Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110109
Hualong Zhen , Changmeng Liu , Dandan Sun , Xinyu Wang , Juan Tong , Guopeng Gao , Xiaoyan Wu , Hong Gan , Shanshan Du , Shuangqin Yan , Fangbiao Tao , Kun Huang
Microplastics (MPs) are widely present in the human world. This study aimed to explore the sex − specific associations between early-life MPs exposure and BMI as well as BMI z-scores in children. We enrolled 1,080 children aged 10 years from the Ma’anshan Birth Cohort in China. A Laser Direct Infrared instrument was used to detect the presence of 19 types of MPs in the children’s urine. Children’s height and weight were measured to calculate BMI and BMI z-scores. Linear regression, logistic regression, restricted cubic spline regression, and Quantile g-computation regression were employed to investigate the associations between the MPs and children’s BMI and BMI z-scores. The results demonstrated the overall detection rate of MPs was 91.1%, with PTFE exhibiting the highest rate at 49.9%. Elevated levels of PE, PAM, and small-size MPs in urine were associated with increased risks of overweight/obesity in boys (OR = 1.156, 95% CI: 1.048, 1.274; OR = 1.278, 95% CI: 1.159, 1.409; OR = 1.114, 95% CI: 1.007, 1.233). PA and PE levels were associated with an increased risk of girls’ overweight/obesity (OR = 1.150, 95% CI: 1.055, 1.252; OR = 1.226, 95% CI: 1.126, 1.335). PAM and PE exposures were associated with underweight risk in boys and girls, respectively. Moreover, PTFE levels were positively associated with higher BMI z-scores in boys (β = 0.052, 95% CI: 0.003, 0.101). Significant sex-specific associations were observed between exposure to specific MPs and both BMI categories and BMI z-scores in children.
{"title":"Sex-specific associations between early-life microplastic exposure and children’s physical development: Evidence from a study in China","authors":"Hualong Zhen , Changmeng Liu , Dandan Sun , Xinyu Wang , Juan Tong , Guopeng Gao , Xiaoyan Wu , Hong Gan , Shanshan Du , Shuangqin Yan , Fangbiao Tao , Kun Huang","doi":"10.1016/j.envint.2026.110109","DOIUrl":"10.1016/j.envint.2026.110109","url":null,"abstract":"<div><div>Microplastics (MPs) are widely present in the human world. This study aimed to explore the sex − specific associations between early-life MPs exposure and BMI as well as BMI z-scores in children. We enrolled 1,080 children aged 10 years from the Ma’anshan Birth Cohort in China. A Laser Direct Infrared instrument was used to detect the presence of 19 types of MPs in the children’s urine. Children’s height and weight were measured to calculate BMI and BMI z-scores. Linear regression, logistic regression, restricted cubic spline regression, and Quantile g-computation regression were employed to investigate the associations between the MPs and children’s BMI and BMI z-scores. The results demonstrated the overall detection rate of MPs was 91.1%, with PTFE exhibiting the highest rate at 49.9%. Elevated levels of PE, PAM, and small-size MPs in urine were associated with increased risks of overweight/obesity in boys (OR = 1.156, 95% CI: 1.048, 1.274; OR = 1.278, 95% CI: 1.159, 1.409; OR = 1.114, 95% CI: 1.007, 1.233). PA and PE levels were associated with an increased risk of girls’ overweight/obesity (OR = 1.150, 95% CI: 1.055, 1.252; OR = 1.226, 95% CI: 1.126, 1.335). PAM and PE exposures were associated with underweight risk in boys and girls, respectively. Moreover, PTFE levels were positively associated with higher BMI z-scores in boys (β = 0.052, 95% CI: 0.003, 0.101). Significant sex-specific associations were observed between exposure to specific MPs and both BMI categories and BMI z-scores in children.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110109"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.envint.2026.110105
Ying He , Yang Lyu , Zhenwu Tang
Some exogenous organic pollutants can be accumulated in animals and subsequently be transferred to their offspring. However, the accumulation and maternal transfer characteristics of organic ultraviolet absorbers (OUVAs) in terrestrial species remain poorly understood. This study investigated the accumulation of six OUVAs in domestic hens and their eggs, as well as the subsequent maternal transfer behaviors. Following continuous oral exposure to OUVAs, the average concentration and clearance half-life (33.0 days) of UV-327 were found to be higher than those of the other chemicals in target tissues of hens. The concentration ratios of yolk-liver were 9.19, 5.21, and 5.12 for UV-326, UV-329 and UV-327, respectively, indicating that these chemicals were readily transferred to the eggs. Approximately 56.6%–82.2% of individual OUVAs in the yolk were absorbed by the chicken embryos during incubation, with UV-327 exhibiting the highest absorption rate. In newborn chicks, the three OUVAs, including UV-327, EHMC and 4-MBC, showed significant accumulation in the liver and brain, while the other chemicals primarily accumulated in the muscles. Our findings confirm the strong maternal transfer potential of these OUVAs in domestic hens and highlight concerns about their hram on specific tissues. Given similar habits and feeding ecology, these results also highlight potential implications for wild avian species.
{"title":"Transfer of organic ultraviolet absorbers consumed by laying hens to various tissues in newborn chicks","authors":"Ying He , Yang Lyu , Zhenwu Tang","doi":"10.1016/j.envint.2026.110105","DOIUrl":"10.1016/j.envint.2026.110105","url":null,"abstract":"<div><div>Some exogenous organic pollutants can be accumulated in animals and subsequently be transferred to their offspring. However, the accumulation and maternal transfer characteristics of organic ultraviolet absorbers (OUVAs) in terrestrial species remain poorly understood. This study investigated the accumulation of six OUVAs in domestic hens and their eggs, as well as the subsequent maternal transfer behaviors. Following continuous oral exposure to OUVAs, the average concentration and clearance half-life (33.0 days) of UV-327 were found to be higher than those of the other chemicals in target tissues of hens. The concentration ratios of yolk-liver were 9.19, 5.21, and 5.12 for UV-326, UV-329 and UV-327, respectively, indicating that these chemicals were readily transferred to the eggs. Approximately 56.6%–82.2% of individual OUVAs in the yolk were absorbed by the chicken embryos during incubation, with UV-327 exhibiting the highest absorption rate. In newborn chicks, the three OUVAs, including UV-327, EHMC and 4-MBC, showed significant accumulation in the liver and brain, while the other chemicals primarily accumulated in the muscles. Our findings confirm the strong maternal transfer potential of these OUVAs in domestic hens and highlight concerns about their hram on specific tissues. Given similar habits and feeding ecology, these results also highlight potential implications for wild avian species.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"208 ","pages":"Article 110105"},"PeriodicalIF":9.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.envint.2026.110115
Yumeng Yan, Shaopo Wang, Rumeng Wang, Min Ji, Fansheng Meng, Chunsheng Qiu, Lingjie Liu
{"title":"Insight into the role of anthraquinone on the denitrifying phosphorus removal system under perfluorooctanoic acid stress","authors":"Yumeng Yan, Shaopo Wang, Rumeng Wang, Min Ji, Fansheng Meng, Chunsheng Qiu, Lingjie Liu","doi":"10.1016/j.envint.2026.110115","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110115","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"34 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.envint.2026.110113
Anran Cai, Lützen Portengen, Virissa Lenters, Sylvie Remy, Yongliang Zhang, Hamid Y. Hassen, Kathryn Dunn, Brismar Pinto-Pacheco, Gerard H. Koppelman, Juliette Legler, Ulrike Gehring, Douglas I. Walker, Roel Vermeulen
{"title":"Metabolic perturbations associated with per- and polyfluoroalkyl substances and their relationships with glycated hemoglobin in the Dutch PIAMA birth cohort","authors":"Anran Cai, Lützen Portengen, Virissa Lenters, Sylvie Remy, Yongliang Zhang, Hamid Y. Hassen, Kathryn Dunn, Brismar Pinto-Pacheco, Gerard H. Koppelman, Juliette Legler, Ulrike Gehring, Douglas I. Walker, Roel Vermeulen","doi":"10.1016/j.envint.2026.110113","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110113","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"43 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1016/j.envint.2026.110112
Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen
{"title":"Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes","authors":"Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen","doi":"10.1016/j.envint.2026.110112","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110112","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"75 1","pages":"110112"},"PeriodicalIF":11.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.envint.2026.110110
Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen
Exposome research and next-generation risk assessment (NGRA) share the goal of improving the human relevance of chemical safety evaluations, yet practical integration remains limited. We developed a flexible framework that combines human biomonitoring (HBM) data, exposome datasets, and exposure modeling results with chemical property, toxicity, and bioactivity information to support NGRA and chemical prioritization. The framework comprises three modules: a curated human exposome database, model-based exposure estimates, and toxicity/bioactivity data integration. Its application was demonstrated in two case studies. Case study 1 focused on organ-specific carcinogens, prioritizing candidate hepatocarcinogens. Case study 2 adopted an exposure-driven approach, highlighting compounds frequently detected in biomonitoring programs across populations. The framework generated quantitative ranges of compound concentrations in biological samples, predicted blood concentrations, and external intake values, which can be compared with in vitro toxicity benchmarks such as half-maximal activity concentration (AC50). Results show that incorporating human exposure data substantially influences chemical prioritization. This framework provides a practical pathway for embedding exposome data into NGRA workflows, thereby strengthening human-relevant risk assessments and informing future chemical safety evaluations.
{"title":"Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing","authors":"Yifeng Dai, Bob van de Water, Jaione Telleria, Laura I. Furlong, Roel C.H. Vermeulen, Jelle Vlaanderen","doi":"10.1016/j.envint.2026.110110","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110110","url":null,"abstract":"Exposome research and next-generation risk assessment (NGRA) share the goal of improving the human relevance of chemical safety evaluations, yet practical integration remains limited. We developed a flexible framework that combines human biomonitoring (HBM) data, exposome datasets, and exposure modeling results with chemical property, toxicity, and bioactivity information to support NGRA and chemical prioritization. The framework comprises three modules: a curated human exposome database, model-based exposure estimates, and toxicity/bioactivity data integration. Its application was demonstrated in two case studies. Case study 1 focused on organ-specific carcinogens, prioritizing candidate hepatocarcinogens. Case study 2 adopted an exposure-driven approach, highlighting compounds frequently detected in biomonitoring programs across populations. The framework generated quantitative ranges of compound concentrations in biological samples, predicted blood concentrations, and external intake values, which can be compared with in vitro toxicity benchmarks such as half-maximal activity concentration (AC50). Results show that incorporating human exposure data substantially influences chemical prioritization. This framework provides a practical pathway for embedding exposome data into NGRA workflows, thereby strengthening human-relevant risk assessments and informing future chemical safety evaluations.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"7 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-25DOI: 10.1016/j.envint.2026.110107
Mongju Jeong, Goeun Jung, Won Kyung Kim, Woo Jin Kim, Sun-Young Kim
To address the unavailability of air pollution measurements for individuals, epidemiological studies have estimated air pollution at people’s residences or workplaces using exposure prediction models consisting of numerous geographic characteristics. However, these characteristics that represent potential pollution sources are typically fixed in time, ignoring temporal changes. Such ignorance may affect the accuracy of exposure prediction and the validity in health analyses. This study compared the predictive performance of time-aligned models (TAM) including temporally-varying geographic characteristics with time-constant models (TCM) comprised of fixed-year characteristics over 20 years for 2001–2019 in South Korea. Using regulatory air quality monitoring data from 136 to 422 sites, we computed annual-average concentrations of particulate matter ≤ 10 and 2.5 μm per diameter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone. We also computed about 300 geographic variables for 2001, 2005, 2010, and 2015. Then, we developed two types of prediction models in universal kriging including a few predictors estimated by partial least squares regression from geographic variables constructed in four years (TAM) and in 2010 only (TCM). TAM showed generally higher cross-validation (CV) R2s than TCM across all four pollutants. The outperformance of TAM was notable with 3–15 higher percentage points (TCM and TAM CV R2: 0.45 and 0.48 for PM2.5; 0.35 and 0.50 for PM10) in long-term average predictions. Moreover, predictions at residential locations gave higher accuracy with ∼ 52 percentage points higher R2s in TAM (CV R2: 0.52) than TCM (0.00), when evaluated using measurements at the nearest regulatory monitoring sites. Our findings suggest the significant role of temporal changes of geographic characteristics in estimating long-term exposure to air pollution of individuals for epidemiological studies.
{"title":"Changes in environments over 20 years and the assessment of individual long-term exposure to air pollution for epidemiology","authors":"Mongju Jeong, Goeun Jung, Won Kyung Kim, Woo Jin Kim, Sun-Young Kim","doi":"10.1016/j.envint.2026.110107","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110107","url":null,"abstract":"To address the unavailability of air pollution measurements for individuals, epidemiological studies have estimated air pollution at people’s residences or workplaces using exposure prediction models consisting of numerous geographic characteristics. However, these characteristics that represent potential pollution sources are typically fixed in time, ignoring temporal changes. Such ignorance may affect the accuracy of exposure prediction and the validity in health analyses. This study compared the predictive performance of time-aligned models (TAM) including temporally-varying geographic characteristics with time-constant models (TCM) comprised of fixed-year characteristics over 20 years for 2001–2019 in South Korea. Using regulatory air quality monitoring data from 136 to 422 sites, we computed annual-average concentrations of particulate matter ≤ 10 and 2.5 μm per diameter (PM<ce:inf loc=\"post\">10</ce:inf> and PM<ce:inf loc=\"post\">2.5</ce:inf>), nitrogen dioxide (NO<ce:inf loc=\"post\">2</ce:inf>), and ozone. We also computed about 300 geographic variables for 2001, 2005, 2010, and 2015. Then, we developed two types of prediction models in universal kriging including a few predictors estimated by partial least squares regression from geographic variables constructed in four years (TAM) and in 2010 only (TCM). TAM showed generally higher cross-validation (CV) R<ce:sup loc=\"post\">2</ce:sup>s than TCM across all four pollutants. The outperformance of TAM was notable with 3–15 higher percentage points (TCM and TAM CV R<ce:sup loc=\"post\">2</ce:sup>: 0.45 and 0.48 for PM<ce:inf loc=\"post\">2.5</ce:inf>; 0.35 and 0.50 for PM<ce:inf loc=\"post\">10</ce:inf>) in long-term average predictions. Moreover, predictions at residential locations gave higher accuracy with ∼ 52 percentage points higher R<ce:sup loc=\"post\">2</ce:sup>s in TAM (CV R<ce:sup loc=\"post\">2</ce:sup>: 0.52) than TCM (0.00), when evaluated using measurements at the nearest regulatory monitoring sites. Our findings suggest the significant role of temporal changes of geographic characteristics in estimating long-term exposure to air pollution of individuals for epidemiological studies.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"291 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The administrative boundaries of Shanghai in the original Figs. 1 and 2 are incorrect because the Chinese map file we previously used did not have a very high resolution, resulting in some distortion of the administrative boundaries in the coastal areas. We have updated the boundaries of Shanghai.
{"title":"Corrigendum to “Multiscale risks-bioaccessibility coupling framework for improving derivation of soil cadmium threshold”. [Environ. Int. 207 (2026) 110036]","authors":"Shiyan Yang, Qianhang Zhou, Lijuan Sun, Qin Qin, Yafei Sun, Jun Wang, Xingmei Liu, Zhangtao Li, Yong Xue","doi":"10.1016/j.envint.2026.110081","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110081","url":null,"abstract":"The administrative boundaries of Shanghai in the original Figs. 1 and 2 are incorrect because the Chinese map file we previously used did not have a very high resolution, resulting in some distortion of the administrative boundaries in the coastal areas. We have updated the boundaries of Shanghai.<span><figure><span><img alt=\"\" height=\"356\" src=\"https://ars.els-cdn.com/content/image/1-s2.0-S0160412026000395-fx1.jpg\"/><ol><li><span><span>Download: <span>Download high-res image (312KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"44 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.envint.2026.110103
Jingqi Liu, Jiaming Wu, Xinwen Huang, Dan Yu, Zhuo Huang, Hongbo Chen, Chuan Wang, Tian Tang, Falin He
The risks and attributable burden of adverse birth outcomes from flooding remain unclear. Here, we analyzed a nationwide cohort of over 4.4 million mother-infant pairs in China, matching a spatiotemporal flood database with multiple buffer zones centered on maternal delivery hospitals to assess the health risks of multi-window flood exposure before and during pregnancy. We found that flood exposure during the three months preconception and the first trimester significantly increased the risks of preterm birth (PTB), low birth weight (LBW), small for gestational age (SGA), and term low birth weight (TLBW). Based on exposure assessment within a 3000-meter buffer, we estimate that between 2013 and 2019, first-trimester flood exposure accounted for 925,717 attributable cases of PTB (95% Uncertainty Interval [UI]: 814,446–1,035,426), with an attributable fraction (AF) of 13.56%; 418,333 cases of LBW (95% UI: 359,916–475,711; AF, 13.47%); 263,977 cases of SGA (95% UI: 101,700–424,152; AF, 2.81%); and 591,283 cases of TLBW (95% UI: 364,246–810,774; AF, 9.23%). This study quantifies a major perinatal health burden from flooding and identifies critical windows for intervention before and during early pregnancy.
洪水造成的不良生育结果的风险和可归因负担仍不清楚。在这里，我们分析了中国超过440万对母婴的全国队列，将一个时空洪水数据库与以产妇分娩医院为中心的多个缓冲区相匹配，以评估怀孕前和怀孕期间多窗口洪水暴露的健康风险。我们发现，在孕前3个月和孕早期接触洪水显著增加了早产（PTB）、低出生体重（LBW）、小胎龄（SGA）和足月低出生体重（TLBW）的风险。基于3000米缓冲区内的暴露评估，我们估计在2013年至2019年期间，孕早期洪水暴露占925,717例PTB归因病例（95%不确定区间[UI]: 814,446-1,035,426），归因分数（AF）为13.56%；LBW 418,333例（95% UI: 359,916-475,711; AF 13.47%）；SGA 263977例（95% UI: 101700 ~ 424152例；AF 2.81%）；TLBW 591,283例（95% UI: 364,246 ~ 810,774; AF 9.23%）。本研究量化了洪水造成的主要围产期健康负担，并确定了孕前和妊娠早期干预的关键窗口。
{"title":"Risk and burden of adverse birth outcomes associated with flood exposure in China: A 4.4 million mother-infant cohort study","authors":"Jingqi Liu, Jiaming Wu, Xinwen Huang, Dan Yu, Zhuo Huang, Hongbo Chen, Chuan Wang, Tian Tang, Falin He","doi":"10.1016/j.envint.2026.110103","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110103","url":null,"abstract":"The risks and attributable burden of adverse birth outcomes from flooding remain unclear. Here, we analyzed a nationwide cohort of over 4.4 million mother-infant pairs in China, matching a spatiotemporal flood database with multiple buffer zones centered on maternal delivery hospitals to assess the health risks of multi-window flood exposure before and during pregnancy. We found that flood exposure during the three months preconception and the first trimester significantly increased the risks of preterm birth (PTB), low birth weight (LBW), small for gestational age (SGA), and term low birth weight (TLBW). Based on exposure assessment within a 3000-meter buffer, we estimate that between 2013 and 2019, first-trimester flood exposure accounted for 925,717 attributable cases of PTB (95% Uncertainty Interval [UI]: 814,446–1,035,426), with an attributable fraction (AF) of 13.56%; 418,333 cases of LBW (95% UI: 359,916–475,711; AF, 13.47%); 263,977 cases of SGA (95% UI: 101,700–424,152; AF, 2.81%); and 591,283 cases of TLBW (95% UI: 364,246–810,774; AF, 9.23%). This study quantifies a major perinatal health burden from flooding and identifies critical windows for intervention before and during early pregnancy.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"1 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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