Environment International最新文献

{"title":"Characterizing adaptive capacity for the future heat-related cardiovascular morbidity burden in U.S. Metropolitan areas","authors":"Wei-Lun Tsai ,&nbsp;E.Melissa Mcinroe ,&nbsp;Anna M. Jalowska ,&nbsp;Corinna Y. Keeler ,&nbsp;Stephanie E. Cleland ,&nbsp;Cassandra R. O’Lenick ,&nbsp;Tanya L. Spero ,&nbsp;Alexandra Schneider ,&nbsp;Ana G. Rappold","doi":"10.1016/j.envint.2025.110022","DOIUrl":"10.1016/j.envint.2025.110022","url":null,"abstract":"<div><div>Exposure to excess heat is linked to increased risks of cardiovascular diseases (CVD). As temperatures increase globally, it is crucial to examine the potential increase in excess heat-related CVD (xHEAT-CVD) burden to inform strategies for adaptation. This study aimed to identify the contextual factors associated with future xHEAT-CVD burden among older adults across eighty U.S. metropolitan statistical areas (MSAs).</div><div>The MSA-specific xHEAT-CVD risk for adults ≥ 65 years was estimated using hospitalization and temperature data from 2000 to 2017, with excess heat defined as temperatures above the minimum hospitalization percentile (T_MHP). Future xHEAT-CVD hospitalizations were estimated using temperature projections for 2025–2054, 2045–2074, and 2070–2099 under three climate scenarios. Area-level variables were used to identify demographic and economic status, health, environment, and infrastructure contexts and derive Urban Heat Health Risk (UHHR) scores using confirmatory factor analysis. The associations between adaptive capacity (the UHHR scores) and future xHEAT-CVD burden were examined.</div><div>In 2070–2099 under the mildest scenario, 36 more days annually were projected to be ≥ T_MHP, and xHEAT-CVD burden was projected to increase by at least 20.4-fold. Lower adaptive capacity was associated with greater increases in future xHEAT-CVD burden, over 9-fold increase per 1-unit increase in UHHR score (9.1, 95 % Confidence Intervals: 2.8–15.4). The historical xHEAT-CVD burden (2000–2017) was largely driven by the health context, whereas environment played a more important role in the future.</div><div>Our findings suggest that drivers of the xHEAT-CVD burden may vary across time. Targeting the areas with the highest xHEAT-CVD burden at varying timeframes can help mitigate xHEAT-CVD burden more effectively.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110022"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological filtering enhanced by smaller PBS biodegradable microplastics constrains ARG dynamics in the soil plastisphere","authors":"Congxun Huang ,&nbsp;Pan Huang ,&nbsp;Yi Zhang ,&nbsp;Mark Bartlam ,&nbsp;Yingying Wang","doi":"10.1016/j.envint.2025.110030","DOIUrl":"10.1016/j.envint.2025.110030","url":null,"abstract":"<div><div>Microplastics (MPs) are increasingly recognized as hotspots for antibiotic resistance genes (ARGs), yet the combined effects of polymer type and particle size on ARG dynamics in the soil plastisphere remain unclear. Here, we employed metagenomic assembly and binning to explore how MP polymer type and particle size jointly modulate ARG carrying frequencies (ACFs), mobility, and microbial hosts with polyethylene (PE), polystyrene (PS), and biodegradable polybutylene succinate (PBS) MPs across a size gradient (1000, 500, and 106 μm). PBS, PS, and PE plastispheres exhibited different size-related trends in ARG association, with PBS showing the strongest and most consistent decline in ACFs. Only PBS showed a corresponding reduction in ARG–MGE co-localization, suggesting size-dependent constraints on horizontal gene transfer. Distinct ARG combinations in ARG-Carrying Contigs (ACCs) also showed plastic-type selectivity, with complex resistance clusters absent in 106 μm PBS samples, potentially due to environmental constraints that limit the assembly or persistence of multigene resistance structures. Potential pathogens <em>Enterobacter bugandensis</em> and <em>Stutzerimonas urumqiensis</em> were markedly reduced in 106 μm PBS samples, a pattern not observed in PS or PE. Bacterial community analysis revealed that smaller PBS particles were associated with reduced richness, increased evenness, and more competitive interactions within co-occurrence networks. These features, together with the decline in ARG abundance and mobility, suggest that enhanced ecological filtering may occur in smaller biodegradable plastispheres, jointly limiting the persistence of resistance genes and their bacterial hosts. Together, our findings highlight the importance of considering both MP type and particle size in assessing plastisphere-associated ARG risks.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110030"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145895256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Priority control strategies derived from updated measurement of VOCs source profiles for plastic product industry","authors":"Xiuying Zhao ,&nbsp;Wutao Zeng ,&nbsp;Chenghao Liao ,&nbsp;Hao Han ,&nbsp;Minhui Li ,&nbsp;Zhiyang Liu ,&nbsp;Yongbo Zhang","doi":"10.1016/j.envint.2025.110019","DOIUrl":"10.1016/j.envint.2025.110019","url":null,"abstract":"<div><div>To address the lack of localized volatile organic compounds (VOCs) source profiles in the plastic products industry, this study measured VOCs emissions from 17 representative manufacturers in Guangdong Province, the leading plastic producer in China. A total of 114 VOCs species were identified, and source profiles for 10 production processes were established. Oxygenated volatile organic compounds (OVOCs), aromatics, and alkanes were the predominant species across various manufacturing stages. Molding and post-processing were identified as the main emission processes: OVOCs, aromatics and alkanes were dominant in molding, whereas OVOCs and aromatics were more prevalent in post-processing. The Ozone formation potential (OFP) was calculated to identify priority control species. OFP values ranged from 0.39 to 17.03 mg/m³, identifying isopropanol, toluene, and hexanal as key control species. Furthermore, emission factors were updated based on product type. This study established the first comprehensive VOC source profiles and process-specific emission factors for the plastic industry in Guangdong, providing a scientific basis for targeted emission management and pollution control strategies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110019"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from an invited expert panel using a World Café: Developing a national policy for a human biomonitoring programme","authors":"Richa Singh ,&nbsp;Sewon Lee ,&nbsp;Darragh Doherty ,&nbsp;Conor Buggy ,&nbsp;Holger Martin Koch ,&nbsp;Marike Kolossa-Gehring ,&nbsp;Alison Connolly","doi":"10.1016/j.envint.2025.110025","DOIUrl":"10.1016/j.envint.2025.110025","url":null,"abstract":"<div><div>Human biomonitoring (HBM) is a powerful tool for quantifying internal chemical levels via biological samples such as blood and urine. Between 2000 and 2017, global synthetic chemical production doubled from approximately 1.15 billion tonnes to 2.3 billion tonnes, with this trend continuing to increase. There has been an extensive expansion of national HBM programmes to evaluate actual chemical exposures and safeguard their citizens.</div><div>A key factor in the development of HBM is to include policymakers and to utilise HBM data for policy impact. This study, part of the HBM4IRE (Human Biomonitoring for Ireland) feasibility study, employed a World Café approach for engaging 25 stakeholders from government agencies, industry, and academia to co-create a national HBM roadmap. Using a critical realist approach and thematic analysis of qualitative data, four key themes emerged from the discussion: (1) targeted HBM for exposure hotspots, (2) mapping HBM to EU and National policy frameworks, (3) monitoring chemical exposures as an early warning system, and (4) aligning HBM with national legislative needs.</div><div>Results highlight HBM’s critical role in identifying at-risk groups (such as workers in high-exposure industries, children exposed to recycled materials like playground tyres) and validating policy effectiveness (e.g., lead restriction impacts). It also highlighted challenges such as data gaps, high costs, and limited baseline information. Study participants expressed a need for a governance framework, including a national HBM Steering Committee and inter-institutional collaboration, to bridge science-to-policy gaps, offering a scalable model for other nations to enhance chemical risk management, ensure regulatory compliance, and strengthen public health protection.</div><div>Overall, stakeholders expressed a high interest and strong willingness in establishing a national HBM programme in Ireland, viewing this as an opportune time for Ireland to implement such a system. The approach adopted for this study could be utilised to engage different stakeholders across an array of relevant topics. Given its valuable outcomes, the HBM4IRE World Café approach has demonstrated that it can serve as a model for other countries to build consensus, identify gaps, and foster stakeholder ownership in establishing long-term and sustainable national HBM programmes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110025"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated network toxicology and molecular docking are used to elucidate the mechanism by which chlorpyrifos induces hepatotoxicity (Cyprinus carpio)","authors":"Xiaojing Li ,&nbsp;Huanqi Zhang ,&nbsp;Peizhong Yu ,&nbsp;Xiaozhe Chen ,&nbsp;Yuhong Yang ,&nbsp;Shiwen Xu","doi":"10.1016/j.envint.2025.110032","DOIUrl":"10.1016/j.envint.2025.110032","url":null,"abstract":"<div><div>Chlorpyrifos (CPF), a typical organophosphorus pesticide, is frequently applied for pest control in households and agriculture worldwide. Liver, being the primary site for xenobiotic metabolism, is extremely vulnerable to drug threats. To elucidate the hepatotoxic mechanism of CPF and identify targets for its relief, the overlapping data between CPF-associated targets and liver injury-related genes were analyzed. It was found that CPF hepatotoxicity targets were mainly involved in oxidoreductase activity, fatty acid metabolism, glutathione metabolic process, response to biotic stimulus, ferroptosis, and mitochondrion disorders. TP53 molecular exhibited the strong binding stability with CPF, and TP53-mediated SLC7A11/GPX4 signaling suppression contributed to CPF-induced hepatotoxicity in <em>Cyprinus carpio</em>. CPF disrupted iron homeostasis by downregulating FTH, NCOA4, and FPN expressions, while simultaneously increasing ACSL4 expression to promote the accumulation of lipid peroxides MDA and LPO. Meanwhile, CPF reduced intracellular GPX4 levels, thereby diminishing lipid ROS scavenging capacity and triggering ferroptosis. Selenium (Se) could reverse CPF- and Erastin-induced ferroptosis and mitochondrial dysfunction. GSH depletion and GPX4 silencing reversed the alleviating effect of Se on CPF-induced lipid peroxidation, but they had little effect on iron contents. Meanwhile, Se addition also increased GSH contents and GPX4 protein expressions. The results revealed some targets of CPF-induced hepatotoxicity. These studies provided the theoretical basis for the future development of environmental monitoring and pollutant control strategies.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110032"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compounding hazards posed by wildfires, flooding, and resource extraction: Assessing multimedia metal(loid) exposures and risk in rural, southwestern U.S. Populations","authors":"Zain Alabdain Alqattan ,&nbsp;God’sgift N. Chukwuonye ,&nbsp;Camille Tinerella ,&nbsp;Miriam Jones ,&nbsp;Mónica D. Ramírez-Andreotta","doi":"10.1016/j.envint.2025.110034","DOIUrl":"10.1016/j.envint.2025.110034","url":null,"abstract":"<div><div>Understanding the extent of contamination due to climatic events in rural areas is necessary to protect environmental health, especially when these spaces disproportionately bear the burden of resource extraction. Using a Monte Carlo-based probabilistic assessment, this study investigates how wildfire and subsequent flooding influences As, Cd, Cu, Cr, Pb, Mn, Ni, and Zn exposure from non-residential sediment and residential soil and indoor/outdoor dust. Carcinogenic/cumulative target cancer risk (TCR) and noncarcinogenic/cumulative hazard index (HI) were evaluated across multiple exposure pathways and scenarios (residential, nonresidential) for children and adults in rural, Arizona communities. In residential settings, flooding significantly increased (p ≤ 0.05) Pb and Cu surface soil concentrations. In both populations, HI_flooded &gt; 1, while TCR_flooded falls within the tolerable U.S.EPA risk threshold. The mean HI_t-Child &gt; 1 was driven by As, Cu, and Mn in outdoor dust followed by Pb and Zn in soil. Arsenic incidental ingestion and to a lesser degree Pb from residential outdoor dust was the prominent exposure pathway, leading to 1.6 cancer cases for every 10,000 children, whereas an adult’s exposure/associated risk was dominated by soil. Outdoor dust led to an unacceptable carcinogenic risk for children and cleanup efforts are imperative. Children growing up in rural, southwestern resource extraction communities experiencing climate extremes are bearing the burden, facing increased health risks. When navigating climatic challenges in rural, resource extraction regions, community-centered environmental research translation and nature-based solutions are critical to mitigating environmental exposures and associated health risks.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110034"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a mother–child dyad toxicokinetic model paired with environmental doses for estimation of serum per- and polyfluoroalkyl substances in early life","authors":"Yerin Jung ,&nbsp;Marc-André Verner ,&nbsp;Scott M. Bartell","doi":"10.1016/j.envint.2026.110046","DOIUrl":"10.1016/j.envint.2026.110046","url":null,"abstract":"<div><div>Contact-based exposure estimation paired with empirically evaluated toxicokinetic (TK) modeling can complement direct measurements of serum concentrations for characterizing individual exposures and provide a proxy for risk assessment. This study examined whether a mother–child dyad TK model paired with PFAS exposure estimates provide reasonable predictions of serum PFAS concentrations for children. A previously published mother–child dyad TK model was used to estimate the child serum concentrations. We modified the model by updating with recent TK parameter estimates. Background intake rates via food, indoor dust, and indoor air were from published studies. Estimation of child serum PFOA concentrations in PFOA-contaminated regions additionally considered exposure to contaminated drinking water and outdoor air. TK-modeled serum concentrations were then compared with measured serum concentrations from child cohorts for four PFAS (PFOA, PFOS, PFHxS, and PFNA) from other published studies. Individual serum PFOA measurements from the C8 Health Study were compared with modeled serum concentrations using the modified and other published TK models. Modeled child PFAS serum concentrations using the modified dyad TK model were in good accordance with measured serum concentrations. The median model predictions of serum PFOA were highly correlated with the median of measured values and the percentage of TK-modeled serum PFOA within 2-fold and 10-fold of measured values was 34% and 94%, respectively, which was similar or higher than the estimates from the other TK models. The modified dyad TK model can provide reasonable estimates of dynamic serum PFAS concentrations for children when only environmental doses are available.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110046"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating nontargeted metabolomics and machine learning to assess PFAS exposure associations with liver cancer risk","authors":"Tong Wu ,&nbsp;Jiamian Fang ,&nbsp;Jiawei Hong ,&nbsp;Yifan Jiang ,&nbsp;Keyi Du ,&nbsp;Weichen Zhang ,&nbsp;Siqi Zhang ,&nbsp;Tingting Pan ,&nbsp;Liyun Fu ,&nbsp;Weili Mao ,&nbsp;Hangbiao Jin ,&nbsp;Wendi Hu ,&nbsp;Shusen Zheng ,&nbsp;Linping Cao","doi":"10.1016/j.envint.2025.110014","DOIUrl":"10.1016/j.envint.2025.110014","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFASs) are persistent synthetic chemicals, showing global presence in environment and human populations. Despite accumulating evidence implicating PFASs in liver toxicity, epidemiological data linking PFAS exposure to liver cancer risk remain limited, particularly regarding the underlying molecular mechanisms in humans. In this case-control study, we quantified concentrations of nine PFASs and performed nontargeted metabolomics in serum samples from 116 newly diagnosed liver cancer cases and 400 matched controls. Advanced supervised machine learning models were employed to identify PFAS exposure-associated metabolic features, followed by pathway enrichment and mediation analyses to elucidate biological mechanisms. Higher human serum levels of perfluorooctanoic acid (PFOA), perfluorononanoate, perfluorodecanoate, perfluorohexane sulfonate, perfluorooctanesulfonic acid, and 6:2 chlorinated polyfluoroether sulfonic acid were significantly correlated with the increased liver cancer risk. Weighted quantile sum index for the PFAS mixture was significantly correlated with an elevated liver cancer risk, with PFOA identified as the dominant contributor to this association. Least absolute shrinkage and selection operator (LASSO) approach based on metabolomic variables achieved the greatest predictive accuracy. Disruptions in methionine metabolism and phospholipid biosynthesis were identified as significant mediators in the association between serum PFAS levels and liver cancer risk, as revealed by LASSO modeling and mediation analyses. To our awareness, this study first demonstrates that multiple PFAS exposure may promote liver carcinogenesis through perturbations in amino acid and membrane lipid metabolism in humans.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110014"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145785412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-lung axis: a novel mechanism involving microbiota dysbiosis-coordinated PLA2-TRPV1 neuroimmune crosstalk in nanoplastic-induced asthma exacerbation","authors":"Xin Zeng ,&nbsp;Chuhao He ,&nbsp;Jitong Li ,&nbsp;Qing Feng ,&nbsp;Zhenjie Lu ,&nbsp;Long Li ,&nbsp;Yongkang Qiao ,&nbsp;Wei Han ,&nbsp;Faming Wang ,&nbsp;Mingqing Chen ,&nbsp;Chan Lu ,&nbsp;Rong She ,&nbsp;Yang Wu ,&nbsp;Yanling Sun ,&nbsp;Xu Yang ,&nbsp;Ping Ma ,&nbsp;Surui Lu","doi":"10.1016/j.envint.2026.110047","DOIUrl":"10.1016/j.envint.2026.110047","url":null,"abstract":"<div><div>This study, based on an OVA-sensitized mouse model, systematically elucidates the molecular mechanisms through which 20 nm polystyrene nanoplastics (PS-NPs) exacerbate asthma. A series of assessments were conducted, including measurements of airway hyperresponsiveness (AHR), histopathological analysis of lung tissue using HE, PAS and Masson staining, immunohistochemical detection of phospholipase A2 (PLA2) and TRPV1 expression, quantification of serum immunoglobulins and tissue cytokines, as well as lung metabolomics and gut microbiota profiling. Exposure to PS-NPs activated PLA2 in lung tissue, leading to the accumulation of arachidonic acid metabolites such as prostaglandin E2 and leukotriene B4. This process increased TRPV1 channel expression and promoted the release of neuropeptides including substance P and calcitonin gene-related peptide. The resulting cascade activated the NF-κB signaling pathway, thereby enhancing Th2-type inflammatory responses characterized by elevated IL-4, IL-5 and IL-13, reduced IFN-γ, and increased oxidative stress markers such as 8-OHdG. PS-NPs also significantly altered the gut microbiota, increasing the abundance of Pseudomonadota, Actinomycetota and Verrucomicrobiota. Gram-negative bacteria released substantial amounts of <em>hexa</em>-acylated LPS, which activated the intestinal TLR4/NF-κB pathway and promoted pulmonary inflammation through the gut–lung axis. Furthermore, dysbiosis-induced reductions in short-chain fatty acid production and abnormalities in glycerophospholipid and amino acid metabolism further enhanced pulmonary PLA2 activity, forming a PLA2–TRPV1–neuroimmune positive feedback loop that aggravated airway hyperresponsiveness and lung tissue damage. Overall, this study suggests the central role of a metabolism–immune–neuroinflammatory network mediated by the gut–lung axis in asthma aggravated by PS-NPs, providing new insights into the respiratory toxicity of environmental nanoplastics.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110047"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of heat strain and air pollution on kidney health","authors":"Jaime Butler-Dawson ,&nbsp;Diana Jaramillo ,&nbsp;Lyndsay Krisher ,&nbsp;Karely Villarreal Hernandez ,&nbsp;Laura Calvimontes ,&nbsp;Grant Erlandson ,&nbsp;James Seidel ,&nbsp;Colton Castro ,&nbsp;Stephen Brindley ,&nbsp;Yaqiang Li ,&nbsp;Miranda Dally ,&nbsp;Katherine A. James ,&nbsp;Richard J. Johnson ,&nbsp;Daniel Pilloni ,&nbsp;Alex Cruz ,&nbsp;Nicholas Smith ,&nbsp;Evan Johnson ,&nbsp;Joshua W. Schaeffer ,&nbsp;John L. Adgate ,&nbsp;Lee S. Newman","doi":"10.1016/j.envint.2025.110042","DOIUrl":"10.1016/j.envint.2025.110042","url":null,"abstract":"<div><h3>Background</h3><div>Rising global temperatures raise concerns about climate change’s health impacts. Agricultural workers are particularly vulnerable due to prolonged exposure to heat and environmental pollutants, including airborne particulate matter (PM), which may increase their risk for kidney injury. This study explores the relationships between core body temperature (CBT), markers of hydration, PM exposure, and kidney injury, offering insights into public health risks related to climate change.</div></div><div><h3>Methods</h3><div>We conducted a longitudinal study of 148 sugarcane workers in Guatemala, monitoring them over 378 person-workdays. CBT and personal PM exposure were recorded throughout the workday, while markers of hydration and kidney function were assessed pre- and post-shift. Linear mixed-effects models were used to assess the relationships between these exposure factors, dehydration markers, and serum creatinine changes, an indicator of kidney injury.</div></div><div><h3>Findings</h3><div>CBT exceeded 38.0 °C on 53 % of workdays, with 15 % surpassing 38.5 °C. Higher urinary specific gravity (β: 3.82, 95 % CI: 0.84, 6.80), serum uric acid (β: 2.46, 95 % CI: 0.70, 2.14), average heat index (β: 1.33, 95 % CI: 0.53, 2.14), and CBT exceeding 38.5 °C (β: 8.95, 95 % CI: 2.89, 15.02) were significantly associated with cross-shift increases in serum creatinine. Despite substantial PM₅ exposure, no significant association with creatinine changes was found.</div></div><div><h3>Conclusions</h3><div>Heat strain and dehydration are significant contributors to kidney injury in agricultural workers, highlighting critical public health risks. These findings emphasize the urgent need for interventions to mitigate heat-related health hazards, including workplace protections, hydration strategies, and climate adaptation policies to safeguard vulnerable populations worldwide.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"207 ","pages":"Article 110042"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}