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Clinical characteristics of takayasu arteritis: A retrospective study from a tertiary care hospital in North India 高须动脉炎的临床特征:来自印度北部一家三级医院的回顾性研究
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_78_20
A. Hegde, Vishal Mangal, Kavita Singh, K. Bhanu, Anurag Jain, V. Vasdev
Introduction: Takayasu's arteritis (TA) is a granulomatous vasculitis of the large vessels, mainly involving the aorta and its branches. The disease has diverse manifestations across various ethnic populations. The epidemiological profile of TA has not been well established in India, with existing studies demonstrating varied clinical findings. Materials and Methods: In this retrospective, hospital record-based study, 30 TA patients, meeting 1990, American College of Rheumatology criteria for TA, were included. The study intended to characterize the demographic profile, clinical characteristics, laboratory parameters, imaging findings, and management profiles of TA, amongst patients presenting to the rheumatology outpatient department of a tertiary care hospital in India. Results: The mean age at presentation was 26.4 ± 11.4 years. The male to female ratio was 1:5. The mean duration from onset of symptoms to point of diagnosis was 8.7 ±5.7 years. Upper limb claudication was the most frequent symptom seen in 23/30 (76.7%) patients, followed by syncope in 12/30 patients (79%). The most common arteries involved were the subclavian artery, carotid artery and the renal arteries (counted together). Type 1 and Type V were the most common angiographic subtypes, each seen in ten (33.3%) patients. Methotrexate was the most frequently used conventional synthetic disease modifying anti-rheumatic drug (csDMARD) and was used in 27/30 (90%) patients. A total of five (16.7%) patients required biological DMARDs (bDMARD) in view of refractory disease, four patients received tocilizumab while one patient received infliximab. Conclusion: TA is a female predominant, large vessel vasculitis. The subclavian arteries, followed by the common carotid and the renal arteries, are the most common vessels involved. Tocilizumab is fast emerging as an effective bDMARD for disease control especially in csDMARD refractory cases.
简介:高松动脉炎(Takayasu’s arteritis, TA)是一种主要累及主动脉及其分支的大血管肉芽肿性血管炎。这种疾病在不同民族人群中有不同的表现。印度尚未很好地确定TA的流行病学概况,现有研究显示了不同的临床结果。材料和方法:在这项基于医院记录的回顾性研究中,纳入了30例符合1990年美国风湿病学会TA标准的TA患者。本研究旨在描述印度一家三级医院风湿病门诊部的患者的人口统计学特征、临床特征、实验室参数、影像学结果和TA的管理概况。结果:平均发病年龄26.4±11.4岁。男女比例为1:5。从症状出现到诊断的平均时间为8.7±5.7年。上肢跛行是最常见的症状,占23/30(76.7%),其次是晕厥(12/30)(79%)。最常见的受累动脉是锁骨下动脉、颈动脉和肾动脉(一起计算)。1型和V型是最常见的血管造影亚型,各占10例(33.3%)。甲氨蝶呤是最常用的常规合成疾病缓解抗风湿药物(csDMARD),有27/30(90%)的患者使用。鉴于难治性疾病,共有5例(16.7%)患者需要生物dmard (bDMARD), 4例患者接受tocilizumab治疗,1例患者接受英夫利昔单抗治疗。结论:TA是一种以女性为主的大血管炎。锁骨下动脉,其次是颈总动脉和肾动脉,是最常见的受累血管。托珠单抗正迅速成为一种有效的bDMARD,用于疾病控制,特别是在csDMARD难治性病例中。
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引用次数: 0
Clinical and biochemical profile of patients with Iron deficiency anemia at a tertiary care hospital 某三级医院缺铁性贫血患者的临床及生化分析
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_65_20
Abhishek Kumar, A. Bharti, L. Meena, V. Tilak
Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia worldwide, especially in adolescent girls, women of reproductive age group, and young children. The clinical presentation and the other biochemical parameters differ in a different age, sex, and geographical group. A study to evaluate the clinical and biochemical profile of patients with IDA at a tertiary care hospital. Materials and Methods: One hundred and two Cases of IDA were taken from the outpatient department (OPD) and ward. After taking consent, the workup was done. Complete history and physical examination were done, and patients were evaluated for signs and symptoms of IDA. Laboratory investigations such as complete blood count with differential count, reticulocyte count, peripheral blood smears, serum iron, total iron binding capacity, serum ferritin, lactic dehydrogenase, stool for occult blood and ova, cysts, liver and renal function were done in all the patients. Results: One hundred and two patients of IDA were enrolled from OPD and ward. The majority of the patients were from the 21 to 30 years age group (25.5%). 37.3% were male and 62.7% were female patients. The main presenting complaint was weakness and easy fatigability (91%). Among the associated comorbidities, the most common were hypertension (13.7%). The majority of the patients had severe pallor (54.9%). Icterus was found in 1.9%. Splenomegaly was found in 4.9%. General blood pictures showed 97.1% had microcytes, 96.1% had hypochromasia and 97.1% had Anisocytosis, which is characteristic of IDA. Conclusion: The majority of patients came to the hospital after developing clinical features due to severe anemia. Therefore, a population based study to evaluate the mild form of IDA or to evaluate a preanemic iron deficiency state can help in the early diagnosis of these patients before they develop severe form.
缺铁性贫血(IDA)是世界范围内最常见的贫血原因,特别是在青春期女孩、育龄妇女和幼儿中。临床表现和其他生化参数在不同的年龄、性别和地理群体中有所不同。评估三级医院IDA患者临床和生化特征的研究材料与方法:选取我院门诊及病房就诊的IDA患者102例。征得同意后,检查就完成了。完成了完整的病史和体格检查,并评估了患者的症状和体征。所有患者均进行全血细胞计数(含差异计数)、网织红细胞计数、外周血涂片、血清铁、总铁结合能力、血清铁蛋白、乳酸脱氢酶、大便隐血及卵、囊肿、肝肾功能等实验室检查。结果:从门诊和病房共纳入了102例IDA患者。患者以21 ~ 30岁年龄组居多(25.5%)。男性占37.3%,女性占62.7%。主要的主诉是虚弱和易疲劳(91%)。在相关合并症中,最常见的是高血压(13.7%)。患者以重度苍白为主(54.9%)。黄疸占1.9%。脾肿大占4.9%。全身血象显示97.1%有小细胞,96.1%有低色度,97.1%有细胞异位,这是IDA的特征。结论:多数患者因重度贫血出现临床特征后前来就诊。因此,以人群为基础的研究来评估轻度IDA或评估贫血前缺铁状态可以帮助这些患者在发展为严重形式之前进行早期诊断。
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引用次数: 0
Selfitis, narcissism, and emotional intelligence: Eliciting the interrelation among medical students in Kolkata, West Bengal 自恋、自恋和情商:西孟加拉邦加尔各答医科学生的相互关系
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_149_20
S. Ray, T. Panja, D. Mukhopadhyay
Introduction: Selfitis, the obsessive behavior to take and share one's own photographs, is a popular activity among young adults. It is growing with the availability of cheap data and free social network services. Scientific literature considers it as an effort to emphasize self-importance in the context of inadequate social support. The aim was to assess the burden of selfitis among medical students and to identify factors associated with it. This cross-sectional study was conducted among 166 students of a medical college in Kolkata, from December 2019 to March 2020. Materials and Methods: The level of selfitis was assessed using the Selfitis Behavior Scale (SBS). Narcissism was evaluated using Narcissistic Personality Inventory-16 and emotional intelligence (EI) was assessed using the mind tool EI questionnaire. Quantitative data were expressed as mean (±standard deviation) or median (±interquartile range) and qualitative data were expressed in frequency and percentage. Binary logistic regression was done with the level of selfitis as a dependent variable and narcissistic trait, EI, and other sociodemographic, individual characteristics as the independent variable. Results: Around one-third (35.5%) of the respondents had borderline selfitis according to SBS. None of the respondents had acute or chronic selfitis. Perceived presence of recreational activity (adjusted odds ratio [AOR] - 15.71), availability of pocket money (AOR - 69.42), family support (AOR - 6.30), and narcissistic trait (AOR - 3.94) were positively associated with borderline selfitis. Conclusions: Around one-third had borderline selfitis. Narcissism and lack of perceived family support were found to be associated with it.
简介:自拍是一种拍摄并分享自己照片的强迫性行为,在年轻人中很流行。随着廉价数据和免费社交网络服务的普及,它正在不断增长。科学文献认为这是在社会支持不足的情况下强调自我重要性的一种努力。目的是评估医学生的自恋负担,并确定与之相关的因素。这项横断面研究是在2019年12月至2020年3月期间对加尔各答一所医学院的166名学生进行的。材料与方法:采用自恋行为量表(SBS)评定自恋水平。采用自恋人格量表(Narcissistic Personality Inventory-16)评估自恋程度,采用情绪智力量表(EI)评估情绪智力。定量资料以均数(±标准差)或中位数(±四分位间距)表示,定性资料以频率和百分比表示。以自恋水平为因变量,自恋特征、EI和其他社会人口学、个体特征为自变量,进行二元logistic回归。结果:约三分之一(35.5%)的受访者根据SBS有边缘性自恋。没有受访者患有急性或慢性自恋。感知存在娱乐活动(调整优势比[AOR]] - 15.71)、可获得零花钱(AOR - 69.42)、家庭支持(AOR - 6.30)和自恋特质(AOR - 3.94)与边缘性自恋呈正相关。结论:约三分之一患有边缘性自恋。研究发现,自恋和缺乏家庭支持与抑郁有关。
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引用次数: 3
A study of COVID-19 with limited testing kits 用有限的检测试剂盒研究COVID-19
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_76_20
Manav K Bhatnagar, A. Bhatnagar, Supriti Bhatnagar
Introduction: In this paper, we consider a fundamental problem of testing faced by the health staff on testing COVID 19 patients. In general, the number of testing kits or testing capabilities is limited, and the number of COVID 19 patients is much larger than that. This paper tries to answer this fundamental question that how to perform COVID 19 testing to reduce the death rate. Materials and Methods: We consider that the survival rate of patients is dependent over two parameters: their age and severity of symptoms at a time. Based on these observations, we propose a survival rate function. Using the survival rates, the death rate for an individual is obtained. MATLAB was used for plotting the graphs. Results: It is shown by numerical results that by using the proposed mechanism, the average death rate can be significantly reduced. Conclusion: It is proposed to conduct the testing for those patients who lie in the high death rate regimen.
本文考虑了卫生工作者在检测COVID - 19患者时面临的一个基本问题。总的来说,检测试剂盒的数量或检测能力有限,而COVID - 19患者的数量远远大于此。本文试图回答如何进行COVID - 19检测以降低死亡率这一基本问题。材料和方法:我们认为患者的存活率取决于两个参数:他们的年龄和症状的严重程度。基于这些观察,我们提出了一个存活率函数。利用存活率,可以得到个体的死亡率。利用MATLAB绘制图形。结果:数值结果表明,采用所提出的机制可显著降低平均死亡率。结论:建议对处于高死亡率方案的患者进行检测。
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引用次数: 3
Assessing self-care perception among caregivers of dementia patients in a rural medical college of Darjeeling District, West Bengal, India 评估印度西孟加拉邦大吉岭地区一所农村医学院痴呆患者护理人员的自我护理认知
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_52_20
A. Layek, N. Ghosh, I. Chakrabarti, N. Bera
Introduction: Dementia is a prevalent cause of morbidity and runs a downhill course. Patients progressively become completely dependent on their caregivers who are usually untrained family members. The resultant burden causes caregiver burnout making them vulnerable to diseases. The objective of this study is to assess perception and practice of self care among caregivers and assess any barriers faced. Materials and Methods: A cross sectional qualitative study with 18 eligible caregivers was conducted from September to December 2019 using the appropriate study tools and techniques. Content analysis was done. Results: Majority were aware that self care was required though only five people practiced it. Medical attention was sought by all. Barriers faced were workload and lack of knowhow. Need for comprehensive domiciliary care structured module with graded nonpharmacological interventions and capacity building was reiterated. Conclusion: Perception regarding self care was present, but practice lacking and barriers faced were mostly lack of training and time constraints. However, a larger study is recommended.
导读:痴呆症是一种普遍的发病原因,并呈下降趋势。病人逐渐变得完全依赖他们的照护者,这些照护者通常是未经训练的家庭成员。由此产生的负担导致护理人员倦怠,使他们容易患病。本研究的目的是评估自我照顾者的认知和实践,并评估所面临的任何障碍。材料与方法:采用适当的研究工具和技术,于2019年9月至12月对18名符合条件的护理人员进行横断面定性研究。进行了内容分析。结果:大多数人意识到自我护理的必要性,尽管只有5人付诸实践。所有人都寻求医疗照顾。面临的障碍是工作量和缺乏专业知识。需要全面的居家护理结构化模块与分级非药物干预和能力建设被重申。结论:患者对自我护理有一定的认知,但缺乏实践,面临的障碍主要是缺乏培训和时间限制。然而,建议进行更大规模的研究。
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引用次数: 0
Managerial challenges in establishing a structured cardiopulmonary resuscitation program in a small health-care setup 在小型卫生保健机构中建立结构化心肺复苏计划的管理挑战
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_120_20
J. Agarwal, J. Das
Introduction: Effective cardiopulmonary resuscitation (CPR) program is required in all health care organizations (HCOs). The focus is primarily on technical aspect of CPR training and managerial challenges encountered in establishment of CPR program are not discussed in detail previously. The aim was to study the managerial challenges in establishing a structured CPR program in a small HCO. A prospective, observational study conducted over a period of 3 months. All staff of the HCO was trained in basic life support. Materials and Methods: A CPR committee was constituted which formulated the CPR policy, CPR rapid response teams (CPR RRT), and training protocols and recorded observations during the study period. Statistical Analysis Used: Mean, percentage, and gain score were used for statistical analysis. Results: The major challenges encountered were unorganized work, lack of resources, old building structure with difficult to access areas, lack of knowledge upgradation, and nonmotivated staff. The clinical staff, involved in regular CPRs, although had basic CPR knowledge, they required continual refresher training. The nonclinical staff showed much larger improvement in scores post training. Conclusions: Flexible functional CPR policy with multidisciplinary CPR RRTs, low dose high frequency training, customized crash kits, interdepartmental liasoning, and mock drills were found useful in making “CPR a reflex manoeuvre” and effective implementation of CPR program. Concepts and principles implemented from organizational behavior, leadership, and motivation such as “Herzbergs Motivational hygiene theory” were useful. Continual training of staff is required for consistent delivery of high quality CPR and even nonmedical staff can be trained to provide high quality Basic Life Support (BLS) similar to clinical staff.
简介:有效的心肺复苏(CPR)计划是所有卫生保健组织(HCOs)所必需的。重点主要放在心肺复苏术培训的技术方面,而在建立心肺复苏术计划时遇到的管理挑战在前面没有详细讨论。目的是研究在小型HCO中建立结构化CPR计划的管理挑战。一项为期3个月的前瞻性观察研究。卫生组织的所有工作人员都接受了基本生命支持方面的培训。材料与方法:成立CPR委员会,制定研究期间的CPR政策、CPR快速反应小组(CPR RRT)、培训方案和观察记录。统计学分析方法:采用平均值、百分比、增益评分进行统计学分析。结果:面临的主要挑战是工作杂乱无章、资源匮乏、建筑结构陈旧、难以进入区域、缺乏知识升级、员工积极性不高。参与常规心肺复苏的临床工作人员,虽然有基本的心肺复苏知识,但他们需要不断的进修培训。非临床工作人员在培训后的得分有了更大的提高。结论:灵活的功能性心肺复苏政策,包括多学科心肺复苏RRTs、低剂量高频训练、定制急救包、部门间联络和模拟演习,有助于使“心肺复苏术成为反射操作”,并有效实施心肺复苏术计划。从组织行为学、领导力和动机中实施的概念和原则,如“赫茨伯格动机卫生理论”是有用的。为了持续提供高质量的心肺复苏术,需要对工作人员进行持续培训,甚至非医务人员也可以接受培训,以提供与临床工作人员类似的高质量基本生命支持(BLS)。
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引用次数: 0
Impact of COVID 19 lockdown on the study of medical students: A cross sectional survey COVID - 19封锁对医学生学习的影响:一项横断面调查
Pub Date : 2020-07-01 DOI: 10.4103/ami.ami_148_20
J. Agarwal, S. Maheshwari, A. Agrawal, M. Pant, Yatika Chaudhary, Manisha Naithani
Introduction: During the pandemic of COVID 19, the traditional teaching of MBBS students has been shifted to online teaching. We conduct an online survey to know and record the impact of COVID 19 lockdown on the study of medical students of GDMC, Dehradun. The present study aimed to investigate the MBBS student's perception of online teaching. The results of this study may provide further inputs which might be of help to the students and faculty for further informed decisions. Materials and Methods: A cross sectional online survey during July 1–7, 2020 was applied to 334 medical students to evaluate the perception of online teaching among medical students. A questionnaire was prepared in Google form and divided into two sections. The first part covered demographics information of the respondent and the second part assessed with behavior and attitude toward online teaching. Results: The mean assessment, behavior, and attitude scores have significantly differed across age groups and previous experience. The medical students who had no exposure to online teaching their assessment score is higher than who had little exposure also found to be significant. The participants were agreed with the teaching way of the course (59.3%) and with the content of the course (56.9%). Majority of participants (58.4%) also agree that there are barriers in online learning. Most of the students agree (62.3%) and strongly agree (61%) that the course allowed them to take responsibility for their learning. Conclusions: We can conclude that the online learning program is a good alternative to classroom teaching in this era of the COVID 19 pandemic. This study can provide the basic architecture for making further strategy of course content.
在新冠肺炎疫情期间,MBBS学生的传统教学已转向在线教学。我们通过在线调查,了解和记录新冠肺炎疫情封锁对德拉敦GDMC医学生学习的影响。本研究旨在探讨MBBS学生对网络教学的认知。这项研究的结果可能会提供进一步的输入,这可能有助于学生和教师进一步明智的决策。材料与方法:于2020年7月1日至7日对334名医学生进行横断面在线调查,评估医学生对网络教学的看法。问卷以Google形式准备,分为两部分。第一部分涵盖了受访者的人口统计信息,第二部分评估了受访者对在线教学的行为和态度。结果:不同年龄、不同经验的学生的平均评估、行为和态度得分存在显著差异。未接触网络教学的医学生的评估分数高于接触网络教学的医学生。参与者对课程的教学方式(59.3%)和课程内容(56.9%)表示满意。大多数参与者(58.4%)也认为在线学习存在障碍。大多数学生同意(62.3%)和强烈同意(61%)课程让他们对自己的学习负责。结论:在新冠肺炎大流行时代,在线学习项目是课堂教学的良好替代方案。本研究可为进一步制定课程内容策略提供基础架构。
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引用次数: 3
Retraction: Oxidative stress and biomarker of tumor necrosis factor alpha, malondialdehyde, and ferric reducing antioxidant power in hypertension 撤回:氧化应激和肿瘤坏死因子α、丙二醛和铁在高血压中降低抗氧化能力的生物标志物
Pub Date : 2020-01-01 DOI: 10.4103/2349-0578.274681
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引用次数: 0
Bedroom design orientation and sleep electroencephalography signals 卧室设计取向与睡眠脑电图信号
Pub Date : 2019-12-01 DOI: 10.4103/ami.ami_60_18
Amin Hekmatmanesh, M. Banaei, K. Haghighi, A. Najafi
Background: Orientation is a significant factor in architectural design that may affect well-being. Body direction does not change during sleeping, and sleeping is sensitive and affected by environmental factors. Aims: This neuroarchitecture study aimed to assess the effects of bed orientation on sleep quality to enhance bedroom design. Materials and Methods: To do so, the effects of earth's electromagnetic field (EMF) on sleep electroencephalography (EEG) signals were evaluated using signal processing techniques. In this cross-sectional study, a total of 21 healthy volunteer participants slept for two consecutive naps, at two rooms with identical interior design and different bed orientations, toward and against earth's EMF in a sleep clinic. Statistical Analysis: In this experiment, discrete wavelet transform extracted five subfrequencies of EEG data as delta, theta, alpha, beta1, and beta2. In addition, the energy signals were computed by measurement of wave frequencies. The mean total sleep time was 1.63 h in North–South (N-S) earth's EMF orientation and 1.38 h in the other direction. Results: t-test results showed significant changes in delta, theta, and alpha frequencies in terms of bed orientation. There was a significant result in the alpha energy ratio over the whole signal energy. Furthermore, there were increases in the average energy of delta, theta, and alpha bands in N-S versus East–West (E-W) bed directions. Conclusions: This study indicated that sleep in N-S direction could be more beneficial than E-W and the sleep EEG signals can be sensitive to earth's EMF. The results show the importance of considering orientation in bedroom design and its benefits on inhabitants' well-being.
背景:朝向是建筑设计中可能影响幸福感的重要因素。睡眠时身体方向不改变,睡眠是敏感的,受环境因素影响。目的:本神经建筑学研究旨在评估床朝向对睡眠质量的影响,以改进卧室设计。材料和方法:为此,使用信号处理技术评估地球电磁场(EMF)对睡眠脑电图(EEG)信号的影响。在这项横断面研究中,共有21名健康的志愿者参与者连续睡了两次午觉,在睡眠诊所的两个房间里,室内设计相同,床的朝向不同,朝向和反对地球的电磁场。统计分析:在本实验中,离散小波变换提取EEG数据的五个子频率分别为delta、theta、alpha、beta1和beta2。此外,通过测量波的频率来计算能量信号。南北(N-S)方向平均总睡眠时间为1.63 h,相反方向为1.38 h。结果:t检验结果显示,delta、theta和alpha频率在床的朝向方面有显著的变化。α能量比在整个信号能量上有一个显著的结果。与东-西(E-W)床向相比,北-南床向δ、θ和α波段的平均能量有所增加。结论:本研究提示南北向睡眠比东西向睡眠更有益,且睡眠脑电图信号对地电动势敏感。结果表明,在卧室设计中考虑朝向的重要性及其对居民幸福感的好处。
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引用次数: 13
Robotic-assisted radical adrenalectomy for large adrenocortical carcinoma 机器人辅助肾上腺根治术治疗肾上腺皮质癌
Pub Date : 2019-07-01 DOI: 10.4103/ami.ami_71_18
Altaf Khan, V. Singh, Muhammed P. Manzoor, M. Mujeeburahiman, Nischith Dsouza
Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy with poor prognosis. Laparoscopic adrenalectomy has been a favorite surgical approach for the treatment of adrenal masses. The use of robotic-assisted surgery is the latest development for minimally invasive surgical management of adrenal masses. Here, we describe a rare case of ACC in a 51-year-old male patient who presented with pain in the lumbar region, and robot-assisted laparoscopic radical adrenalectomy was successfully performed transperitoneally with the assistance of the da Vinci robotic system. We also discuss the summary of clinical features of ACC. Robot-assisted laparoscopic adrenalectomy is safe, is easier with lesser blood loss, and is comfortable to the patient due to its low complication rates. The patient improved after tumor removal.
摘要肾上腺皮质癌是一种罕见且高度侵袭性的恶性肿瘤,预后较差。腹腔镜肾上腺切除术一直是治疗肾上腺肿块的首选手术方法。机器人辅助手术是肾上腺肿块微创手术治疗的最新发展。在此,我们描述了一例罕见的ACC病例,患者为51岁男性,表现为腰椎疼痛,在达芬奇机器人系统的帮助下,机器人辅助的腹腔镜肾上腺根治性切除术成功地经腹腔实施。我们还讨论了ACC的临床特征总结。机器人辅助的腹腔镜肾上腺切除术是安全的,更容易,更少的失血,并且由于其并发症发生率低,对患者来说是舒适的。患者肿瘤切除后病情好转。
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引用次数: 0
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