Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110093
Bing Li , Yinan Xu , Xueyan Guo , Meihui Wang , Xiaoyuan Li , Zhe Chen , Zhiwen Wei , Dong Ma , Keming Yun
PFAS are emerging persistent organic pollutants, and their potential impacts and underlying mechanisms on cognitive function remain incompletely understood. This study utilized a male rat model to investigate the effects of an environmentally relevant PFAS mixture comprised of eight PFAS on spatial learning and memory, as well as the potential mechanisms through molecular biology assays and multi-omics analysis. Following the administration of PFAS via oral gavage at doses of 0, 0.001, 0.050, 0.250 and 7.000 mg/kg body weight for 28 days, resulting in a decrease in object location recognition ability, spatial learning and memory, as assessed by the new location recognition and Morris water maze tests at the exposure endpoint. These impairments may be closely related to the dysregulation of neurotransmitter secretion, enhanced inflammatory responses, neuronal damage and apoptosis, and impaired intestinal barrier function. Furthermore, exosomal transcriptomics and plasma metabolomics analyses revealed that 17 miRNAs and 7 metabolites were associated with PFAS-induced neurotoxicity. Meanwhile, PFAS exposure led to alterations in gut microbial diversity, with correlations observed between changes in metabolites and bacteria. These synergistic effects contributed to neurotoxicity associated with PFAS, which may be closely linked to the microbiota-gut-brain axis. These findings provide valuable insights for assessing the neurotoxicity of PFAS at environmentally relevant concentrations.
{"title":"Identification of potential mechanisms of cognitive dysfunction induced by environmentally relevant PFAS mixture in male rats","authors":"Bing Li , Yinan Xu , Xueyan Guo , Meihui Wang , Xiaoyuan Li , Zhe Chen , Zhiwen Wei , Dong Ma , Keming Yun","doi":"10.1016/j.envint.2026.110093","DOIUrl":"10.1016/j.envint.2026.110093","url":null,"abstract":"<div><div>PFAS are emerging persistent organic pollutants, and their potential impacts and underlying mechanisms on cognitive function remain incompletely understood. This study utilized a male rat model to investigate the effects of an environmentally relevant PFAS mixture comprised of eight PFAS on spatial learning and memory, as well as the potential mechanisms through molecular biology assays and multi-omics analysis. Following the administration of PFAS via oral gavage at doses of 0, 0.001, 0.050, 0.250 and 7.000 mg/kg body weight for 28 days, resulting in a decrease in object location recognition ability, spatial learning and memory, as assessed by the new location recognition and Morris water maze tests at the exposure endpoint. These impairments may be closely related to the dysregulation of neurotransmitter secretion, enhanced inflammatory responses, neuronal damage and apoptosis, and impaired intestinal barrier function. Furthermore, exosomal transcriptomics and plasma metabolomics analyses revealed that 17 miRNAs and 7 metabolites were associated with PFAS-induced neurotoxicity. Meanwhile, PFAS exposure led to alterations in gut microbial diversity, with correlations observed between changes in metabolites and bacteria. These synergistic effects contributed to neurotoxicity associated with PFAS, which may be closely linked to the microbiota-gut-brain axis. These findings provide valuable insights for assessing the neurotoxicity of PFAS at environmentally relevant concentrations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110093"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110091
Xuedan Xu , Keqi Hu , Yingli Qu , Fengfeng Dong , Yihan Du , Daoqin Wang , Zheng Li , Feng Zhao , Wanying Shi , Yawei Li , Haocan Song , Yue Chen , Yitao Pan , Jiayin Dai , Qiuxia Chen , Nan Sheng , Yuebin Lv , Xiaoming Shi , Hongwei Tu
The association between perfluoroalkyl and polyfluoroalkyl substances (PFAS) and hemoglobin (Hb) in general population, as well as their structural–functional relationship remains to be elucidated. We examined both individual and joint-level associations of serum PFAS with Hb concentrations using data from the China National Human Biomonitoring Program. Molecular docking and quantum mechanics calculations were further applied to elucidate potential molecular mechanisms. Of 6,883 participants, median serum concentrations of 8 PFAS ranged from 0.15 ng/mL (perfluoroheptanesulfonic acid [PFHpS]) to 5.85 ng/mL (perfluorooctanesulfonic acid [PFOS]). All participants had Hb concentrations within the normal physiological range. PFAS mixture demonstrated negative relationship with the Hb in the general population, with perfluoroundecanoic acid (PFUnDA) emerging as the dominant contributor. Moreover, the effect sizes of inverse associations between perfluorocarboxylic acids (PFCAs) and Hb increased in magnitude with longer carbon chains, especially in females, while no such trend was observed for perfluorosulfonic acids (PFSAs). Notably, the PFOS alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonic Acid (Cl-PFESA) was inversely associated with Hb in females. Stronger associations were observed among females, individuals with lower body mass index, and those with higher meat consumption. Molecular modeling indicated that PFAS preferentially bind to the α subunit rather than the β subunit of Hb, and PFCAs exhibited similar binding affinities to heme comparable to that of oxygen, suggesting potential interference with Hb’s oxygen-binding capacity. Our findings revealed structure-dependent associations and interactions between PFAS and Hb, providing important insights for further mechanistic studies on PFAS-related hematotoxicity and highlight the urgent need to control PFAS exposure.
{"title":"Structure–dependent association between Perfluoroalkyl and polyfluoroalkyl substances and hemoglobin in the Chinese population: insights from epidemiological analysis and molecular simulations","authors":"Xuedan Xu , Keqi Hu , Yingli Qu , Fengfeng Dong , Yihan Du , Daoqin Wang , Zheng Li , Feng Zhao , Wanying Shi , Yawei Li , Haocan Song , Yue Chen , Yitao Pan , Jiayin Dai , Qiuxia Chen , Nan Sheng , Yuebin Lv , Xiaoming Shi , Hongwei Tu","doi":"10.1016/j.envint.2026.110091","DOIUrl":"10.1016/j.envint.2026.110091","url":null,"abstract":"<div><div>The association between perfluoroalkyl and polyfluoroalkyl substances (PFAS) and hemoglobin (Hb) in general population, as well as their structural–functional relationship remains to be elucidated. We examined both individual and joint-level associations of serum PFAS with Hb concentrations using data from the China National Human Biomonitoring Program. Molecular docking and quantum mechanics calculations were further applied to elucidate potential molecular mechanisms. Of 6,883 participants, median serum concentrations of 8 PFAS ranged from 0.15 ng/mL (perfluoroheptanesulfonic acid [PFHpS]) to 5.85 ng/mL (perfluorooctanesulfonic acid [PFOS]). All participants had Hb concentrations within the normal physiological range. PFAS mixture demonstrated negative relationship with the Hb in the general population, with perfluoroundecanoic acid (PFUnDA) emerging as the dominant contributor. Moreover, the effect sizes of inverse associations between perfluorocarboxylic acids (PFCAs) and Hb increased in magnitude with longer carbon chains, especially in females, while no such trend was observed for perfluorosulfonic acids (PFSAs). Notably, the PFOS alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonic Acid (Cl-PFESA) was inversely associated with Hb in females. Stronger associations were observed among females, individuals with lower body mass index, and those with higher meat consumption. Molecular modeling indicated that PFAS preferentially bind to the α subunit rather than the β subunit of Hb, and PFCAs exhibited similar binding affinities to heme comparable to that of oxygen, suggesting potential interference with Hb’s oxygen-binding capacity. Our findings revealed structure-dependent associations and interactions between PFAS and Hb, providing important insights for further mechanistic studies on PFAS-related hematotoxicity and highlight the urgent need to control PFAS exposure.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110091"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110106
Chien-Yu Lin , Hui-Ling Lee , Ta-Chen Su
Background
Evidence linking per- and polyfluoroalkyl substances (PFAS) to thyroid dysfunction is growing, yet longitudinal data spanning adolescence to early adulthood remained limited.
Methods
We analyzed 495 participants aged 12–30 years in the YOung TAiwanese Cohort (YOTA) followed for 9–12 years. 11 Plasma PFAS and serum thyroid-stimulating hormone (TSH) and free thyroxine (free T4) were measured at baseline and follow-up. PFAS exposure index was derived as the mean of these standardized ln-PFAS concentrations. Using multivariable ANCOVA-style linear regression models, we examined associations of baseline PFAS levels and changes in PFAS with follow-up ln-TSH and ln-free T4, and incident thyroid disease was examined using Cox models.
Results
In multivariable models, both higher baseline PFAS exposure index and a more positive change in PFAS exposure index were associated with lower follow-up TSH (−17.22%, p = 0.003; and − 16.81%, p = 0.011, respectively). Several baseline PFAS compounds showed inverse associations with follow-up TSH, including linear PFOA, linear PFOS, N-MeFOSAA, and PFHpA; inverse associations for PFAS changes were most evident for linear PFOA and linear PFOS. For free T4, baseline PFAS measures were not significant after FDR correction, whereas a more positive change in PFAS exposure index was associated with higher follow-up free T4 (+5.55%, p = 0.001), with nominal positive associations observed for linear PFOA and PFDoA. These patterns were robust in sensitivity analyses (including baseline-only/change-only specifications, change-score models, and exclusions of baseline/follow-up thyroid dysfunction). In Cox regression analyses, greater annualized increases in the PFAS exposure index were associated with lower risks of hypothyroidism and thyroid nodules.
Conclusions
PFAS exposure was associated with lower TSH and higher free T4 over 10 years of follow-up, suggesting sustained thyroid-axis perturbation from adolescence into young adulthood. These findings underscore a susceptible developmental window and support long-term biomonitoring and stronger regulatory action where PFAS contamination persists.
{"title":"Longitudinal PFAS exposure and thyroid function trajectories in Taiwanese youth: a 10-year prospective cohort study","authors":"Chien-Yu Lin , Hui-Ling Lee , Ta-Chen Su","doi":"10.1016/j.envint.2026.110106","DOIUrl":"10.1016/j.envint.2026.110106","url":null,"abstract":"<div><h3>Background</h3><div>Evidence linking per- and polyfluoroalkyl substances (PFAS) to thyroid dysfunction is growing, yet longitudinal data spanning adolescence to early adulthood remained limited.</div></div><div><h3>Methods</h3><div>We analyzed 495 participants aged 12–30 years in the YOung TAiwanese Cohort (YOTA) followed for 9–12 years. 11 Plasma PFAS and serum thyroid-stimulating hormone (TSH) and free thyroxine (free T4) were measured at baseline and follow-up. PFAS exposure index was derived as the mean of these standardized ln-PFAS concentrations. Using multivariable ANCOVA-style linear regression models, we examined associations of baseline PFAS levels and changes in PFAS with follow-up ln-TSH and ln-free T4, and incident thyroid disease was examined using Cox models.</div></div><div><h3>Results</h3><div>In multivariable models, both higher baseline PFAS exposure index and a more positive change in PFAS exposure index were associated with lower follow-up TSH (−17.22%, p = 0.003; and − 16.81%, p = 0.011, respectively). Several baseline PFAS compounds showed inverse associations with follow-up TSH, including linear PFOA, linear PFOS, N-MeFOSAA, and PFHpA; inverse associations for PFAS changes were most evident for linear PFOA and linear PFOS. For free T4, baseline PFAS measures were not significant after FDR correction, whereas a more positive change in PFAS exposure index was associated with higher follow-up free T4 (+5.55%, p = 0.001), with nominal positive associations observed for linear PFOA and PFDoA. These patterns were robust in sensitivity analyses (including baseline-only/change-only specifications, change-score models, and exclusions of baseline/follow-up thyroid dysfunction). In Cox regression analyses, greater annualized increases in the PFAS exposure index were associated with lower risks of hypothyroidism and thyroid nodules.</div></div><div><h3>Conclusions</h3><div>PFAS exposure was associated with lower TSH and higher free T4 over 10 years of follow-up, suggesting sustained thyroid-axis perturbation from adolescence into young adulthood. These findings underscore a susceptible developmental window and support long-term biomonitoring and stronger regulatory action where PFAS contamination persists.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110106"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110109
Hualong Zhen , Changmeng Liu , Dandan Sun , Xinyu Wang , Juan Tong , Guopeng Gao , Xiaoyan Wu , Hong Gan , Shanshan Du , Shuangqin Yan , Fangbiao Tao , Kun Huang
Microplastics (MPs) are widely present in the human world. This study aimed to explore the sex − specific associations between early-life MPs exposure and BMI as well as BMI z-scores in children. We enrolled 1,080 children aged 10 years from the Ma’anshan Birth Cohort in China. A Laser Direct Infrared instrument was used to detect the presence of 19 types of MPs in the children’s urine. Children’s height and weight were measured to calculate BMI and BMI z-scores. Linear regression, logistic regression, restricted cubic spline regression, and Quantile g-computation regression were employed to investigate the associations between the MPs and children’s BMI and BMI z-scores. The results demonstrated the overall detection rate of MPs was 91.1%, with PTFE exhibiting the highest rate at 49.9%. Elevated levels of PE, PAM, and small-size MPs in urine were associated with increased risks of overweight/obesity in boys (OR = 1.156, 95% CI: 1.048, 1.274; OR = 1.278, 95% CI: 1.159, 1.409; OR = 1.114, 95% CI: 1.007, 1.233). PA and PE levels were associated with an increased risk of girls’ overweight/obesity (OR = 1.150, 95% CI: 1.055, 1.252; OR = 1.226, 95% CI: 1.126, 1.335). PAM and PE exposures were associated with underweight risk in boys and girls, respectively. Moreover, PTFE levels were positively associated with higher BMI z-scores in boys (β = 0.052, 95% CI: 0.003, 0.101). Significant sex-specific associations were observed between exposure to specific MPs and both BMI categories and BMI z-scores in children.
{"title":"Sex-specific associations between early-life microplastic exposure and children’s physical development: Evidence from a study in China","authors":"Hualong Zhen , Changmeng Liu , Dandan Sun , Xinyu Wang , Juan Tong , Guopeng Gao , Xiaoyan Wu , Hong Gan , Shanshan Du , Shuangqin Yan , Fangbiao Tao , Kun Huang","doi":"10.1016/j.envint.2026.110109","DOIUrl":"10.1016/j.envint.2026.110109","url":null,"abstract":"<div><div>Microplastics (MPs) are widely present in the human world. This study aimed to explore the sex − specific associations between early-life MPs exposure and BMI as well as BMI z-scores in children. We enrolled 1,080 children aged 10 years from the Ma’anshan Birth Cohort in China. A Laser Direct Infrared instrument was used to detect the presence of 19 types of MPs in the children’s urine. Children’s height and weight were measured to calculate BMI and BMI z-scores. Linear regression, logistic regression, restricted cubic spline regression, and Quantile g-computation regression were employed to investigate the associations between the MPs and children’s BMI and BMI z-scores. The results demonstrated the overall detection rate of MPs was 91.1%, with PTFE exhibiting the highest rate at 49.9%. Elevated levels of PE, PAM, and small-size MPs in urine were associated with increased risks of overweight/obesity in boys (OR = 1.156, 95% CI: 1.048, 1.274; OR = 1.278, 95% CI: 1.159, 1.409; OR = 1.114, 95% CI: 1.007, 1.233). PA and PE levels were associated with an increased risk of girls’ overweight/obesity (OR = 1.150, 95% CI: 1.055, 1.252; OR = 1.226, 95% CI: 1.126, 1.335). PAM and PE exposures were associated with underweight risk in boys and girls, respectively. Moreover, PTFE levels were positively associated with higher BMI z-scores in boys (β = 0.052, 95% CI: 0.003, 0.101). Significant sex-specific associations were observed between exposure to specific MPs and both BMI categories and BMI z-scores in children.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110109"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110105
Ying He , Yang Lyu , Zhenwu Tang
Some exogenous organic pollutants can be accumulated in animals and subsequently be transferred to their offspring. However, the accumulation and maternal transfer characteristics of organic ultraviolet absorbers (OUVAs) in terrestrial species remain poorly understood. This study investigated the accumulation of six OUVAs in domestic hens and their eggs, as well as the subsequent maternal transfer behaviors. Following continuous oral exposure to OUVAs, the average concentration and clearance half-life (33.0 days) of UV-327 were found to be higher than those of the other chemicals in target tissues of hens. The concentration ratios of yolk-liver were 9.19, 5.21, and 5.12 for UV-326, UV-329 and UV-327, respectively, indicating that these chemicals were readily transferred to the eggs. Approximately 56.6%–82.2% of individual OUVAs in the yolk were absorbed by the chicken embryos during incubation, with UV-327 exhibiting the highest absorption rate. In newborn chicks, the three OUVAs, including UV-327, EHMC and 4-MBC, showed significant accumulation in the liver and brain, while the other chemicals primarily accumulated in the muscles. Our findings confirm the strong maternal transfer potential of these OUVAs in domestic hens and highlight concerns about their hram on specific tissues. Given similar habits and feeding ecology, these results also highlight potential implications for wild avian species.
{"title":"Transfer of organic ultraviolet absorbers consumed by laying hens to various tissues in newborn chicks","authors":"Ying He , Yang Lyu , Zhenwu Tang","doi":"10.1016/j.envint.2026.110105","DOIUrl":"10.1016/j.envint.2026.110105","url":null,"abstract":"<div><div>Some exogenous organic pollutants can be accumulated in animals and subsequently be transferred to their offspring. However, the accumulation and maternal transfer characteristics of organic ultraviolet absorbers (OUVAs) in terrestrial species remain poorly understood. This study investigated the accumulation of six OUVAs in domestic hens and their eggs, as well as the subsequent maternal transfer behaviors. Following continuous oral exposure to OUVAs, the average concentration and clearance half-life (33.0 days) of UV-327 were found to be higher than those of the other chemicals in target tissues of hens. The concentration ratios of yolk-liver were 9.19, 5.21, and 5.12 for UV-326, UV-329 and UV-327, respectively, indicating that these chemicals were readily transferred to the eggs. Approximately 56.6%–82.2% of individual OUVAs in the yolk were absorbed by the chicken embryos during incubation, with UV-327 exhibiting the highest absorption rate. In newborn chicks, the three OUVAs, including UV-327, EHMC and 4-MBC, showed significant accumulation in the liver and brain, while the other chemicals primarily accumulated in the muscles. Our findings confirm the strong maternal transfer potential of these OUVAs in domestic hens and highlight concerns about their hram on specific tissues. Given similar habits and feeding ecology, these results also highlight potential implications for wild avian species.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110105"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.envint.2026.110115
Yumeng Yan, Shaopo Wang, Rumeng Wang, Min Ji, Fansheng Meng, Chunsheng Qiu, Lingjie Liu
{"title":"Insight into the role of anthraquinone on the denitrifying phosphorus removal system under perfluorooctanoic acid stress","authors":"Yumeng Yan, Shaopo Wang, Rumeng Wang, Min Ji, Fansheng Meng, Chunsheng Qiu, Lingjie Liu","doi":"10.1016/j.envint.2026.110115","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110115","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.envint.2026.110113
Anran Cai, Lützen Portengen, Virissa Lenters, Sylvie Remy, Yongliang Zhang, Hamid Y. Hassen, Kathryn Dunn, Brismar Pinto-Pacheco, Gerard H. Koppelman, Juliette Legler, Ulrike Gehring, Douglas I. Walker, Roel Vermeulen
{"title":"Metabolic perturbations associated with per- and polyfluoroalkyl substances and their relationships with glycated hemoglobin in the Dutch PIAMA birth cohort","authors":"Anran Cai, Lützen Portengen, Virissa Lenters, Sylvie Remy, Yongliang Zhang, Hamid Y. Hassen, Kathryn Dunn, Brismar Pinto-Pacheco, Gerard H. Koppelman, Juliette Legler, Ulrike Gehring, Douglas I. Walker, Roel Vermeulen","doi":"10.1016/j.envint.2026.110113","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110113","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"43 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1016/j.envint.2026.110112
Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen
{"title":"Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes","authors":"Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen","doi":"10.1016/j.envint.2026.110112","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110112","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"75 1","pages":"110112"},"PeriodicalIF":11.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.envint.2026.110110
Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen
Exposome research and next-generation risk assessment (NGRA) share the goal of improving the human relevance of chemical safety evaluations, yet practical integration remains limited. We developed a flexible framework that combines human biomonitoring (HBM) data, exposome datasets, and exposure modeling results with chemical property, toxicity, and bioactivity information to support NGRA and chemical prioritization. The framework comprises three modules: a curated human exposome database, model-based exposure estimates, and toxicity/bioactivity data integration. Its application was demonstrated in two case studies. Case study 1 focused on organ-specific carcinogens, prioritizing candidate hepatocarcinogens. Case study 2 adopted an exposure-driven approach, highlighting compounds frequently detected in biomonitoring programs across populations. The framework generated quantitative ranges of compound concentrations in biological samples, predicted blood concentrations, and external intake values, which can be compared with in vitro toxicity benchmarks such as half-maximal activity concentration (AC50). Results show that incorporating human exposure data substantially influences chemical prioritization. This framework provides a practical pathway for embedding exposome data into NGRA workflows, thereby strengthening human-relevant risk assessments and informing future chemical safety evaluations.
{"title":"Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing","authors":"Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen","doi":"10.1016/j.envint.2026.110110","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110110","url":null,"abstract":"Exposome research and next-generation risk assessment (NGRA) share the goal of improving the human relevance of chemical safety evaluations, yet practical integration remains limited. We developed a flexible framework that combines human biomonitoring (HBM) data, exposome datasets, and exposure modeling results with chemical property, toxicity, and bioactivity information to support NGRA and chemical prioritization. The framework comprises three modules: a curated human exposome database, model-based exposure estimates, and toxicity/bioactivity data integration. Its application was demonstrated in two case studies. Case study 1 focused on organ-specific carcinogens, prioritizing candidate hepatocarcinogens. Case study 2 adopted an exposure-driven approach, highlighting compounds frequently detected in biomonitoring programs across populations. The framework generated quantitative ranges of compound concentrations in biological samples, predicted blood concentrations, and external intake values, which can be compared with in vitro toxicity benchmarks such as half-maximal activity concentration (AC50). Results show that incorporating human exposure data substantially influences chemical prioritization. This framework provides a practical pathway for embedding exposome data into NGRA workflows, thereby strengthening human-relevant risk assessments and informing future chemical safety evaluations.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"7 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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