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Neural Correlates of Self-Generated Imagery and Cognition Throughout the Sleep Cycle 在整个睡眠周期中,自我产生的意象和认知的神经关联
Pub Date : 2016-10-06 DOI: 10.1093/OXFORDHB/9780190464745.013.16
K. Fox, M. Girn
Humans have been aware for thousands of years that sleep comes in many forms, accompanied by different kinds of mental content. We review the first-person report literature on the frequency and type of content experienced in various stages of sleep, showing that different sleep stages are dissociable at the subjective level. We then relate these subjective differences to the growing literature differentiating the various sleep stages at the neurophysiological level, including evidence from electrophysiology, neurochemistry, and functional neuroimaging. We suggest that there is emerging evidence for relationships between sleep stage, neurophysiological activity, and subjective experiences. Specifically, we emphasize that functional neuroimaging work suggests a parallel between activation and deactivation of default network and visual network brain areas and the varying frequency and intensity of imagery and dream mentation across sleep stages; additionally, frontoparietal control network activity across sleep stages may parallel levels of cognitive control and meta-awareness. Together these findings suggest intriguing brain-mind isomorphisms and may serve as a first step toward a comprehensive understanding of the relationship between neurophysiology and psychology in sleep and dreaming.
几千年来,人类一直意识到睡眠有多种形式,伴随着不同类型的精神内容。我们回顾了第一人称报告中关于不同睡眠阶段所经历的内容的频率和类型的文献,表明不同的睡眠阶段在主观层面上是可分离的。然后,我们将这些主观差异与越来越多的文献联系起来,这些文献在神经生理学水平上区分了不同的睡眠阶段,包括来自电生理学、神经化学和功能神经影像学的证据。我们认为有新的证据表明睡眠阶段、神经生理活动和主观体验之间存在关系。具体来说,我们强调功能性神经成像工作表明,默认网络和视觉网络脑区域的激活和失活与睡眠阶段图像和梦的频率和强度的变化之间存在平行关系;此外,睡眠阶段的额顶叶控制网络活动可能与认知控制和元意识水平平行。综上所述,这些发现表明了有趣的脑-心同构现象,可能是全面理解睡眠和做梦中神经生理学和心理学之间关系的第一步。
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引用次数: 6
Grand Challenges for Global Brain Sciences 全球脑科学面临的重大挑战
Pub Date : 2016-08-01 DOI: 10.12688/f1000research.10025.1
J. Vogelstein, K. Amunts, A. Andreou, D. Angelaki, G. Ascoli, Cori Bargmann, R. Burns, C. Calì, Frances S. Chance, Miyoung Chun, George M. Church, H. Cline, Todd P. Coleman, Stephanie de La Rochefoucauld, W. Denk, A. Elgoyhen, R. Cummings, Alan C. Evans, K. Harris, M. Hausser, Sean L. Hill, Samuel A. Inverso, Chad Jackson, Viren Jain, R. Kass, B. Kasthuri, Gregory Kiar, Konrad Paul Kording, S. Koushika, J. Krakauer, Story C. Landis, J. Layton, Qingming Luo, Adam H. Marblestone, D. Markowitz, Justin McArthur, B. Mensh, M. Milham, P. Mitra, P. Nesković, M. Nicolelis, Richard J O'Brien, A. Oliva, Gergő Orbán, Hanchuan Peng, Alyssa Picchini-Schaffer, M. Picciotto, J. Poline, M. Poo, A. Pouget, S. Raghavachari, Jane Roskams, T. Sejnowski, Fritz Sommer, N. Spruston, Larry Swanson, A. Toga, R. J. Vogelstein, R. Yuste, A. Zador, R. Huganir, Michael Miller
The next grand challenges for society and science are in the brain sciences. A collection of 60+ scientists from around the world, together with 10+ observers from national, private, and foundations, spent two days together discussing the top challenges that we could solve as a global community in the next decade. We eventually settled on three challenges, spanning anatomy, physiology, and medicine. Addressing all three challenges requires novel computational infrastructure. The group proposed the advent of The International Brain Station (TIBS), to address these challenges, and launch brain sciences to the next level of understanding.
社会和科学的下一个重大挑战是在脑科学领域。来自世界各地的60多名科学家,以及来自国家、私人和基金会的10多名观察员,花了两天时间讨论了我们作为一个全球社区在未来十年可以解决的主要挑战。我们最终确定了三个挑战,包括解剖学、生理学和医学。解决这三个挑战需要新的计算基础设施。该小组提议建立国际大脑站(TIBS),以应对这些挑战,并将脑科学提升到一个新的认识水平。
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引用次数: 11
Neurophysiological Investigation of Context Modulation based on Musical Stimulus 基于音乐刺激的情境调节的神经生理学研究
Pub Date : 2016-07-23 DOI: 10.13140/RG.2.1.3091.3524
Siddharth Mehrotra, Anuj Shukla, Dipanjan Roy
There are numerous studies which suggest that perhaps music is truly the language of emotions. Music seems to have an almost willful, evasive quality, defying simple explanation, and indeed requires deeper neurophysiological investigations to gain a better understanding. The current study makes an attempt in that direction to explore the effect of context on music perception. To investigate the same, we measured Galvanic Skin Responses (GSR) and self-reported emotion on 18 participants while listening to different Ragas (musical stimulus) composed of different Rasa's (emotional expression) in the different context (Neutral, Pleasant, and Unpleasant). The IAPS pictures were used to induce the emotional context in participants. Our results from this study suggest that the context can modulate emotional response in music perception but only for a shorter time scale. Interestingly, here we demonstrate by combining GSR and self-reports that this effect gradually vanishes over time and shows emotional adaptation irrespective of context. The overall findings suggest that specific context effects of music perception are transitory in nature and gets saturated on a longer time scale.
有许多研究表明,也许音乐确实是情感的语言。音乐似乎有一种近乎任性、逃避的特质,无法简单解释,确实需要更深入的神经生理学研究才能获得更好的理解。本研究试图从这一角度探讨语境对音乐感知的影响。为了研究这一点,我们测量了18名参与者在不同背景下(中性、愉快和不愉快)听由不同Rasa(情绪表达)组成的不同Ragas(音乐刺激)时的皮肤电反应(GSR)和自我情绪报告。IAPS图片用于诱导被试的情绪情境。我们的研究结果表明,背景可以调节音乐感知中的情绪反应,但仅在较短的时间尺度上。有趣的是,通过结合GSR和自我报告,我们发现这种影响会随着时间的推移逐渐消失,并表现出与环境无关的情绪适应。总体研究结果表明,音乐感知的特定环境效应本质上是短暂的,并在更长的时间尺度上达到饱和。
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引用次数: 0
Visual Motion Onset Brain–Computer Interface 视觉运动开始脑机接口
Pub Date : 2016-07-10 DOI: 10.20944/PREPRINTS201609.0126.V2
Jair Pereira Junior, Caio Teixeira, Tomasz M. Rutkowski
The paper presents a study of two novel visual motion onset stimulus-based brain-computer interfaces (vmoBCI). Two settings are compared with afferent and efferent to a computer screen center motion patterns. Online vmoBCI experiments are conducted in an oddball event-related potential (ERP) paradigm allowing for "aha-responses" decoding in EEG brainwaves. A subsequent stepwise linear discriminant analysis classification (swLDA) classification accuracy comparison is discussed based on two inter-stimulus-interval (ISI) settings of 700 and 150 ms in two online vmoBCI applications with six and eight command settings. A research hypothesis of classification accuracy non-significant differences with various ISIs is confirmed based on the two settings of 700 ms and 150 ms, as well as with various numbers of ERP response averaging scenarios. The efferent in respect to display center visual motion patterns allowed for a faster interfacing and thus they are recommended as more suitable for the no-eye-movements requiring visual BCIs.
本文研究了两种基于视觉运动刺激的新型脑机接口。两种设置比较传入和传出到计算机屏幕中心的运动模式。在线vmoBCI实验在古怪事件相关电位(ERP)范式下进行,允许在脑电波中解码“ahaa -responses”。在6条和8条指令设置的vmoBCI在线应用程序中,讨论了基于700和150 ms两种刺激间隔(ISI)设置的逐步线性判别分析分类(swLDA)分类精度比较。基于700 ms和150 ms两种设置,以及不同数量的ERP反应平均场景,确认了不同ISIs的分类准确率无显著差异的研究假设。关于显示中心视觉运动模式的传出允许更快的接口,因此它们被推荐为更适合需要视觉脑机接口的无眼运动。
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引用次数: 1
Functional Neuroimaging of Psychedelic Experience: An Overview of Psychological and Neural Effects and their Relevance to Research on Creativity, Daydreaming, and Dreaming 迷幻体验的功能神经成像:心理和神经效应综述及其与创造力、白日梦和做梦研究的相关性
Pub Date : 2016-05-23 DOI: 10.1017/9781316556238.007
K. Fox, M. Girn, Cameron C. Parro, K. Christoff
Humans have employed an incredible variety of plant-derived substances over the millennia in order to alter consciousness and perception. Among the innumerable narcotics, analgesics, 'ordeal' drugs, and other psychoactive substances discovered and used in ritualistic contexts by cultures around the world, one class in particular stands out not only for its radical psychological effects, but also for the highly charged political and legal atmosphere that has surrounded it since its widespread adoption about 50 years ago: so-called psychedelic substances. We review functional neuroimaging investigations of the neural correlates of the psychedelic experience, and highlight relationships with the psychological and neural bases of creativity, daydreaming, and dreaming.
几千年来,为了改变意识和感知,人类使用了种类繁多的植物衍生物质。在世界各地的文化中,无数的麻醉剂、镇痛药、“折磨”药物和其他精神活性物质被发现并用于仪式环境中,有一类物质尤其引人注目,不仅因为它对心理的激进影响,而且因为自大约50年前被广泛采用以来,围绕着它的高度紧张的政治和法律氛围:所谓的迷幻物质。我们回顾了迷幻体验的神经相关的功能神经成像研究,并强调了与创造力、白日梦和做梦的心理和神经基础的关系。
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引用次数: 15
What can topology tell us about the neural code 拓扑学能告诉我们关于神经编码的什么
Pub Date : 2016-05-06 DOI: 10.1090/BULL/1554
C. Curto
Neuroscience is undergoing a period of rapid experimental progress and expansion. New mathematical tools, previously unknown in the neuroscience community, are now being used to tackle fundamental questions and analyze emerging data sets. Consistent with this trend, the last decade has seen an uptick in the use of topological ideas and methods in neuroscience. In this talk I will survey recent applications of topology in neuroscience, and explain why topology is an especially natural tool for understanding neural codes. Note: This is a write-up of my talk for the Current Events Bulletin, held at the 2016 Joint Math Meetings in Seattle, WA.
神经科学正在经历一个快速实验进展和扩展的时期。新的数学工具,以前在神经科学界未知,现在被用来解决基本问题和分析新出现的数据集。与这一趋势相一致的是,在过去十年中,拓扑学思想和方法在神经科学中的应用有所增加。在这次演讲中,我将概述拓扑学在神经科学中的最新应用,并解释为什么拓扑学是理解神经编码的一个特别自然的工具。注:这是我为2016年在华盛顿州西雅图举行的联合数学会议上发表的《时事公报》发表的演讲。
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引用次数: 101
Quantum consciousness in warm, wet, and noisy brain 温暖、潮湿和嘈杂的大脑中的量子意识
Pub Date : 2016-04-01 DOI: 10.1142/S0217984916503292
V. Sbitnev
The emergence of quantum consciousness stems from dynamic flows of hydrogen ions in brain liquid. This liquid contains vast areas of the fourth phase of water with hexagonal packing of its molecules, the so-called exclusion zone (EZ) of water. The hydrogen ion motion on such hexagonal lattices shows as the hopping of the ions forward and the holes (vacant places) backward, caused by the Grotthuss mechanism. By supporting this motion using external infrasound sources, one may achieve the appearance of the superfluid state of the EZ water. Flows of the hydrogen ions are described by the modified Navier-Stokes equation. It, along with the continuity equation, yields the nonlinear Schrodinger equation, which describes the quantum effects of these flows, such as the tunneling at long distances or the interference on gap junctions.
量子意识的出现源于脑液中氢离子的动态流动。这种液体含有大量的水的第四相,其分子呈六边形排列,即所谓的水的禁区(EZ)。氢离子在这种六边形晶格上的运动表现为离子向前跳跃而空穴(空位)向后跳跃,这是由Grotthuss机制引起的。通过使用外部次声源支持这种运动,可以实现EZ水的超流体状态的外观。氢离子的流动用修正的Navier-Stokes方程来描述。它与连续性方程一起产生了非线性薛定谔方程,该方程描述了这些流动的量子效应,例如长距离的隧道效应或间隙连接上的干涉。
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引用次数: 20
The dual frequency RV-coupling coefficient: a novel measure for quantifying cross-frequency information transactions in the brain 双频rv耦合系数:一种量化大脑中交叉频率信息交易的新方法
Pub Date : 2016-03-17 DOI: 10.5167/UZH-123448
R. Pascual-Marqui, P. Faber, T. Kinoshita, Y. Kitaura, K. Kochi, P. Milz, K. Nishida, M. Yoshimura
Identifying dynamic transactions between brain regions has become increasingly important. Measurements within and across brain structures, demonstrating the occurrence of bursts of beta/gamma oscillations only during one specific phase of each theta/alpha cycle, have motivated the need to advance beyond linear and stationary time series models. Here we offer a novel measure, namely, the "dual frequency RV-coupling coefficient", for assessing different types of frequency-frequency interactions that subserve information flow in the brain. This is a measure of coherence between two complex-valued vectors, consisting of the set of Fourier coefficients for two different frequency bands, within or across two brain regions. RV-coupling is expressed in terms of instantaneous and lagged components. Furthermore, by using normalized Fourier coefficients (unit modulus), phase-type couplings can also be measured. The dual frequency RV-coupling coefficient is based on previous work: the second order bispectrum, i.e. the dual-frequency coherence (Thomson 1982; Haykin & Thomson 1998); the RV-coefficient (Escoufier 1973); Gorrostieta et al (2012); and Pascual-Marqui et al (2011). This paper presents the new measure, and outlines relevant statistical tests. The novel aspects of the "dual frequency RV-coupling coefficient" are: (1) it can be applied to two multivariate time series; (2) the method is not limited to single discrete frequencies, and in addition, the frequency bands are treated by means of appropriate multivariate statistical methodology; (3) the method makes use of a novel generalization of the RV-coefficient for complex-valued multivariate data; (4) real and imaginary covariance contributions to the RV-coherence are obtained, allowing the definition of a "lagged-coupling" measure that is minimally affected by the low spatial resolution of estimated cortical electric neuronal activity.
识别大脑区域之间的动态交易变得越来越重要。大脑结构内部和大脑结构之间的测量表明,只在每个θ / α周期的一个特定阶段才会出现β / γ振荡爆发,这促使人们需要超越线性和平稳时间序列模型。在这里,我们提供了一种新的测量方法,即“双频rv耦合系数”,用于评估不同类型的频率-频率相互作用,这些频率-频率相互作用促进了大脑中的信息流。这是测量两个复值向量之间的一致性,由两个不同频段的傅里叶系数集合组成,在两个大脑区域内或跨两个大脑区域。rv耦合用瞬时分量和滞后分量表示。此外,通过使用归一化傅里叶系数(单位模量),相位型耦合也可以测量。双频rv耦合系数基于先前的工作:二阶双谱,即双频相干性(Thomson 1982;Haykin & Thomson 1998);rv系数(Escoufier 1973);Gorrostieta et al (2012);Pascual-Marqui et al(2011)。本文介绍了新的测量方法,并概述了相关的统计检验。“双频rv耦合系数”的新颖之处在于:(1)它可以应用于两个多元时间序列;(2)该方法不局限于单个离散频率,此外,该频段通过适当的多元统计方法进行处理;(3)该方法对复值多变量数据的rv系数进行了新的推广;(4)获得了实协方差和虚协方差对rv相干性的贡献,允许定义“滞后耦合”测量,该测量受估计皮层电神经元活动的低空间分辨率影响最小。
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引用次数: 5
Extracting Blink Rate Variability from EEG Signals 从脑电信号中提取眨眼频率变异性
Pub Date : 2016-03-09 DOI: 10.18178/IJMLC.2016.6.3.597
R. Paprocki, Temesgen Gebrehiwot, Marija Gradinscak, Artem Lenskiy
Generally, blinks are treated on equal with artifacts and noise while analyzing EEG signals. However, blinks carry important information about mental processes and thus it is important to detect blinks accurately. The aim of the presented study is to propose a blink detection method and discuss its application for extracting blink rate variability, a novel concept that might shed some light on the mental processes. In this study, 14 EEG recordings were selected for assessing the quality of the proposed blink detection algorithm.
在分析脑电信号时,通常将眨眼与伪影和噪声同等对待。然而,眨眼携带着心理过程的重要信息,因此准确地检测眨眼是很重要的。本研究的目的是提出一种眨眼检测方法,并讨论其在提取眨眼频率变异性方面的应用,这是一个可能对心理过程有所启发的新概念。在这项研究中,选择了14个EEG记录来评估所提出的眨眼检测算法的质量。
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引用次数: 9
Information processing and Fechner's problem as a choice of arithmetic 作为算法选择的信息处理和费希纳问题
Pub Date : 2016-01-29 DOI: 10.1142/9789813109001_0012
M. Czachor
Fechner's law and its modern generalizations can be regarded as manifestations of alternative forms of arithmetic, coexisting at stimulus and sensation levels. The world of sensations may be thus described by a generalization of the standard mathematical calculus.
费希纳定律和它的现代概括可以看作是算术的不同形式的表现,在刺激和感觉水平上共存。因此,感觉世界可以用标准数学演算的概括来描述。
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引用次数: 8
期刊
arXiv: Neurons and Cognition
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