Beecha V Ramya, Nihal Amrohi, R. Patil, A. A. M., Anuradha G. Patil
Abstract Background:Abdominal masses always are mystery in clinical practice. Improvements have taken place in fine needle aspiration cytology with technical advances in imaging methods of ultrasound and CT. Aims:To study the utility of guided FNAC in the diagnosis of abdominal lesions and categories the abdominal lesions. To study cytological features of abdominal lesions and correlate with histopathological features wherever possible. Materials and methods: The study included 82 abdominal lesions. History, clinical features, radiological investigations were obtained in each case. USG or CT guidance was used and the FNA procedure was done. Smears were stained with Giemsa and viewed under the microscope for diagnosis. Diagnostic yield was 95%. Extra material obtained was given for cell block. Results: The age was from 14 years old to 82 years and majority of them were in the age group of 40 – 60 years. Male to female ratio is 1:1.1. Among 82 cases, 45 cases (54.87%) were malignant, followed by 17 cases (20.74%) benign, 14 cases (17.08%) inflammatory, 04 cases (4.87%) suspicious of malignancy and 02 cases (2.44%) unsatisfactory for evaluation. Majority of the cases are in liver and hepatocellular carcinoma was the most common malignant lesion. In 60 cases histopathological correlation was available and for these cases the diagnostic accuracy is 95%, sensitivity is 92.1%, specificity is 100% and p value is <0.001 which is highly significant. Conclusion:Abdominal fine needle aspiration cytology is simple, cost effective, rapid and repeatable procedure which helps in categorizing the abdominal lesions.
{"title":"Ultrasound /Computed tomography Guided Fine Needle Aspiration Cytology of Abdominal Lesions","authors":"Beecha V Ramya, Nihal Amrohi, R. Patil, A. A. M., Anuradha G. Patil","doi":"10.47799/pimr.1001.14","DOIUrl":"https://doi.org/10.47799/pimr.1001.14","url":null,"abstract":"Abstract\u0000 \u0000 Background:Abdominal masses always are mystery in clinical practice. Improvements have taken place in fine needle aspiration cytology with technical advances in imaging methods of ultrasound and CT.\u0000 \u0000 Aims:To study the utility of guided FNAC in the diagnosis of abdominal lesions and categories the abdominal lesions. To study cytological features of abdominal lesions and correlate with histopathological features wherever possible.\u0000 \u0000 Materials and \u0000 methods: The study included 82 abdominal lesions. History, clinical features, radiological investigations were obtained in each case. USG or CT guidance was used and the FNA procedure was done. Smears were stained with Giemsa and viewed under the microscope for diagnosis. Diagnostic yield was 95%. Extra material obtained was given for cell block.\u0000 \u0000 Results: The age was from 14 years old to 82 years and majority of them were in the age group of 40 – 60 years. Male to female ratio is 1:1.1. Among 82 cases, 45 cases (54.87%) were malignant, followed by 17 cases (20.74%) benign, 14 cases (17.08%) inflammatory, 04 cases (4.87%) suspicious of malignancy and 02 cases (2.44%) unsatisfactory for evaluation. Majority of the cases are in liver and hepatocellular carcinoma was the most common malignant lesion. In 60 cases histopathological correlation was available and for these cases the diagnostic accuracy is 95%, sensitivity is 92.1%, specificity is 100% and p value is <0.001 which is highly significant.\u0000 \u0000 Conclusion:Abdominal fine needle aspiration cytology is simple, cost effective, rapid and repeatable procedure which helps in categorizing the abdominal lesions.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45743107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objectives:To assess the feasibility of diagnostic hysteroscopy in the diagnosis of abnormal structure and pathological lesions in the uterine cavities of women presenting abnormal bleeding of the uterus. Methods: This is a Prospective Cross-sectional study conducted in the Department of Gynaecology at Prathima Institute Of Medical Sciences, Karimnagar: one hundred women presenting with Abnormal Uterine Bleeding, over a period of one year from December 2020 to November 2021, were subjected to the procedure. Results: The results of our study show that hysteroscopy has high accuracy for detecting the pathology in women with abnormal uterine bleeding, especially in benign lesions such as endometrial polyp and submucosal fibroid and it can be used as the first line diagnostic method for these abnormalities. Conclusion:Hysteroscopy provides a more accurate diagnosis than dilatation and curettage or ultrasonography alone to diagnose pathology in women with abnormal bleeding of the uterus. It is very sensitive for diagnosing intracavitary lesions like submucous myoma and endometrial polyp.
{"title":"Hysteroscopic Evaluation Of\u0000 \u0000 Abnormal Uterine Bleeding\u0000 \u0000 In A Tertiary Care Institute — \u0000 An \u0000 Observational Study","authors":"Suhasini Edavally","doi":"10.47799/pimr.1001.13","DOIUrl":"https://doi.org/10.47799/pimr.1001.13","url":null,"abstract":"Abstract\u0000 \u0000 Objectives:To assess the feasibility of diagnostic hysteroscopy in the diagnosis of abnormal structure and pathological lesions in the uterine cavities of women presenting abnormal bleeding of the uterus.\u0000 \u0000 Methods: This is a Prospective Cross-sectional study conducted in the Department of Gynaecology at Prathima Institute Of Medical Sciences, Karimnagar: one hundred women presenting with Abnormal Uterine Bleeding, over a period of one year from December 2020 to November 2021, were subjected to the procedure.\u0000 \u0000 Results: The results of our study show that hysteroscopy has high accuracy for detecting the pathology in women with abnormal uterine bleeding, especially in benign lesions such as endometrial polyp and submucosal fibroid and it can be used as the first line diagnostic method for these abnormalities.\u0000 \u0000 Conclusion:Hysteroscopy provides a more accurate diagnosis than dilatation and curettage or ultrasonography alone to diagnose pathology in women with abnormal bleeding of the uterus. It is very sensitive for diagnosing intracavitary lesions like submucous myoma and endometrial polyp.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49562182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tarun Kumar Suvvari, V. Kandi, D. B. A. M. R. Salibindla, Simhachalam Kutikuppala, C. Tsagkaris, Venkata Narayana Nithish Modala
Abstract Background COVID-19 vaccines provide concrete hope of mitigating the spread of the virus and enabling countries worldwide to resume financial and social activities disrupted by the pandemic. Several COVID 19 vaccines have already received approval from regulatory bodies across the world, the vaccine roll out has started and many countries are implementing mass vaccination campaigns. This study aims to evaluate the acceptability of COVID-19 vaccines and its predictors, along with the attitudes towards the vaccines among the general population of South India. Materials and Methods This study was conducted as an online survey during December 2020 and January 2021. A Self-administered pre-tested questionnaire was used for the survey. Excel 2019 and SPPS 24 were used for statistical analysis. Descriptive statistics were used, and a Chi-square test was performed. Results A total of 686 people have participated in this study, with a mean age of 30.4 years. 30.9% of study participants have already been infected with COVID-19. 76.2% responded 'yes' for accepting the COVID-19 vaccine, 69% responded to prefer 'routine' administration of the vaccine, and 50.1% were likely to take the COVID-19 vaccine 'as soon as possible' once available. Conclusion Public health authorities and policymakers need to streamline systematic interventions and awareness campaigns to improve the acceptance of COVID 19 vaccines and reduce vaccine hesitancy levels. Vaccination strategy should be targeted at the specific needs and attitudes of the concerned population. Reviving the trust in the vaccination procedures and outcomes and offering transparent information regarding the vaccines' efficacy and safety seem to be particularly importance for the population of our study.
{"title":"Acceptance of COVID-19 Vaccine A\u0000 mong Residents \u0000 of South India: A Cross-sectional Survey","authors":"Tarun Kumar Suvvari, V. Kandi, D. B. A. M. R. Salibindla, Simhachalam Kutikuppala, C. Tsagkaris, Venkata Narayana Nithish Modala","doi":"10.47799/pimr.0903.17","DOIUrl":"https://doi.org/10.47799/pimr.0903.17","url":null,"abstract":"Abstract\u0000 \u0000 Background\u0000 \u0000 COVID-19 vaccines provide concrete hope of mitigating the spread of the virus and enabling countries worldwide to resume financial and social activities disrupted by the pandemic. Several COVID 19 vaccines have already received approval from regulatory bodies across the world, the vaccine roll out has started and many countries are implementing mass vaccination campaigns. This study aims to evaluate the acceptability of COVID-19 vaccines and its predictors, along with the attitudes towards the vaccines among the general population of South India.\u0000 \u0000 Materials and Methods \u0000 \u0000 This study was conducted as an online survey during December 2020 and January 2021. A Self-administered pre-tested questionnaire was used for the survey. Excel 2019 and SPPS 24 were used for statistical analysis. Descriptive statistics were used, and a Chi-square test was performed. \u0000 \u0000 Results\u0000 \u0000 A total of 686 people have participated in this study, with a mean age of 30.4 years. 30.9% of study participants have already been infected with COVID-19. 76.2% responded 'yes' for accepting the COVID-19 vaccine, 69% responded to prefer 'routine' administration of the vaccine, and 50.1% were likely to take the COVID-19 vaccine 'as soon as possible' once available.\u0000 \u0000 Conclusion\u0000 \u0000 Public health authorities and policymakers need to streamline systematic interventions and awareness campaigns to improve the acceptance of COVID 19 vaccines and reduce vaccine hesitancy levels. Vaccination strategy should be targeted at the specific needs and attitudes of the concerned population. Reviving the trust in the vaccination procedures and outcomes and offering transparent information regarding the vaccines' efficacy and safety seem to be particularly importance for the population of our study.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49654228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Coronary artery disease is now becoming increasingly prevalent than before especially in younger age groups. We in the current study tried to evaluate the potential of 128 slice MDCT coronary angiography for the detection of stenotic coronary lesions by comparing the results of computed tomographic coronary angiography to a gold standard set by Conventional coronary angiography. Methods: A total of n=30 patients with clinically suspected Coronary artery disease. They were evaluated with 128 Slice CT Scanner (PHILIPS INGENUITY) and conventional coronary angiography. All patients were examined with a 128 slice MDCT scanner (Philips Ingenuity 128 slice Netherlands) using standard cardiac CT protocol. Gantry rotation time was 400 ms with a half sector acquisition protocol and multisector reconstruction permitting an effective temporal resolution between 50 and 200 ms depending on patient heart rate. Results: In the n=30 Patients included in the study with CCA, the n=450 coronary segments included in the study were found to contain a total number of n=138 stenoses among them non-significant stenoses. The accuracy of MDCT detection of coronary stenoses greater than 50% diameter of vessel lumen is about 94.78. When raising the threshold for stenosis from 50% to 70% of the vessel lumen, so that only hemodynamic relevant stenoses enter the evaluation, the sensitivity decreases from 88%. The MDCT detection in the patient group with heart rates below 60 beats per minute higher values for sensitivity 93% and specificity 97% were observed, compared to sensitivity 87% and specificity 93% of the patient group with heart rates above 60 beats per minute. Conclusion:The present study revealed that a high negative predictive value (98.08%)suggests that 128- Slice MDCT coronary angiography is a good screening modality for evaluation of patients with mild to intermediate-risk factors who might otherwise require invasive angiography.
{"title":"Evaluation of Diagnostic Performance of MDCT Coronary Angiography in Comparison with Conventional Coronary Angiography","authors":"Sachin Kumar","doi":"10.47799/pimr.0903.09","DOIUrl":"https://doi.org/10.47799/pimr.0903.09","url":null,"abstract":"Abstract\u0000 \u0000 Background: Coronary artery disease is now becoming increasingly prevalent than before especially in younger age groups. We in the current study tried to evaluate the potential of 128 slice MDCT coronary angiography for the detection of stenotic coronary lesions by comparing the results of computed tomographic coronary angiography to a gold standard set by Conventional coronary angiography.\u0000 \u0000 Methods: A total of n=30 patients with clinically suspected Coronary artery disease. They were evaluated with 128 Slice CT Scanner (PHILIPS INGENUITY) and conventional coronary angiography. All patients were examined with a 128 slice MDCT scanner (Philips Ingenuity 128 slice Netherlands) using standard cardiac CT protocol. Gantry rotation time was 400 ms with a half sector acquisition protocol and multisector reconstruction permitting an effective temporal resolution between 50 and 200 ms depending on patient heart rate.\u0000 \u0000 Results: In the n=30 Patients included in the study with CCA, the n=450 coronary segments included in the study were found to contain a total number of n=138 stenoses among them non-significant stenoses. The accuracy of MDCT detection of coronary stenoses greater than 50% diameter of vessel lumen is about 94.78. When raising the threshold for stenosis from 50% to 70% of the vessel lumen, so that only hemodynamic relevant stenoses enter the evaluation, the sensitivity decreases from 88%. The MDCT detection in the patient group with heart rates below 60 beats per minute higher values for sensitivity 93% and specificity 97% were observed, compared to sensitivity 87% and specificity 93% of the patient group with heart rates above 60 beats per minute.\u0000 \u0000 Conclusion:The present study revealed that a high negative predictive value (98.08%)suggests that 128- Slice MDCT coronary angiography is a good screening modality for evaluation of patients with mild to intermediate-risk factors who might otherwise require invasive angiography.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49286376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objectives: The purpose of this study is to assess and compare the knowledge about the neonatal care among the mothers in urban and rural area in district Ajmer province of Rajasthan Materials and methods: Comparative randomized descriptive study was conducted among mothers who willingly gave consent to participate in the study. A structured questionnaire were framed and mothers were interviewed, the answers were recorded. To judge the knowledge score of the mothers closed ended questions having four alternatives were also framed. One mark was allocated for correct response. Results: Among 5800 deliveries, 400 mothers (205 mothers were Urban and 195 mothers were from Rural area) were randomly selected. Mothers with Antenatal check-up had knowledge score of 61% compared to 24% who had no regular antenatal checkup. Knowledge about “Exclusive Breastfeeding” was 84.39% and 68.20% urban mothers and rural mothers and regarding adequacy was 73.17% in Urban and 44.61% in rural mothers. Knowledge about Hygiene was 89.75% and 53.33% in Urban and rural mothers. Skin care and baby bath was 28.29% and 18.46% in Urban and Rural mothers respectively. Knowledge about danger signs was 81.95% and 60% in Urban and Rural mothers respectively. Knowledge regarding immunization at birth was 70.7% and 35.89% in Urban and Rural mothers respectively. Conclusions: Main factors affecting the knowledge score of the mothers about neonatal care were Educational status and Antenatal checkup. Knowledge about adequacy of breastfeeding, Immunization at birth, Danger signs, Temperature maintenance and hygiene was less in rural mothers as compared to urban mothers.
{"title":"Comparative Study of Knowledge of Urban and Rural Mothers about Neonatal Care","authors":"Bairwa Rameshchand, Sangeeta Vb, N. S, Sagethya A","doi":"10.47799/pimr.0903.08","DOIUrl":"https://doi.org/10.47799/pimr.0903.08","url":null,"abstract":"Abstract\u0000 \u0000 Objectives: The purpose of this study is to assess and compare the knowledge about the neonatal care among the mothers in urban and rural area in district Ajmer province of Rajasthan\u0000 \u0000 Materials and methods: Comparative randomized descriptive study was conducted among mothers who willingly gave consent to participate in the study. A structured questionnaire were framed and mothers were interviewed, the answers were recorded. To judge the knowledge score of the mothers closed ended questions having four alternatives were also framed. One mark was allocated for correct response. \u0000 \u0000 Results: Among 5800 deliveries, 400 mothers (205 mothers were Urban and 195 mothers were from Rural area) were randomly selected. Mothers with Antenatal check-up had knowledge score of 61% compared to 24% who had no regular antenatal checkup. Knowledge about “Exclusive Breastfeeding” was 84.39% and 68.20% urban mothers and rural mothers and regarding adequacy was 73.17% in Urban and 44.61% in rural mothers. Knowledge about Hygiene was 89.75% and 53.33% in Urban and rural mothers. Skin care and baby bath was 28.29% and 18.46% in Urban and Rural mothers respectively. Knowledge about danger signs was 81.95% and 60% in Urban and Rural mothers respectively. Knowledge regarding immunization at birth was 70.7% and 35.89% in Urban and Rural mothers respectively.\u0000 \u0000 Conclusions: Main factors affecting the knowledge score of the mothers about neonatal care were Educational status and Antenatal checkup. Knowledge about adequacy of breastfeeding, Immunization at birth, Danger signs, Temperature maintenance and hygiene was less in rural mothers as compared to urban mothers.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46985277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rana Fatima, Rakesh Kumar, Amitesh Goud, Srikanth Muddhasani, S. Reddy, Gouri shankar Swarnalatha, M. Swain
Abstract The prevalence of chronic kidney disease (CKD) is rising in rural areas. Screening of high risk cases, early detection and referral by the physicians reduces the prevalence of kidney disease in the population. Hereditary disorders, Glomerular diseases, Obstructive nephropathies are common causes in CKD in rural areas. Kidney biopsy is an essential diagnostic tool in to diagnose glomerular diseases. This prospective study done at tertiary care teaching hospital between 2017 and 2020 to understand the profile of glomerular diseases in rural area. Forty patients were included in the Study. Primary glomerular disease (PGD) was present in 26 patients and Secondary glomerular disease (SGD) in 10 and primary tubulointerstitial pathology in 4 patients. The most common Secondary glomerular disease was lupus. Glomerular diseases are amenable to immunomodulatory therapy leading to change in clinical outcome of the disease. However, Kidney biopsy is underutilized particularly in elderly patients, hypertensive nephropathy patients, suspected non diabetic kidney disease and lupus patients. Financial and social issues play dominant role in the treatment plan of chronic diseases in rural areas. Regional registry of kidney biopsy of urban and rural areas separately helps in paving a way of understanding the profile of glomerular diseases and its prevention.
{"title":"Biopsy Proven Kidney Disease From A Rural Tertiary Care Centre — A Social And Epidemiological Perspective","authors":"Rana Fatima, Rakesh Kumar, Amitesh Goud, Srikanth Muddhasani, S. Reddy, Gouri shankar Swarnalatha, M. Swain","doi":"10.47799/pimr.0903.16","DOIUrl":"https://doi.org/10.47799/pimr.0903.16","url":null,"abstract":"Abstract\u0000 The prevalence of chronic kidney disease (CKD) is rising in rural areas. Screening of high risk cases, early detection and referral by the physicians reduces the prevalence of kidney disease in the population. Hereditary disorders, Glomerular diseases, Obstructive nephropathies are common causes in CKD in rural areas. Kidney biopsy is an essential diagnostic tool in to diagnose glomerular diseases. This prospective study done at tertiary care teaching hospital between 2017 and 2020 to understand the profile of glomerular diseases in rural area. Forty patients were included in the Study. Primary glomerular disease (PGD) was present in 26 patients and Secondary glomerular disease (SGD) in 10 and primary tubulointerstitial pathology in 4 patients. The most common Secondary glomerular disease was lupus. Glomerular diseases are amenable to immunomodulatory therapy leading to change in clinical outcome of the disease. However, Kidney biopsy is underutilized particularly in elderly patients, hypertensive nephropathy patients, suspected non diabetic kidney disease and lupus patients.\u0000 Financial and social issues play dominant role in the treatment plan of chronic diseases in rural areas. Regional registry of kidney biopsy of urban and rural areas separately helps in paving a way of understanding the profile of glomerular diseases and its prevention.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47499643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Thrombocytopenia accompanying acute febrile illnesses is a matter of concern because lack of prompt treatment could result in significant mortality. We in this study tried to evaluate the clinical profile of cases with acute fever and thrombocytopenia and determine the cause of fever with thrombocytopenia and the outcome of treatment of such patients in our hospital. Methods: A total of n=50 successive cases of acute febrile illness with thrombocytopenia following inclusion and exclusion criteria were included in this study. Clinical signs such as rashes, signs of dehydration, petechiae, jaundice, lymphadenopathy, hepatomegaly, splenomegaly, anemia, abdominal tenderness, altered sensorium, were noted. Investigations included CBP, ESR, LFT, RFT, serum electrolytes, Chest X-ray, USG abdomen were done. Other investigations included Dengue serology, Malaria, Widal, IgM for leptospirosis, sputum for AFB. Results: Out of n=50 patients with acute fever with thrombocytopenia, all of them had a definitive diagnosis with malaria (40%) as the commonest cause, followed by enteric fever (24%), viral fever (14%), septicemia (6%), dengue (14%), and leptospirosis (2%). 50% of the patients had platelet count in the range of 50, 000 – 1,00, 000 and 30% had platelet counts above 100000-150000. 8% of cases had platelet counts below 25000 and 12% had platelet counts between 25000-50000 at the time of admission. 10% mortality was observed. Conclusion: infections as the commonest cause of thrombocytopenia. Malaria, dengue enteric fever, leptospirosis, and other viral infections formed the major diseases in this group of population. The diagnosis of malaria was the common cause because of seasonal and regional variations. A definitive increase in platelet count was noted after the underlying cause was treated. Severe cases of septicemia with associated co-morbidities resulted in mortality.
{"title":"A Clinical Study of the Association of Thrombocytopenia with Acute Febrile Illness","authors":"Gangum Venkatreddy, Shireesha Gugloth","doi":"10.47799/pimr.0903.04","DOIUrl":"https://doi.org/10.47799/pimr.0903.04","url":null,"abstract":"Abstract\u0000 \u0000 Background: Thrombocytopenia accompanying acute febrile illnesses is a matter of concern because lack of prompt treatment could result in significant mortality. We in this study tried to evaluate the clinical profile of cases with acute fever and thrombocytopenia and determine the cause of fever with thrombocytopenia and the outcome of treatment of such patients in our hospital. \u0000 \u0000 Methods: A total of n=50 successive cases of acute febrile illness with thrombocytopenia following inclusion and exclusion criteria were included in this study. Clinical signs such as rashes, signs of dehydration, petechiae, jaundice, lymphadenopathy, hepatomegaly, splenomegaly, anemia, abdominal tenderness, altered sensorium, were noted. Investigations included CBP, ESR, LFT, RFT, serum electrolytes, Chest X-ray, USG abdomen were done. Other investigations included Dengue serology, Malaria, Widal, IgM for leptospirosis, sputum for AFB.\u0000 \u0000 Results: Out of n=50 patients with acute fever with thrombocytopenia, all of them had a definitive diagnosis with malaria (40%) as the commonest cause, followed by enteric fever (24%), viral fever (14%), septicemia (6%), dengue (14%), and leptospirosis (2%). 50% of the patients had platelet count in the range of 50, 000 – 1,00, 000 and 30% had platelet counts above 100000-150000. 8% of cases had platelet counts below 25000 and 12% had platelet counts between 25000-50000 at the time of admission. 10% mortality was observed.\u0000 \u0000 Conclusion: infections as the commonest cause of thrombocytopenia. Malaria, dengue enteric fever, leptospirosis, and other viral infections formed the major diseases in this group of population. The diagnosis of malaria was the common cause because of seasonal and regional variations. A definitive increase in platelet count was noted after the underlying cause was treated. Severe cases of septicemia with associated co-morbidities resulted in mortality.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48835459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Dexmedetomidine has been safely used as an adjuvant for subarachnoid block in obstetric as well as non-obstetric surgeries and was found to be effective without adverse effects. Hence, this study was conducted to determine the efficacy of intrathecal Dexmedetomidine for elective lower segment caesarean sections with reduction of local anesthetic dose. Objectives: This double blinded, randomized controlled study was designed to compare the effects of addition of Dexmedetomidine on 1) Sensory and motor block 2) Maternal hemodynamics 3) Post-operative analgesia and 4) Neonatal outcome. Methods: Eighty parturients were enrolled in study and randomized into two groups as of 40 each and named as Group D and Group B. Group D received 0.5% Hyperbaric Bupivacaine 9mg (1.8ml) + Dexmedetomidine 5µg (0.2ml of 25 µg per ml ) and for Group B received 0.5% Hyperbaric Bupivacaine 10mg (2ml) . Characteristics of block, maternal hemodynamics and neonatal outcome were recorded. P value <0.05 was considered as significant. Results: Sensory onset was rapid in D group as compared to B group (3.7 ± 1.1vs 4.5±1.2) and motor onset was also rapid in D group (3.8±2.0 vs 4.9 ±1.9) with 95% CI. Duration of analgesia was also significantly high in Group D (230.5±40.5 vs 145.1±28.5). No adverse maternal and fetal outcomes were reported. Conclusion: Intrathecal Dexmedetomidine with low dose bupivacaine for cesarean section hastens the sensory as well as motor onset without adversely affecting mother and neonate.
摘要简介：在产科和非产科手术中，右美托咪定已被安全地用作蛛网膜下腔阻滞的辅助药物，并且被发现是有效的，没有副作用。因此，本研究旨在确定鞘内注射右美托咪定在减少局部麻醉剂量的情况下对选择性下段剖腹产的疗效。目的：这项双盲随机对照研究旨在比较添加右美托咪定对1）感觉和运动阻滞2）母体血液动力学3）术后镇痛和4）新生儿结局的影响。方法：80名产妇被纳入研究，并随机分为两组，每组40人，分别命名为D组和B组。D组接受0.5%高压布比卡因9mg（1.8ml）+右美托咪定5µg（0.2ml，每ml 25µg），B组接受0.5%高压布比卡因10mg（2ml）。记录阻滞特征、母体血液动力学和新生儿结局。P值<0.05被认为是显著的。结果：与B组相比，D组的感觉发作迅速（3.7±1.1 vs 4.5±1.2），运动发作也迅速（3.8±2.0 vs 4.9±1.9），CI为95%。D组的镇痛持续时间也显著延长（230.5±40.5 vs 145.1±28.5）。没有不良的母体和胎儿结局报告。结论：鞘内注射右美托咪定和小剂量布比卡因用于剖宫产可加速感觉和运动发作，而不会对母亲和新生儿产生不利影响。
{"title":"Randomized Controlled Trial to Evaluate the Efficacy of Intrathecal Dexmedetomidine to Low dose hyperbaric 0.5% Bupivacaine in Elective Lower Segment Caesarean Section","authors":"Y. Borse, A. Patil, S. Thorat, R. Subhedar","doi":"10.47799/pimr.0903.12","DOIUrl":"https://doi.org/10.47799/pimr.0903.12","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Dexmedetomidine has been safely used as an adjuvant for subarachnoid block in obstetric as well as non-obstetric surgeries and was found to be effective without adverse effects. Hence, this study was conducted to determine the efficacy of intrathecal Dexmedetomidine for elective lower segment caesarean sections with reduction of local anesthetic dose.\u0000 \u0000 Objectives: This double blinded, randomized controlled study was designed to compare the effects of addition of Dexmedetomidine on 1) Sensory and motor block 2) Maternal hemodynamics 3) Post-operative analgesia and 4) Neonatal outcome.\u0000 \u0000 Methods: Eighty parturients were enrolled in study and randomized into two groups as of 40 each and named as Group D and Group B. Group D received 0.5% Hyperbaric Bupivacaine 9mg (1.8ml) + Dexmedetomidine 5µg (0.2ml of 25 µg per ml ) and for Group B received 0.5% Hyperbaric Bupivacaine 10mg (2ml) . Characteristics of block, maternal hemodynamics and neonatal outcome were recorded. P value <0.05 was considered as significant.\u0000 \u0000 Results: Sensory onset was rapid in D group as compared to B group (3.7 ± 1.1vs 4.5±1.2) and motor onset was also rapid in D group (3.8±2.0 vs 4.9 ±1.9) with 95% CI. Duration of analgesia was also significantly high in Group D (230.5±40.5 vs 145.1±28.5). No adverse maternal and fetal outcomes were reported.\u0000 \u0000 Conclusion: Intrathecal Dexmedetomidine with low dose bupivacaine for cesarean section hastens the sensory as well as motor onset without adversely affecting mother and neonate.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48033997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajjad Ali Hashmi Syed, Sadaf Tanveer Khan, J. Syed
Abstract Introduction: For Functional Endoscopic Sinus Surgery (FESS), the surgeon needs an accurate depiction of the anatomy of paranasal sinuses and their variations. Computed tomography (CT Scan) fulfills this requirement by providing detailed anatomy, the anatomical variants, and the extent of the disease in and around the Para nasal sinuses. The aim of this study is to show the anatomy of the Frontal sinus as delineated by the computed tomography. Materials and Methods: STUDY DESIGN: Cross section Descriptive Study. Out of 337 patients above 12 years of age who were referred for computed tomography of paranasal sinuses in the Dept. of Radio- Diagnosis, Govt. Medical College and Hospital from December 2015 till October 2017, 200 adults(males and females) were randomly selected.Of the 200 subjects studied 37(18.5%) subjects had hypoplastic/ non or poorly pneumatised frontal sinuses of which 31 (15.5%) were bilateral and 6 (3%) were unilateral i.e. on right side. Observations and results: Intra frontal cell were seen in about 64 (32%) subjects of which 26 (13%) on right side, 24 (12%) were on left side and 14 (7%) were bilateral. Extension of pneumatisation into crista galli was seen in 16 (8%) subjects and into orbital roof was seen in 6 (3%) subjects. Conclusion: The findings in this study show that anatomical variations in the Para nasal sinuses and nasal cavity are common. Computed tomography is fundamental radiologic investigation for diagnosis of the Sino nasal lesions or pre and post-surgical assessment.
{"title":"Use of Computed Tomography (CT scan) for delineating anatomy and variation of frontal Sinus before Functional Endoscopic Sinus Surgery","authors":"Sajjad Ali Hashmi Syed, Sadaf Tanveer Khan, J. Syed","doi":"10.47799/pimr.0903.13","DOIUrl":"https://doi.org/10.47799/pimr.0903.13","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: For Functional Endoscopic Sinus Surgery (FESS), the surgeon needs an accurate depiction of the anatomy of paranasal sinuses and their variations. Computed tomography (CT Scan) fulfills this requirement by providing detailed anatomy, the anatomical variants, and the extent of the disease in and around the Para nasal sinuses. The aim of this study is to show the anatomy of the Frontal sinus as delineated by the computed tomography. \u0000 \u0000 Materials and Methods: \u0000 \u0000 STUDY DESIGN: Cross section Descriptive Study. Out of 337 patients above 12 years of age who were referred for computed tomography of paranasal sinuses in the Dept. of Radio- Diagnosis, Govt. Medical College and Hospital from December 2015 till October 2017, 200 adults(males and females) were randomly selected.Of the 200 subjects studied 37(18.5%) subjects had hypoplastic/ non or poorly pneumatised frontal sinuses of which 31 (15.5%) were bilateral and 6 (3%) were unilateral i.e. on right side.\u0000 \u0000 Observations and results:\u0000 \u0000 Intra frontal cell were seen in about 64 (32%) subjects of which 26 (13%) on right side, 24 (12%) were on left side and 14 (7%) were bilateral. Extension of pneumatisation into crista galli was seen in 16 (8%) subjects and into orbital roof was seen in 6 (3%) subjects.\u0000 \u0000 Conclusion:\u0000 \u0000 The findings in this study show that anatomical variations in the Para nasal sinuses and nasal cavity are common. Computed tomography is fundamental radiologic investigation for diagnosis of the Sino nasal lesions or pre and post-surgical assessment.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49056011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Aim:The aim of the current study is to evaluate anti-anxiety and potentiating effect of Thiocolchicoside in animal models of anxiety. Methodology: A total of 24 (n=24) Swiss albino mice were procured, and they were divided into four groups of six mice in each. First group of mice (control) received 10 ml/kg-Normal Saline, second group (standard) received 2.0 mg/kg-Diazepam, test-1 received 1 mg/kg-Thiocolchicoside and test-2 received Thiocolchicoside (1mg/kg) + Diazepam (2mg/kg) for seven days per orally. All the mice were evaluated for anti-anxiety activity by Elevated Plus Maze (EPM) 60 minutes after the oral drug administration of drugs on day 1, 3 and 7 and later after a washout period of one month, same four groups of mice were screened by Light and Dark Arena (LDA) model after receiving respective drugs. Results: One-way ANOVA followed by Tukey’s Kramer test were applied for inter group comparison and correlation test for intra-group comparison. Results are expressed in mean ± SEM. In EPM, time spent in open arm for the control, standard, test- 1 and test-2 were 64.5±25.81, 128.33±17.6, 138±10.56 and 168.33±22.35 seconds respectively. There is statistically significant difference between standard (P=0.05), test-1 (P=0.05) and test-2 (P=0.03) when compared with control group. Similarly, time spent in closed arm for the control, standard, test-1 and test-2 were 238.83±20.41, 171.67± 17.6, 162±10.56 and 131.67±22.35 seconds respectively. In this, test-2 is statistically significant from the control group (P=0.05). The number of entries in the open arm for the control group, standard group, test-1 and test-2 were 3.5±1.64, 13.17±7.44, 21 ± 4.05 and 13.33 ± 2.16 respectively. There is statistically significant difference between standard (P=0.03), test-1 (P=0.02) and test-2 (P=0.03) with control. Similarly, number of entries to closed arm for the control, standard, test-1 and test-2 were 9.5±3.62, 16.33 ± 5.65, 16.33 ± 4.23 and 8.17 ± 1.72 respectively. The values obtained for the standard, test-1 and test-2 were not statistically significant (P=0.8). In LDA, time spent in light arena for the control, standard, test-1 and test-2 were 106.83±18.21, 163.5±21.66, 105.33 ± 11.57 and 125.17 ± 16.35 seconds respectively. Statistically significant difference between the control and the standard group (P=0.05) is noted. Time spent in dark arena for the control, standard, test-1 and test-2 were 193.17±18.21, 136.5±11.66, 194.67±15.57 and 174.83±16.35 seconds respectively. Here only standard group is statistically significant when compared with control (P=0.05). The number of entries in the light arena for the control, standard, test-1 and test-2 were 11.67 ± 1.37, 13.17 ± 2.48, 12 ± 2.61 and 11.67 ± 1.03 respectively. The number of entries in the dark arena for the control, standard, test-1 and test-2 were 12.17 ± 1.47, 13.17 ± 2.93, 11.83 ± 2.23 and 11 ± 0.89 respectively. With regard to number of entries in the light and dark arena t
摘要目的：本研究的目的是评估Thiocolchicoside在焦虑动物模型中的抗焦虑和增强作用。方法：共获得24只（n=24）瑞士白化病小鼠，将其分为四组，每组6只。第一组小鼠（对照组）接受10ml/kg生理盐水，第二组（标准组）接受2.0mg/kg地西泮，试验-1接受1mg/kg硫代秋水仙糖苷，试验-2接受1mg/kg Thiocolchicoside+2mg/kg地西泮口服7天。在第1天、第3天和第7天口服药物给药60分钟后，以及在一个月的冲洗期后，通过Elevated Plus Maze（EPM）对所有小鼠的抗焦虑活性进行评估，同样的四组小鼠在接受各自的药物后通过Light and Dark Arena（LDA）模型进行筛选。结果：单因素方差分析和Tukey’s Kramer检验用于组间比较，相关检验用于组内比较。结果用平均值±SEM表示。在EPM中，对照组、标准组、试验-1和试验-2在开放臂上花费的时间分别为64.5±25.81、128.33±17.6、138±10.56和168.33±22.35秒。与对照组相比，标准组（P=0.05）、试验-1组（P=0.005）和试验-2组（P=0.03）之间存在统计学显著差异。同样，对照组、标准组、试验-1和试验-2在闭合臂上花费的时间分别为238.83±20.41、171.67±17.6、162±10.56和131.67±22.35秒。其中，试验-2与对照组相比具有统计学意义（P=0.05）。对照组、标准组、试验-1和试验-2的开放臂条目数分别为3.5±1.64、13.17±7.44、21±4.05和13.33±2.16。标准组（P=0.03）、试验-1组（P=0.02）和试验-2组（P=0.003）与对照组之间存在统计学显著差异。同样，对照组、标准组、试验-1和试验-2进入闭合臂的次数分别为9.5±3.62、16.33±5.65、16.33士4.23和8.17±1.72。在LDA中，对照组、标准组、试验组1和试验组2在光场中花费的时间分别为106.83±18.21、163.5±21.66、105.33±11.57和125.17±16.35秒。对照组和标准组之间存在统计学上的显著差异（P=0.05）。对照组、标准组、试验-1和试验-2在黑暗环境中的时间分别为193.17±18.21、136.5±11.66、194.67±15.57和174.83±16.35秒。与对照组相比，只有标准组具有统计学意义（P=0.05）。对照组、标准组、测试-1和测试-2在光场的进入次数分别为11.67±1.37、13.17±2.48、12±2.61和11.67±1.03。对照组、标准组、试验-1和试验-2在黑暗区域的进入次数分别为12.17±1.47、13.17±2.93、11.83±2.23和11±0.89。就进入光明和黑暗领域的次数而言，两组之间没有统计学上的显著差异（P>0.05）。结论：研究结果清楚地表明，在EPM和LDA模型中，Thiocolchicoside（1mg/kg）与地西泮联合使用具有抗焦虑和额外增强作用。
{"title":"Potential role of Thiocolchicoside in anxiety disorder: A pre-clinical study","authors":"K. Gourav, Prabhakar Adake, R. Nayak","doi":"10.47799/pimr.0903.11","DOIUrl":"https://doi.org/10.47799/pimr.0903.11","url":null,"abstract":"Abstract\u0000 \u0000 Aim:The aim of the current study is to evaluate anti-anxiety and potentiating effect of Thiocolchicoside in animal models of anxiety.\u0000 \u0000 Methodology: A total of 24 (n=24) Swiss albino mice were procured, and they were divided into four groups of six mice in each. First group of mice (control) received 10 ml/kg-Normal Saline, second group (standard) received 2.0 mg/kg-Diazepam, test-1 received 1 mg/kg-Thiocolchicoside and test-2 received Thiocolchicoside (1mg/kg) + Diazepam (2mg/kg) for seven days per orally. All the mice were evaluated for anti-anxiety activity by Elevated Plus Maze (EPM) 60 minutes after the oral drug administration of drugs on day 1, 3 and 7 and later after a washout period of one month, same four groups of mice were screened by Light and Dark Arena (LDA) model after receiving respective drugs.\u0000 \u0000 Results: One-way ANOVA followed by Tukey’s Kramer test were applied for inter group comparison and correlation test for intra-group comparison. Results are expressed in mean ± SEM. In EPM, time spent in open arm for the control, standard, test- 1 and test-2 were 64.5±25.81, 128.33±17.6, 138±10.56 and 168.33±22.35 seconds respectively. There is statistically significant difference between standard (P=0.05), test-1 (P=0.05) and test-2 (P=0.03) when compared with control group. Similarly, time spent in closed arm for the control, standard, test-1 and test-2 were 238.83±20.41, 171.67± 17.6, 162±10.56 and 131.67±22.35 seconds respectively. In this, test-2 is statistically significant from the control group (P=0.05). The number of entries in the open arm for the control group, standard group, test-1 and test-2 were 3.5±1.64, 13.17±7.44, 21 ± 4.05 and 13.33 ± 2.16\u0000 respectively. There is statistically significant difference between standard (P=0.03), test-1 (P=0.02) and test-2 (P=0.03) with control. Similarly, number of entries to closed arm for the control, standard, test-1 and test-2 were 9.5±3.62, 16.33 ± 5.65, 16.33 ± 4.23 and 8.17 ± 1.72 respectively. The values obtained for the standard, test-1 and test-2 were not statistically significant (P=0.8). In LDA, time spent in light arena for the control, standard, test-1 and test-2 were 106.83±18.21, 163.5±21.66, 105.33 ± 11.57 and 125.17 ± 16.35 seconds respectively. Statistically significant difference between the control and the standard group (P=0.05) is noted. Time spent in dark arena for the control, standard, test-1 and test-2 were 193.17±18.21, 136.5±11.66, 194.67±15.57 and 174.83±16.35 seconds respectively. Here only standard group is statistically significant when compared with control (P=0.05). The number of entries in the light arena for the control, standard, test-1 and test-2 were 11.67 ± 1.37, 13.17 ± 2.48, 12 ± 2.61 and 11.67 ± 1.03 respectively. The number of entries in the dark arena for the control, standard, test-1 and test-2 were 12.17 ± 1.47, 13.17 ± 2.93, 11.83 ± 2.23 and 11 ± 0.89 respectively. With regard to number of entries in the light and dark arena t","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41832097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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