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Polycyclic aromatic hydrocarbons and cannabinoids in secondhand cannabis smoke 二手大麻烟雾中的多环芳烃和大麻素
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-28 DOI: 10.1016/j.envint.2026.110175
Xiaochen Tang , Abel S. Huang , Marion L. Russell , Gideon St. Helen , Peyton Jacob III , Hugo Destaillats , Suzaynn F. Schick
The legalization of cannabis is exposing more people to secondhand smoke (SHS) generated during cannabis use. Given the serious health effects caused by tobacco SHS, there is a need to assess the potential health effects of exposure to cannabis SHS. As a step toward this, we measured the concentrations of cannabinoids, nicotine and polycyclic aromatic hydrocarbons (PAHs) in air samples collected in public places where cannabis was being consumed. These were compared with concentrations in exhaled aerosols from cannabis smoking and vaping, and in tobacco SHS. Tetrahydrocannabinol concentrations were 22 to 255 µg/m3 in field samples, below the threshold for psychoactive effects. Nicotine concentrations in field samples did not exceed 1 µg/m3. The total PAH concentrations in field samples were from 3.2 to 80.5 ng/m3, depending on location type. By contrast, PAH levels averaged 72 ng/m3 in tobacco SHS and 220 ng/m3 in the more concentrated, exhaled cannabis aerosols. A total of 22 different PAHs were identified in field samples of cannabis aerosols, from which benz[a]anthracene (B[a]A) was present in the highest concentrations. The PAH profile of cannabis aerosols was different from that of tobacco SHS. A preliminary cancer risk evaluation showed that the dose associated with inhalation of cannabis SHS during an 8-h work shift exceeded the California No Significant Risk Level for B[a]A at all venues where cannabis was consumed primarily via smoking. In summary, the consumption of cannabis, by smoking and by vaporizing, can create aerosols that contain carcinogenic PAHs. Thus breathing secondhand cannabis aerosols increases exposure to carcinogens.
大麻合法化使更多的人暴露在吸食大麻过程中产生的二手烟(SHS)中。鉴于烟草二手烟对健康造成的严重影响,有必要评估接触大麻二手烟对健康的潜在影响。为了实现这一目标,我们测量了在吸食大麻的公共场所收集的空气样本中大麻素、尼古丁和多环芳烃(PAHs)的浓度。这些浓度与吸食大麻和电子烟以及烟草SHS呼出的气溶胶浓度进行了比较。现场样品中的四氢大麻酚浓度为22 ~ 255 µg/m3,低于精神活性作用的阈值。现场样品中尼古丁浓度不超过1 µg/m3。现场样品中多环芳烃的总浓度在3.2 ~ 80.5 ng/m3之间,根据位置类型而定。相比之下,烟草SHS中的多环芳烃平均含量为72 ng/m3,而更浓缩的呼出的大麻气溶胶中的多环芳烃平均含量为220 ng/m3。在大麻气雾剂的现场样品中共鉴定出22种不同的多环芳烃,其中苯[A]蒽(B[A]A)的浓度最高。大麻气溶胶的多环芳烃分布与烟草SHS不同。一项初步的癌症风险评估显示,在8小时轮班期间吸入大麻SHS的相关剂量超过了加州对B[A]A的无显著风险水平,在所有主要通过吸烟消费大麻的场所。总而言之,大麻的消费,通过吸烟和蒸发,可以产生含有致癌多环芳烃的气溶胶。因此,吸入二手大麻气溶胶会增加接触致癌物质的机会。
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引用次数: 0
Impact of regulatory actions to establish maximum contaminant levels on per- and polyfluoroalkyl substances in New Jersey public water systems 为确定新泽西州公共供水系统中全氟烷基和多氟烷基物质的最大污染物水平而采取的管制行动的影响。
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-28 DOI: 10.1016/j.envint.2026.110179
Hari S. Iyer , Stefanie A. Joseph , Julianne Varga , Chidinma Opara , Judith M. Graber , Robert J. Laumbach , Panos G. Georgopoulos , Jaime E. Hart , Gloria B. Post , Emily S. Barrett

Background

The U.S. Environmental Protection Agency set drinking water Maximum Contaminant Levels (MCLs) for several PFAS in 2024, yet few evaluations of earlier state regulations have been conducted. We evaluated the impact of regulatory actions taken by the New Jersey Department of Environmental Protection (NJDEP) to set PFAS drinking water standards in NJ community water systems (CWS).

Methods

The NJDEP performed statewide testing of CWS PFAS levels in 2006 and 2009–2010, which were supplemented by additional CWS data reported to NJDEP and federal monitoring from 2013 to 2015 using methods including EPA method 537 and 537.1. The NJ Drinking Water Quality Institute formally recommended MCLs to NJDEP for PFNA (13 ng/L) in July 2015, for PFOA (14 ng/L) in March 2017, and PFOS (13 ng/L) in June 2018. Routine CWS monitoring began in 2019, covering the study period of 2006–2025. Quarterly PFOA, PFOS, and PFNA testing results were obtained from 47 CWS with monitoring data before and after the MCL recommendations. Using linear regression, we fit interrupted time series models to estimate the change and trend in PFAS levels following proposed MCLs.

Results

We obtained 4,150, 4,086, and 4,053 monitoring results for PFOA, PFOS, and PFNA, respectively. We observed declines in the proportion of PFOA (49.3% v s 14.9%), PFOS (11.6% vs 3.5%), and PFNA (23.6% vs 1.5%) results above the MCL following recommendation of PFAS regulations (chi-squared P < 0.001). There was a 55% (95% CI: 11%, 77%) and 50% (95% CI: 14%, 71%) decline in PFOA and PFNA levels, respectively, following recommendation of MCLs. There were declines in quarterly trend in PFOS (2%, 95% CI: 0%, 5%) and PFNA levels (6%, 95% CI: 2%, 9%).

Discussion

Regulated PFAS levels declined following formal recommendation of MCLs to NJDEP. Actions taken toward establishing regulations to limit drinking water PFAS exposures can achieve substantial reductions.
背景:美国环境保护署在2024年为几种PFAS设定了饮用水最大污染物水平(MCLs),但很少对早期的州法规进行评估。我们评估了新泽西州环境保护部(NJDEP)在新泽西州社区水系统(CWS)中制定PFAS饮用水标准所采取的监管行动的影响。方法:NJDEP于2006年和2009-2010年在全州范围内检测了CWS PFAS水平,并通过2013 - 2015年向NJDEP报告的额外CWS数据和联邦监测(采用EPA方法537和537.1)进行了补充。2015年7月,新泽西州饮用水质量研究所正式向NJDEP推荐了PFNA (13 ng/L)的mcl, 2017年3月推荐了PFOA (14 ng/L), 2018年6月推荐了PFOS (13 ng/L)。常规CWS监测于2019年开始,研究期间为2006-2025年。在MCL建议前后对47个CWS进行监测,获得季度PFOA、PFOS和PFNA检测结果。使用线性回归,我们拟合中断时间序列模型来估计在提出的mcl后PFAS水平的变化和趋势。结果:我们分别获得了4,150、4,086和4,053个PFOA、PFOS和PFNA的监测结果。我们观察到PFOA (49.3% vs 14.9%)、PFOS (11.6% vs 3.5%)和PFNA (23.6% vs 1.5%)结果在PFAS法规推荐后高于MCL的比例下降(讨论:在正式推荐MCL到NJDEP后,受调节的PFAS水平下降。为建立限制饮用水中PFAS暴露的法规而采取的行动可以实现大幅减少。
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引用次数: 0
Heatwaves and PM2.5 from wildfire smoke, non-wildfire sources, and all sources in relation to preterm birth: a nationwide cohort study in Canada 野火烟雾、非野火来源以及与早产有关的所有来源的热浪和PM2.5:加拿大的一项全国性队列研究
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-03-07 DOI: 10.1016/j.envint.2026.110185
Qingyi Lan , Sarah Henderson , Eric Coker , Naman Paul , Stephanie E Cleland , Jessica Evans , Li Chen , Annalise Ferro , Jean-Nicolas Côté , Alana Maltby , Piotr Wilk , Eric Lavigne

Background

With climate change, the frequency and intensity of heatwaves and wildfires are increasing. We examined the independent associations of acute heatwaves and wildfire smoke-impacted particulate matter ≤2.5  µm diameter (PM2.5) with preterm birth outcomes, and their combined effects.

Methods

We conducted a nationwide population-based cohort study of singleton births in Canada (2010–2021). Temperature and PM2.5 exposure during each gestational week were assigned from satellite data and a machine learning-based prediction model, respectively. Heatwaves were defined as 95th or 98th percentile regional weekly temperatures lasting 2–4 days (denoted as 95th-D2/D3/D4, 98th-D2/D3). PM2.5 was categorized by regional percentile bins (≤50th [ref.], 50–75th, 75–90th, >90th) and absolute bins (<6 µg/m3, ≥6–8 µg/m3, ≥8–10 µg/m3, ≥10–12 µg/m3, ≥12–14 µg/m3, ≥14–16 µg/m3, and ≥ 16 µg/m3). Cox models assessed independent effects, and the relative excess risk due to interaction (RERI) assessed combined effects.

Results

Among 2,569,810 singleton births, 80,757 (3.1%) were preterm. Both PM2.5 and heatwaves were independently associated with an increased risk of preterm birth. We observed a synergistic interaction (RERI > 0) between heatwaves and non-wildfire PM2.5 that increased in magnitude with higher concentration percentiles. The magnitude of this interaction increased as the heatwave threshold rose from 95th to 98th percentile, and as the duration increase from 2 to 4 days. Notably, the synergistic risk associated with 95th-D3 heatwaves and moderate (50th–75th) relative concentrations of wildfire smoke-impacted PM2.5 (RERI = 0.35; 95% CI: 0.05, 0.65) was more than double the synergistic risk observed for corresponding moderate non-wildfire PM2.5 (RERI = 0.16; 95% CI: 0.07, 0.25).

Conclusions

Co-exposure to PM2.5 and heatwaves exerts a synergistic effect on preterm birth risk that is significantly amplified when the particulate matter originates from wildfires. These findings highlight the need for early warning systems and public health messaging targeting moderate wildfire smoke events.
随着气候变化,热浪和野火的频率和强度都在增加。我们研究了急性热浪和野火烟雾影响的颗粒物 ≤2.5 µm直径(PM2.5)与早产结局的独立关联,以及它们的综合效应。方法:我们在加拿大进行了一项基于全国人口的单胎出生队列研究(2010-2021)。每个妊娠周的温度和PM2.5暴露分别来自卫星数据和基于机器学习的预测模型。热浪定义为持续2-4 天的第95或第98百分位区域周温度(记为95 - d2 /D3/D4, 98 - d2 /D3)。PM2.5按区域百分位仓(≤50[参考文献],50 - 75,75 - 90,>90)和绝对仓(<6µg/m3,≥6 - 8 µg/m3,≥8-10 µg/m3,≥10-12 µg/m3,≥12-14 µg/m3,≥14-16 µg/m3, ≥ 16 µg/m3)分类。Cox模型评估独立效应,相互作用的相对超额风险(relative excess risk due to interaction, RERI)评估联合效应。结果2569810例单胎分娩中,早产80757例(3.1%)。PM2.5和热浪都与早产风险增加独立相关。我们观察到热浪和非野火PM2.5之间的协同相互作用(rei > 0),其强度随着浓度百分位数的增加而增加。随着热浪阈值从第95百分位增加到第98百分位,随着持续时间从2 天增加到4 天,这种相互作用的强度增加。值得注意的是,95 - d3级热浪和中度(50 - 75)野火烟雾影响PM2.5的协同风险(rei = 0.35; 95% CI: 0.05, 0.65)是相应中度非野火PM2.5的协同风险的两倍多(rei = 0.16; 95% CI: 0.07, 0.25)。结论PM2.5与热浪暴露对早产风险具有协同效应,且当PM2.5来源于森林大火时,该效应被显著放大。这些发现强调了针对中度野火烟雾事件建立早期预警系统和公共卫生信息的必要性。
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引用次数: 0
High-resolution modelling of organic aerosol over Europe: exploring spatial and temporal variability and drivers 欧洲有机气溶胶的高分辨率模拟:探索空间和时间变化及其驱动因素
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.envint.2026.110143
Daniel Trejo Banos , Abhishek Upadhyay , Yun Cheng , Jianhui Jiang , Petros Vasilakos , Andrea Nava , Pavol Ševera , Benjamin Flueckiger , Aikaterini Bougiatioti , Ana Maria Sanchez De La Campa Verdona , Andrea Schemmel , Andrés Alastuey , Anikó Vasanits , Anna Font , Anna Tobler , Aude Bourin , Attila Machon , Benjamin Chazeau , Benjamin Bergmans , Célia A. Alves , Imad El Haddad
Organic aerosol (OA) is a major component of atmospheric particulate matter (PM), affecting both human health and climate. However, high-resolution estimates of OA exposure needed for exposure analysis remain scarce. Here, we integrate a chemical transport model (CAMx) with a random forest (RF) machine learning approach to bias-correct and downscale daily OA concentrations across Europe. CAMx OA simulations at ∼15 km resolution show moderate agreement with observations (r = 0.55). By combining these outputs with high-resolution land-use data and training the RF model on ∼48,000 daily OA measurements from 137 sites, prediction accuracy improved (r = 0.65), with ∼l5% reduction in root mean square error. The resulting maps provide European daily OA concentrations at ∼250 m resolution for alternate years from 2011 to 2019. The model captures key spatial features, including elevated OA in the Po Valley, Southeastern, and Central Europe, as well as intracity variations due to local hotspots. Seasonal analysis reveals higher concentrations in winter, while long-term trends indicate a general decline in OA levels. Exposure estimates show that half of the European population experiences OA levels above 3 µg/m3, and ∼50 million people are exposed to more than 5 µg/m3, which is the current guideline level recommended by the world health organization for total PM2.5. These high-resolution OA maps offer vital critical support for epidemiological research and air quality policy.
有机气溶胶(OA)是大气颗粒物(PM)的主要组成部分,影响人类健康和气候。然而,暴露分析所需的OA暴露的高分辨率估计仍然很少。在这里,我们将化学传输模型(CAMx)与随机森林(RF)机器学习方法集成在一起,以校正偏差并缩小整个欧洲的每日OA浓度。CAMx OA模拟在~ 15 km分辨率下显示与观测值有一定的一致性(r = 0.55)。通过将这些输出与高分辨率土地利用数据相结合,并对来自137个站点的约48,000个每日OA测量数据进行RF模型训练,预测精度得到了提高(r = 0.65),均方根误差降低了约15%。由此产生的地图提供了2011年至2019年交替年份的欧洲每日OA浓度,分辨率为~ 250米。该模型捕捉了关键的空间特征,包括波河流域、东南部和中欧的高OA,以及由于局部热点引起的城市变化。季节分析显示冬季浓度较高,而长期趋势表明OA水平普遍下降。暴露估计表明,半数欧洲人口的OA水平高于3微克/立方米,约5000万人的暴露水平超过5微克/立方米,这是世界卫生组织目前建议的PM2.5总量指导水平。这些高分辨率OA地图为流行病学研究和空气质量政策提供了至关重要的支持。
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引用次数: 0
Systematic evidence map on the association between exposure to personal care products and fetal growth 接触个人护理产品与胎儿生长之间关系的系统证据图
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.envint.2026.110147
Paige A. Bommarito , Kyla W. Taylor , Andrew A. Rooney , Kezia Addo , Scott S. Auerbach , Robyn B. Blain , Kelly K. Ferguson , Symielle A. Gaston , Samantha M. Hall , Chandra L. Jackson , Courtney Lemeris , Raquel Silva , Wren Tracy , Vickie R. Walker , Kembra L. Howdeshell

Background

Exposure to environmental chemicals can influence fetal growth, and these alterations are associated with adverse health outcomes across the lifespan. Personal care products (PCPs) are frequently used by women of reproductive age, including many chemicals known to adversely impact fetal development. Given the high number of chemicals in PCPs, a class-based approach of grouping these chemicals by common characteristic(s) (e.g., chemical structure, mode of action) may support future hazard identification evaluations.

Objectives

To develop a systematic evidence map (SEM) identifying and characterizing the scientific literature on gestational exposure to PCPs or their chemical constituents and fetal growth to support potential chemical class-based assessments.

Methods

Following standardized systematic review methodology, three databases were searched for relevant human and experimental animal studies through June 2024. Study characteristics were extracted and summarized in interactive visualizations and text.

Results

Of the four main chemical classes assessed, phthalates and phenols were most frequently studied (40% and 30% of studies, respectively), followed by per- and polyfluoroalkyl substances (PFAS), and parabens. Few studies evaluated product use. Birthweight was the most frequently assessed outcome (approximately 99% of studies). Many human studies evaluated potential modifying factors of health (% of studies), such as infant sex (58%), race and ethnicity (7%), and socioeconomic status (1%).

Discussion

Given the availability of well-studied “anchor” chemicals within related chemical groups, this SEM supports the feasibility of class-based approaches to evaluate the association between phthalates, PFAS, phenols, and parabens and fetal growth. Further research on PCPs and fetal growth should address areas of uncertainty, including data gaps on potential effect modifiers, such as socioeconomic status.
暴露于环境中的化学物质会影响胎儿的生长,而这些变化与终生的不良健康结果有关。育龄妇女经常使用个人护理产品(pcp),其中包括许多已知对胎儿发育有不利影响的化学物质。鉴于pcp中的化学品数量众多,按共同特征(如化学结构、作用方式)对这些化学品进行分类的基于类别的方法可能支持未来的危害识别评估。目的建立一个系统的证据图(SEM),识别和描述妊娠期暴露于pcp或其化学成分和胎儿生长的科学文献,以支持潜在的基于化学类别的评估。方法采用标准化的系统评价方法,检索截至2024年6月的三个数据库中相关的人类和实验动物研究。在交互式可视化和文本中提取和总结了研究特征。结果在评估的四种主要化学类别中,邻苯二甲酸酯和酚类是研究最多的(分别占研究的40%和30%),其次是全氟烷基和多氟烷基物质(PFAS),以及对羟基苯甲酸酯。很少有研究评估产品的使用。出生体重是最常见的评估结果(约99%的研究)。许多人体研究评估了健康的潜在改变因素(占研究的%),如婴儿性别(58%)、种族和民族(7%)和社会经济地位(1%)。考虑到相关化学基团中“锚定”化学物质的可用性,该扫描电镜支持基于类别的方法评估邻苯二甲酸酯、PFAS、酚类和对羟基苯甲酸酯与胎儿生长之间关系的可行性。对pcp和胎儿生长的进一步研究应该解决不确定的领域,包括潜在影响调节因素的数据缺口,如社会经济地位。
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引用次数: 0
Independent and interactive effects of wet bulb globe temperature and air pollution exposures on suicide mortality 湿球温度和空气污染暴露对自杀死亡率的独立和交互影响
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-21 DOI: 10.1016/j.envint.2026.110152
Dirga Kumar Lamichhane , James A. VanDerslice , Fred Lurmann , Nathan R. Pavlovic , Michael J. Staley , Douglas S. Tharp , Alina Peluso , Brandy M. Byrwa-Hill , Yue Zhang , Anna R. Docherty , Hilary Coon , Amanda V. Bakian

Background

Individual components of the ambient environment, such as temperature and air pollution, exist as part of a complex mixture and have been associated with suicide; however, their interactive effects remain poorly understood. This study examined the independent and interactive effects of wet bulb globe temperature (WBGT), nitrogen dioxide (NO2), and fine particulate matter (PM2.5) on suicide mortality.

Methods

We identified 7,551 suicide cases in Utah, USA, from 2000 to 2016 and assigned exposure to daily maximum WBGT (sourced from the European Center for Medium-Range Weather Forecasts) and PM2.5 and NO2 concentrations (sourced from a national spatiotemporal ensemble model) using decedent’s residential address at the time of death. A case-crossover design with conditional logistic regression was used to estimate the independent and interactive effects of WBGTmax, PM2.5, and NO2 on suicide. For exposure windows, we considered single days preceding suicide (lag 0 to 6) and their averages across preceding days (lag 0–1, 0–3, and 0–6). Analyses were stratified by season.

Results

We identified a significant association between WBGTmax and suicide across all seasons (odds ratio [OR] = 1.05, 95% confidence interval [CI]: 1.01, 1.10; per 5 °C increase on lag 0–3 days). The associations were stronger in the warm season (March 22 to September 21), with ORs and 95% CIs ranging from 1.08 (1.02, 1.15) to 1.20 (1.10, 1.30) per 5 °C increase depending on the lag periods. We observed synergistic interactions between WBGTmax and PM2.5 and NO2 in the warm season, associated with higher odds of suicide. The associations of WBGTmax with suicide were most pronounced at high NO2 levels.

Conclusions

We found evidence of synergistic interactions between WBGTmax and PM2.5 and NO2 on suicide in the warm season, emphasizing the need for considering the combined effects of heat stress and air pollution in suicide prevention strategies.
环境的个别成分,如温度和空气污染,作为复杂混合物的一部分存在,并与自杀有关;然而,它们的相互作用仍然知之甚少。本研究考察了全球湿球温度(WBGT)、二氧化氮(NO2)和细颗粒物(PM2.5)对自杀死亡率的独立和交互影响。方法:选取2000年至2016年美国犹他州7551例自杀病例,并使用死者死亡时的居住地址,分配每日最大WBGT(来自欧洲中期天气预报中心)和PM2.5和NO2浓度(来自国家时空集合模型)。采用病例交叉设计和条件logistic回归来估计WBGTmax、PM2.5和NO2对自杀的独立和交互影响。对于暴露窗口,我们考虑自杀前的一天(滞后0 - 6)及其前几天的平均值(滞后0 - 1、0 - 3和0 - 6)。分析按季节分层。结果我们发现在所有季节WBGTmax与自杀之间存在显著关联(优势比[OR] = 1.05, 95%可信区间[CI]: 1.01, 1.10;滞后0-3天每增加5°C)。在暖季(3月22日至9月21日),相关性更强,随滞后期的不同,每增加5°C的or和95% ci在1.08(1.02,1.15)至1.20(1.10,1.30)之间。我们观察到暖季WBGTmax与PM2.5和NO2之间的协同相互作用,与较高的自杀率相关。WBGTmax与自杀的关联在高NO2水平时最为明显。结论暖季WBGTmax与PM2.5和NO2对自杀有协同作用,强调在预防自杀策略中需要考虑热应激和空气污染的联合作用。
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引用次数: 0
Long-term exposure to air pollution and 5-year mortality after lung cancer diagnosis: a Danish nurse cohort study 长期暴露于空气污染和肺癌诊断后的5年死亡率:丹麦护士队列研究
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI: 10.1016/j.envint.2026.110168
Sophie MA Effing , Jiawei Zhang , Stéphane Tuffier , Thomas Cole-Hunter , Marie Bergmann , George Maria Napolitano , Rina So , Jørgen Brandt , Matthias Ketzel , Steffen Loft , Jaime E Hart , Youn-Hee Lim , Zorana Jovanovic Andersen
While the association between air pollution and lung cancer is well established, its relationship with post-diagnosis mortality remains limited, especially in low-exposure settings. We investigated the association of long-term exposure to air pollution with 5-year mortality after lung cancer diagnosis in Denmark. In this nested cohort, we included 449 participants from the Danish Nurse Cohort who were diagnosed with lung cancer between their baseline year (1993/1999) and 2020. We estimated mean residential annual concentrations of particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), elemental carbon (EC), and ozone (O3) using DEHM/UBM/AirGIS. We used time-varying Cox regression models to minimize immortal time bias (ITB), adjusting for age, baseline year, date of diagnosis, time since diagnosis, smoking, socioeconomic factors, and additional lifestyle variables. Of the 449 participants diagnosed with primary lung cancer, 377 died within 5 years after diagnosis. Hazard ratios (HRs) per interquartile range increase in 5-year moving average exposures were 0.99 (95% CI: 0.71–1.39) for PM2.5, 0.93 (0.71–1.22) for PM10, 0.99 (0.84–1.17) for NO2, 0.95 (0.82–1.09) for EC, and 1.04 (0.89–1.22) for O3 in the fully adjusted model. A methodological comparison demonstrated that time-fixed exposure averaging substantially overestimated associations (PM2.5: HR 3.00 vs. 0.99), confirming the importance of time-varying approaches to avoid ITB. We found no association between long-term air pollution exposure and 5-year mortality in Danish female nurses diagnosed with lung cancer. Our study provides valuable evidence on this scarcely researched topic and highlights the critical methodological consideration of ITB in survival analyses with time-varying environmental exposures.
虽然空气污染与肺癌之间的联系已经确立,但其与诊断后死亡率的关系仍然有限,特别是在低暴露环境中。我们调查了长期暴露于空气污染与丹麦肺癌诊断后5年死亡率的关系。在这个嵌套队列中,我们纳入了449名来自丹麦护士队列的参与者,他们在基线年(1993/1999)至2020年期间被诊断患有肺癌。我们使用DEHM/UBM/AirGIS估算了居民年平均颗粒物(PM2.5和PM10)、二氧化氮(NO2)、单质碳(EC)和臭氧(O3)浓度。我们使用时变Cox回归模型来最小化不朽时间偏差(ITB),调整年龄、基线年、诊断日期、诊断后的时间、吸烟、社会经济因素和其他生活方式变量。在449名被诊断为原发性肺癌的参与者中,377人在诊断后5 年内死亡。在完全调整模型中,PM2.5的5年移动平均暴露每四分位数范围增加的风险比(hr)为0.99 (95% CI: 0.71-1.39), PM10为0.93 (0.71-1.22),NO2为0.99 (0.84-1.17),EC为0.95 (0.82-1.09),O3为1.04(0.89-1.22)。一项方法学比较表明,时间固定暴露平均大大高估了相关性(PM2.5: HR 3.00 vs. 0.99),证实了时变方法对避免ITB的重要性。我们发现长期空气污染暴露与诊断为肺癌的丹麦女护士的5年死亡率之间没有关联。我们的研究为这个很少被研究的话题提供了有价值的证据,并强调了在时变环境暴露的生存分析中对ITB的关键方法学考虑。
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引用次数: 0
Unmasking indoor exposure profiles in vulnerable households: an unsupervised clustering of integrated environmental and demographic data 揭露脆弱家庭室内暴露概况:综合环境和人口数据的无监督聚类
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-28 DOI: 10.1016/j.envint.2026.110167
Hye-Shin Kim , Seohyun Yoo , Joonseo Hyeon, Jaehyuk Cho
Indoor air quality (IAQ) represents a complex interplay of exposures that single-pollutant studies often fail to capture. Identifying holistic exposure profiles is critical for understanding health risks in populations spending the majority of their time indoors. We integrated high-resolution environmental sensor data with demographic and behavioral metadata from residential testbeds. To handle the high-dimensional, heterogeneous data, we first engineered temporal and health-relevant categorical variables. We then applied Factor Analysis of Mixed Data (FAMD) followed by Uniform Manifold Approximation and Projection (UMAP) for dimensionality reduction. On this reduced feature space, we employed Torque clustering, a parameter-free algorithm, to identify stable exposure patterns. The resulting profiles were characterized using heatmaps and Z-score-based radar charts, and statistically validated through odds ratio (OR) analysis. The analysis identified six stable and distinct exposure profiles that remained consistent across different time periods. Key profiles included an acoustic-dominated group (Cluster 0), hot-and-humid physical environment groups (Clusters 1 & 2), and chemical-dominant groups (Clusters 4 & 5), all compared against a low-exposure reference group (Cluster 3). Specifically, Cluster 2, characterized by an older adult demographic, represented a ’multi-hazard’ group with the highest relative risk for adverse TVOCs levels (OR ≈ 50). These profiles were significantly associated with demographic and behavioral factors, including age, housing type, and gas stove use. This study demonstrates that unsupervised clustering can systematically stratify heterogeneous indoor exposures into robust, interpretable profiles. By moving beyond single-pollutant assessment, this data-driven approach provides a powerful framework for precision environmental health strategies by enabling cluster-specific risk stratification and targeted interventions.
室内空气质量(IAQ)代表了暴露的复杂相互作用,单一污染物的研究往往无法捕获。确定整体暴露概况对于了解大部分时间在室内度过的人群的健康风险至关重要。我们将高分辨率环境传感器数据与来自住宅测试平台的人口统计和行为元数据集成在一起。为了处理高维异构数据,我们首先设计了时间和健康相关的分类变量。然后,我们应用混合数据因子分析(FAMD),然后是均匀流形逼近和投影(UMAP)进行降维。在此简化的特征空间上,我们采用无参数算法Torque clustering来识别稳定的暴露模式。使用热图和基于z分数的雷达图对所得剖面进行表征,并通过比值比(OR)分析进行统计验证。分析确定了在不同时期保持一致的六种稳定而独特的暴露谱。关键概况包括声学主导组(集群0)、湿热物理环境组(集群1和集群2)和化学主导组(集群4和集群5),所有这些都与低暴露参考组(集群3)进行了比较。具体而言,以老年人人口统计为特征的集群2代表了一个“多危害”组,其有害TVOCs水平的相对风险最高(OR ≈ 50)。这些特征与人口统计学和行为因素显著相关,包括年龄、住房类型和煤气灶使用情况。该研究表明,无监督聚类可以系统地将异质室内暴露分层为稳健的,可解释的剖面。通过超越单一污染物评估,这种数据驱动的方法通过实现特定集群的风险分层和有针对性的干预措施,为精确的环境卫生战略提供了一个强大的框架。
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引用次数: 0
Attenuation of sulfamethoxazole and associated antimicrobial resistome by enriched electroactive microbial consortia 富电活性菌群对磺胺甲恶唑及相关抗菌素的衰减作用
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-03-04 DOI: 10.1016/j.envint.2026.110182
Xu Li , Ze Sun , Lizhou Lin , Tongchu Deng , Meiying Xu
Electroactive biofilms with the capacity of extracellular electron transfer (EET) have shown great promise for mitigating antibiotics and antibiotic resistance genes (ARGs). However, detailed interactions between antibiotics and electroactive microorganisms, along with ARGs dissemination dynamics within the electroactive consortia, remained poorly understood. In this study, stable electroactive microbial consortia were enriched, and their influences on the fates of sulfamethoxazole (SMX) and associated ARGs were systematically investigated. The results showed the enriched consortia could degrade SMX effectively within a wide concentration range through co-metabolism which was stimulated by their electrogenic respiration. Moreover, with accelerated SMX removal, the abundances of associated ARGs including sul1 and sul2 in the consortia decreased significantly due to alleviated SMX-induced selective pressure and probably weakened horizontal gene transfer mediated by mobile genetic elements (e.g., IS91 and tnpA). Degrader isolation and metagenomic analysis identified the core EET-proficient genera (e.g., Geobacter and Alcaligenes) as essential for the accelerated co-metabolism biodegradation of SMX, whereas the proliferation of other bacteria with limited or no EET capacity (e.g., Hydrogenophaga, Burkholderia, Comamonas, Desulfovibrio and Pseudomonas) was closely linked to the ARGs dissemination. This work provides a mechanistic elucidation of how electroactive microbial consortia stimulate antibiotic degradation and attenuate ARGs proliferation, offering strategic insights for risk control of the resistome during wastewater treatment.
具有细胞外电子转移(EET)能力的电活性生物膜在减轻抗生素和抗生素耐药基因(ARGs)方面显示出巨大的前景。然而,抗生素与电活性微生物之间的详细相互作用,以及ARGs在电活性菌群中的传播动态,仍然知之甚少。本研究富集了稳定的电活性微生物群落,并系统研究了它们对磺胺甲恶唑(SMX)及其相关ARGs的影响。结果表明,富集菌群可以通过电呼吸刺激的共代谢,在较宽的浓度范围内有效降解SMX。此外,随着SMX的加速去除,包括sul1和sul2在内的相关ARGs在群体中的丰度显著下降,这可能是由于SMX诱导的选择压力减轻,并可能减弱了由移动遗传元件(如IS91和tnpA)介导的水平基因转移。降解菌分离和元基因组学分析发现,核心的EET精通属(如Geobacter和Alcaligenes)对于加速SMX的共代谢生物降解至关重要,而其他有限或没有EET能力的细菌(如Hydrogenophaga、Burkholderia、Comamonas、Desulfovibrio和Pseudomonas)的增殖与ARGs的传播密切相关。这项工作提供了电活性微生物联合体如何刺激抗生素降解和减弱ARGs增殖的机制阐明,为废水处理过程中抵抗组的风险控制提供了战略见解。
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引用次数: 0
Unequal exposures, unequal attention: advancing environmental health research in rural areas 不平等的接触,不平等的关注:推进农村地区的环境卫生研究
IF 9.7 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-03-04 DOI: 10.1016/j.envint.2026.110173
Nicole C. Deziel , Michelle L. Bell
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引用次数: 0
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Environment International
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