Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art11
Tito Sumarwoto, Dhimas Hartanto, Pamudji Utomo
Geriatric fractures refer to fractures that occur in older people, typically resulting from low-energy trauma and accompanied by osteoporosis. The bone remodelling process imbalance significantly contributes to age-related bone loss in geriatric, which reduces bone mass, making them more susceptible to fractures. Managing geriatric fractures poses unique challenges due to the presence of other comorbid conditions that can interfere with the healing process. Thus, restoring stability is prioritised over reversing anatomy and biology. The use of medication is often helpful in treating osteoporosis. Diagnosing and managing geriatric fractures is a complex process that requires careful consideration of various comorbid factors associated with older patients. Both non-operative and operative management requires thorough preparation. The primary goal of fracture management in older people is to achieve patient independence. Factors such as age, gender, comorbid conditions, pre-fracture functional abilities, and fracture type can impact the outcome regarding ambulation, daily activities, and quality of life. Therefore, it is essential to consider all these factors while managing geriatric fractures.
{"title":"Managing fractures in geriatrics: Current approaches and update","authors":"Tito Sumarwoto, Dhimas Hartanto, Pamudji Utomo","doi":"10.20885/jkki.vol14.iss1.art11","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art11","url":null,"abstract":"Geriatric fractures refer to fractures that occur in older people, typically resulting from low-energy trauma and accompanied by osteoporosis. The bone remodelling process imbalance significantly contributes to age-related bone loss in geriatric, which reduces bone mass, making them more susceptible to fractures. Managing geriatric fractures poses unique challenges due to the presence of other comorbid conditions that can interfere with the healing process. Thus, restoring stability is prioritised over reversing anatomy and biology. The use of medication is often helpful in treating osteoporosis. Diagnosing and managing geriatric fractures is a complex process that requires careful consideration of various comorbid factors associated with older patients. Both non-operative and operative management requires thorough preparation. The primary goal of fracture management in older people is to achieve patient independence. Factors such as age, gender, comorbid conditions, pre-fracture functional abilities, and fracture type can impact the outcome regarding ambulation, daily activities, and quality of life. Therefore, it is essential to consider all these factors while managing geriatric fractures.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44771882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art12
Gabriella Stephanie Minami, Ellya Catharine Lumbantoruan, Puteri, Risa Nuraini, Joan Carmen Harianto, Andhi Fahrurroji
Consumption of fast food and sedentary lifestyles has recently developed in society. This activity is one of the causes of various degenerative diseases, including cardiovascular disease. Therefore, efforts are needed to prevent it. Sweet orange (Citrus sinensis) is one of the most common types of citrus fruit, with total production reaching 70% of all types. This type of fruit is the most widely produced and consumed by the world’s population. Sweet orange is known for its bioactive compounds that have many benefits in cardiovascular health, such as alkaloids, flavonoids, tannins, phenols, vitamins C, B1, B2, and B3, glycosides, coumarin glycosides, folic acid, some organic acids, essential oils, and saponins. Flavonoids are components of secondary metabolites that play a role in the cardiovascular system. The main components of these compounds are hesperidin and naringenin. Various studies have shown that these compounds are active in reducing hyperlipidemia, improving endothelial function, acting as an anti-inflammatory and anti-atherosclerotic agent, preventing myocardial infarction, and preventing cardiac hypertrophy through various mechanisms with low toxicity.
{"title":"The potential of sweet orange (Citrus sinensis) in cardiovascular health: A literature review","authors":"Gabriella Stephanie Minami, Ellya Catharine Lumbantoruan, Puteri, Risa Nuraini, Joan Carmen Harianto, Andhi Fahrurroji","doi":"10.20885/jkki.vol14.iss1.art12","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art12","url":null,"abstract":"Consumption of fast food and sedentary lifestyles has recently developed in society. This activity is one of the causes of various degenerative diseases, including cardiovascular disease. Therefore, efforts are needed to prevent it. Sweet orange (Citrus sinensis) is one of the most common types of citrus fruit, with total production reaching 70% of all types. This type of fruit is the most widely produced and consumed by the world’s population. Sweet orange is known for its bioactive compounds that have many benefits in cardiovascular health, such as alkaloids, flavonoids, tannins, phenols, vitamins C, B1, B2, and B3, glycosides, coumarin glycosides, folic acid, some organic acids, essential oils, and saponins. Flavonoids are components of secondary metabolites that play a role in the cardiovascular system. The main components of these compounds are hesperidin and naringenin. Various studies have shown that these compounds are active in reducing hyperlipidemia, improving endothelial function, acting as an anti-inflammatory and anti-atherosclerotic agent, preventing myocardial infarction, and preventing cardiac hypertrophy through various mechanisms with low toxicity.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43782367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art8
Yose Waluyo, Sari Rajwani Artika, Insani Nanda Wahyuni, Endy Adnan, Budu, A. Bukhari
Background: Osteoarthritis currently remains a significant health problem due to its high prevalence and morbidity rate. Radiological examination is still used as a gold standard to determine the severity of knee osteoarthritis by using Kellgren-Lawrence grading. Dextrose prolotherapy has been known to be effective in treating pain in knee osteoarthritis, but none has compared the efficacy between mild and moderate-severe knee osteoarthritis. Objective: This study aims to compare the effectiveness of prolotherapy based on its radiological and symptomatic severity in knee osteoarthritis.Methods: In this pre-post study, the participants who underwent dextrose prolotherapy injection (25% intra-articular and 15% periarticular) for three sessions with four weeks intervals were grouped into mild (grade 1-2) and severe (grade 3-4) groups. Participants’ functional status was measured with Western Ontario and McMaster Universities’ arthritis index scores at baseline and week 12.Results: A total of 21 patients (average age 61.42 ± 8.33, BMI 26.81± 3.72) received three therapy sessions. Both groups had significantly better Western Ontario and McMaster Universities arthritis index scores than baseline (-22.57± 11.9; p = 0.002 and -15.42 ± 15.75; p = 0.003). All parameters were improved significantly (p <0.05) in both groups, except the stiffness score (p = 0.292; p = 0.057). There were no differences in functional outcome improvements in both groups (p > 0.05; CI 95%: -21.3 – 7.05).Conclusion: Prolotherapy effectively improves functional outcomes in all stages of knee osteoarthritis.
{"title":"Functional outcome in knee osteoarthritis after dextrose prolotherapy intervention: A severity-based pilot study","authors":"Yose Waluyo, Sari Rajwani Artika, Insani Nanda Wahyuni, Endy Adnan, Budu, A. Bukhari","doi":"10.20885/jkki.vol14.iss1.art8","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art8","url":null,"abstract":"Background: Osteoarthritis currently remains a significant health problem due to its high prevalence and morbidity rate. Radiological examination is still used as a gold standard to determine the severity of knee osteoarthritis by using Kellgren-Lawrence grading. Dextrose prolotherapy has been known to be effective in treating pain in knee osteoarthritis, but none has compared the efficacy between mild and moderate-severe knee osteoarthritis. Objective: This study aims to compare the effectiveness of prolotherapy based on its radiological and symptomatic severity in knee osteoarthritis.Methods: In this pre-post study, the participants who underwent dextrose prolotherapy injection (25% intra-articular and 15% periarticular) for three sessions with four weeks intervals were grouped into mild (grade 1-2) and severe (grade 3-4) groups. Participants’ functional status was measured with Western Ontario and McMaster Universities’ arthritis index scores at baseline and week 12.Results: A total of 21 patients (average age 61.42 ± 8.33, BMI 26.81± 3.72) received three therapy sessions. Both groups had significantly better Western Ontario and McMaster Universities arthritis index scores than baseline (-22.57± 11.9; p = 0.002 and -15.42 ± 15.75; p = 0.003). All parameters were improved significantly (p <0.05) in both groups, except the stiffness score (p = 0.292; p = 0.057). There were no differences in functional outcome improvements in both groups (p > 0.05; CI 95%: -21.3 – 7.05).Conclusion: Prolotherapy effectively improves functional outcomes in all stages of knee osteoarthritis.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41648767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art5
Farikha Dewi Larasati, S. Winarni, A. Mawarni, F. Agushybana
Background: Abortion is associated with 4.7% to 13.2% of maternal deaths. In the Brebes Regency, spontaneous abortion incidence was 15% in 2014, which various factors may cause.Objective: This study aims to analyse the association between maternal age, education level, employment status, and haemoglobin (Hb) levels with the incidence of spontaneous abortion.Methods: This study was a quantitative study using a case-control design. The study comprised a sample of 78 females of childbearing age, including 39 cases and 39 controls. The study utilised questionnaires and blood tests as instruments for data collection. The collected data were analysed using frequency distribution tables and statistical tests, including Chi-Square continuity correction.Results: The results demonstrated that Hb levels were associated with spontaneous abortion (p=0.028). Meanwhile, maternal age (p=1.000), education levels (p=1.000), and employment status (p=0.485) were not associated with spontaneous abortion. Respondents with low Hb levels have a six times greater risk of having a spontaneous abortion than respondents with normal Hb levels (OR=6.379)Conclusion: Low Hb level was a risk factor for spontaneous abortion. Women of childbearing age need to take iron supplements before and during their pregnancy to prevent the dangers of anaemia during pregnancy.
{"title":"Analysis of demographic factors and anaemia of the incidence of spontaneous abortion","authors":"Farikha Dewi Larasati, S. Winarni, A. Mawarni, F. Agushybana","doi":"10.20885/jkki.vol14.iss1.art5","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art5","url":null,"abstract":"Background: Abortion is associated with 4.7% to 13.2% of maternal deaths. In the Brebes Regency, spontaneous abortion incidence was 15% in 2014, which various factors may cause.Objective: This study aims to analyse the association between maternal age, education level, employment status, and haemoglobin (Hb) levels with the incidence of spontaneous abortion.Methods: This study was a quantitative study using a case-control design. The study comprised a sample of 78 females of childbearing age, including 39 cases and 39 controls. The study utilised questionnaires and blood tests as instruments for data collection. The collected data were analysed using frequency distribution tables and statistical tests, including Chi-Square continuity correction.Results: The results demonstrated that Hb levels were associated with spontaneous abortion (p=0.028). Meanwhile, maternal age (p=1.000), education levels (p=1.000), and employment status (p=0.485) were not associated with spontaneous abortion. Respondents with low Hb levels have a six times greater risk of having a spontaneous abortion than respondents with normal Hb levels (OR=6.379)Conclusion: Low Hb level was a risk factor for spontaneous abortion. Women of childbearing age need to take iron supplements before and during their pregnancy to prevent the dangers of anaemia during pregnancy.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45308064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art9
Ni Luh Kadek Alit Arsani, Luh Putu Ratna Sundari
Background: Growth hormone (GH), Insulin-like growth factor 1 (IGF-1), and exercise play a crucial role in female reproductive function. At the perimenopausal age, there is a decrease in GH, estrogen, and testosterone levels. In previous studies, the impact of physical activity on serum IGF-1 levels in geriatric was inconsistent and needed further investigation. Objective: The purpose of this study was to look into the effect of GH and exercise on serum IGF-1 levels in perimenopausal Wistar rats. Methods: It is an experimental study with a randomized posttest-only control group design using 24 perimenopausal Wistar rats aged 14 months as the sample. The control rats (C) were given 0.1 ml of distilled water subcutaneously every day for 30 days. Treatment group 1 (T1) rats swam for 30 minutes at a time five times per week. Meanwhile, rats of T2 were given 0.016 IU/0.1ml GH daily injection subcutaneously only for 30 days and T3 were given combination both of GH injection in same dose and swam for 30 minutes at a time 5 times a week for 30 days Data analysis used One-Way ANOVA.Results: The finding revealed that the mean serum IGF-1 levels in the T3 (588.50 84.04 ng/mL) were significantly higher than the control (242.03 ± 46.08 ng/mL), T1 (334.23 ± 75.90 ng/mL) and T2 (428.69 ± 95.10 ng/mL). Conclusion: Our study shows that GH administration and exercise combination increases levels of IGF-1 serum higher than only administrated GH or exercise.
{"title":"Growth hormone administration and exercise combination increase serum IGF-1 levels in perimenopausal wistar rats","authors":"Ni Luh Kadek Alit Arsani, Luh Putu Ratna Sundari","doi":"10.20885/jkki.vol14.iss1.art9","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art9","url":null,"abstract":"Background: Growth hormone (GH), Insulin-like growth factor 1 (IGF-1), and exercise play a crucial role in female reproductive function. At the perimenopausal age, there is a decrease in GH, estrogen, and testosterone levels. In previous studies, the impact of physical activity on serum IGF-1 levels in geriatric was inconsistent and needed further investigation. Objective: The purpose of this study was to look into the effect of GH and exercise on serum IGF-1 levels in perimenopausal Wistar rats. Methods: It is an experimental study with a randomized posttest-only control group design using 24 perimenopausal Wistar rats aged 14 months as the sample. The control rats (C) were given 0.1 ml of distilled water subcutaneously every day for 30 days. Treatment group 1 (T1) rats swam for 30 minutes at a time five times per week. Meanwhile, rats of T2 were given 0.016 IU/0.1ml GH daily injection subcutaneously only for 30 days and T3 were given combination both of GH injection in same dose and swam for 30 minutes at a time 5 times a week for 30 days Data analysis used One-Way ANOVA.Results: The finding revealed that the mean serum IGF-1 levels in the T3 (588.50 84.04 ng/mL) were significantly higher than the control (242.03 ± 46.08 ng/mL), T1 (334.23 ± 75.90 ng/mL) and T2 (428.69 ± 95.10 ng/mL). Conclusion: Our study shows that GH administration and exercise combination increases levels of IGF-1 serum higher than only administrated GH or exercise.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47474627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art13
Andre Colin Hartono, V. Sidharta, Yunisa Astiarani, Regina Regina
Globally, there is an increasing prevalence of vitamin D deficiency, including in Southeast Asia, which ranges from 6% to 70%. Vitamin D plays an important role in calcium metabolism and bone health. Melanin is one factor that contributes to vitamin D deficiency. It has photoprotective properties that inhibit vitamin D synthesis, but the mechanism has not been fully understood. To determine the mechanism of the association between melanin and vitamin D, this systematic review was conducted on 11 articles, including cross-sectional studies, cohort studies, and randomised controlled trials published from 2010 to 2020. The search included Pubmed, EBSCO, and Proquest databases, and data were synthesised from 11 studies. This critical review found nine of the 11 studies reported a significant association between melanin and vitamin D, while two reported non-significant results. Of the nine significant studies, eight reported that people with higher melanin have lower vitamin D levels, while one study suggested that melanin levels do not necessarily associate with lower vitamin D levels. In conclusion, the review establishes a significant association between melanin and vitamin D.
{"title":"Association between melanin and vitamin D: A systematic review","authors":"Andre Colin Hartono, V. Sidharta, Yunisa Astiarani, Regina Regina","doi":"10.20885/jkki.vol14.iss1.art13","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art13","url":null,"abstract":"Globally, there is an increasing prevalence of vitamin D deficiency, including in Southeast Asia, which ranges from 6% to 70%. Vitamin D plays an important role in calcium metabolism and bone health. Melanin is one factor that contributes to vitamin D deficiency. It has photoprotective properties that inhibit vitamin D synthesis, but the mechanism has not been fully understood. To determine the mechanism of the association between melanin and vitamin D, this systematic review was conducted on 11 articles, including cross-sectional studies, cohort studies, and randomised controlled trials published from 2010 to 2020. The search included Pubmed, EBSCO, and Proquest databases, and data were synthesised from 11 studies. This critical review found nine of the 11 studies reported a significant association between melanin and vitamin D, while two reported non-significant results. Of the nine significant studies, eight reported that people with higher melanin have lower vitamin D levels, while one study suggested that melanin levels do not necessarily associate with lower vitamin D levels. In conclusion, the review establishes a significant association between melanin and vitamin D.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46268555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art4
Uswatun Hasanah, I. Handayani, Asvin Nurulita
Background: Sepsis is a leading cause of death among critically ill patients with infections. Abnormal levels of C-reactive protein (CRP) and albumin in sepsis patients have been shown to predict mortality. Combining the two markers can increase the predictive value of mortality.Objective: The aim of this retrospective cohort study was to determine the cut-off value for the CRP/albumin ratio that could be used to predict mortality in patients with sepsis. Methods: Secondary data from 63 medical records of sepsis patients treated in the ICU of RSUP dr. Wahidin Sudirohusodo Makassar from January 2018 to December 2020 was used. Statistical analysis was performed using the Kolmogorov-Smirnov and Mann-Whitney tests. The prognostic value of the CRP/albumin ratio was analyzed using the ROC curve to obtain a cut-off value. A p-value < 0.05 was considered significant. Results: The sample included 43 deceased and 20 living patients with sepsis. The CRP/albumin ratio was significantly higher in the deceased patients (15.4) than in the living patients (2.4) (p<0.001). The ROC curve analysis revealed a CRP/albumin cut-off value of 4.3 with a sensitivity of 81.4%, specificity of 75.0%, positive predictive value (PPV) of 87.5%, negative predictive value (NPV) of 65.2%, and an accuracy of 79.4%. Conclusion: The study suggests a significant relationship between the CRP/albumin ratio and mortality in patients with sepsis. A CRP/albumin ratio of 4.3 can be used as a predictor of mortality in sepsis patients.
{"title":"Analysis of C-reactive protein/albumin ratio as a predictor of mortality in sepsis patients","authors":"Uswatun Hasanah, I. Handayani, Asvin Nurulita","doi":"10.20885/jkki.vol14.iss1.art4","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art4","url":null,"abstract":"Background: Sepsis is a leading cause of death among critically ill patients with infections. Abnormal levels of C-reactive protein (CRP) and albumin in sepsis patients have been shown to predict mortality. Combining the two markers can increase the predictive value of mortality.Objective: The aim of this retrospective cohort study was to determine the cut-off value for the CRP/albumin ratio that could be used to predict mortality in patients with sepsis. Methods: Secondary data from 63 medical records of sepsis patients treated in the ICU of RSUP dr. Wahidin Sudirohusodo Makassar from January 2018 to December 2020 was used. Statistical analysis was performed using the Kolmogorov-Smirnov and Mann-Whitney tests. The prognostic value of the CRP/albumin ratio was analyzed using the ROC curve to obtain a cut-off value. A p-value < 0.05 was considered significant. Results: The sample included 43 deceased and 20 living patients with sepsis. The CRP/albumin ratio was significantly higher in the deceased patients (15.4) than in the living patients (2.4) (p<0.001). The ROC curve analysis revealed a CRP/albumin cut-off value of 4.3 with a sensitivity of 81.4%, specificity of 75.0%, positive predictive value (PPV) of 87.5%, negative predictive value (NPV) of 65.2%, and an accuracy of 79.4%. Conclusion: The study suggests a significant relationship between the CRP/albumin ratio and mortality in patients with sepsis. A CRP/albumin ratio of 4.3 can be used as a predictor of mortality in sepsis patients.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42928962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art3
Fathimah Az Zahra, Tri Wahyuliati
Background: Dysmenorrhea or pain during menstruation is due to excessive contractions during the sloughing of the uterine wall with symptoms of cramping pain in the lower abdomen. The incidence of primary dysmenorrhea in Indonesia is 54.89%. However, many teenagers do not know how to manage the pain. The pharmacological therapy of dysmenorrhea includes painkillers and anti-prostaglandin, while the non-pharmacological approach includes distraction therapy. One of the distraction therapy that is easy to do is murottal Al-Qur’an.Objective: This study observed the role of listening to murottal Al-Qur’an on the intensity of dysmenorrhea among senior high school students.Methods: The design of this study is a quasi-experimental pretest-posttest with a control group design. There were 100 subjects aged 15-18 years old. The sampling technique applied purposive sampling. Data analysis of this study applied Wilcoxon, Mann-Whitney, relative risk (RR), and number needed to treat (NNT) test.Results: The mean pain level in the experimental and control group were 5.42 and 5.56 before intervention. After therapy, the pain level decreased to 2.86 and 5.30 in the experimental and control group, respectively. There was a significant difference in the pain level before and after in the experiment group (p <0.001). Relative risk showed that murottal intervention decreases the pain level by 3.267 times. NNT of the study was 1.467.Conclusion: Murottal Al-Qur’an significantly reduced the degree of pain with a p-value <0.001
{"title":"The effect of murottal Al Qur'an on the dysmenorrhea intensity among senior high school students","authors":"Fathimah Az Zahra, Tri Wahyuliati","doi":"10.20885/jkki.vol14.iss1.art3","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art3","url":null,"abstract":"Background: Dysmenorrhea or pain during menstruation is due to excessive contractions during the sloughing of the uterine wall with symptoms of cramping pain in the lower abdomen. The incidence of primary dysmenorrhea in Indonesia is 54.89%. However, many teenagers do not know how to manage the pain. The pharmacological therapy of dysmenorrhea includes painkillers and anti-prostaglandin, while the non-pharmacological approach includes distraction therapy. One of the distraction therapy that is easy to do is murottal Al-Qur’an.Objective: This study observed the role of listening to murottal Al-Qur’an on the intensity of dysmenorrhea among senior high school students.Methods: The design of this study is a quasi-experimental pretest-posttest with a control group design. There were 100 subjects aged 15-18 years old. The sampling technique applied purposive sampling. Data analysis of this study applied Wilcoxon, Mann-Whitney, relative risk (RR), and number needed to treat (NNT) test.Results: The mean pain level in the experimental and control group were 5.42 and 5.56 before intervention. After therapy, the pain level decreased to 2.86 and 5.30 in the experimental and control group, respectively. There was a significant difference in the pain level before and after in the experiment group (p <0.001). Relative risk showed that murottal intervention decreases the pain level by 3.267 times. NNT of the study was 1.467.Conclusion: Murottal Al-Qur’an significantly reduced the degree of pain with a p-value <0.001","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47838207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art2
Hidayu Permata Hardi, I. Soerohardjo, A. Z. Hendri
Background: Bladder cancer (BC) is the tenth most common cancer in both males and females. Early detection can improve the patient's chances of survival, giving patients with BC a good prognosis. The hematological parameter determines the number of leukocytes, hemoglobin, platelets, and Neutrophil-Lymphocyte Ratio (NLR) in the body. The presence of abnormal values on hematological parameters indicates that the patient is in poor condition.Objective: This study aims to compare hematological parameters between early-stage and advanced BC at Dr. Sardjito Hospital.Methods: This study was a retrospective cross-sectional study using patient medical records. By using the results of the anatomical pathology, pre-operative hematology evaluated the influence on the bladder cancer stage. The sample used consisted of 130 bladder cancer patients. Chi-square and regression statistical tests were used to analyze the collected data.Results: The advanced-stage group had considerably higher leukocytosis than the early-stage group (p = 0.000). Anemia predominated more in the later-stage group than in the earlier stage (p = 0.048). Additionally, the advanced-stage group experienced thrombocytosis more frequently than the early-stage group (p = 0.000). NLR was higher in the advanced compared to the early-stage group (p = 0.000).Conclusion: Patients with advanced bladder cancer were more likely to experience abnormal hematological parameters levels than those with the earliest stages of the disease.
{"title":"Analysis of hematological parameters in bladder cancer in early and advanced stages at Dr. Sardjito Hospital","authors":"Hidayu Permata Hardi, I. Soerohardjo, A. Z. Hendri","doi":"10.20885/jkki.vol14.iss1.art2","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art2","url":null,"abstract":"Background: Bladder cancer (BC) is the tenth most common cancer in both males and females. Early detection can improve the patient's chances of survival, giving patients with BC a good prognosis. The hematological parameter determines the number of leukocytes, hemoglobin, platelets, and Neutrophil-Lymphocyte Ratio (NLR) in the body. The presence of abnormal values on hematological parameters indicates that the patient is in poor condition.Objective: This study aims to compare hematological parameters between early-stage and advanced BC at Dr. Sardjito Hospital.Methods: This study was a retrospective cross-sectional study using patient medical records. By using the results of the anatomical pathology, pre-operative hematology evaluated the influence on the bladder cancer stage. The sample used consisted of 130 bladder cancer patients. Chi-square and regression statistical tests were used to analyze the collected data.Results: The advanced-stage group had considerably higher leukocytosis than the early-stage group (p = 0.000). Anemia predominated more in the later-stage group than in the earlier stage (p = 0.048). Additionally, the advanced-stage group experienced thrombocytosis more frequently than the early-stage group (p = 0.000). NLR was higher in the advanced compared to the early-stage group (p = 0.000).Conclusion: Patients with advanced bladder cancer were more likely to experience abnormal hematological parameters levels than those with the earliest stages of the disease.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43339326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.20885/jkki.vol14.iss1.art10
Diniwati Mukhtar, Aan Royhan, Hasna Luthfiah Fitriani, Melasari Marantika, Dita Safira Salsabila, Lena Fitriyana, Febri Irwansyah
Background: Obesity is one of the cardiovascular disease risk factors that cause hypertrophy or hyperplasia of adipocytes. Changes in fat cells have the potential to increase inflammation and insulin resistance. Objective: This study aims to determine the effects of high glucose, egg yolk consumption, calorie restriction, and air pollution on body weight, cell size, and fat tissue weight in rats. Methods: The type of study is experimental and conducted for six weeks. Thirty white male rats were divided into five groups: sugar-treated group, egg yolk-treated group, restricted calorie intake-treated group, air pollutant-treated group, and control group. The cell size and weight of adipose tissue were obtained from abdominal and supraclavicular fat samples.Results: High glucose, egg yolk consumption, air pollution exposure, and calorie restriction were affected by increases in body weight, cell size, and adipose tissue mass (p < 0.05). The cell size and weight of adipose tissue have a negative effect on body mass index. Nevertheless, dietary intervention studies have shown that the size of fat cells decreases after calorie restriction-induced weight loss. Conclusion: The body weight, cell size, and adipose tissue weight of the rats were affected by a high sugar intake, egg yolk consumption, calorie restriction, and exposure to air pollution.
{"title":"Effects of high glucose, egg yolk intake, calorie restriction, and air pollution on rats’ fat cell","authors":"Diniwati Mukhtar, Aan Royhan, Hasna Luthfiah Fitriani, Melasari Marantika, Dita Safira Salsabila, Lena Fitriyana, Febri Irwansyah","doi":"10.20885/jkki.vol14.iss1.art10","DOIUrl":"https://doi.org/10.20885/jkki.vol14.iss1.art10","url":null,"abstract":"Background: Obesity is one of the cardiovascular disease risk factors that cause hypertrophy or hyperplasia of adipocytes. Changes in fat cells have the potential to increase inflammation and insulin resistance. Objective: This study aims to determine the effects of high glucose, egg yolk consumption, calorie restriction, and air pollution on body weight, cell size, and fat tissue weight in rats. Methods: The type of study is experimental and conducted for six weeks. Thirty white male rats were divided into five groups: sugar-treated group, egg yolk-treated group, restricted calorie intake-treated group, air pollutant-treated group, and control group. The cell size and weight of adipose tissue were obtained from abdominal and supraclavicular fat samples.Results: High glucose, egg yolk consumption, air pollution exposure, and calorie restriction were affected by increases in body weight, cell size, and adipose tissue mass (p < 0.05). The cell size and weight of adipose tissue have a negative effect on body mass index. Nevertheless, dietary intervention studies have shown that the size of fat cells decreases after calorie restriction-induced weight loss. Conclusion: The body weight, cell size, and adipose tissue weight of the rats were affected by a high sugar intake, egg yolk consumption, calorie restriction, and exposure to air pollution.","PeriodicalId":32915,"journal":{"name":"JKKI Jurnal Kedokteran dan Kesehatan Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136048640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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