Extramedullary plasmacytoma is a rare and unusual complication of multiple myeloma (MM). Some sites for the extramedullary involvement of MM are the liver, spleen, lymph node, lung, and skin. Renal failure is another complication of MM due to myeloma kidney, uric acid nephropathy, hemoconcentration, or light chain disease. This study reported a case of MM with unusual presentation. She was a 61-year-old woman who was admitted to the internal ward due to severe renal failure, anemia, mild proteinuria, hypertension, thrombocytopenia, and soft tissue mass in both lungs in the spiral computed tomography (CT) scan. In the skull X-ray, there was not any lytic lesion. Further, plasma cells greater than 30% were observed in serum protein electrophoresis pick of gamma region and in the bone marrow aspiration, so the final diagnosis of the patients was MM with extramedullary plasmacytoma.
{"title":"A case of multiple myeloma with unusual presentation","authors":"A. Momeni, Rooholah Masoomi","doi":"10.34172/jsums.2023.626","DOIUrl":"https://doi.org/10.34172/jsums.2023.626","url":null,"abstract":"Extramedullary plasmacytoma is a rare and unusual complication of multiple myeloma (MM). Some sites for the extramedullary involvement of MM are the liver, spleen, lymph node, lung, and skin. Renal failure is another complication of MM due to myeloma kidney, uric acid nephropathy, hemoconcentration, or light chain disease. This study reported a case of MM with unusual presentation. She was a 61-year-old woman who was admitted to the internal ward due to severe renal failure, anemia, mild proteinuria, hypertension, thrombocytopenia, and soft tissue mass in both lungs in the spiral computed tomography (CT) scan. In the skull X-ray, there was not any lytic lesion. Further, plasma cells greater than 30% were observed in serum protein electrophoresis pick of gamma region and in the bone marrow aspiration, so the final diagnosis of the patients was MM with extramedullary plasmacytoma.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130979106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahnaz Jafari, H. Amini-khoei, Mohsen Cheshmpanam, R. Abdizadeh
Background and aims: Trichomoniasis is the most common non-viral sexually transmitted infection worldwide; although it is treated by a 5-nitroimidazole drug family such as metronidazole (MTZ) with numerous side effects, and in this regard, alternative new drugs are required. Therefore, this study examined the anti-Trichomoniasis effect of the hydroalcoholic extract of some traditional medicinal plants of Iran in vitro. Methods: In this experimental study, the hydroalcoholic extracts of medicinal plants were prepared by maceration at a stock concentration of 20 mg/mL in the saline solution and then used for in vitro anti-trichomonas experiments. Trichomonas vaginalis trophozoites were isolated from the patient and cultured in a Trypticase Yeast extract Iron-Serum-33 medium. In addition, 200 μL of the culture medium containing 5×104 trophozoites was diluted in plate wells, and 10 doses were separately added on trophozoites for each extract serially diluted between 0.12 and 16 mg/mL in triplicate. The plates were incubated for 48 hours at 37 ° C with 5% CO2 . The number of trophozoites was counted with a hemocytometer and Trypan blue staining. Finally, the half maximal inhibitory concentration (IC50) was calculated by probit analysis. Results: Among the tested plants, Eugenia caryophyllata, Camellia sinensis, and Terminalia chebula Retz showed the best anti-trichomonal activity with IC50 values of 1.21, 1.62, and 1.66 mg/mL, respectively. All tested extracts had more IC50 than MTZ (IC50 100 mg/mL), an antiprotozoal drug used as a positive control. Conclusion: According to the results of this study, E. caryophylata, C. sinensis and T. chebula Retz affected the growth of T. vaginalis. Thus, it is recommended that other studies use this plant for the treatment of trichomoniasis infection.
{"title":"A survey on the anti-Trichomonas vaginalis effect of the hydroalcoholic extract of various medicinal plants in vitro","authors":"Mahnaz Jafari, H. Amini-khoei, Mohsen Cheshmpanam, R. Abdizadeh","doi":"10.34172/jsums.2023.627","DOIUrl":"https://doi.org/10.34172/jsums.2023.627","url":null,"abstract":"Background and aims: Trichomoniasis is the most common non-viral sexually transmitted infection worldwide; although it is treated by a 5-nitroimidazole drug family such as metronidazole (MTZ) with numerous side effects, and in this regard, alternative new drugs are required. Therefore, this study examined the anti-Trichomoniasis effect of the hydroalcoholic extract of some traditional medicinal plants of Iran in vitro. Methods: In this experimental study, the hydroalcoholic extracts of medicinal plants were prepared by maceration at a stock concentration of 20 mg/mL in the saline solution and then used for in vitro anti-trichomonas experiments. Trichomonas vaginalis trophozoites were isolated from the patient and cultured in a Trypticase Yeast extract Iron-Serum-33 medium. In addition, 200 μL of the culture medium containing 5×104 trophozoites was diluted in plate wells, and 10 doses were separately added on trophozoites for each extract serially diluted between 0.12 and 16 mg/mL in triplicate. The plates were incubated for 48 hours at 37 ° C with 5% CO2 . The number of trophozoites was counted with a hemocytometer and Trypan blue staining. Finally, the half maximal inhibitory concentration (IC50) was calculated by probit analysis. Results: Among the tested plants, Eugenia caryophyllata, Camellia sinensis, and Terminalia chebula Retz showed the best anti-trichomonal activity with IC50 values of 1.21, 1.62, and 1.66 mg/mL, respectively. All tested extracts had more IC50 than MTZ (IC50 100 mg/mL), an antiprotozoal drug used as a positive control. Conclusion: According to the results of this study, E. caryophylata, C. sinensis and T. chebula Retz affected the growth of T. vaginalis. Thus, it is recommended that other studies use this plant for the treatment of trichomoniasis infection.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134228327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Managers play a vital and decisive role at the heart of organizations because they are considered the most important competitive advantage. Therefore, the aim of this study was to design a model for the specific competence model of the top managers of medical science universities in Iran. Methods: This applied, exploratory research was done using qualitative-inductive approach and the Strauss and Corbin basic theory method in the medical sciences universities of Iran from 2019 to 2022. The study population of this grounded theory-based qualitative research consisted of 17 individuals selected from among the chancellors and vice-chancellors of medical universities in Iran using purposive sampling. Results: The findings indicated 19 general categories in a model, including causal conditions (targeted organization, organizational indicators, competence factors, and individual factors), and central phenomenon (specific competence of senior managers). The other categories were underlying conditions (organizational characteristics, environmental field, external macro factors, and components of economic competence), and intervening conditions (personality traits, managerial intelligence, and management of changes and time). The remaining categories encompassed strategies (competence factors, education and talent management, managerial factors, standardization, and organizational factors) and consequences (organizational and national development in the field of health, medicine and welfare, society, and service management). Conclusion: The competencies of managers, as the key human resource, are extremely important for the success of the organization. The findings of this study demonstrated that the specific competencies of senior managers can be used as an indicator.
{"title":"Designing a specific competency model for the senior managers of medical sciences universities","authors":"M. Ganji, M. Dalvi, A. Shirvani","doi":"10.34172/jsums.2023.725","DOIUrl":"https://doi.org/10.34172/jsums.2023.725","url":null,"abstract":"Background and aims: Managers play a vital and decisive role at the heart of organizations because they are considered the most important competitive advantage. Therefore, the aim of this study was to design a model for the specific competence model of the top managers of medical science universities in Iran. Methods: This applied, exploratory research was done using qualitative-inductive approach and the Strauss and Corbin basic theory method in the medical sciences universities of Iran from 2019 to 2022. The study population of this grounded theory-based qualitative research consisted of 17 individuals selected from among the chancellors and vice-chancellors of medical universities in Iran using purposive sampling. Results: The findings indicated 19 general categories in a model, including causal conditions (targeted organization, organizational indicators, competence factors, and individual factors), and central phenomenon (specific competence of senior managers). The other categories were underlying conditions (organizational characteristics, environmental field, external macro factors, and components of economic competence), and intervening conditions (personality traits, managerial intelligence, and management of changes and time). The remaining categories encompassed strategies (competence factors, education and talent management, managerial factors, standardization, and organizational factors) and consequences (organizational and national development in the field of health, medicine and welfare, society, and service management). Conclusion: The competencies of managers, as the key human resource, are extremely important for the success of the organization. The findings of this study demonstrated that the specific competencies of senior managers can be used as an indicator.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129351760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Noise has many psychological effects. Although different studies have so far focused on various psychological effects, they have not evaluated communication skills and cognitive triad. Thus, this study was conducted to investigate the effect of noise exposure and noise annoyance on communication skills and cognitive triad. Methods: This cross-sectional study was conducted on 65 workers in 2021. The equivalent sound level (LeqA) was determined using dosimetry. Based on LeqA, noise exposure was divided into permissible and impermissible types. Noise annoyance was measured by the numerical rating scale recommended by ISO/TS 15666:2003. The Communication Skills Questionnaire and Cognitive Triad Inventory were used for data collection. Finally, the obtained data were analyzed by SPSS 24 using an independent samples t test and Spearman correlation test. Results: The mean (±standard deviation) age of workers was equal to 33.87 (±5.95) years. The results of the correlation test showed a positive and significant relationship between LeqA and noise annoyance (P<0.001, r=0.82). Based on the results of the independent samples t test, there was no significant difference in the scores of communication skills (P=0.11) and cognitive triad (P=0.93) in the two groups. Conclusion: In this study, a positive and significant relationship was found between noise exposure and noise annoyance. In addition, communication and cognitive skills were not significantly different in the two study groups. To accurately determine the relationships of variables, it is recommended to conduct similar studies with larger sample sizes while considering variables such as personality traits and social intelligence.
{"title":"Association between noise exposure and noise annoyance with communication skills and cognitive triad among mine workers, Iran","authors":"Rohollah Fallah Madvari, Reyhaneh Sefidkar, Hanie Dameshghi, Hamideh Bidel, F. Laal, Mahdi Jafari Nodoushan","doi":"10.34172/jsums.2023.722","DOIUrl":"https://doi.org/10.34172/jsums.2023.722","url":null,"abstract":"Background and aims: Noise has many psychological effects. Although different studies have so far focused on various psychological effects, they have not evaluated communication skills and cognitive triad. Thus, this study was conducted to investigate the effect of noise exposure and noise annoyance on communication skills and cognitive triad. Methods: This cross-sectional study was conducted on 65 workers in 2021. The equivalent sound level (LeqA) was determined using dosimetry. Based on LeqA, noise exposure was divided into permissible and impermissible types. Noise annoyance was measured by the numerical rating scale recommended by ISO/TS 15666:2003. The Communication Skills Questionnaire and Cognitive Triad Inventory were used for data collection. Finally, the obtained data were analyzed by SPSS 24 using an independent samples t test and Spearman correlation test. Results: The mean (±standard deviation) age of workers was equal to 33.87 (±5.95) years. The results of the correlation test showed a positive and significant relationship between LeqA and noise annoyance (P<0.001, r=0.82). Based on the results of the independent samples t test, there was no significant difference in the scores of communication skills (P=0.11) and cognitive triad (P=0.93) in the two groups. Conclusion: In this study, a positive and significant relationship was found between noise exposure and noise annoyance. In addition, communication and cognitive skills were not significantly different in the two study groups. To accurately determine the relationships of variables, it is recommended to conduct similar studies with larger sample sizes while considering variables such as personality traits and social intelligence.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130678444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soleiman Mohammadzadeh, Samad Hamidi, M. Rasouli, Bahar Sahadatmand, Bushra Zareie
Background and aims: Gestational diabetes has long-term adverse consequences for both the mother and child and seems to be a risk factor for attention deficit hyperactivity disorder (ADHD) in children. However, no research has been conducted in this regard in Iran. Methods: This was a case-control study. The sample consisted of 225 children who were referred to the general and psychiatric clinic of Besat Hospital in Sanandaj and were evaluated for a history of maternal diabetes in the fetal period. The diagnosis of ADHD in children was based on a structured clinical interview with Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL) by a psychiatrist and a short and revised form of Conners’ parent scale. The data were analyzed using Stata 14. Results: The results showed that 25.3% of the mothers of children with ADHD had gestational diabetes during pregnancy, and 17.3% were taking diabetes medication. However, the results revealed that there is no statistically significant relationship between the history of gestational diabetes and ADHD (P=0.427). Furthermore, the logistic regression results demonstrated that the place of residence (P<0.027, OR=8.351) increases the probability of suffering from ADHD in children, while the age of the mother during pregnancy (P<0.031, OR=0.907) decreases the probability of the child suffering from ADHD. Conclusion: Although cohort studies have associated gestational diabetes with an increased risk of ADHD in children, the results of this case-control study do not support this association.
{"title":"Association of maternal diabetes during pregnancy with attention deficit hyperactivity disorder in offspring in an Iranian population: A case-control study","authors":"Soleiman Mohammadzadeh, Samad Hamidi, M. Rasouli, Bahar Sahadatmand, Bushra Zareie","doi":"10.34172/jsums.2023.724","DOIUrl":"https://doi.org/10.34172/jsums.2023.724","url":null,"abstract":"Background and aims: Gestational diabetes has long-term adverse consequences for both the mother and child and seems to be a risk factor for attention deficit hyperactivity disorder (ADHD) in children. However, no research has been conducted in this regard in Iran. Methods: This was a case-control study. The sample consisted of 225 children who were referred to the general and psychiatric clinic of Besat Hospital in Sanandaj and were evaluated for a history of maternal diabetes in the fetal period. The diagnosis of ADHD in children was based on a structured clinical interview with Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL) by a psychiatrist and a short and revised form of Conners’ parent scale. The data were analyzed using Stata 14. Results: The results showed that 25.3% of the mothers of children with ADHD had gestational diabetes during pregnancy, and 17.3% were taking diabetes medication. However, the results revealed that there is no statistically significant relationship between the history of gestational diabetes and ADHD (P=0.427). Furthermore, the logistic regression results demonstrated that the place of residence (P<0.027, OR=8.351) increases the probability of suffering from ADHD in children, while the age of the mother during pregnancy (P<0.031, OR=0.907) decreases the probability of the child suffering from ADHD. Conclusion: Although cohort studies have associated gestational diabetes with an increased risk of ADHD in children, the results of this case-control study do not support this association.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116862095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Bagheri Sheykhangafshe, Arina Kiani, Alireza Alesadi Sani, Alireza Mohammadi Sangachin Doost, Vahid Savabi Niri
Background and aims: Coronavirus disease 2019 (COVID-19) has caused various psychosocial problems in many people worldwide. Patients with cancer are at higher risk of dying from COVID-19 because of their physical conditions. For this purpose, this research focused on reviewing studies on the quality of life (QoL) in cancer patients during the outbreak of COVID-19. Methods: In this study, several keywords, including cancer, quality of life, and COVID-19, in the abstract and title of articles published in 2020 (May) and 2022 (June) in reputable international scientific databases were searched in Google Scholar, ISI, Scopus, ScienceDirect, and PubMed databases. The PRISMA checklist was used to review the quality of the articles. Results: Based on the reviewed studies, it was found that cancer patients had high levels of depression, anxiety, insomnia, stress, and death anxiety during the COVID-19 pandemic. Home quarantine, fear of COVID-19, and limited access to a doctor and medication also reduced the QoL of cancer patients. Female gender, low income, old age, inappropriate lifestyle, lack of social support, low level of education, physical activity, marital status, and duration of illness were among the factors aggravating mental disorders in cancer. Conclusion: The findings indicated a decrease in the QoL in cancer patients. Given that it is unclear how long COVID-19 mutates as a pandemic, tele-mental health care is one of the solutions that can improve the QoL of cancer patients by providing timely services.
{"title":"Quality of life in cancer patients during the coronavirus 2019 pandemic: A systematic review study","authors":"F. Bagheri Sheykhangafshe, Arina Kiani, Alireza Alesadi Sani, Alireza Mohammadi Sangachin Doost, Vahid Savabi Niri","doi":"10.34172/jsums.2023.654","DOIUrl":"https://doi.org/10.34172/jsums.2023.654","url":null,"abstract":"Background and aims: Coronavirus disease 2019 (COVID-19) has caused various psychosocial problems in many people worldwide. Patients with cancer are at higher risk of dying from COVID-19 because of their physical conditions. For this purpose, this research focused on reviewing studies on the quality of life (QoL) in cancer patients during the outbreak of COVID-19. Methods: In this study, several keywords, including cancer, quality of life, and COVID-19, in the abstract and title of articles published in 2020 (May) and 2022 (June) in reputable international scientific databases were searched in Google Scholar, ISI, Scopus, ScienceDirect, and PubMed databases. The PRISMA checklist was used to review the quality of the articles. Results: Based on the reviewed studies, it was found that cancer patients had high levels of depression, anxiety, insomnia, stress, and death anxiety during the COVID-19 pandemic. Home quarantine, fear of COVID-19, and limited access to a doctor and medication also reduced the QoL of cancer patients. Female gender, low income, old age, inappropriate lifestyle, lack of social support, low level of education, physical activity, marital status, and duration of illness were among the factors aggravating mental disorders in cancer. Conclusion: The findings indicated a decrease in the QoL in cancer patients. Given that it is unclear how long COVID-19 mutates as a pandemic, tele-mental health care is one of the solutions that can improve the QoL of cancer patients by providing timely services.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132913059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ebrahim Khaki, Khosro Jalali Dehkordi, F. Taghian, S. Hoseini
Background and aims: The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a protective role against cardiovascular disease. Therefore, the aim of the present study was to investigate the effect of eight-week resistance training (RT) and the use of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in myocardial infarction (MI) models. Methods: In this experimental study, 25 rats were randomly divided into five groups including (1) control (C), (2) MI, (3) MI+RT, (4) MI+grape seed, and (5) MI+RT+grape seed. MI was induced by subcutaneous injection of isoprenaline (85 mg/kg). Grape seed nanoparticles were daily administered at a dose of 150 mg/kg for 8 weeks, and RT was performed 5 days a week. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P≤0.05). Results: MI models showed decreased expression of PGC-1α, PPARγ, and UCP-1 genes in cardiac tissue (P=0.001). However, RT combined with the use of grape seed nanoparticles had a significant effect on increasing the expression of PGC-1α (P=0.001), PPARγ (P=0.002), and UCP-1 (P=0.003) genes in the heart tissue of MI model mice. Conclusion: The consumption of grape seed nanoparticles along with RT has more effects on improving the expression of PGC-1α, PPARγ, and UCP-1 genes in MI than either alone. Therefore, the use of grape seed nanoparticles together with RT is recommended in case of MI.
{"title":"The effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in the myocardial infarction model","authors":"Ebrahim Khaki, Khosro Jalali Dehkordi, F. Taghian, S. Hoseini","doi":"10.34172/jsums.2022.31","DOIUrl":"https://doi.org/10.34172/jsums.2022.31","url":null,"abstract":"Background and aims: The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a protective role against cardiovascular disease. Therefore, the aim of the present study was to investigate the effect of eight-week resistance training (RT) and the use of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in myocardial infarction (MI) models. Methods: In this experimental study, 25 rats were randomly divided into five groups including (1) control (C), (2) MI, (3) MI+RT, (4) MI+grape seed, and (5) MI+RT+grape seed. MI was induced by subcutaneous injection of isoprenaline (85 mg/kg). Grape seed nanoparticles were daily administered at a dose of 150 mg/kg for 8 weeks, and RT was performed 5 days a week. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P≤0.05). Results: MI models showed decreased expression of PGC-1α, PPARγ, and UCP-1 genes in cardiac tissue (P=0.001). However, RT combined with the use of grape seed nanoparticles had a significant effect on increasing the expression of PGC-1α (P=0.001), PPARγ (P=0.002), and UCP-1 (P=0.003) genes in the heart tissue of MI model mice. Conclusion: The consumption of grape seed nanoparticles along with RT has more effects on improving the expression of PGC-1α, PPARγ, and UCP-1 genes in MI than either alone. Therefore, the use of grape seed nanoparticles together with RT is recommended in case of MI.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122526999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Asadi-Samani, Marziyeh Soltani, Fereidoun Rahmani, S. Kheiri, M. Moradi
Background and aims: Due to the different levels of exposure of different people to the coronavirus and different levels of immune response among them, this study was designed to investigate the humoral immune responses against the coronavirus disease 2019 (COVID-19) in healthcare staff in hospitals and medical centers admitting COVID-19 patients. Methods: In this descriptive-analytical study, which was performed by call-out, the serum levels of IgM and IgG antibodies in 492 staff of hospitals and medical centers were evaluated using ELISA. Then, factors influencing the immune response of participants were determined. Results: IgG positivity was 11.6% among participants of this study, 19.2% of the staff had a positive polymerase chain reaction (PCR) test, and the IgG positivity rate among them was only 16%. There was no significant relationship between body mass index, underlying diseases, diabetes, immune system-related diseases, herpes simplex virus, workplace, blood type, education level, symptoms, and IgG response (P>0.05). Further, the rate of IgG positivity in healthcare staff indicated a significant relationship only with gender (P=0.005), history of hospitalization (P=0.002) due to COVID-19 and position (P=0.008). Conclusion: This study found that the prevalence of humoral immune response in healthcare staff was lower than the prevalence of the disease based on molecular tests. Based on the results of the present study, it is possible to provide an accurate estimate of the level of involvement and predisposition of healthcare staff in hospital wards and medical centers and to use this information for disease management and control.
{"title":"Evaluation of Humoral immune responses against coronavirus in healthcare staff in hospitals and medical centers of Shahrekord University of Medical Sciences, Iran","authors":"M. Asadi-Samani, Marziyeh Soltani, Fereidoun Rahmani, S. Kheiri, M. Moradi","doi":"10.34172/jsums.2022.27","DOIUrl":"https://doi.org/10.34172/jsums.2022.27","url":null,"abstract":"Background and aims: Due to the different levels of exposure of different people to the coronavirus and different levels of immune response among them, this study was designed to investigate the humoral immune responses against the coronavirus disease 2019 (COVID-19) in healthcare staff in hospitals and medical centers admitting COVID-19 patients. Methods: In this descriptive-analytical study, which was performed by call-out, the serum levels of IgM and IgG antibodies in 492 staff of hospitals and medical centers were evaluated using ELISA. Then, factors influencing the immune response of participants were determined. Results: IgG positivity was 11.6% among participants of this study, 19.2% of the staff had a positive polymerase chain reaction (PCR) test, and the IgG positivity rate among them was only 16%. There was no significant relationship between body mass index, underlying diseases, diabetes, immune system-related diseases, herpes simplex virus, workplace, blood type, education level, symptoms, and IgG response (P>0.05). Further, the rate of IgG positivity in healthcare staff indicated a significant relationship only with gender (P=0.005), history of hospitalization (P=0.002) due to COVID-19 and position (P=0.008). Conclusion: This study found that the prevalence of humoral immune response in healthcare staff was lower than the prevalence of the disease based on molecular tests. Based on the results of the present study, it is possible to provide an accurate estimate of the level of involvement and predisposition of healthcare staff in hospital wards and medical centers and to use this information for disease management and control.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115373029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elnaz Deldadeh Mehraban, A. Farhangi, S. Abolghasemi
Background and aims: Post-traumatic growth refers to the positive psychological changes experienced after an incident. Coronavirus disease 2019 (COVID-19) is seen as a traumatic incident that impacts many aspects of a person's life. The present study aimed to investigate the association between perceived social support and mental health with the post-traumatic growth model through the mediating role of coping strategies in COVID-19 recovered patients. Methods: This study was conducted using a path analysis method from the correlation matrix. The research population included all COVID-19 recovered patients in Golestan Province. Using the convenience sampling method, 300 patients who recovered from COVID-19 were selected. The research instruments included the Post-Traumatic Growth Inventory, the General Health Questionnaire, the Multidimensional Scale of Perceived Social Support, and the Ways of Coping Questionnaire. The data was analyzed through structural equation modeling (SEM) using SPSS and AMOS software version 25. Results: The findings revealed that the suggested model fit the data. The relationship between post-traumatic growth, perceived social support, and mental health with problem-focused coping strategies were positive and significant (P<0.01). The relations between mental health and perceived social support with post-traumatic growth were positive and significant. Post-traumatic growth and perceived social support had a negative and significant relationship with emotion-focused strategies (P<0.01). Furthermore, the relationship between mental health and emotion-focused strategies was not significant. Conclusion: Mental health, perceived social support, and problem-focused strategies play an essential role in COVID-19 patients' post-traumatic growth. As a result, they might be helpful in minimizing the psychological impact of COVID-19.
{"title":"The relationship between mental health and perceived social support with the post traumatic growth model through the mediating role of coping strategies in COVID-19 recovered patients","authors":"Elnaz Deldadeh Mehraban, A. Farhangi, S. Abolghasemi","doi":"10.34172/jsums.2022.30","DOIUrl":"https://doi.org/10.34172/jsums.2022.30","url":null,"abstract":"Background and aims: Post-traumatic growth refers to the positive psychological changes experienced after an incident. Coronavirus disease 2019 (COVID-19) is seen as a traumatic incident that impacts many aspects of a person's life. The present study aimed to investigate the association between perceived social support and mental health with the post-traumatic growth model through the mediating role of coping strategies in COVID-19 recovered patients. Methods: This study was conducted using a path analysis method from the correlation matrix. The research population included all COVID-19 recovered patients in Golestan Province. Using the convenience sampling method, 300 patients who recovered from COVID-19 were selected. The research instruments included the Post-Traumatic Growth Inventory, the General Health Questionnaire, the Multidimensional Scale of Perceived Social Support, and the Ways of Coping Questionnaire. The data was analyzed through structural equation modeling (SEM) using SPSS and AMOS software version 25. Results: The findings revealed that the suggested model fit the data. The relationship between post-traumatic growth, perceived social support, and mental health with problem-focused coping strategies were positive and significant (P<0.01). The relations between mental health and perceived social support with post-traumatic growth were positive and significant. Post-traumatic growth and perceived social support had a negative and significant relationship with emotion-focused strategies (P<0.01). Furthermore, the relationship between mental health and emotion-focused strategies was not significant. Conclusion: Mental health, perceived social support, and problem-focused strategies play an essential role in COVID-19 patients' post-traumatic growth. As a result, they might be helpful in minimizing the psychological impact of COVID-19.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115415852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editor, According to the evidence, neuroimmune activation plays a crucial role in neurological disorders such as stroke and Parkinson’s disease (1). Clarifying immunity is the initial step in properly investigating neuroimmune activation (2). The immune system is a complex information processing system that protects the body against infectious diseases and allergens and maintains homeostasis (3). Two types of immunity exist: innate and adaptive. Adaptive immunity is specific and consists of antibodies and cells, whereas innate immunity is non-specific, has a rapid response, and includes physical agents and chemical components such as cytokines and inflammatory cells (T and B lymphocytes). Typically, innate and adaptive immune systems work in tandem to invade pathogens (4). In the past, the central nervous system (CNS) was commonly viewed as an immunologically unique organ in which the immune system could not exist under normal circumstances. Neuroimmune signaling has recently been identified as one of the most important mechanisms underlying memory, emotion, and cognition. The CNS is involved in immunological processes under physiological and pathological conditions, and the brain is a highly immunologically active organ due to innate immune cells residing in the CNS and peripheral immune cells invading the brain (5). Neuroinflammation is currently recognized as a significant factor in almost all neurodegenerative disorders. Microglia are the first line of defense in the brain against pathogens, traumatic brain injury (TBI), and other stresses, and their role in neuroinflammation is crucial (6). Neuroimmune responses in the brain are typically the results of innate immunity. In contrast, the adaptive immune system, such as T-cells, is required for optimal neural activity, memory, and cytokine release in the brain during illness (7). Nonetheless, illness and trauma are evidenced as stimuli that activate the neuroimmune systems. In the homeostatic baseline, neuroimmune signaling interacts with neurons and regulates the neural function and synaptic plasticity (8). During neuroimmune activation, pathological conditions activate endothelial cells, microglia, and astrocytes, which produce cytokines and chemokines (9). As a result, the immune mechanism operates without immune cells entering damaged tissue (10). CNS diseases, such as neurodegenerative disorders, are linked to glial activation, cell migration, antigen expression, and cytokine release. Briefly, neuroimmune activation occurs when microglia are activated or immune molecules, particularly cytokines and chemokines, are overexpressed (11). Given the role of the immune system in neurodegenerative diseases, targeting immune reactions within the brain may hold great promise as a treatment for these conditions. Consequently, biomaterials that interact with the immune components of the innate immune system, including cytokines, chemokines, complement, neuroglia cells, and astrocytes, have the p
{"title":"The role of biomaterials in degenerative diseases","authors":"Seyed-Amirabbas Ahadiat, Z. Hosseinian","doi":"10.34172/jsums.2022.25","DOIUrl":"https://doi.org/10.34172/jsums.2022.25","url":null,"abstract":"Dear Editor, According to the evidence, neuroimmune activation plays a crucial role in neurological disorders such as stroke and Parkinson’s disease (1). Clarifying immunity is the initial step in properly investigating neuroimmune activation (2). The immune system is a complex information processing system that protects the body against infectious diseases and allergens and maintains homeostasis (3). Two types of immunity exist: innate and adaptive. Adaptive immunity is specific and consists of antibodies and cells, whereas innate immunity is non-specific, has a rapid response, and includes physical agents and chemical components such as cytokines and inflammatory cells (T and B lymphocytes). Typically, innate and adaptive immune systems work in tandem to invade pathogens (4). In the past, the central nervous system (CNS) was commonly viewed as an immunologically unique organ in which the immune system could not exist under normal circumstances. Neuroimmune signaling has recently been identified as one of the most important mechanisms underlying memory, emotion, and cognition. The CNS is involved in immunological processes under physiological and pathological conditions, and the brain is a highly immunologically active organ due to innate immune cells residing in the CNS and peripheral immune cells invading the brain (5). Neuroinflammation is currently recognized as a significant factor in almost all neurodegenerative disorders. Microglia are the first line of defense in the brain against pathogens, traumatic brain injury (TBI), and other stresses, and their role in neuroinflammation is crucial (6). Neuroimmune responses in the brain are typically the results of innate immunity. In contrast, the adaptive immune system, such as T-cells, is required for optimal neural activity, memory, and cytokine release in the brain during illness (7). Nonetheless, illness and trauma are evidenced as stimuli that activate the neuroimmune systems. In the homeostatic baseline, neuroimmune signaling interacts with neurons and regulates the neural function and synaptic plasticity (8). During neuroimmune activation, pathological conditions activate endothelial cells, microglia, and astrocytes, which produce cytokines and chemokines (9). As a result, the immune mechanism operates without immune cells entering damaged tissue (10). CNS diseases, such as neurodegenerative disorders, are linked to glial activation, cell migration, antigen expression, and cytokine release. Briefly, neuroimmune activation occurs when microglia are activated or immune molecules, particularly cytokines and chemokines, are overexpressed (11). Given the role of the immune system in neurodegenerative diseases, targeting immune reactions within the brain may hold great promise as a treatment for these conditions. Consequently, biomaterials that interact with the immune components of the innate immune system, including cytokines, chemokines, complement, neuroglia cells, and astrocytes, have the p","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"10 18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125762139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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