Food and Chemical Toxicology最新文献_第10页

Aspartame promotes ovarian cancer progression: A multi-omics study integrating mendelian randomization, network toxicology, and in vitro validation 阿斯巴甜促进卵巢癌进展：一项整合孟德尔随机化、网络毒理学和体外验证的多组学研究。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-12 DOI: 10.1016/j.fct.2025.115901

Qingquan Gong , Dingyu Liang , Yongjin Luo , Chao Yang , Yihua Yang , Shujie Zhang

The causal relationship between the artificial sweetener aspartame and ovarian cancer (OC), a highly lethal malignancy, remains unclear. This study, therefore, employed a multi-omics approach to investigate this causal link and its potential mechanisms. First, a Mendelian Randomization (MR) analysis indicated that genetically predicted aspartame intake is associated with an increased risk of OC (OR = 2.10, 95 % CI: 1.06–4.18). Next, by integrating network toxicology with machine learning algorithms (LASSO, SVM, and Random Forest), we identified AURKA, CCND1, and RAD51 as potential core target genes. Further validation using multi-omics data from bulk and single-cell RNA sequencing confirmed that these three genes are upregulated in OC tissues. A subsequent MR analysis also provided causal evidence that high expression of CCND1 increases the risk of OC. Furthermore, molecular docking simulations showed that aspartame could form stable bonds with all three target proteins. Finally, in vitro experiments demonstrated that aspartame significantly promoted the malignant phenotypes of OC cells and regulated the expression of these core genes. In conclusion, this study suggests that aspartame may promote ovarian cancer development, potentially by upregulating the expression of key genes such as AURKA, CCND1, and RAD51. These findings provide new evidence for evaluating the safety of aspartame.

人工甜味剂阿斯巴甜与卵巢癌（一种高度致命的恶性肿瘤）之间的因果关系尚不清楚。因此，本研究采用多组学方法来研究这种因果关系及其潜在机制。首先，孟德尔随机化（MR）分析表明，基因预测的阿斯巴甜摄入量与OC风险增加相关（OR = 2.10, 95% CI: 1.06-4.18）。接下来，通过将网络毒理学与机器学习算法（LASSO、SVM和Random Forest）相结合，我们确定了AURKA、CCND1和RAD51作为潜在的核心靶基因。通过大量和单细胞RNA测序的多组学数据进一步验证，证实这三个基因在OC组织中上调。随后的MR分析也提供了因果证据，表明CCND1的高表达增加了OC的风险。此外，分子对接模拟表明，阿斯巴甜可以与所有三种靶蛋白形成稳定的键。最后，体外实验表明，阿斯巴甜显著促进OC细胞的恶性表型，并调节这些核心基因的表达。综上所述，本研究提示阿斯巴甜可能通过上调AURKA、CCND1和RAD51等关键基因的表达来促进卵巢癌的发展。这些发现为评价阿斯巴甜的安全性提供了新的依据。

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引用次数: 0

Health risks associated with the consumption of shrimp and squid contaminated with heavy metals in Poland 波兰与食用受重金属污染的虾和鱿鱼有关的健康风险。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-12 DOI: 10.1016/j.fct.2025.115897

Jolanta Charchuła , Grzegorz Dziubanek , Danuta Rogala , Anna Niesler

Seafood may accumulate heavy metals (HMs) from environmental sources, posing potential health risks through dietary intake. This study aimed to assess the health risk associated with dietary intake of Hg, Cd, As and Zn from selected seafood available in Poland. In this study, a total 51 samples of shrimp and squid were analysed. The metals content was determined using such analytical methods as ET-AAS with a graphite furnace in the case of Cd, ICP-OES in the case of As and Zn, and CV-AFS in the case of Hg. The mean content of Cd and Zn were found to be 0.25 and 16.94 mg/kg f. w., respectively. In the case of Hg and As, these metals were detected at concentrations of 0.023 and 11.71 mg/kg f. w. The number of samples exhibiting results higher than the LOQ for Cd, As, Zn and Hg were found to be 24, 1, 50 and 1, respectively. The heavy metals content generally did not exceed the maximum permissible concentrations. Elevated content of Cd were detected in a single shrimp sample. The HI exceeded 1 among adults and children, with arsenic in shrimp identified as the predominant contributor. The ingestion of As from highest contaminated shrimp sample has been associated an elevated cancer risk among adult (2.33 × 10–3) and children (5.44 × 10–3). The findings of this study indicate that, in order to ensure the health safety of consumers, it is necessary to undertake more effective monitoring of the HMs content in seafood available in the Polish market.

海产品可能从环境来源积累重金属，通过饮食摄入构成潜在的健康风险。本研究旨在评估从波兰选定的海产品中摄入汞、镉、砷和锌的相关健康风险。本研究共分析了51份虾和鱿鱼样本。采用石墨炉ET-AAS法测定Cd， ICP-OES法测定as和Zn， CV-AFS法测定Hg，其中Cd和Zn的平均含量分别为0.25和16.94 mg/kg f.w。Hg和As的检测浓度分别为0.023和11.71 mg/kg f.w。Cd、As、Zn和Hg的检测结果高于定量限的样品数量分别为24、1、50和1。重金属含量一般不超过最大允许浓度。在单个虾样品中检测到镉含量升高。成人和儿童的HI均超过1，其中虾类中的砷是主要贡献者。从污染最严重的虾样本中摄入砷与成人（2.33×10-3）和儿童（5.44×10-3）的癌症风险升高有关。本研究结果表明，为了确保消费者的健康安全，有必要对波兰市场上出售的海产品中的HMs含量进行更有效的监测。

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引用次数: 0

FEMA GRAS assessment of natural flavor complexes: Pepper, ginger, coniferous-derived and related flavoring ingredients 天然风味复合物的FEMA GRAS评估：胡椒、姜、针叶树衍生及相关调味成分。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-11 DOI: 10.1016/j.fct.2025.115849

Stephen S. Hecht , Samuel M. Cohen , Gerhard Eisenbrand , Shoji Fukushima , Nigel J. Gooderham , F. Peter Guengerich , Ivonne M.C.M. Rietjens , Thomas J. Rosol , Jeanne M. Davidsen , Christie L. Harman , Sean V. Taylor

As part of the Expert Panel of the Flavor and Extract Manufacturers Association's (FEMA) program to evaluate the safety of flavor ingredients, this publication, thirteenth in the series, details the re-evaluation of natural flavor complexes (NFCs) whose constituent profiles are characterized by mono- and sesquiterpene hydrocarbons. The Panel's constituent-based safety evaluation procedure parses the identified constituents of each NFC into well-defined congeneric groups. For each congeneric group, an evaluation based on the estimated intake is conducted using the conservative Threshold of Toxicological Concern (TTC) approach and a review of available data on absorption, metabolism and toxicity, including genotoxicity, for identified constituents and the NFCs, is conducted. The scope of the safety evaluation of the NFCs contained herein does not include added use in dietary supplements or any products other than food. Thirty-five NFCs, derived from the Angelica, Abies, Cananga, Croton, Apium, Canarium, Erigeron, Ferula, Zingiber, Humulus, Juniperus, Cistus, Commiphora, Boswellia, Piper, Pinus and Schinus genera were determined/affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavoring ingredients based on an evaluation of each NFC and the constituents and congeneric groups therein.

作为香料和提取物制造商协会（FEMA）评估香料成分安全性计划的专家小组的一部分，本出版物是该系列的第十三篇，详细介绍了以单萜和倍半萜烃为特征的天然香料复合物（nfc）的重新评估。专家小组基于成分的安全性评估程序将每个NFC的已识别成分解析为定义良好的同类组。对于每一个同类组，采用保守的毒理学关注阈值（TTC）方法，根据估计摄入量进行评估，并对已确定成分和nfc的吸收、代谢和毒性（包括遗传毒性）的现有数据进行审查。本文所包含的nfc安全性评估的范围不包括在膳食补充剂或食品以外的任何产品中的添加使用。基于对每种NFC及其成分及其同源类群的评估，35种NFC在其预期使用条件下被确定/确认为一般公认安全（GRAS），这些NFC来自当归、冷杉、甘南、巴豆、Apium、Canarium、Erigeron、阿弗拉、生姜、葎草、杜松、山茱萸、Commiphora、Boswellia、Piper、Pinus和Schinus属。

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引用次数: 0

Multiple approaches revealed ImKC cells as a RAW 264.7 derivative rather than a Kupffer cell line 多种方法显示ImKC细胞是RAW 264.7的衍生物，而不是Kupffer细胞系。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-11 DOI: 10.1016/j.fct.2025.115900

Ting Shao, Yue-Lei Chen

Immortalized cell lines function as invaluable tools in life science and preclinical studies. Poor laboratory practices can lead to cell line misidentification, cross-contamination, and mislabelling, resulting in invalid, misleading, and unrepeatable results. The issue of nonhuman-derived cell misidentification was once discovered timely, but it received less attention than the misidentification of human cells. Consequently, problematic murine cell lines still appear frequently in the literature. For instance, ImKC cells have been applied as a mouse Kupffer cell line in the last decade. In this report, we revealed that the ImKC cell line was a RAW 264.7 derivative through STR analysis, and further determined that it was not an SV40-transformed cell line by PCR and western blotting assays. Moreover, we outlined the relevant publications using the ImKC cell line. This study aims to prevent further researchers from employing the problematic cell line in their studies.

永生化细胞系是生命科学和临床前研究的宝贵工具。不良的实验室操作可能导致细胞系错误鉴定、交叉污染和错误标记，从而导致无效、误导和不可重复的结果。非人源性细胞的错误鉴定问题虽然被及时发现，但受到的关注却不及人源性细胞的错误鉴定。因此，有问题的小鼠细胞系仍然经常出现在文献中。例如，在过去十年中，ImKC细胞已被应用于小鼠Kupffer细胞系。在本报告中，我们通过STR分析发现ImKC细胞系为RAW 264.7衍生物，并通过PCR和western blotting进一步确定其不是sv40转化细胞系。此外，我们概述了使用ImKC细胞系的相关出版物。这项研究旨在防止进一步的研究人员在他们的研究中使用有问题的细胞系。

引用次数: 0

Interaction of deoxynivalenol and copper: Cellular and molecular insights in mouse liver cells 脱氧雪腐烯醇和铜的相互作用：小鼠肝细胞的细胞和分子观察。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-09 DOI: 10.1016/j.fct.2025.115892

Hui Jiang , Junhua Yang , Xichun Wang , Lihui Zhu

Deoxynivalenol (DON) and copper (Cu) are crucial food-related contaminants associated with health risks in both animals and humans. This study investigated the individual and combined effects of DON and Cu on a mouse hepatocyte line NCTC1469 cells. The results demonstrated that both DON and Cu induced ultrastructural damage, promoted mitochondrial vacuolization, increased pro-inflammatory cytokine levels, such as interleukin-1β (IL-1β) and tumor necrosis factor-alpha, reduced cell viability, and suppressed antioxidant enzyme activity, including glutathione and superoxide dismutase. Notably, DON + Cu enhanced cell viability compared to DON alone. In addition, co-treatment significantly reduced IL-1β levels relative to DON alone at 0.625, 1.25, and 2.5 μM. Transcriptome sequencing revealed that both DON alone and DON-Cu co-exposure triggered numerous differentially expressed genes, which were notably enriched in autophagy related pathways, such as ribosome biogenesis in eukaryotes, lysosome, spliceosome, and cell cycle. Meanwhile, the relative protein ratio of LC3-II/LC3-I was elevated at 0.65 μM DON, while the p62 expression was decreased in a dose-dependent manner compared to the control. In summary, DON exerts toxic effects on mouse hepatocytes, while Cu can mitigate DON-induced cellular damage at low concentrations, likely through involvement in Beclin-1/p62 related autophagic regulation.

脱氧雪腐镰刀菌醇（DON）和铜（Cu）是与食物有关的重要污染物，与动物和人类的健康风险有关。本研究考察了DON和Cu对小鼠肝细胞系NCTC1469细胞的单独和联合作用。结果表明，DON和Cu均可诱导超微结构损伤，促进线粒体空泡化，增加促炎细胞因子如白细胞介素-1β (IL-1β)和肿瘤坏死因子α水平，降低细胞活力，抑制抗氧化酶如谷胱甘肽和超氧化物歧化酶活性。值得注意的是，与单独使用DON相比，DON + Cu可提高细胞活力。此外，在0.625 μM、1.25 μM和2.5 μM下，与DON单独处理相比，共处理显著降低了IL-1β水平。转录组测序显示，DON单独和DON- cu共暴露均触发了大量差异表达基因，这些基因在真核生物的核糖体生物发生、溶酶体、剪接体和细胞周期等自噬相关途径中显著富集。与此同时，LC3-II/LC3-I的相对蛋白比在0.65 μM DON时升高，而p62的表达量与对照相比呈剂量依赖性降低。综上所述，DON对小鼠肝细胞具有毒性作用，而Cu可以在低浓度下减轻DON诱导的细胞损伤，可能通过参与Beclin-1/p62相关的自噬调节。

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引用次数: 0

The toxic effects of doxorubicin and trastuzumab on cardiac metabolic reprogramming are associated with impaired mitochondrial dynamics balance 阿霉素和曲妥珠单抗对心脏代谢重编程的毒性作用与线粒体动力学平衡受损有关。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-09 DOI: 10.1016/j.fct.2025.115895

Chanisa Thonusin , Chayodom Maneechote , Siriporn C. Chattipakorn , Nipon Chattipakorn

The toxicity of doxorubicin and trastuzumab can lead to heart failure. Its pathophysiology is correlated with cardiac metabolic reprogramming. Therefore, we investigated the effects of doxorubicin and trastuzumab on cardiac metabolic reprogramming. Since mitochondrial dynamics imbalance is associated with cardiotoxicity, we evaluated the effects of restoring balance of mitochondrial dynamics on reducing cardiotoxicity. Male Wistar rats received either vehicle, 6 doses of 3 mg/kg of doxorubicin, or 4 mg/kg/day of trastuzumab. Doxorubicin-treated rats and trastuzumab-treated rats were also co-treated with either vehicle, 1.2 mg/kg/day of MDiVi1 (mitochondrial fission inhibitor), or 2 mg/kg/day of M1 (mitochondrial fusion promoter). The treatment duration was 30 and 7 days for doxorubicin and trastuzumab studies, respectively. Thereafter, cardiac function was determined. The rats were then euthanized to collect cardiac ventricular tissues for targeted metabolomics via liquid chromatography coupled with mass spectrometry. We found that doxorubicin and trastuzumab caused increased glycolysis, increased ketone body metabolism, decreased fatty acid utilization, decreased succinate oxidation, and decreased ATP production. These changes were more severe in doxorubicin-treated rats. Restoring mitochondrial dynamics balance by MDiVi1 or M1 improved cardiac metabolic reprogramming. These novel findings highlighted the toxic effects of doxorubicin and trastuzumab on cardiac metabolic reprogramming and their association with mitochondrial dynamics. Also, metabolomics might be used as a tool for treatment monitoring in doxorubicin- and trastuzumab-induced cardiotoxicity.

阿霉素和曲妥珠单抗的毒性可导致心力衰竭。其病理生理与心脏代谢重编程有关。因此，我们研究了阿霉素和曲妥珠单抗对心脏代谢重编程的影响。由于线粒体动力学失衡与心脏毒性有关，我们评估了恢复线粒体动力学平衡对减少心脏毒性的影响。雄性Wistar大鼠分别接受6剂3mg /kg阿霉素或4mg /kg/天曲妥珠单抗。阿霉素处理的大鼠和曲妥珠单抗处理的大鼠也分别用1.2 mg/kg/天的MDiVi1（线粒体裂变抑制剂）或2 mg/kg/天的M1（线粒体融合启动子）进行处理。阿霉素和曲妥珠单抗研究的治疗时间分别为30天和7天。随后测定心功能。然后对大鼠实施安乐死，通过液相色谱联用质谱法收集心脏心室组织进行靶向代谢组学研究。我们发现阿霉素和曲妥珠单抗导致糖酵解增加，酮体代谢增加，脂肪酸利用减少，琥珀酸氧化减少，ATP产生减少。这些变化在阿霉素治疗的大鼠中更为严重。通过MDiVi1或M1恢复线粒体动力学平衡可改善心脏代谢重编程。这些新发现强调了阿霉素和曲妥珠单抗对心脏代谢重编程的毒性作用及其与线粒体动力学的关联。此外，代谢组学可能用作阿霉素和曲妥珠单抗诱导的心脏毒性治疗监测的工具。

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引用次数: 0

Differential effects of gestational arsenic exposure on the liver and kidney of rat offspring across postnatal development 妊娠期砷暴露对大鼠后代出生后肝脏和肾脏发育的不同影响。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-09 DOI: 10.1016/j.fct.2025.115894

Daniel Silva Sena Bastos , Pedro Henrique de Carvalho Albuquerque de Souza , Mariana Machado-Neves , Luiz Otávio Guimarães-Ervilha , Leandro Licursi de Oliveira , Renê Chagas da Silva , Marcos Antônio José dos Santos , Wallace Martins de Araújo , Ana Cláudia Ferreira Souza

Arsenic is a widespread environmental contaminant capable of crossing the placental barrier, posing risks to fetal development. This study evaluated the long-term effects of prenatal arsenic exposure on the liver and kidney of male Wistar rat offspring at prepubertal (PND15), peripubertal (PND28, 44) and adult (PND70) stages. Pregnant rats received 10 mg/L sodium arsenite in drinking water from gestational day 1 until parturition. Results revealed that prenatal arsenic exposure led to growth restriction until peripuberty and persistent arsenic accumulation in both organs. In the liver, significant alterations included increased serum AST and ALP, and disrupted SOD and CAT activity at different ages. These alterations were accompanied by elevated protein carbonylation and histopathological changes such as inflammation, vascular congestion and hydropic degeneration, especially at peripubertal and adult stages. In contrast, the kidney exhibited enhanced SOD and GST activity without corresponding increases in oxidative damage markers or histopathological lesions, despite some micromineral imbalances. Overall, the liver emerged as the primary target of prenatal arsenic-induced toxicity, whereas the kidney showed increased antioxidant enzyme activity in the absence of overt damage. These findings highlight the importance of intrauterine exposure timing in determining postnatal organ health and the liver's vulnerability to developmental arsenic toxicity.

砷是一种广泛存在的环境污染物，能够穿过胎盘屏障，对胎儿发育构成风险。本研究评估了产前砷暴露对青春期前（PND15）、青春期周围（PND28、44）和成年期（PND70）雄性Wistar大鼠后代肝脏和肾脏的长期影响。妊娠大鼠从妊娠第1天至分娩时，在饮用水中添加10 mg/L亚砷酸钠。结果显示，产前砷暴露导致生长限制，直到青春期周围和持续的砷积累在两个器官。在肝脏中，显著的变化包括不同年龄的血清AST和ALP升高，SOD和CAT活性破坏。这些改变伴随着蛋白羰基化升高和组织病理学改变，如炎症、血管充血和水肿变性，特别是在青春期和成年期。相比之下，肾脏表现出SOD和GST活性增强，但氧化损伤标志物或组织病理学病变没有相应增加，尽管存在一些微量矿物质失衡。总的来说，肝脏是产前砷中毒的主要目标，而肾脏在没有明显损伤的情况下显示出抗氧化酶活性的增加。这些发现强调了宫内暴露时间在决定出生后器官健康和肝脏对发育性砷毒性的易感性方面的重要性。

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引用次数: 0

Differential effects on acetaminophen-induced nephrotoxicity and liver injury following modulation of glutathione resynthesis 调节谷胱甘肽再合成对乙酰氨基酚引起的肾毒性和肝损伤的不同影响。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-09 DOI: 10.1016/j.fct.2025.115896

Yasaman Etemadi , Jephte Y. Akakpo , Timothy A. Fields , Anup Ramachandran , Hartmut Jaeschke

Acetaminophen (APAP) overdose is a leading cause of acute liver failure (ALF), with acute kidney injury (AKI) increasing morbidity and mortality. N-acetylcysteine (NAC) prevents APAP-induced liver damage, but not AKI, highlighting the need to address differential inter-organ responses to APAP toxicity. We investigated the relationship between hepatic glutathione (GSH) depletion, liver injury, and subsequent kidney damage following APAP overdose. Male C57BL/6J mice received either moderate (300 mg/kg) or severe (600 mg/kg) overdoses of APAP, with or without buthionine sulfoximine (BSO, 50 mg/kg) to deplete GSH, or NAC (500 mg/kg) to replenish GSH. A moderate APAP overdose elevated liver injury markers (alanine aminotransferase, ALT) without significantly affecting blood urea nitrogen (BUN) levels, though kidney injury molecule-1 (KIM-1) expression increased. A severe overdose significantly increased ALT activities, and BUN and creatine levels, together with marked upregulation of renal KIM-1 and histological evidence of cortical damage. BSO exacerbated APAP-induced kidney but not liver injury, where GSH remained depleted at 24 h. In contrast, NAC protected against APAP hepatotoxicity but not AKI. Thus, these findings demonstrate critical organ-specific responses to APAP toxicity and underscore the need for targeted therapeutic strategies specifically addressing APAP-induced kidney injury.

对乙酰氨基酚（APAP）过量是急性肝衰竭（ALF）的主要原因，急性肾损伤（AKI）增加了发病率和死亡率。n -乙酰半胱氨酸（NAC）可以预防APAP诱导的肝损伤，但不能预防AKI，这强调了解决APAP毒性的器官间差异反应的必要性。我们研究了肝谷胱甘肽（GSH）耗竭、肝损伤和APAP过量后的肾损害之间的关系。雄性C57BL/6J小鼠分别给予中度（300 mg/kg）或重度（600 mg/kg）过量APAP，加或不加丁氨酸亚砜（BSO, 50 mg/kg）以消耗谷胱甘肽，或NAC （500 mg/kg）以补充谷胱甘肽。适度过量APAP可升高肝损伤标志物（谷丙转氨酶，ALT），但不显著影响血尿素氮（BUN）水平，但肾损伤分子-1 （KIM-1）表达增加。严重的过量显著增加ALT活性、BUN和肌酸水平，同时肾脏KIM-1显著上调，组织学证据表明皮质损伤。BSO加重了apap诱导的肾损伤，但不加重肝损伤，GSH在24小时仍处于耗尽状态。NAC对APAP肝毒性有保护作用，对AKI无保护作用。因此，这些发现证明了APAP毒性的关键器官特异性反应，并强调了针对APAP诱导的肾损伤的靶向治疗策略的必要性。

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引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8 更新RIFM香料成分安全评估，3-甲基-2-丁烯乙酸酯，CAS注册号1191-16-8。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-08 DOI: 10.1016/j.fct.2025.115887

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Respond to the letter submitted to the editor entitled “Beyond monitoring: Integrating risk, benefit, and biomonitoring in Greek dietary exposure to dioxins and PCBs” by Parthe Aphale et al. regarding our publication by Costopoulou et al. titled “Dioxin and PCB monitoring in Greek food products during the period 2002–2022 and preliminary assessment of general population exposure through the diet” (Food Chem Toxicol. 2025;206:115717) 回复Parthe Aphale等人就Costopoulou等人发表的题为“2002-2022年期间希腊食品中二恶英和多氯联苯的监测以及通过饮食对一般人群暴露的初步评估”（food Chem Toxicol. 2025;206:115717）的文章提交给编辑的题为“超越监测：整合希腊饮食暴露二恶英和多氯联苯的风险、收益和生物监测”的信。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2025-12-07 DOI: 10.1016/j.fct.2025.115845

Danae Costopoulou, Irene Vassiliadou, Kleopatra Kedikoglou, Constantina Grigoriou, Leondios Leondiadis

引用次数: 0