corrigendum to “A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health” [Eco-Environ. Health (2023)195–207] “接触微和纳米塑料对人体组织积累和健康影响的系统审查”[生态环境]的勘误表。卫生(2023)195 - 207年)

Eco-Environment & Health

Pub Date : 2025-02-18 DOI: 10.1016/j.eehl.2025.100137

Yudong Feng , Chen Tu , Ruijie Li , Di Wu , Jie Yang , Yankai Xia , Willie J.G.M. Peijnenburg , Yongming Luo

引用次数: 0

The wheel of time: The environmental dance of aged micro- and nanoplastics and their biological resonance 时间之轮：老化微纳米塑料的环境之舞及其生物共振

Eco-Environment & Health

Pub Date : 2025-02-14 DOI: 10.1016/j.eehl.2025.100138

Hongjian Li , Lihua Bai , Sijia Liang , Xiru Chen , Xinyue Gu , Chao Wang , Cheng Gu

The aging of micro- and nanoplastics (MNPs) significantly affects their environmental behavior and ecological impacts in both aquatic and terrestrial ecosystems. This review explored the known effects of aging on MNPs and identified several key perspectives. Firstly, aging can alter the environmental fate and transport of MNPs due to changes in their surface properties. This alteration accelerates their accumulation in specific habitats like oceans and soils, resulting in increased bioaccumulation by organisms. In addition, aged MNPs interact differently with living organisms than their pristine counterparts by influencing the attachment of biofilms and other microorganisms in aquatic ecosystems. Moreover, the aging processes of MNPs exhibit adverse effects on aquatic and terrestrial organisms via increasing the bioavailability and potential toxicity of MNPs as degradation products are released. Last but not least, the biodegradation potential of MNPs can be altered by the aging process, thus affecting their degradation rates and pathways in the environment. However, there are still knowledge gaps regarding the natural aging behaviors of MNPs, such as the aging mechanisms of different types of plastic, the influence of environmental factors, the release of pollutants, and even the effects of aging on their transformation in different ecosystems. Therefore, a great contribution can be made to sustainable plastic use and environmental preservation by studying the natural aging of common MNPs and their subsequent biological effects.

微纳米塑料（MNPs）的老化显著影响其在水生和陆地生态系统中的环境行为和生态影响。本综述探讨了衰老对MNPs的已知影响，并确定了几个关键观点。首先，老化可以改变MNPs的环境命运和运输，这是由于其表面性质的变化。这种变化加速了它们在海洋和土壤等特定栖息地的积累，导致生物体的生物积累增加。此外，衰老的MNPs通过影响水生生态系统中生物膜和其他微生物的附着，与原始的MNPs不同地与生物体相互作用。此外，MNPs的老化过程通过增加MNPs降解产物的生物利用度和潜在毒性，对水生和陆生生物产生不利影响。最后但并非最不重要的是，MNPs的生物降解潜力会随着老化过程而改变，从而影响其在环境中的降解速率和途径。然而，对于MNPs的自然老化行为，如不同类型塑料的老化机制，环境因素的影响，污染物的释放，甚至老化对其在不同生态系统中的转化的影响，仍然存在知识空白。因此，研究常见MNPs的自然老化及其后续的生物效应，可以为塑料的可持续利用和环境保护做出很大贡献。

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引用次数: 0

Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer 微塑料通过丰富宿主细菌和促进基因水平转移，增强了海水养殖沉积物中抗生素抗性基因的流行

Eco-Environment & Health

Pub Date : 2025-01-30 DOI: 10.1016/j.eehl.2025.100136

Yifan Liu , Liuqingqing Liu , Xiao Wang , Mengying Shao , Zihan Wei , Lina Wang , Bing Li , Chenguang Li , Xianxiang Luo , Fengmin Li , Hao Zheng

Microplastics (MPs) and antibiotic resistance genes (ARGs) pose significant challenges to the One Health framework due to their intricate and multifaceted ecological and environmental impacts. However, the understanding of how MP properties influence ARG prevalence in mariculture sediments remains limited. Herein, the polystyrene (PS) and polyvinyl chloride (PVC) MPs with different sizes (20–120 μm and 0.5–2.0 mm) were selected to evaluate their impacts and underlying mechanisms driving ARGs dissemination. The results showed that PS and PVC MPs increased the relative abundance of ARGs by 1.41–2.50-fold and 2.01–2.84-fold, respectively, compared with control, particularly high-risk genes. The polymer type effect was identified as more influential than the size effect in driving the sediment resistome evolution. PVC shifted the microbial community assembly from stochastic to deterministic processes, thus enriching ARG host pathogens. Furthermore, the highly hydrophobic PS not only recruited the host bacteria colonization but also facilitated ARG exchange within the plastisphere. The exogenous additives released by PVC (e.g., heavy metals, bisphenol A, and tridecyl ester) and the particles synergistically promoted ARG conjugative transfer by inducing oxidative stress and enhancing cell membrane permeability. These findings revealed how MPs characteristics facilitated the spread of ARGs in marine benthic ecosystems, underscoring the importance of mitigating MPs pollution to maintain mariculture ecosystem health, prevent zoonotic diseases, and balance global mariculture with ecological health.

微塑料（MPs）和抗生素耐药基因（ARGs）由于其复杂和多方面的生态和环境影响，对“同一个健康”框架构成了重大挑战。然而，MP特性如何影响海水养殖沉积物中ARG流行的理解仍然有限。本文选择不同尺寸（20 ~ 120 μm和0.5 ~ 2.0 mm）的聚苯乙烯（PS）和聚氯乙烯（PVC） MPs，研究了它们对ARGs扩散的影响和潜在机制。结果表明，PS和PVC MPs与对照相比，ARGs的相对丰度分别提高了1.41 ~ 2.50倍和2.01 ~ 2.84倍，特别是与高危基因相比。聚合物类型效应比粒径效应对沉积物抵抗体演化的影响更大。PVC将微生物群落组装从随机过程转变为确定性过程，从而丰富了ARG宿主病原体。此外，高疏水性PS不仅招募了宿主细菌的定植，而且促进了塑料圈内ARG的交换。PVC释放的外源添加剂（重金属、双酚A、三烷基酯等）和颗粒通过诱导氧化应激、增强细胞膜通透性等方式协同促进ARG共轭转移。这些发现揭示了MPs的特征如何促进ARGs在海洋底栖生态系统中的传播，强调了减轻MPs污染对维持海水养殖生态系统健康、预防人畜共患疾病以及平衡全球海水养殖与生态健康的重要性。

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引用次数: 0

Effects of nanoscale zero-valent iron loaded biochar on the fate of phenanthrene in soil-radish (Raphanus sativus L. var.radculus pers) system 纳米级零价铁负载生物炭对土壤-萝卜系统中菲命运的影响

Eco-Environment & Health

Pub Date : 2025-01-22 DOI: 10.1016/j.eehl.2025.100134

Lianzhou Shen , Yue Cai , Juan Gao

Nanoscale zero-valent iron loaded on biochar (nZVI@BC) has been proven to be effective in activating persulfate to remediate soil organic pollutants. However, studies on subsequent plant growth and microbial community changes in remediated soil remain limited. In this study, nZVI@BC, nZVI, and nanoscale biochar (nBC) were ball-mill produced and applied as amendments in pot experiments with PAH-contaminated soil to investigate their impacts on soil-crop (radish, Raphanus sativus L.) systems, and the widely distributed phenanthrene (Phe) was selected as model pollutant. The results indicate that nZVI@BC could induce more (75%) Phe accumulation in radish compared to the control treatment, but did not result in significant differences in plant biomass or enzyme activity. In Phe non-contaminated treatments, the Fe content of radish shoots increased from 86.87 ± 5.61 mg/kg DW without material application to 125.20 ± 11.93 mg/kg DW with nZVI@BC, while no significant differences were observed in roots. nZVI@BC and nBC increased the non-desorbed fraction of PAHs with low bio-availability by 13.6% and 10.2%, respectively, after 45 days compared to the control treatment. Illumina MiSeq sequencing revealed that nZVI@BC did not adversely affect the richness and diversity of soil microbial communities. Instead, it promoted the enrichment of bacteria related to the degradation of organic pollutants, such as Lysobacter and Spingomonas. The findings suggest that nZVI@BC after chemical oxidation remediation might be harmful to subsequent plants and ecosystems but much better than nZVI alone. The amount of nZVI@BC should be accurately calculated before chemical oxidation remediation.

纳米级零价铁负载在生物炭（nZVI@BC）已被证明是有效的激活过硫酸盐修复土壤有机污染物。然而，对修复后土壤中植物生长和微生物群落变化的研究仍然有限。本研究以球磨法制备nZVI@BC、nZVI和纳米尺度生物炭（nBC）作为改进剂，在多环芳烃污染的土壤中进行盆栽试验，研究其对土壤-作物（萝卜、萝卜）系统的影响，并选择广泛分布的菲（Phe）作为模型污染物。结果表明，与对照处理相比，nZVI@BC处理可诱导萝卜体内更多（75%）的Phe积累，但对植株生物量和酶活性没有显著影响。在苯丙酸未污染处理下，萝卜茎部铁含量由未施料的86.87±5.61 mg/kg DW增加至nZVI@BC处理下的125.20±11.93 mg/kg DW，根系铁含量差异不显著。与对照处理相比，nZVI@BC和nBC处理45天后，低生物利用度PAHs的未解吸部分分别增加了13.6%和10.2%。Illumina MiSeq测序结果显示nZVI@BC对土壤微生物群落的丰富度和多样性没有不利影响。相反，它促进了与有机污染物降解有关的细菌的富集，如溶杆菌和自旋单胞菌。研究结果表明，nZVI@BC经过化学氧化修复后可能对后续植物和生态系统有害，但比单独使用nZVI要好得多。化学氧化修复前应准确计算nZVI@BC的用量。

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引用次数: 0

Diagnostic performance of allele-specific RT-qPCR and genomic sequencing in wastewater-based surveillance of SARS-CoV-2 等位基因特异性RT-qPCR和基因组测序在基于废水的SARS-CoV-2监测中的诊断价值

Eco-Environment & Health

Pub Date : 2025-01-21 DOI: 10.1016/j.eehl.2025.100135

Md Pervez Kabir , Élisabeth Mercier , Walaa Eid , Julio Plaza-Diaz , Patrick M. D'Aoust , Chrystal Landgraff , Lawrence Goodridge , Opeyemi U. Lawal , Shen Wan , Nada Hegazy , Tram Nguyen , Chandler Wong , Ocean Thakali , Lakshmi Pisharody , Sean Stephenson , Tyson E. Graber , Robert Delatolla

Clinical genomic surveillance is regarded as the gold standard for monitoring SARS-CoV-2 variants globally. However, as the pandemic wanes, reduced testing poses a risk to effectively tracking the trajectory of these variants within populations. Wastewater-based genomic surveillance that estimates variant frequency based on its defining set of alleles derived from clinical genomic surveillance has been successfully implemented. This method has its challenges, and allele-specific (AS) RT-qPCR or RT-dPCR may instead be used as a complementary method for estimating variant prevalence. Demonstrating equivalent performance of these methods is a prerequisite for their continued application in current and future pandemics. Here, we compared single-allele frequency using AS-RT-qPCR, to single-allele or haplotype frequency estimations derived from amplicon-based sequencing to estimate variant prevalence in wastewater during emergent and prevalent periods of Delta, Omicron, and two sub-lineages of Omicron. We found that all three methods of frequency estimation were concordant and contained sufficient information to describe the trajectory of variant prevalence. We further confirmed the accuracy of these methods by quantifying the diagnostic performance through Youden's index. The Youden's index of AS-RT-qPCR was reduced during the low prevalence period of a particular variant while the same allele in sequencing was negatively influenced due to insufficient read depth. Youden's index of haplotype-based calls was negatively influenced when alleles were common between variants. Coupling AS-RT-qPCR with sequencing can overcome the shortcomings of either platform and provide a comprehensive picture to the stakeholders for public health responses.

临床基因组监测被认为是全球监测SARS-CoV-2变异的金标准。然而，随着大流行的减弱，检测的减少对有效追踪人群中这些变异的轨迹构成了风险。基于废水的基因组监测已经成功实施，该监测基于临床基因组监测得出的等位基因的定义集来估计变异频率。这种方法有其挑战，等位基因特异性（AS） RT-qPCR或RT-dPCR可以作为估计变异流行率的补充方法。证明这些方法的同等性能是在当前和未来大流行病中继续应用这些方法的先决条件。在这里，我们使用AS-RT-qPCR将单等位基因频率与基于扩增子测序的单等位基因或单倍型频率进行比较，以估计Delta、Omicron和Omicron的两个亚谱系在突发性和流行期废水中的变异发生率。我们发现所有三种频率估计方法是一致的，并且包含足够的信息来描述变异流行的轨迹。我们通过约登指数对诊断性能进行量化，进一步证实了这些方法的准确性。AS-RT-qPCR的约登指数在特定变异的低流行期降低，而同一等位基因在测序中由于读取深度不足而受到负面影响。当等位基因在变体之间相同时，基于单倍型的呼叫的约登指数受到负向影响。将AS-RT-qPCR与测序相结合可以克服任一平台的缺点，并为公共卫生反应的利益攸关方提供全面的情况。

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引用次数: 0

Thiamethoxam at environmentally relevant concentrations induces neurotoxicity in zebrafish larvae through binding with multiple receptors 环境相关浓度的噻虫嗪通过与多种受体结合诱导斑马鱼幼虫神经毒性

Eco-Environment & Health

Pub Date : 2025-01-17 DOI: 10.1016/j.eehl.2024.12.002

Xiuwen Li , Hanbing Zhao , Minjuan Gong , Feng Zhang , Shengnan Liu , Zepeng Zhang , Yide He , Henner Hollert , Xiaowei Zhang , Wei Shi , Qing Zhou , Aimin Li , Peng Shi

Thiamethoxam (THM) is one of the most widely used insecticides globally, which was designed to selectively target nicotinic acetylcholine receptors (nAChRs) in the insect nervous system and is generally considered safe for non-targeted organisms. However, increasing evidence has demonstrated its neurotoxicity in aquatic organisms, though the underlying mechanisms, especially at environmentally relevant concentrations, remain largely unclear. In this study, the swimming distance of zebrafish was significantly shortened by 14.06%–21.64% after exposure to THM at 10–1000 ng/L. This behavioral impairment may result from the damage to nervous and visual systems, as confirmed by notable apoptosis, histological analysis of the eyes, and differential expression of numerous genes. Molecular docking and biomarkers assays found that THM can bind with nAChR and multiple hormone receptors, with binding energies varying from −3.75 to −6.74 kcal/mol. Consequently, the concentrations of a neurotransmitter (acetylcholine) and related hormones (cortisol, triiodothyronine, thyroxine, and thyroid-stimulating hormone) were significantly affected. Further investigations using a weighted gene correlation network and metabolomics suggest that THM may enter the cell via endocytosis and bind with multiple hormone receptors, potentially activating the MAPK signaling pathway. This activation may disrupt purine and pyrimidine metabolism in the cell nucleus, ultimately leading to cell apoptosis and neurotoxicity. This study reveals that THM, even at environmentally relevant concentrations, poses neurological risks to zebrafish and underscore the need for urgent attention to the ecological impacts of THM in aquatic environments.

噻虫嗪（Thiamethoxam， THM）是全球使用最广泛的杀虫剂之一，它被设计用于选择性靶向昆虫神经系统中的烟碱乙酰胆碱受体（nAChRs），通常被认为对非靶向生物是安全的。然而，越来越多的证据表明其对水生生物具有神经毒性，尽管其潜在机制，特别是在与环境有关的浓度下，仍不清楚。在本研究中，暴露于10-1000 ng/L的THM后，斑马鱼的游泳距离显著缩短14.06%-21.64%。这种行为障碍可能是由神经和视觉系统的损伤引起的，正如显著的细胞凋亡、眼睛的组织学分析和许多基因的差异表达所证实的那样。分子对接和生物标志物分析发现，THM可以与nAChR和多种激素受体结合，结合能在−3.75 ~−6.74 kcal/mol之间变化。因此，神经递质（乙酰胆碱）和相关激素（皮质醇、三碘甲状腺原氨酸、甲状腺素和促甲状腺激素）的浓度受到显著影响。利用加权基因相关网络和代谢组学的进一步研究表明，THM可能通过内吞作用进入细胞，并与多种激素受体结合，潜在地激活MAPK信号通路。这种激活可能会破坏细胞核中的嘌呤和嘧啶代谢，最终导致细胞凋亡和神经毒性。本研究表明，即使在与环境相关的浓度下，THM也会对斑马鱼造成神经系统风险，并强调迫切需要关注THM在水生环境中的生态影响。

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引用次数: 0

Children-specific environmental protection strategies are needed in China 中国需要针对儿童的环境保护战略

Eco-Environment & Health

Pub Date : 2025-01-09 DOI: 10.1016/j.eehl.2025.01.001

Jun Zhang , Wen Jiang , Fangbiao Tao , Guodong Ding , Fei Li , Ying Tian , Shu Tao

China, home to over 250 million children, has witnessed remarkable economic development in recent decades, successfully addressing many issues related to basic hygiene and sanitation in children, thereby altering the childhood disease spectrum. However, the emergence of environment-related disorders among children has become a significant concern. Despite the rapid accumulation of scientific knowledge on the adverse effects of environmental pollution on child health, the availability of children-specific protective strategies and actions remains alarmingly low. This commentary synthesizes the information and viewpoints presented and discussed by experts at the International Forum on Children's Environmental Health in China. It summarizes the strategies and actions proposed to reduce adverse environmental exposure and protect children's short- and long-term health and a call for more children-centered evidence-action transformation. The following four specific actions were proposed: (1) strengthen health education in parents, caregivers, and children, and personal protection for children; (2) monitor child exposure and environment-related health status; (3) set up child-specific interventions and regulations; and (4) conduct more research on environment exposures and child health.

近几十年来，拥有2.5亿多儿童的中国取得了举世瞩目的经济发展，成功解决了许多与儿童基本卫生和环境卫生有关的问题，从而改变了儿童疾病谱。然而，儿童中出现的与环境有关的疾病已成为一个值得关注的问题。尽管关于环境污染对儿童健康的不利影响的科学知识迅速积累，但针对儿童的保护战略和行动仍然少得惊人。本评论综合了专家们在中国儿童环境健康国际论坛上提出和讨论的信息和观点。总结了为减少不良环境暴露和保护儿童短期和长期健康而提出的战略和行动，并呼吁开展更多以儿童为中心的证据-行动转变。建议采取以下四项具体行动：(1)加强对家长、照顾者和儿童的健康教育，加强对儿童的个人保护；(2)监测儿童接触环境和与环境有关的健康状况；(3)建立针对儿童的干预措施和规章制度；(4)开展更多环境暴露与儿童健康的研究。

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