Food and Chemical Toxicology最新文献_第2页

RIFM fragrance ingredient safety assessment, 4-(4,8-dimethylnona-3,7-dienyl)pyridine, CAS Registry Number 38462-23-6. RIFM 香料成分安全评估，4-(4,8-二甲基壬-3,7-二烯基)吡啶，化学文摘社登记号 38462-23-6。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-13 DOI: 10.1016/j.fct.2024.115109

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

Effects of a Cyperus esculentus L. plant-based beverage on FVB/n female mice 香附植物饮料对 FVB/n 雌性小鼠的影响

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-12 DOI: 10.1016/j.fct.2024.115082

Filipa A. Fernandes , Paula A. Oliveira , Maria L. Pinto , Carlos Venâncio , Luis Félix , Beatriz Medeiros-Fonseca , Rossana Correia , Miguel A. Prieto , Isabel C.F.R. Ferreira , Lillian Barros , Sandrina A. Heleno

This work evaluated the effects of the consumption of a plant-based beverage (Cyperus esculentus L., Adansonia digitata L., and thermal water) on the physiological parameters of mice over a 28-day period. Thirty-two female FVB/n mice (n = 8) were randomly assigned to one of four groups divided into two experimental protocols: Group 1 drank water and Group 2 drank a plant-based beverage for 24 h; in the second experimental protocol, Group 3 consumed water and Group 4 consumed plant-based beverage for a limited time (4 h). Two experimental protocols were conducted to assess whether the exposure time to the beverage affects the animals' physiological parameters, to determine if there is a possible daily limit for consumption of the product and to analyze their adverse effects. The mice consuming a beverage ingested a larger amount of drink and a smaller amount of food. Histologically there are no pathological changes in collected organs. The consumption of a plant-based beverage has been shown to have a positive effect on oxidative markers and can have a diuretic action. According to results, no behavioral changes or clinical signs of disease were observed throughout both experimental protocols, and no mortality was recorded.

本研究评估了在 28 天内饮用植物饮料（香附、猴面包树和温泉水）对小鼠生理参数的影响。32只雌性FVB/n小鼠（n = 8）被随机分配到四个组中的一组，分为两个实验方案：第一组喝水，第二组喝植物饮料，持续 24 小时；在第二个实验方案中，第三组喝水，第四组在有限的时间内（4 小时）喝植物饮料。进行两个实验方案的目的是评估接触饮料的时间是否会影响动物的生理参数，确定每天饮用该产品是否有可能的限制，并分析其不良影响。饮用饮料的小鼠摄入了较多的饮料和较少的食物。从组织学角度看，采集的器官没有发生病理变化。研究表明，饮用植物饮料对氧化指标有积极影响，并有利尿作用。结果表明，在两个实验方案中都没有观察到行为变化或疾病的临床症状，也没有死亡记录。

{"title":"Effects of a Cyperus esculentus L. plant-based beverage on FVB/n female mice","authors":"Filipa A. Fernandes , Paula A. Oliveira , Maria L. Pinto , Carlos Venâncio , Luis Félix , Beatriz Medeiros-Fonseca , Rossana Correia , Miguel A. Prieto , Isabel C.F.R. Ferreira , Lillian Barros , Sandrina A. Heleno","doi":"10.1016/j.fct.2024.115082","DOIUrl":"10.1016/j.fct.2024.115082","url":null,"abstract":"<div><div>This work evaluated the effects of the consumption of a plant-based beverage (<em>Cyperus esculentus</em> L., <em>Adansonia digitata</em> L., and thermal water) on the physiological parameters of mice over a 28-day period. Thirty-two female FVB/n mice (n = 8) were randomly assigned to one of four groups divided into two experimental protocols: Group 1 drank water and Group 2 drank a plant-based beverage for 24 h; in the second experimental protocol, Group 3 consumed water and Group 4 consumed plant-based beverage for a limited time (4 h). Two experimental protocols were conducted to assess whether the exposure time to the beverage affects the animals' physiological parameters, to determine if there is a possible daily limit for consumption of the product and to analyze their adverse effects. The mice consuming a beverage ingested a larger amount of drink and a smaller amount of food. Histologically there are no pathological changes in collected organs. The consumption of a plant-based beverage has been shown to have a positive effect on oxidative markers and can have a diuretic action. According to results, no behavioral changes or clinical signs of disease were observed throughout both experimental protocols, and no mortality was recorded.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115082"},"PeriodicalIF":3.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of hexafluoropropylene oxide trimer acid (HFPO-TA) on sex differentiation after exposures during different development stages of zebrafish (Danio rerio) 斑马鱼（Danio rerio）不同发育阶段接触六氟环氧丙烷三聚酸（HFPO-TA）后对性别分化的影响。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-12 DOI: 10.1016/j.fct.2024.115108

Shasha Dong , Jianhui Xu , Xianghan Meng, Xiangyue Jiang, Dan Yang, Xiaohui Zhao, Xiaoying Li, Guanghui Ding

Hexafluoropropylene oxide trimer acid (HFPO-TA), a novel alternative to perfluorooctanoic acid (PFOA), has been widely used and ubiquitously detected in aquatic environments. However, its potential effects on sex differentiation of aquatic organisms are not well known. Therefore, in this study, zebrafish were exposed to HFPO-TA at different development stages (0–21, 21–42, and 42–63 dpf) to investigate the effects on sex differentiation and its underlying mechanisms. All three exposures to HFPO-TA resulted in the feminization of zebrafish, and the impact of Stage II was most significant. The transcription levels of key genes related to female differentiation (bpm15, cyp19a1a, esr1, vtg1, and sox9b) were up-regulated, while those of key genes related to male differentiation (dmrt1, gata4, amh, and sox9a) were down-regulated, which could lead to the feminization. In addition, it was found that the dysregulations of these genes were prolonged in adult zebrafish even through a long recovery, which could cause sex imbalance in populations. Therefore, HFPO-TA might not be a safe alternative to PFOA, and more evidences from multi- and transgenerational toxicology are warranted.

六氟环氧丙烷三聚酸（HFPO-TA）是全氟辛酸（PFOA）的一种新型替代品，已被广泛使用并在水生环境中普遍检测到。然而，人们对其对水生生物性别分化的潜在影响还不甚了解。因此，在本研究中，斑马鱼在不同的发育阶段（0-21、21-42 和 42-63 dpf）暴露于 HFPO-TA，以研究其对性别分化的影响及其内在机制。暴露于 HFPO-TA 的三个阶段都会导致斑马鱼雌性化，其中第二阶段的影响最为显著。与雌性分化相关的关键基因（bpm15、cyp19a1a、esr1、vtg1和sox9b）的转录水平被上调，而与雄性分化相关的关键基因（dmrt1、gata4、amh和sox9a）的转录水平被下调，这可能会导致雌性化。此外，研究还发现，这些基因的失调在成年斑马鱼体内即使经过长期恢复也会持续，这可能会导致种群性别失衡。因此，HFPO-TA 可能不是全氟辛烷磺酸的安全替代品，还需要更多的多代和跨代毒理学证据。

{"title":"Impact of hexafluoropropylene oxide trimer acid (HFPO-TA) on sex differentiation after exposures during different development stages of zebrafish (Danio rerio)","authors":"Shasha Dong , Jianhui Xu , Xianghan Meng, Xiangyue Jiang, Dan Yang, Xiaohui Zhao, Xiaoying Li, Guanghui Ding","doi":"10.1016/j.fct.2024.115108","DOIUrl":"10.1016/j.fct.2024.115108","url":null,"abstract":"<div><div>Hexafluoropropylene oxide trimer acid (HFPO-TA), a novel alternative to perfluorooctanoic acid (PFOA), has been widely used and ubiquitously detected in aquatic environments. However, its potential effects on sex differentiation of aquatic organisms are not well known. Therefore, in this study, zebrafish were exposed to HFPO-TA at different development stages (0–21, 21–42, and 42–63 dpf) to investigate the effects on sex differentiation and its underlying mechanisms. All three exposures to HFPO-TA resulted in the feminization of zebrafish, and the impact of Stage II was most significant. The transcription levels of key genes related to female differentiation (<em>bpm15</em>, <em>cyp19a1a</em>, <em>esr1</em>, <em>vtg1</em>, and <em>sox9b</em>) were up-regulated, while those of key genes related to male differentiation (<em>dmrt1</em>, <em>gata4</em>, <em>amh</em>, and <em>sox9a</em>) were down-regulated, which could lead to the feminization. In addition, it was found that the dysregulations of these genes were prolonged in adult zebrafish even through a long recovery, which could cause sex imbalance in populations. Therefore, HFPO-TA might not be a safe alternative to PFOA, and more evidences from multi- and transgenerational toxicology are warranted.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115108"},"PeriodicalIF":3.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited uptake of [¹⁴C]Gardenia Blue administered orally in male and female rats and mice. 雄性和雌性大鼠及小鼠对口服[14C]栀子蓝的吸收有限。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-11 DOI: 10.1016/j.fct.2024.115107

Timothy R Fennell, Sherry R Black, Phyllis Elkins, Rodney Snyder, Ryo Ishibashi, Mihoko Koyanagi, Shim-Mo Hayashi

Gardenia blue (GB), a widely used plant-derived food color is prepared by reaction of genipin, the aglycone of geniposide, with protein hydrolysate. Recent animal studies investigating GB toxicity have indicated blue coloration in the gastrointestinal tract, kidneys and mesenteric lymph nodes in rodents following dietary administration. This study investigated the uptake and disposition of [¹⁴C]GB in male and female rats and mice administered 100 or 1000 mg/kg by gavage. [¹⁴C]GB was prepared by reaction of [2-¹⁴C]genipin with soy protein hydrolysate. Following administration in rats, ¹⁴C was eliminated primarily in feces (89-97% of administered dose), exhaled volatile organic chemical (VOC) and CO₂ traps contained no radioactivity, and urine contained 0.2-0.4 %. In bile-duct-cannulated rats (100 mg/kg [¹⁴C]GB), 0.25% of dose was recovered in bile, and in urine, 0.5%. The percent of the dose absorbed was 0.9%, based on radioactivity in urine, bile, and carcass minus digestive tract contents. The highest level of radioactivity in tissues was in kidney; however renal recovery was low, with only 0.02-0.04% of the dose recovered in kidney. Repeated dosing indicated that ¹⁴C accumulated in kidney, and was slowly removed following cessation of dosing, consistent with previous studies, in the absence of any functional or histopathological changes.

栀子蓝（GB）是一种广泛使用的植物性食用色素，是由玄甙的苷元与蛋白质水解物反应制备而成。最近有关 GB 毒性的动物研究表明，啮齿类动物通过饮食摄入 GB 后，胃肠道、肾脏和肠系膜淋巴结会呈现蓝色。本研究调查了雄性和雌性大鼠和小鼠通过灌胃给药 100 或 1000 毫克/千克[14C]GB 的吸收和处置情况。[14C]GB 是由 [2-14C]genipin 与大豆蛋白水解物反应制备而成。大鼠给药后，14C 主要通过粪便排出（占给药剂量的 89-97%），呼出的挥发性有机化学物质（VOC）和二氧化碳捕集器不含放射性，尿液中的 14C 含量为 0.2-0.4%。在胆管封闭的大鼠体内（100 毫克/千克 [14C]GB ），剂量的 0.25% 在胆汁中被回收，0.5% 在尿液中被回收。根据尿液、胆汁和胴体中的放射性减去消化道内容物，吸收的剂量百分比为 0.9%。组织中放射性水平最高的是肾脏；但肾脏的回收率很低，只有 0.02-0.04% 的剂量在肾脏中被回收。重复给药表明，14C 在肾脏中积累，并在停止给药后缓慢排出，这与之前的研究结果一致，且未出现任何功能或组织病理学变化。

{"title":"Limited uptake of [<sup>14</sup>C]Gardenia Blue administered orally in male and female rats and mice.","authors":"Timothy R Fennell, Sherry R Black, Phyllis Elkins, Rodney Snyder, Ryo Ishibashi, Mihoko Koyanagi, Shim-Mo Hayashi","doi":"10.1016/j.fct.2024.115107","DOIUrl":"https://doi.org/10.1016/j.fct.2024.115107","url":null,"abstract":"<p><p>Gardenia blue (GB), a widely used plant-derived food color is prepared by reaction of genipin, the aglycone of geniposide, with protein hydrolysate. Recent animal studies investigating GB toxicity have indicated blue coloration in the gastrointestinal tract, kidneys and mesenteric lymph nodes in rodents following dietary administration. This study investigated the uptake and disposition of [<sup>14</sup>C]GB in male and female rats and mice administered 100 or 1000 mg/kg by gavage. [<sup>14</sup>C]GB was prepared by reaction of [2-<sup>14</sup>C]genipin with soy protein hydrolysate. Following administration in rats, <sup>14</sup>C was eliminated primarily in feces (89-97% of administered dose), exhaled volatile organic chemical (VOC) and CO<sub>2</sub> traps contained no radioactivity, and urine contained 0.2-0.4 %. In bile-duct-cannulated rats (100 mg/kg [<sup>14</sup>C]GB), 0.25% of dose was recovered in bile, and in urine, 0.5%. The percent of the dose absorbed was 0.9%, based on radioactivity in urine, bile, and carcass minus digestive tract contents. The highest level of radioactivity in tissues was in kidney; however renal recovery was low, with only 0.02-0.04% of the dose recovered in kidney. Repeated dosing indicated that <sup>14</sup>C accumulated in kidney, and was slowly removed following cessation of dosing, consistent with previous studies, in the absence of any functional or histopathological changes.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115107"},"PeriodicalIF":3.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effect of rutin on sciatic nerve injury in acrylamide-exposed rats and its mechanisms. 芦丁对丙烯酰胺暴露大鼠坐骨神经损伤的保护作用及其机制

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-11 DOI: 10.1016/j.fct.2024.115106

Suqiu Dong, Chunmei Zhang, Yunjue Wang, Shuping Liu, Junhua Yang, Lixia Li, Yuxin Ma, Jing Liu

Rutin (Rut) is a flavonoid with pharmacological activities such as anti-inflammatory and antioxidant. Acrylamide (ACR) is a toxic substance widely found in human life that can induce neurotoxicity. Some studies have confirmed that neurotoxicity caused by ACR induces myelin damage, which in turn causes neurological dysfunction. Therefore, we established a rutin intervention model to investigate the protective effect of Rut on ACR-induced sciatic nerve injury in rats and its mechanism. The results showed that superoxide dismutase (SOD) activity and glutathione (GSH) content increased and lactate dehydrogenase (LDH) activity decreased in the middle and high dose groups of Rut compared with the ACR group, and the expression of Myelin basic protein (MBP), Extracellular-regulated kinase 1/2(ERK1/2), Phosphorylated extracellular regulated kinase 1/2 (P-ERK1/2), and Nuclear factor E-2-associated factor (Nrf2) was promoted in the Rut-protected group, which suggests that Rutin has a protective effect on ACR-induced sciatic nerve injury and that the mechanism of Rutin's protective effect is related to activation of the ERK1/2 pathway and alleviation of oxidative stress injury.

芦丁（Rutin）是一种黄酮类化合物，具有抗炎和抗氧化等药理活性。丙烯酰胺（ACR）是一种广泛存在于人类生活中的有毒物质，可诱发神经中毒。有研究证实，丙烯酰胺引起的神经毒性会诱发髓鞘损伤，进而导致神经功能障碍。因此，我们建立了芦丁干预模型，研究芦丁对 ACR 引起的大鼠坐骨神经损伤的保护作用及其机制。结果表明，与 ACR 组相比，芦丁中、高剂量组大鼠超氧化物歧化酶（SOD）活性和谷胱甘肽（GSH）含量升高，乳酸脱氢酶（LDH）活性降低；髓鞘碱性蛋白（MBP）、细胞外调节激酶 1/2（ERK1/2）、磷酸化细胞外调节激酶 1/2（P-ERK1/2）和核因子 E-2-associated kinase 1/2（P-ERK1/2）的表达降低、这表明芦丁对 ACR 引起的坐骨神经损伤有保护作用，而芦丁的保护作用机制与激活 ERK1/2 通路和减轻氧化应激损伤有关。

{"title":"The protective effect of rutin on sciatic nerve injury in acrylamide-exposed rats and its mechanisms.","authors":"Suqiu Dong, Chunmei Zhang, Yunjue Wang, Shuping Liu, Junhua Yang, Lixia Li, Yuxin Ma, Jing Liu","doi":"10.1016/j.fct.2024.115106","DOIUrl":"https://doi.org/10.1016/j.fct.2024.115106","url":null,"abstract":"<p><p>Rutin (Rut) is a flavonoid with pharmacological activities such as anti-inflammatory and antioxidant. Acrylamide (ACR) is a toxic substance widely found in human life that can induce neurotoxicity. Some studies have confirmed that neurotoxicity caused by ACR induces myelin damage, which in turn causes neurological dysfunction. Therefore, we established a rutin intervention model to investigate the protective effect of Rut on ACR-induced sciatic nerve injury in rats and its mechanism. The results showed that superoxide dismutase (SOD) activity and glutathione (GSH) content increased and lactate dehydrogenase (LDH) activity decreased in the middle and high dose groups of Rut compared with the ACR group, and the expression of Myelin basic protein (MBP), Extracellular-regulated kinase 1/2(ERK1/2), Phosphorylated extracellular regulated kinase 1/2 (P-ERK1/2), and Nuclear factor E-2-associated factor (Nrf2) was promoted in the Rut-protected group, which suggests that Rutin has a protective effect on ACR-induced sciatic nerve injury and that the mechanism of Rutin's protective effect is related to activation of the ERK1/2 pathway and alleviation of oxidative stress injury.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115106"},"PeriodicalIF":3.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary exposure to high-intensity sweeteners by the Brazilian self-declared diabetic population and general Brazilian population 巴西自称糖尿病患者和巴西普通人群从膳食中摄入高甜度甜味剂的情况。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-09 DOI: 10.1016/j.fct.2024.115105

Crislei Gonçalves Pereira , Milton Cabral de Vasconcelos-Neto , Luiza Andrade Tomaz , Lucilene Rezende Anastácio , Flávia Beatriz Custódio

Due to an increasing use of high-intensity sweeteners in foods and potential health implications of high levels exposure, the intake of high-intensity sweeteners present in the diet of the Brazilian population and the self-declared diabetic population, based on national consumption data from the 2017–2018 Family Budget Survey (POF), was estimated. The occurrence of the high-intensity sweeteners was established by labeling foods obtained in physical stores and online, in two scenarios: average and maximum concentration. Food consumption data were derived for the self-declared diabetic Brazilian population and the Brazilian population for average consumers and consumers only, stratified by: sex, age, habitation, and regions from Brazil. For consumers only of the general Brazilian population, the intake of sodium cyclamate, steviol glycosides, and sucralose exceeded the Acceptable Daily Intake (ADI), mainly in adolescents (131.3%, 117.2, 123.0% of respective ADI). The estimated intake for the diabetic population was below ADI in all scenarios calculated. The most exposed diabetic population to sodium cyclamate and sucralose were female (69.6% and 59.4% of respective ADI) and the elderly (79.2% and 70.1% of respective ADI). The Brazilian population, mainly high consumers, was more exposed to high-intensity sweeteners than the self-declared diabetic population.

由于食品中高浓度甜味剂的使用日益增多，以及高浓度摄入对健康的潜在影响，我们根据 2017-2018 年家庭预算调查（POF）中的全国消费数据，估算了巴西人口和自称糖尿病患者人群饮食中高浓度甜味剂的摄入量。通过对在实体店和网上获得的食品进行标注，分两种情况确定了高强度甜味剂的存在情况：平均浓度和最高浓度。根据性别、年龄、居住地和巴西各地区进行分层，得出了自称为糖尿病患者的巴西人口以及普通消费者和仅消费者的巴西人口的食品消费数据。仅就巴西普通消费者而言，甜蜜素、甜菊糖苷和三氯蔗糖的摄入量均超过了每日允许摄入量（ADI），主要是青少年（分别为每日允许摄入量的 131.3%、117.2% 和 123.0%）。在所有计算方案中，糖尿病人群的估计摄入量均低于每日允许摄入量。接触甜蜜素和三氯蔗糖最多的糖尿病人群是女性（分别为每日允许摄入量的 69.6% 和 59.4%）和老年人（分别为每日允许摄入量的 79.2% 和 70.1%）。巴西人口（主要是高消费人群）比自我申报的糖尿病患者更容易接触高强度甜味剂。

{"title":"Dietary exposure to high-intensity sweeteners by the Brazilian self-declared diabetic population and general Brazilian population","authors":"Crislei Gonçalves Pereira , Milton Cabral de Vasconcelos-Neto , Luiza Andrade Tomaz , Lucilene Rezende Anastácio , Flávia Beatriz Custódio","doi":"10.1016/j.fct.2024.115105","DOIUrl":"10.1016/j.fct.2024.115105","url":null,"abstract":"<div><div>Due to an increasing use of high-intensity sweeteners in foods and potential health implications of high levels exposure, the intake of high-intensity sweeteners present in the diet of the Brazilian population and the self-declared diabetic population, based on national consumption data from the 2017–2018 Family Budget Survey (POF), was estimated. The occurrence of the high-intensity sweeteners was established by labeling foods obtained in physical stores and online, in two scenarios: average and maximum concentration. Food consumption data were derived for the self-declared diabetic Brazilian population and the Brazilian population for average consumers and consumers only, stratified by: sex, age, habitation, and regions from Brazil. For consumers only of the general Brazilian population, the intake of sodium cyclamate, steviol glycosides, and sucralose exceeded the Acceptable Daily Intake (ADI), mainly in adolescents (131.3%, 117.2, 123.0% of respective ADI). The estimated intake for the diabetic population was below ADI in all scenarios calculated. The most exposed diabetic population to sodium cyclamate and sucralose were female (69.6% and 59.4% of respective ADI) and the elderly (79.2% and 70.1% of respective ADI). The Brazilian population, mainly high consumers, was more exposed to high-intensity sweeteners than the self-declared diabetic population.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115105"},"PeriodicalIF":3.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the relationship between β-carotene intake from diet and supplements, smoking, and lung cancer risk 研究从饮食和补充剂中摄入的 β-胡萝卜素、吸烟与肺癌风险之间的关系。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-09 DOI: 10.1016/j.fct.2024.115104

Christopher A. Bates , Melissa J. Vincent , Amanda N. Buerger , Annette B. Santamaria , Andrew Maier , Maia Jack

β-carotene is a naturally occurring and safe dietary source of vitamin A that is associated with cancer risk reductions when consumed in typical dietary amounts. However, two clinical trials reported increased incidence of lung cancer and total mortality among heavy smokers taking β-carotene supplements (20 or 30 mg/day). Based on these findings, the Joint FAO/WHO Expert Committee on Food Additives withdrew Acceptable Daily Intake values for β-carotene (0–5 mg/kg bw). We evaluated relevant epidemiological and toxicological literature to assess the biological plausibility of this relationship and identified three mechanisms involving cellular proliferation signaling, a mode of action for cancer promotion. The overall weight of evidence consistently demonstrated typical dietary doses of β-carotene decreased cellular proliferation signaling via these mechanisms, even in the presence of smoke, while co-exposure to smoke and higher, supplemental doses increased cellular proliferation signaling through these same pathways. The production of excessive oxidative β-carotene metabolites via reactions with smoke constituents may be a key event underlying this relationship. Consistent with previous findings, our evaluation indicated consumption of up to 50 mg/day β-carotene does not present safety concerns for the non-smoking general population. Heavy smokers consuming less than 15 mg β-carotene/day are not expected to be at an increased risk of lung cancer.

β-胡萝卜素是一种天然、安全的维生素 A 膳食来源，按一般膳食量摄入可降低患癌风险。然而，有两项临床试验报告称，服用β-胡萝卜素补充剂（20 或 30 毫克/天）的重度吸烟者的肺癌发病率和总死亡率有所上升。基于这些研究结果，粮农组织/世卫组织食品添加剂联合专家委员会撤销了β-胡萝卜素（0-5 毫克/千克体重）的每日允许摄入量。我们评估了相关的流行病学和毒理学文献，以评估这种关系的生物学合理性，并确定了涉及细胞增殖信号转导的三种机制，这是一种促癌作用模式。总体证据一致表明，即使在有烟雾存在的情况下，典型膳食剂量的β-胡萝卜素也会通过这些机制减少细胞增殖信号，而同时暴露于烟雾和更高剂量的补充剂则会通过这些相同的途径增加细胞增殖信号。通过与烟雾成分的反应产生过多的β-胡萝卜素氧化代谢物可能是导致这种关系的关键因素。与之前的研究结果一致，我们的评估表明，对于不吸烟的普通人群来说，每天摄入多达 50 毫克的 β-胡萝卜素不会带来安全问题。每天摄入低于 15 毫克 β-胡萝卜素的重度吸烟者罹患肺癌的风险也不会增加。

{"title":"Investigating the relationship between β-carotene intake from diet and supplements, smoking, and lung cancer risk","authors":"Christopher A. Bates , Melissa J. Vincent , Amanda N. Buerger , Annette B. Santamaria , Andrew Maier , Maia Jack","doi":"10.1016/j.fct.2024.115104","DOIUrl":"10.1016/j.fct.2024.115104","url":null,"abstract":"<div><div>β-carotene is a naturally occurring and safe dietary source of vitamin A that is associated with cancer risk reductions when consumed in typical dietary amounts. However, two clinical trials reported increased incidence of lung cancer and total mortality among heavy smokers taking β-carotene supplements (20 or 30 mg/day). Based on these findings, the Joint FAO/WHO Expert Committee on Food Additives withdrew Acceptable Daily Intake values for β-carotene (0–5 mg/kg bw). We evaluated relevant epidemiological and toxicological literature to assess the biological plausibility of this relationship and identified three mechanisms involving cellular proliferation signaling, a mode of action for cancer promotion. The overall weight of evidence consistently demonstrated typical dietary doses of β-carotene decreased cellular proliferation signaling via these mechanisms, even in the presence of smoke, while co-exposure to smoke and higher, supplemental doses increased cellular proliferation signaling through these same pathways. The production of excessive oxidative β-carotene metabolites via reactions with smoke constituents may be a key event underlying this relationship. Consistent with previous findings, our evaluation indicated consumption of up to 50 mg/day β-carotene does not present safety concerns for the non-smoking general population. Heavy smokers consuming less than 15 mg β-carotene/day are not expected to be at an increased risk of lung cancer.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115104"},"PeriodicalIF":3.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organophosphate esters and their metabolites in Beijing total diets: Occurrence, time trend, and dietary exposure assessment 北京总膳食中的有机磷酸酯及其代谢物：发生率、时间趋势和膳食暴露评估。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-08 DOI: 10.1016/j.fct.2024.115103

Xia Cui , Shunying Yao , Haixian Jia , Xiaochen Ma , Sai Fan , Zhixiong Shi

Organophosphate esters (OPEs) and their metabolites (mOPEs) are emerging pollutants. In this study, 18 OPEs and 10 mOPEs were measured in the 6th and 7th Beijing total diet studies (TDSs), and the dietary intakes of these pollutants by Beijing adults were estimated to assess related health concerns. Most OPEs and mOPEs had high detecting frequencies in both TDSs, which indicated that various foods in Beijing have been universally contaminated with OPEs and mOPEs. Statistical analysis further confirmed that the levels of both ∑OPEs and ∑mOPEs in the 7th Beijing TDS were significantly higher than those in the 6th study, indicating heavier contamination of both OPEs and their metabolites with time. Along with increasing OPE/mOPE contamination level and food consumption values, significant increases of EDIs were observed during the two studies, with the average EDIs of ∑OPEs increasing from 5.07 to 24.1 ng/kg bw/day, and that of ∑mOPEs increasing from 2.07 to 7.23 ng/kg bw/day. Although a comparison between EDIs and reference of doses (RfDs) indicated that current intakes of OPEs could still not cause significant health risks, the sharply increasing contamination levels and EDIs suggested the necessity to continuously monitor these emerging food contaminants.

有机磷酸酯（OPEs）及其代谢物（mOPEs）是新出现的污染物。本研究在北京市第六次和第七次总膳食研究（TDS）中测定了 18 种 OPE 和 10 种 mOPE，并估算了北京市成年人从膳食中摄入这些污染物的情况，以评估相关的健康问题。在两次总膳食研究中，大多数 OPE 和 mOPE 的检出频率都很高，这表明北京的各种食物普遍受到 OPE 和 mOPE 的污染。统计分析进一步证实，北京市第 7 次总膳食研究中的∑OPEs 和∑mOPEs 含量明显高于第 6 次研究，表明随着时间的推移，OPEs 及其代谢物的污染程度越来越严重。随着 OPE/OPE 污染水平和食物消耗量的增加，两项研究中的 EDIs 也显著增加，∑OPEs 的平均 EDIs 从 5.07 纳克/千克体重/天增加到 24.1 纳克/千克体重/天，∑mOPEs 的平均 EDIs 从 2.07 纳克/千克体重/天增加到 7.23 纳克/千克体重/天。尽管将暴露限值与参考剂量（RfDs）进行比较后发现，目前摄入的 OPE 仍不会对健康造成重大危害，但污染水平和暴露限值的急剧上升表明，有必要对这些新出现的食品污染物进行持续监测。

{"title":"Organophosphate esters and their metabolites in Beijing total diets: Occurrence, time trend, and dietary exposure assessment","authors":"Xia Cui , Shunying Yao , Haixian Jia , Xiaochen Ma , Sai Fan , Zhixiong Shi","doi":"10.1016/j.fct.2024.115103","DOIUrl":"10.1016/j.fct.2024.115103","url":null,"abstract":"<div><div>Organophosphate esters (OPEs) and their metabolites (mOPEs) are emerging pollutants. In this study, 18 OPEs and 10 mOPEs were measured in the 6th and 7th Beijing total diet studies (TDSs), and the dietary intakes of these pollutants by Beijing adults were estimated to assess related health concerns. Most OPEs and mOPEs had high detecting frequencies in both TDSs, which indicated that various foods in Beijing have been universally contaminated with OPEs and mOPEs. Statistical analysis further confirmed that the levels of both ∑OPEs and ∑mOPEs in the 7th Beijing TDS were significantly higher than those in the 6th study, indicating heavier contamination of both OPEs and their metabolites with time. Along with increasing OPE/mOPE contamination level and food consumption values, significant increases of EDIs were observed during the two studies, with the average EDIs of ∑OPEs increasing from 5.07 to 24.1 ng/kg bw/day, and that of ∑mOPEs increasing from 2.07 to 7.23 ng/kg bw/day. Although a comparison between EDIs and reference of doses (RfDs) indicated that current intakes of OPEs could still not cause significant health risks, the sharply increasing contamination levels and EDIs suggested the necessity to continuously monitor these emerging food contaminants.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115103"},"PeriodicalIF":3.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of core genes and molecular prediction of drug targets for countering BPA-induced olfactory bulb neurotoxicity in male mice 鉴定核心基因并对药物靶点进行分子预测，以对抗双酚 A 诱导的雄性小鼠嗅球神经毒性。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-08 DOI: 10.1016/j.fct.2024.115098

Zhoujie Hao , Xin Guo , Li Li , Xuepei Lei , Zhongwei Tang , Mengyu Zhai , Jianqin Yuan

Bisphenol A (BPA) is ubiquitous in plastics, which can modify and improve the applicability and durability of plastics. Previous laboratory studies have shown that BPA can trigger cognitive impairment and depression. The olfactory bulb (OB) is significantly related to cognition and depression. However, there is a deficiency in information on BPA-induced OB neurotoxicity. Therefore, we analyzed the OB tissues of male mice at the transcriptional level after BPA poisoning at four different levels of concentration (0, 0.01, 0.1, and 1 μg/mL). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and weighted gene co-expression network analysis (WGCNA) were used to screen critical pathways and core genes. The result demonstrated that the PI3K-AKT signaling pathway might play a crucial role in the effects of BPA on the OB. In addition, two genes of the PI3K-AKT signaling pathway, the colony stimulating factor-1 receptor (Csf1r) and the toll-like receptor 2 (Tlr2), were screened by the protein-protein interaction networks. Furthermore, molecular docking identified ceftolozane as a potential drug candidate that could counteract BPA-related OB neurotoxicity. Conclusively, our results confirmed that BPA induced OB damage in male mice through the PI3K-AKT pathway and proposed that ceftolozane might reduce BPA-induced OB neurotoxicity.

双酚 A（BPA）在塑料中无处不在，它可以改变和提高塑料的适用性和耐用性。以往的实验室研究表明，双酚 A 可引发认知障碍和抑郁症。嗅球（OB）与认知和抑郁有很大关系。然而，有关双酚 A 诱导的嗅球神经毒性的信息却很缺乏。因此，我们分析了四种不同浓度（0、0.01、0.1 和 1 μg/mL）的双酚 A 中毒后雄性小鼠嗅球组织的转录水平。利用基因本体（GO）、京都基因组百科全书（KEGG）和加权基因共表达网络分析（WGCNA）筛选关键通路和核心基因。结果表明，PI3K-AKT 信号通路可能在双酚 A 对卵巢的影响中起关键作用。此外，蛋白质-蛋白质相互作用网络还筛选出了 PI3K-AKT 信号通路的两个基因，即集落刺激因子-1 受体（Csf1r）和收费样受体 2（Tlr2）。此外，分子对接发现头孢妥仑是一种潜在的候选药物，可以对抗与双酚A相关的转播车神经毒性。最终，我们的研究结果证实了双酚A通过PI3K-AKT通路诱导雄性小鼠OB损伤，并提出了头孢洛赞可能减轻双酚A诱导的OB神经毒性。

{"title":"Identification of core genes and molecular prediction of drug targets for countering BPA-induced olfactory bulb neurotoxicity in male mice","authors":"Zhoujie Hao , Xin Guo , Li Li , Xuepei Lei , Zhongwei Tang , Mengyu Zhai , Jianqin Yuan","doi":"10.1016/j.fct.2024.115098","DOIUrl":"10.1016/j.fct.2024.115098","url":null,"abstract":"<div><div>Bisphenol A (BPA) is ubiquitous in plastics, which can modify and improve the applicability and durability of plastics. Previous laboratory studies have shown that BPA can trigger cognitive impairment and depression. The olfactory bulb (OB) is significantly related to cognition and depression. However, there is a deficiency in information on BPA-induced OB neurotoxicity. Therefore, we analyzed the OB tissues of male mice at the transcriptional level after BPA poisoning at four different levels of concentration (0, 0.01, 0.1, and 1 μg/mL). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and weighted gene co-expression network analysis (WGCNA) were used to screen critical pathways and core genes. The result demonstrated that the PI3K-AKT signaling pathway might play a crucial role in the effects of BPA on the OB. In addition, two genes of the PI3K-AKT signaling pathway, the colony stimulating factor-1 receptor (Csf1r) and the toll-like receptor 2 (Tlr2), were screened by the protein-protein interaction networks. Furthermore, molecular docking identified ceftolozane as a potential drug candidate that could counteract BPA-related OB neurotoxicity. Conclusively, our results confirmed that BPA induced OB damage in male mice through the PI3K-AKT pathway and proposed that ceftolozane might reduce BPA-induced OB neurotoxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"194 ","pages":"Article 115098"},"PeriodicalIF":3.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 3-(cis-3-hexenyloxy)propanenitrile, CAS Registry Number 142653-61-0. RIFM 香料成分安全评估更新，3-(顺式-3-己烯氧基)丙腈，化学文摘社登记号 142653-61-0。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology

Pub Date : 2024-11-08 DOI: 10.1016/j.fct.2024.115096

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0