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2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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LOWER-LIMB FOLLOW-UP: A Surface Electromyography Based Serious Computer Game and Patient Follow-Up System for Lower Extremity Muscle Strengthening Exercises in Physiotherapy and Rehabilitation 下肢随访:基于表面肌电图的严肃电脑游戏和患者随访系统,用于物理治疗和康复中的下肢肌肉强化练习
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00103
Tugba Günaydin, R. Arslan
This paper presents a low-cost rehabilitation support system for lower extremity muscle strengthening exercises: LOWER-LIMB FOLLOW-UP. The system includes two main modules: a goal-oriented serious computer game module for the patients and another that provides feedback to the physiotherapist. By analyzing the surface electromyography signals obtained from the relevant muscles of the patient, it is ensured that the patient gains points in serious computer game. The raw surface electromyography signals generated while playing the games and the result of the signal analysis are saved in the database. Feature extraction methods are used for the electromyography signal analysis. The physiotherapists can access the database via a web-based application and obtain information about their patients' performance. Muscle strengthening exercises frequently recommended, such as active knee extension exercise for quadriceps, active knee flexion exercise for hamstring and terminal extension exercise for vastus medialis obliquus muscle groups, are selected for this study.
本文提出一种低成本的下肢肌肉强化训练康复支持系统:下肢随访。该系统包括两个主要模块:一个为患者提供目标导向的严肃电脑游戏模块,另一个为物理治疗师提供反馈。通过分析患者相关肌肉的表面肌电信号,确保患者在严肃的电脑游戏中获得积分。游戏过程中产生的原始表面肌电信号和信号分析结果保存在数据库中。特征提取方法用于肌电信号分析。物理治疗师可以通过基于网络的应用程序访问数据库,并获得有关患者表现的信息。本研究选择了经常推荐的肌肉强化运动,如针对股四头肌的主动膝关节伸展运动、针对腘绳肌的主动膝关节屈曲运动和针对股内侧斜肌群的末端伸展运动。
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引用次数: 2
Towards the Analysis of How Anonymization Affects Usefulness of Health Data in the Context of Machine Learning 在机器学习的背景下,分析匿名化如何影响健康数据的有用性
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00126
Fer Carmona, J. Conesa, Jordi Casas-Roma
The volume and quality of patient data stored and collected have drastically grown in the last years. Such data can be analyzed by machine learning algorithms to improve health and well-being. However, while the distribution of data is benefitial, it should be performed in a way that preserves patient privacy. It would be expected to obtain useful information from the use of machine learning algorithms applied to both anonymized and non-anonymized datasets. However, those algorithms can generate lower quality results (even invalid ones) due to information loss during the anonymization process. We aim to analyze the relationship between anonymization and data utility/information loss, through the use of different algorithms and information loss metrics. With that aim, we plan to 1) analyze how real algorithms used on real data are affected by different anonymization techniques; 2) to use the lessons learned to design useful metrics for measuring the information loss after annonymization; and 3) to validate the proposed metrics by testing them in other environments with different types of data. The expected contributions of the research will be to obtain more information about how anonymization techniques affect the data usefulness, together with additional knowledge about the more suitable machine learning algorithms to be used to anonymized data, and a set of metrics to measure the usefulness of anonymized data would be developed
存储和收集的患者数据的数量和质量在过去几年中急剧增长。这些数据可以通过机器学习算法进行分析,以改善健康和福祉。然而,虽然数据的分发是有益的,但它应该以保护患者隐私的方式进行。预计将从应用于匿名和非匿名数据集的机器学习算法的使用中获得有用的信息。然而,由于匿名化过程中的信息丢失,这些算法产生的结果质量较低(甚至无效)。我们的目标是通过使用不同的算法和信息丢失度量来分析匿名化与数据效用/信息丢失之间的关系。为此,我们计划1)分析不同匿名化技术对真实数据上使用的真实算法的影响;2)利用经验教训设计有用的指标来衡量匿名化后的信息损失;3)通过在其他环境中使用不同类型的数据进行测试来验证所提出的度量标准。该研究的预期贡献将是获得更多关于匿名化技术如何影响数据有用性的信息,以及关于更适合用于匿名化数据的机器学习算法的额外知识,并将开发一套衡量匿名数据有用性的指标
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引用次数: 0
A Two-Phase Learning Approach for the Segmentation of Dermatological Wounds 皮肤创伤分割的两阶段学习方法
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00076
Wellington S. Silva, Daniel L. Jasbick, R. E. Wilson, P. M. A. Marques, A. Traina, Lúcio F. D. Santos, A. E. Jorge, Daniel de Oliveira, M. Bedo
Tissue segmentation in photographs of lower limb chronic ulcers is a non-intrusive approach that supports dermatological analyses. This paper presents 2PLA, a method that combines supervised and unsupervised learning strategies for enhancing the segmentation of dermatological wounds. Given an ulcer photo captured according to a fixed protocol, 2PLA first phase performs a pixelwise classification of points of interest, whereas pre-processing filters are employed for the smoothing of image noise. The cleaned image is further sent to the 2PLA divide-and-conquer second phase. It builds upon SLIC superpixel construction algorithm for dividing the lower limb into regions of interest with well-defined borders, and clusters the superpixels by taking advantage of the similarity-based DBSCAN algorithm. We set up the phases of our method by using a real annotated set of dermatological wounds, and empirical evaluations on representative samples up to 100,000 points showed a compact Multi-Layer Perceptron with Levenberg-Marquardt training algorithm (Cohen-Kappa = .971, Sensitivity = .98, and Specificity = .98) outperformed other classifiers as 2PLA first phase. Additionally, experimental trials on DBSCAN with five distance functions (L1, L2, Loo, Canberra, and BrayCurtis) indicated L1 function provided fewer groups in comparison to the competitors, and the number of clusters was an exponential decay to the similarity ratio. Accordingly, we used the elbow criterion for finding the L1-based DBSCAN threshold as 2PLA second phase parameterization. We evaluated the fine-tuned setting of our method over a labeled set of ulcer images, and wounded tissues were segmented within a .05 Mean Absolute Error ratio. These results illustrate the impact of learning parameters on 2PLA as well as the method efficacy for wound segmentation.
在下肢慢性溃疡的照片组织分割是一种非侵入性的方法,支持皮肤病学分析。本文提出了一种结合监督学习和无监督学习策略的2PLA方法,用于增强皮肤伤口的分割。给定一张根据固定方案捕获的溃疡照片,2PLA第一阶段执行感兴趣点的像素分类,而预处理滤波器用于平滑图像噪声。清洗后的图像进一步发送到2PLA分而治之的第二阶段。该算法基于SLIC超像素构建算法,将下肢划分为边界明确的感兴趣区域,并利用基于相似性的DBSCAN算法对超像素进行聚类。我们通过使用真实的皮肤伤口注释集来设置我们的方法的阶段,并对代表样本进行了多达100,000个点的经验评估,结果表明使用Levenberg-Marquardt训练算法的紧凑多层感知器(cohn - kappa = .971,灵敏度= .98,特异性= .98)优于其他分类器作为2PLA第一阶段。此外,在具有5个距离函数(L1、L2、Loo、Canberra和BrayCurtis)的DBSCAN上进行的实验试验表明,与竞争对手相比,L1函数提供的组更少,并且簇的数量呈指数衰减。因此,我们使用肘部准则来寻找基于l1的DBSCAN阈值作为2PLA第二阶段参数化。我们在一组标记的溃疡图像上评估了我们方法的微调设置,受伤组织在0.05的平均绝对错误率内被分割。这些结果说明了学习参数对2PLA的影响以及该方法在伤口分割中的有效性。
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引用次数: 6
Assessing K-Nearest Neighbours Algorithm for Simple, Interpretable Time-to-Event Survival Predictions Over a Range of Simulated Datasets 在一系列模拟数据集上评估简单的、可解释的时间到事件生存预测的k近邻算法
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00080
P. Kroupa, Caroline Morton, K. L. Calvez, Matt Williams
Survival prediction is a key task in medicine. Existing models are based on statistical techniques, such as the Cox models and there is limited work on the application of machine learning. In this paper we demonstrate that the K-Nearest Neighbour algorithm can be used for survival prediction. We show that its performance is as good as that of standard techniques, and that it provides a clear interpretation of the results. We show that pre-processing methods improve performance, and evaluate the performance across 20 different datasets with differing properties to show that the model performs well under various conditions. For low event rate datasets we show that KNN can outperform the Cox model.
生存预测是医学中的一项关键任务。现有的模型是基于统计技术,如Cox模型,机器学习的应用工作有限。在本文中,我们证明了k近邻算法可以用于生存预测。我们证明它的性能与标准技术一样好,并且它提供了对结果的清晰解释。我们证明了预处理方法提高了性能,并在20个不同属性的不同数据集上评估了性能,以表明该模型在各种条件下都表现良好。对于低事件率数据集,我们表明KNN可以优于Cox模型。
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引用次数: 0
Developing a Data Infrastructure for Enabling Breast Cancer Women to BOUNCE Back 开发一个数据基础设施,使乳腺癌妇女反弹
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00134
H. Kondylakis, L. Koumakis, Dimitrios G. Katehakis, A. Kouroubali, K. Marias, M. Tsiknakis, P. Simos, E. Karademas
Breast cancer is the most common cancer disease in women and is rapidly becoming a chronic illness due recent advances in treatment methods. As such, coping with cancer has become a major socio-economic challenge leading to an increasing need for predicting resilience of women to the variety of stressful experiences and practical challenges they face. In this paper, we present the data infrastructure developed for this purpose, demonstrating the various components that will contribute to the developing the resilience trajectory predictor. Special emphasis is given to the semantic tier, presenting the project solution already implemented for effectively collecting, ingesting, cleaning, modelling and processing data that will be used throughout the lifetime of the project.
乳腺癌是妇女中最常见的癌症疾病,由于最近治疗方法的进步,它正迅速成为一种慢性病。因此,应对癌症已成为一项重大的社会经济挑战,导致越来越需要预测女性对各种压力经历和实际挑战的适应能力。在本文中,我们提出了为此目的开发的数据基础设施,展示了将有助于开发弹性轨迹预测器的各种组件。特别强调了语义层,展示了已经实现的项目解决方案,用于有效地收集、摄取、清理、建模和处理将在整个项目生命周期中使用的数据。
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引用次数: 15
Efficient Hyperparameter Optimization of Convolutional Neural Networks on Classification of Early Pulmonary Nodules 卷积神经网络在早期肺结节分类中的高效超参数优化
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00039
Lucas L. Lima, J. Ferreira, M. C. Oliveira
Lung cancer is the leading cause of cancer mortality, accounting for approximately 20% of all cancer-related deaths. Patients diagnosed in the early stages have a 1-year survival rate of 81-85% while in an advanced stage have 15-19% chances of survival. Therefore, it is very necessary to diagnose lung cancer in early stages in malignant or benign, when the nodules are still very small, but it is a complex task even for experienced specialists and presents some challenges. To assist specialists, computer-aided diagnosis systems have been used to improve the accuracy in the diagnosis. In this paper, we exploit the use of a technique of hyperparameter tuning to find the best architecture of a Convolutional Neural Network to classify small pulmonary nodules balanced with diameter 5-10mm. The best results achieved were an error rate of 12%, sensitivity of 94%, specificity of 83%, accuracy of 88% and F-measure of 89%
肺癌是癌症死亡的主要原因,约占所有癌症相关死亡的20%。早期诊断的患者1年生存率为81-85%,而晚期患者的生存率为15-19%。因此,早期诊断肺癌是非常必要的,无论是恶性还是良性,此时的结节还很小,但即使是经验丰富的专家,这也是一项复杂的任务,并且存在一些挑战。为了协助专家,计算机辅助诊断系统已被用于提高诊断的准确性。在本文中,我们利用超参数调谐技术来寻找卷积神经网络的最佳架构,以分类直径为5-10mm的小肺结节。最佳结果为错误率为12%,灵敏度为94%,特异性为83%,准确度为88%,F-measure为89%
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引用次数: 7
Using Acceleration Data for Detecting Temporary Cognitive Overload in Health Care Exemplified Shown in a Pill Sorting Task 在医疗保健中使用加速数据检测暂时性认知超载的例子显示在一个药丸分类任务中
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00015
L. Kohout, Manuel Butz, W. Stork
In this paper we propose a new approach for detecting temporary cognitive overload. Due to the raising propagation of wearable devices with various integrated sensors, the idea is to detect such overload situations based on acceleration data out of these sensors at task relevant body parts. We executed an experiment in order to investigate the performance differences of people in a relaxed state and under cognitive load. The loaded state was simulated in a dual-task test. Additionally, we analyzed changes in the participants' motion behaviors at their hips and both of their wrists. We could show, that dual-task measuring is a suitable way for generating ground truth data for cognitive load. For this reason we used the study's data also as ground truth for the subsequent developed classification system. After investigating different features from the data we could discriminate the two states ("relaxed" and "loaded") with an accuracy of 90% and an MCC of 0.7986, which indicates a high correlation between ground truth and classified data. That outperforms other ACC based systems and approaches the performance of vital parameter based ones. Moreover, it could be shown that the dominant hand's data have greater influence to the results than the recessive one's. However, using data from both hands leads to further improvements.
本文提出了一种检测暂时性认知超载的新方法。由于集成了各种传感器的可穿戴设备的传播速度越来越快,我们的想法是根据这些传感器在任务相关身体部位的加速度数据来检测这种过载情况。我们进行了一项实验,以研究人们在放松状态和认知负荷下的表现差异。在双任务测试中模拟加载状态。此外,我们还分析了参与者臀部和双手腕运动行为的变化。我们可以证明,双任务测量是为认知负荷生成真实数据的合适方法。出于这个原因,我们也使用了研究的数据作为后续开发的分类系统的基础事实。在研究了数据的不同特征后,我们可以区分两种状态(“放松”和“加载”),准确率为90%,MCC为0.7986,这表明地面真实值与分类数据之间具有很高的相关性。这优于其他基于ACC的系统,并接近基于关键参数的系统的性能。此外,显性手的数据比隐性手的数据对结果的影响更大。然而,使用双手的数据会带来进一步的改进。
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引用次数: 2
Transforming Unstructured Clinical Free-Text Corpora into Reconfigurable Medical Digital Collections 将非结构化的临床自由文本语料库转化为可重构的医学数字馆藏
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00105
F. Buendía, Joaquín Gayoso-Cabada, J. A. J. Méndez, J. Sierra
In this paper, we describe how to transform unstructured free-text clinical corpora, made from reports written in natural language and complementary assets (e.g., medical images, laboratory results, etc.), into collections of digital objects compatible with Clavy, a tool for managing reconfigurable digital collections. It will allow healthcare experts to subsequently reorganize the resulting collections to adapt them to their specific needs. The transformation will be achieved through the use of MetaMap, a robust tool for mapping clinical texts into the UMLS (Unified Medical Language System) thesaurus. Thus, by processing reports with MetaMap, we will be able to extract a significant set of corpus-specific UMLS terms, grouped according to relevant semantic types, which will be used to support a preliminary organization of the resources in the Clavy collection. We illustrate the viability of the approach with the generation of a reconfigurable Clavy collection from the Indiana Chest X-ray corpus of radiology reports and images. On the basis of this case study, we also discuss the strengths and weaknesses of the approach proposed.
在本文中,我们描述了如何将非结构化的自由文本临床语料库(由用自然语言编写的报告和补充资产(例如,医学图像,实验室结果等)组成)转换为与Clavy兼容的数字对象集合,Clavy是一种管理可重构数字集合的工具。它将允许医疗保健专家随后重新组织产生的集合,以适应他们的具体需求。这种转换将通过使用MetaMap来实现,MetaMap是一个强大的工具,用于将临床文本映射到UMLS(统一医学语言系统)词典中。因此,通过使用MetaMap处理报告,我们将能够提取一组重要的特定于语料库的UMLS术语,根据相关的语义类型进行分组,这些术语将用于支持Clavy集合中资源的初步组织。我们通过从印第安纳州胸部x射线报告和图像的语料库生成可重构的Clavy集合来说明该方法的可行性。在此案例研究的基础上,我们还讨论了所提出的方法的优点和缺点。
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引用次数: 4
Action Recognition in Real Homes using Low Resolution Depth Video Data 使用低分辨率深度视频数据的真实家庭中的动作识别
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00041
F. D. Casagrande, O. O. Nedrejord, Wonho Lee, E. Zouganeli
We report work in progress from interdisciplinary research on Assisted Living Technology in smart homes for older adults with mild cognitive impairments or dementia. We present our field trial, the set-up for collecting and storing data from real homes, and preliminary results on action recognition using low resolution depth video cameras. The data have been collected from seven apartments with one resident each over a period of two weeks. We propose a pre-processing of the depth videos by applying an Infinite Response Filter (IIR) for extracting the movements in the frames prior to classification. In this work we classify four actions: TV interaction (turn it on/ off and switch over), standing up, sitting down, and no movement. Our first results indicate that using the IIR filter for movement information extraction improves accuracy and can be an efficient method for recognizing actions. Our current implementation uses a convolutional long short-term memory (ConvLSTM) neural network, and achieved an average peak accuracy of 86%.
我们报告了智能家居中辅助生活技术的跨学科研究进展,该技术适用于患有轻度认知障碍或痴呆症的老年人。我们展示了我们的现场试验,收集和存储真实家庭数据的设置,以及使用低分辨率深度摄像机进行动作识别的初步结果。这些数据是在七套公寓中收集的,每套公寓有一名居民,为期两周。我们提出了一种深度视频的预处理方法,通过应用无限响应滤波器(IIR)在分类之前提取帧中的运动。在这项工作中,我们将四种动作分类为:电视互动(打开/关闭和切换),站起来,坐下和不动。我们的第一个结果表明,使用IIR滤波器提取运动信息提高了准确性,可以成为一种有效的动作识别方法。我们目前的实现使用卷积长短期记忆(ConvLSTM)神经网络,并实现了86%的平均峰值准确率。
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引用次数: 3
Towards Automated Smart Mobile Crowdsensing for Tinnitus Research 面向耳鸣研究的自动化智能移动众测
Pub Date : 2019-06-05 DOI: 10.1109/CBMS.2019.00026
Muntazir Mehdi, Denis Schwager, R. Pryss, W. Schlee, M. Reichert, F. Hauck
Tinnitus is a disorder that is not entirely understood, and many of its correlations are still unknown. On the other hand, smartphones became ubiquitous. Their modern versions provide high computational capabilities, reasonable battery size, and a bunch of embedded high-quality sensors, combined with an accepted user interface and an application ecosystem. For tinnitus, as for many other health problems, there are a number of apps trying to help patients, therapists, and researchers to get insights into personal characteristics but also into scientific correlations as such. In this paper, we present the first approach to an app in this context, called TinnituSense that does automatic sensing of related characteristics and enables correlations to the current condition of the patient by a combined participatory sensing, e.g., a questionnaire. For tinnitus, there is a strong hypothesis that weather conditions have some influence. Our proof-of-concept implementation records weather-related sensor data and correlates them to the standard Tinnitus Handicap Inventory (THI) questionnaire. Thus, TinnituSense enables therapists and researchers to collect evidence for unknown facts, as this is the first opportunity to correlate weather to patient conditions on a larger scale. Our concept as such is limited neither to tinnitus nor to built-in sensors, e.g., in the tinnitus domain, we are experimenting with mobile EEG sensors. TinnituSense is faced with several challenges of which we already solved principle architecture, sensor management, and energy consumption.
耳鸣是一种尚未完全了解的疾病,其许多相关性仍然未知。另一方面,智能手机变得无处不在。它们的现代版本提供了高计算能力、合理的电池尺寸和一堆嵌入式高质量传感器,并结合了公认的用户界面和应用生态系统。对于耳鸣,就像许多其他健康问题一样,有许多应用程序试图帮助患者、治疗师和研究人员了解个人特征,同时也了解科学相关性。在本文中,我们提出了在此背景下的第一种应用方法,称为TinnituSense,它可以自动感知相关特征,并通过联合参与式感知(例如问卷调查)实现与患者当前状况的相关性。对于耳鸣,有一个强有力的假设,天气条件有一些影响。我们的概念验证实现记录了与天气相关的传感器数据,并将其与标准耳鸣障碍清单(THI)问卷相关联。因此,TinnituSense使治疗师和研究人员能够收集未知事实的证据,因为这是第一次有机会在更大范围内将天气与患者状况联系起来。我们的概念既不局限于耳鸣也不局限于内置传感器,例如,在耳鸣领域,我们正在试验移动脑电图传感器。TinnituSense面临着几个挑战,我们已经解决了原理架构,传感器管理和能耗。
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引用次数: 9
期刊
2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)
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