Najmeh Dezhkam, Mohammad Reza Zarbakhsh Bahri, Ali Khaneh Keshi
Background and aims: Cognitive emotion regulation strategies enhance students’ ability to handle emotional and stressful situations and lead to resilient behavior and suitable behavioral performance. The present study aimed to investigate the association of addiction tendency with distress tolerance, self-differentiation, and emotion regulation difficulties mediated by resilience in university students. Methods: This was a descriptive-correlational study using structural equation modeling (SEM). Cluster sampling was used to enroll 314 individuals among all students at the Islamic Azad University of Tehran in the academic year 2020-2021. The research instruments included the Shorter PROMIS Questionnaire (SPQ), the Distress Tolerance Scale-Short Form (DTS-SF), the Self-Other Differentiation Scale (SODS), the Emotion Regulation Questionnaire (ERQ), and Connor-Davidson Resilience Scale (CD-RISC). Data were analyzed by the SEM method using SPSS-26 and SmartPLS. Results: The results showed that distress tolerance (β=0.25, P<0.001) and emotion regulation difficulties (β=0.35, P<0.001) had a significant direct association with resilience. In addition, distress tolerance (β=0.14, P<0.001), self-differentiation (β=0.25, P<0.001), emotion regulation difficulties (β=0.27, P<0.001), and resilience (β=0.22, P<0.001) had a significant direct relationship with addictive tendencies. Moreover, resilience mediated the association of distress tolerance and emotion regulation difficulties with addictive tendencies in college students. Conclusion: The proposed model had the desired fitting based on the results. It is a great step toward understanding factors associated with addiction tendencies in university students. Furthermore, it is an appropriate model, according to which various programs can be developed and designed to prevent addiction tendencies among university students.
{"title":"Association of addiction tendency with distress tolerance, self-differentiation, and emotion regulation difficulties mediated by resilience in university students","authors":"Najmeh Dezhkam, Mohammad Reza Zarbakhsh Bahri, Ali Khaneh Keshi","doi":"10.34172/jsums.2023.760","DOIUrl":"https://doi.org/10.34172/jsums.2023.760","url":null,"abstract":"Background and aims: Cognitive emotion regulation strategies enhance students’ ability to handle emotional and stressful situations and lead to resilient behavior and suitable behavioral performance. The present study aimed to investigate the association of addiction tendency with distress tolerance, self-differentiation, and emotion regulation difficulties mediated by resilience in university students. Methods: This was a descriptive-correlational study using structural equation modeling (SEM). Cluster sampling was used to enroll 314 individuals among all students at the Islamic Azad University of Tehran in the academic year 2020-2021. The research instruments included the Shorter PROMIS Questionnaire (SPQ), the Distress Tolerance Scale-Short Form (DTS-SF), the Self-Other Differentiation Scale (SODS), the Emotion Regulation Questionnaire (ERQ), and Connor-Davidson Resilience Scale (CD-RISC). Data were analyzed by the SEM method using SPSS-26 and SmartPLS. Results: The results showed that distress tolerance (β=0.25, P<0.001) and emotion regulation difficulties (β=0.35, P<0.001) had a significant direct association with resilience. In addition, distress tolerance (β=0.14, P<0.001), self-differentiation (β=0.25, P<0.001), emotion regulation difficulties (β=0.27, P<0.001), and resilience (β=0.22, P<0.001) had a significant direct relationship with addictive tendencies. Moreover, resilience mediated the association of distress tolerance and emotion regulation difficulties with addictive tendencies in college students. Conclusion: The proposed model had the desired fitting based on the results. It is a great step toward understanding factors associated with addiction tendencies in university students. Furthermore, it is an appropriate model, according to which various programs can be developed and designed to prevent addiction tendencies among university students.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"416 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131821850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine (Phe) metabolism. Mutations in the phenylalanine hydroxylase (PAH) gene are the main reason for the incidence of PKU. To date, more than 1180 variants have been detected in the PAH gene. Given that the distribution pattern of mutations in the PAH gene is specific to each population, the present study was conducted to detect exon 4 mutations and adjacent flanking regions of the PAH gene in northern Iran. Methods: This is a descriptive cross-sectional study, in which 24 unrelated PKU patients in Taleghani Hospital in Gorgan were enrolled for a one-year period. After extraction of genomic DNA from leukocytes, identification of exon 4 mutations and adjacent flanking regions was performed using polymerase chain reaction (PCR) and sequencing techniques. Results: In this study, IVS4+1G>A mutation was detected in one allele (2.08%) among 48 alleles. Moreover, IVS4+47C>T and IVS3-22C>T polymorphisms were observed in 12 alleles (25%) and eight alleles (16.7%), respectively. Conclusion: In the present study, IVS4+1G>A mutation was only found in 2% of chromosomes. Hence, different mutations are responsible for PKU disease in the north of Iran, and further studies are recommended to identify all mutations in the PAH gene in the region.
{"title":"Detection of IVS4+1G>A mutation in phenylalanine hydroxylase gene in North of Iran using PCR-sequencing","authors":"Maryam Amini Chelak, Zeinab Khazaei Koohpar","doi":"10.34172/jsums.2023.759","DOIUrl":"https://doi.org/10.34172/jsums.2023.759","url":null,"abstract":"Background and aims: Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine (Phe) metabolism. Mutations in the phenylalanine hydroxylase (PAH) gene are the main reason for the incidence of PKU. To date, more than 1180 variants have been detected in the PAH gene. Given that the distribution pattern of mutations in the PAH gene is specific to each population, the present study was conducted to detect exon 4 mutations and adjacent flanking regions of the PAH gene in northern Iran. Methods: This is a descriptive cross-sectional study, in which 24 unrelated PKU patients in Taleghani Hospital in Gorgan were enrolled for a one-year period. After extraction of genomic DNA from leukocytes, identification of exon 4 mutations and adjacent flanking regions was performed using polymerase chain reaction (PCR) and sequencing techniques. Results: In this study, IVS4+1G>A mutation was detected in one allele (2.08%) among 48 alleles. Moreover, IVS4+47C>T and IVS3-22C>T polymorphisms were observed in 12 alleles (25%) and eight alleles (16.7%), respectively. Conclusion: In the present study, IVS4+1G>A mutation was only found in 2% of chromosomes. Hence, different mutations are responsible for PKU disease in the north of Iran, and further studies are recommended to identify all mutations in the PAH gene in the region.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127764153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: The aim of this study was to investigate the combined effect of interval training and resveratrol consumption on the regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes. Methods: Frothy-two male Wistar rats were randomly divided into healthy control, diabetic, saline diabetic, resveratrol supplement, intermittent exercise, and resveratrol+intermittent exercise groups. The interval training program consisted of 8 weeks of training with an intensity of 50%-70% of the maximum oxygen consumption. Resveratrol was injected in two training groups with resveratrol supplement and resveratrol+supplement at a dose of 20 mg. Results: The concentrations of caspase-3 and BAX in diabetic saline and diabetic groups were significantly higher than in control groups (P=0.001). On the other hand, Bcl-2 (B-cell lymphoma 2) levels in diabetic saline and diabetic were significantly lower than in the control groups (P=0.001). The concentration of the BAX/Bcl-2 ratio in diabetic and diabetic saline was significantly higher compared to control groups (P=0.001) The effect of interval training, administration of resveratrol alone, or especially with interval training caused a significant decrease in the concentration of BAX and caspase-3 (P=0.001), a significant increase in the mean Bcl-2 concentration (P=0.001), and a significant decrease in the mean BAX/Bcl-2 ratio (P=0.001) in male rats with diabetes compared with the diabetic and diabetic groups. Conclusion: The combined effect of eight-week resveratrol supplementation and interval training decreased apoptosis markers, while it increased the concentration of Bcl-2 in male rats with type 2 diabetes.
{"title":"The combined effect of eight-week resveratrol supplementation and interval training on some regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes","authors":"Hamidreza Negarestani, Masome Nobahar, A. Mehri","doi":"10.34172/jsums.2023.746","DOIUrl":"https://doi.org/10.34172/jsums.2023.746","url":null,"abstract":"Background and aims: The aim of this study was to investigate the combined effect of interval training and resveratrol consumption on the regulatory and executive factors of hepatocyte apoptosis in male rats with diabetes. Methods: Frothy-two male Wistar rats were randomly divided into healthy control, diabetic, saline diabetic, resveratrol supplement, intermittent exercise, and resveratrol+intermittent exercise groups. The interval training program consisted of 8 weeks of training with an intensity of 50%-70% of the maximum oxygen consumption. Resveratrol was injected in two training groups with resveratrol supplement and resveratrol+supplement at a dose of 20 mg. Results: The concentrations of caspase-3 and BAX in diabetic saline and diabetic groups were significantly higher than in control groups (P=0.001). On the other hand, Bcl-2 (B-cell lymphoma 2) levels in diabetic saline and diabetic were significantly lower than in the control groups (P=0.001). The concentration of the BAX/Bcl-2 ratio in diabetic and diabetic saline was significantly higher compared to control groups (P=0.001) The effect of interval training, administration of resveratrol alone, or especially with interval training caused a significant decrease in the concentration of BAX and caspase-3 (P=0.001), a significant increase in the mean Bcl-2 concentration (P=0.001), and a significant decrease in the mean BAX/Bcl-2 ratio (P=0.001) in male rats with diabetes compared with the diabetic and diabetic groups. Conclusion: The combined effect of eight-week resveratrol supplementation and interval training decreased apoptosis markers, while it increased the concentration of Bcl-2 in male rats with type 2 diabetes.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128521089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: One of the most common causes of liver disease is non-alcoholic fatty liver disease (NAFLD), and its prevalence along with serious clinical problem is a growing. No studies have been conducted on the effect of calorie restriction (CR) and aerobic exercise (AE) on nuclear factor erythroid-related factor 2 (Nrf2) in rats with NAFLD. The present study aimed to assess the effects of 12 weeks of CR and AE on Nrf2 protein expression in rats with NAFLD. Methods: A total of 40 rats participated in this study, and 32 of them developed NAFLD by feeding fatty food (34% fat, 19% protein, and 47% carbohydrates) for eight weeks. Rats were classified into five groups: sham, control, CR, AE, and calorie restriction-aerobic exercise (CA). First, 60% of the daily diet was given to the CR and CA groups. AE was done for 12 weeks, five sessions per week on a treadmill for rats. Oil red, hematoxylin-eosin (H & E) staining, and protein expression levels in the groups were evaluated. To analyze the data, one-way ANOVA was used at a significance level of P<0.05. Results: The results showed a significant difference between the liver fat of the control group and other groups (RC: P=0.001, AE: P=0.001, RA: P=0.001). In healing liver damage, the control group was significantly different from the CA group (P=0.002). Regarding the Nrf2 protein expression, the CA group had significantly higher expression than the CR group (P=0.028), however there was no significant difference between the CA and AE groups (P=0.44). Conclusion: The findings revealed that AE through CR can cause recovery for NAFLD.
{"title":"The effect of 12 weeks of aerobic exercise and caloric restriction on Nrf2 protein expression in non-alcoholic fatty liver disease in rats","authors":"Farzaneh Yadegari, Farhad Rahmani Nia","doi":"10.34172/jsums.2023.744","DOIUrl":"https://doi.org/10.34172/jsums.2023.744","url":null,"abstract":"Background and aims: One of the most common causes of liver disease is non-alcoholic fatty liver disease (NAFLD), and its prevalence along with serious clinical problem is a growing. No studies have been conducted on the effect of calorie restriction (CR) and aerobic exercise (AE) on nuclear factor erythroid-related factor 2 (Nrf2) in rats with NAFLD. The present study aimed to assess the effects of 12 weeks of CR and AE on Nrf2 protein expression in rats with NAFLD. Methods: A total of 40 rats participated in this study, and 32 of them developed NAFLD by feeding fatty food (34% fat, 19% protein, and 47% carbohydrates) for eight weeks. Rats were classified into five groups: sham, control, CR, AE, and calorie restriction-aerobic exercise (CA). First, 60% of the daily diet was given to the CR and CA groups. AE was done for 12 weeks, five sessions per week on a treadmill for rats. Oil red, hematoxylin-eosin (H & E) staining, and protein expression levels in the groups were evaluated. To analyze the data, one-way ANOVA was used at a significance level of P<0.05. Results: The results showed a significant difference between the liver fat of the control group and other groups (RC: P=0.001, AE: P=0.001, RA: P=0.001). In healing liver damage, the control group was significantly different from the CA group (P=0.002). Regarding the Nrf2 protein expression, the CA group had significantly higher expression than the CR group (P=0.028), however there was no significant difference between the CA and AE groups (P=0.44). Conclusion: The findings revealed that AE through CR can cause recovery for NAFLD.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122602920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Significant biological changes occur during growth spurts, particularly at pre/post-maturity stages. It seems that such changes are associated with neuromuscular patterns, with considerable differences in functional movements performed by growing boys and girls through the process of maturation. The purpose of the study was to investigate the association between school-aged children’s maturity and their ability to move efficiently. Methods: A cross-sectional observational study was conducted on 700 healthy school-aged children, aged 8–17 years, who were randomly selected and divided into ten groups of 35 girls and ten groups of 35 boys. We used maturity offset prediction equations and the Fusionetics tests to evaluate the maturity and movement efficiency, respectively. Furthermore, the relationship between maturity and Fusionetics scores was examined using Spearman’s rank correlation coefficient (P≤0.05). Results: The findings of the study demonstrated that there is a moderate association between maturity and Fusionetics scores (boys r=0.34, P=0.001 and girls r=0.44, P=0.001). The results also estimated that more mature children gain better Fusionetics scores (r=0.45; P=0.001). Conclusion: It seems that maturity is correlated with movement efficiency, and more mature children can obtain better Fusionetics scores. Future research is needed to track maturity-related variations in functional movement scores in adolescence.
{"title":"Is there any association between school-aged children’s maturity and movement efficiency?","authors":"Sajad Bagherian, Khodayar Ghasempoor, M. Alizadeh","doi":"10.34172/jsums.2023.657","DOIUrl":"https://doi.org/10.34172/jsums.2023.657","url":null,"abstract":"Background and aims: Significant biological changes occur during growth spurts, particularly at pre/post-maturity stages. It seems that such changes are associated with neuromuscular patterns, with considerable differences in functional movements performed by growing boys and girls through the process of maturation. The purpose of the study was to investigate the association between school-aged children’s maturity and their ability to move efficiently. Methods: A cross-sectional observational study was conducted on 700 healthy school-aged children, aged 8–17 years, who were randomly selected and divided into ten groups of 35 girls and ten groups of 35 boys. We used maturity offset prediction equations and the Fusionetics tests to evaluate the maturity and movement efficiency, respectively. Furthermore, the relationship between maturity and Fusionetics scores was examined using Spearman’s rank correlation coefficient (P≤0.05). Results: The findings of the study demonstrated that there is a moderate association between maturity and Fusionetics scores (boys r=0.34, P=0.001 and girls r=0.44, P=0.001). The results also estimated that more mature children gain better Fusionetics scores (r=0.45; P=0.001). Conclusion: It seems that maturity is correlated with movement efficiency, and more mature children can obtain better Fusionetics scores. Future research is needed to track maturity-related variations in functional movement scores in adolescence.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126756968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatic subcapsular hematoma is a rare but potentially life-threatening complication that is caused by preeclampsia and hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome, which may be manifest with nonspecific signs and symptoms. The present case was a 36-year-old woman with a secondary subcapsular liver hematoma as a rare complication of HELLP syndrome. The patient complained of nausea, vomiting, pain in the right upper quadrant of the abdomen, epigastric pain, and severe pain in the right shoulder. On the fourth day after delivery, a computed tomography (CT) scan was performed on the patient, showing a large subcapsular hematoma around the liver. Six weeks after delivery, the follow-up ultrasound exhibited no residual hematoma or free peritoneal fluid, and the patient’s blood pressure was controlled without taking medication.
{"title":"The conservative management of a large hepatic subcapsular hematoma in a pregnant woman with preeclampsia: A case report","authors":"S. Khanjani, S. Shabanian","doi":"10.34172/jsums.2023.563","DOIUrl":"https://doi.org/10.34172/jsums.2023.563","url":null,"abstract":"Hepatic subcapsular hematoma is a rare but potentially life-threatening complication that is caused by preeclampsia and hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome, which may be manifest with nonspecific signs and symptoms. The present case was a 36-year-old woman with a secondary subcapsular liver hematoma as a rare complication of HELLP syndrome. The patient complained of nausea, vomiting, pain in the right upper quadrant of the abdomen, epigastric pain, and severe pain in the right shoulder. On the fourth day after delivery, a computed tomography (CT) scan was performed on the patient, showing a large subcapsular hematoma around the liver. Six weeks after delivery, the follow-up ultrasound exhibited no residual hematoma or free peritoneal fluid, and the patient’s blood pressure was controlled without taking medication.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"363 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116771521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moving toward being internationally scooped","authors":"E. Heidarian, E. Raeisi","doi":"10.34172/jsums.2023.784","DOIUrl":"https://doi.org/10.34172/jsums.2023.784","url":null,"abstract":"","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124903147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Behrouz Baghaiee, Nasibeh Dolatabadi Farahani, Linda S Pescatello, Elshan Davaran Hagh, K. Ebrahimi
Background and aims: Primary hypertension, an unexplained increase in blood pressure (BP), accounts for 90% of the cases of hypertension and remains a critical public health challenge. This study aimed to investigate the effects of 12-week resistance training (RT) on some vasodilators and vasoconstrictors in hypertensive men. Methods: This is a semi-experimental study. A total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic BP [SBP] 140.5±0.3 and diastolic BP [DBP] 90.7±0.0 mm Hg) were randomly divided into the RT (n=20) and non-exercise control (n=20) groups. The 12-week dynamic RT program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). Blood samples were taken from both groups at baseline and weeks 4, 8, and 12. Results: SBP and DBP decreased by -8.19±2.46 mm Hg (P=0.039) and -1.19±0.02 mm Hg (P=0.033) from baseline at week 12 in the RT group, respectively, compared to the control group (SBP; 8.22±2.49, P=0.04; DBP; -1.19±0.03, P=0.032). Adiponectin, apelin, atrial natriuretic peptide (ANP), and paraoxonase-1 (PON-1) serum levels increased from baseline at weeks 8 (P=0.01) and 12 (P=0.01), while endothelin-1 (ET-1) and H2 O2 decreased from baseline at weeks 8 (P=0.01) and 12 (P=0.01) in the RT in comparison to the control group. Conclusion: Overall, 12-week RT led to an increase in apelin, ANP, PON-1, and adiponectin. Increasing these markers reduces H2 O2 and ET-1, thus decreasing SBP and DBP in hypertensive men.
背景和目的:原发性高血压是一种无法解释的血压升高，占高血压病例的90%，仍然是一个重大的公共卫生挑战。本研究旨在探讨12周阻力训练(RT)对高血压男性血管舒张剂和收缩剂的影响。方法:半实验研究。选取40例中度高血压(收缩压[SBP] 140.5±0.3，舒张压[DBP] 90.7±0.0 mm Hg)的中年男性(45.3±3.2岁)，随机分为RT组(n=20)和非运动对照组(n=20)。为期12周的动态RT计划以80%的强度进行，每次最多重复一次，每周3天(3组8次重复/每周3天)。两组分别在基线和第4、8、12周采集血样。结果:第12周时，与对照组相比，RT组收缩压和舒张压分别下降-8.19±2.46 mm Hg (P=0.039)和-1.19±0.02 mm Hg (P=0.033)。8.22±2.49,P = 0.04;菲律宾;-1.19±0.03,P = 0.032)。血清脂联素、apelin、心房钠肽(ANP)和对氧磷酶-1 (PON-1)水平在第8周和第12周较基线升高(P=0.01)，内皮素-1 (ET-1)和H2 O2水平在第8周和第12周较基线降低(P=0.01)。结论:总体而言，12周的RT导致apelin、ANP、PON-1和脂联素的增加。增加这些指标可降低H2 O2和ET-1，从而降低高血压患者的收缩压和舒张压。
{"title":"The effect of resistance training on blood pressure, apelin, ANP, PON1, adiponectin, H2O2, and ET-1 in hypertensive men","authors":"Behrouz Baghaiee, Nasibeh Dolatabadi Farahani, Linda S Pescatello, Elshan Davaran Hagh, K. Ebrahimi","doi":"10.34172/jsums.2023.726","DOIUrl":"https://doi.org/10.34172/jsums.2023.726","url":null,"abstract":"Background and aims: Primary hypertension, an unexplained increase in blood pressure (BP), accounts for 90% of the cases of hypertension and remains a critical public health challenge. This study aimed to investigate the effects of 12-week resistance training (RT) on some vasodilators and vasoconstrictors in hypertensive men. Methods: This is a semi-experimental study. A total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic BP [SBP] 140.5±0.3 and diastolic BP [DBP] 90.7±0.0 mm Hg) were randomly divided into the RT (n=20) and non-exercise control (n=20) groups. The 12-week dynamic RT program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). Blood samples were taken from both groups at baseline and weeks 4, 8, and 12. Results: SBP and DBP decreased by -8.19±2.46 mm Hg (P=0.039) and -1.19±0.02 mm Hg (P=0.033) from baseline at week 12 in the RT group, respectively, compared to the control group (SBP; 8.22±2.49, P=0.04; DBP; -1.19±0.03, P=0.032). Adiponectin, apelin, atrial natriuretic peptide (ANP), and paraoxonase-1 (PON-1) serum levels increased from baseline at weeks 8 (P=0.01) and 12 (P=0.01), while endothelin-1 (ET-1) and H2 O2 decreased from baseline at weeks 8 (P=0.01) and 12 (P=0.01) in the RT in comparison to the control group. Conclusion: Overall, 12-week RT led to an increase in apelin, ANP, PON-1, and adiponectin. Increasing these markers reduces H2 O2 and ET-1, thus decreasing SBP and DBP in hypertensive men.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133730991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare adult neoplasm. The primary treatments for UESL are total surgical resection and adjuvant multiagent chemotherapy. The current study presents a case of UESL in a 9-year-old female with abdominal pain and fever as her first symptoms. A cystic mass with solid components was discovered on sonography and computed tomography (CT) imaging. The patient underwent tumor removal surgery in addition to a liver lobectomy on the right side. The pathologist reported a single-focal cystic solid mass confined to the liver with no capsular invasion, and the final diagnosis based on the immunohistochemistry (IHC) results was UESL. The patient received chemotherapy, and she is doing well eight months after surgery with no signs of recurrence. In conclusion, large cystic hepatic lesions should be considered in the differential diagnosis. Despite the poor prognosis of UESL, aggressive surgical resection should be the most important factor in ensuring long-term survival.
{"title":"Undifferentiated embryonal sarcoma of the liver in a 9-year-old girl","authors":"Shima Rahmati, Kiavash Fekri","doi":"10.34172/jsums.2023.735","DOIUrl":"https://doi.org/10.34172/jsums.2023.735","url":null,"abstract":"Undifferentiated embryonal sarcoma of the liver (UESL) is a rare adult neoplasm. The primary treatments for UESL are total surgical resection and adjuvant multiagent chemotherapy. The current study presents a case of UESL in a 9-year-old female with abdominal pain and fever as her first symptoms. A cystic mass with solid components was discovered on sonography and computed tomography (CT) imaging. The patient underwent tumor removal surgery in addition to a liver lobectomy on the right side. The pathologist reported a single-focal cystic solid mass confined to the liver with no capsular invasion, and the final diagnosis based on the immunohistochemistry (IHC) results was UESL. The patient received chemotherapy, and she is doing well eight months after surgery with no signs of recurrence. In conclusion, large cystic hepatic lesions should be considered in the differential diagnosis. Despite the poor prognosis of UESL, aggressive surgical resection should be the most important factor in ensuring long-term survival.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122074686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aims: Sexual satisfaction (SS) and a desirable quality of sex life are known as prerequisites for the physical and mental health of individuals. This study was designed to evaluate the role of the first childbirth and its associated factors in life satisfaction and the quality of life of married women in Shahrekord. Methods: This self-control cohort study was conducted on 124 married women who were planning to have their first pregnancy from January 2018 to February 2019. The convenience sampling method was used to select the samples. The questionnaires utilized in this research included the Demographic Information Questionnaire, the Married Women’s Sexual Satisfaction Questionnaire, and the Sexual Quality of Life-Female Questionnaire. The data were analyzed by independent t test, chi-square, and Pearson correlation coefficient using SPSS, version 22. Results: The mean scores of SS and the quality of sexual life before pregnancy and one year after delivery were 63.45±13.62 and 52.38±13.59, as well as, 88.40±14.19 and 71.08±13.29, respectively. In this study, there was a significant relationship (P±0.041) between changing the quality of sexual life and good economic status of individuals, as well as irregular menstrual status and contraceptive methods (natural birth control). Further, the relationship between residence and change in SS was significant so that people living in cities had the most change in SS compared to those living in rural areas (P±0.046). Conclusion: SS and its dimensions, including physical and psychological barriers, dominant cultural values, and husband-related factors, as well as the mean score of the quality of sex life one year after delivery, were lower than before pregnancy.
背景和目的:性满足和理想的性生活质量被认为是个人身心健康的先决条件。本研究旨在评估首次生育及其相关因素对沙赫里科德已婚妇女生活满意度和生活质量的影响。方法:对2018年1月至2019年2月计划首次怀孕的124名已婚女性进行自我控制队列研究。采用方便抽样法对样本进行选择。本研究使用的问卷包括《人口统计信息问卷》、《已婚妇女性满意度问卷》和《性生活质量女性问卷》。数据采用独立t检验、卡方检验和Pearson相关系数分析，采用SPSS, version 22。结果:孕妇孕前、产后1年性生活质量得分分别为63.45±13.62分、52.38±13.59分、88.40±14.19分、71.08±13.29分。在本研究中，性生活质量的改变与个体良好的经济状况、月经不规律和避孕方法(自然节育)之间存在显著的相关关系(P±0.041)。此外，居住与SS变化的关系显著，居住在城市的人比居住在农村的人SS变化最大(P±0.046)。结论:产后1年妇女的性生活质量及其生理、心理障碍、主流文化价值观、丈夫相关因素等维度，以及性生活质量平均得分均低于孕前。
{"title":"Role of the First Childbirth and its Associated Factors on Sexual Satisfaction and the Quality of Sexual Life of Married Women","authors":"S. Shabanian, Akram Karami Dehkordi, Dariush Gholipour Mofrad-Dashtaki, Parastoo Yarmohammadi-Samani, Saeid Heidari-Sourshajani","doi":"10.34172/jsums.2023.610","DOIUrl":"https://doi.org/10.34172/jsums.2023.610","url":null,"abstract":"Background and aims: Sexual satisfaction (SS) and a desirable quality of sex life are known as prerequisites for the physical and mental health of individuals. This study was designed to evaluate the role of the first childbirth and its associated factors in life satisfaction and the quality of life of married women in Shahrekord. Methods: This self-control cohort study was conducted on 124 married women who were planning to have their first pregnancy from January 2018 to February 2019. The convenience sampling method was used to select the samples. The questionnaires utilized in this research included the Demographic Information Questionnaire, the Married Women’s Sexual Satisfaction Questionnaire, and the Sexual Quality of Life-Female Questionnaire. The data were analyzed by independent t test, chi-square, and Pearson correlation coefficient using SPSS, version 22. Results: The mean scores of SS and the quality of sexual life before pregnancy and one year after delivery were 63.45±13.62 and 52.38±13.59, as well as, 88.40±14.19 and 71.08±13.29, respectively. In this study, there was a significant relationship (P±0.041) between changing the quality of sexual life and good economic status of individuals, as well as irregular menstrual status and contraceptive methods (natural birth control). Further, the relationship between residence and change in SS was significant so that people living in cities had the most change in SS compared to those living in rural areas (P±0.046). Conclusion: SS and its dimensions, including physical and psychological barriers, dominant cultural values, and husband-related factors, as well as the mean score of the quality of sex life one year after delivery, were lower than before pregnancy.","PeriodicalId":318974,"journal":{"name":"Journal of Shahrekord University of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130000397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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