Food and Chemical Toxicology最新文献_第10页

Probabilistic exposure assessment and risk characterization of quinolizidine alkaloids and phomopsin A in the Belgian population 比利时人群喹诺齐啶类生物碱和视光素A的概率暴露评估和风险表征。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-22 DOI: 10.1016/j.fct.2025.115812

Sofie Schryvers , Bram Miserez , Mia Eeckhout , Liesbeth Jacxsens

Lupins are gaining popularity in EU diets as a source of plant-based proteins. They may, however, contain high levels of quinolizidine alkaloids (QAs) and are prone to contamination with phomopsins (PHO). The associated food safety risks remain unclear. To fill the gap in consumption data of lupins and lupin-derived foods, a Food Frequency Questionnaire (FFQ) was developed and used to survey 535 Belgian respondents. The acute dietary exposure to total QAs (TQAs), as the sum of seven QAs, was modeled using a second order Monte Carlo simulation framework. Food safety risks were characterized for consumers across 12 product categories using a margin of exposure (MOE) approach. MOE values below 1, indicating a potential acute food safety risk, were obtained for the consumers of lupin seeds and flour, and the P95 of consumers of jarred lupins. An average chronic exposure to QAs and PHO A of 7.4 ± 26.8 μg/kg bw/d and 5.3 ± 3.9 ng/kg bw/d, respectively, was derived for the consumers of lupin-containing foods in an upper-bound scenario. These findings support the need for risk management measures to control QAs in lupins, particularly in dry seeds. Additional occurrence and toxicity data are required for a health risk assessment of PHO A.

羽扇豆作为植物性蛋白质的来源，在欧盟饮食中越来越受欢迎。然而，它们可能含有高水平的喹诺嗪类生物碱（QAs），并且容易被磷磷脂（PHO）污染。相关的食品安全风险仍不清楚。为了填补羽扇豆素和羽扇豆素衍生食品消费数据的空白，开发了一份食物频率问卷（FFQ），并对535名比利时受访者进行了调查。采用二阶蒙特卡罗模拟框架，对7种总脂肪酸（TQAs）的急性膳食暴露量进行建模。使用暴露边际（MOE）方法对12种产品类别的消费者进行食品安全风险表征。食用罗苹籽和面粉的消费者的MOE值低于1，表明存在潜在的急性食品安全风险，食用罐装罗苹豆的消费者的P95值低于1。在上限情景下，含羽扇豆素食品的消费者对QAs和PHO A的平均慢性暴露量分别为7.4±26.8 μg/kg bw/d和5.3±3.9 ng/kg bw/d。这些发现支持需要采取风险管理措施来控制羽扇豆中的QAs，特别是在干种子中。对PHO a的健康风险评估需要更多的发生率和毒性数据。

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引用次数: 0

Arecoline stimulates the IL-33/13 axis and upregulates pro-fibrotic CTGF: A possible role in oral submucous fibrosis 槟榔碱刺激IL-33/13轴并上调促纤维化CTGF：在口腔黏膜下纤维化中的可能作用

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-22 DOI: 10.1016/j.fct.2025.115811

Pan Kit Chan , Ashley Keyes , Selene Papanastasiou , Babak Sarrafpour , Yogambha Ramaswamy , Stephen Co , Hans Zoellner , Belal Chami

Areca nut chewing is a culturally significant practice shown to cause Oral Submucous Fibrosis (OSMF), which has a high potential for morbidity and malignancy. We postulate that arecoline upregulates production of pro-fibrotic cytokines, IL-33 and IL-13 and aimed to assess both IL-33/IL-13 expression and extracellularisation during arecoline treatment in human gingival fibroblasts (HGF) and mast cells, respectively. Primary HGF cells were exposed to increasing concentrations of arecoline (0 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL, 200 μg/mL) under serum starvation conditions for 16 h. Co-culture transwell systems were used to examine arecoline-induced synergic activation of mast cells. We observed that 100 μg/mL and 200 μg/mL of arecoline is sufficient to induce significant levels of cell toxicity and death, with concurrent release of both pro-fibrotic factor, CTGF and IL-33 from HGF cells and IL-13 from mast cells. We are the first to report that arecoline induces release of IL-13, mast cell degranulation, and increased soluble CTGF. In conclusion, arecoline induces IL-33, IL-13 and CTGF release in HGF and mast cells, highlighting the importance of the IL-33/IL-13 axis in the progressive fibrosis of OSMF. These findings could support the approach of novel therapies targeting the IL-33/IL-13 axis for patients with OSMF.

咀嚼槟榔是一种文化上重要的做法，被证明会导致口腔粘膜下纤维化（OSMF），这有很高的发病率和恶性肿瘤的可能性。我们假设槟榔碱上调促纤维化细胞因子IL-33和IL-13的产生，并旨在分别评估槟榔碱在人牙龈成纤维细胞（HGF）和肥大细胞中的IL-33/IL-13表达和细胞外化。将原代HGF细胞在血清饥饿条件下暴露于浓度增加的槟榔碱（0 μg/mL、25 μg/mL、50 μg/mL、100 μg/mL、200 μg/mL）中16 h。采用共培养transwell系统检测槟榔碱对肥大细胞的协同活化作用。我们观察到100 μg/mL和200 μg/mL槟榔碱足以诱导显著水平的细胞毒性和死亡，HGF细胞同时释放促纤维化因子、CTGF和IL-33，肥大细胞同时释放IL-13。我们首次报道槟榔碱诱导IL-13的释放、肥大细胞脱颗粒和可溶性CTGF的增加。综上所述，槟油酚可诱导HGF和肥大细胞释放IL-33、IL-13和CTGF，提示IL-33/IL-13轴在OSMF进行性纤维化中的重要作用。这些发现可能支持针对IL-33/IL-13轴治疗OSMF患者的新疗法。

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引用次数: 0

Glycoalkaloids in potatoes: exploring health effects, analytical techniques, occurrence, mitigation measures 马铃薯中的糖生物碱：探讨对健康的影响、分析技术、发生、缓解措施。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-17 DOI: 10.1016/j.fct.2025.115807

João Gonçalves Figueira , Sílvia Cruz Barros , Estefania Valero-Cases , Ana Sanches Silva

Glycoalkaloids are secondary metabolites naturally synthesized by potatoes that can become toxic when present in when present above a certain level. Given that potatoes are one of the most widely consumed foods globally, it is essential to develop evaluation and analysis methods capable of controlling these compounds and optimizing the conditions that positively influence their concentration in tubers. Various factors, from agricultural practices during potato cultivation to storage and commercial distribution conditions can influence glycoalkaloids and may result in toxic levels. Therefore, it is crucial to apply techniques that preserve the quality of potatoes without compromising their safety. While glycoalkaloids are primarily known for their toxicity and adverse effects on human health, they have also shown some possible health benefits. This review attempts to explore both the toxic and potential beneficial effects of glycoalkaloids on human health, as well as to evaluate the various laboratory methods currently employed for their quantification and determination. Additionally, it addresses the factors that contribute to increased glycoalkaloid levels in potatoes and highlights potential techniques to mitigate this toxicity throughout the production cycle, ensuring consumer safety.

糖生物碱是马铃薯自然合成的次生代谢物，当含量超过一定水平时就会中毒。鉴于马铃薯是全球消费最广泛的食物之一，开发能够控制这些化合物并优化积极影响其在块茎中浓度的条件的评估和分析方法至关重要。从马铃薯种植期间的农业做法到储存和商业分销条件，各种因素都可能影响糖生物碱，并可能导致毒性水平。因此，应用既能保持马铃薯质量又不影响其安全性的技术是至关重要的。虽然糖生物碱主要以其毒性和对人体健康的不利影响而闻名，但它们也显示出一些可能的健康益处。本综述试图探讨糖生物碱对人体健康的毒性和潜在的有益影响，并评估目前用于其定量和测定的各种实验室方法。此外，它还解决了导致马铃薯中糖生物碱含量增加的因素，并强调了在整个生产周期中减轻这种毒性的潜在技术，确保消费者安全。

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引用次数: 0

The synthetic cannabinoid CUMYL-4CN-BINACA induces hepatic injury in rats via oxidative stress, NF-κB activation, Nrf2 suppression, EDEM-1, ER stress-mediated apoptotic pathways 合成大麻素CUMYL-4CN-BINACA通过氧化应激、NF-κB激活、Nrf2抑制、EDEM-1、内质网应激介导的凋亡通路诱导大鼠肝损伤。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-16 DOI: 10.1016/j.fct.2025.115809

Tuba Dogan , Ozkan Aksakal , Omercan Alat , Mesut Bünyami Halici , Cihan Gur

Synthetic cannabinoids (SCs), particularly CUMYL-4CN-BINACA (C–4CN–B), are highly potent psychoactive substances linked to systemic toxicity, including liver injury. This study evaluated the dose-dependent hepatotoxic effects of C–4CN–B and the underlying molecular pathways in male Sprague Dawley rats. Thirty-two animals were divided into four groups (n = 8): a control group receiving vehicle (2 % ethanol, 2 % Tween 80, 96 % saline) and three treatment groups administered C–4CN–B intraperitoneally at 0.25, 0.5, or 1.0 mg/kg for 14 days. Liver function markers (ALT, AST, ALP) were analyzed biochemically. Oxidative stress indicators, including malondialdehyde (MDA) and reduced glutathione (GSH), were measured, while antioxidant enzymes (SOD, CAT, GPx) and apoptosis/inflammation-related proteins (Bax, Bcl-2, Caspase-3, NF-κB, TNF-α, IL-1β) were assessed via ELISA. Western blotting detected Keap-1, TLR-4, NF-κB, TNF-α, IL-6, IL-1β, HO-1, and Nrf2 expression. RT-qPCR profiled genes regulating oxidative and ER stress, including XBP-1, CHOP, GRP78, ATF4, EDEM1, Nrf2, and HO-1. C–4CN–B exposure caused dose-related increases in liver enzymes and MDA, alongside depletion of GSH and antioxidant enzymes. Pro-inflammatory cytokines and apoptotic markers were markedly upregulated. Molecular analyses showed NF-κB/TLR-4 activation, suppression of Nrf2/HO-1, and induction of ER stress genes. These findings indicate that C–4CN–B induces hepatotoxicity through oxidative stress, ER stress, and inflammatory-apoptotic signaling.

合成大麻素（SCs），特别是CUMYL-4CN-BINACA (C-4CN-B)，是与全身毒性（包括肝损伤）相关的高效精神活性物质。本研究评估了C-4CN-B对雄性大鼠的剂量依赖性肝毒性作用及其潜在的分子途径。将32只动物分为4组（n=8）：对照组给药（2%乙醇、2%吐温80、96%生理盐水），3个治疗组以0.25、0.5、1.0 mg/kg的剂量腹腔注射C-4CN-B，疗程14 d。生化分析肝功能指标（ALT、AST、ALP）。检测氧化应激指标丙二醛（MDA）和还原谷胱甘肽（GSH）， ELISA检测抗氧化酶（SOD、CAT、GPx）和凋亡/炎症相关蛋白（Bax、Bcl-2、Caspase-3、NF-κB、TNF-α、IL-1β）。Western blotting检测Keap-1、TLR-4、NF-κB、TNF-α、IL-6、IL-1β、HO-1、Nrf2的表达。RT-qPCR分析了调节氧化应激和内质网应激的基因，包括XBP-1、CHOP、GRP78、ATF4、EDEM1、Nrf2和HO-1。C-4CN-B暴露导致肝酶和MDA的剂量相关增加，同时GSH和抗氧化酶的消耗。促炎细胞因子和凋亡标志物明显上调。分子分析显示NF-κB/TLR-4活化，Nrf2/HO-1抑制，内质网应激基因诱导。这些发现表明，C-4CN-B通过氧化应激、内质网应激和炎症-凋亡信号传导诱导肝毒性。

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引用次数: 0

Bisphenol A exposure modulates ovarian cancer gene expression and oxidative stress markers: a case-control study 双酚A暴露调节卵巢癌基因表达和氧化应激标志物：一项病例对照研究。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-16 DOI: 10.1016/j.fct.2025.115810

Shimaa Ahmed Alsaeed , Ahmed M. Lymona , Adel Atef , Asmaa Mohammad Moawad , Heba Morsi , Marwa Alkaffas , Auhood Nassar , Heba Mohamed Aboubakr

In this case-control study conducted at Cairo's National Cancer Institute, the association between bisphenol A (BPA), an endocrine-disrupting chemical (EDC), and ovarian cancer was investigated. BPA levels in the urine, oxidative stress markers (reactive oxygen species (ROS) and superoxide dismutase (SOD) activity), and Keratin 4 (KRT4) gene expression were analyzed in 30 patients and 30 controls. Significant risk factors for BPA exposure included consuming microwave meals, consuming canned beverages, using polyvinyl chloride (PVC) food storage, eating fast food, handling thermal paper, exposure to dust, and recurrent hospitalizations. Compared with normal controls, ovarian cancer patients presented increased BPA levels, ROS, and KRT4 expression, along with reduced SOD activity (p < 0.001). A strong positive correlation was found between BPA and KRT4, indicating that KRT4 may be a potential biomarker. The cutoff values for urinary BPA and KRT4 achieved 100 % sensitivity and specificity in distinguishing patients from controls. These findings suggest that BPA plays a role in ovarian cancer pathogenesis, likely through oxidative stress and gene dysregulation. This study emphasizes the importance of minimizing BPA exposure (e.g., by reducing the use of canned or packaged foods) and calls for larger studies to further investigate the role of EDCs in hormone-dependent cancers.

在开罗国家癌症研究所进行的这项病例对照研究中，研究了双酚A (BPA)，一种内分泌干扰化学物质（EDC）和卵巢癌之间的关系。分析30例患者和30例对照组尿液中BPA水平、氧化应激标志物（活性氧（ROS）和超氧化物歧化酶（SOD）活性）和KRT4基因表达。BPA暴露的重要危险因素包括食用微波食品、饮用罐装饮料、使用PVC食品储存、吃快餐、处理热敏纸、接触灰尘和反复住院（均p < 0.001）。与正常对照相比，卵巢癌患者BPA水平、ROS和KRT4表达升高，SOD活性降低（p < 0.001）。BPA与KRT4呈显著正相关，提示KRT4是一种潜在的生物标志物。尿液BPA和KRT4的截止值在区分患者和对照组方面达到100%的敏感性和特异性。这些发现表明BPA可能通过氧化应激和基因失调在卵巢癌发病机制中发挥作用。这项研究强调了尽量减少BPA暴露的重要性（例如，通过减少使用罐装或包装食品），并呼吁进行更大规模的研究，进一步调查EDCs在激素依赖性癌症中的作用。

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引用次数: 0

Systematic review of cardiotoxicity associated with oral cadmium exposure 与口服镉暴露相关的心脏毒性的系统评价。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-16 DOI: 10.1016/j.fct.2025.115778

Heather R. Schaefer , Brenna M. Flannery , Abdul Ibrahim , Karlyn Middleton

The Food and Drug Administration (FDA) developed an oral cadmium (Cd) toxicological reference value (TRV) range of 0.21–0.36 μg/kg bw/day, based on similar points of departure (POD) for the bone and kidney (urinary Cd 0.5 μg/g creatinine) and 50 μg/g in the kidney cortex. Increasing evidence suggests that Cd exposure also affects the cardiovascular system. We conducted a systematic review through mid-September 2025 to determine if the current TRV is protective of cardiovascular events. We screened the title and abstract of 1354 references and conducted a full text review for 123 manuscripts. Fifty-three studies were excluded based on inclusion and exclusion criteria and 12 additional studies were included from the 2022 FDA systematic review for a total of 82 references. Animal studies indicated that Cd concentrations of 1–5 mg/L in drinking water resulted in elevated blood pressure in rats. For the epidemiological data, moderate evidence supports that atherosclerosis, myocardial infarction, cardiovascular mortality and blood pressure are presumed hazards to human health. Blood and urinary Cd levels for these effects are reported at ≥0.5 μg/g creatinine, respectively, the same POD used for the current TRV. Therefore, the current TRV of 0.21–0.36 μg/kg bw/day is protective of cardiovascular effects.

美国食品和药物管理局（FDA）制定了口服镉（Cd）毒理学参考值（TRV）范围为0.21-0.36 μg/kg体重/天，基于骨骼和肾脏的类似出发点（POD）（尿Cd 0.5 μg/g肌酐）和肾皮质50 μg/g)。越来越多的证据表明，接触镉也会影响心血管系统。我们在2025年9月中旬之前进行了一项系统评价，以确定当前的TRV是否对心血管事件有保护作用。我们筛选了1354篇参考文献的标题和摘要，并对123篇手稿进行了全文审阅。根据纳入和排除标准，53项研究被排除，另有12项研究从2022年FDA系统评价中被排除，共计82篇参考文献。动物研究表明，饮用水中1-5毫克/升的镉浓度会导致大鼠血压升高。就流行病学数据而言，适度证据支持动脉粥样硬化、心肌梗死、心血管死亡率和血压被认为是对人类健康的危害。据报道，这些影响的血Cd和尿Cd水平分别为≥0.5 μg/g肌酐，与当前TRV使用的POD相同。因此，目前的TRV为0.21 ~ 0.36 μg/kg bw/day，对心血管有保护作用。

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引用次数: 0

Dark chocolate, heavy metals, and neurodevelopment in children 黑巧克力、重金属和儿童神经发育。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-14 DOI: 10.1016/j.fct.2025.115799

Jagannadha Avasarala

Dark chocolate has been elevated to ‘superfood’ status, celebrated for its antioxidants and purported cardiovascular benefits. Yet, largely absent from pediatric discourse is a critical fact: many commercially available dark chocolates contain measurable levels of lead and cadmium—often higher than those found in milk or white chocolate. This contamination poses a heightened risk for Black and Hispanic children, who may be disproportionately affected compared to their non-Black, non-Hispanic peers. The American Heart Association (AHA), in its scientific statement, highlights that lead and cadmium exposures are disproportionately higher in communities of color and those with lower socioeconomic status, due to environmental injustice and increased exposure to sources such as contaminated water, industrial emissions, and tobacco smoke. In this short communication, an argument is laid out for improving explicit food safety labeling around dark chocolates given their neurotoxic effects in children, and specifically in children of color.

黑巧克力已被提升为“超级食物”，因其抗氧化剂和据称对心血管有益而闻名。然而，在儿科的讨论中，很大程度上忽略了一个关键的事实：许多市售的黑巧克力含有可测量的铅和镉含量——通常比牛奶巧克力或白巧克力中的含量要高。这种污染给黑人和西班牙裔儿童带来了更高的风险，与非黑人和非西班牙裔儿童相比，他们可能受到不成比例的影响。美国心脏协会（AHA）在其科学声明中强调，由于环境不公正以及受污染的水、工业排放和烟草烟雾等来源的暴露增加，有色人种社区和社会经济地位较低的社区的铅和镉暴露比例更高。在这篇简短的文章中，鉴于黑巧克力对儿童的神经毒性作用，特别是对有色人种儿童的神经毒性作用，作者提出了改善黑巧克力周围明确的食品安全标签的论点。

引用次数: 0

Definition of a chemical specific adjustment factor for human interindividual differences in kinetics for glutamates (E620-625) following oral intake in the absence and presence of food 在没有和存在食物的情况下，口服摄入谷氨酸（E620-625）后人类个体间动力学差异的化学特异性调节因子的定义。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-13 DOI: 10.1016/j.fct.2025.115794

Ivonne MCM Rietjens , Shintaro Yoshida , Atsushi Tsuruta , Takayuki Tanaka , Masanori Kohmura , Keigi Chin , Huichia Chao

Previously a chemical-specific adjustment factor (CSAF) for human interindividual variation in kinetics (HK_AF) was defined for glutamates (E620-625) based on steady-state human plasma and brain glutamate levels. The present study defines this HK_AF based on kinetic data upon oral intake of monosodium glutamate (MSG) by human individuals in the absence or presence of food. Data on maximum plasma glutamate levels (C_max) following oral intake of MSG were obtained from literature. The median HK_AF values obtained amounted for the 95th, 97.5th and 99th percentile to 1.86, 1.98 and 2.13 for MSG exposure without food and to 1.86, 2.00 and 2.15 with food when assuming normal distributions for the Monte Carlo simulations and excluding studies with SE > 20 % of the mean. Assuming lognormal distributions the values amounted to 1.97, 2.29 and 2.65 without food and to 1.92, 2.21 and 2.54 with food. Corresponding average HK_AF values weighted for the number of study subjects were comparable. These values are in line with the HK_AF values previously obtained under steady-state conditions for plasma and brain-related data, and together point at an HK_AF for interindividual differences in kinetics of 2 to be used when deriving an acceptable daily intake (ADI) for glutamates.

以前，基于稳态人血浆和脑谷氨酸水平，定义了谷氨酸（E620-625）的人类个体间动力学变异（HKAF）的化学特异性调节因子（CSAF）。本研究根据人体在没有或有食物的情况下口服谷氨酸钠（味精）的动力学数据来定义这种HKAF。口服味精后的最大血浆谷氨酸水平（Cmax）数据来源于文献。在蒙特卡罗模拟中假设正态分布并排除SE为平均值20%的研究时，获得的第95、975和99百分位数的HKAF值中位数分别为1.86、1.98和2.13，而在没有食物的情况下接触味精的中位数分别为1.86、2.00和2.15。假设对数正态分布，没有食物的值分别为1.97、2.29和2.65，有食物的值分别为1.92、2.21和2.54。按研究科目数目加权的相应HKAF平均分具有可比性。这些值与先前在稳态条件下获得的血浆和大脑相关数据的HKAF值一致，并共同指出了在获得谷氨酸可接受的每日摄入量（ADI）时使用的个体间动力学差异的HKAF值2。

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引用次数: 0

Mercury exposure and male fertility: Studying the impact of environmental bioaccumulation on semen quality 汞暴露与男性生育能力：环境生物积累对精液质量影响的研究。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-10 DOI: 10.1016/j.fct.2025.115798

Magda Carvalho Henriques , Joana Santiago , António Patrício , Maria Teresa Herdeiro , Susana Loureiro , Margarida Fardilha

In the last decades, growing evidence suggests a decline in male reproductive health, linked to a combination of lifestyle factors. Among environmental pollutants with potential reproductive toxicity, mercury (Hg) appears as a particularly concerning substance due to its ability to bioaccumulate in biological systems. However, controversial findings persist regarding the impact of Hg on fertility. This study assessed Hg exposure in men by analysing scalp hair samples and studying associations with semen parameters. Eligible men were recruited and data on sociodemographic, socioeconomic, lifestyle and reproductive health were obtained through a comprehensive questionnaire. Semen and scalp hair samples were collected for experimental analysis. Our findings revealed significant Hg bioaccumulation in all scalp hair samples, with 41 % exceeding 1000 ng/g, and 11 % surpassing 2000 ng/g. A significant positive correlation was observed between total Hg (THg) levels in scalp hair samples and sperm principal piece defects, as well as higher teratozoospermia index. Among the factors influencing Hg bioaccumulation, fish consumption may be an important contributor to elevated Hg levels. These results provided additional information for conducting Hg risk assessment for male reproductive health. Further and continuous monitoring of Hg exposure should be required to prevent possible adverse effects on male reproduction.

在过去的几十年里，越来越多的证据表明，男性生殖健康状况有所下降，这与多种生活方式因素有关。在具有潜在生殖毒性的环境污染物中，汞（Hg）由于其在生物系统中的生物积累能力而成为一种特别值得关注的物质。然而，关于汞对生育能力的影响，有争议的发现仍然存在。本研究通过分析头皮头发样本和研究与精液参数的关系来评估男性汞暴露。招募了符合条件的男性，并通过一份全面的问卷收集了社会人口、社会经济、饮食、生活方式和生殖健康方面的数据。采集精液和头皮毛发样本进行实验分析。我们的研究结果显示，所有头皮头发样本中汞的生物积累显著，41%超过1000 ng/g， 11%超过2000 ng/g。头皮毛发样品中总汞（THg）水平与精子主片缺陷和畸形精子症指数呈显著正相关。在影响汞生物积累的因素中，鱼类消费可能是汞水平升高的重要因素。这些结果为开展汞对男性生殖健康的风险评估提供了额外信息。应进一步和持续监测汞暴露，以防止可能对男性生殖产生不利影响。

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引用次数: 0

Monitoring of microplastics, ions and heavy metals in disposable paper cups from Turkiye marketplaces 土耳其市场一次性纸杯中微塑料、离子和重金属的监测。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-10-10 DOI: 10.1016/j.fct.2025.115797

Ayca Aktas Sukuroglu , Kumsal Kocadal , Asena Ayca Ozdemir , Dilek Battal

Microplastics' ubiquitous exposure and their function of carrying over organic pollutants have sparked concerns about the environment and human health. This study aimed to monitor possible microplastic contents in paper cups from Türkiye marketplaces. To achieve this, 10 different paper cups from different manufacturers were obtained. The microplastic contents were analysed qualitatively; the heavy metal and ion contents were assessed quantitatively, and the results were supported by visual instrumental imaging techniques and analysis methods (SEM, confocal microscopy). According to the results obtained, it was shown that the inner film of disposable cups contains High-Density Polyethylene (HDPE), and this changes in structure when in contact with hot beverages. Moreover, it was observed that microplastics, heavy metals such as 394.54 ppb Zinc, 58.05 ppb Aluminium as well as ions such as 1.07 ppm Ammonium, 17.49 ppm Chloride migrated when the inner layer of disposable paper cups came into contact with a hot beverage for 15 min. Although paper-based materials are now considered “safer alternatives”, they may actually be a cause for concern due to the transfer of microplastics and other contaminants present in the structure of paper-containing products into the consumed product.

微塑料无处不在的暴露及其携带有机污染物的功能引发了人们对环境和人类健康的担忧。这项研究旨在监测来自 rkiye市场的纸杯中可能存在的微塑料含量。为了实现这一目标，我们从不同的制造商那里获得了10个不同的纸杯。定性分析了微塑料含量；对重金属和离子含量进行了定量评估，结果得到了视觉仪器成像技术和分析方法（扫描电镜、共聚焦显微镜）的支持。结果表明，一次性杯子的内膜含有高密度聚乙烯（HDPE），当与热饮接触时，其结构会发生变化。此外，当一次性纸杯内层与热饮接触15分钟时，观察到微塑料，重金属（如394.54 ppb锌，58.05 ppb铝）以及离子（如1.07 ppm铵，17.49 ppm氯）迁移。虽然纸基材料现在被认为是“更安全的替代品”，但它们实际上可能是一个令人担忧的问题，因为含有纸的产品结构中存在的微塑料和其他污染物会转移到消费产品中。

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