Food and Chemical Toxicology最新文献

英文中文

G protein-coupled estrogen receptor activation attenuates cisplatin-induced CKD in C57BL/6 mice: An insight into sex-related differences G 蛋白偶联雌激素受体激活可减轻 C57BL/6 小鼠顺铂诱导的 CKD：洞察性别差异

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-02 DOI: 10.1016/j.fct.2024.115079

Hala A. Ahmed , Ahmed A. Shaaban , Tarek M. Ibrahim , Mirhan N. Makled

Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) post-cisplatin therapy. This study aims at investigating the potential effect of G1 compound, a GPER agonist, on attenuating cisplatin-induced CKD. To induce CKD in male, intact female, and ovariectomized (OVX) mice, CKD was induced by injecting two cycles of 2.5 mg/kg cisplatin with a 16-day recovery period between cycles). G1 (50 or 100 μg/kg was administered daily for 6 weeks. Severity of renal damage was more pronounced in males than females. Interestingly, OVX resulted in renal damage that is non-significant compared to males and significantly higher than females. G1 improved renal function and blood flow as evidenced by reduction of serum creatinine and elevation of creatinine clearance, NO production, and reduction of ET1. This renoprotective effect could be attributed to its immunomodulatory effect regulated by TGF-β that shifted the balance to favor anti-inflammatory cytokine production (increased IL-10) rather than pro-inflammatory cytokines (decreased Th17 expression). Reduction of TGF-β activation also inhibited epithelial-to-mesenchymal transition that eventually ameliorated CKD development. Antioxidant potential of G1 has been demonstrated by upregulation of Nrf2 and subsequent antioxidant enzymes. These data suggest that G1 could be a promising therapeutic tool to attenuate CP-induced CKD.

顺铂治疗后慢性肾脏病（CKD）的发病率和进展与性别差异有关。本研究旨在探讨G1化合物（一种GPER激动剂）对减轻顺铂诱导的慢性肾脏病的潜在作用。为了诱导雄性小鼠、完整雌性小鼠和卵巢切除（OVX）小鼠的慢性肾功能衰竭，通过注射两个周期的 2.5 毫克/千克顺铂（两个周期之间有 16 天的恢复期）来诱导慢性肾功能衰竭。每天注射 G1（50 或 100 μg/kg），持续 6 周。与雌性动物相比，雄性动物的肾损伤更为严重。有趣的是，卵巢切除术导致的肾损伤与雄性相比不明显，但明显高于雌性。血清肌酐的降低、肌酐清除率的升高、NO的产生以及ET1的减少都证明了G1能改善肾功能和血流量。这种肾脏保护作用可归因于其受 TGF-β 调节的免疫调节作用，该作用使平衡转向有利于抗炎细胞因子的产生（IL-10 增加），而不是有利于促炎细胞因子的产生（Th17 表达减少）。减少 TGF-β 的激活还能抑制上皮细胞向间质转化，最终改善慢性肾脏病的发展。通过上调 Nrf2 和随后的抗氧化酶，证明了 G1 的抗氧化潜力。这些数据表明，G1 是一种很有前景的治疗工具，可减轻 CP 引起的 CKD。

{"title":"G protein-coupled estrogen receptor activation attenuates cisplatin-induced CKD in C57BL/6 mice: An insight into sex-related differences","authors":"Hala A. Ahmed , Ahmed A. Shaaban , Tarek M. Ibrahim , Mirhan N. Makled","doi":"10.1016/j.fct.2024.115079","DOIUrl":"10.1016/j.fct.2024.115079","url":null,"abstract":"<div><div>Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) post-cisplatin therapy. This study aims at investigating the potential effect of G1 compound, a GPER agonist, on attenuating cisplatin-induced CKD. To induce CKD in male, intact female, and ovariectomized (OVX) mice, CKD was induced by injecting two cycles of 2.5 mg/kg cisplatin with a 16-day recovery period between cycles). G1 (50 or 100 μg/kg was administered daily for 6 weeks. Severity of renal damage was more pronounced in males than females. Interestingly, OVX resulted in renal damage that is non-significant compared to males and significantly higher than females. G1 improved renal function and blood flow as evidenced by reduction of serum creatinine and elevation of creatinine clearance, NO production, and reduction of ET1. This renoprotective effect could be attributed to its immunomodulatory effect regulated by TGF-β that shifted the balance to favor anti-inflammatory cytokine production (increased IL-10) rather than pro-inflammatory cytokines (decreased Th17 expression). Reduction of TGF-β activation also inhibited epithelial-to-mesenchymal transition that eventually ameliorated CKD development. Antioxidant potential of G1 has been demonstrated by upregulation of Nrf2 and subsequent antioxidant enzymes. These data suggest that G1 could be a promising therapeutic tool to attenuate CP-induced CKD.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115079"},"PeriodicalIF":3.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac oxylipin perturbances in response to 2-monochloropropane-1,3-diol exposure are ameliorated by dietary adequacy of the essential n-3 fatty acid, α-linolenic acid 膳食中摄入充足的必需 n-3 脂肪酸（α-亚麻酸）可部分改善心脏氧脂对 2-一氯丙烷-1,3-二醇暴露的扰动。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-02 DOI: 10.1016/j.fct.2024.115080

Lucien GJ. Cayer , Tobias Karakach , Jennifer Roberts , Stephen PJ. Brooks , Jayadev Raju , Harold M. Aukema

2-Monochloropropane-1,3-diol (2-MCPD) is a food contaminant with demonstrated cardiotoxicity in rats. This adverse effect was previously associated with lower anti-inflammatory docosahexaenoic acid (DHA)-derived cardiac oxylipins in F344 rats. This previous study utilized corn oil as the dietary lipid; we therefore investigated whether deficient (0.07 g/100 g diet) or adequate (0.5 g/100 g diet) dietary α-linolenic acid (ALA), the essential n-3 polyunsaturated fatty acid (PUFA), alters the oxylipin response in heart, liver, kidney, and serum of Sprague-Dawley rats exposed to 50 mg 2-MCPD/kg BW/day. ALA increased n-3 oxylipins in all tissues, reflecting greater n-3 PUFA substrate availability. In the heart, 2-MCPD increased cyclooxygenase-derived arachidonic acid oxylipins, conducive to inflammation. Adequate dietary ALA revealed 2-MCPD-induced reductions of anti-inflammatory cardiac DHA-derived oxylipins; these were not apparent in the ALA-deficient diet as these n-3 PUFA oxylipins were already reduced. Conversely, 2-MCPD increased cardiac 13-hydroxy-octadecatrienoic acid-γ (13-HOTrE-γ) levels with deficient, but not adequate, ALA diets. Multi-tissue analysis identified 13-HOTrE-γ as a marker of 2-MCPD exposure. Our study contributes to the weight-of-evidence of 2-MCPD toxicity, confirms the functional and indicative roles of oxylipins in the heart, and demonstrates that live bioassays determining chemical health hazards should use adequate n-3 PUFA diets.

2- 氯丙二醇（2-MCPD）是一种食品污染物，对大鼠具有心脏毒性。这种不良影响与 F344 大鼠体内抗炎性较低的二十二碳六烯酸（DHA）衍生的心脏氧脂有关。因此，我们研究了α-亚麻酸（ALA）（一种必需的 n-3 多不饱和脂肪酸（PUFA））不足（0.07 克/100 克膳食）或充足（0.5 克/100 克膳食）是否会改变暴露于 50 毫克 2-MCPD/kg 体重/天的 Sprague-Dawley 大鼠心脏、肝脏、肾脏和血清中的氧脂反应。ALA 增加了所有组织中的 n-3 氧脂素，反映了更多的 n-3 PUFA 底物可用性。在心脏中，2-氯丙二醇增加了环氧合酶衍生的花生四烯酸氧脂，从而导致炎症。充足的 ALA 膳食显示，2-氯丙二醇诱导的抗炎性心脏 DHA 衍生氧脂减少；在 ALA 缺乏的膳食中，这种情况并不明显，因为这些 n-3 PUFA 氧脂已经减少。相反，2-氯丙二醇会增加心脏 13-羟基-十八碳三烯酸-γ（13-HOTrE-γ）的水平，而缺乏 ALA 的膳食则不会。多组织分析确定 13-HOTrE-γ 是暴露于 2-MCPD 的标志物。我们的研究为 2-MCPD 的毒性提供了有力的证据，证实了氧化脂在心脏中的功能性和指示性作用，并表明对化学危害的研究应使用充足的 n-3 PUFA 膳食。

{"title":"Cardiac oxylipin perturbances in response to 2-monochloropropane-1,3-diol exposure are ameliorated by dietary adequacy of the essential n-3 fatty acid, α-linolenic acid","authors":"Lucien GJ. Cayer , Tobias Karakach , Jennifer Roberts , Stephen PJ. Brooks , Jayadev Raju , Harold M. Aukema","doi":"10.1016/j.fct.2024.115080","DOIUrl":"10.1016/j.fct.2024.115080","url":null,"abstract":"<div><div>2-Monochloropropane-1,3-diol (2-MCPD) is a food contaminant with demonstrated cardiotoxicity in rats. This adverse effect was previously associated with lower anti-inflammatory docosahexaenoic acid (DHA)-derived cardiac oxylipins in F344 rats. This previous study utilized corn oil as the dietary lipid; we therefore investigated whether deficient (0.07 g/100 g diet) or adequate (0.5 g/100 g diet) dietary α-linolenic acid (ALA), the essential n-3 polyunsaturated fatty acid (PUFA), alters the oxylipin response in heart, liver, kidney, and serum of Sprague-Dawley rats exposed to 50 mg 2-MCPD/kg BW/day. ALA increased n-3 oxylipins in all tissues, reflecting greater n-3 PUFA substrate availability. In the heart, 2-MCPD increased cyclooxygenase-derived arachidonic acid oxylipins, conducive to inflammation. Adequate dietary ALA revealed 2-MCPD-induced reductions of anti-inflammatory cardiac DHA-derived oxylipins; these were not apparent in the ALA-deficient diet as these n-3 PUFA oxylipins were already reduced. Conversely, 2-MCPD increased cardiac 13-hydroxy-octadecatrienoic acid-γ (13-HOTrE-γ) levels with deficient, but not adequate, ALA diets. Multi-tissue analysis identified 13-HOTrE-γ as a marker of 2-MCPD exposure. Our study contributes to the weight-of-evidence of 2-MCPD toxicity, confirms the functional and indicative roles of oxylipins in the heart, and demonstrates that live bioassays determining chemical health hazards should use adequate n-3 PUFA diets.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115080"},"PeriodicalIF":3.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to “Predictive capabilities and limitations of non-animal methods for skin sensitization: Comments on the paper by Ruparel et al.” 对 "非动物皮肤过敏方法的预测能力和局限性：对 Ruparel 等人论文的评论"

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-01 DOI: 10.1016/j.fct.2024.115061

Nakul Ruparel

引用次数: 0

Roles of mTOR-p70S6K signaling pathway and HO-1 in ethylbenzene-induced hepatoxic effects in L02 cells mTOR-p70S6K信号通路和HO-1在乙苯诱导的L02细胞肝毒性效应中的作用

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-01 DOI: 10.1016/j.fct.2024.115086

Siyu Liu , Linlin Chen , Hui Peng , Qiang Zhang , Qiang Zeng , Bo Cui , Ming Zhang

Ethylbenzene (EB)-induced hepatotoxic effects has been indicated as oxidative damage and mitochondria-mediated apoptosis in vivo in our previous study, yet the mechanisms remain unclear. This study aimed to explore the role of the mTOR-p70S6K signaling pathway in EB-induced hepatoxic effects in vitro. Normal human hepatocytes (L02 cells) were exposed to different concentrations of ethylbenzene (0–10 mM) for 24 h. In vitro, we found that EB treatment decreased the viability of L02 cells, via inducing oxidative stress, mitochondrial impairments, excessive apoptosis and autophagy. These were accompanied by the inactivation of the mTOR-p70S6K signaling cascade, as manifested by the decreased levels of related molecules Atg family proteins and Heme oxygenase-1 (HO-1). These findings were further confirmed by mTOR inhibitor treatment and immunofluorescence analysis. Jointly, our results indicate that EB induces hepatoxic effects by triggering mitochondrial impairments and excess apoptosis and autophagy in L02 cells via suppressing the mTOR-p70S6K signaling, and oxidative stress affects the passive up-regulation of HO-1.

在我们之前的研究中，乙苯（EB）诱导的肝毒性效应被认为是体内氧化损伤和线粒体介导的细胞凋亡，但其机制仍不清楚。本研究旨在探讨 mTOR-p70S6K 信号通路在 EB 诱导的体外肝毒性效应中的作用。将正常人肝细胞（L02 细胞）暴露于不同浓度的乙苯（0-10 mM）中 24 小时。在体外，我们发现乙苯处理通过诱导氧化应激、线粒体损伤、过度凋亡和自噬，降低了 L02 细胞的活力。与此同时，mTOR-p70S6K 信号级联失活，表现为相关分子 Atg 家族蛋白和血红素加氧酶-1（HO-1）水平下降。mTOR 抑制剂处理和免疫荧光分析进一步证实了这些发现。综上所述，我们的研究结果表明，EB通过抑制mTOR-p70S6K信号传导，引发L02细胞线粒体损伤、过度凋亡和自噬，从而诱导肝毒性效应；氧化应激影响HO-1的被动上调。

{"title":"Roles of mTOR-p70S6K signaling pathway and HO-1 in ethylbenzene-induced hepatoxic effects in L02 cells","authors":"Siyu Liu , Linlin Chen , Hui Peng , Qiang Zhang , Qiang Zeng , Bo Cui , Ming Zhang","doi":"10.1016/j.fct.2024.115086","DOIUrl":"10.1016/j.fct.2024.115086","url":null,"abstract":"<div><div>Ethylbenzene (EB)-induced hepatotoxic effects has been indicated as oxidative damage and mitochondria-mediated apoptosis <em>in vivo</em> in our previous study, yet the mechanisms remain unclear. This study aimed to explore the role of the mTOR-p70S6K signaling pathway in EB-induced hepatoxic effects <em>in vitro</em>. Normal human hepatocytes (L02 cells) were exposed to different concentrations of ethylbenzene (0–10 mM) for 24 h. <em>In vitro</em>, we found that EB treatment decreased the viability of L02 cells, via inducing oxidative stress, mitochondrial impairments, excessive apoptosis and autophagy. These were accompanied by the inactivation of the mTOR-p70S6K signaling cascade, as manifested by the decreased levels of related molecules Atg family proteins and Heme oxygenase-1 (HO-1). These findings were further confirmed by mTOR inhibitor treatment and immunofluorescence analysis. Jointly, our results indicate that EB induces hepatoxic effects by triggering mitochondrial impairments and excess apoptosis and autophagy in L02 cells via suppressing the mTOR-p70S6K signaling, and oxidative stress affects the passive up-regulation of HO-1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115086"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatoprotective effects of the xanthine oxidase inhibitor Febuxostat against thioacetamide-induced liver injury in rats: The role of the Nrf2/ HO-1 and TLR4/ NF-κB pathways 黄嘌呤氧化酶抑制剂非布索坦对硫代乙酰胺诱导的大鼠肝损伤的保护作用：Nrf2/ HO-1 和 TLR4/ NF-κB 通路的作用。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-01 DOI: 10.1016/j.fct.2024.115087

Rehab S. Abdelrahman , Marwa E. Abdelmageed

Experimental models of liver injury have been established utilizing thioacetamide (TAA), a classic liver toxic chemical that causes organ damage via oxidative stress and inflammatory induction. This study examined the impact of Febuxostat (a xanthine oxidase inhibitor; Febu, 10–15 mg/kg, orally) against TAA (500 mg/kg, i.p.) -induced liver injury in rats.

Febu significantly attenuated TAA-induced alterations in liver function parameters, in addition to promoting hepatic antioxidant effects through a significant elevation of Heme-oxygenase-1(HO-1), nuclear factor erythroid 2-related factor2 (Nrf2), reduced glutathione (GSH) and superoxide dismutase (SOD) levels and reduction in hepatic malondialdehyde (MDA) content. Moreover, Febu improved the hepatic anti-inflammatory status by increasing the anti-inflammatory cytokine Interleukin (IL-10) level and reducing the levels of the pro-inflammatory cytokines (Nuclear factor kappa B (NF-κB), IL-1β, high-mobility group box1 (HMGB1), receptor for advanced glycation end products (RAGE), and toll-like receptor4 (TLR4) levels, in addition to suppressing the increased protein and mRNA expression levels of tumor necrosis factor alpha (TNF-α) and IL-6, hepatic expression of TNF-α and activated mitogen-activated protein kinases (p-JNK/p-p38 MAPK). Histopathologically, Febu markedly normalized TAA-induced alteration in liver sections. In conclusion, Febu, in a dose-dependent fashion, refines TAA-induced hepatotoxicity by enhancing antioxidant capabilities and decreasing inflammatory signals.

硫代乙酰胺（TAA）是一种典型的肝脏毒性化学物质，可通过氧化应激和炎症诱导造成器官损伤。本研究考察了非布索坦（一种黄嘌呤氧化酶抑制剂；非布，10-15 毫克/千克，口服）对TAA（500 毫克/千克，静注）诱导的大鼠肝损伤的影响。非布能明显减轻 TAA 引起的肝功能参数变化，此外，它还能促进肝脏抗氧化作用，明显提高血红素氧化酶-1（HO-1）、核因子红细胞 2 相关因子 2（Nrf2）、还原型谷胱甘肽（GSH）和超氧化物歧化酶（SOD）的水平，降低肝脏丙二醛（MDA）含量。此外，非布还能提高抗炎细胞因子白细胞介素（IL-10）的水平，降低促炎细胞因子（核因子卡巴B（NF-κB）、IL-1β、高迁移率基团框1（HMGB1））的水平，从而改善肝脏的抗炎状态、此外，非布还能抑制肿瘤坏死因子α（TNF-α）和 IL-6 蛋白及 mRNA 表达水平的升高、TNF-α 和活化的丝裂原活化蛋白激酶（p-JNK/ p-p38 MAPK）的肝脏表达。从组织病理学角度来看，非布能明显使 TAA 引起的肝脏切片改变正常化。总之，非布能通过增强抗氧化能力和减少炎症信号，以剂量依赖性的方式改善 TAA 诱导的肝毒性。

{"title":"Hepatoprotective effects of the xanthine oxidase inhibitor Febuxostat against thioacetamide-induced liver injury in rats: The role of the Nrf2/ HO-1 and TLR4/ NF-κB pathways","authors":"Rehab S. Abdelrahman , Marwa E. Abdelmageed","doi":"10.1016/j.fct.2024.115087","DOIUrl":"10.1016/j.fct.2024.115087","url":null,"abstract":"<div><div>Experimental models of liver injury have been established utilizing thioacetamide (TAA), a classic liver toxic chemical that causes organ damage via oxidative stress and inflammatory induction. This study examined the impact of Febuxostat (a xanthine oxidase inhibitor; Febu, 10–15 mg/kg, orally) against TAA (500 mg/kg, i.p.) -induced liver injury in rats.</div><div>Febu significantly attenuated TAA-induced alterations in liver function parameters, in addition to promoting hepatic antioxidant effects through a significant elevation of Heme-oxygenase-1(HO-1), nuclear factor erythroid 2-related factor2 (Nrf2), reduced glutathione (GSH) and superoxide dismutase (SOD) levels and reduction in hepatic malondialdehyde (MDA) content. Moreover, Febu improved the hepatic anti-inflammatory status by increasing the anti-inflammatory cytokine Interleukin (IL-10) level and reducing the levels of the pro-inflammatory cytokines (Nuclear factor kappa B (NF-κB), IL-1β, high-mobility group box1 (HMGB1), receptor for advanced glycation end products (RAGE), and toll-like receptor4 (TLR4) levels, in addition to suppressing the increased protein and mRNA expression levels of tumor necrosis factor alpha (TNF-α) and IL-6, hepatic expression of TNF-α and activated mitogen-activated protein kinases (p-JNK/p-p38 MAPK). Histopathologically, Febu markedly normalized TAA-induced alteration in liver sections. In conclusion, Febu, in a dose-dependent fashion, refines TAA-induced hepatotoxicity by enhancing antioxidant capabilities and decreasing inflammatory signals.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115087"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probabilistic health risk assessment of primary aromatic amines in polyamide cooking utensils in China by Monte Carlo simulation 通过蒙特卡罗模拟对中国聚酰胺厨具中的初级芳香胺进行概率健康风险评估。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-01 DOI: 10.1016/j.fct.2024.115067

Haoran Zhang , Daoyuan Yang , Jie Gao , Kai Qian , Hua Zhu , Yan Song , Haixia Sui , Weidong Hao

The migration of primary aromatic amines (PAAs) from food contact materials raises significant public health concerns. In this study, the migration levels of 26 PAAs were analyzed in 242 nylon cooking utensils using ultra-performance liquid chromatography-tandem mass spectrometry. A total of 18 PAAs were detected, of which 14 were quantified, with 4,4′-diaminodiphenylmethane (4,4′-MDA) and aniline being the most prevalent ones. The compliance rates for nylon kitchenware were similar under both legislation of European Commission (76.9%) and Chinese legislation (77.9%). Probabilistic non-carcinogenic and carcinogenic risk assessment were conducted using Monte Carlo simulation, with read-across approach applied to fill the gap of toxicity data. The hazard quotients for 18 PAAs were calculated, revealing that 17 PAAs (excluding 4,4′-MDA) had acceptable hazard quotients (<1). Lifetime cancer risks for 17 PAAs were determined, with 15 PAAs (excluding benzidine and 4,4′-MDA) showing acceptable cancer risks (<10⁻⁴). The study suggests that the non-carcinogenic and carcinogenic health risks posed by PAAs migrating from FCMs can be effectively mitigated by promptly identifying non-compliant products and reducing exposure to high-risk PAAs such as 4,4′-MDA and benzidine. Enhancing the understanding of PAA hazard characterization and implementing measures to minimize health risks associated with PAA migration from FCMs is hence recommended.

食品接触材料中芳香族伯胺（PAA）的迁移引起了公众的极大关注。本研究采用超高效液相色谱-串联质谱法分析了 242 种尼龙烹饪用具中 26 种 PAAs 的迁移水平。共检测到 18 种 PAAs，其中 14 种被定量，4,4'-二氨基二苯甲烷（4,4'-MDA）和苯胺是最常见的 PAAs。尼龙厨具在欧盟委员会法规（76.9%）和中国法规（77.9%）下的达标率相似。采用蒙特卡罗模拟法进行了非致癌和致癌风险的概率评估，并采用了读数交叉法来填补毒性数据的空白。研究计算了 18 种 PAAs 的危害商数，结果显示 17 种 PAAs（不包括 4,4'-MDA ）的危害商数（-4）是可以接受的。研究表明，通过及时发现不符合要求的产品，减少接触 4,4'-MDA 和联苯胺等高风险 PAA，可有效降低从含氟聚合物中迁移的 PAA 带来的非致癌和致癌健康风险。因此，建议加强对 PAA 危害特征的了解，并采取措施最大限度地降低与含氟聚合物中 PAA 迁移有关的健康风险。

{"title":"Probabilistic health risk assessment of primary aromatic amines in polyamide cooking utensils in China by Monte Carlo simulation","authors":"Haoran Zhang , Daoyuan Yang , Jie Gao , Kai Qian , Hua Zhu , Yan Song , Haixia Sui , Weidong Hao","doi":"10.1016/j.fct.2024.115067","DOIUrl":"10.1016/j.fct.2024.115067","url":null,"abstract":"<div><div>The migration of primary aromatic amines (PAAs) from food contact materials raises significant public health concerns. In this study, the migration levels of 26 PAAs were analyzed in 242 nylon cooking utensils using ultra-performance liquid chromatography-tandem mass spectrometry. A total of 18 PAAs were detected, of which 14 were quantified, with 4,4′-diaminodiphenylmethane (4,4′-MDA) and aniline being the most prevalent ones. The compliance rates for nylon kitchenware were similar under both legislation of European Commission (76.9%) and Chinese legislation (77.9%). Probabilistic non-carcinogenic and carcinogenic risk assessment were conducted using Monte Carlo simulation, with read-across approach applied to fill the gap of toxicity data. The hazard quotients for 18 PAAs were calculated, revealing that 17 PAAs (excluding 4,4′-MDA) had acceptable hazard quotients (<1). Lifetime cancer risks for 17 PAAs were determined, with 15 PAAs (excluding benzidine and 4,4′-MDA) showing acceptable cancer risks (<10<sup>−4</sup>). The study suggests that the non-carcinogenic and carcinogenic health risks posed by PAAs migrating from FCMs can be effectively mitigated by promptly identifying non-compliant products and reducing exposure to high-risk PAAs such as 4,4′-MDA and benzidine. Enhancing the understanding of PAA hazard characterization and implementing measures to minimize health risks associated with PAA migration from FCMs is hence recommended.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"193 ","pages":"Article 115067"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organochlorine pesticides and polybrominated diphenyl ethers in giant African snail from the Niger Delta, Nigeria: Implications for dietary exposure and health risk assessment 尼日利亚尼日尔三角洲非洲大蜗牛体内的有机氯农药和多溴二苯醚：对膳食暴露和健康风险评估的影响。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-10-31 DOI: 10.1016/j.fct.2024.115084

Chukwujindu M.A. Iwegbue , Uwomano Okosun , Loretta C. Overah , Ijeoma F. Ogwu , Eze W. Odali , Bice S. Martincigh

The concentrations of organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) were evaluated in snails from different locations in the Niger Delta of Nigeria to provide data about their sources and possible risk to humans from the consumption of snails. The OCP and PBDE concentrations in snail samples ranged from 0.31 to 12.2 ng g⁻¹ and 0.71 to 10.9 ng g⁻¹, respectively. The distribution patterns indicated the dominance of chlordanes and penta-BDEs for OCPs and PBDEs, respectively. The hazard index and total cancer risk values for human exposure to OCPs and PBDEs through consumption of these snails were less than 1 and 10⁻⁶ (acceptable risk values), respectively, indicating unlikely adverse health effects. The isomer ratios of OCPs in these snails reflected both historical and recent contamination, while the distribution patterns of PBDEs in these snails indicated sources linked to the use of the penta-BDE and octa-BDE formulations rather than the deca-BDE mixture in this region.

对尼日利亚尼日尔三角洲不同地点的蜗牛中有机氯农药（OCP）和多溴联苯醚（PBDE）的浓度进行了评估，以提供有关其来源以及食用蜗牛可能对人类造成的风险的数据。蜗牛样本中的 OCP 和 PBDE 浓度分别为 0.31 至 12.2 纳克 g-1 和 0.21 至 10.9 纳克 g-1。从分布模式来看，OCP 和 PBDE 的主要成分分别是氯丹和五溴二苯醚。人类通过食用这些螺类而摄入的 OCPs 和 PBDEs 的危害指数和癌症总风险值分别小于 1 和 10-6（可接受风险值），表明对健康造成不良影响的可能性不大。这些蜗牛中 OCPs 的异构体比率反映了历史和近期的污染情况，而这些蜗牛中 PBDEs 的分布模式表明，污染源与该地区使用的五溴二苯醚和八溴二苯醚制剂有关，而不是十溴二苯醚混合物。

{"title":"Organochlorine pesticides and polybrominated diphenyl ethers in giant African snail from the Niger Delta, Nigeria: Implications for dietary exposure and health risk assessment","authors":"Chukwujindu M.A. Iwegbue , Uwomano Okosun , Loretta C. Overah , Ijeoma F. Ogwu , Eze W. Odali , Bice S. Martincigh","doi":"10.1016/j.fct.2024.115084","DOIUrl":"10.1016/j.fct.2024.115084","url":null,"abstract":"<div><div>The concentrations of organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) were evaluated in snails from different locations in the Niger Delta of Nigeria to provide data about their sources and possible risk to humans from the consumption of snails. The OCP and PBDE concentrations in snail samples ranged from 0.31 to 12.2 ng g<sup>−1</sup> and 0.71 to 10.9 ng g<sup>−1</sup>, respectively. The distribution patterns indicated the dominance of chlordanes and penta-BDEs for OCPs and PBDEs, respectively. The hazard index and total cancer risk values for human exposure to OCPs and PBDEs through consumption of these snails were less than 1 and 10<sup>−6</sup> (acceptable risk values), respectively, indicating unlikely adverse health effects. The isomer ratios of OCPs in these snails reflected both historical and recent contamination, while the distribution patterns of PBDEs in these snails indicated sources linked to the use of the penta-BDE and octa-BDE formulations rather than the deca-BDE mixture in this region.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115084"},"PeriodicalIF":3.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological risk assessment of triadimenol for human exposure, broiler health, and food safety 三唑醇对人类暴露、肉鸡健康和食品安全的毒理学风险评估。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-10-30 DOI: 10.1016/j.fct.2024.115071

Yutong Tang, Ying Liu, Yongpeng Jin, Fude Zhang, Wanjun Zhang, Sunlin Luo, Jianjun Zang, Wenjun Yang, Yiqiang Chen

Triadimenol, a widely used triazole fungicide, leaves residues that pose risks to broiler health, food safety, and human health. Current studies focus on lab animals, leaving limited data regarding its impact on non-target organisms in agricultural ecosystems. Moreover, the doses in current studies often exceed typical agricultural pollution levels of triadimenol. Therefore, this study evaluates the toxic effects of triadimenol by exposing broilers to different concentrations (0.05–20 mg/kg) in their feed for 42 days, assessing growth performance, organ index, hematological parameters, histopathology, jejunum morphology, and tissue residues. The results show that triadimenol contamination at 0.05–20 mg/kg in feed does not significantly affect broiler growth performance. However, the significant changes in hematological parameters suggest the potential hematological toxicity of triadimenol in broilers. Triadimenol at 1 mg/kg or higher induces hepatotoxic and nephrotoxic effects, and significantly alters kidney organ index and histopathology in broilers. Additionally, when the triadimenol contamination level in feed exceeds 1 mg/kg, the residues in edible tissues of broilers exceed the limits set by the EU and China. Overall, our study indicates that even low-dose exposure to triadimenol poses potential risks, highlighting the need for strict regulation of its use in agriculture to protect food safety and human health.

三唑醇是一种广泛使用的三唑类杀菌剂，其残留物对肉鸡健康、食品安全和人类健康构成风险。目前的研究主要集中在实验室动物身上，有关三唑醇对农业生态系统中非目标生物影响的数据十分有限。此外，目前研究中的剂量往往超过三唑醇的典型农业污染水平。因此，本研究通过让肉鸡在不同浓度（0.05-20 毫克/千克）的饲料中暴露 42 天，评估三唑醇的毒性影响，包括生长性能、器官指数、血液学参数、组织病理学、空肠形态和组织残留。结果表明，在饲料中添加 0.05-20 毫克/千克的三唑醇不会显著影响肉鸡的生长性能。然而，血液学参数的明显变化表明，三唑醇对肉鸡有潜在的血液学毒性。1毫克/千克或更高剂量的三唑醇会诱发肝毒性和肾毒性效应，并显著改变肉鸡的肾脏器官指数和组织病理学。此外，当饲料中的三唑醇污染水平超过 1 毫克/千克时，肉鸡可食用组织中的残留量会超过欧盟和中国规定的限值。总之，我们的研究表明，即使低剂量接触三唑醇也会带来潜在风险，这突出表明有必要严格监管三唑醇在农业中的使用，以保护食品安全和人类健康。

{"title":"Toxicological risk assessment of triadimenol for human exposure, broiler health, and food safety","authors":"Yutong Tang, Ying Liu, Yongpeng Jin, Fude Zhang, Wanjun Zhang, Sunlin Luo, Jianjun Zang, Wenjun Yang, Yiqiang Chen","doi":"10.1016/j.fct.2024.115071","DOIUrl":"10.1016/j.fct.2024.115071","url":null,"abstract":"<div><div>Triadimenol, a widely used triazole fungicide, leaves residues that pose risks to broiler health, food safety, and human health. Current studies focus on lab animals, leaving limited data regarding its impact on non-target organisms in agricultural ecosystems. Moreover, the doses in current studies often exceed typical agricultural pollution levels of triadimenol. Therefore, this study evaluates the toxic effects of triadimenol by exposing broilers to different concentrations (0.05–20 mg/kg) in their feed for 42 days, assessing growth performance, organ index, hematological parameters, histopathology, jejunum morphology, and tissue residues. The results show that triadimenol contamination at 0.05–20 mg/kg in feed does not significantly affect broiler growth performance. However, the significant changes in hematological parameters suggest the potential hematological toxicity of triadimenol in broilers. Triadimenol at 1 mg/kg or higher induces hepatotoxic and nephrotoxic effects, and significantly alters kidney organ index and histopathology in broilers. Additionally, when the triadimenol contamination level in feed exceeds 1 mg/kg, the residues in edible tissues of broilers exceed the limits set by the EU and China. Overall, our study indicates that even low-dose exposure to triadimenol poses potential risks, highlighting the need for strict regulation of its use in agriculture to protect food safety and human health.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115071"},"PeriodicalIF":3.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 2-butyl-4,4,6-trimethyl-1,3-dioxane, CAS registry number 54546-26-8 RIFM 香料成分安全评估，2-丁基-4,4,6-三甲基-1,3-二恶烷，化学文摘社登记号 54546-26-8

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-10-28 DOI: 10.1016/j.fct.2024.115072

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Freidrich , G.A. Burton , M.A. Cancellieri , H. Chon , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , M. Lavelle , I. Lee , H. Moustakas , Y. Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 1-(2-tert-butyl cyclohexyloxy)-2-butanol, CAS Registry Number 139504-68-0 RIFM 香料成分安全评估更新，1-(2-叔丁基环己氧基)-2-丁醇，化学文摘社登记号 139504-68-0

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-10-26 DOI: 10.1016/j.fct.2024.115075

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , M. Lavelle , I. Lee , H. Moustakas , Y. Tokura

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Food and Chemical Toxicology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀