首页 > 最新文献

Environmental Pollution最新文献

英文 中文
PFAS concentrations and compositional profiles in great tit (Parus major) feathers, faecal samples and blood plasma: Implications for non-invasive monitoring 大山雀(Parus major)羽毛、粪便样本和血浆中PFAS的浓度和组成特征:对非侵入性监测的意义
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127783
Jodie Buytaert, Marcel Eens, Lieven Bervoets, Oliver Salangad, Adrian Covaci, Thimo Groffen
{"title":"PFAS concentrations and compositional profiles in great tit (Parus major) feathers, faecal samples and blood plasma: Implications for non-invasive monitoring","authors":"Jodie Buytaert, Marcel Eens, Lieven Bervoets, Oliver Salangad, Adrian Covaci, Thimo Groffen","doi":"10.1016/j.envpol.2026.127783","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127783","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"9 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic phosphate flame retardants exposure and neuroaxonal injury in adults: a systematic study integrating human data and network toxicology 有机磷酸盐阻燃剂暴露与成人神经轴突损伤:一项整合人类数据和网络毒理学的系统研究
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127780
Lingxu Kong, Xinlu Miao, Xiaoxuan Qiu, Hao Wei, Xiaojie Xu, Bo Tan, Qian Sun, Hui Gao, Tao Xia, Shun Zhang
{"title":"Organic phosphate flame retardants exposure and neuroaxonal injury in adults: a systematic study integrating human data and network toxicology","authors":"Lingxu Kong, Xinlu Miao, Xiaoxuan Qiu, Hao Wei, Xiaojie Xu, Bo Tan, Qian Sun, Hui Gao, Tao Xia, Shun Zhang","doi":"10.1016/j.envpol.2026.127780","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127780","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"91 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Source-driven vertical partitioning and stratified risk assessment of trace metals in a subtropical forest soil profile 亚热带森林土壤剖面中痕量金属源驱动垂直分区及分层风险评价
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127784
Juan Li, Tiantian Li, Wenrui Zhao, Xin Sun, Xun Liu, Shuai Liu, Chuansheng Wu
{"title":"Source-driven vertical partitioning and stratified risk assessment of trace metals in a subtropical forest soil profile","authors":"Juan Li, Tiantian Li, Wenrui Zhao, Xin Sun, Xun Liu, Shuai Liu, Chuansheng Wu","doi":"10.1016/j.envpol.2026.127784","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127784","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"92 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PFAS exposure of juvenile loggerhead turtles (Caretta caretta) from the Western Mediterranean Sea to 36 PFAS and its association with oxidative stress. 西地中海幼海龟(Caretta Caretta)对36种PFAS的暴露及其与氧化应激的关系
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127769
Olga Novillo-Sanjuan, Shannen Thora Lea Sait, Junjie Zhang, Susana V. Gonzalez, Juan Antonio Raga, Jesús Tomás Aguirre, Alexandros G. Asimakopoulos
{"title":"PFAS exposure of juvenile loggerhead turtles (Caretta caretta) from the Western Mediterranean Sea to 36 PFAS and its association with oxidative stress.","authors":"Olga Novillo-Sanjuan, Shannen Thora Lea Sait, Junjie Zhang, Susana V. Gonzalez, Juan Antonio Raga, Jesús Tomás Aguirre, Alexandros G. Asimakopoulos","doi":"10.1016/j.envpol.2026.127769","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127769","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"19 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of Complex Environmental Contaminant Mixtures in Common Toad Breeding Ponds in Flanders, Belgium 比利时法兰德斯常见蟾蜍养殖池塘中复杂环境污染物混合物的特征
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127785
S. Devliegere, T. Goessens, S. De Baere, E. Blomme, A. Barbi, E. Meers, L. Vanhaecke, P. Spanoghe, A. Martel, F. Batsleer, D. Bonte, F. Pasmans, S. Croubels
The European common toad (Bufo bufo) is undergoing widespread population declines, potentially influenced by multiple environmental stressors, including chemical pollution. This study aimed to link the toad population status and contaminant levels in 20 breeding ponds in Flanders (Belgium). A multi-contaminant analytical approach was applied, using solid-phase extraction (SPE) combined with advanced instrumental methods: ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) for pesticides and mycotoxins, UHPLC-Orbitrap-high resolution MS for pharmaceuticals, inductively coupled plasma-optical emission spectrometry (ICP-OES) and ICP-MS for high and low-concentrated metals, respectively, and ion chromatography (IC) for nutrients. Across ponds, 25 pesticides, 11 mycotoxins, 13 antimicrobial drugs, 5 antiparasitic drugs, and 11 metals were detected, reaching concentrations up to 114 ng/L (pesticides), 88.2 ng/L (mycotoxins), 837 ng/L (antimicrobials), 26.8 ng/L (antiparasitic drugs), and 7382 μg/L (metals). Temporal variability was pronounced, with episodic increases in pesticide and metal levels, declining nitrate and sulphate concentrations, and increasing enniatin levels from March to June. Despite frequent co-contamination, no direct relationship was observed between individual contaminant levels and toad population status. These findings suggest that population declines are unlikely to be driven by a single substance, but rather by combined pressures associated with complex contaminant mixtures and other environmental stressors.
欧洲蟾蜍(Bufo Bufo)正在经历广泛的数量下降,可能受到多种环境压力因素的影响,包括化学污染。本研究旨在了解比利时法兰德斯20个养殖池塘中蟾蜍种群状况与污染物水平的关系。采用固相萃取(SPE)结合先进的仪器分析方法,对农药和真菌毒素进行了超高效液相色谱-串联质谱分析(UHPLC-MS /MS),对药物进行了超高效液相色谱-高分辨率质谱分析(uhplc - orbitrap -高分辨率质谱分析),对高、低浓度金属分别进行了电感耦合等离子体光学发射光谱分析(ICP-OES)和ICP-MS分析,对营养物质进行了离子色谱分析(IC)。共检出25种农药、11种真菌毒素、13种抗菌药物、5种抗寄生虫药物和11种金属,浓度分别为114 ng/L(农药)、88.2 ng/L(真菌毒素)、837 ng/L(抗菌药物)、26.8 ng/L(抗寄生虫药物)和7382 μg/L(金属)。从3月到6月,时间变化明显,农药和金属含量断断续续地增加,硝酸盐和硫酸盐浓度下降,enniatin含量增加。尽管经常发生共同污染,但没有观察到单个污染物水平与蟾蜍种群状况之间的直接关系。这些发现表明,数量下降不太可能是由单一物质驱动的,而是由复杂污染物混合物和其他环境压力因素相关的综合压力驱动的。
{"title":"Characterization of Complex Environmental Contaminant Mixtures in Common Toad Breeding Ponds in Flanders, Belgium","authors":"S. Devliegere, T. Goessens, S. De Baere, E. Blomme, A. Barbi, E. Meers, L. Vanhaecke, P. Spanoghe, A. Martel, F. Batsleer, D. Bonte, F. Pasmans, S. Croubels","doi":"10.1016/j.envpol.2026.127785","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127785","url":null,"abstract":"The European common toad (<em>Bufo bufo</em>) is undergoing widespread population declines, potentially influenced by multiple environmental stressors, including chemical pollution. This study aimed to link the toad population status and contaminant levels in 20 breeding ponds in Flanders (Belgium). A multi-contaminant analytical approach was applied, using solid-phase extraction (SPE) combined with advanced instrumental methods: ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) for pesticides and mycotoxins, UHPLC-Orbitrap-high resolution MS for pharmaceuticals, inductively coupled plasma-optical emission spectrometry (ICP-OES) and ICP-MS for high and low-concentrated metals, respectively, and ion chromatography (IC) for nutrients. Across ponds, 25 pesticides, 11 mycotoxins, 13 antimicrobial drugs, 5 antiparasitic drugs, and 11 metals were detected, reaching concentrations up to 114 ng/L (pesticides), 88.2 ng/L (mycotoxins), 837 ng/L (antimicrobials), 26.8 ng/L (antiparasitic drugs), and 7382 μg/L (metals). Temporal variability was pronounced, with episodic increases in pesticide and metal levels, declining nitrate and sulphate concentrations, and increasing enniatin levels from March to June. Despite frequent co-contamination, no direct relationship was observed between individual contaminant levels and toad population status. These findings suggest that population declines are unlikely to be driven by a single substance, but rather by combined pressures associated with complex contaminant mixtures and other environmental stressors.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"293 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyethylene and polylactic acid microplastics affect the migration of Cr(VI) and Cr(III) in acidic clay soil via distinct mechanisms 聚乙烯和聚乳酸微塑料通过不同的机制影响Cr(VI)和Cr(III)在酸性粘土中的迁移
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127781
Weiming Feng, Gongwei Xu, Xinru Zhai, Libing Zheng, Helian Li
The coexistence of microplastics (MPs) and heavy metals in agricultural soils leads to complex interactions during their adsorption and migration processes. Understanding their fate under realistic soil conditions is crucial for assessing the associated environmental risks. Therefore, virgin and aged polyethylene (PE) and polylactic acid (PLA) MPs were used to investigate their influence on the adsorption and migration of chromium (Cr) in unsaturated steady-state soils via batch and column experiments. Batch experiments revealed that soil adsorbed less Cr(VI) than Cr(III) (0.44 vs. 1.45 mg/g). The addition of MPs inhibited Cr adsorption (specifically, 0.40 and 1.23 mg/g for Cr(VI) and Cr(III), respectively, at 7% MP addition), with adsorption capacity decreasing as MP dosage increased. Column experiments showed Cr(VI) reached adsorption equilibrium faster than Cr(III) (25 vs. 41 pore volumes); its migration was primarily controlled by soil hydraulic conditions, and MPs exerted an inhibitory effect. In contrast, Cr(III) migration was predominantly governed by adsorption, and MP addition promoted its migration. Regarding the MPs themselves, PE exhibits greater migration capacity, which decreased with aging, whereas PLA showed the opposite trend. Interestingly, the presence of Cr(III) reduces the migration of MPs compared to Cr(VI). These findings clarify the effects and mechanisms of MPs on Cr migration under realistic soil conditions, and enhance the understanding of migration dynamics and environmental fate of coexisting pollutants.
微塑料与重金属在农业土壤中的共存,导致它们在吸附和迁移过程中发生复杂的相互作用。了解它们在现实土壤条件下的命运对于评估相关的环境风险至关重要。因此,采用未加工聚乙烯(PE)和陈化聚乙烯(PLA) MPs,通过批量和柱状实验研究了它们对非饱和稳态土壤中铬(Cr)的吸附和迁移的影响。批量试验结果表明,土壤对Cr(VI)的吸附量小于Cr(III) (0.44 vs. 1.45 mg/g)。MP的加入抑制了Cr的吸附(在MP添加量为7%时,Cr(VI)和Cr(III)的吸附量分别为0.40和1.23 mg/g),吸附量随MP添加量的增加而降低。柱实验表明,Cr(VI)比Cr(III)更快达到吸附平衡(25比41孔体积);其迁移主要受土壤水力条件控制,MPs具有抑制作用。相反,Cr(III)的迁移主要受吸附控制,MP的加入促进了其迁移。就MPs本身而言,PE表现出更大的迁移能力,随着年龄的增长而下降,而PLA表现出相反的趋势。有趣的是,与Cr(VI)相比,Cr(III)的存在减少了MPs的迁移。这些发现阐明了实际土壤条件下MPs对Cr迁移的影响及其机制,增强了对共存污染物迁移动力学和环境命运的认识。
{"title":"Polyethylene and polylactic acid microplastics affect the migration of Cr(VI) and Cr(III) in acidic clay soil via distinct mechanisms","authors":"Weiming Feng, Gongwei Xu, Xinru Zhai, Libing Zheng, Helian Li","doi":"10.1016/j.envpol.2026.127781","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127781","url":null,"abstract":"The coexistence of microplastics (MPs) and heavy metals in agricultural soils leads to complex interactions during their adsorption and migration processes. Understanding their fate under realistic soil conditions is crucial for assessing the associated environmental risks. Therefore, virgin and aged polyethylene (PE) and polylactic acid (PLA) MPs were used to investigate their influence on the adsorption and migration of chromium (Cr) in unsaturated steady-state soils via batch and column experiments. Batch experiments revealed that soil adsorbed less Cr(VI) than Cr(III) (0.44 vs. 1.45 mg/g). The addition of MPs inhibited Cr adsorption (specifically, 0.40 and 1.23 mg/g for Cr(VI) and Cr(III), respectively, at 7% MP addition), with adsorption capacity decreasing as MP dosage increased. Column experiments showed Cr(VI) reached adsorption equilibrium faster than Cr(III) (25 vs. 41 pore volumes); its migration was primarily controlled by soil hydraulic conditions, and MPs exerted an inhibitory effect. In contrast, Cr(III) migration was predominantly governed by adsorption, and MP addition promoted its migration. Regarding the MPs themselves, PE exhibits greater migration capacity, which decreased with aging, whereas PLA showed the opposite trend. Interestingly, the presence of Cr(III) reduces the migration of MPs compared to Cr(VI). These findings clarify the effects and mechanisms of MPs on Cr migration under realistic soil conditions, and enhance the understanding of migration dynamics and environmental fate of coexisting pollutants.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"235 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to ‘Comparative evaluation of surface-level PM2.5 modeling across Northeast Asia: relevance for regulatory and scientific applications’ [Environ. Pollut. 377 (2025) 126428] 《东北亚地区地表PM2.5模型的比较评估:与监管和科学应用的相关性》的勘误表[environment]。污染。377 (2025)126428]
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127771
Hyeon-Kook Kim, EunRyoung Kim, Chang-Keun Song, Jae-Ho Choi, Ganghan Kim, Myong-In Lee, Yujin J. Oak, Rokjin J. Park, Ilhan Ryoo, Seung-Muk Yi, Kyung-Mi Lee, Hyeok-Gi Cheo, Kwon-Ho Jeon
{"title":"Corrigendum to ‘Comparative evaluation of surface-level PM2.5 modeling across Northeast Asia: relevance for regulatory and scientific applications’ [Environ. Pollut. 377 (2025) 126428]","authors":"Hyeon-Kook Kim, EunRyoung Kim, Chang-Keun Song, Jae-Ho Choi, Ganghan Kim, Myong-In Lee, Yujin J. Oak, Rokjin J. Park, Ilhan Ryoo, Seung-Muk Yi, Kyung-Mi Lee, Hyeok-Gi Cheo, Kwon-Ho Jeon","doi":"10.1016/j.envpol.2026.127771","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127771","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"34 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioaccumulation, trophic transfer, and health risk assessment of microplastics in the food web of Wuliangsuhai Lake, China: Higher risk for children 中国五粮素海食物网中微塑料的生物积累、营养转移和健康风险评估:对儿童的高风险
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127787
Guoliang Zhang, Jinhui Sun, Yiran Zhan, Bowen Xiao, Huamin Liu, Lixin Wang
{"title":"Bioaccumulation, trophic transfer, and health risk assessment of microplastics in the food web of Wuliangsuhai Lake, China: Higher risk for children","authors":"Guoliang Zhang, Jinhui Sun, Yiran Zhan, Bowen Xiao, Huamin Liu, Lixin Wang","doi":"10.1016/j.envpol.2026.127787","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127787","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"182 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polylactic acid microplastic exposure induced male reproductive toxicity and decreased testosterone levels by accelerating Leydig cell senescence 聚乳酸微塑料暴露通过加速间质细胞衰老诱导雄性生殖毒性和降低睾丸激素水平
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127778
Zhencheng Fan, Xinglong Wang, Yunqi Wu, Shuhao Li, Liang Kong, Shoujun Li, Tan Ma, Chun Pan
Polylactic acid microplastics (PLA-MPs), despite being marketed as biodegradable and eco-friendly alternatives to conventional plastics, have raised growing concerns regarding their potential adverse effects on human health. The reproductive toxicity of PLA-MPs exposure in male mammals has been confirmed in previous studies, but its specific effects on testosterone biosynthesis remain unclear. Male mice were treated with PLA-MPs at doses of low, medium, and high (0.01, 0.1, and 1 mg/d, respectively) for a duration of 28 days in this study. Our results demonstrated that PLA-MPs were enriched in mouse testes and led to a dose-dependent decrease in the serum testosterone concentration. We also observed the accumulation of senescent Leydig cells in the testis, along with inhibited autophagy and mitophagy. Moreover, we identified the critical involvement of autophagy and mitophagy in PLA-MPs-induced Leydig cell senescence. Re-establishment of autophagy and mitophagy effectively reserved the senescence of Leydig cell. Overall, our study revealed that PLA-MPs inhibit autophagy and mitophagy, thereby promoting Leydig cell senescence and subsequently reducing testosterone synthesis and secretion. These results advance our understanding of the pathogenic mechanisms underlying PLA-MPs-induced reproductive toxicity in male mammals.
聚乳酸微塑料(PLA-MPs)尽管被标榜为传统塑料的可生物降解和环保替代品,但其对人体健康的潜在不利影响引起了越来越多的关注。先前的研究已证实雄性哺乳动物暴露于PLA-MPs的生殖毒性,但其对睾酮生物合成的具体影响尚不清楚。在本研究中,雄性小鼠以低、中、高剂量(分别为0.01、0.1和1mg /d)的PLA-MPs治疗28天。我们的研究结果表明,PLA-MPs在小鼠睾丸中富集,并导致血清睾酮浓度呈剂量依赖性下降。我们还观察到睾丸中衰老的间质细胞的积累,同时自噬和有丝自噬受到抑制。此外,我们确定了自噬和有丝自噬在pla - mps诱导的间质细胞衰老中的关键作用。自噬和有丝自噬的重建有效地延缓了间质细胞的衰老。总的来说,我们的研究表明PLA-MPs抑制自噬和有丝分裂,从而促进间质细胞衰老,从而减少睾酮的合成和分泌。这些结果促进了我们对pla - mps诱导雄性哺乳动物生殖毒性的致病机制的理解。
{"title":"Polylactic acid microplastic exposure induced male reproductive toxicity and decreased testosterone levels by accelerating Leydig cell senescence","authors":"Zhencheng Fan, Xinglong Wang, Yunqi Wu, Shuhao Li, Liang Kong, Shoujun Li, Tan Ma, Chun Pan","doi":"10.1016/j.envpol.2026.127778","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127778","url":null,"abstract":"Polylactic acid microplastics (PLA-MPs), despite being marketed as biodegradable and eco-friendly alternatives to conventional plastics, have raised growing concerns regarding their potential adverse effects on human health. The reproductive toxicity of PLA-MPs exposure in male mammals has been confirmed in previous studies, but its specific effects on testosterone biosynthesis remain unclear. Male mice were treated with PLA-MPs at doses of low, medium, and high (0.01, 0.1, and 1 mg/d, respectively) for a duration of 28 days in this study. Our results demonstrated that PLA-MPs were enriched in mouse testes and led to a dose-dependent decrease in the serum testosterone concentration. We also observed the accumulation of senescent Leydig cells in the testis, along with inhibited autophagy and mitophagy. Moreover, we identified the critical involvement of autophagy and mitophagy in PLA-MPs-induced Leydig cell senescence. Re-establishment of autophagy and mitophagy effectively reserved the senescence of Leydig cell. Overall, our study revealed that PLA-MPs inhibit autophagy and mitophagy, thereby promoting Leydig cell senescence and subsequently reducing testosterone synthesis and secretion. These results advance our understanding of the pathogenic mechanisms underlying PLA-MPs-induced reproductive toxicity in male mammals.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"74 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case-Control Study Linking Concentrations of Microplastics in Human Cerebrospinal Fluid to Intracranial Aneurysm Risk 人脑脊液中微塑料浓度与颅内动脉瘤风险的病例对照研究
IF 8.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envpol.2026.127788
Zebin Fang, Xiaoyi Wang, Fan Wu, Sihan Mao, Hao Jiang, Chi Hu, Luyuan Zhang, Weijian Fan, Chao Zhang, Ping Lan, Kaiyuan Huang, Yuxiang Weng, Jianwei Pan
Microplastics (MPs) have become a global concern due to their widespread environmental presence and human health risk, yet their risk on cerebrovascular diseases remains largely unexplored. In this case-control study, we collected cerebrospinal fluid samples from 48 intracranial aneurysms (IAs) patients and 108 leptomeningeal metastasis (LM) patients, and investigated the presence of MPs in these cerebrospinal fluid samples using pyrolysis-gas chromatography-mass spectrometry. Seven types of MPs were identified in the cerebrospinal fluid samples, among which polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polystyrene were present in over 80% of the samples. PE and PP were the most abundant MPs in cerebrospinal fluid samples. When using LM patients as controls, a significantly increased risk of IA was observed for subjects in the highest quartile of cerebrospinal fluid PP and PVC levels. Compared to the lowest quartile, the adjusted risk was elevated by 2.25-fold (95% CI: 1.68–5.94) and 3.82-fold (95% CI: 2.57–5.41) for PP and PVC levels, respectively. Our analysis revealed significant (p for trend < 0.01) dose-response relationships between cerebrospinal fluid MP mixture concentrations and IA risk. Bayesian kernel machine regression and quantile g-computation models further revealed synergistic effects of co-occurrence to MPs, with PVC contributing the strongest contribution (weight 55.8%). Our results suggest a potential link between higher cerebrospinal fluid levels of MPs and elevated IA risk, and highlight the need for further investigation into this emerging health risk.
微塑料(MPs)由于其广泛存在的环境和人类健康风险而成为全球关注的问题,但其对脑血管疾病的风险在很大程度上仍未被研究。在本病例对照研究中,我们收集了48例颅内动脉瘤(IAs)患者和108例脑脊液转移(LM)患者的脑脊液样本,并使用热解-气相色谱-质谱法研究了MPs在这些脑脊液样本中的存在。在脑脊液样品中鉴定出7种MPs,其中聚乙烯(PE)、聚丙烯(PP)、聚氯乙烯(PVC)和聚苯乙烯(聚苯乙烯)的含量超过80%。PE和PP是脑脊液中最丰富的MPs。当使用LM患者作为对照时,观察到脑脊液PP和PVC水平最高四分位数的受试者发生IA的风险显著增加。与最低四分位数相比,PP和PVC水平的调整风险分别增加了2.25倍(95% CI: 1.68-5.94)和3.82倍(95% CI: 2.57-5.41)。我们的分析显示脑脊液MP混合物浓度与IA风险之间存在显著的剂量-反应关系(p为趋势值<; 0.01)。贝叶斯核机回归和分位数g计算模型进一步揭示了共发生对MPs的协同效应,其中PVC贡献最大(权重55.8%)。我们的研究结果表明脑脊液MPs水平升高与IA风险升高之间存在潜在联系,并强调需要进一步调查这一新出现的健康风险。
{"title":"A Case-Control Study Linking Concentrations of Microplastics in Human Cerebrospinal Fluid to Intracranial Aneurysm Risk","authors":"Zebin Fang, Xiaoyi Wang, Fan Wu, Sihan Mao, Hao Jiang, Chi Hu, Luyuan Zhang, Weijian Fan, Chao Zhang, Ping Lan, Kaiyuan Huang, Yuxiang Weng, Jianwei Pan","doi":"10.1016/j.envpol.2026.127788","DOIUrl":"https://doi.org/10.1016/j.envpol.2026.127788","url":null,"abstract":"Microplastics (MPs) have become a global concern due to their widespread environmental presence and human health risk, yet their risk on cerebrovascular diseases remains largely unexplored. In this case-control study, we collected cerebrospinal fluid samples from 48 intracranial aneurysms (IAs) patients and 108 leptomeningeal metastasis (LM) patients, and investigated the presence of MPs in these cerebrospinal fluid samples using pyrolysis-gas chromatography-mass spectrometry. Seven types of MPs were identified in the cerebrospinal fluid samples, among which polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polystyrene were present in over 80% of the samples. PE and PP were the most abundant MPs in cerebrospinal fluid samples. When using LM patients as controls, a significantly increased risk of IA was observed for subjects in the highest quartile of cerebrospinal fluid PP and PVC levels. Compared to the lowest quartile, the adjusted risk was elevated by 2.25-fold (95% CI: 1.68–5.94) and 3.82-fold (95% CI: 2.57–5.41) for PP and PVC levels, respectively. Our analysis revealed significant (<em>p</em> for trend &lt; 0.01) dose-response relationships between cerebrospinal fluid MP mixture concentrations and IA risk. Bayesian kernel machine regression and quantile g-computation models further revealed synergistic effects of co-occurrence to MPs, with PVC contributing the strongest contribution (weight 55.8%). Our results suggest a potential link between higher cerebrospinal fluid levels of MPs and elevated IA risk, and highlight the need for further investigation into this emerging health risk.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"4 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Environmental Pollution
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1