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Periodic event-triggered controller design with Bayesian optimization: An emulation-based approach 贝叶斯优化的周期性事件触发控制器设计:基于仿真的方法
IF 1.8 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-24 DOI: 10.1016/j.ifacsc.2024.100268
Kazumune Hashimoto

In recent years, event-triggered control has emerged as a promising strategy for addressing resource constraints in networked control systems (NCSs), such as limited life-time of battery capacity. This paper explores the development of a periodic event-triggered controller through a model-free design, assuming unknown plant dynamics. The design of the event-triggered controller employs an emulation-based approach, which is divided into solving two sub-problems: the problem for designing parameters for the time-triggered (periodic) control law, and the problem for designing parameters for the event-triggered condition. In particular, both problems will be solved through the usage of two distinct Bayesian optimization algorithms. The first problem is addressed by adapting basic Bayesian optimization to include network utilization by considering the number of communication time steps during optimization. The second problem employs constrained Bayesian optimization to incorporate explicit performance constraints within the optimization process. A numerical example is provided to demonstrate the effectiveness of the proposed method.

近年来,事件触发控制已成为解决联网控制系统(NCS)中资源限制(如电池容量寿命有限)的一种有前途的策略。本文在假设未知工厂动力学的前提下,通过无模型设计探讨了周期性事件触发控制器的开发。事件触发控制器的设计采用基于仿真的方法,分为两个子问题:时间触发(周期性)控制法则参数设计问题和事件触发条件参数设计问题。具体而言,这两个问题都将通过使用两种不同的贝叶斯优化算法来解决。第一个问题是通过调整基本贝叶斯优化算法,在优化过程中考虑通信时间步数,从而将网络利用率包括在内。第二个问题采用约束贝叶斯优化法,在优化过程中加入明确的性能约束。我们提供了一个数值示例来证明所提方法的有效性。
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引用次数: 0
Analysis on the contribution of glucagon receptors to glucose dynamics in type 1 diabetes 分析胰高血糖素受体对 1 型糖尿病患者血糖动态的影响
IF 1.8 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-24 DOI: 10.1016/j.ifacsc.2024.100272
Clara Furió-Novejarque , Iván Sala-Mira , Ajenthen G. Ranjan , Kirsten Nørgaard , José-Luis Díez , John Bagterp Jørgensen , Jorge Bondia

The glucagon effect is understudied in type 1 diabetes (T1D) simulators, without a clear consensus on the pharmacodynamics of glucagon over glucose. Glucagon receptors dynamics could present a significant contribution to T1D simulators, making them more physiologically accurate without an excessive increase in complexity. This work analyzes the receptors model contributions to glucose dynamics using a model proposed in previous work. Then, the model is assessed from two different perspectives: (1) A clinical dataset of the influence of diet (high or low carbohydrate content) on two consecutive glucagon doses (100 and 500 μg) is used to identify the model parameters and (2) three other glucagon action models from the literature are also identified to serve as comparators. Different identification methods are used to adapt to the distinctive features of the dataset. The root mean square error (RMSE) and the Akaike Information Criterion (AIC) were the discerning metrics used to compare the models fittings. Results show that the receptors model offers the lowest RMSE and AIC in contrast to the comparators. This model will hence be helpful in the development of accurate T1D simulators.

在 1 型糖尿病(T1D)模拟器中,对胰高血糖素效应的研究不足,对胰高血糖素相对于葡萄糖的药效学尚未达成明确共识。胰高血糖素受体动力学可为 T1D 模拟器做出重大贡献,使模拟器在不增加过多复杂性的情况下更符合生理学原理。这项工作利用之前工作中提出的模型分析了受体模型对葡萄糖动力学的贡献。然后,从两个不同的角度对模型进行评估:(1) 使用饮食(高或低碳水化合物含量)对两个连续胰高血糖素剂量(100 和 500 μg)影响的临床数据集来确定模型参数;(2) 还从文献中确定了其他三个胰高血糖素作用模型作为比较对象。为适应数据集的显著特点,采用了不同的识别方法。均方根误差(RMSE)和阿凯克信息准则(AIC)是用于比较模型拟合的判别指标。结果显示,与其他比较模型相比,受体模型的 RMSE 和 AIC 最低。因此,该模型将有助于开发精确的 T1D 模拟器。
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引用次数: 0
Improving breathing effort estimation in mechanical ventilation via optimal experiment design 通过优化实验设计改进机械通气中的呼吸努力估算
IF 1.8 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-24 DOI: 10.1016/j.ifacsc.2024.100270
Lars van de Kamp , Bram Hunnekens , Nathan van de Wouw , Tom Oomen

Estimation of the breathing effort and relevant lung parameters of a ventilated patient is essential to keep track of a patient’s clinical condition. The aim of this paper is to increase estimation accuracy through experiment design. The main method is an experiment design approach across multiple breaths within a linear regression framework to accurately identify the patient’s condition. Identifiability and persistence of excitation are used to formulate an estimation problem with a unique solution. Furthermore, Fisher information is used for assessing the parameters sensitivity to slight changes of the ventilator settings to improve the variance of the estimation. The estimation method is applied to simulated patients who breathe regularly but also to patients who have variable breathing patterns. A virtual experiment is conducted for both situations to generate estimation results. The results are analyzed using mathematical tools and show that uniquely estimating the lung parameters and breathing effort over multiple breaths for both regularly and variably breathing patients is possible in the presented framework. The proposed estimation method obtains clinically relevant estimates for a large set of breathing disturbances from the simulation case-study.

估算通气病人的呼吸强度和相关肺部参数对于跟踪病人的临床状况至关重要。本文旨在通过实验设计提高估算的准确性。主要方法是在线性回归框架内进行多次呼吸的实验设计方法,以准确识别病人的病情。可识别性和激励持续性被用来制定一个具有唯一解决方案的估计问题。此外,费雪信息还用于评估参数对呼吸机设置轻微变化的敏感性,以提高估算的方差。该估算方法不仅适用于有规律呼吸的模拟病人,也适用于呼吸模式多变的病人。对这两种情况都进行了虚拟实验,以得出估算结果。使用数学工具对结果进行了分析,结果表明,在所提出的框架中,可以对规律呼吸和可变呼吸患者的肺部参数和多次呼吸的呼吸强度进行唯一估算。所提出的估算方法可从模拟案例研究中获得大量呼吸干扰的临床相关估算结果。
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引用次数: 0
Ellipsoidal estimation of motion parameters of a non-cooperative space vehicle from visual information 根据视觉信息对非合作空间飞行器运动参数的椭圆形估计
IF 1.8 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-10 DOI: 10.1016/j.ifacsc.2024.100267
Nikolay Salnikov , Serhii Melnychuk , Vyacheslav Gubarev , Oleksii Sholokhov

The use of near-Earth space is currently complicated by presence of space debris objects in Earth’s orbit, which include spent stages of launch vehicles, inoperative satellites, and other large and small artificial objects. One approach to solving the problem of space debris involves docking and capturing a non-cooperative space object or spacecraft (target) with a so-called service spacecraft (chaser) for further actions to repair, refuel or change its orbit. Rendezvous and docking are complicated by the rotation of uncontrolled space objects caused by various factors. To perform this task, it is necessary to know the parameters of the orbital, rotational and relative motion of the target. The parameters of the orbital motion of such objects are usually known quite accurately from measurements from the Earth. This paper examines the case of a tumbling non-cooperative target located in an elliptical orbit. It is assumed that the target relative position and orientation are measured by the computer vision system (CVS) of the chaser. In this case, the position and orientation of the graphical reference frame (GRF) associated with the known 3-D graphical model of the target are determined relative to the reference frame associated with the chaser. The specific type of CVS is not considered. It is assumed that the chaser can carry out some maneuvers near the target and all parameters of the chaser angular motion are known. Thus, the attitude of the GRF relative to inertial reference frame (IRF) can be determined. The measured parameters are not enough to ensure safe rendezvous and docking with the target. To complete this task, it is necessary to determine all kinematic and dynamic parameters of the relative motion between the spacecraft. The rest of the required parameters are estimated. Orientation and rotation parameterization is done using quaternions. The angular motion equation of the target is considered in the GRF. This makes the angular velocity estimation faster and the inertia tensor estimation more stable. Stochastic characteristics of measurement errors are considered to be unknown and are not used. The only information about the errors is the bounds of their values. To determine the relative motion parameters, we use a new dynamic set-membership filter with ellipsoidal estimates. The filter can be successfully implemented on low-power on-board processors. The properties of the proposed algorithm are demonstrated using numerical simulation. The results obtained are expected to be used in the development of a navigation system for the rendezvous and docking, developed by a group of Ukrainian space industry enterprises under the leadership of the LLC “Kurs-orbital” (https://kursorbital.com/).

目前,由于地球轨道上存在空间碎片物体,包括运载火箭的废级、不能工作的卫星和其他大小人造物体,近地空间的利用变得复杂起来。解决空间碎片问题的一种方法是将不合作的空间物体或航天器(目标)与所谓的服务航天器(追逐者)对接并捕获,以便采取进一步行动进行维修、补充燃料或改变其轨道。由于各种因素导致不受控制的空间物体旋转,因此会使会合和对接变得复杂。要完成这项任务,就必须知道目标的轨道、旋转和相对运动参数。这类物体的轨道运动参数通常可以通过从地球上进行的测量而相当准确地获知。本文研究了位于椭圆轨道上的翻滚非合作目标的情况。假设目标的相对位置和方向是由追逐者的计算机视觉系统(CVS)测量的。在这种情况下,与已知目标的三维图形模型相关联的图形参考框架(GRF)的位置和方向是相对于与追逐者相关联的参考框架确定的。不考虑 CVS 的具体类型。假设追逐者可以在目标附近进行一些机动操作,并且追逐者角运动的所有参数都是已知的。因此,可以确定 GRF 相对于惯性参考框架(IRF)的姿态。测量到的参数不足以确保与目标的安全交会和对接。要完成这项任务,必须确定航天器之间相对运动的所有运动学和动力学参数。其余所需的参数则需要估算。方向和旋转参数的确定使用四元数。在 GRF 中考虑了目标的角运动方程。这使得角速度估算更快,惯性张量估算更稳定。测量误差的随机特征被认为是未知的,因此没有使用。关于误差的唯一信息是其值的边界。为了确定相对运动参数,我们使用了一种带有椭圆估计值的新型动态集合成员滤波器。该滤波器可在低功耗车载处理器上成功实现。我们通过数值模拟演示了所提算法的特性。获得的结果有望用于交会对接导航系统的开发,该系统由 "Kurs-orbital "有限责任公司(https://kursorbital.com/)领导下的乌克兰航天工业企业集团开发。
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引用次数: 0
Exploring variable observational time windows for patient–ventilator​ asynchrony during mechanical ventilation treatment 探索机械通气治疗期间患者与呼吸机不同步的可变观察时间窗
IF 1.9 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-04 DOI: 10.1016/j.ifacsc.2024.100266
Christopher Yew Shuen Ang , Yeong Shiong Chiew , Xin Wang , Ean Hin Ooi , Mohd Basri Mat Nor , Matthew E. Cove , J. Geoffrey Chase
<div><h3>Background and Objective:</h3><p>Patient–ventilator asynchrony (PVA) is prevalent in mechanical ventilation (MV) for critically ill patients and has been associated with adverse patient outcomes. However, studies investigating the associations between PVA and patient outcomes employ differing time windows for PVA evaluation. In this study, machine learning methods are used to quantify the prevalence and magnitude of asynchrony at different time windows, as well as its temporal trends. The study aims to identify the optimal time window for assessing the temporal changes in the asynchrony index (AI) and magnitude of asynchrony (<span><math><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></math></span>).</p></div><div><h3>Methods:</h3><p>This study uses Convolutional Neural Networks (CNN) and Convolutional Autoencoders (CAE) to detect incidences of PVA and quantify its severity in 30 MV respiratory failure patients with 2722 h of respiratory data. The frequency of PVA and the breath-average magnitude were determined over different time periods, <em>t</em>, where <span><math><mrow><mi>t</mi><mo>=</mo><mn>0</mn><mo>.</mo><mn>5</mn></mrow></math></span>, 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 45, 60 min and throughout MV. The AI for the patients was determined using the CNN model. Given an asynchronous breath, the CAEs were used to reconstruct asynchrony-free waveforms. The <span><math><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></math></span> was quantified as the difference between the two waveforms. The change in AI (<span><math><mi>Δ</mi></math></span>AI) and the change in <span><math><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></math></span>(<span><math><mrow><mi>Δ</mi><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></mrow></math></span>) for all time windows, <em>t</em> were also calculated for each patient.</p></div><div><h3>Results:</h3><p>The median [interquartile range] overall AI and <span><math><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></math></span> for the patient cohort are 24.8 [12.9–46.1]% and 37.2 [33.4–45.3]% respectively. Analysis of the patient cohort also shows significant intra-patient variability in AI and <span><math><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></math></span>, while the inter-patient variation in AI is greater as compared to <span><math><msub><mrow><mi>M</mi></mrow><mrow><mi>a</mi><mi>s</mi><mi>y</mi><mi>n</mi><mo>,</mo><mi>a</mi><mi>v</mi><mi>g</mi></mrow></msub></math></span>. The cohort mean <span><math><mi>Δ
背景和目的:重症患者机械通气(MV)中普遍存在患者-呼吸机不同步(PVA)现象,并与患者的不良预后有关。然而,调查 PVA 与患者预后之间关系的研究采用了不同的 PVA 评估时间窗。本研究采用机器学习方法来量化不同时间窗的不同步发生率和程度及其时间趋势。方法:本研究使用卷积神经网络(CNN)和卷积自动编码器(CAE)检测 30 名中风呼吸衰竭患者 2722 小时呼吸数据中的 PVA 发生率并量化其严重程度。在不同的时间段 t(t=0.5、1、2、3、4、5、10、15、20、25、30、45、60 分钟和整个中压期间)内确定了 PVA 的频率和呼吸平均幅度。患者的人工指数是通过 CNN 模型确定的。对于不同步呼吸,CAEs 被用来重建无不同步波形。Masyn,avg 被量化为两个波形之间的差值。结果:患者群的总 AI 和 Masyn,avg 的中位数[四分位间范围]分别为 24.8 [12.9-46.1] % 和 37.2 [33.4-45.3]%。对患者队列的分析还显示,AI 和 Masyn,avg 在患者内部存在显著差异,而与 Masyn,avg 相比,AI 在患者之间的差异更大。 患者队列的平均 ΔAI 和 ΔMasyn,avg 呈收敛趋势,在 t=5 分钟时达到最小值,分别为 5.32 ± 2.37% 和 2.80 ± 1.03%。对 AI 和 Masyn,avg 的评估首选 t=5 分钟的时间窗,因为它既能捕捉到不同步的细微变化,又能代表更长的时间趋势,从而防止患者 AI 和 Masyn,avg 的过度变化。通过了解这些模式,医疗服务提供者可以加强对心肌梗死的监测,从而采取更明智、更及时的干预措施。最终,这将改善患者护理和治疗效果。
{"title":"Exploring variable observational time windows for patient–ventilator​ asynchrony during mechanical ventilation treatment","authors":"Christopher Yew Shuen Ang ,&nbsp;Yeong Shiong Chiew ,&nbsp;Xin Wang ,&nbsp;Ean Hin Ooi ,&nbsp;Mohd Basri Mat Nor ,&nbsp;Matthew E. Cove ,&nbsp;J. Geoffrey Chase","doi":"10.1016/j.ifacsc.2024.100266","DOIUrl":"https://doi.org/10.1016/j.ifacsc.2024.100266","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background and Objective:&lt;/h3&gt;&lt;p&gt;Patient–ventilator asynchrony (PVA) is prevalent in mechanical ventilation (MV) for critically ill patients and has been associated with adverse patient outcomes. However, studies investigating the associations between PVA and patient outcomes employ differing time windows for PVA evaluation. In this study, machine learning methods are used to quantify the prevalence and magnitude of asynchrony at different time windows, as well as its temporal trends. The study aims to identify the optimal time window for assessing the temporal changes in the asynchrony index (AI) and magnitude of asynchrony (&lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods:&lt;/h3&gt;&lt;p&gt;This study uses Convolutional Neural Networks (CNN) and Convolutional Autoencoders (CAE) to detect incidences of PVA and quantify its severity in 30 MV respiratory failure patients with 2722 h of respiratory data. The frequency of PVA and the breath-average magnitude were determined over different time periods, &lt;em&gt;t&lt;/em&gt;, where &lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;t&lt;/mi&gt;&lt;mo&gt;=&lt;/mo&gt;&lt;mn&gt;0&lt;/mn&gt;&lt;mo&gt;.&lt;/mo&gt;&lt;mn&gt;5&lt;/mn&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;, 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 45, 60 min and throughout MV. The AI for the patients was determined using the CNN model. Given an asynchronous breath, the CAEs were used to reconstruct asynchrony-free waveforms. The &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; was quantified as the difference between the two waveforms. The change in AI (&lt;span&gt;&lt;math&gt;&lt;mi&gt;Δ&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;AI) and the change in &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;\u0000(&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mi&gt;Δ&lt;/mi&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) for all time windows, &lt;em&gt;t&lt;/em&gt; were also calculated for each patient.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results:&lt;/h3&gt;&lt;p&gt;The median [interquartile range] overall AI and &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt; for the patient cohort are 24.8 [12.9–46.1]% and 37.2 [33.4–45.3]% respectively. Analysis of the patient cohort also shows significant intra-patient variability in AI and &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;, while the inter-patient variation in AI is greater as compared to &lt;span&gt;&lt;math&gt;&lt;msub&gt;&lt;mrow&gt;&lt;mi&gt;M&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;s&lt;/mi&gt;&lt;mi&gt;y&lt;/mi&gt;&lt;mi&gt;n&lt;/mi&gt;&lt;mo&gt;,&lt;/mo&gt;&lt;mi&gt;a&lt;/mi&gt;&lt;mi&gt;v&lt;/mi&gt;&lt;mi&gt;g&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;. The cohort mean &lt;span&gt;&lt;math&gt;&lt;mi&gt;Δ","PeriodicalId":29926,"journal":{"name":"IFAC Journal of Systems and Control","volume":"29 ","pages":"Article 100266"},"PeriodicalIF":1.9,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468601824000270/pdfft?md5=094888b14f6d15c2cd2308a4be54717c&pid=1-s2.0-S2468601824000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141303150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrode module for EIT with a robust howland current source 用于 EIT 的电极模块,配有坚固耐用的 Howland 电流源
IF 1.9 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-06-01 DOI: 10.1016/j.ifacsc.2024.100265
Rafael B. Santos , André L. Santos , André C.M. Cavalheiro , Rafael A.O. Ferro , Fernando S. Moura , Raul G. Lima , Thiago C. Martins , Marcos S.G. Tsuzuki

Electrical Impedance Tomography (EIT) is a non-invasive imaging technique that reconstructs internal conductivity distributions of a body from electrical measurements taken on its boundary. This study contributes to the field by focusing on the technological intricacies of absolute EIT imaging, which is challenged by limitations such as the resolution capacity of the hardware and the complexities introduced by imaging capacitive bodies. The novel EIT system architecture proposed enhances the accuracy of measurement by integrating current sources and Analog-to-Digital Converters (ADCs) closer to the electrodes, employing alternating current excitations to accurately capture phase information. This system uses a dynamic arrangement of surface electrodes that continuously alter their roles between current injection and voltage measurement, in a synchronized sequence, to ensure the accuracy of the measurements. The paper describes the design and implementation of both the excitation and measurement subsystems, highlighting the use of digital signal demodulation near the electrode to reduce data transfer issues. Experimental results confirm the system’s capability for real-time image reconstruction at 50 frames per second with precision in phase delay measurements, suggesting significant potential for clinical and industrial applications. Future work will aim to further refine signal generation with higher-speed DACs and expand to image reconstruction with more channels.

电阻抗断层成像(EIT)是一种非侵入式成像技术,可通过对人体边界的电学测量重建人体内部的电导率分布。这项研究侧重于绝对 EIT 成像技术的复杂性,为该领域做出了贡献。绝对 EIT 成像受到硬件分辨率和电容体成像复杂性等限制的挑战。所提出的新型 EIT 系统架构通过将电流源和模数转换器 (ADC) 集成到更靠近电极的位置,采用交变电流激励来准确捕捉相位信息,从而提高了测量的准确性。该系统使用表面电极的动态排列,在电流注入和电压测量之间以同步顺序不断改变其角色,以确保测量的准确性。论文介绍了激励和测量子系统的设计和实施,重点介绍了在电极附近使用数字信号解调以减少数据传输问题。实验结果证实,该系统能以每秒 50 帧的速度进行实时图像重建,并能精确测量相位延迟,这表明该系统在临床和工业应用方面具有巨大潜力。未来工作的目标是利用更高速的 DAC 进一步完善信号生成,并扩展到更多通道的图像重建。
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引用次数: 0
Assessing and minimizing the impact of an additive disturbance for human respiratory system impedance estimation 评估并最大限度地减少附加干扰对人体呼吸系统阻抗估算的影响
IF 1.9 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-05-29 DOI: 10.1016/j.ifacsc.2024.100264
Antoine Marchal , Andy Keymolen , Gerd Vandersteen , Frank Heck , Ben van den Elshout , John Lataire

Respiratory Oscillometry is a promising technique to provide information to medical practitioners on the respiratory system of a patient in a non-invasive fashion. It focuses on identifying the respiratory impedance between two signals: the air pressure and flow at the mouth opening. However, for conscious patients or lightly sedated ventilated patients, their respiratory effort such as breathing acts as a disturbance to the parameter estimation procedure. This paper is an extension to previous research published at the IFAC 2023 World Congress (Marchal et al., 2023) that proposed a method to estimate and remove this breathing disturbance using Gaussian Process Regression in the frequency domain. In this extension, Monte Carlo simulations are performed to validate the approach and to compare it to the Local Polynomial Method for breathing patients. In addition, measurements carried out on a lung emulator in a pressure-support ventilation mode provide further evidence of the method’s effectiveness at dealing with the disturbance experienced for ventilated patients. This is a step towards treating both breathing and ventilated patients using the same technique.

呼吸振荡测量法是一种很有前途的技术,能以非侵入性的方式向医疗从业人员提供病人呼吸系统的信息。它的重点是识别两个信号之间的呼吸阻抗:开口处的气压和气流。然而,对于意识清醒的患者或轻度镇静通气患者,他们的呼吸努力(如呼吸)会对参数估计过程造成干扰。本文是对之前在 IFAC 2023 世界大会上发表的研究(Marchal 等人,2023 年)的扩展,该研究提出了一种在频域中使用高斯过程回归来估计和消除这种呼吸干扰的方法。在这一扩展中,进行了蒙特卡罗模拟以验证该方法,并将其与针对呼吸患者的局部多项式方法进行比较。此外,在压力支持通气模式下对肺模拟器进行的测量进一步证明了该方法在处理通气患者所受干扰方面的有效性。这是使用相同技术治疗呼吸和通气病人的一个进步。
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引用次数: 0
Optimal switching for Networked Control Systems with information multiplexing 具有信息复用功能的网络控制系统的优化交换
IF 1.9 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-05-10 DOI: 10.1016/j.ifacsc.2024.100263
Harsh Oza , Irinel-Constantin Morărescu , Vineeth S. Varma , Ravi Banavar

In this article, we examine a Networked Control System (NCS) in which the plant and the controller communicate over a network subject to a certain communication constraint. The plant is described by discrete-time nonlinear dynamics subject to bounded disturbances. Due to an overloaded communication network, we assume that the control signal and the information from the plant (the measured output signal) cannot be transmitted simultaneously and are subject to a multiplexing constraint. The goal is to design a switching strategy that allows us to sequentially communicate given these constraints while optimizing a quadratic cost over a finite horizon. Consequently, we proceed by emulation and assume that a controller that satisfies performance requirements is already provided. The resulting optimization problem is observed to be an integer programming problem that is generally NP-complete, i.e., the complexity is exponential in the time horizon considered. To overcome this issue, we provide a different perspective on this problem than what has been presented by the community before. Our main contribution is to reformulate the problem with all its constraints to a form that renders it amenable to apply the discrete-time Pontryagin Maximum Principle to get the necessary conditions for the optimality of the control action sequence. These necessary conditions are then solved numerically by a multiple-shooting method. To validate the approach, we present some illustrative numerical experiments on an inverted pendulum. Different setups are considered and numerically analyzed: usage of a predictor when the output is not transmitted and usage of the previous value of the output when the new value is not transmitted, with or without the choice of non-transmission.

在本文中,我们研究了一种网络控制系统(NCS),在该系统中,工厂和控制器在一定的通信约束条件下通过网络进行通信。工厂由离散时间非线性动力学描述,受到有界干扰的影响。由于通信网络过载,我们假设控制信号和来自工厂的信息(测量输出信号)不能同时传输,并且受到多路复用约束。我们的目标是设计一种切换策略,使我们能够在这些限制条件下按顺序进行通信,同时在有限时间范围内优化二次成本。因此,我们通过仿真进行设计,并假设已经提供了满足性能要求的控制器。观察发现,由此产生的优化问题是一个整数编程问题,通常是 NP-complete,即复杂度是所考虑时间跨度的指数。为了解决这个问题,我们提供了一个与以往不同的视角。我们的主要贡献在于将该问题及其所有约束条件重新表述为一种形式,使其适合于应用离散时间庞特里亚金最大原则来获得控制行动序列最优性的必要条件。然后,这些必要条件将通过多重射击法进行数值求解。为了验证该方法,我们介绍了一些关于倒立摆的说明性数值实验。我们考虑了不同的设置并对其进行了数值分析:在不传输输出时使用预测器,以及在不传输新值时使用先前的输出值,无论是否选择不传输。
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引用次数: 0
Modeling and analyzing competitive epidemic diseases with partial and waning virus-specific and cross-immunity 模拟和分析具有部分和减弱病毒特异性和交叉免疫的竞争性流行疾病
IF 1.9 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-05-10 DOI: 10.1016/j.ifacsc.2024.100262
Lorenzo Zino , Mengbin Ye , Brian D.O. Anderson

In this paper, we consider a novel mathematical modeling framework for the spread of two competitive diseases in a well-mixed population. The proposed framework, which we term a bivirus SIRIS model, encapsulates key real-world features of natural immunity, accounting for different levels of (partial and waning) virus-specific and cross protection acquired after recovery. Formally, the proposed framework consists of a system of coupled nonlinear ordinary differential equations that builds on a classical bivirus susceptible–infected–susceptible model by means of the addition of further states to account for (temporarily) protected individuals. Through the analysis of the proposed framework and of two specializations, we offer analytical insight into how natural immunity can shape a wide range of complex emergent behaviors, including eradication of both diseases, survival of the fittest one, or even steady-state co-existence of the two diseases.

本文针对两种竞争性疾病在混合良好的人群中的传播,提出了一种新颖的数学建模框架。我们所提出的框架被称为双病毒 SIRIS 模型,它概括了现实世界中自然免疫的主要特征,考虑了不同程度的(部分和减弱的)病毒特异性保护和恢复后获得的交叉保护。从形式上看,所提出的框架由一个耦合非线性常微分方程系统组成,该系统建立在经典的双病毒易感-感染-易感模型基础上,通过增加进一步的状态来解释(暂时)受保护的个体。通过对所提出的框架和两种特殊情况的分析,我们深入分析了自然免疫如何塑造各种复杂的突发行为,包括两种疾病的根除、适者生存,甚至两种疾病的稳态共存。
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引用次数: 0
Design of reduced-order controllers for fluid flows using full-order controllers and Gaussian process regression 利用全阶控制器和高斯过程回归设计流体流动的降阶控制器
IF 1.9 Q3 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-04-25 DOI: 10.1016/j.ifacsc.2024.100261
Yasuo Sasaki, Daisuke Tsubakino

We propose a method to design reduced-order output-feedback controllers for fluid flows with the use of data produced by full-order controllers. First, the full-order controller is obtained by combining an ensemble Kalman filter (EnKF) and a model predictive controller (MPC) that are designed based on the Navier–Stokes equations. The full-order controller has high computational complexity and, therefore, is not suitable for real-time implementation. Hence, we use the full-order controller in offline numerical simulations to generate data for data-driven design of the reduced-order controller with low computational complexity. We find a reduced-order subspace of a closed-loop system under the full-order control from the data. This subspace underlies the reduced-order output-feedback controller. The reduced-order state-feedback law is obtained by approximating the full-order MPC with the use of its input/output data. The reduced-order observer is designed for a reduced-order model that is derived by using the Gaussian process regression (GPR). The GPR enables us to design the reduced-order observer which can evaluate uncertainty due to state-dependent residuals of the reduced-order model. We demonstrate the proposed method for a control problem of a flow around a cylinder at the Reynolds number 100. Numerical simulations reveal that the reduced-order controller performs as almost well as the full-order controller for a set of initial states. In addition, robustness of the reduced-order controller to a temporal disturbance that is not considered in the control design is confirmed in the simulations.

我们提出了一种利用全阶控制器产生的数据设计流体流动的降阶输出反馈控制器的方法。首先,通过组合基于纳维-斯托克斯方程设计的集合卡尔曼滤波器(EnKF)和模型预测控制器(MPC)获得全阶控制器。全阶控制器的计算复杂度较高,因此不适合实时实施。因此,我们在离线数值模拟中使用全阶控制器生成数据,以数据驱动设计计算复杂度较低的降阶控制器。我们从数据中找到了全阶控制下闭环系统的降阶子空间。该子空间是降阶输出反馈控制器的基础。利用全阶 MPC 的输入/输出数据对其进行近似,就能得到降阶状态反馈定律。降阶观测器是针对降阶模型设计的,而降阶模型是通过高斯过程回归(GPR)得出的。通过 GPR,我们设计出的降阶观测器可以评估降阶模型中与状态相关的残差引起的不确定性。我们针对雷诺数为 100 的圆柱体周围流动的控制问题演示了所提出的方法。数值模拟显示,在一组初始状态下,减阶控制器的性能几乎与全阶控制器相同。此外,简化阶次控制器对控制设计中未考虑的时间干扰的鲁棒性也在模拟中得到了证实。
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引用次数: 0
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IFAC Journal of Systems and Control
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