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Reduction of free radicals in hyperglycemic conditions through the administration of lime peel extract (Citrus aurantifolia swingle) 通过施用酸橙皮提取物(Citrus aurantifolia swingle)减少高血糖状态下的自由基
Pub Date : 2022-09-09 DOI: 10.21927/ijnd.2021.9(3).139-144
R. V. Suryadinata, Kezia Sefania, Sawitri Boengas

ABSTRAK

Latar Belakang: Kondisi hiperglikemia tidak selalu terjadi pada penderita diabetes. Stress oksidatif merupakan salah satu proses pathogenesis yang ditimbulkan terhadap penyakit akibat hiperglikemia. Hal tersebut berkaitan dengan peningkatan Reactive Oxygen Species (ROS) dan penurunan aktivitas antioksidan. Pemberian asupan antioksidan dari luar tubuh diharapkan dapat membantu menetralisir radikal bebas yang berlebihan.

Tujuan: Untuk mengetahui efektivitas ektrak kulit jeruk nipis terhadap pernurunan radikal bebas pada kondisi hiperglikemia. 

Metode: Penelitian ini merupakan eksperimental dengan post-test control group design dengan menggunakan tikus wistar di laboratorium Fakultas Kedkteran, Universitas Surabaya. Kondisi hiperglikemia pada hewan coba dilakukan melalui induksi aloksan dan selanjutnya diberikan ekstrak kulit jeruk nipis (2,35 mg; 4,7 mg; 9,4 mg) selama 30 hari dengan membagi menjadi 5 kelompok perlakukan. Parameter untuk mengetahui kadar radikal bebas pada penelitian ini adalah kadar malondialdehid.

Hasil: Pada penelitian memperlihatkan bahwa pada kelompok yang diberikan ektrak kulit jeruk nipis akan mengalami penurunan kadar malondialdehid jika dibandingkan dengan kelompok lainnya (p<0,05). Hasil rerata kadar malondialdehid terendah pada dosis 9,4 mg (1,67±0,10).

Kesimpulan: Pemberian ekstrak kulit jeruk nipis dapat menurunkan kadar malondialdehid pada kondisi hiperglikemia.

 

KATA KUNCI: Citrus aurantifolia; hiperglikemia; malodialdehid; radikal bebas

 

 

ABSTRACT

Background: Hyperglycemia condition does not always occur in diabetes. Oxidative stress is a process of pathogenesis diseases as a result of hyperglycemia. This is associated with increased Reactive Oxygen Species (ROS) and decreased antioxidant activity. Antioxidants intakes outside the body is expected to neutralize excessive free radicals.

Objectives: To determine the effectiveness of lime peel extract against free radicals induced by hyperglycemia.

Methods: This research is an experimental post-test control group design using wistar rats in the laboratory of the Faculty of Medicine, University of Surabaya. Hyperglycemia conditions in experimental animals were carried out through alloxan induction and then given lime peel extract (2,35 mg; 4,7 mg; 9,4 mg) for 30 days by dividing into 5 treatment groups. The parameter to determine the levels of free radicals in this study is the levels of malondialdehyde

Results: Showed that the group given lime peel extract experienced a decrease in malondialdehyde levels when compared to the other groups (p<0.05). The lowest

缺乏症:高血糖并不总是发生在糖尿病患者身上。氧化应激是导致高血糖引起疾病的病理之一。这与反应性氧物种的增加和抗氧化剂活性的减少有关。预计身体外部增加抗氧化剂摄入,有助于中和多余的自由基。目的:了解橘子皮分泌在高血糖条件下对自由基沙漠化的作用。方法:这项研究是后测试控制小组设计的试验性研究,该实验在泗水大学kedktran学院的实验室中使用了wistar鼠标。动物的高血糖状态是通过诱导脱氧核糖核酸(2.35 mg)进行的4.7 mg;9.4 mg) 30天,分成5组治疗。确定本研究自由基水平的参数是马宏迪希德水平。结果:研究表明,与其他群体相比,酸橙皮萃取物的含量会下降关键词:Citrus aurantifolia;血糖过高;malodialdehid;激进的抽象背景:高血糖情况并不总是出现在糖尿病中。应力性应力是导致病理性病变的过程,是导致高血糖症的结果。这是一种增加的反应氧物种和反氧化反应反应的关系。抗氧化剂和药物被带到体外受精自由激进分子。目标:确定莱姆·皮尔反对自由激进分子被高血糖症诱发的效果。方法:这项研究是一种测试后控制小组设计,在泗水大学的著名医学实验室中使用wistar rats。动物实验中的高甘油条件反射通过异质生产而被肢解,然后提供lime peel extract (2.35 mg;4.7 mg;9.4毫克)30天,分成5个小组。《自由激进分子的水平到个重大参数in this study malondialdehydeResults之水平:那里那是集团给lime皮尔当compared to extract经历a decrease in malondialdehyde水平之其他集团(pConclusion:《管理局lime皮尔extract malondialdehyde之能减少水平induced by hyperglycemia。KEYWORDS: Citrus aurantifolia;自由激进分子;hyperglycemia;malondialdehyde
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引用次数: 0
The Association between Sleep Duration, Breakfast Routine and Nutritional Status in Indonesian Adolescents during COVID-19 Pandemic COVID-19大流行期间印度尼西亚青少年睡眠时间、早餐常规和营养状况之间的关系
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.168-180
Muhammad Nadzir Mushoffa Suja’I, Reny Noviasty, E. Kurniawati, R. W. Wisnuwardani
Background: Adolescents are susceptible to nutritional status issues, both undernutrition, and over-nutrition, becoming a public health concern promptly. There were 912 junior and high-school adolescents who were obese and 249 high-school adolescents who had low body mass index (BMI) in Samarinda City. During the COVID-19 pandemic, adolescents experienced changes in sleep duration, and many adolescents were skipping breakfast. Sleep duration and breakfast can affect the nutritional condition of adolescents. Objectives: The purpose of this study was to determine the association between sleep duration, breakfast routine and BMI in Samarinda, Indonesian adolescents during COVID-19 pandemic.Materials and Methods: A total of 340 adolescents was sampled and assessed using a cross-sectional technique to ascertain their sleep duration, breakfast routine, and nutritional status. Nutritional status was classified based on BMI-for-age and z-value BMI. The amount of sleep duration was calculated by the average wake time and sleep time. Breakfast routine was obtained from seven days of breakfast before 9 am. Then, using multivariate analyses were tested for sleep duration, BMI z-value, breakfast routine, and nutritional status.Results: This study revealed that 68.5% had good nutrition, with an average sleep duration of 8 hours (65.9%) and irregular breakfast (59.1%). Nutritional status was significantly influenced by breakfast routine (p=0.044), gender (p<0.001), and mother’s employment (p<0.001). A cubic association was found between sleep duration and BMI (p=0.045); and a significant association between breakfast routines and BMI, independent from age, gender, ethnicity, school.Conclusion: Adolescents must consider their sleep duration and the frequency and composition of their breakfast. Future study in the longitudinal study is needed to explore in more detail.
背景:青少年容易受到营养状况问题的影响,包括营养不足和营养过剩,这迅速成为一个公共卫生问题。萨马林达市有912名初中和高中青少年肥胖,249名高中青少年体重指数(BMI)低。在2019冠状病毒病大流行期间,青少年的睡眠时间发生了变化,许多青少年不吃早餐。睡眠时间和早餐会影响青少年的营养状况。目的:本研究的目的是确定COVID-19大流行期间印度尼西亚萨马林达青少年的睡眠时间、早餐常规和BMI之间的关系。材料和方法:采用横断面技术对340名青少年进行抽样和评估,以确定他们的睡眠时间、早餐习惯和营养状况。根据年龄BMI和z值BMI对营养状况进行分类。睡眠时间的长短由平均清醒时间和平均睡眠时间计算得出。早餐程序从7天早上9点前的早餐中获得。然后,使用多变量分析测试睡眠时间、BMI z值、早餐常规和营养状况。结果:68.5%的人营养状况良好,平均睡眠时间为8小时(65.9%),早餐不规律(59.1%)。营养状况受早餐习惯(p=0.044)、性别(p<0.001)和母亲职业(p<0.001)的显著影响。睡眠时间与BMI呈立方相关(p=0.045);早餐习惯和体重指数之间存在显著关联,与年龄、性别、种族、学校无关。结论:青少年必须考虑他们的睡眠时间和早餐的频率和成分。在今后的纵向研究中还需要进行更详细的探讨。
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引用次数: 1
Improvement of Students and Snack Vendors Behavior After Received Health Promotion Program from UKS’s Cadres 接受英国干部健康促进计划后学生和小吃摊贩行为的改善
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.189-199
R. Pasaribu, Oslida Marthony, Sri Supriyantini, D. N. Iswarawanti
Background: School Health Program or UKS aims to improve  students learning achievement by improving their health status including the fulfillment of nutrition so that they can grow and develop optimally. The nutritional problems of school-age children in Indonesia, according to Riskesdas 2018 data, are children with the short/stunting category reaching 30.7%, while those who are obese are 8% and anemic 26%. Nutritional problems in school children will affect the quality of human resources in the future. Objectives: This study examined the effect of promoting healthy and safe snacks by UKS’s cadres on increasing knowledge, attitudes, behavior of students and snack sellers.Materials and Methods: The first stage of research was training elementary school students UKS’s cadres who will become educators on promoting healthy and safe food consumption behavior. The second stage was assessed to 360 randomly selected students and 94 school vendors in 12 different schools. The intervention schools received a package of promotions delivered by UKS’s cadres while the comparison group received the poster. Data on knowledge, attitudes, behavior of students and food sellers were collected using a questionnaire instrument. The data were collected by the researchers assisted by 12 enumerators, 6 research field assistants and 12 teachers in charge of the research field. Bivariate analysis using t-test, Wilcoxon test, and Mann Whitney test were used to assess the differences between the groups. Results: After intervention by UKS.s cadres, there was a change in students' knowledge of 51.1% for knowledge of healthy snacks, 52.8% about safe snacks, 82.8% about formalin, 62.8% about borax, and 75.6% about Rhodamine B. Changes in the behavior of snack sellers, the highest percentage of changes in holding food with tools is 62.5% and not holding food after holding money is 54.2%. Increased change were significantly higher in the intervention groups than the comparison group (p <0.05).Conclusion: The UKS’s cadres as trained peer-educators could significantly improve safe and healthy food behavior of students as well as knowledge of snack school vendors. UKS’s cadres as promoters of healthy and safe snacks can be used as a mandatory UKS program in school to achieve food safety for school children
背景:学校健康计划或英国旨在提高学生的学习成绩,通过改善他们的健康状况,包括营养的实现,使他们能够最佳地成长和发展。根据Riskesdas 2018年的数据,印度尼西亚学龄儿童的营养问题是,身高不足/发育迟缓的儿童占30.7%,肥胖儿童占8%,贫血儿童占26%。学龄儿童的营养问题将影响未来人力资源的质量。目的:本研究考察了英国干部宣传健康安全零食对提高学生和零食销售商的知识、态度和行为的影响。材料和方法:研究的第一阶段是培训小学生英国的干部,他们将成为促进健康和安全食品消费行为的教育者。第二阶段是在12所不同学校随机抽取360名学生和94名学校摊贩进行评估。干预学校收到了由英国干部提供的一揽子促销活动,而对照组收到了海报。采用问卷调查法收集学生和食品销售商的知识、态度、行为等方面的数据。数据由12名普查员、6名研究现场助理和12名负责研究现场的教师协助研究人员收集。双变量分析采用t检验、Wilcoxon检验和Mann Whitney检验评估组间差异。结果:经UKS干预后。其中,学生对健康零食、安全零食、福尔马林、硼砂、罗丹明b知识的知识变化率分别为51.1%、52.8%、82.8%、62.8%和75.6%。零食销售者行为的变化,用工具拿食物的变化率最高,为62.5%,拿钱后不拿食物的变化率为54.2%。干预组升高的变化明显高于对照组(p <0.05)。结论:通过培训的同侪教育工作者可以显著提高学生的安全健康饮食行为和小吃学校摊贩的知识。UKS干部作为健康安全零食的推动者可以作为UKS在学校的强制性计划,以实现学童的食品安全
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引用次数: 0
Provision of Local Food-Based Formula Using Pila Ampullacea, Tempeh, and Moringa Oleifera Leaves to the Acceptability and Nutrition Intake in Hemodialysis Patients 使用壶肉、天贝和辣木叶的当地食物配方对血液透析患者的可接受性和营养摄入的影响
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.95-102
Fery Lusviana Widiany, Mochammad Sja’bani, S. Susetyowati, E. Huriyati
Background: One of the actions that can be taken to overcome malnutrition in hemodialysis is to improve nutrient intake. It is necessary to provide local food-based formula using Pila ampullacea, tempeh with local soybean, and Moringa oleifera leaves for hemodialysis patients.Objective: To analyze the effect of local food-based formula using Pila ampullacea, tempeh, and Moringa oleifera leaves to the acceptability and nutrition intake in hemodialysis patients.Materials and Methods: This study was carried out in Dr. Sardjito Hospital, Yogyakarta, Indonesia from February to March 2020. Subjects were 54 maintenance hemodialysis patients who met the criteria of study. The independent variable was the provision of local food-based formula, while the dependent variable were the acceptability and nutrition intake.Results: As many as 42.59% of subjects were able to consume all the formula given for three days and 50% of subjects have good acceptance of the local food-based formula. The effect of formula intake to the total intake of energy, carbohydrates, fiber, water, calcium, phosphorus, iron showed p-value <0.05, but p-value ≥0.05 for protein, fat, sodium, and potassium. The effect of the non-formula intake to the total intake for all nutrients showed p-value <0.05.Conclusion: Most of the subjects have a good acceptance of the local food-based formula. Formula intake affects total intake of energy, carbohydrates, fiber, water, calcium, phosphorus, and iron, but does not affect total intake of protein, fat, sodium, and potassium. The total intake for all nutrients was affected by the subject's intake of non-formula sources. 
背景:改善营养摄入是克服血液透析患者营养不良的措施之一。有必要为血液透析患者提供以壶肉、豆豉和辣木叶为原料的当地食品配方。目的:分析壶肉、豆豉、辣木叶当地食物配方对血液透析患者接受度和营养摄入的影响。材料和方法:本研究于2020年2月至3月在印度尼西亚日惹的Dr. Sardjito医院进行。研究对象为54例符合研究标准的维持性血液透析患者。自变量为当地食品配方的提供,因变量为可接受性和营养摄入量。结果:42.59%的受试者能够在3天内吃完所有给药配方,50%的受试者对当地食物配方有良好的接受度。配方饲料采食量对能量、碳水化合物、纤维、水、钙、磷、铁总采食量的影响p值<0.05,对蛋白质、脂肪、钠、钾总采食量的影响p值≥0.05。非配方日粮对各营养物质总日粮的影响p值均<0.05。结论:大部分受试者对当地食基配方奶有较好的接受度。配方奶粉的摄入量影响能量、碳水化合物、纤维、水、钙、磷和铁的总摄入量,但不影响蛋白质、脂肪、钠和钾的总摄入量。所有营养素的总摄入量受到受试者非配方来源摄入量的影响。
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引用次数: 0
Prevalence of Anemia and Correlation with Knowledge, Nutritional Status, Dietary Habits among Adolescent Girls at Islamic Boarding School 伊斯兰寄宿学校女生贫血患病率及其与知识、营养状况、饮食习惯的关系
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.114-121
Aras Utami, A. Margawati, Dodik Pramono, D. Wulandari
Background: Anemia is a globally public health problem, including in Indonesia (22.2%) and it has negative health impacts. Adolescent girls have high risk of anemia. Previous studies reported that adolescent girls at islamic boarding school had low food intake and poor knowledge about nutrition in preventing anemia. Objectives: To assess the prevalence of anemia and to analyze association between knowledge, nutritional status, and dietary habits and anemia in adolescent girls. Materials and Methods: A cross-sectional study was conducted in November 2020 among adolescent girls at islamic boarding school in Semarang. A total of 162 respondents were selected by cluster sampling. Anemia was determined by measuring the hemoglobin level in the blood by Cyanmethemoglobin method. Knowledge and dietary habits were collected through questionnaires. Nutritional status was assessed by measuring weight and height, then classified by body mass index for age using WHO Anthro. Bivariate and multivariate logistic analysis were used to test hypothesis and it was significant if p<0.05. Results: The prevalence of anemia was found to be 17.3%. In the bivariate analysis, overweight was more likely to have anemia (p=0.044). There was no association between father’s education, mother’s education, knowledge, frequency of staple food, breakfast habits, consumption of animal side dishes, consumption of vegetable side dishes, consumption of sweet tea and anemia. Mulitvariate model showed that overweight (OR=3.658; 95%CI=1.224-10.932; p=0.020) and good knowledge (OR=3.652; 95%CI=1.221-10.922; p=0.020) were significant associated with the anemia.Conclusion: Nutritional status and knowledge were significantly associated with anemia among adolescent girls.
背景:贫血是一个全球性的公共卫生问题,包括在印度尼西亚(22.2%),它对健康有负面影响。青春期女孩患贫血的风险很高。先前的研究报告称,伊斯兰寄宿学校的青春期女孩食物摄入量低,对预防贫血的营养知识缺乏了解。目的:评估少女贫血的患病率,分析知识、营养状况和饮食习惯与贫血的关系。材料和方法:2020年11月,在三宝垄伊斯兰寄宿学校的青春期女孩中进行了一项横断面研究。采用整群抽样的方法,选取了162名调查对象。用氰高铁血红蛋白法测定血液中的血红蛋白水平来判断贫血。通过问卷调查收集知识和饮食习惯。通过测量体重和身高来评估营养状况,然后使用世卫组织的人体质量指数对年龄进行分类。采用双变量和多变量logistic分析进行假设检验,p<0.05为显著性。结果:本组患者贫血率为17.3%。在双变量分析中,超重更容易患贫血(p=0.044)。父亲受教育程度、母亲受教育程度、知识、主食频率、早餐习惯、食用动物配菜、食用蔬菜配菜、食用甜茶与贫血之间没有关联。多变量模型显示超重(OR=3.658;95%可信区间= 1.224 - -10.932;p=0.020)和良好的知识(OR=3.652;95%可信区间= 1.221 - -10.922;P =0.020)与贫血显著相关。结论:营养状况和营养知识与青春期少女贫血有显著关系。
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引用次数: 4
Differences in eating habits and physical activity before and during distance learning 远程学习前后饮食习惯和身体活动的差异
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.122-134
Yulia Rizki Maulina, A. Margawati, R. Purwanti, A. Tsani
Background: The COVID-19 pandemic has led to the enforcement of distance learning. This may cause negative impacts on adolescents' eating habits and physical activity.Objectives: This study aimed to analyse the differences in eating habits and physical activity before and during distance learning in adolescents.Materials and Methods: A cross-sectional study was conducted on a sample of 95 adolescents aged between 15-18 years. Subjects were selected using a simple random sampling method. Eating habits and physical activity variables were measured using modified Eating Habit and Lifestyle Changes in COVID-19 and Eating Habits Questionnaire. Wilcoxon Signed-Rank and McNemar tests were used to analyse the data.Results: There was an increase in frequency of meals two times/day (9.5%) and snacking three times/day (4.2%) reported during distance learning. There were significant differences in number of meals (p=0.014) and snacking (p=0.034), carbohydrates sources intake (p=0.046), sweet food (p=0.014), snack (p=0.016), exercise (p=0.035), exercise duration (p=0.004), and exercise frequency (p=0.030) before and during distance learning. There were no significant differences in protein-sources intake, vegetable, fruit, sweetened beverages, fried food, processed food, junk food, emotional eating, physiological eating, and ways of obtaining food before and during distance learning (p >0.05).Conclusion: Significant differences were found in eating habits comprised of the number of main meals and snacking, intake of carbohydrates sources, sweet food, snack, and physical activity before and during distance learning
背景:2019冠状病毒病大流行推动了远程学习的实施。这可能会对青少年的饮食习惯和身体活动造成负面影响。目的:本研究旨在分析青少年远程学习前后饮食习惯和体育活动的差异。材料与方法:对95名15-18岁的青少年进行横断面研究。研究对象采用简单随机抽样方法。使用修改后的COVID-19饮食习惯和生活方式变化和饮食习惯问卷测量饮食习惯和体力活动变量。使用Wilcoxon sign - rank和McNemar检验分析数据。结果:在远程学习期间,每天两次吃饭的频率(9.5%)和每天三次吃零食的频率(4.2%)有所增加。在远程学习前后,学生的用餐次数(p=0.014)和零食(p=0.034)、碳水化合物来源摄入(p=0.046)、甜食(p=0.014)、零食(p=0.016)、运动(p=0.035)、运动持续时间(p=0.004)和运动频率(p=0.030)均存在显著差异。在远程学习前和远程学习期间,蛋白质源摄入量、蔬菜、水果、甜味饮料、油炸食品、加工食品、垃圾食品、情绪性饮食、生理性饮食、获取食物的方式等方面差异均无统计学意义(p >0.05)。结论:远程学习前后学生的饮食习惯有显著差异,包括主餐和零食的数量、碳水化合物来源的摄入、甜食、零食的摄入和体育锻炼
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引用次数: 2
Effect of Moringa (Moringa oleifera) Leaf Flour Supplementation on Total Antioxidant Content of Sprague Dawley Rat Serum Given High-Fat Diet 添加辣木叶粉对高脂日粮大鼠血清总抗氧化剂含量的影响
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.141-149
Sherlin Regina Jami, S. Fatimah-Muis, A. Syauqy, Kusmiyati- Tjahjono, G. Anjani
Background: Moringa oleifera leaf is high in quercetin which can be a source of exogenous antioxidants. Together with endogenous antioxidants, both the antioxidants will be able to counteract oxidative stress conditions.Objectives: To analyze the effect of Moringa leaves flour supplementation on Total Antioxidants Content (TAC) of Sprague Dawley (SD) rat serum given a high-fat diet (HFD). Materials and Methods: A randomized control group post-test design was used on 24 SD rats which were divided into 4 groups, namely healthy control (K1), HFD (K2), supplementation with Moringa leaf flour at a dose of 100 mg/100 g BW/day (K3), and a dose of 200 mg/100 g BW/day (K4). After 28 days of supplementation, serum TAC was analyzed using the ELISA method. Data analysis used Paired-T Test, One Way ANOVA, and Post-Hoc Bonferroni follow-up test.Results: The results showed that the TAC of groups K1, K2, K3, and K4 respectively were 4.806 ± 0.239, 1.323 ± 0.292, 4.020 ± 0.239, and 5.123 ± 0.695. There was a significant difference in serum TAC (p=0.000) between supplementation groups. Significant differences in serum TAC were also found in the supplementation group compared to the HFD control group.Conclusion: Moringa leaves flour supplementation for 28 days at a dose of 200 mg/100 g BW/day increases serum total antioxidant content higher than at a dose of 100 mg/100 g BW/day.
背景:辣木叶富含槲皮素,槲皮素是外源抗氧化剂的来源。与内源性抗氧化剂一起,这两种抗氧化剂将能够抵消氧化应激条件。目的:分析添加辣木叶粉对高脂日粮(HFD) SD大鼠血清中总抗氧化剂含量(TAC)的影响。材料与方法:将24只SD大鼠随机分为健康对照组(K1)、HFD组(K2)、添加辣木叶粉剂量为100 mg/100 g BW/d (K3)和添加辣木叶粉剂量为200 mg/100 g BW/d (K4) 4组。添加28 d后,采用ELISA法分析血清TAC。数据分析采用配对t检验、单因素方差分析和事后Bonferroni随访检验。结果:K1、K2、K3、K4组的TAC分别为4.806±0.239、1.323±0.292、4.020±0.239、5.123±0.695。各添加组间血清TAC差异显著(p=0.000)。与HFD对照组相比,补充组的血清TAC也有显著差异。结论:添加200 mg/100 g BW/d辣木叶粉28 d后血清总抗氧化剂含量高于添加100 mg/100 g BW/d辣木叶粉28 d后血清总抗氧化剂含量高于添加100 mg/100 g BW/d辣木叶粉28 d。
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引用次数: 2
Anthropometric Measurements and Inflammatory Marker in Obese Women 肥胖妇女的人体测量和炎症标志物
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.88-94
Kartika Rizky Aulia, M. Hendrianingtyas, E. K. S. Limijadi, Dodik Pramono
Background: Obesity is one of global epidemic health problems and its prevalence is higher among women. Obesity can cause low grade chronic inflammation mechanism in adipose tissue, which is characterized by the increase of proinflammatory cytokines and adipokines. Neutrophil lymphocyte ratio (NLR) is a simple inflammatory marker which can be reliable in evaluating the inflammatory status occurring in obese women. Waist to height ratio (WHtR) and waist to hip ratio (WHR) are anthropometric measurements, have been reported to be associated with obesity and risk of metabolic syndrome.Objective: This study aimed to determine the correlation of WHtR and WHR with NLR in population of obese women.Materials and Methods: This was a cross sectional study enrolling 80 obese women with Body mass index (BMI) > 27 aged 30 - 50 years in National Diponegoro Hospital Semarang, Indonesia. WHtR was determined by dividing waist circumference by height and WHR was determined by dividing waist circumference by hip circumference. NLR was examined manually from automatic hematology analyzer by dividing absolute neutrophil count (ANC) and absolute lymphocyte count (ALC). Spearman correlation test was performed, p<0.05 was considered as statistically significant.Results: There was significant weak positive correlation between WHtR and NLR in obese women (p = 0,046; r = 0,224). There was no significant correlation between WHR and NLR in obese women (p = 0,961; r = 0,006).Conclusion: The present study showed that WHtR is one of better anthropometric measurement because it is associate with NLR as a simple marker of inflammation in obese women. 
背景:肥胖是全球流行的健康问题之一,其患病率在女性中较高。肥胖可引起脂肪组织的低级别慢性炎症机制,其特征是促炎细胞因子和脂肪因子的增加。中性粒细胞淋巴细胞比率(NLR)是一种简单的炎症标志物,可可靠地评价肥胖妇女的炎症状况。腰高比(WHtR)和腰臀比(WHR)是人体测量指标,据报道与肥胖和代谢综合征的风险有关。目的:探讨肥胖女性人群腰臀比、腰臀比与NLR的相关性。材料和方法:这是一项横断面研究,在印度尼西亚三宝垄国立迪波尼戈罗医院招募了80名体重指数(BMI)为bb27,年龄30 - 50岁的肥胖女性。腰臀比为腰围除以身高,腰臀比为腰围除以臀围。NLR由自动血液学分析仪手工检测,分为绝对中性粒细胞计数(ANC)和绝对淋巴细胞计数(ALC)。Spearman相关检验,p<0.05为差异有统计学意义。结果:肥胖女性WHtR与NLR之间存在显著的弱正相关(p = 0.046;R = 0,224)。肥胖女性WHR和NLR之间无显著相关性(p = 0.961;R = 0.006)。结论:本研究表明,WHtR与NLR作为肥胖女性炎症的简单标志物相关,是较好的人体测量指标之一。
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引用次数: 1
Differences in Development and Diet of Stunting and Non-Stunting Children in the Rowosari Health Center Work Area, Semarang, Indonesia 印度尼西亚三宝垄市Rowosari健康中心工作区内发育迟缓和非发育迟缓儿童的发育和饮食差异
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.161-167
Avionita Latuihamallo, A. Margawati, M. Mexitalia, A. Ediati, A. Syauqy
Background: Stunting in children aged 36-59 months is caused by the intake of energy and protein below the average RDA recommendation. This low consumption has an impact on different growth and development disorders.Objectives: This study aimed to determine the differences in the development and diet of stunted and non-stunted children aged 36-59 months.Materials and Methods: This was an observational study with a cross-sectional approach, which was carried out at the work area of the Rowosari Health Center. The sample population consisted of 67 children aged 36-59 months, which were selected using the simple random sampling technique. The characteristics of the subjects and mothers were then collected using a questionnaire. Meanwhile, data on the diet and child development were obtained with the 24-hour recall method and Developmental Pre-Screening Questionnaire (KPSP), respectively.Results: The results showed that there were differences in the development as well as energy and protein adequacy level of stunted and non-stunted children with a p-value <0.05.Conclusion: There were several deviant developments in non-stunted toddlers due to the lack of nutritional intake, stimulation, interaction with the environment as well as the low knowledge of mothers about child care patterns.
背景:36-59月龄儿童发育迟缓是由于能量和蛋白质摄入量低于平均推荐日摄食量引起的。这种低消耗对不同的生长发育障碍有影响。目的:本研究旨在确定36-59月龄发育迟缓和非发育迟缓儿童在发育和饮食方面的差异。材料和方法:这是一项观察性研究,采用横断面方法,在Rowosari卫生中心的工作区域进行。采用简单随机抽样方法,选取年龄在36-59个月的儿童67名。然后通过问卷调查收集受试者和母亲的特征。同时,采用24小时回忆法和发育预筛选问卷(KPSP)获取饮食和儿童发育数据。结果:发育不良儿童与非发育不良儿童在发育、能量和蛋白质充足性水平上存在差异,p值<0.05。结论:非发育迟缓幼儿由于营养摄入不足、缺乏刺激、与环境的相互作用以及母亲对幼儿保育模式的认识不足等原因,存在多种异常发育。
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引用次数: 1
Effects of Sorghum Cookies (Sorghum Bicolor L. Moench) on Fasting Glucose, Triglyceride, High-Density Lipoprotein level, and Body Fat Percentage in Adolescent Obesity 高粱饼干(Sorghum Bicolor L. Moench)对青少年肥胖空腹血糖、甘油三酯、高密度脂蛋白水平和体脂率的影响
Pub Date : 2022-06-01 DOI: 10.14710/jgi.10.2.181-188
Latifah Rachmawati, M. Mexitalia, M. Muniroh, D. N. Afifah, A. Pramono
Background: Adolescent obesity is related to the risk of metabolic syndrome. Several studies have proven the effect of dietary interventions on metabolic parameters in obese individuals. A source of complex carbohydrates that is still rarely developed in the obese diet is sorghum which contains resistant starch.Objective: The study was to reveal the effect of sorghum cookies on Fasting Glucose (FG), Triglycerides (TG), High-Density Lipoprotein (HDL), and Body Fat Percentage (BFP) in obese adolescents.Materials and Methods: This quasi-experiment with the pre-post control-group design was conducted on 20 boys and 20 girls (divided into 10-boy control group, 10-girl control group, 10-girl intervention group, and 10-girls intervention group) with the age range of 13–15 years who attended Junior High School 14 Semarang chosen by consecutive sampling. Weight, Height, and BFP were measured directly by BIA. Metabolic parameters (FG, TG, and HDL levels) were taken through venous and 10-hour fasting. Energy intake and physical activity were taken by interview using the food recall questionnaire for 6 days randomly and IPAQ. The intervention of sorghum cookies was given in 90 grams/day with 473 kcal/day for 28 days. The analysis of the effect of the intervention was conducted by a paired t-test and independent t-test.Results: At 28-days sorghum cookies intervention resulted in lower levels of FG, TG, and BFP in the intervention boy group (p < 0.05) and BFP in the girl group (p < 0.05). The intervention of sorghum cookies showed no effect on HDL levels in boys, and it did not affect FG, TG, or HDL levels of the girl subjects (p > 0.05). Conclusion: Obese adolescents who had been receiving intervention of 90 grams of sorghum cookies for 28 days appeared to have lower levels of fasting glucose, triglycerides, and body fat percentage.
背景:青少年肥胖与代谢综合征的发生风险相关。一些研究已经证明了饮食干预对肥胖个体代谢参数的影响。复杂碳水化合物的一种来源是含有抗性淀粉的高粱,这在肥胖饮食中仍然很少被开发。目的:研究高粱饼干对肥胖青少年空腹血糖(FG)、甘油三酯(TG)、高密度脂蛋白(HDL)和体脂率(BFP)的影响。材料与方法:本准实验采用前后对照组设计,采用连续抽样的方法,选取13-15岁三宝朗初四年级学生,男、女各20名(分为10男对照组、10女对照组、10女干预组、10女干预组)。通过BIA直接测量体重、身高和BFP。通过静脉和禁食10小时测量代谢参数(FG、TG和HDL水平)。采用随机6 d的食品召回问卷和IPAQ量表对能量摄入和体力活动进行访谈。高粱饼干的干预量为90 g /d,热量为473 kcal/d,连续28 d。干预效果分析采用配对t检验和独立t检验。结果:干预高粱饼干28 d后,干预组男生组FG、TG、BFP水平降低(p < 0.05),干预组女生组BFP水平降低(p < 0.05)。高粱饼干的干预对男孩的HDL水平没有影响,对女孩的FG、TG和HDL水平没有影响(p > 0.05)。结论:肥胖青少年在接受90克高粱饼干干预28天后,空腹血糖、甘油三酯和体脂百分比水平较低。
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引用次数: 0
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Jurnal Gizi Indonesia The Indonesian Journal of Nutrition
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