Environmental Pollution最新文献_第3页

Association between air pollution and health outcomes in patients with IPF: A nationwide multicenter cohort study 空气污染与IPF患者健康结局的关系：一项全国性多中心队列研究

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI: 10.1016/j.envpol.2026.127886

Hee-Young Yoon , Sun-Young Kim , Sung Woo Park , Sun Mi Choi , Jongmin Lee , Hyung Koo Kang , Song Yee Kim , Hongseok Yoo , Jong Sun Park , Eun Joo Lee , Yong Hyun Kim , Jin Woo Song

Air pollution has been linked to the progression of idiopathic pulmonary fibrosis (IPF). However, studies in high-pollution areas examining a wide range of clinical outcomes remain limited. We aimed to investigate the association between individual air pollution exposure and health outcomes in a nationwide IPF cohort. This study included 1233 patients (mean age: 67.1 years, male: 76.3%) with IPF from 23 medical institutions. Individual exposure to nitrogen dioxide (NO₂) and particulate matter ≤10 μm (PM₁₀) was estimated from residential addresses using a national prediction model. Cox proportional hazards regression models analysed the association between air pollutant levels and mortality, acute exacerbation (AE), and disease progression (DP, defined as a relative 10% decline in forced vital capacity). Among 1233 patients, 60.7% died, 37.1% experienced AE, and 58.5% showed DP during a median follow-up of 63 months. In the primary model, adjusted for individual- and area-level covariates, each 10 parts per billion increase in NO₂ was linked to a 16.1% increased risk of mortality (hazard ratio [HR]: 1.161; 95% confidence interval [CI]: 1.000–1.331, p = 0.043) in patients with IPF. NO₂ exposure also tended toward association with DP (HR: 1.184; 95% CI: 0.990–1.438, p = 0.071). PM₁₀ exposure was significantly associated with time to the first occurrence AE (HR: 1.172; 95% CI: 1.020–1.344, p = 0.028) and showed a marginal association with AE frequency (incidence risk ratio: 1.149; 95% CI: 0.990–1.318, p = 0.059) in patients with IPF. Our data suggested that individual-level air pollution exposure may influence long-term clinical outcomes in patients with IPF.

空气污染与特发性肺纤维化（IPF）的进展有关。然而，在高污染地区检查广泛临床结果的研究仍然有限。我们的目的是在全国IPF队列中调查个人空气污染暴露与健康结果之间的关系。本研究纳入来自23家医疗机构的IPF患者1233例，平均年龄67.1岁，男性76.3%。使用国家预测模型估算了居民住址中二氧化氮（NO2）和≤10 μm颗粒物（PM10）的个体暴露量。Cox比例风险回归模型分析了空气污染物水平与死亡率、急性加重（AE）和疾病进展（DP，定义为强迫肺活量相对下降10%）之间的关系。在中位随访63个月期间，1233例患者中，60.7%死亡，37.1%发生AE， 58.5%出现DP。在初始模型中，对个体和区域水平的协变量进行调整后，IPF患者NO2浓度每增加十亿分之十，死亡风险增加16.1%（风险比[HR]: 1.161； 95%可信区间[CI]: 1.000-1.331, p = 0.043）。NO2暴露也倾向于与DP相关（HR: 1.184; 95% CI: 0.990-1.438, p = 0.071）。PM10暴露与IPF患者首次发生AE的时间有显著相关性（HR: 1.172; 95% CI: 1.020 ~ 1.344, p = 0.028），与AE频率有边际相关性（发病率风险比：1.149;95% CI: 0.990 ~ 1.318, p = 0.059）。我们的数据表明，个人水平的空气污染暴露可能会影响IPF患者的长期临床结果。

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引用次数: 0

UV-328 disrupts mineral nutrient homeostasis and secondary metabolism in Arabidopsis thaliana: Linking physiological responses to molecular mechanisms UV-328破坏拟南芥矿物质营养稳态和次生代谢：连接生理反应的分子机制

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-25 DOI: 10.1016/j.envpol.2026.127888

Ying Wang , Yaxin Zhu , Xintong Li , Qinghua Ma , Lukuan Huang , Ran Wu , Miaozhen Cai , Shaoting Du

The persistent benzotriazole ultraviolet stabilizer UV-328 is increasingly detected in agricultural soils, particularly under plastic mulch films, where its high hydrophobicity and bioaccumulation potential raise concerns for environmental and ecological risk assessment. Here, we systematically investigated the concentration-dependent effects of UV-328 (0-150 μM) on Arabidopsis thaliana using integrated multi-omics and physiological analyses. Our results demonstrated that 50 μM UV-328 promoted plant growth by 38% in shoot biomass while activating antioxidant enzyme gene expression, whereas whereas high concentrations caused biomass reduction and induced severe membrane lipid peroxidation. Notably, UV-328 disrupted mineral nutrient homeostasis and profoundly reprogrammed secondary metabolite profiles, including flavonoids, terpenoids, and nitrogen-containing compounds. Cross-omics network analysis coupled with molecular docking identified the nitrate transporter NRT1.1 and the phosphorus sensor SPX3 as high-affinity targets of UV-328. These findings establish UV-328–transporter binding as a mechanistic trigger of nutrient dysregulation and metabolic reprogramming, positioning nutrient homeostasis as a vulnerable endpoint for ecological risk assessment and a translational target for crop protection.

持久性苯并三唑类紫外线稳定剂UV-328在农业土壤，特别是地膜土壤中被越来越多地检测到，其高疏水性和生物积累潜力引起了人们对环境和生态风险评估的关注。本研究采用多组学和生理分析相结合的方法，系统研究了UV-328 （0 ~ 150 μM）对拟南芥的浓度依赖性。结果表明，50 μM UV-328在激活抗氧化酶基因表达的同时，能促进植物茎部生物量的38%的生长，而高浓度UV-328则会导致生物量减少，并引起严重的膜脂过氧化。值得注意的是，UV-328破坏了矿物质营养平衡，并深刻地重新编程了次生代谢物谱，包括黄酮类化合物、萜类化合物和含氮化合物。交叉组学网络分析结合分子对接发现硝酸盐转运体NRT1.1和磷传感器SPX3是UV-328的高亲和力靶点。这些发现表明，uv -328转运体结合是营养失调和代谢重编程的机制触发因素，将营养稳态定位为生态风险评估的脆弱终点和作物保护的转化目标。

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引用次数: 0

Comprehensive effects of different restoration modes on the ecological environment of abandoned land in typical Qinling mining areas: a systematic study based on PTEs pollution-vegetation-soil conditions 不同修复模式对秦岭典型矿区废弃地生态环境的综合影响——基于pte污染-植被-土壤条件的系统研究

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-26 DOI: 10.1016/j.envpol.2026.127878

Siwei Gao , Zhengyao Liu , Yue Wang , Jun Chen , Xinyan Pang , Yufeng Liu , Yeqi Geng , Qin Chen , Xiaoyan Huang , Zhibao Dong , Xiaoyun Li

Mining activities have boosted economic development but severely damaged the Qinling ecological environment, with potentially toxic elements (PTEs) pollution being particularly prominent. This study compared artificial and natural restoration by integrating PTEs contamination, vegetation diversity, and soil physicochemical properties. Results showed that after restoration, surface water pollution remained extremely severe—Pb, Cd, As, and Ni exceeded standards by 127.76, 136.40, 20.54, and 5.46 times respectively, while in soil, only Cd (4.40-19.82 times) and As (1.30-2.80 times) exceeded standards. Additionally, the heavy metal pollution index (HPI) of surface water in artificial restoration (8304) was significantly lower than that in natural restoration (11222) (P < 0.01), with richer vegetation diversity, but vegetation succession deviated from natural laws. No significant difference was observed in soil restoration efficacy between the two approaches, but the soil physicochemical properties (total colonies, soil organic matter, nitrogen content, soil organic carbon content, moisture content) had lower averages than natural restoration. These findings reflect the distinct short-term phased trajectories of the two restoration approaches: artificial restoration prioritizes vegetation coverage recovery, whereas natural restoration focuses on soil ecosystem stabilization. Finally, correlation analysis, Ridge regression, and structural equation modeling models indicated that vegetation diversity in artificial restoration was positively correlated with PTEs pollution, and the regulatory effect of soil properties on PTEs was weaker than that in natural restoration, suggesting natural restoration has higher adaptability, while artificial restoration has suboptimal vegetation selection and needs to be combined with natural restoration.

采矿活动促进了经济发展，但也严重破坏了秦岭的生态环境，潜在有毒元素（pte）污染尤为突出。本研究通过综合pte污染、植被多样性和土壤理化性质，对人工修复与自然修复进行了比较。结果表明，修复后地表水污染仍然非常严重，pb、Cd、As和Ni分别超标127.76倍、136.40倍、20.54倍和5.46倍，土壤中只有Cd（4.40 ~ 19.82倍）和As（1.30 ~ 2.80倍）超标。人工修复地表水重金属污染指数（HPI）为8304，显著低于自然修复地表水重金属污染指数（HPI）为11222 (P < 0.01)，植被多样性更丰富，但植被演替偏离自然规律。两种修复方式的土壤恢复效果无显著差异，但土壤理化性质（总菌落、土壤有机质、氮含量、土壤有机碳含量、水分含量）的平均值低于自然修复方式。这些发现反映了两种恢复方法不同的短期阶段轨迹：人工恢复优先于植被覆盖恢复，而自然恢复侧重于土壤生态系统的稳定。最后，相关分析、Ridge回归和结构方程模型表明，人工恢复植被多样性与pte污染呈正相关，土壤性质对pte的调节作用弱于自然恢复，表明自然恢复具有更高的适应性，而人工恢复具有次优的植被选择，需要与自然恢复相结合。

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引用次数: 0

Emissions of nitrogen oxide from household gaseous cooking 家庭气体烹饪产生的氮氧化物排放。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-03-03 DOI: 10.1016/j.envpol.2026.127915

Yongqiang Zhang , Jian Fu , Tianyao Huang , Jieyang Gao , Hanchen Wang , Ke Jiang , Ran Xing , Guofeng Shen , Shu Tao

Incomplete combustion of polluting solid fuels contributes severe air pollution, threatening public health, thus the transition toward clean modern energies is emphasized as one important Sustainable Development Goal. While gaseous fuels have been documented to significantly reduce particulate matter emissions, growing concerns highlight pollutants such as nitrogen oxides (mainly NO and NO₂) generated during the gas cooking could pose non-negligible risks to indoor air quality and residents’ health. This study systematically reviewed studies on nitrogen oxide emissions from household gas combustion, compiling fundamental datasets of emission factors (EFs) and emission rates (ERs), and evaluated factors contributing to emission variability. EFs are not normally distributed. The median values of NO and NO₂ EF are 22.2 ng/J and 9.1 ng/J, respectively, and the median EF for NOx, expressed as NO₂ equivalent, is 42.5 ng/J. The ERs for NO, NO₂ and NOx are 30.8, 11.6, and 58.8 mg/h, respectively. Using the bootstrap resampling method, the ratio of NO to NO₂ emissions is estimated as 2.65 (2.32–2.99 as the 95% confidence interval); however, this ratio varies depending on factors such as the air-to-fuel ratio, burner power, and loading height. Input power affects combustion temperature and thereby the formation of thermal NO, thus is an important factor determining NOx emissions. This study also compares methods of full-capture dilution tunnel facility, chamber, and carbon balance approach in emission studies, highlighting their technical advantages and limitations in different application scenarios. These results provide a scientific reference for formulating emission control strategies, optimizing appliance design standards, and establishing indoor air quality guidelines.

污染煤和生物质燃料的不完全燃烧造成严重的室内和环境空气污染，威胁到公众健康，因此向气体燃料的过渡被强调以实现可持续发展目标7-负担得起的清洁能源。虽然有文献证明现代燃气器具可以显著减少颗粒物排放，但人们越来越关注家庭燃气烹饪过程中产生的氮氧化物（主要是一氧化氮和二氧化氮）等污染物可能对室内空气质量和居民健康构成不可忽视的风险。本研究系统回顾了国内外关于家庭燃气燃烧氮氧化物排放的研究，编制了排放因子（EFs）和排放率（ERs）的基础数据集，并对影响排放变异性的因素进行了评估。电磁场不是正态分布的。NO和NO2 EF的中值分别为22.2 ng/J和9.1 ng/J， NOx的中值（以NO2当量表示）为42.5 ng/J。NO、NO2和NOx的er分别为30.8、11.6和58.8 mg/h。采用自举重采样法，估算出NO与NO2排放量之比为2.65(95%置信区间为2.32 ~ 2.99)；然而，这一比例受到空气-燃料比、燃烧器功率和负载高度等因素的影响。输入功率影响燃烧温度，从而形成热NO，是影响NOx生成的重要因素。本研究还比较了全捕集稀释隧道设施、室法和碳平衡法在排放研究中的应用，突出了它们在不同应用场景下的技术优势和局限性。这些结果为制定排放控制策略、优化家电设计标准和制定室内空气质量指南提供了科学参考。

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引用次数: 0

Multigenerational adaptation alters methylmercury uptake in cyanobacteria under warming and elevated CO2 多代适应在变暖和二氧化碳升高的情况下改变蓝藻对甲基汞的吸收

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI: 10.1016/j.envpol.2026.127838

Jin Zhang , Pei Lei , Yujiao Liu , Zhuoran Li , Han Meng , Huan He , Huan Zhong

Climate-driven increases in atmospheric CO₂ concentrations and temperature strongly regulate the physiology of phytoplankton, the primary entry point for neurotoxic methylmercury (MeHg) in aquatic food webs. How multigenerational adaptation to these stressors reshapes cellular traits governing MeHg uptake remains unclear. Here, we exposed the bloom-forming cyanobacterium Microcystis aeruginosa to long-term adaptation under elevated temperature (+5 °C) or CO₂ (+580 ppm), then quantified MeHg uptake and cellular partitioning. Both stressors reduced cellular MeHg accumulation by 36% under warming and 78% under elevated CO₂ compared to ambient conditions (25 °C, 420 ppm CO₂; p < 0.05). Short-term exposure (15 days) increased intracellular MeHg fractions from 33% (ambient) to 62% (warming) and 51% (elevated CO₂), but responses diverged over time (up to 330 days), declining under warming and rising under elevated CO₂. Mechanistically, warming stimulated secretion of extracellular soluble proteins that complexed MeHg, while elevated CO₂ reduced extracellular bound polysaccharides, limiting MeHg adsorption. These results reveal that climate-driven physiological acclimation and adaptation shape MeHg bioavailability in phytoplankton, highlighting the need to incorporate such processes into models predicting MeHg cycling and risks under climate change.

气候驱动的大气二氧化碳和温度的增加强烈地调节了浮游植物的生理，浮游植物是水生食物网中神经毒性甲基汞（MeHg）的主要入口。对这些压力源的多代适应如何重塑控制甲基汞摄取的细胞特征仍不清楚。在这里，我们将形成水华的蓝藻绿微囊藻暴露在高温（+ 5°C）或二氧化碳（+ 580 ppm）下进行长期适应，然后量化甲基汞的吸收和细胞分配。与环境条件（25°C, 420 ppm CO2）相比，这两种应激源使细胞甲基汞积累减少了36%（变暖）和78%（升高的CO2）（p < 0.05）。短期暴露（15天）使细胞内甲基汞含量从33%（对照组）增加到62%（变暖）和51%（二氧化碳浓度升高），但随着时间的推移（长达330天），反应出现分化，在变暖下下降，在二氧化碳浓度升高下上升。从机制上讲，变暖刺激了细胞外可溶性蛋白的分泌，使甲基汞络合，而升高的二氧化碳减少了细胞外结合的多糖，限制了甲基汞的吸附。这些结果表明，气候驱动的生理适应和适应塑造了浮游植物中甲基汞的生物利用度，强调了将这些过程纳入气候变化下甲基汞循环和风险预测模型的必要性。

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引用次数: 0

Enantioselective metabolic mechanism and metabolism pathway of tetraconazole in human liver microsomes: In vitro and in silico study 四康唑在人肝微粒体中的对映选择性代谢机制和代谢途径：体外和硅细胞研究。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-18 DOI: 10.1016/j.envpol.2026.127849

Shiling Liu, Junqi Zhu, Yu Wang, Wenyu Dai, Ya Zhou, Tengfei Zhang, Xianzhang Yang, Jingjing Wu, Yanmei Liu, Jie Luo, Huihua Tan, Feng Zhao

A comprehensive understanding of the enantioselective metabolic behaviors of tetraconazole within organisms is crucial for accurately evaluating their potential risks. Herein, human liver microsome assays showed that S-tetraconazole had a half-life of 14.98 min while R-tetraconazole had a half-life of 41.18 min. By specific CYP inhibitors, the key metabolizing enzyme for S-tetraconazole was identified as CYP3A4. Molecular docking revealed that R-tetraconazole (−8.39 kcal mol⁻¹) had lower binding energies with CYP3A4 than S-tetraconazole (−8.05 kcal mol⁻¹). Further, in vitro heterologous expression of CYP3A4 and mutation of the key amino acid arginine212 showed that wild-type CYP3A4 could rapidly and enantioselectivity metabolize S-tetraconazole, whereas the mutant not. Finally, nine tetraconazole metabolites were identified in liver microsomes, and M365, M369, and M285 were predicted more toxic than parent compounds. Overall, this study offers crucial reference for accurate risk assessment of tetraconazole from chiral level for protecting human health.

全面了解四康唑在生物体内的对端选择性代谢行为对于准确评估其潜在风险至关重要。其中，人肝微粒体检测显示s -四康唑的半衰期为14.98 min， r -四康唑的半衰期为41.18 min。通过特异性CYP抑制剂鉴定出s -四康唑的关键代谢酶为CYP3A4。分子对接发现，r -四康唑（-8.39 kcal mol-1）与CYP3A4的结合能低于s -四康唑（-8.05 kcal mol-1）。此外，CYP3A4的体外异源表达和关键氨基酸精氨酸212的突变表明，野生型CYP3A4能够快速和对端选择性地代谢s -四康唑，而突变型CYP3A4则不能。最后，在肝微粒体中鉴定出9种四环唑代谢物，预测M365、M369和M285比母体化合物毒性更大。本研究为从手性水平准确评估四康唑的风险，保护人体健康提供了重要参考。

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引用次数: 0

Genomic and phenotypic characterization of Aeromonas spp. from the longest river in Türkiye: Virulence, antibiotic, and heavy metal resistance 来自<s:1>基耶最长河流的气单胞菌的基因组和表型特征：毒力、抗生素和重金属抗性。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-18 DOI: 10.1016/j.envpol.2026.127852

Gizem Cufaoglu , Tansu Yildiz , Mukaddes Barel , Naim Deniz Ayaz

Kızılırmak River is the longest in Türkiye poses a potential contamination risk due to its use in intensive agriculture and livestock farming. This study characterizes Aeromonas spp. isolated from the Kızılırmak River by analyzing their antibiotic and heavy metal resistance profiles, virulence genes, biofilm formation, and genetic relatedness, including whole-genome sequencing of selected isolates. From 78 water samples collected across seven villages, 40 Aeromonas isolates were identified. A. veronii was the predominant species (85%), followed by A. hydrophila and A. eucrenophila. Phenotypic testing showed high carbapenem resistance, with 83% of isolates resistant to ertapenem and 50% to imipenem, and 52.5% of isolates classified as multidrug-resistant. The MAR index of 27 isolates exceeded the 0.2 threshold indicating high-risk contamination sources. Colistin MICs reached 16 μg/mL, especially in A. hydrophila isolates, and this was supported by the frequent detection of mcr-5 (100%) and mcr-3/7 (90%). Virulence genes act, aerA, and alt were highly prevalent, and biofilm assays revealed that 90% of the isolates exhibited moderate to strong biofilm formation. Heavy metal tolerance was observed, especially to copper, and this was supported by both MIC testing and PCR. Whole-genome sequencing of four selected A. veronii and A. hydrophila isolates revealed diverse resistance genes (including cphA, adeF, and OXA variants), chromosomally encoded virulence factors (T3SS, T4SS, T6SS) and mobile genetic elements. These findings suggest that Aeromonas spp. in the Kızılırmak River act as potential transmission routes for clinically relevant virulence traits, antimicrobial and heavy metal resistance, emphasizing the need for enhanced monitoring of aquatic environments impacted by agricultural and livestock-related contamination.

Kızılırmak河是全国最长的河，由于在集约化农业和畜牧业中使用，rkiye河具有潜在的污染风险。本研究通过分析从Kızılırmak河分离的气单胞菌的抗生素和重金属抗性谱、毒力基因、生物膜形成和遗传相关性，包括所选分离株的全基因组测序，来表征其特征。从7个村庄收集的78个水样中，鉴定出40株气单胞菌。优势种为维罗氏拟蚊（85%），其次为嗜水拟蚊和嗜绿拟蚊。表型检测显示碳青霉烯类耐药较高，对厄他培南耐药83%，对亚胺培南耐药50%，对多重耐药52.5%。27株分离物的MAR指数超过0.2阈值，为高危污染源。黏菌素的mic最高可达16 μg/mL，特别是在嗜水单胞菌分离株中，mcr-5（100%）和mcr-3/7（90%）的频繁检出也证实了这一点。毒力基因act、aerA和alt非常普遍，生物膜测定显示90%的分离株表现出中等至强的生物膜形成。观察到对重金属的耐受性，特别是对铜的耐受性，这得到了MIC测试和PCR的支持。选取的4株维罗氏单胞菌和嗜水单胞菌的全基因组测序结果显示，菌株具有多种抗性基因（包括cphA、adeF和OXA变体）、染色体编码的毒力因子（T3SS、T4SS、T6SS）和可移动遗传元件。这些研究结果表明，Kızılırmak河中的气单胞菌是临床相关毒力特征、抗微生物和重金属耐药性的潜在传播途径，强调需要加强对受农业和牲畜相关污染影响的水生环境的监测。

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引用次数: 0

Cyanidin-3-O-glucoside alleviates aflatoxin B1-induced splenic immunotoxicity via gut microbiota remodeling 花青素-3- o -葡萄糖苷通过肠道菌群重塑减轻黄曲霉毒素b1诱导的脾免疫毒性。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-20 DOI: 10.1016/j.envpol.2026.127856

Huiling Tang , Jordy Evan Sulaiman , Yuchen Zhang , Yuwei Yang , Jie Wang , Wujie Zhong , Hongtao Lei , Yunle Liu

While the hepatotoxicity of aflatoxin B₁ (AFB₁) is well characterized, its immunotoxicity remains overlooked. This study investigates whether cyanidin-3-O-glucoside (C3G), a bioactive polyphenolic flavonoid, can alleviate AFB₁-induced immunotoxicity. Our results demonstrated that C3G significantly ameliorated AFB₁-induced splenic injury, which was associated with the suppression of the NLRP3/caspase-1/GSDMD pyroptosis pathway and reduced expression of IL-1β and IL-18. Furthermore, C3G modulated the gut microbiota by enriching specific beneficial bacteria (e.g., Alistipes and Candidatus Saccharimonas) and reversed AFB₁-induced metabolic disorders. Transplantation of fecal microbiota from C3G-pretreated donor mice reproduced the protective effect of C3G in mice exposed to AFB₁, whereas sterile fecal filtrate transplantation only offered partial relief, indicating that the core mechanism depends on viable microbiota. In summary, C3G alleviates AFB₁-induced splenic injury by restructuring the dysbiotic gut microbiota into a more enriched community. This remodeling restores metabolic homeostasis and inhibits NLRP3-mediated pyroptosis via the gut-spleen axis. Our findings demonstrate that C3G alleviates AFB₁-induced splenic immunotoxicity by remodeling the gut microbiota via the gut-spleen axis, establishing a novel microbiota-dependent strategy mediated by natural polyphenols.

虽然黄曲霉毒素B1 （AFB1）的肝毒性已被很好地表征，但其免疫毒性仍被忽视。本研究探讨了具有生物活性的多酚类黄酮——花青素-3- o -葡萄糖苷（C3G）是否能减轻afb1诱导的免疫毒性。我们的研究结果表明，C3G显著改善了afb1诱导的脾损伤，这与抑制NLRP3/caspase-1/GSDMD焦亡通路和降低IL-1β和IL-18的表达有关。此外，C3G通过富集特定有益菌（如Alistipes和Candidatus Saccharimonas）来调节肠道微生物群，并逆转afb1诱导的代谢紊乱。经C3G预处理的供体小鼠的粪便微生物群移植在暴露于AFB1的小鼠中再现了C3G的保护作用，而无菌的粪便滤液移植仅提供部分缓解，表明其核心机制取决于活菌群。综上所述，C3G通过将益生菌群重组为更丰富的群落，减轻了afb1诱导的脾损伤。这种重塑可以恢复代谢稳态，并通过肠-脾轴抑制nlrp3介导的焦亡。我们的研究结果首次证明，C3G通过肠-脾轴重塑肠道微生物群，从而减轻afb1诱导的脾免疫毒性，建立了一种由天然多酚介导的新的微生物群依赖策略。

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引用次数: 0

The toxicity differences of lithium-ion battery cathode materials, lithium iron phosphate (LFP) and lithium cobalt oxide (LCO) to zebrafish(Danio rerio): Mechanisms and environmental impacts 锂离子电池正极材料磷酸铁锂（LFP）和氧化钴锂（LCO）对斑马鱼（Danio rerio）毒性差异：机制和环境影响

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-20 DOI: 10.1016/j.envpol.2026.127848

Xinhao Liu , Wanzhen Zhong , Ke Liu , YuanJie Cui , Lizhi Zhang , Weizhang Fu , Luolin Liu

The widespread use and improper disposal of lithium-ion batteries (LiBs) have raised increasing concerns regarding lithium-related contamination in aquatic ecosystems, yet the ecotoxicological effects and underlying mechanisms of representative cathode materials, lithium iron phosphate (LFP) and lithium cobalt oxide (LCO), remain poorly understood. In this study, the toxicological impacts of LFP and LCO (0, 1, 5, and 25 mg L⁻¹) on zebrafish were systematically investigated using an integrated multi-level approach encompassing biochemical assays, gene expression analysis, metabolomics, histopathology, molecular docking, and integrated biomarker response (IBRv2) assessment. Distinct material-specific toxicity profiles were observed: LFP exposure predominantly activated antioxidant defenses, accompanied by lipid peroxidation and disturbances in nitrogen metabolism, whereas LCO elicited concentration-dependent bidirectional regulation with pronounced heterogeneity across multiple physiological systems. Metabolomic analyses revealed that LCO mainly disrupted phospholipid metabolism, while LFP primarily affected branched-chain amino acid pathways. Histopathological examination confirmed organ-level damage, with more severe intestinal injury observed under LCO exposure. Molecular docking demonstrated stable interactions between both materials and key target proteins (e.g., SOD, LFABP, and Caspase3), mediated by hydrogen bonding and hydrophobic interactions. IBRv2 integration further highlighted stage-specific toxic responses and indicated a lower toxicity threshold for LCO compared to LFP. Overall, this study elucidates the differential toxicological mechanisms and relative ecological risks of LFP and LCO, providing a scientific basis for environmental risk assessment and the sustainable management of LiB-derived contaminants.

锂离子电池（LiBs）的广泛使用和不当处置引起了人们对水生生态系统中锂相关污染的日益关注，但代表性正极材料磷酸铁锂（LFP）和钴酸锂（LCO）的生态毒理学效应和潜在机制仍知之甚少。本研究采用生化分析、基因表达分析、代谢组学、组织病理学、分子对接和综合生物标志物反应（IBRv2）评估等多层次方法，系统研究了LFP和LCO（0、1、5和25 mg·L-1）对斑马鱼的毒理学影响。观察到不同的物质特异性毒性谱：LFP暴露主要激活抗氧化防御，伴随着脂质过氧化和氮代谢紊乱，而LCO引起浓度依赖的双向调节，在多个生理系统中具有明显的异质性。代谢组学分析显示，LCO主要破坏磷脂代谢，而LFP主要影响支链氨基酸途径。组织病理学检查证实了器官水平的损伤，在LCO暴露下观察到更严重的肠道损伤。分子对接表明材料与关键靶蛋白（如SOD、LFABP和Caspase3）之间通过氢键和疏水相互作用介导的稳定相互作用。IBRv2整合进一步强调了阶段特异性毒性反应，并表明与LFP相比，LCO的毒性阈值更低。总体而言，本研究阐明了LFP和LCO的不同毒理学机制和相对生态风险，为lib衍生污染物的环境风险评估和可持续管理提供了科学依据。

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引用次数: 0

Effect of picture-based indoor green walls on the physical and mental health of college students 基于图片的室内绿墙对大学生身心健康的影响

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-05-01 Epub Date: 2026-02-26 DOI: 10.1016/j.envpol.2026.127889

Conghui Jia , Limin Zhang , Yuqing Jin , Wenxuan Liu , Xiaoqin Song , Chongjian Wang , Zilin Zhou , Yuan Liu , Jing Wang , Huaifang Cai , Lei Yang , Yuming Guo

With increasing social focus on college students’ physical and mental health, picture-based indoor green walls emerge as a practical indoor space-integrated solution. The purpose of this study was to investigate the effects of picture-based indoor green wall exposure on the physical and mental health of college students. We conducted a 4-week intervention study of 311 undergraduate students in Shijiazhuang, China. Changes in their psychological responses were measured under conditions of exposure to non-green walls, a picture-based small green wall, and picture-based large green walls. Linear mixed-effects models were used to evaluate the relationship between green wall exposure and health indicators. We found that visual exposure to a picture-based green wall environment was associated with affective stress reduction, sleep quality improvement, and prospective and retrospective memory enhancement among college students, including decreased anxiety (−1.99, 95% confidence interval (CI): −3.13, −0.85), depression (−1.48, 95% CI: −2.09, −0.87), stress levels (−1.71, 95% CI: −2.71, −0.70), improved daytime sleepiness (−2.42, 95% CI: −3.25, −1.58), and prospective and retrospective memory (−5.86, 95% CI: −7.33, −4.38) compared to the non-green wall environment. The study showed the small green wall environment had the most significant impact on college students' well-being, improving mental health, sleep, and memory.

随着社会对大学生身心健康的日益关注，基于画面的室内绿墙作为一种实用的室内空间集成解决方案应运而生。摘要本研究旨在探讨以图片为基础的室内绿墙暴露对大学生身心健康的影响。我们对中国石家庄311名本科生进行了为期4周的干预研究。在暴露于非绿色墙壁、以图片为基础的小绿色墙壁和以图片为基础的大绿色墙壁的条件下，测量了他们心理反应的变化。使用线性混合效应模型来评估绿墙暴露与健康指标之间的关系。我们发现，在大学生中，视觉暴露于基于图片的绿色墙壁环境与情感性压力减轻、睡眠质量改善以及前瞻性和回顾性记忆增强有关，包括减少焦虑（- 1.99,95%置信区间（CI）： - 3.13, - 0.85）、抑郁（- 1.48,95% CI: - 2.09, - 0.87）、压力水平（- 1.71,95% CI: - 2.71, - 0.70）、改善白天嗜睡(- 2.42,95% CI：−3.25,−1.58)，前瞻性和回顾性记忆（−5.86,95% CI:−7.33,−4.38）与非绿墙环境相比。研究表明，小绿墙环境对大学生的幸福感、改善心理健康、睡眠和记忆力有最显著的影响。

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引用次数: 0