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2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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Analysing the Performance of a Real-Time Healthcare 4.0 System using Shared Frailty Time to Event Models 使用共享脆弱时间到事件模型分析实时医疗保健4.0系统的性能
Pub Date : 2019-08-05 DOI: 10.1109/CBMS.2019.00129
A. Marshall, Aleksandar Novakovic
This paper introduces the real-time Healthcare 4.0 system, the VILIAlert system and a new approach that we propose for the robust assessment of it's performance. The VILIAlert system alerts clinicians when a patient's tidal volume value rises above the clinically accepted level of 8 ml/kg as beyond this point (> 8 ml/kg), a patient is considered high risk of permanent damage to their lungs. In order to ensure success with the VILIAlert system, the ideal scenario is to ensure that as soon as patients in the Intensive Care Unit experience tidal volume values beyond the 8 ml/kg level, a clinical intervention can be carried out so to minimise the risk of patients ever having permanent damage. The approach has been implemented in the Intensive Care Unit at the Royal Victoria Hospital Belfast, Northern Ireland demonstrating the potential for such an approach to be used across all hospitals in the region.
本文介绍了实时医疗保健4.0系统、VILIAlert系统以及我们提出的一种对其性能进行稳健评估的新方法。当患者的潮气量高于临床可接受的8ml /kg水平(> 8ml /kg)时,VILIAlert系统会向临床医生发出警报,认为患者存在肺部永久性损伤的高风险。为了确保VILIAlert系统的成功,理想的情况是确保重症监护病房的患者一旦经历超过8ml /kg的潮汐量水平,就可以进行临床干预,以尽量减少患者遭受永久性损伤的风险。该办法已在北爱尔兰贝尔法斯特维多利亚皇家医院的重症监护室实施,表明该地区所有医院都有可能采用这种办法。
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引用次数: 4
Performance of Data Enhancements and Training Optimization for Neural Network: A Polyp Detection Case Study 神经网络的数据增强性能和训练优化:息肉检测案例研究
Pub Date : 2019-08-05 DOI: 10.1109/CBMS.2019.00067
F. Henriksen, Rune Jensen, H. Stensland, Dag Johansen, M. Riegler, P. Halvorsen
Deep learning using neural networks is becoming more and more popular. It is frequently used in areas like video analysis, image retrieval, traffic forecast and speech recognition. In this respect, the learning and training process usually requires a lot of data. However, in many areas, data is scarce which is definitely the case in our medical application scenario, i.e., polyp detection in the gastrointestinal tract. Here, colorectal cancer is on the list of most common cancer types, and often, the cancer arises from benign, adenomatous polyps containing dysplastic cells. Detection and removal of polyps can therefore prevent the development of cancer. % Due to high cost, time consumption, patient discomfort and in-accuracy of existing procedures, researchers have started to explore systems for automatic polyp detection to assist and automate current examination procedures. Following the current gained traction for neural networks, and the typical lack of medical data, we explore how data enhancements affect the training and evaluation of the networks in terms of polyp detection accuracy and particularly if it can be used to increase the detection rate. We also experiment with how various training techniques can be used to increase performance. Our experimental results show how data enhancement and training optimization can be used to increase different aspects of the performance, but we also point out mechanisms that have no, and even a negative, effect.
使用神经网络的深度学习正变得越来越流行。它经常用于视频分析、图像检索、交通预测和语音识别等领域。在这方面,学习和培训过程通常需要大量的数据。然而,在很多领域,数据是稀缺的,在我们的医疗应用场景中,即胃肠道息肉的检测,绝对是这种情况。在这里,结直肠癌是最常见的癌症类型之一,通常,癌症起源于含有发育不良细胞的良性腺瘤性息肉。因此,检测和切除息肉可以预防癌症的发展。由于高成本、耗时、患者不适和现有程序的不准确性,研究人员已经开始探索自动息肉检测系统,以辅助和自动化当前的检查程序。随着当前神经网络的发展,以及医疗数据的典型缺乏,我们探索了数据增强如何影响息肉检测准确性方面的网络训练和评估,特别是如果它可以用来提高检测率。我们还试验了如何使用各种训练技术来提高性能。我们的实验结果显示了如何使用数据增强和训练优化来提高性能的不同方面,但我们也指出了没有甚至是负面影响的机制。
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引用次数: 4
Identifying Diabetic Retinopathy from OCT Images using Deep Transfer Learning with Artificial Neural Networks 利用人工神经网络的深度迁移学习从OCT图像中识别糖尿病视网膜病变
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00066
K. Islam, S. Wijewickrema, S. O'Leary
Diabetic retinopathy occurs when the blood vessels inside the retina are damaged as a result of diabetes. Early diagnosis and treatment of this disease is crucial to avoid blindness. Analysis of retinal images such as funduscopy, ultrasonography, and optical coherence tomography (OCT) is typically used in the diagnosis of diabetic retinopathy. In recent years, various automated techniques including deep learning have been used for this purpose. In this paper, we explore how to use deep transfer learning for the diagnosis of diabetic retinopathy using OCT images. We retrain existing deep learning models for this task and investigate how a retrained model can be optimized. We demonstrate that using an optimized pre-trained model as a feature extractor and training a conventional classifier on these features is an effective way to diagnose diabetic retinopathy using OCT images. We show through experiments that the proposed method outperforms similar existing methods with respect to accuracy and training time.
当视网膜内的血管因糖尿病而受损时,就会发生糖尿病性视网膜病变。这种疾病的早期诊断和治疗对于避免失明至关重要。分析视网膜图像,如眼底镜,超声和光学相干断层扫描(OCT)通常用于诊断糖尿病视网膜病变。近年来,包括深度学习在内的各种自动化技术已被用于此目的。在本文中,我们探讨了如何使用深度迁移学习来使用OCT图像诊断糖尿病视网膜病变。我们为此任务重新训练现有的深度学习模型,并研究如何优化重新训练的模型。我们证明了使用优化的预训练模型作为特征提取器并在这些特征上训练传统分类器是使用OCT图像诊断糖尿病视网膜病变的有效方法。实验表明,该方法在准确率和训练时间方面优于现有的类似方法。
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引用次数: 23
Early Radiomic Experiences in Classifying Prostate Cancer Aggressiveness using 3D Local Binary Patterns 使用三维局部二值模式对前列腺癌侵袭性进行早期放射学分类的经验
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00078
R. Sicilia, E. Cordelli, M. Merone, E. Luperto, R. Papalia, G. Iannello, P. Soda
Prostate cancer is the most common form of cancer in Western countries and there is the need to develop clinical decision support systems able to support physicians in the diagnosis of clinical relevant prostate cancer and avoid useless invasive prostate biopsies. In this respect, this paper introduces a radiomic approach that classifies the prostate cancer aggressiveness by combining Three Orthogonal Planes-Local Binary Pattern (TOP - LBP) with other texture measures. Furthermore, to combat the skewed nature of class priors, our proposal employs a data augmentation technique. The results achieved on 99 samples are up-and-coming, they favorably compare against conventional PI-RADS-based approach, and they show also the benefit given by the introduction of TOP-LBP in the radiomic signature.
前列腺癌是西方国家最常见的癌症形式,需要开发临床决策支持系统,以支持医生诊断临床相关的前列腺癌,避免无用的侵入性前列腺活检。在这方面,本文介绍了一种结合三正交平面-局部二值模式(TOP - LBP)和其他纹理测量的前列腺癌侵袭性放射学分类方法。此外,为了对抗类先验的偏斜性质,我们的建议采用了数据增强技术。在99个样品上取得的结果是有前途的,它们与传统的基于pi - ads的方法相比具有优势,并且它们也显示了在放射性特征中引入TOP-LBP所带来的好处。
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引用次数: 7
Fostering Natural Language Question Answering Over Knowledge Bases in Oncology EHR 在肿瘤学电子病历知识库上培养自然语言问答
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00102
M. A. Schwertner, S. Rigo, D. A. Araújo, Allan de Barcelos Silva, B. Eskofier
This paper presents an approach for natural language question answering over a knowledge base generated by a medical texts information extraction process. The primary objective is to present a solution to help practitioners in oncology healthcare clinical environment with an intuitive method to access stored data. We identify health professional's needs in terms of information and interface with EHR systems. After that, we demonstrate a proposal to allow the integration of information extraction from clinical notes, knowledge base generation, and natural language question answering. The primary contributions are the identification of a solution to health professionals needs regarding usability in information access, and the demonstration of advantages obtained in representing health contents in a knowledge base.
本文提出了一种基于医学文本信息提取过程生成的知识库的自然语言问答方法。主要目标是提供一种解决方案,帮助肿瘤医疗保健临床环境中的从业者使用直观的方法访问存储的数据。我们在信息和电子健康档案系统接口方面确定卫生专业人员的需求。之后,我们展示了一个建议,允许从临床记录中提取信息,知识库生成和自然语言问答的集成。主要贡献是确定了一种解决方案,以满足卫生专业人员在信息获取可用性方面的需求,并展示了在知识库中表示卫生内容所获得的优势。
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引用次数: 6
How to Automatically Identify Regions of Interest in High-Resolution Images of Lung Biopsy for Interstitial Fibrosis Diagnosis 如何在高分辨率肺活检图像中自动识别感兴趣区域用于间质性纤维化诊断
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00118
Oscar Cuadros, Bruno S. Faiçal, Paulo Barbosa, B. Hamann, A. Fabro, A. Traina
Airway-centered Interstitial Fibrosis (ACIF) is a histological pattern of Interstitial lung diseases. Its diagnosis requires a multidisciplinary approach, in which diverse information, such as clinical data, computed tomography data, and lung biopsy data, is analyzed. Biopsy samples are digitized at high-resolution. Of crucial interest are broncho-and bronchiolocentric remodeling with extracellular matrix deposition. To analyze an image, specialists have to explore it at low microscope magnification, select a region of interest and export a smaller specified sub-image to be interpreted at higher magnification. This process is performed several times, requiring hours, becoming a tiresome task. We propose a method to support pathologists to identify specific patterns of ACIF in high-resolution images from lung biopsies. This can be done by a) automatic microscope magnification reduction; b) computing the probability of pixels belonging to high-density regions; c) extracting Local Binary Patterns (LBP) of the high-and low-density regions; and d) visualizing them in color. We have evaluated our method on nine high-resolution lung biopsies. We have tested the LBP features of high-and low-density regions with the kNN algorithm and obtained a classification accuracy of 94.4%, which is the highest one reported in the literature for this type of data.
气道中心性间质纤维化(ACIF)是间质性肺疾病的一种组织学模式。它的诊断需要多学科的方法,其中不同的信息,如临床数据,计算机断层扫描数据和肺活检数据进行分析。活检样本以高分辨率数字化。细胞外基质沉积引起的支气管和细支气管中心性重构尤为重要。为了分析图像,专家必须在低显微镜放大率下探索它,选择一个感兴趣的区域,并导出一个较小的指定子图像,以便在更高的放大倍率下进行解释。这个过程要执行几次,需要几个小时,成为一项令人厌烦的任务。我们提出了一种方法来支持病理学家在肺活检的高分辨率图像中识别ACIF的特定模式。这可以通过a)自动降低显微镜放大倍率来实现;B)计算像素属于高密度区域的概率;c)提取高、低密度区域的局部二值模式(LBP);d)用颜色把它们形象化。我们已经在9个高分辨率肺活检中评估了我们的方法。我们用kNN算法对高低密度区域的LBP特征进行了测试,得到了94.4%的分类准确率,这是目前文献中该类数据的最高分类准确率。
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引用次数: 1
DCE-MRI Breast Lesions Segmentation with a 3TP U-Net Deep Convolutional Neural Network 基于3TP U-Net深度卷积神经网络的DCE-MRI乳腺病变分割
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00130
Gabriele Piantadosi, S. Marrone, Antonio Galli, M. Sansone, Carlo Sansone
Nowadays, Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) is increasingly succeeding as a complementary methodology for breast cancer, with Computer Aided Detection/Diagnosis (CAD) systems becoming essential technological tools to provide early detection and diagnosis of tumours. Several CADs make use of machine learning, resulting in a constant design of hand-crafted features aimed at better assisting the physician. In recent years, Deep learning (DL) approaches raised in popularity in many pattern recognition tasks thanks to their ability to learn compact hierarchical features that well fit the specific task to solve. If, on one and, this characteristic suggests to explore DL suitability for biomedical image processing, on the other, it is important to take into account the physiological inheritance of the images under analysis. With this goal in mind, in this work we propose "3TP U-Net", an U-Shaped Deep Convolutional Neural Network that exploits the well-known Three Time Points approach for the lesion segmentation task. Results show that our proposal is able to outperform not only the classical (non-deep) approaches but also some very recent deep proposal, achieving a median Dice Similarity Coefficient of 61.24%.
如今,动态对比增强磁共振成像(DCE-MRI)作为乳腺癌的补充方法越来越成功,计算机辅助检测/诊断(CAD)系统成为提供肿瘤早期检测和诊断的重要技术工具。一些cad使用机器学习,从而不断设计手工制作的功能,旨在更好地协助医生。近年来,深度学习(DL)方法在许多模式识别任务中越来越受欢迎,因为它们能够学习紧凑的层次特征,这些特征非常适合要解决的特定任务。如果,一方面,这一特征表明探索深度学习适合生物医学图像处理,另一方面,考虑所分析图像的生理遗传是很重要的。考虑到这一目标,在这项工作中,我们提出了“3TP U-Net”,这是一种u形深度卷积神经网络,利用众所周知的三时间点方法进行病灶分割任务。结果表明,我们的提议不仅能够优于经典(非深度)方法,而且能够优于一些最近的深度提议,实现中位数骰子相似系数为61.24%。
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引用次数: 17
A Decision Support System to Propose Coaching Plans for Seniors 一种建议老年人教练计划的决策支持系统
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00123
Paula Subías-Beltrán, Silvia Orte, E. Vargiu, Filippo Palumbo, Leonardo Angelini, Omar Abou Khaled, E. Mugellini, M. Caon
This paper presents the decision support system that has been defined and developed under the umbrella of the NESTORE project. The main goal of the proposed system is to help users in selecting coaching plans by proposing personalised recommendations based on their behaviours and preferences. Recognising such behaviours and their evolution over time is therefore a crucial element for tailoring the interaction of the system with the user. A three-layer system composed of pathways, coaching activity plans, and coaching events, constitutes the so-called coaching timeline on which the analysis is grounded. Various techniques are used to model and personalise the recommendations and feedback. Firstly, the indicators are extracted from disparate data sources, then these are modelled through a profiling system and, finally, recommendations on the pathways and coaching plans are performed through a scoring and a tagging system.
本文介绍了在NESTORE项目框架下定义和开发的决策支持系统。提出的系统的主要目标是通过根据用户的行为和偏好提出个性化的建议来帮助用户选择训练计划。因此,识别这些行为及其随时间的演变是定制系统与用户交互的关键因素。一个由路径、教练活动计划和教练事件组成的三层系统构成了所谓的教练时间线,这是分析的基础。使用各种技术来建模和个性化推荐和反馈。首先,从不同的数据源中提取指标,然后通过分析系统对这些指标进行建模,最后,通过评分和标记系统对路径和指导计划进行建议。
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引用次数: 9
Haemodialysis Electronic Patient Portal: A Design Requirements Analysis and Feasibility Study with Domain Experts 血液透析电子患者门户:与领域专家的设计需求分析和可行性研究
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00051
M. Bouamrane, R. Meiklem, Mark D. Dunlop, D. Kingsmore, P. Thomson, K. Stevenson, S. Greenwood
In 2013, the UK national renal registry established 57,000 adults in the UK were treated for advanced kidney failure, 23,683 (42%) receiving haemodialysis. Haemodialysis patients face some of the highest treatment burden in the National Health Service (NHS) and are among the most 'expensive' to treat. In addition, patients endure complex treatment trajectories. In this study, we have sought to gather and synthesise the opinion of clinical and Human Computer Interaction (HCI) domain experts (n=9) to establish a set of initial design requirements in order to test the feasibility of developing a digital aid (i.e. electronic haemodialysis patient portal) to support patients in the course of their treatment. Expert feedback was gathered by means of interviews and focus groups in order to instruct design requirements for a haemodialysis patient portal.
2013年,英国国家肾脏登记处建立了57,000名英国成年人接受晚期肾衰竭治疗,23,683(42%)接受血液透析。血液透析患者在国民健康服务(NHS)中面临着最高的治疗负担,也是治疗费用最高的患者之一。此外,患者还要忍受复杂的治疗过程。在这项研究中,我们试图收集和综合临床和人机交互(HCI)领域专家(n=9)的意见,以建立一套初始设计要求,以测试开发数字辅助设备(即电子血液透析患者门户)的可行性,以支持患者的治疗过程。通过访谈和焦点小组收集专家反馈,以指导血液透析患者门户的设计要求。
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引用次数: 5
Inferential Reasoning Driving Clinical Diagnosis: Suggestions for New Assessment Approaches 推理推理驱动临床诊断:新评估方法的建议
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00113
Carol. Leroy, Yvonne Kammerer, Uwe Oestermeier, Karsten Büringer, M. Bitzer, Peter Gerjets
Experimental research investigating the processes or influencing factors of diagnostic reasoning or diagnostic success is predominantly conducted with case descriptions spanning no more than one A4 page. In this paper, we argue for a more authentic task setting in the form of multiple documents case descriptions, and make suggestions how to design them to suit different research questions. We further review methods used in previous studies, such as think-aloud protocols and written justifications of diagnoses, and discuss how they can be used in order to assess the cognitive processes underlying diagnostic reasoning in more detail. Additionally, based on findings from the field of multiple documents comprehension, we outline how participants' gaze behavior on and their interaction with the documents might also be used to assess processes of information comparison and corroboration during reading as part of participants' diagnostic reasoning process.
调查诊断推理或诊断成功的过程或影响因素的实验研究主要以不超过一页A4纸的病例描述进行。在本文中,我们主张以多个文件案例描述的形式进行更真实的任务设置,并提出如何设计它们以适应不同的研究问题的建议。我们进一步回顾了以前研究中使用的方法,如有声思考协议和诊断的书面证明,并讨论了如何使用它们来更详细地评估诊断推理背后的认知过程。此外,基于多文件理解领域的研究结果,我们概述了参与者对文件的凝视行为及其与文件的互动如何也可用于评估阅读过程中的信息比较和确证过程,作为参与者诊断推理过程的一部分。
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引用次数: 0
期刊
2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)
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