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2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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An Investigation of Interpretable Deep Learning for Adverse Drug Event Prediction 可解释深度学习用于药物不良事件预测的研究
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00075
J. Rebane, Isak Karlsson, P. Papapetrou
A variety of deep learning architectures have been developed for the goal of predictive modelling in regards to detecting health diagnoses in medical records. Several models have placed strong emphases on temporal attention mechanisms and decay factors as a means to include highly temporally relevant information regarding the recency of medical event occurrence while facilitating medical code-level interpretability. In this study we utilise such models with a novel Electronic Patient Record (EPR) data set consisting of both diagnoses and medication data for the purpose of Adverse Drug Event (ADE) prediction. As such, a main contribution of this work is an empirical evaluation of two state-of-the-art deep learning architectures in terms of objective performance metrics for ADE prediction. We also assess the importance of attention mechanisms in regards to their usefulness for medical code-level interpretability, which may facilitate novel insights pertaining to the nature of ADE occurrence within the health care domain.
为了在医疗记录中检测健康诊断的预测建模,已经开发了各种深度学习架构。有几个模型非常强调时间注意机制和衰减因素,以此作为一种手段,在促进医学代码级别的可解释性的同时,纳入与医疗事件发生的近代性有关的高度时间相关的信息。在这项研究中,我们利用这种模型与一种新的电子病历(EPR)数据集,包括诊断和药物数据,用于药物不良事件(ADE)预测。因此,这项工作的主要贡献是根据ADE预测的客观性能指标对两种最先进的深度学习架构进行实证评估。我们还评估了注意机制在医学代码级别可解释性方面的重要性,这可能有助于对医疗保健领域内ADE发生性质的新见解。
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引用次数: 8
Semantic Data Integration Techniques for Transforming Big Biomedical Data into Actionable Knowledge 将生物医学大数据转化为可操作知识的语义数据集成技术
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00116
Maria-Esther Vidal, S. Jozashoori
FAIR principles and the Open Data initiatives have motivated the publication of large volumes of data. Specifically, in the biomedical domain, the size of the data has increased exponentially in the last decade, and with the advances in the technologies to collect and generate data, a faster growth rate is expected for the next years. The available collections of data are characterized by the dominant dimensions of big data, i.e., they are not only large in volume, but they can be also heterogeneous and present quality issues. These data complexity problems impact on the typical tasks of data management, and particularly, in the task of integrating big biomedical data sources. We tackle the problem of big data integration and present a knowledge-driven framework able to extract and integrate data collected from structured and unstructured data sources. The proposed framework resorts to Natural Language Processing techniques to extract knowledge from unstructured data and short text. Furthermore, ontologies and controlled vocabularies, e.g., UMLS, are utilized to annotate the extracted entities and relations with terms from the ontology or controlled vocabulary. The annotated data is integrated into a knowledge graph. A unified schema is used to describe the meaning of the integrated data as well as the main properties and relations. As proof of concept, we show the results of applying the proposed framework to integrate clinical records from lung cancer patients with data extracted from open data sources like Drugbank and PubMed. The created knowledge graph enables the discovery of interactions between drugs in the treatments prescribed to lung cancer patients.
公平原则和开放数据倡议推动了大量数据的发布。具体来说,在生物医学领域,数据的规模在过去十年中呈指数级增长,随着收集和生成数据技术的进步,预计未来几年的增长速度将更快。可用的数据集合的特点是大数据的主要维度,即它们不仅体积大,而且可能是异构的,并且存在质量问题。这些数据复杂性问题影响了典型的数据管理任务,特别是集成生物医学大数据源的任务。我们解决了大数据集成的问题,并提出了一个知识驱动的框架,能够从结构化和非结构化数据源中提取和集成数据。该框架利用自然语言处理技术从非结构化数据和短文本中提取知识。此外,本体和受控词汇表(例如UMLS)被用来用本体或受控词汇表中的术语来注释提取的实体和关系。将标注的数据集成到知识图中。使用统一的模式来描述集成数据的含义以及主要属性和关系。作为概念的证明,我们展示了应用所提出的框架将肺癌患者的临床记录与从Drugbank和PubMed等开放数据源提取的数据整合在一起的结果。所创建的知识图谱能够发现用于肺癌患者治疗的药物之间的相互作用。
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引用次数: 6
Mobile Mental Health: A Review of Applications for Depression Assistance 流动心理健康:抑郁症援助应用综述
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00143
A. Teles, I. Rodrigues, Davi Viana, Francisco Silva, L. Coutinho, M. Endler, R. A. Rabelo
Depression is a mental disorder characterized by persistent sadness, loss of interest, and a set of behavioral changes. The high prevalence of depression imposes a significant burden on the world population, demanding methods capable of monitoring and treating this mental disorder. Currently, a large number of mobile applications have been designed to provide support to depressive people. This paper aims to identify, analyze and characterize the current state of mobile applications focused on depression. To do so, we conducted a systematic review of applications for depression assistance. The two most popular mobile app stores (Google Play Store and Apple App Store) have been explored to find the most relevant apps. After applying the inclusion and exclusion criteria and performing the quality assessment of the results, 216 applications were selected for the data extraction phase, where we summarized their benefits and limitations and identified gaps and trends. The results of this review evidenced that there is a growth in the diversity of apps' purposes such as chatbot, online therapy, educational tools, mood tracker, testing, and self-help.
抑郁症是一种精神障碍,其特征是持续悲伤,失去兴趣和一系列行为改变。抑郁症的高患病率给世界人口带来了沉重负担,需要能够监测和治疗这种精神障碍的方法。目前,大量的移动应用程序被设计为为抑郁症患者提供支持。本文旨在识别、分析和描述当前专注于抑郁症的移动应用程序的状态。为此,我们对抑郁症援助申请进行了系统审查。我们在两个最流行的手机应用商店(Google Play Store和Apple app Store)中寻找最相关的应用。在应用纳入和排除标准并对结果进行质量评估后,我们选择了216个应用程序进入数据提取阶段,在此阶段我们总结了它们的优点和局限性,并确定了差距和趋势。这项调查的结果证明,应用程序的用途越来越多样化,比如聊天机器人、在线治疗、教育工具、情绪追踪器、测试和自助。
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引用次数: 22
Optic Disc and Cup Segmentation for Glaucoma Characterization Using Deep Learning 基于深度学习的青光眼视盘和视杯分割
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00100
Jongwoo Kim, L. Tran, E. Chew, Sameer Kiran Antani
Glaucoma is one of the most common eye diseases that can cause irreversible vision loss due to damage to the optic nerve. Ophthalmologists consider a cup to optic disc ratio greater than 0.3 to be suggestive of glaucoma. Unfortunately, there is high variability among ophthalmologists in estimating the ratio since it is not easy to reliably measure optic disc and cup areas in a fundus image. Therefore, this paper proposes automatic methods to segment the optic disc and cup areas. There are two steps to estimate the ratio: region of interest (ROI) area detection (where optic disc is in the center) from a fundus image, followed by optic disc and cup segmentation. This paper focuses on automated methods to segment the optic disc and cup from the ROI. Fully convolutional networks (FCN) with U-Net architectures are used for the segmentation. The RIGA dataset (composed of three different fundus image datasets: MESSIDOR, Bin Rushed, and Magrabi), containing 750 fundus images, is used to train and test the FCNs. Our proposed FCNs show relatively better performance than other existing algorithms. The best segmentation results for optic disc show 0.95 Jaccard index, 0.98 F-measure, and 0.99 accuracy. The best segmentation results for cup show 0.80 Jaccard index, 0.88 F-measure, and 0.99 accuracy.
青光眼是最常见的眼病之一,由于视神经受损,可导致不可逆的视力丧失。眼科医生认为杯与视盘之比大于0.3提示有青光眼。不幸的是,由于不容易在眼底图像中可靠地测量视盘和杯状区域,眼科医生在估计比例方面存在很大的差异。因此,本文提出了自动分割视盘和视杯区域的方法。估计比率有两个步骤:从眼底图像中检测感兴趣区域(ROI)区域(视盘在中心),然后分割视盘和杯。本文主要研究了从ROI图像中分割视盘和视杯的自动化方法。采用U-Net结构的全卷积网络(FCN)进行分割。RIGA数据集(由MESSIDOR、Bin rush和Magrabi三个不同的眼底图像数据集组成)包含750张眼底图像,用于训练和测试fns。我们提出的fns比其他现有算法表现出相对更好的性能。视盘的最佳分割结果为Jaccard指数0.95,F-measure 0.98,准确率0.99。cup的最佳分割结果为Jaccard指数0.80,F-measure 0.88,准确率0.99。
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引用次数: 25
Extracting Body Landmarks from Videos for Parkinson Gait Analysis 从视频中提取帕金森步态特征
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00082
H. Fleyeh, J. Westin
Patients with Parkinson disease (PD) exhibit a gait disorder called festinating gait which is caused by deficiency of dopamine in the basal ganglia. To analyze gait of patients with PD, different spatiotemporal parameters such as stride length, cadence, and walking speed should be calculated. This paper aims to present a method to extract useful information represented by the positions of certain landmarks on the human body that can be used for analysis of PD patients' gait. This method is tested using 132 videos collected from 7 PD patients and 7 healthy controls. The positions of 4 body landmarks, namely body's center of gravity (COG), the position of the head, and the position of the feet, was computed using a total of more than 41000 of video frames. Results of object's movement plots show high level of accuracy in the calculation of the body landmarks.
帕金森氏症(PD)患者表现出一种步态紊乱,称为“进食步态”,这是由基底神经节多巴胺缺乏引起的。为了分析PD患者的步态,需要计算不同的时空参数,如步幅、步速、步行速度。本文旨在提出一种提取人体某些地标位置表示的有用信息的方法,用于PD患者的步态分析。该方法通过收集7名PD患者和7名健康对照者的132个视频进行了测试。4个身体标志的位置,即身体的重心(COG),头部的位置,和脚的位置,计算使用总共超过41000个视频帧。物体运动图的计算结果表明,人体标志点的计算精度较高。
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引用次数: 7
m-Health and Autism: Recognizing Stress and Anxiety with Machine Learning and Wearables Data 移动健康和自闭症:用机器学习和可穿戴设备数据识别压力和焦虑
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00144
A. Masino, Daniel Forsyth, H. Nuske, J. Herrington, Jeffrey W. Pennington, Yelena Kushleyeva, Christopher P. Bonafide
Consumer-grade wearables provide physiological measurements which may inform m-health applications that predict adverse outcomes. Autism Spectrum Disorder (ASD) represents a compelling example. Many individuals with ASD present with challenging behaviors that are preceded by physiological changes. Physiological measures could, therefore, support real-time interventions to avert challenging behaviors in various social settings. However, no prior research has demonstrated a methodological approach to detect these changes using wearable device data. We sought to demonstrate a machine learning approach that uses wearables data to differentiate physiological states associated with stressful and non-stressful scenarios in children with ASD. In a controlled laboratory setting, we collected heart rate and RR interval measurements during rest and during activities designed to mimic stress using a consumer-grade wearable device. Our analysis included 38 participants (22 ASD, 16 non-ASD). Following outlier removal, we extracted 20 statistical features from data collected during each patient's rest and stressful periods. Using nested leave-one-out cross-validation over 76 sample periods (38 rest / 38 stress), we trained and evaluated logistic regression (LR) and support vector machine (SVM) classifiers to label each validation sample as a rest or stressful period. The SVM and LR models achieved 93% and 87% accuracy, respectively. These results suggest that machine learning models combined with wearables data may support real-time m-health intervention applications.
消费级可穿戴设备提供生理测量,可为预测不良后果的移动健康应用程序提供信息。自闭症谱系障碍(ASD)就是一个令人信服的例子。许多ASD患者在生理变化之前表现出具有挑战性的行为。因此,生理测量可以支持实时干预,以避免各种社会环境中的挑战性行为。然而,之前的研究还没有证明使用可穿戴设备数据检测这些变化的方法学方法。我们试图展示一种机器学习方法,该方法使用可穿戴设备数据来区分ASD儿童与压力和非压力情景相关的生理状态。在一个受控的实验室环境中,我们收集了休息和活动期间的心率和RR间隔测量值,这些活动旨在使用消费级可穿戴设备模拟压力。我们的分析包括38名参与者(22名ASD, 16名非ASD)。在去除异常值后,我们从每个患者休息和压力期收集的数据中提取了20个统计特征。使用76个样本期(38个休息期/ 38个压力期)的嵌套留一交叉验证,我们训练并评估了逻辑回归(LR)和支持向量机(SVM)分类器,将每个验证样本标记为休息期或压力期。SVM和LR模型的准确率分别达到93%和87%。这些结果表明,结合可穿戴设备数据的机器学习模型可能支持实时移动医疗干预应用。
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引用次数: 12
Looking for Emergent Systems in Computer-Based Medical Systems: A Review from the Last Decade 在以计算机为基础的医疗系统中寻找紧急系统:回顾过去十年
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00055
Sandro Luís Freire de Castro Silva, N. Antônio, Marcelo Fornazin, R. Santos
There are several challenges to support healthcare context; however, it is necessary to investigate a current reality in the Computer-Based Medical Systems (CBMS) field: the incorporation of emergent systems. This paper presents a review on how emergent systems have been investigated in last decade in the context of CBMS conference series. Results show that CBMS strategies should consider that these systems cannot be treated as something simple and that a deepest analysis can show its real complexity.
支持医疗保健环境存在一些挑战;然而,有必要调查当前的现实,在计算机为基础的医疗系统(CBMS)领域:合并应急系统。本文介绍了在过去十年中,在CBMS系列会议的背景下,如何研究紧急系统。结果表明,CBMS策略应该考虑到这些系统不能被视为简单的东西,而最深入的分析可以显示其真正的复杂性。
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引用次数: 6
EVOTION – Big Data Supporting Public Hearing Health Policies 进化-支持公共听力健康政策的大数据
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00012
J. Christensen, N. H. Pontoppidan
Hearing Loss (HL) is a highly prevalent chronic disease (the 5th cause of disability world-wide), which increases the risk of cognitive decline, mental illness, and depression, and furthermore leads to social isolation, unemployment/early retirement, loss of income and work discrimination. To enable successful holistic management of HL, appropriate public health policies for HL prevention, early diagnosis, long-term treatment and rehabilitation are required. In addition, HL management would benefit from detection and prevention of cognitive decline; protection from noise; and initiatives for socioeconomic inclusion of HL patients. However, the evidence for forming such policies and enabling true holistic HL management is lacking. Specifically, holistic HL management policies require access to and analysis of heterogeneous data sources. In EVOTION, such big data from five different clinical organizations are available and continuous acquisition of real-time data produced by sensors and hearing aids used by HL patients will support their continuous update. In order to utilize these data in forming holistic HL management policies, EVOTION is developing an integrated IT platform supporting: 1) the acquisition and analysis of heterogeneous big data related to HL; 2) policy decision making, i.e. selection of effective interventions related to the holistic management of HL based on the outcomes of 1) and the formulation of related public health policies; and 3) specification and continuous monitoring of the effects of such policies in a sustainable manner.
听力损失是一种非常普遍的慢性疾病(全球第五大致残原因),它增加了认知能力下降、精神疾病和抑郁症的风险,并进一步导致社会孤立、失业/提前退休、收入损失和工作歧视。为了成功地全面管理HL,需要制定适当的HL预防、早期诊断、长期治疗和康复公共卫生政策。此外,发现和预防认知能力下降将有利于HL的管理;防止噪音;以及促进HL患者社会经济包容的举措。然而,形成这样的政策和实现真正的整体HL管理的证据是缺乏的。具体来说,整体HL管理策略需要访问和分析异构数据源。在EVOTION中,来自五个不同临床机构的大数据是可用的,HL患者使用的传感器和助听器产生的实时数据的持续采集将支持它们的持续更新。为了利用这些数据形成整体的HL管理政策,evoltion正在开发一个集成的IT平台,支持:1)获取和分析HL相关的异构大数据;2)政策决策,即根据1)的结果选择与HL整体管理相关的有效干预措施和制定相关公共卫生政策;3)以可持续的方式规范和持续监测这些政策的效果。
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引用次数: 4
A New Syntactic Approach for Masses Classification in Digital Mammograms 数字乳房x光片肿块分类的新句法方法
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00083
Ricardo Wandré Dias Pedro, Ariane Machado-Lima, Fátima L. S. Nunes
Breast cancer is one of the most common cancers that affect women worldwide being responsible for about 15% of all deaths related to cancer in the world. Mammography is one of the main techniques to help early detection of breast cancer. Although there are some characteristics that should be considered to discriminate benign and malignant masses, only about 15 to 30% of the cases sent to biopsies are malignant. To aid in the diagnosis of this disease, several CAD systems were proposed and developed to make a second opinion to the physicians, but the theory of formal languages is underexplored in this field. This paper presents a new syntactic approach to discriminate benign and malignant masses in digital mammography. Preliminary results showed that this approach is very promising, since our classifier achieved accuracies from 80% to 100% depending on the model and features used, applied on two different databases.
乳腺癌是影响全世界妇女的最常见癌症之一,约占世界上与癌症相关的所有死亡人数的15%。乳房x光检查是帮助早期发现乳腺癌的主要技术之一。虽然有一些特征可以用来区分肿块的良恶性,但只有约15%至30%的活检病例是恶性的。为了帮助诊断这种疾病,人们提出并开发了一些CAD系统,以向医生提供第二意见,但形式语言理论在这一领域尚未得到充分探索。本文提出了一种新的鉴别数字乳房x线摄影中良恶性肿块的句法方法。初步结果表明,这种方法非常有前途,因为我们的分类器根据所使用的模型和特征在两个不同的数据库上应用,达到了80%到100%的准确率。
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引用次数: 4
Big Data Against Childhood Obesity, the BigO Project 对抗儿童肥胖的大数据,BigO项目
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00023
A. Delopoulos
BigO (bigoprogram.eu) is an EU-funded project that collects objective evidence on the causes of obesity in local communities and helps public health authorities design effective counter obesity interventions. A novel technological platform is being built relying on mobile devices and sensors for data acquisition combined with big data analytics and visualization. During the 4 year project duration the BigO platform will be used by 9000 school and age-matched obese children and adolescents as sources for community data. Led by Aristotle University of Thessaloniki, the project brings together schools, health and clinical scientists, technology providers, personal health solutions businesses and mobile communication providers in Greece, Sweden, Ireland, Spain and the Netherlands.
BigO (bigoprogram.eu)是一个欧盟资助的项目,旨在收集当地社区肥胖原因的客观证据,并帮助公共卫生当局设计有效的反肥胖干预措施。基于移动设备和传感器的数据采集与大数据分析和可视化相结合的新型技术平台正在构建中。在为期4年的项目期间,9000名学校和年龄匹配的肥胖儿童和青少年将使用BigO平台作为社区数据来源。该项目由塞萨洛尼基亚里士多德大学牵头,汇集了希腊、瑞典、爱尔兰、西班牙和荷兰的学校、卫生和临床科学家、技术提供商、个人健康解决方案企业和移动通信提供商。
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引用次数: 3
期刊
2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)
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