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Corrigendum to ‘Comparative evaluation of surface-level PM2.5 modeling across Northeast Asia: relevance for regulatory and scientific applications’ [Environ. Pollut. 377 (2025) 126428] 《东北亚地区地表PM2.5模型的比较评估:与监管和科学应用的相关性》的勘误表[environment]。污染。377 (2025)126428]
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127771
Hyeon-Kook Kim, EunRyoung Kim, Chang-Keun Song, Jae-Ho Choi, Ganghan Kim, Myong-In Lee, Yujin J. Oak, Rokjin J. Park, Ilhan Ryoo, Seung-Muk Yi, Kyung-Mi Lee, Hyeok-Gi Cheo, Kwon-Ho Jeon
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引用次数: 0
Bioaccumulation, trophic transfer, and health risk assessment of microplastics in the food web of Wuliangsuhai Lake, China: Higher risk for children 中国五粮素海食物网中微塑料的生物积累、营养转移和健康风险评估:对儿童的高风险
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127787
Guoliang Zhang, Jinhui Sun, Yiran Zhan, Bowen Xiao, Huamin Liu, Lixin Wang
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引用次数: 0
Polylactic acid microplastic exposure induced male reproductive toxicity and decreased testosterone levels by accelerating Leydig cell senescence 聚乳酸微塑料暴露通过加速间质细胞衰老诱导雄性生殖毒性和降低睾丸激素水平
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127778
Zhencheng Fan, Xinglong Wang, Yunqi Wu, Shuhao Li, Liang Kong, Shoujun Li, Tan Ma, Chun Pan
Polylactic acid microplastics (PLA-MPs), despite being marketed as biodegradable and eco-friendly alternatives to conventional plastics, have raised growing concerns regarding their potential adverse effects on human health. The reproductive toxicity of PLA-MPs exposure in male mammals has been confirmed in previous studies, but its specific effects on testosterone biosynthesis remain unclear. Male mice were treated with PLA-MPs at doses of low, medium, and high (0.01, 0.1, and 1 mg/d, respectively) for a duration of 28 days in this study. Our results demonstrated that PLA-MPs were enriched in mouse testes and led to a dose-dependent decrease in the serum testosterone concentration. We also observed the accumulation of senescent Leydig cells in the testis, along with inhibited autophagy and mitophagy. Moreover, we identified the critical involvement of autophagy and mitophagy in PLA-MPs-induced Leydig cell senescence. Re-establishment of autophagy and mitophagy effectively reserved the senescence of Leydig cell. Overall, our study revealed that PLA-MPs inhibit autophagy and mitophagy, thereby promoting Leydig cell senescence and subsequently reducing testosterone synthesis and secretion. These results advance our understanding of the pathogenic mechanisms underlying PLA-MPs-induced reproductive toxicity in male mammals.
聚乳酸微塑料(PLA-MPs)尽管被标榜为传统塑料的可生物降解和环保替代品,但其对人体健康的潜在不利影响引起了越来越多的关注。先前的研究已证实雄性哺乳动物暴露于PLA-MPs的生殖毒性,但其对睾酮生物合成的具体影响尚不清楚。在本研究中,雄性小鼠以低、中、高剂量(分别为0.01、0.1和1mg /d)的PLA-MPs治疗28天。我们的研究结果表明,PLA-MPs在小鼠睾丸中富集,并导致血清睾酮浓度呈剂量依赖性下降。我们还观察到睾丸中衰老的间质细胞的积累,同时自噬和有丝自噬受到抑制。此外,我们确定了自噬和有丝自噬在pla - mps诱导的间质细胞衰老中的关键作用。自噬和有丝自噬的重建有效地延缓了间质细胞的衰老。总的来说,我们的研究表明PLA-MPs抑制自噬和有丝分裂,从而促进间质细胞衰老,从而减少睾酮的合成和分泌。这些结果促进了我们对pla - mps诱导雄性哺乳动物生殖毒性的致病机制的理解。
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引用次数: 0
A Case-Control Study Linking Concentrations of Microplastics in Human Cerebrospinal Fluid to Intracranial Aneurysm Risk 人脑脊液中微塑料浓度与颅内动脉瘤风险的病例对照研究
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127788
Zebin Fang, Xiaoyi Wang, Fan Wu, Sihan Mao, Hao Jiang, Chi Hu, Luyuan Zhang, Weijian Fan, Chao Zhang, Ping Lan, Kaiyuan Huang, Yuxiang Weng, Jianwei Pan
Microplastics (MPs) have become a global concern due to their widespread environmental presence and human health risk, yet their risk on cerebrovascular diseases remains largely unexplored. In this case-control study, we collected cerebrospinal fluid samples from 48 intracranial aneurysms (IAs) patients and 108 leptomeningeal metastasis (LM) patients, and investigated the presence of MPs in these cerebrospinal fluid samples using pyrolysis-gas chromatography-mass spectrometry. Seven types of MPs were identified in the cerebrospinal fluid samples, among which polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polystyrene were present in over 80% of the samples. PE and PP were the most abundant MPs in cerebrospinal fluid samples. When using LM patients as controls, a significantly increased risk of IA was observed for subjects in the highest quartile of cerebrospinal fluid PP and PVC levels. Compared to the lowest quartile, the adjusted risk was elevated by 2.25-fold (95% CI: 1.68–5.94) and 3.82-fold (95% CI: 2.57–5.41) for PP and PVC levels, respectively. Our analysis revealed significant (p for trend < 0.01) dose-response relationships between cerebrospinal fluid MP mixture concentrations and IA risk. Bayesian kernel machine regression and quantile g-computation models further revealed synergistic effects of co-occurrence to MPs, with PVC contributing the strongest contribution (weight 55.8%). Our results suggest a potential link between higher cerebrospinal fluid levels of MPs and elevated IA risk, and highlight the need for further investigation into this emerging health risk.
微塑料(MPs)由于其广泛存在的环境和人类健康风险而成为全球关注的问题,但其对脑血管疾病的风险在很大程度上仍未被研究。在本病例对照研究中,我们收集了48例颅内动脉瘤(IAs)患者和108例脑脊液转移(LM)患者的脑脊液样本,并使用热解-气相色谱-质谱法研究了MPs在这些脑脊液样本中的存在。在脑脊液样品中鉴定出7种MPs,其中聚乙烯(PE)、聚丙烯(PP)、聚氯乙烯(PVC)和聚苯乙烯(聚苯乙烯)的含量超过80%。PE和PP是脑脊液中最丰富的MPs。当使用LM患者作为对照时,观察到脑脊液PP和PVC水平最高四分位数的受试者发生IA的风险显著增加。与最低四分位数相比,PP和PVC水平的调整风险分别增加了2.25倍(95% CI: 1.68-5.94)和3.82倍(95% CI: 2.57-5.41)。我们的分析显示脑脊液MP混合物浓度与IA风险之间存在显著的剂量-反应关系(p为趋势值<; 0.01)。贝叶斯核机回归和分位数g计算模型进一步揭示了共发生对MPs的协同效应,其中PVC贡献最大(权重55.8%)。我们的研究结果表明脑脊液MPs水平升高与IA风险升高之间存在潜在联系,并强调需要进一步调查这一新出现的健康风险。
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引用次数: 0
Development of HECAM Passive Samplers for Discovering the Occurrence, Sources, and Transport of Tire Additives and Their Transformation Products in Surface Waters 用于探测地表水中轮胎添加剂及其转化产物的发生、来源和迁移的HECAM被动采样器的研制
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127789
Ran Zhu, Yuchen Li, Xiaofan Yang, Xiaozhong Gao, Xiang Cheng
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引用次数: 0
Increased risks of systemic and abdominal obesity associated with long-term exposure to PM2.5 constituents 长期暴露于PM2.5成分中会增加全身和腹部肥胖的风险
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-06 DOI: 10.1016/j.envpol.2026.127777
Yang Yuan, Kai Wang, Yongqiang Liu, Yaqi Wang, Yunquan Zhang
Nexus between PM<sub>2.5</sub> constituents and obesity remain unclear, particular in densely populated and highly polluted regions. This study aims to assess the obese risk related to long-term exposure to PM<sub>2.5</sub> components among the Chinese elderly. We designed two nationwide dynamic cohort followed up from 2011 to 2015, through combining respondents from 28 provinces and estimates of PM<sub>2.5</sub> constituents predicted by well-validated spatiotemporal models. Based on data of physical examination measured by well-trained interviewers using standard devices, we adopted body mass index and waist circumference to define systemic and abdominal obesity, respectively. Cox proportional hazard models with time-varying exposures and a qg-computation approach were employed to evaluate individual and joint associations of obesity with long-term exposure to PM<sub>2.5</sub> constituents. The prevalences of systemic and abdominal obesity were 5.7% and 26.0% during 43814.6 and 27052.9 person-years follow-up, respectively. In the single-constituent analysis, the highest risk of systemic obesity derived from multivariable-adjusted model was 1.62 (95%: 1.40–1.87) linked with a 10.2 μg/m<sup>3</sup> increase of <span><span style=""></span><span data-mathml='<math xmlns="http://www.w3.org/1998/Math/MathML" />' role="presentation" style="font-size: 90%; display: inline-block; position: relative;" tabindex="0"><svg aria-hidden="true" focusable="false" height="0.24ex" role="img" style="vertical-align: -0.12ex;" viewbox="0 -51.7 0 103.4" width="0" xmlns:xlink="http://www.w3.org/1999/xlink"><g fill="currentColor" stroke="currentColor" stroke-width="0" transform="matrix(1 0 0 -1 0 0)"></g></svg><span role="presentation"><math xmlns="http://www.w3.org/1998/Math/MathML"></math></span></span><script type="math/mml"><math></math></script></span>, while the top-risk component of abdominal obesity was <span><span style=""></span><span data-mathml='<math xmlns="http://www.w3.org/1998/Math/MathML" />' role="presentation" style="font-size: 90%; display: inline-block; position: relative;" tabindex="0"><svg aria-hidden="true" focusable="false" height="0.24ex" role="img" style="vertical-align: -0.12ex;" viewbox="0 -51.7 0 103.4" width="0" xmlns:xlink="http://www.w3.org/1999/xlink"><g fill="currentColor" stroke="currentColor" stroke-width="0" transform="matrix(1 0 0 -1 0 0)"></g></svg><span role="presentation"><math xmlns="http://www.w3.org/1998/Math/MathML"></math></span></span><script type="math/mml"><math></math></script></span>, with a hazard ratio of 1.30 (95% CI: 1.20–1.41) for per 6.2 μg/m<sup>3</sup> rise. For joint exposure, a quartile increase in the five-component mixture was associated with a 29% (95% CI: 19–40%) and 17% (95% CI: 12–23%) higher risk of systemic and abdominal obesity, respectively. This study offered robust associations between long-term exposure to PM<sub>2.5</sub> constituents and increased risks of both obesity outcomes, sug
PM2.5成分与肥胖之间的关系尚不清楚,特别是在人口密集和污染严重的地区。本研究旨在评估中国老年人长期暴露于PM2.5成分的肥胖风险。我们设计了两个2011 - 2015年的全国动态队列,结合28个省份的受访者和经过验证的时空模型预测的PM2.5成分估计值。根据训练有素的采访者使用标准设备测量的体格检查数据,我们分别采用身体质量指数和腰围来定义全身性肥胖和腹部肥胖。采用时变暴露的Cox比例风险模型和qg计算方法来评估肥胖与长期暴露于PM2.5成分之间的个体和联合关联。在43814.6和27052.9人年的随访期间,全身性肥胖和腹部肥胖的患病率分别为5.7%和26.0%。在单成分分析中,多变量调整模型得出的系统性肥胖的最高风险为1.62(95%:1.40-1.87),与10.2 μg/m3的增加有关,而腹部肥胖的最高风险成分为1.30 (95% CI: 1.20-1.41),每增加6.2 μg/m3。对于关节暴露,五组分混合物的四分之一增加分别与29% (95% CI: 19-40%)和17% (95% CI: 12-23%)的系统性和腹部肥胖风险增加相关。这项研究提供了长期暴露于PM2.5成分与两种肥胖结果风险增加之间的强有力关联,表明减少空气污染可以降低肥胖负担。
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引用次数: 0
Widespread PFAS Contamination in Pet Food: Dietary Sources and Health Risks to Companion Animals 宠物食品中广泛存在的PFAS污染:食物来源和对伴侣动物的健康风险
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-06 DOI: 10.1016/j.envpol.2026.127779
Kei Nomiyama, Aika Sato, Rumi Tanoue, Kohei Saeki, Yoshinori Ikenaka, Hazuki Mizukawa
Despite the growing concern over per- and polyfluoroalkyl substances (PFAS) exposure in companion animals, dietary intake through commercial pet food remains poorly characterized. In this study, we conducted a comprehensive analysis of 100 commercially available pet food products for dogs and cats in Japan, encompassing both dry and wet types, to quantify 34 target PFAS compounds. PFAS were frequently detected, with concentrations varying by food type, ingredients, and country of origin. Fish-based products contained elevated levels of perfluorooctanesulfonic acid (PFOS), perfluoroundecanoic acid (PFUnDA), and perfluorotridecanoic acid (PFTrDA), and regional patterns suggested the influence of Asian-specific PFAS sources such as F-53B. Hazard quotient (HQ) assessments based on EFSA tolerable weekly intakes indicated that average HQs exceeded 1 for both dogs and cats in several products, signaling potential health risks. However, due to the lack of species-specific toxicokinetic information for dogs and cats, the EFSA-based risk characterization presented here should be interpreted as a preliminary assessment. Although dry food had higher PFAS concentrations when converted to feeding amounts, estimated exposure was higher for wet food due to higher consumption. These findings provide the first evidence of ingredient-driven and country-of-origin-dependent PFAS contamination in pet food. Fish used as ingredients are a significant source of exposure to PFAS. They also highlight the urgent need for regulatory oversight and toxicological evaluations specific to companion animals. These animals serve as vulnerable populations and as sentinels of human co-exposure in domestic environments.
尽管人们越来越关注伴侣动物的全氟和多氟烷基物质(PFAS)暴露,但通过商业宠物食品摄入的饮食特征仍然很差。在这项研究中,我们对日本100种市售的猫狗宠物食品进行了全面分析,包括干型和湿型,以量化34种目标PFAS化合物。PFAS经常被检测到,其浓度因食品类型、成分和原产国而异。鱼类产品中全氟辛烷磺酸(PFOS)、全氟癸酸(PFUnDA)和全氟三烷酸(PFTrDA)的含量较高,区域模式表明亚洲特有的全氟辛烷磺酸来源(如F-53B)的影响。基于欧洲食品安全局每周可容忍摄入量的危害商数(HQ)评估表明,在一些产品中,狗和猫的平均HQ均超过1,表明存在潜在的健康风险。然而,由于缺乏狗和猫的物种特异性毒性动力学信息,本文提出的基于欧洲食品安全局的风险表征应被解释为初步评估。虽然干粮在转化为饲料量时含有较高的PFAS浓度,但由于消费量较高,湿粮的估计暴露量较高。这些发现提供了宠物食品中全氟辛烷磺酸污染由成分驱动和原产国决定的第一个证据。用作原料的鱼是接触PFAS的重要来源。他们还强调了对伴侣动物进行监管和毒理学评估的迫切需要。这些动物是脆弱的种群,也是人类在家庭环境中共同暴露的哨兵。
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引用次数: 0
Insights from Over a Million Births on Maternal Exposure to Multiple Pollutants and the Risk of Isolated Ventricular Septal Defects 100多万新生儿对母亲暴露于多种污染物和孤立性室间隔缺陷风险的见解
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-05 DOI: 10.1016/j.envpol.2026.127736
Xuelian Yuan, Li Dai, Ke Wang, Qi Li, Zhen Liu, Wenyan Li, Wenli Xu, Zhiyu Chen, Yuyang Gao, Jun Zhu, Hanmin Liu, Xiaohong Li
Numerous research works have established connections between maternal exposure to specific air pollutants and ventricular septal defects (VSD), there are still gaps in understanding the complexities of combined exposures in real-world settings. This study seeks to investigate the correlation between simultaneous exposure to five air pollutants throughout pregnancy and the likelihood of isolated VSD occurrence. It aims to address the gap between research focusing on individual pollutants and the complexities of real-world exposure scenarios. Utilizing data from China's National Population-Based Birth Defects Surveillance Network, we analyzed 850 isolated VSD cases against 1,097,056 unaffected births. Using a random forest land use regression model, we estimated daily pollutant concentrations (SO2, NO2, CO, O3, PM2.5) at geocoded maternal residences from 2014 to 2017. Based on these daily estimates, trimester-specific exposure concentrations were derived using dates of pregnancy onset and gestational weeks. Additionally, we devised an "air pollution score" to evaluate their cumulative exposure. The risk of isolated VSDs rose significantly with every 10-μg/m3 increase in air pollution score during pregnancy, especially the first trimester (OR 1.023, 95% CI 1.011-1.035), and the third trimester (OR 1.015, 95% CI 1.003-1.026). A linear relationship was observed between levels of air pollution scores during the entire pregnancy and the risk of isolated VSDs. The heightened risk linked to air pollution score during the first trimester surpassed that of the second and third trimesters. Besides, the results highlighted a pronounced risk among mothers in rural, low-income areas and being pregnant in cold season. By providing a more comprehensive assessment of the potential risks that pollutants pose to maternal and infant health, this study may offer important insights for public health policy and inform the development of new clinical tools for risk assessment and early screening.
许多研究工作已经建立了母亲暴露于特定空气污染物和室间隔缺陷(VSD)之间的联系,但在了解现实环境中联合暴露的复杂性方面仍然存在差距。本研究旨在探讨在怀孕期间同时暴露于五种空气污染物与孤立性室间隔发育的可能性之间的关系。它旨在解决关注单个污染物的研究与现实世界暴露情景的复杂性之间的差距。利用中国全国人口出生缺陷监测网的数据,我们分析了850例孤立的室性室间隔缺损病例和1,097,056例未受影响的新生儿。利用随机林地利用回归模型,我们估算了2014年至2017年地理编码的孕产妇居住地的日污染物浓度(SO2、NO2、CO、O3和PM2.5)。基于这些每日估计,根据妊娠开始日期和妊娠周得出妊娠期特异性暴露浓度。此外,我们设计了一个“空气污染评分”来评估他们的累积暴露。妊娠期空气污染评分每增加10 μg/m3,尤其是妊娠前期(OR 1.023, 95% CI 1.011 ~ 1.035)和妊娠晚期(OR 1.015, 95% CI 1.003 ~ 1.026),分离性VSDs的发生风险显著增加。在整个怀孕期间的空气污染评分水平与孤立性室性心脏疾病的风险之间观察到线性关系。怀孕前三个月与空气污染得分相关的风险增加程度超过了妊娠中期和晚期。此外,研究结果还强调了农村、低收入地区的母亲在寒冷季节怀孕的明显风险。通过对污染物对母婴健康构成的潜在风险进行更全面的评估,本研究可能为公共卫生政策提供重要见解,并为风险评估和早期筛查的新临床工具的开发提供信息。
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引用次数: 0
Ionic PFAS in PM2.5 and Dust: Insights on Indoor-Outdoor Profiles and Distribution PM2.5和粉尘中的离子PFAS:室内室外分布和分布的见解
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-05 DOI: 10.1016/j.envpol.2026.127767
Junqi Li, Yulong Ma, Yanli Li, Cuiping Jia, Ying Xiong, Bo Zhang, Stuart Harrad, Ke Du
Although extensive studies have been performed to characterize Per- and polyfluoroalkyl substances (PFAS) in the environment, PFAS in PM2.5 remains underexplored. This study presents a comprehensive investigation of PFAS in indoor and outdoor PM2.5 and dust samples to evaluate their quantities and distribution. Twenty-nine ionic PFAS species were quantified in samples collected from ten different environments such as daycare center, vehicle, airport, and fire training facility. PFAS were found to be ubiquitous, and present in both PM2.5 (3.34–22.2 pg/m3) and dust (1.27–9840 ng/g). Perfluoroalkyl carboxylic acids (PFCAs) dominated the PFAS profile in both indoor and outdoor PM2.5, accounting for 94.1 ± 11.1% of total PFAS, which was significantly higher than that in dust (61.5 ± 32.7%) (p < 0.01). In contrast, the proportion of perfluoroalkane sulfonic acids (PFSAs) in dust (21.7 ± 18.1%) was significantly higher than that in PM2.5 (4.54 ± 10.5%) (p < 0.01). This suggests that PFCAs are more likely than PFSAs to attach to PM2.5, and are capable of long-range atmospheric transport (LRT). Among the 11 PFCAs species, perfluorobutanoic acid (PFBA) and perfluorohexanoic acid (PFHxA), two short chain PFAS, were of the highest concentrations, particularly in samples collected during the wildfire events. This highlights the significance of short chain PFAS in LRT. For indoor PFAS, a strong relationship (r = 0.611–0.853, p < 0.01) was observed between long-chain PFCAs concentrations in PM2.5 and in dust. These findings provide new insights into the potential processes of indoor PFCAs emissions and distribution and suggest possible exposure pathways of airborne PFAS in urban environments.
尽管对环境中的全氟烷基和多氟烷基物质(PFAS)进行了广泛的研究,但对PM2.5中的PFAS的研究仍然不足。本研究对室内和室外PM2.5和粉尘样品中的PFAS进行了全面调查,以评估其数量和分布。在日托中心、车辆、机场和消防训练设施等10种不同环境中采集了29种离子PFAS。PFAS普遍存在于PM2.5 (3.34-22.2 pg/m3)和粉尘(1.27-9840 ng/g)中。全氟烷基羧酸(PFCAs)在室内外PM2.5中均占主导地位,占总PFAS的94.1±11.1%,显著高于粉尘(61.5±32.7%)(p < 0.01)。全氟烷烃磺酸(PFSAs)在粉尘中的比例(21.7±18.1%)显著高于PM2.5(4.54±10.5%)(p < 0.01)。这表明PFCAs比pfsa更有可能附着在PM2.5上,并且能够进行远距离大气输送(LRT)。在11种PFCAs中,全氟丁酸(PFBA)和全氟己酸(PFHxA)这两种短链PFAS的浓度最高,特别是在野火事件期间收集的样品中。这凸显了短链PFAS在LRT中的重要性。对于室内PFAS, PM2.5中长链PFCAs浓度与粉尘中存在较强的相关性(r = 0.611-0.853, p < 0.01)。这些发现为了解室内PFAS排放和分布的潜在过程提供了新的见解,并提出了城市环境中空气中PFAS的可能暴露途径。
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引用次数: 0
Artificial Light at Night Disrupts Immune Rhythms in Wild Rodents under Semi-Natural Conditions 夜间人造光在半自然条件下扰乱野生啮齿动物的免疫节律
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-05 DOI: 10.1016/j.envpol.2026.127774
Hagar Vardi-Naim, Gul Janovsky, Noga Kronfeld-Schor, Yariv Wine
Artificial light at night (ALAN) is a rapidly expanding form of environmental pollution that disrupts natural light–dark cycles and alters behavioral and physiological rhythms across species. Because immune function is tightly linked to environmental cues, studying ALAN within an ecoimmunological framework is essential for understanding its real-world impacts on wildlife fitness. In natural settings, immune rhythms are shaped by multiple, interacting environmental pressures, and evaluating ALAN against this broader ecological backdrop is critical for interpreting its physiological consequences.We investigated how low-intensity ALAN affects immune and endocrine rhythmicity, antibody responses, and survival in two wild rodent species with opposing activity patterns, the nocturnal <em>Acomys dimidiatus</em> and the diurnal <em>Acomys russatus</em>, maintained in semi-natural outdoor enclosures. Under natural light-dark conditions, both species exhibited daily oscillations in circulating lymphocyte frequencies, and in <em>A. dimidiatus</em>, fecal cortisol also showed a clear daily rhythm. These rhythms were disrupted or dampened under ALAN. Moreover, antibody titers were significantly higher when immunization occurred during the species-specific rest phase, but ALAN exposure disrupted these rhythms, eliminating time-of-day variation in antibody responses. Overall, ALAN increased the mortality risk by 2.35-fold.Although controlled laboratory experiments have been essential for advancing immunology, they offer limited insight into how environmental disturbances like light pollution affect wildlife under realistic conditions. By studying wild rodents in semi-natural habitats, we reveal that ALAN exposure alters immune rhythms, endocrine patterns, and survival in ways that emerge only when animals experience natural ecological variation. These results highlight that immune baselines in the wild are products of complex environmental interactions and that ALAN can disrupt these integrated physiological systems. Together, these findings underscore the need for ecoimmunological approaches to assess how expanding light pollution threatens wildlife health and resilience.Significance StatementArtificial light at night (ALAN) is a growing anthropogenic disturbance with wide-ranging ecological and physiological impacts. While its disruptive effect on circadian rhythms is well documented, its effects on immune function remain underexplored. Our findings show that ALAN alters immune rhythmicity and weakens time-dependent antibody responses in wild rodents under semi-natural conditions, potentially increasing susceptibility to infection. Studying the effects of light pollution on wild species under natural conditions is essential not only for understanding its impact on ecosystem health, but also for assessing how altered immune function may influence the emergence and spread of zoonotic diseases. These insights underscore the need to investigate immunity in ecolog
夜间人造光(ALAN)是一种迅速扩大的环境污染形式,它破坏了自然的光暗循环,改变了物种的行为和生理节律。由于免疫功能与环境因素密切相关,因此在生态免疫学框架内研究ALAN对于理解其对野生动物适应性的现实影响至关重要。在自然环境中,免疫节律是由多种相互作用的环境压力形成的,在这种更广泛的生态背景下评估ALAN对于解释其生理后果至关重要。我们研究了低强度ALAN如何影响两种活动模式相反的野生啮齿动物的免疫和内分泌节律、抗体反应和存活率,这两种啮齿动物分别是夜间活动的侏儒和白天活动的侏儒,饲养在半自然的室外围栏中。在自然光照-黑暗条件下,这两种物种的循环淋巴细胞频率均表现出日振荡,而在a . dimidiatus中,粪便皮质醇也表现出明显的日节律。在ALAN的作用下,这些节律被打乱或减弱了。此外,当免疫发生在物种特异性休息阶段时,抗体滴度显着较高,但ALAN暴露破坏了这些节律,消除了抗体反应的时间变化。总的来说,ALAN使死亡风险增加了2.35倍。尽管受控的实验室实验对于推进免疫学至关重要,但它们对光污染等环境干扰如何在现实条件下影响野生动物提供的见解有限。通过研究半自然栖息地的野生啮齿动物,我们发现ALAN暴露会以只有在动物经历自然生态变化时才会出现的方式改变免疫节律、内分泌模式和生存。这些结果表明,野外的免疫基线是复杂环境相互作用的产物,ALAN可以破坏这些综合生理系统。总之,这些发现强调了生态免疫学方法的必要性,以评估不断扩大的光污染如何威胁野生动物的健康和恢复能力。意义声明:夜间人造光(ALAN)是一种日益增长的具有广泛生态和生理影响的人为干扰。虽然其对昼夜节律的破坏性影响已被充分记录,但其对免疫功能的影响仍未得到充分探讨。我们的研究结果表明,在半自然条件下,ALAN改变了野生啮齿动物的免疫节律,削弱了时间依赖性抗体反应,可能增加了对感染的易感性。研究自然条件下光污染对野生物种的影响不仅对了解其对生态系统健康的影响至关重要,而且对于评估免疫功能的改变如何影响人畜共患疾病的出现和传播至关重要。这些见解强调了在传统实验室模型和条件之外,在生态相关背景下调查免疫的必要性。
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Environmental Pollution
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