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2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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De–randomized Meta-Differential Evolution for Calculating and Predicting Glucose Levels 计算和预测血糖水平的非随机元差分进化
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00064
T. Koutny, A. D. Cioppa, I. D. Falco, E. Tarantino, U. Scafuri, M. Krcma
A physiological model improves delivered healthcare, when constructing a medical device. Such a model comprises a number of parameters. While an analytical method determines model parameters, an evolutionary algorithm can improve them further. As evolutionary algorithms were designed on top of random-number generators, their results are not deterministic. This raises a concern about their applicability to medical devices. Medical-device algorithm must produce an output with a minimum guaranteed accuracy. Therefore, we applied de-randomized sequences to Meta-Differential Evolution instead of using a random-number generator. Eventually, we designed an optimization method based on zooming with derandomized sequences as an alternative to the Meta-Differential Evolution. As the experimental setup, we predicted glucose-level signal to cover a blind window of glucose-monitoring signal that results from a physiological lag in glucose transportation. Completely de-randomized differential evolution exhibited the same accuracy and precision as completely non-deterministic differential evolution. They produced 93% of glucose levels with relative error less than or equal to 15%.
在构建医疗设备时,生理模型可以改善交付的医疗保健。这样的模型包括许多参数。分析方法确定模型参数,而进化算法可以进一步改进模型参数。由于进化算法是在随机数生成器的基础上设计的,其结果是不确定的。这引起了对它们在医疗器械中的适用性的关注。医疗设备算法必须产生具有最低保证精度的输出。因此,我们将去随机化序列应用于元差分进化,而不是使用随机数生成器。最后,我们设计了一种基于非随机化序列缩放的优化方法,作为元差分进化的替代方法。作为实验设置,我们预测葡萄糖水平信号覆盖了葡萄糖运输生理滞后导致的葡萄糖监测信号的盲窗。完全去随机化的差异进化与完全非确定性的差异进化具有相同的准确性和精密度。它们产生了93%的葡萄糖水平,相对误差小于或等于15%。
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引用次数: 3
The Effect of Practice Distribution on Skill Retention in Virtual Reality Temporal Bone Surgery Training 虚拟现实颞骨外科训练中练习分布对技能保留的影响
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00101
Cassandra Williams, S. Wijewickrema, P. Piromchai, S. O'Leary
Virtual reality (VR) simulation has had various applications since its establishment as a means of replicating real-life scenarios. Surgical training is a rapidly growing area for the application of VR, and there is evidence to suggest that skills learned during VR training are transferable to the operating theatre. When developing an effective VR surgical training curriculum, practice distribution is a major factor. Research has found that distributed practice (sessions spread over time) is superior to massed practice (in one session). In this paper, we explore the effect of three forms of distributed practice (daily, weekly, and monthly) on skill retention in VR temporal bone surgery training. We show through a randomised trial that significant skill retention may be achieved irrespective of practice spacing for these three types of distributed practice if other factors of surgical education, such as task demonstration, performance feedback, and task repetition are properly incorporated into the program.
虚拟现实(VR)仿真作为一种复制现实场景的手段,自建立以来已经有了各种各样的应用。外科培训是VR应用的一个快速增长的领域,有证据表明,在VR培训中学习的技能可以转移到手术室。在制定有效的VR外科培训课程时,实践分布是一个主要因素。研究发现,分散练习(在一段时间内分散练习)比集中练习(一次练习)更有效。在本文中,我们探讨了三种形式的分布式练习(每日,每周和每月)对VR颞骨手术训练中技能保留的影响。我们通过一项随机试验表明,如果将外科教育的其他因素,如任务演示、绩效反馈和任务重复适当地纳入计划中,那么无论这三种类型的分布式实践的实践间隔如何,都可以实现显著的技能保留。
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引用次数: 0
Estimating Uncertainty in Deep Learning for Reporting Confidence to Clinicians when Segmenting Nuclei Image Data 估计深度学习的不确定性,以在分割核图像数据时向临床医生报告信心
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00072
Biraja Ghoshal, A. Tucker, B. Sanghera, W. Wong
Deep Learning, which involves powerful black box predictors, has achieved a state-of-the-art performance in medical image analysis such as segmentation and classification for diagnosis. However, in spite of these successes, these methods focus exclusively on improving the accuracy of point predictions without assessing the quality of their outputs. Knowing how much confidence there is in a prediction is essential for gaining clinicians' trust in the technology. Monte-Carlo dropout in neural networks is equivalent to a specific variational approximation in Bayesian neural networks and is simple to implement without any changes in the network architecture. It is considered state-of-the-art for estimating uncertainty. However, in classification, it does not model the predictive probabilities. This means that we are not capturing the true underlying uncertainty in the prediction. In this paper, we propose an uncertainty estimation framework for classification by decomposing predictive probabilities into two main types of uncertainty in Bayesian modelling: aleatoric and epistemic uncertainty (representing uncertainty in the quality of the data and in the model parameters, respectively). We demonstrate that the proposed uncertainty quantification framework using the Bayesian Residual U-Net (BRUNet) provides additional insight for clinicians when analysing images with help from deep learners. In addition, we demonstrate how the resulting uncertainty depends on the dropout rates using images from nuclei in divergent medical images.
深度学习涉及强大的黑匣子预测器,在医学图像分析中取得了最先进的性能,例如用于诊断的分割和分类。然而,尽管取得了这些成功,这些方法只关注于提高点预测的准确性,而没有评估其输出的质量。了解对预测有多大的信心对于获得临床医生对该技术的信任至关重要。神经网络中的蒙特卡罗dropout等价于贝叶斯神经网络中的特定变分近似,实现简单,不需要改变网络结构。它被认为是最先进的估计不确定性。然而,在分类中,它没有对预测概率进行建模。这意味着我们没有捕捉到预测中真正潜在的不确定性。在本文中,我们提出了一个分类的不确定性估计框架,将预测概率分解为贝叶斯建模中的两种主要不确定性类型:任意不确定性和认知不确定性(分别表示数据质量和模型参数的不确定性)。我们证明,使用贝叶斯残差U-Net (BRUNet)提出的不确定性量化框架为临床医生在深度学习器的帮助下分析图像提供了额外的见解。此外,我们演示了如何产生的不确定性取决于使用图像从核在发散医学图像的辍学率。
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引用次数: 16
Digitizing the Informed Consent: the Challenges to Design for Practices 数字化知情同意:为实践设计的挑战
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00127
Michela Assale, Erica Barbero, F. Cabitza
This paper reports a user study performed to assess the usability of a Web-based electronic informed consent application called DICE, which is aimed at supporting patients in the process of reading, understanding and using the informed consent as a trigger for further interaction with the team of care givers. In particular, we performed a questionnaire-based study and a series of individual semi-structured interviews to understand whether the application is usable and can be used in real-world settings, respectively. We found that patients could appreciate the availability of interactive tools like DICE, but health professionals believe that its actual adoption in current workflows and practices could be hampered by the chronic lack of time and health operators who could timely address the licit requests that such a tool could bring to light.
本文报告了一项用户研究,旨在评估基于web的电子知情同意书应用程序DICE的可用性,该应用程序旨在支持患者在阅读、理解和使用知情同意书的过程中,作为与护理人员团队进一步互动的触发器。特别是,我们分别进行了基于问卷的研究和一系列个人半结构化访谈,以了解应用程序是否可用,是否可以在现实环境中使用。我们发现,患者可以欣赏像DICE这样的交互式工具的可用性,但卫生专业人员认为,在当前的工作流程和实践中,由于长期缺乏时间和卫生操作员能够及时解决此类工具可能带来的合法请求,因此实际采用该工具可能会受到阻碍。
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引用次数: 5
Rule-Based Method to Develop Question-Answer Dataset from Chest X-Ray Reports 基于规则的胸部x光报告问答数据集开发方法
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00016
Jie Wang, Hairong Lv, R. Jiang, Zhen Xie
Available and objective clinical documents are important for research of assistant diagnosis, development of algorithms, and education. To facilitate the readability and variability of clinical documents, this paper presents a rule-based approach to develop a question-answer dataset for chest X-rays from a public collection of radiology examinations, including both images and radiologist narrative reports. Our method simplified the complicated reports via hand-selected keywords, generated more than 63 thousand question-answer pairs via hand-written patterns, and augmented the question-answer dataset to more than 130 thousand pairs via rule-based question answering. To the best of our knowledge, this is the first generated question-answer dataset for chest X-rays by rule-based method. The dataset is promising for future researches and applications such as visual question answering, computer-aided diagnosis and so on.
客观的临床文献对辅助诊断的研究、算法的发展和教育都很重要。为了促进临床文件的可读性和可变性,本文提出了一种基于规则的方法,从放射学检查的公共收集中开发胸部x射线的问答数据集,包括图像和放射科医生的叙述报告。我们的方法通过手工选择关键词简化了复杂的报告,通过手写模式生成了6.3万多对问答,并通过基于规则的问答将问答数据集扩展到13万多对。据我们所知,这是第一个通过基于规则的方法生成的胸部x射线问答数据集。该数据集在视觉问答、计算机辅助诊断等方面具有广阔的应用前景。
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引用次数: 1
Recognition of Time Expressions in Spanish Electronic Health Records 西班牙电子健康记录中时间表达式的识别
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00025
Marjan Najafabadipour, M. Zanin, A. R. González, C. Gonzalo-Martín, B. García, V. Calvo, J. L. Cruz-Bermúdez, M. Provencio, Ernestina Menasalvas Ruiz
The widespread adoption of Electronic Health Records (EHRs) is generating an ever-increasing amount of unstructured clinical texts. Processing time expressions from these domain-specific-texts is crucial for the discovery of patterns that can help in the detection of medical events and building the patient's natural history. In medical domain, the recognition of time information from texts is challenging due to their lack of structure; usage of various formats, styles and abbreviations; their domain specific nature; writing quality; and the presence of ambiguous expressions. Furthermore, despite of Spanish occupying the second position in the world ranking of number of native speakers, to the best of our knowledge, no Natural Language Processing (NLP) tools have been introduced for the recognition of time expressions from clinical texts, written in this particular language. Therefore, in this paper, we propose a Temporal Tagger for identifying and normalizing time expressions appeared in Spanish clinical texts. We further compare our Temporal Tagger with the Spanish version of SUTime. By using a large dataset comprising EHRs of people suffering from lung cancer, we show that our developed Temporal Tagger, with an F1 score of 0.93, outperforms SUTime, with an F1 score of 0.797.
电子健康记录(EHRs)的广泛采用正在产生越来越多的非结构化临床文本。处理来自这些领域特定文本的时间表达式对于发现有助于检测医疗事件和构建患者自然病史的模式至关重要。在医学领域,文本时间信息的识别由于缺乏结构而具有挑战性;使用各种格式、样式和缩写;它们的领域特殊性;写作质量;以及歧义表达的存在。此外,尽管西班牙语在世界上以西班牙语为母语的人数排名第二,但据我们所知,还没有引入自然语言处理(NLP)工具来识别用这种特定语言编写的临床文本中的时间表达式。因此,在本文中,我们提出了一个时间标记器来识别和规范化西班牙临床文本中出现的时间表达。我们进一步将我们的时间标记器与西班牙语版的SUTime进行比较。通过使用包含肺癌患者电子病历的大型数据集,我们发现我们开发的Temporal Tagger的F1得分为0.93,优于SUTime的F1得分为0.797。
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引用次数: 8
3DBGrowth: Volumetric Vertebrae Segmentation and Reconstruction in Magnetic Resonance Imaging 3DBGrowth:磁共振成像中椎体体积分割和重建
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00091
Jonathan S. Ramos, M. Cazzolato, Bruno S. Faiçal, M. Nogueira-Barbosa, C. Traina, A. Traina
Segmentation of medical images is critical for making several processes of analysis and classification more reliable. With the growing number of people presenting back pain and related problems, the semi-automatic segmentation and 3D reconstruction of vertebral bodies became even more important to support decision making. A 3D reconstruction allows a fast and objective analysis of each vertebrae condition, which may play a major role in surgical planning and evaluation of suitable treatments. In this paper, we propose 3DBGrowth, which develops a 3D reconstruction over the efficient Balanced Growth method for 2D images. We also take advantage of the slope coefficient from the annotation time to reduce the total number of annotated slices, reducing the time spent on manual annotation. We show experimental results on a representative dataset with 17 MRI exams demonstrating that our approach significantly outperforms the competitors and, on average, only 37% of the total slices with vertebral body content must be annotated without losing performance/accuracy. Compared to the state-of-the-art methods, we have achieved a Dice Score gain of over 5% with comparable processing time. Moreover, 3DBGrowth works well with imprecise seed points, which reduces the time spent on manual annotation by the specialist.
医学图像的分割是使分析和分类过程更加可靠的关键。随着越来越多的人出现背痛和相关问题,椎体的半自动分割和3D重建对于支持决策变得更加重要。3D重建允许对每个椎骨状况进行快速客观的分析,这可能在手术计划和评估合适的治疗方法中发挥重要作用。在本文中,我们提出了3DBGrowth,它在有效的平衡增长方法上对二维图像进行了三维重建。我们还利用标注时间的斜率系数来减少标注切片的总数,减少人工标注的时间。我们在17个MRI检查的代表性数据集上展示了实验结果,表明我们的方法明显优于竞争对手,平均而言,只有37%的椎体内容的总切片必须进行注释,而不会失去性能/准确性。与最先进的方法相比,我们在相当的处理时间内实现了超过5%的骰子得分增益。此外,3DBGrowth可以很好地处理不精确的种子点,这减少了专家在手动注释上花费的时间。
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引用次数: 5
A Translational Wireless Deep Brain Stimulation Monitoring System for Chronic Brain Signal Recording to Automate Neural Disorder Onset Recording 一种用于慢性脑信号记录的平移式无线深部脑刺激监测系统,实现神经紊乱发作记录的自动化
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00027
William Drew, T. Denison, S. Stanslaski
Millions of people worldwide suffer from neurological disorders such as epilepsy, movement disorders, and obsessive-compulsive disorder (OCD), depression, and delirium. To provide relief from these disorders, brain stimulation therapies have been shown to be effective at controlling onsets of seizures, tremors, dyskinesia, dystonia, and OCD episodes. Current development of brain stimulation therapies has pivoted toward closed-loop control of sensing onset events and correspondingly delivering adaptive stimulation. Development of closed-loop brain stimulation therapies for neurological disorders rely on the identification of neural biomarkers. As such, a brain signal monitoring system that can chronically record these neurological events is essential to the continued development of neuromodulation systems and therapies. Through analyzing clinical data, neural disorder biomarkers can be identified and novel therapies can be optimized. This paper outlines the development of a translational deep brain stimulation monitoring system utilizing Medtronic's RC+S System to help clinicians and patients accurately record and document neural disorder onset events. With this neural data, stimulation therapy parameters can be adjusted using the system without requiring an in-person office visit. The system is capable of wirelessly communicating with multiple implanted neurostimulators, monitoring disorder onset biomarkers, and periodically downloading real-time brain signal data as well as loop recordings triggered by device-detected disorder onset events. This translational system and neural disorder onset data can be used to optimize therapies, minimize symptom onsets, enable episodic care management, and improve chronic care management.
全世界有数百万人患有神经系统疾病,如癫痫、运动障碍、强迫症、抑郁症和谵妄。为了缓解这些疾病,脑刺激疗法已被证明对控制癫痫发作、震颤、运动障碍、肌张力障碍和强迫症发作有效。目前脑刺激疗法的发展已转向闭环控制的感觉发作事件和相应的提供适应性刺激。神经系统疾病的闭环脑刺激疗法的发展依赖于神经生物标志物的鉴定。因此,能够长期记录这些神经事件的脑信号监测系统对于神经调节系统和治疗的持续发展至关重要。通过分析临床数据,可以识别神经障碍的生物标志物,并优化新的治疗方法。本文概述了利用美敦力的RC+S系统开发一种转化式脑深部刺激监测系统,以帮助临床医生和患者准确记录和记录神经疾病的发病事件。有了这些神经数据,可以使用该系统调整刺激治疗参数,而不需要亲自去办公室。该系统能够与多个植入的神经刺激器进行无线通信,监测疾病发作的生物标志物,并定期下载实时脑信号数据,以及由设备检测到的疾病发作事件触发的循环记录。该转化系统和神经疾病发病数据可用于优化治疗,最小化症状发作,实现发作性护理管理,并改善慢性护理管理。
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引用次数: 0
Inspecting a Machine Learning Based Clinical Risk Calculator: A Practical Perspective 检查基于机器学习的临床风险计算器:一个实用的视角
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00073
Q. Thurier, Ning Hua, L. Boyle, A. Spyker
Health is reaching a point where machines are more accurate than humans, or at least as accurate but with less effort, in more and more applications. However, accuracy alone is not enough, explanation and understanding is equally important to clinicians, governments, and patients. Possibly leading to loss of health benefits potentially realized through increasingly accurate algorithms. However, various techniques exist for auditing machine learning systems via insightful visualisations. Modelling best practices, parallel computations and open source technologies facilitate implementation of these techniques. This paper leverages several of these methods to increase interpretability for a black-box clinical risk calculator, hopefully opening the door to a better adoption of modern machine learning pipelines in the healthcare sector.
在越来越多的应用中,机器正在达到比人类更准确的地步,或者至少和人类一样准确,但更省力。然而,仅仅准确是不够的,解释和理解对临床医生、政府和患者同样重要。可能会导致失去可能通过越来越精确的算法实现的健康益处。然而,有各种各样的技术可以通过深刻的可视化来审计机器学习系统。建模最佳实践、并行计算和开源技术促进了这些技术的实现。本文利用其中几种方法来提高黑箱临床风险计算器的可解释性,希望为医疗保健领域更好地采用现代机器学习管道打开大门。
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引用次数: 2
Biofeedback in Breast Cancer Rehabilitation: Applying the WHO ICF Core Set to Identify Opportunities and Recommendations 乳腺癌康复中的生物反馈:应用WHO ICF核心集来确定机会和建议
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00122
Louise Brennan, E. Dorronzoro, B. Caulfield
Digital biofeedback technologies are used in physical rehabilitation to improve motor learning and enhance engagement with therapies, but they are unfrequently used in breast cancer rehabilitation. Digital biofeedback interventions should be custom-made for the specific breast cancer context. The WHO ICF Core Set for Breast Cancer describes this context by itemising the biopsychosocial and environmental factors associated with breast cancer. We analysed this Core Set to identify opportunities for biofeedback intervention, and to make recommendations for successful, inclusive design of digital biofeedback interventions in breast cancer rehabilitation. Impairments of strength, joint movement and upper limb function present opportunities for the development of digital biofeedback interventions. Factors related to sensory loss, lymphoedema, chemotherapy-related cognitive dysfunction and fatigue should be considered when designing and evaluating biofeedback systems.
数字生物反馈技术用于物理康复,以改善运动学习和加强治疗,但它们很少用于乳腺癌康复。数字生物反馈干预措施应针对特定的乳腺癌情况量身定制。世卫组织国际癌症基金会乳腺癌核心集通过逐项列出与乳腺癌相关的生物、心理、社会和环境因素来描述这一背景。我们分析了这个核心集,以确定生物反馈干预的机会,并为乳腺癌康复中成功的、包容性的数字生物反馈干预设计提出建议。力量、关节运动和上肢功能的损伤为数字生物反馈干预的发展提供了机会。在设计和评估生物反馈系统时,应考虑与感觉丧失、淋巴水肿、化疗相关的认知功能障碍和疲劳相关的因素。
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引用次数: 0
期刊
2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)
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