Food and Chemical Toxicology最新文献_第6页

Update to RIFM fragrance ingredient safety assessment, 6-isopropyl-2(1H)-octahydronaphthalenone, CAS Registry Number 34131-98-1 更新RIFM香料成分安全性评估，6-异丙基-2(1H)-八氢萘酮，CAS注册号34131-98-1。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-14 DOI: 10.1016/j.fct.2026.115939

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, ethyl 3-phenylglycidate, CAS Registry Number 121-39-1 香料成分安全性评价，3-苯基甘氨酸乙酯，CAS注册号121-39-1。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-14 DOI: 10.1016/j.fct.2026.115943

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, 2-methyl-3-tolylpropionaldehyde, CAS Registry Number 41496-43-9 香料成分安全性评价，2-甲基-3-甲基丙醛，中国科学院注册号41496-43-9。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-14 DOI: 10.1016/j.fct.2026.115942

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 3,7-dimethyl-2,6-nonadien-1-al, CAS Registry Number 41448-29-7 更新RIFM香料成分安全性评估，3,7-二甲基-2,6-壬二烯-1-al， CAS注册号41448-29-7。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-14 DOI: 10.1016/j.fct.2026.115947

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Korean dioxin risk patterns: Modulation by dietary-socio-demographic and behavioral factors 韩国二恶英风险模式：饮食-社会人口和行为因素的调节。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-14 DOI: 10.1016/j.fct.2026.115953

Dongjun Lee , Kyungjun Jeong , Jeongho Oh , Changsoo Kim , Seungyoung Park , Yongjin Lee

Background

Dioxins, well-known persistent organic pollutants, accumulate in the human body primarily through dietary exposure. However, it may be significant to examine the current status of dioxin risk in relation to physiological factors, lifestyle factors, and socioeconomic conditions with dietary patterns.

Objectives

This study aimed to identify the non-carcinogenic dioxin risk patterns according to physiological, socioeconomic, lifestyle, and dietary factors.

Methods

Physiological, socioeconomic, lifestyle, and dietary factors were surveyed for 153 Korean adults (aged 20–59) living in metropolitan areas. 29 dioxin congeners were analyzed in serum samples. The estimated daily dioxin intake was calculated by combining the surveyed dietary consumption data with the dioxin concentrations provided by the Ministry of Food and Drug Safety of Korea. The non-carcinogenic risk from comparing the estimated intake with WHO TDI value was classified into surveyed factors. The association between dietary intake and blood dioxin concentrations was evaluated using a generalized linear model.

Results

Females exhibited a higher risk than males, and the risk increased with advancing age. Current smokers showed a lower risk compared to non-smokers and former smokers, while participants with a history of disease demonstrated a notably lower risk than those without such a history. Furthermore, higher monthly income was associated with an increased risk, whereas higher educational attainment was inversely associated with risk. Shellfish was associated with increasing blood DL-PCBs levels.

Conclusion

Socio-demographic and behavioral factors may play an important role in modulating the non-carcinogenic risk associated with dietary dioxin exposure. Changes in dioxin risk patterns across such factors warrant further examination through additional investigation.

背景：二恶英是一种众所周知的持久性有机污染物，主要通过饮食接触在人体内积累。然而，检查二恶英风险的现状与生理因素、生活方式因素和社会经济条件与饮食模式的关系可能是有意义的。目的：本研究旨在根据生理、社会经济、生活方式和饮食因素确定非致癌性二恶英的风险模式。方法：对居住在首都地区的153名韩国成年人（20-59岁）的生理、社会经济、生活方式和饮食因素进行调查。血清样品中分析了29种二恶英同系物。估计的每日二恶英摄入量是将调查的饮食消费数据与韩国食品药品安全处提供的二恶英浓度相结合计算得出的。将估计摄入量与世界卫生组织TDI值进行比较得出的非致癌风险被分类为调查因素。膳食摄入量与血液二恶英浓度之间的关系使用广义线性模型进行评估。结果：女性患病风险高于男性，且随年龄增长而增加。与不吸烟者和前吸烟者相比，目前吸烟者的风险较低，而有病史的参与者的风险明显低于没有病史的参与者。此外，较高的月收入与风险增加有关，而较高的教育程度与风险呈负相关。贝类与血液中多氯联苯水平升高有关。结论：社会人口和行为因素可能在调节饮食中二恶英暴露相关的非致癌风险中起重要作用。这些因素之间二恶英风险模式的变化需要通过额外的调查进一步检查。

{"title":"Korean dioxin risk patterns: Modulation by dietary-socio-demographic and behavioral factors","authors":"Dongjun Lee , Kyungjun Jeong , Jeongho Oh , Changsoo Kim , Seungyoung Park , Yongjin Lee","doi":"10.1016/j.fct.2026.115953","DOIUrl":"10.1016/j.fct.2026.115953","url":null,"abstract":"<div><h3>Background</h3><div>Dioxins, well-known persistent organic pollutants, accumulate in the human body primarily through dietary exposure. However, it may be significant to examine the current status of dioxin risk in relation to physiological factors, lifestyle factors, and socioeconomic conditions with dietary patterns.</div></div><div><h3>Objectives</h3><div>This study aimed to identify the non-carcinogenic dioxin risk patterns according to physiological, socioeconomic, lifestyle, and dietary factors.</div></div><div><h3>Methods</h3><div>Physiological, socioeconomic, lifestyle, and dietary factors were surveyed for 153 Korean adults (aged 20–59) living in metropolitan areas. 29 dioxin congeners were analyzed in serum samples. The estimated daily dioxin intake was calculated by combining the surveyed dietary consumption data with the dioxin concentrations provided by the Ministry of Food and Drug Safety of Korea. The non-carcinogenic risk from comparing the estimated intake with WHO TDI value was classified into surveyed factors. The association between dietary intake and blood dioxin concentrations was evaluated using a generalized linear model.</div></div><div><h3>Results</h3><div>Females exhibited a higher risk than males, and the risk increased with advancing age. Current smokers showed a lower risk compared to non-smokers and former smokers, while participants with a history of disease demonstrated a notably lower risk than those without such a history. Furthermore, higher monthly income was associated with an increased risk, whereas higher educational attainment was inversely associated with risk. Shellfish was associated with increasing blood DL-PCBs levels.</div></div><div><h3>Conclusion</h3><div>Socio-demographic and behavioral factors may play an important role in modulating the non-carcinogenic risk associated with dietary dioxin exposure. Changes in dioxin risk patterns across such factors warrant further examination through additional investigation.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115953"},"PeriodicalIF":3.5,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isopulegyl acetate, CAS Registry number 57576-09-7 更新RIFM香料成分安全性评估，醋酸异戊酯，CAS注册号57576-09-7。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-14 DOI: 10.1016/j.fct.2026.115944

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Safety evaluation of pasteurized Akkermansia muciniphila YGMCC2645 巴氏灭菌的嗜粘阿克曼菌YGMCC2645的安全性评价

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-13 DOI: 10.1016/j.fct.2026.115940

Jie Tian , Zhili He , Minlei Zhao , Xianghong Ke , Yinjing Zhang , Jingjing Qu , Ying Xia , Shaohua Fu , Wenxiang Yang , Lanjie Pei , Jun Fan , Jianguo Chen , Bolin Fan

Due to the potential benefits of Akkermansia muciniphila (A. muciniphila) to humans, it is considered a promising next-generation probiotic. To better develop and utilise A. muciniphila, a systematic safety assessment is necessary. This study involved conducting a series of tests to determine the safety of pasteurized A. muciniphila YGMCC2645. Results were shown that there was no antibiotic-resistance, virulence, and pathogenicity genes in the YGMCC2645. The LD₅₀ of acute oral toxicity in rats was greater than 10.0 g/kg BW (3.0 × 10¹² TFU/kg BW). No genotoxicity was found in the Ames test, the chromosome aberration mammalian assay, or the erythrocyte micronucleus assay. In the 90-day oral toxicity (with a dose of up to 2.5 × 10¹¹ TFU/kg BW), no treatment–related toxicological changes were observed in terms of body weight, food intake, food efficiency, hematological and biochemical indexes, urine indexes, and pathological indexes. In terms of teratogenic toxicity, there were no significant differences in the reproductive parameters of pregnant rats and developmental parameters of fetal rats. These results supported A. muciniphila YGMCC2645 is safe for use as a food ingredient.

由于嗜muciniphila （a.m uiniphila）对人类的潜在益处，它被认为是有前途的下一代益生菌。为了更好地开发和利用嗜粘单胞菌，有必要进行系统的安全性评价。本研究进行了一系列试验，以确定巴氏灭菌的嗜粘杆菌YGMCC2645的安全性。结果表明，YGMCC2645不存在耐药基因、毒力基因和致病性基因。大鼠急性口服毒性LD50大于10.0 g/kg BW （3.0 × 1012 TFU/kg BW）。Ames试验、哺乳动物染色体畸变试验或红细胞微核试验均未发现遗传毒性。在90天的口服毒性（剂量高达2.5 × 1011 TFU/kg BW）中，在体重、摄食量、食物效率、血液生化指标、尿液指标和病理指标方面均未观察到与治疗相关的毒理学变化。在致畸毒性方面，妊娠大鼠生殖参数和胎鼠发育参数无显著差异。这些结果支持嗜粘液芽孢杆菌YGMCC2645作为食品原料是安全的。

{"title":"Safety evaluation of pasteurized Akkermansia muciniphila YGMCC2645","authors":"Jie Tian , Zhili He , Minlei Zhao , Xianghong Ke , Yinjing Zhang , Jingjing Qu , Ying Xia , Shaohua Fu , Wenxiang Yang , Lanjie Pei , Jun Fan , Jianguo Chen , Bolin Fan","doi":"10.1016/j.fct.2026.115940","DOIUrl":"10.1016/j.fct.2026.115940","url":null,"abstract":"<div><div>Due to the potential benefits of <em>Akkermansia muciniphila</em> (<em>A. muciniphila</em>) to humans, it is considered a promising next-generation probiotic. To better develop and utilise <em>A. muciniphila</em>, a systematic safety assessment is necessary. This study involved conducting a series of tests to determine the safety of pasteurized <em>A. muciniphila</em> YGMCC2645. Results were shown that there was no antibiotic-resistance, virulence, and pathogenicity genes in the YGMCC2645. The LD<sub>50</sub> of acute oral toxicity in rats was greater than 10.0 g/kg BW (3.0 × 10<sup>12</sup> TFU/kg BW). No genotoxicity was found in the Ames test, the chromosome aberration mammalian assay, or the erythrocyte micronucleus assay. In the 90-day oral toxicity (with a dose of up to 2.5 × 10<sup>11</sup> TFU/kg BW), no treatment–related toxicological changes were observed in terms of body weight, food intake, food efficiency, hematological and biochemical indexes, urine indexes, and pathological indexes. In terms of teratogenic toxicity, there were no significant differences in the reproductive parameters of pregnant rats and developmental parameters of fetal rats. These results supported <em>A. muciniphila</em> YGMCC2645 is safe for use as a food ingredient.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115940"},"PeriodicalIF":3.5,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, citral, CAS Registry Number 5392-40-5 更新RIFM香精成分安全评估，柠檬醛，CAS注册号5392-40-5。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-13 DOI: 10.1016/j.fct.2026.115950

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6 更新RIFM香料成分安全性评估，1,6-辛二烯-3-醇，3,7-二甲基，酸异构化，CAS注册号73018-51-6。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-13 DOI: 10.1016/j.fct.2026.115937

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not genotoxic. Data on 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints. Data show that there are no safety concerns for 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is below the TTC (0.47 mg/day). The environmental endpoints were evaluated; 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

评价1,6-八烯二烯-3-醇3,7-二甲基酸异构化的遗传毒性、重复剂量毒性、生殖毒性、局部呼吸毒性、光刺激/光致敏性、皮肤致敏性和环境安全性。数据显示1,6-辛二烯-3-醇3,7-二甲基酸异构化无遗传毒性。1,6-辛二烯-3-醇3,7-二甲基酸异构化的数据为重复剂量毒性和生殖毒性终点提供了计算的暴露边际（MOE） bb100。数据显示，在目前申报的使用水平下，1,6-辛二烯-3-醇，3,7-二甲基-酸异构化对皮肤致敏没有安全问题。根据紫外线（UV）光谱评估光刺激/光致敏终点；1,6-辛二烯-3-醇3,7-二甲基酸异构化预计不会引起光刺激/光过敏。使用克莱默III类材料的毒理学关注阈值（TTC）评估局部呼吸毒性终点，暴露于1,6-辛二烯-3-醇，3,7-二甲基-酸异构化低于TTC （0.47 mg/天）。评估环境终点；根据国际香精协会（IFRA）环境标准，1,6-辛二烯-3-醇3,7-二甲基-酸异构化被发现不具有持久性，生物蓄积性和毒性（PBT），其风险商数基于其在欧洲和北美的当前使用量（VoU）（即预测环境浓度/预测无影响浓度[PEC/PNEC]）为

{"title":"Update to RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6","authors":"A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar","doi":"10.1016/j.fct.2026.115937","DOIUrl":"10.1016/j.fct.2026.115937","url":null,"abstract":"<div><div>1,6-Octadien-3-ol, 3,7-dimethyl-, acid-isomerized was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not genotoxic. Data on 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints. Data show that there are no safety concerns for 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized is below the TTC (0.47 mg/day). The environmental endpoints were evaluated; 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115937"},"PeriodicalIF":3.5,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender-specific gut microbiota alterations in adolescent C57BL/6 mice following prenatal alcohol exposure 产前酒精暴露后青春期C57BL/6小鼠性别特异性肠道微生物群的改变

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2026-01-12 DOI: 10.1016/j.fct.2026.115929

Simone Baldi , Sara Bertorello , Francesco Cei , Antonino Iurato La Rocca , Valentina Scianaro , Gianluca Bartolucci , Guido Mannaioni , Amedeo Amedei , Elisabetta Gerace

Fetal Alcohol Spectrum Disorder (FASD), caused by prenatal alcohol exposure (PAE), produces lasting physical, cognitive, and behavioral impairments. The present study examined effects of early PAE on the gut microbiome (GM) in adolescent mice to identify targets for early intervention. Female C57Bl/6 dams received 10 % ethanol during the first 10 days of gestation while controls received water. Fecal and blood samples from adolescent offspring were profiled by 16S rRNA sequencing and gas chromatography-mass spectrometry to characterize microbial composition and short-chain fatty acids (SCFAs). PAE reduced microbial alpha diversity and produced distinct beta diversity patterns versus controls. Metabolomic profiling revealed increased fecal acetate and reduced anti-inflammatory SCFAs in PAE mice, though circulating SCFA levels remained unchanged. Sex-stratified analyses showed that these alterations were driven predominantly by males, who exhibited greater microbial and metabolic disruptions, enrichment of pro-inflammatory genera (Parasutterella, Parabacteroides, Clostridioides), and elevated serum medium-chain fatty acids. Cluster analysis of PAE males identified a dysbiotic subgroup with severe alpha diversity loss, increased pro-inflammatory taxa, diminished beneficial SCFAs, and enrichment of catabolic and fatty acid biosynthesis pathways. Together, the results reveal sex- and individual-specific susceptibility to PAE-induced GM dysbiosis and justify further mechanistic studies to develop sex-tailored microbiota-targeted strategies for FASD.

胎儿酒精谱系障碍（FASD）是由产前酒精暴露（PAE）引起的，会产生持久的身体、认知和行为障碍。本研究检测了早期PAE对青春期小鼠肠道微生物组（GM）的影响，以确定早期干预的目标。雌性C57Bl/6在妊娠前10天接受10%的乙醇治疗，而对照组接受水治疗。采用16S rRNA测序和气相色谱-质谱联用技术对青春期后代的粪便和血液样本进行分析，以确定微生物组成和短链脂肪酸（SCFAs）的特征。与对照组相比，PAE降低了微生物的α多样性，并产生了明显的β多样性模式。代谢组学分析显示，PAE小鼠的粪便乙酸增加，抗炎SCFA减少，但循环SCFA水平保持不变。性别分层分析表明，这些改变主要是由男性驱动的，他们表现出更大的微生物和代谢破坏，促炎属（Parasutterella, Parabacteroides, clostridiides）的富集，血清中链脂肪酸升高。聚类分析发现，PAE雄性动物的α多样性严重丧失，促炎类群增加，有益scfa减少，分解代谢和脂肪酸生物合成途径富集。总之，结果揭示了性别和个体对pae诱导的转基因生态失调的特异性易感性，并证明了进一步的机制研究，以开发针对性别的针对FASD的微生物群策略。

{"title":"Gender-specific gut microbiota alterations in adolescent C57BL/6 mice following prenatal alcohol exposure","authors":"Simone Baldi , Sara Bertorello , Francesco Cei , Antonino Iurato La Rocca , Valentina Scianaro , Gianluca Bartolucci , Guido Mannaioni , Amedeo Amedei , Elisabetta Gerace","doi":"10.1016/j.fct.2026.115929","DOIUrl":"10.1016/j.fct.2026.115929","url":null,"abstract":"<div><div>Fetal Alcohol Spectrum Disorder (FASD), caused by prenatal alcohol exposure (PAE), produces lasting physical, cognitive, and behavioral impairments. The present study examined effects of early PAE on the gut microbiome (GM) in adolescent mice to identify targets for early intervention. Female C57Bl/6 dams received 10 % ethanol during the first 10 days of gestation while controls received water. Fecal and blood samples from adolescent offspring were profiled by 16S rRNA sequencing and gas chromatography-mass spectrometry to characterize microbial composition and short-chain fatty acids (SCFAs). PAE reduced microbial alpha diversity and produced distinct beta diversity patterns versus controls. Metabolomic profiling revealed increased fecal acetate and reduced anti-inflammatory SCFAs in PAE mice, though circulating SCFA levels remained unchanged. Sex-stratified analyses showed that these alterations were driven predominantly by males, who exhibited greater microbial and metabolic disruptions, enrichment of pro-inflammatory genera (<em>Parasutterella</em>, <em>Parabacteroides</em>, <em>Clostridioides</em>), and elevated serum medium-chain fatty acids. Cluster analysis of PAE males identified a dysbiotic subgroup with severe alpha diversity loss, increased pro-inflammatory taxa, diminished beneficial SCFAs, and enrichment of catabolic and fatty acid biosynthesis pathways. Together, the results reveal sex- and individual-specific susceptibility to PAE-induced GM dysbiosis and justify further mechanistic studies to develop sex-tailored microbiota-targeted strategies for FASD.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115929"},"PeriodicalIF":3.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0