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2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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Breast Density Classification using Local Septenary Patterns: A Multi-resolution and Multi-topology Approach 使用局部七层模式的乳腺密度分类:多分辨率和多拓扑方法
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00133
Andrik Rampun, B. Scotney, P. Morrow, Haibo Wang
We present an extension of our previous work in [1] by investigating the use of Local Septenary Patterns (LSP) for breast density classification in mammograms. The LSP operator is a variant of Local Binary Patterns (LBP) inspired by Local Ternary Patterns (LTP) and Local Quinary patterns (LQP). The main extensions in our work are i) we investigate the use of a multi-resolution technique when extracting micro texture information, ii) we investigate different neighbourhood topologies as different ways of extracting texture features, and iii) we use an additional dataset called InBreast as well as the most popular dataset in the literature, which is the Mammographic Image Analysis Society (MIAS) to further evaluate the performance of the LSP operator.
我们通过研究在乳房x线照片中使用局部七区模式(LSP)进行乳房密度分类,提出了我们在[1]中先前工作的扩展。LSP算子是受本地三元模式(LTP)和本地五元模式(LQP)启发的本地二元模式(LBP)的一种变体。我们工作的主要扩展是i)我们研究了在提取微纹理信息时使用多分辨率技术,ii)我们研究了不同的邻域拓扑作为提取纹理特征的不同方法,以及iii)我们使用了一个名为InBreast的额外数据集以及文献中最流行的数据集,即乳腺图像分析协会(MIAS),以进一步评估LSP算子的性能。
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引用次数: 5
Generating and Evaluating Synthetic UK Primary Care Data: Preserving Data Utility & Patient Privacy 生成和评估综合英国初级保健数据:保护数据效用和患者隐私
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00036
Zhenchen Wang, P. Myles, A. Tucker
There is increasing interest in the potential of synthetic data to validate and benchmark machine learning algorithms as well as reveal any biases in real-world data used for algorithm development. This paper discusses the key requirements of synthetic data for such purposes and proposes an approach to generating and evaluating synthetic data that meets these requirements. We propose a framework to generate and evaluate synthetic data with the aim of simultaneously preserving the complexities of ground truth data in the synthetic data whilst also ensuring privacy. We include as a case study, a proof-of-concept synthetic dataset modelled on UK primary care data to demonstrate the application of this framework.
人们越来越关注合成数据的潜力,以验证和基准机器学习算法,以及揭示用于算法开发的现实世界数据中的任何偏差。本文讨论了用于此类目的的合成数据的关键要求,并提出了一种生成和评估满足这些要求的合成数据的方法。我们提出了一个框架来生成和评估合成数据,目的是同时保留合成数据中地面真实数据的复杂性,同时确保隐私。作为一个案例研究,我们包括了一个概念验证合成数据集,以英国初级保健数据为模型,以展示该框架的应用。
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引用次数: 25
Mobile Conversational Agents for Stroke Rehabilitation Therapy 卒中康复治疗的移动会话代理
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00104
D. Griol, Zoraida Callejas Carrión
Mobile health (m-Health) has emerged as a rapidly developing area that is transforming clinical research and health care on a global scale. In this paper, we describe a conversational app for the therapy of stroke rehabilitation. The main objective of the conversational app is to help recovering cognitive abilities of patients by means of a set of proposed exercises, which are divided into 8 categories focused on specific abilities. These categories have been defined after a detailed review of the guidelines for rehabilitation and training therapies. In addition, the application integrates a multimodal conversational interface to facilitate human-computer interaction, which has been specially designed for the elderly and patients with motor or visual or disabilities. The exercises provided by the application can be easily adapted to the specific users' requirements and preferences by means of the incorporation, deletion or modification of routines stored into a specific database isolated from the logic of the application.
移动医疗(m-Health)已成为一个迅速发展的领域,正在全球范围内改变临床研究和卫生保健。在本文中,我们描述了一个会话应用程序的治疗中风康复。这款对话应用的主要目标是通过一组建议的练习来帮助患者恢复认知能力,这些练习分为8类,重点关注特定的能力。这些类别是在对康复和训练疗法的指导方针进行详细审查后确定的。此外,该应用程序集成了一个多模式对话界面,以促进人机交互,这是专门为老年人和有运动或视觉障碍或残疾的患者设计的。通过合并、删除或修改存储在与应用程序逻辑隔离的特定数据库中的例程,应用程序提供的练习可以很容易地适应特定用户的需求和偏好。
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引用次数: 4
Improving Interpretable Prediction Models for Antimicrobial Resistance 改进抗菌素耐药性可解释预测模型
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00111
B. Cánovas-Segura, Antonio Morales Nicolás, Antonio López Martínez-Carrasco, M. Campos, J. Juarez, L. López-Rodríguez, Francisco Palacios Ortega
One of the major problems of healthcare institutions is the treatment of infections caused by bacteria that are resistant to antimicrobials. The early prediction of such infections can improve the patient's evolution as well as minimise the spread of antimicrobial resistance. The creation of effective prediction models is particularly limited due to the high dimensionality of data, the imbalanced datasets and the concept drift problem. In this paper, we face these challenges from a machine learning perspective, considering the interpretability of the resulting models as essential. In particular, we present a study of multiple techniques focused on the mitigation of these problems, that are used in combination with interpretable models. Our results indicate that the use of oversampling along with sliding windows can improve the resulting AUC of models (up to reaching a mean AUC of 0.80 in our dataset), and FCBF can be used to drastically reduce the number of predictors, obtaining simpler models with a slight AUC reduction (from a mean number of predictors of 69.78 to 16.28, achieving a mean AUC of 0.76). According to our results, we show that the combination of multiple techniques for dealing with the aforementioned data-mining problems can clearly improve the performance of prediction models for antimicrobial resistance.
卫生保健机构的主要问题之一是治疗对抗菌素具有耐药性的细菌引起的感染。这种感染的早期预测可以改善患者的进化,并尽量减少抗菌素耐药性的传播。由于数据的高维、数据集的不平衡和概念漂移问题,有效预测模型的创建尤其受到限制。在本文中,我们从机器学习的角度来面对这些挑战,考虑到结果模型的可解释性是必不可少的。特别地,我们提出了一项针对缓解这些问题的多种技术的研究,这些技术与可解释模型结合使用。我们的研究结果表明,使用过采样和滑动窗口可以提高模型的AUC(在我们的数据集中达到0.80的平均AUC), FCBF可以大大减少预测器的数量,获得更简单的模型,AUC略有减少(从平均预测器数量69.78到16.28,实现平均AUC为0.76)。根据我们的研究结果,我们表明,结合多种技术来处理上述数据挖掘问题可以明显提高抗菌素耐药性预测模型的性能。
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引用次数: 4
UCORM: Indexing Uncorrelated Metric Spaces for Concise Content-Based Retrieval of Medical Images UCORM:索引不相关度量空间,用于简洁的基于内容的医学图像检索
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00070
Guilherme F. Zabot, M. Cazzolato, L. C. Scabora, Bruno S. Faiçal, A. Traina, C. Traina
The large amount of medical exams generated by hospitals has a great potential to boost the support for physicians on decision making tasks. This requires efficient and reliable computational systems to retrieve relevant information in real-time. Existing Content-Based Image Retrieval (CBIR) systems rely on Metric Access Methods (MAMs) to speed-up the retrieval task. In this context, images are represented by Feature Extraction Methods (FEMs), according to information such as color or texture. However, MAMs usually index images based on a single FEM. Whenever physicians want to search for similar images using multiple FEMs simultaneously, they need to perform separated queries. In this work, we propose UCORM, an access method capable of indexing images using multiple FEMs by overlapping different metric spaces. UCORM selects the best FEMs to generate a concise yet accurate indexing space. It relies on an interesting use of Pearson correlation, that we named PCMS, to compute the correlation between different FEMs. PCMS allows UCORM to improve the retrieval task by minimizing the overlapping between metric spaces, resulting on fewer intermediary images when performing a query. Experimental analysis shows that UCORM prunes well the data distribution regions with low correlation between FEMs. Also, two medical application scenarios support our claim that UCORM is well-fitted for clinical environments.
医院产生的大量医学检查具有极大的潜力,可以提高医生对决策任务的支持。这就需要高效可靠的计算系统来实时检索相关信息。现有的基于内容的图像检索(CBIR)系统依赖度量访问方法(MAMs)来加快检索任务。在这种情况下,图像是由特征提取方法(fem)表示,根据信息,如颜色或纹理。然而,MAMs通常基于单个FEM对图像进行索引。当医生想要同时使用多个fem搜索相似的图像时,他们需要执行分离的查询。在这项工作中,我们提出了UCORM,一种能够通过重叠不同度量空间来索引使用多个fem的图像的访问方法。UCORM选择最好的fem来生成简洁而准确的索引空间。它依赖于一个有趣的使用Pearson相关性,我们称之为PCMS,来计算不同fem之间的相关性。PCMS允许UCORM通过最小化度量空间之间的重叠来改进检索任务,从而在执行查询时减少中间图像。实验分析表明,UCORM很好地修剪了fem之间相关性较低的数据分布区域。此外,两个医疗应用场景支持我们的说法,即UCORM非常适合临床环境。
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引用次数: 3
Osteoporosis Classification Using Texture Features 骨质疏松症的纹理特征分类
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00119
F. Riaz, R. Nemati, Hina Ajmal, Ali Hassan, E. Edifor, R. Nawaz
Assessment of osteoporotic disease from the radiograph image is a significant challenge. Texture characteristics when observed from the naked eye for the bone microarchitecture of the osteoporotic and healthy cases are visually very similar making it a challenging classification problem. To extract the discriminative patterns in all the orientations and scales simultaneously in this study we have proposed an approach that is based on a combination of multi resolution Gabor filters and 1D local binary pattern (1DLBP) features. Gabor filter are used due to their advantages in yielding a scale and orientation sensitive analysis whereas LBPs are useful for quantifying microstructural changes in the images. Our experiment show that the proposed method shows good classification results with an overall accuracy of about 72.71% and outperforms the other methods that have been considered in this paper.
从x线影像评估骨质疏松症是一个重大挑战。骨质疏松和健康病例的骨微结构的纹理特征在视觉上非常相似,这是一个具有挑战性的分类问题。为了同时提取所有方向和尺度上的判别模式,本研究提出了一种基于多分辨率Gabor滤波器和1D局部二元模式(1DLBP)特征相结合的方法。Gabor滤波器由于其在产生尺度和方向敏感分析方面的优势而被使用,而lbp对于量化图像中的微观结构变化是有用的。实验表明,该方法分类效果良好,总体准确率约为72.71%,优于本文所考虑的其他方法。
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引用次数: 4
A Dynamic Behavioral Approach to Nutritional Assessment using Process Mining 利用过程挖掘的动态行为方法进行营养评估
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00085
Zoe Valero-Ramon, C. Fernández-Llatas, A. Martínez-Millana, V. Traver
Malnutrition is one of the major geriatric syndromes and frailty factor, this joint with the fact of elderly population growing, will situate malnutrition as a front end problem in the upcoming years. Therefore, it is important that health professionals can assess and follow up nutritional status in a proper way, using all available data related to patients. Process mining can be used to extract knowledge from information in order to understand health care processes. A classic approach to assess malnutrition usually comprises anthropometric measures as static variables, with no information about patients evolution and pathways. The aim of this work was to examine anthropometric measures from a dynamic perspective thanks to process mining tools, in order to obtain dynamic behaviour models. This paper proposes a method based on the use of process mining to discover and identify weight changes behaviour. Clustering is used as part of the pre-processing of data to manage variability, and then process mining is used to identify patterns of patients' behaviour. The method is applied through different experiments to data from 96 patients. Results grouped almost all individuals in different models based on common behaviours. Main finding shows different behaviour groups seem to have different results regarding malnutrition status for same interventions. By discovering patterns of dynamic weight change and their relation with malnutrition, nursing homes and health care professional can promote more successful intervention among patients based on their behaviour, moreover they can compare interventions' results analysing changes in behaviour between before and after the intervention.
营养不良是主要的老年综合征和衰弱因素之一,再加上老年人口的增长,营养不良将成为未来几年的一个前沿问题。因此,重要的是卫生专业人员能够利用与患者有关的所有可用数据,以适当的方式评估和跟踪营养状况。流程挖掘可用于从信息中提取知识,以便了解医疗保健流程。评估营养不良的经典方法通常包括人体测量作为静态变量,没有关于患者进化和途径的信息。这项工作的目的是通过过程挖掘工具从动态角度检查人体测量,以获得动态行为模型。本文提出了一种基于过程挖掘的权重变化行为发现和识别方法。聚类被用作数据预处理的一部分来管理可变性,然后使用过程挖掘来识别患者的行为模式。该方法通过不同的实验应用于96例患者的数据。结果将几乎所有的个体根据共同的行为分组在不同的模型中。主要发现表明,不同行为群体对相同干预措施的营养不良状况似乎有不同的结果。通过发现动态体重变化的模式及其与营养不良的关系,养老院和保健专业人员可以根据患者的行为促进更成功的干预,而且他们可以比较干预的结果,分析干预前后的行为变化。
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引用次数: 7
Retinal OCT Segmentation Using Fuzzy Region Competition and Level Set Methods 基于模糊区域竞争和水平集方法的视网膜OCT分割
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00029
B. I. Dodo, Yongmin Li, A. Tucker, Djibril Kaba, Xiaohui Liu
Optical coherence tomography (OCT) is a noninvasive imaging modality that provides in-depth images of the retina. Properties of individual layers on OCT have become important markers for diagnosing and tracking medication of various eye diseases in current ophthalmology. Manual segmentation of OCT scans posed many challenges (errors, inconsistency), which can be addressed by automated segmentation methods. Level set method is one of the most popular methods in the literature used for this purpose. Although level set methods have a fundamental way of handling topological changes, the weak boundaries and noise in addition to inhomogeneity in OCT images make it difficult to segment the layers accurately. Inspired by the concept of region competition, we incorporate prior knowledge of the retinal structure to segment nine (9) layers of the retina. Mainly, we establish a specific region of interest, then use selected components from fuzzy C-Means for initialisation. The clustering in the initialisation stage is also used to guide the evolution through; a Mumford-Shah (MS) selective region competition force and a Hamilton-Jacobi (HJ) balloon force. The forces ensure evolution close to actual retinal boundaries. Finally, the convergence of the method is based on an improved HJ object indication function influenced by the fuzzy membership to prevent leakages at weak boundaries. Experimental results are promising based on 200 OCT images.
光学相干断层扫描(OCT)是一种非侵入性成像方式,可提供视网膜的深度图像。OCT各层的性质已成为当今眼科诊断和跟踪各种眼病用药的重要标志。手动分割OCT扫描带来了许多挑战(错误,不一致),这些可以通过自动分割方法解决。水平集方法是文献中用于此目的的最流行的方法之一。虽然水平集方法具有处理拓扑变化的基本方法,但OCT图像中的弱边界和噪声以及非均匀性使得难以准确分割层。受区域竞争概念的启发,我们结合视网膜结构的先验知识来分割视网膜的九层。主要是建立一个特定的兴趣区域,然后使用从模糊c均值中选择的分量进行初始化。初始化阶段的聚类也用于指导进化;Mumford-Shah (MS)选择性区域竞争力和Hamilton-Jacobi (HJ)气球力。这些力确保进化接近实际的视网膜边界。最后,利用模糊隶属度影响的改进HJ目标指示函数来防止弱边界处的泄漏,从而达到收敛性。基于200张OCT图像的实验结果是有希望的。
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引用次数: 11
European Genome-Phenome Archive (EGA) - Granular Solutions for the Next 10 Years 欧洲基因组-表型档案(EGA) -未来10年的颗粒解决方案
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00011
D. Fernández-Orth, Audald Lloret-Villas, Jordi Rambla De Argila
The European Genome-phenome Archive (EGA) is a repository that facilitates access and management for long-term archival of human biomolecular data. The EGA is co-managed by the European Bioinformatics Institute (EBI) and the Centre for Genomic Regulation (CRG). As the omics community awareness of data sharing and reproducibility increases, complex services and granular solutions are needed from the repositories such as EGA. Not only will we introduce the EGA environment but we will also present advanced features designed for a wide range of users. These new tools and technologies include the EGA Beacon (developed within the GA4GH and ELIXIR framework), infrastructures for data access and retrieval, as well as data quality control and visualisation projects.
欧洲基因组-表型档案(EGA)是一个存储库,便于访问和管理人类生物分子数据的长期档案。EGA由欧洲生物信息学研究所(EBI)和基因组调控中心(CRG)共同管理。随着组学社区对数据共享和可再现性的认识的提高,需要来自诸如EGA之类的存储库的复杂服务和粒度解决方案。我们不仅会介绍EGA环境,还会介绍为广大用户设计的高级功能。这些新工具和技术包括EGA Beacon(在GA4GH和ELIXIR框架内开发),数据访问和检索基础设施,以及数据质量控制和可视化项目。
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引用次数: 1
Predicting the Heart Rate Response to Outdoor Running Exercise 预测户外跑步运动的心率反应
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00052
Xiaoli Liu, Xiang Su, S. Tamminen, Topi Korhonen, J. Röning
Heart rate is a good measure for physical exercise as it accurately reflects exercise intensity and is easy to measure. If the heart rate response to a complete exercise session is predicted beforehand, information related to the exercise can be inferred, such as exercise intensity and calorie consumption. While most current heart rate prediction models are developed and tested for the scenarios of indoor running exercise or low running speed exercise, we adopt a nonlinear Ordinary Differential Equation (ODE) model for complete outdoor running exercise sessions to predict the heart rate response and identify the parameters of the model with machine learning algorithms. The proposed model enables us to predict a complete outdoor running exercise session instead of predicting the heart rate for a short duration. Model validation is carried out both on the training and testing sets. Our results show that the proposed model captures very stable prediction performance.
心率是衡量体育锻炼的一个很好的指标,因为它能准确地反映运动强度,而且易于测量。如果事先预测到完整运动过程中的心率反应,就可以推断出与运动有关的信息,如运动强度和卡路里消耗。虽然目前大多数心率预测模型都是针对室内跑步运动或低跑步速度运动的场景开发和测试的,但我们采用非线性常微分方程(ODE)模型来预测完整的户外跑步运动时段的心率反应,并使用机器学习算法识别模型的参数。所提出的模型使我们能够预测一个完整的户外跑步锻炼时段,而不是预测短时间内的心率。在训练集和测试集上对模型进行验证。结果表明,该模型具有非常稳定的预测性能。
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引用次数: 2
期刊
2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS)
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