Arash Azhideh, Iman Menbari-Oskouie, Maryam Yousefi-Asl
In December 2019, the coronavirus ((COVID-19) outbreak related to severe acute respiratory syndrome (SARS-CoV2) originated in China and expanded exponentially as a public health pandemic to over 200 countries. Over 8 million validated cases and approximately 800 000 deaths. The main type is cardiac and respiratory but neurological symptoms are further mentioned as case series and case records in the research. The most frequent manifestations have been reported to include dizziness and headache followed by delirium and encephalopathy. Gillian barre syndrome, acute transversal myelitis, cerebrovascular accident, and encephalitis are among the complications noted. The most prominent occurrence at the periphery was hyposmia. This is also known that neurological demonstrations will also lead to regular features such as cough and fever, which evolve in these cases later on normal manifestations. For the timely diagnosis and separation of cases, therefore, a great suspicion guide is needed to arrest spread in neurology departments. This research provides a narrative study of COVID-19’s neurological symptoms and complexities. Our goal is to inform the neurologists and clinicians who work amidst potential COVID-19 patients regarding potential neurological symptoms, and likely neurological problems arising from the aforementioned new virus.
{"title":"Neurological Manifestation of COVID-19: A Literature Review","authors":"Arash Azhideh, Iman Menbari-Oskouie, Maryam Yousefi-Asl","doi":"10.34172/ICNJ.2020.20","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.20","url":null,"abstract":"In December 2019, the coronavirus ((COVID-19) outbreak related to severe acute respiratory syndrome (SARS-CoV2) originated in China and expanded exponentially as a public health pandemic to over 200 countries. Over 8 million validated cases and approximately 800 000 deaths. The main type is cardiac and respiratory but neurological symptoms are further mentioned as case series and case records in the research. The most frequent manifestations have been reported to include dizziness and headache followed by delirium and encephalopathy. Gillian barre syndrome, acute transversal myelitis, cerebrovascular accident, and encephalitis are among the complications noted. The most prominent occurrence at the periphery was hyposmia. This is also known that neurological demonstrations will also lead to regular features such as cough and fever, which evolve in these cases later on normal manifestations. For the timely diagnosis and separation of cases, therefore, a great suspicion guide is needed to arrest spread in neurology departments. This research provides a narrative study of COVID-19’s neurological symptoms and complexities. Our goal is to inform the neurologists and clinicians who work amidst potential COVID-19 patients regarding potential neurological symptoms, and likely neurological problems arising from the aforementioned new virus.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42621312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Al-Saadi, A. Alsharqi, Jawahir ALSharqi, Khadija ALBulushi, Asma A. Alrasbi, Maather Al-Farsi, Shamsa Al-Ghafri, S. Al-Abri, H. Al-Saadi
Background: Leaving against medical advice (LAMA) can be defined broadly as a patient’s insistence upon leaving the hospital against the treating team has expressed advice, which is both a challenge and concern for physicians, as these patients lost to follow-up, and their outcomes remain unknown. There is no previous study conducted to find the prevalence and causes of LAMA in brain tumors patients in the Middle East to the best of our knowledge.Methods: Patients studied in this research are those who were diagnosed with any type of brain tumors and were admitted to the Neurosurgical Department in Khoula Hospital (KH) but signed LAMA in the two years between January 2017 to December 2018 by going through the electronic medical records. Data obtained from the health information system includes socioeconomic characteristics, health status-related data, diagnosis-related data, and the reasons for LAMA.Results: A total number of 302 patients with brain tumors included in this study. Twenty-eight patients (9.2%) signed LAMA with a majority of those who signed LAMA were in the young adult’s group (3-39 years) and represented 18 (64%). Eight patients (28.57%) among the LAMA group and 43 patients (15.69%) in the non-LAMA group have tumors in the frontal lobe, which has found to be the most familiar location (29%). There was a significant relationship between the reason for LAMA and gender (P = 0.020).Conclusion: Younger patients, male, Omani, newly diagnosed tumors, and tumors in the frontal lobe were all risk factors for LAMA. Education and awareness about LAMA recommended in order to avoid readmission and loss of follow up.
{"title":"Leaving Against Medical Advice Among Patients With Brain Tumours in the Middle East: Khoula Hospital Experience","authors":"T. Al-Saadi, A. Alsharqi, Jawahir ALSharqi, Khadija ALBulushi, Asma A. Alrasbi, Maather Al-Farsi, Shamsa Al-Ghafri, S. Al-Abri, H. Al-Saadi","doi":"10.34172/ICNJ.2020.22","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.22","url":null,"abstract":"Background: Leaving against medical advice (LAMA) can be defined broadly as a patient’s insistence upon leaving the hospital against the treating team has expressed advice, which is both a challenge and concern for physicians, as these patients lost to follow-up, and their outcomes remain unknown. There is no previous study conducted to find the prevalence and causes of LAMA in brain tumors patients in the Middle East to the best of our knowledge.Methods: Patients studied in this research are those who were diagnosed with any type of brain tumors and were admitted to the Neurosurgical Department in Khoula Hospital (KH) but signed LAMA in the two years between January 2017 to December 2018 by going through the electronic medical records. Data obtained from the health information system includes socioeconomic characteristics, health status-related data, diagnosis-related data, and the reasons for LAMA.Results: A total number of 302 patients with brain tumors included in this study. Twenty-eight patients (9.2%) signed LAMA with a majority of those who signed LAMA were in the young adult’s group (3-39 years) and represented 18 (64%). Eight patients (28.57%) among the LAMA group and 43 patients (15.69%) in the non-LAMA group have tumors in the frontal lobe, which has found to be the most familiar location (29%). There was a significant relationship between the reason for LAMA and gender (P = 0.020).Conclusion: Younger patients, male, Omani, newly diagnosed tumors, and tumors in the frontal lobe were all risk factors for LAMA. Education and awareness about LAMA recommended in order to avoid readmission and loss of follow up.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43453315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashkan Divanbeigi, A. Seddighi, Sepideh Amiri, S. Jamshidi, Hesam Rahimi Baghdashti, Afsoon Seddighi
Background: Veterans with chronic spinal cord injury usually have various comorbidities. They are, therefore, visited by different doctors and use different medications. It is necessary to monitor the health of these veterans. One of the important issues in this regard is the attention to drug interactions. The purpose of this study was to investigate the drugs used and their interactions.Methods: This descriptive study of the cross-sectional studies was carried out retrospectively in 2015 under the Shefa Neuroscience Research Center’s supervision, examining the medical records of veterans with spinal cord injury participating in the health screening program at Khatam Alanbiya hospital in Tehran. Demographic data, comorbidities, used drugs, and the level of involvement collected. According to the FDA, drug interactions among the drugs used for each patient has evaluated and classified into three severe, moderate, and weak groups. SPSS v. 21 analyzed data.Results: The study population consisted of 404 men, ranging in age from 41 to 74, with a mean of 51.6 ± 6.4 years. One hundred forty-two of them (35.1%) had a complete injury, and 262 veterans (64.8%) had an incomplete injury. Only 17 veterans (4.2%) had no drug interactions. The number of drug interactions varied from 1 to 38, with an average of 5.9 ± 12.8 interactions per patient. The total number of interactions was 2856, of which 32.5% were weak, 55.3% moderate, and 12.2% severe, with a 95% confidence interval. Among the severe drug interactions in the study, the highest number belonged to the antidepressant drugs.Conclusion: This study highlights the necessity of developing a strategy for investigating and preventing drug interactions in veterans with chronic spinal cord injury. It has recommended that physicians pay more attention to other medications used by the patient and prescribe as little as possible of the drug and the drug with the least number of interactions.
背景:退伍军人慢性脊髓损伤通常有多种合并症。因此，他们被不同的医生拜访，使用不同的药物。有必要监测这些退伍军人的健康状况。这方面的一个重要问题是对药物相互作用的关注。本研究的目的是调查所使用的药物及其相互作用。方法:在Shefa神经科学研究中心的指导下，回顾性分析2015年在德黑兰Khatam Alanbiya医院参加健康筛查项目的脊髓损伤退伍军人的医疗记录，进行横断面研究的描述性研究。收集人口统计数据、合并症、使用药物和参与程度。根据FDA的规定，每个患者使用的药物之间的相互作用已经被评估并分为三个严重、中度和弱组。SPSS v. 21分析数据。结果:研究人群包括404名男性，年龄41 ~ 74岁，平均年龄51.6±6.4岁。其中完全性损伤142人(35.1%)，完全性损伤262人(64.8%)。只有17名退伍军人(4.2%)没有药物相互作用。药物相互作用次数为1 ~ 38次，平均每位患者发生5.9±12.8次相互作用。总交互次数为2856次，其中32.5%为弱交互，55.3%为中度交互，12.2%为重度交互，可信区间为95%。在研究中严重的药物相互作用中，抗抑郁药物的数量最多。结论:本研究强调了制定研究和预防慢性脊髓损伤退伍军人药物相互作用策略的必要性。它建议医生更多地关注患者使用的其他药物，并尽可能少地开这种药物和相互作用最少的药物。
{"title":"Drug Interactions in Iranian Veterans With Chronic Spinal Cord Injury - A Descriptive Study","authors":"Ashkan Divanbeigi, A. Seddighi, Sepideh Amiri, S. Jamshidi, Hesam Rahimi Baghdashti, Afsoon Seddighi","doi":"10.34172/ICNJ.2020.25","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.25","url":null,"abstract":"Background: Veterans with chronic spinal cord injury usually have various comorbidities. They are, therefore, visited by different doctors and use different medications. It is necessary to monitor the health of these veterans. One of the important issues in this regard is the attention to drug interactions. The purpose of this study was to investigate the drugs used and their interactions.Methods: This descriptive study of the cross-sectional studies was carried out retrospectively in 2015 under the Shefa Neuroscience Research Center’s supervision, examining the medical records of veterans with spinal cord injury participating in the health screening program at Khatam Alanbiya hospital in Tehran. Demographic data, comorbidities, used drugs, and the level of involvement collected. According to the FDA, drug interactions among the drugs used for each patient has evaluated and classified into three severe, moderate, and weak groups. SPSS v. 21 analyzed data.Results: The study population consisted of 404 men, ranging in age from 41 to 74, with a mean of 51.6 ± 6.4 years. One hundred forty-two of them (35.1%) had a complete injury, and 262 veterans (64.8%) had an incomplete injury. Only 17 veterans (4.2%) had no drug interactions. The number of drug interactions varied from 1 to 38, with an average of 5.9 ± 12.8 interactions per patient. The total number of interactions was 2856, of which 32.5% were weak, 55.3% moderate, and 12.2% severe, with a 95% confidence interval. Among the severe drug interactions in the study, the highest number belonged to the antidepressant drugs.Conclusion: This study highlights the necessity of developing a strategy for investigating and preventing drug interactions in veterans with chronic spinal cord injury. It has recommended that physicians pay more attention to other medications used by the patient and prescribe as little as possible of the drug and the drug with the least number of interactions.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41514705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stroke incidence of 0.9%-2% in especially young COVID-19 patients, is reported. The worst issue about this incidence is the high mortality rate despite even optimal treatment. Since the number of patients is as much as the World Health Organization (WHO) could declare the disease pandemic, it is important to review the pathophysiology in order to estimate the risk and guide the decision making. This letter aims to review the mechanism of virus pathophysiology and the following cerebrovascular presentations reported until now.
{"title":"Novel Coronavirus Characteristic Cerebrovasculopathic Effects","authors":"Sara Zandpazandi, M. Shahmohammadi","doi":"10.34172/ICNJ.2020.19","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.19","url":null,"abstract":"Stroke incidence of 0.9%-2% in especially young COVID-19 patients, is reported. The worst issue about this incidence is the high mortality rate despite even optimal treatment. Since the number of patients is as much as the World Health Organization (WHO) could declare the disease pandemic, it is important to review the pathophysiology in order to estimate the risk and guide the decision making. This letter aims to review the mechanism of virus pathophysiology and the following cerebrovascular presentations reported until now.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44769342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jignesh Dhirubhai Dhameliya, U. Chandra, S. Vishwakarma, Dattaprasad Ganganpalli, A. Verma
Background: It is suggested that there is a positive association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV). We suggest, as a hypothesis, there is a positive association between vitamin D deficiency and BPPV. The current study aimed to investigate the association between vitamin D levels and BPPV.Methods: The present observational case-control study was planned and conducted on 100 participants (50 cases and 50 controls) in the Department of Neurology, Choithram Hospital & Research Center (CHRC), Indore, MP, India, from January 2018 to December 2018. All consecutive patients with diagnosis of idiopathic BPPV who were above the age of 18 years with a negative neurological status were included. Analyses were performed using SPSS software version 10. Results: BPPV was more common among those aged 50 to 70 years (64%). Out of 100 participants, 72 (72%) had vitamin D deficiency, in which 40 (80%) were cases and 32 (64%) were controls. 32 (64%) patients had posterior canal involved, out of them 20 (40%) were females and 12 (24%) were males, and in both groups posterior canal was more involved. Canal involvement according to gender was not statistically significant (P value=0.45). Mean vitamin D level for cases and controls was 34.9 and 46.5 nmol/L, respectively, and this difference was statically very significant with a p-value of 0.01 (P value < 0.05).Conclusion: According to the findings, there is a statistically significant association between vitamin D3 deficiency and Idiopathic BPPV. It can be noted that vitamin D3 deficiency may be a risk factor for the BPPV.
{"title":"Investigating the Association Between Serum Vitamin D Deficiency and Idiopathic Benign Paroxysmal Positional Vertigo","authors":"Jignesh Dhirubhai Dhameliya, U. Chandra, S. Vishwakarma, Dattaprasad Ganganpalli, A. Verma","doi":"10.34172/icnj.2020.12","DOIUrl":"https://doi.org/10.34172/icnj.2020.12","url":null,"abstract":"Background: It is suggested that there is a positive association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV). We suggest, as a hypothesis, there is a positive association between vitamin D deficiency and BPPV. The current study aimed to investigate the association between vitamin D levels and BPPV.Methods: The present observational case-control study was planned and conducted on 100 participants (50 cases and 50 controls) in the Department of Neurology, Choithram Hospital & Research Center (CHRC), Indore, MP, India, from January 2018 to December 2018. All consecutive patients with diagnosis of idiopathic BPPV who were above the age of 18 years with a negative neurological status were included. Analyses were performed using SPSS software version 10. Results: BPPV was more common among those aged 50 to 70 years (64%). Out of 100 participants, 72 (72%) had vitamin D deficiency, in which 40 (80%) were cases and 32 (64%) were controls. 32 (64%) patients had posterior canal involved, out of them 20 (40%) were females and 12 (24%) were males, and in both groups posterior canal was more involved. Canal involvement according to gender was not statistically significant (P value=0.45). Mean vitamin D level for cases and controls was 34.9 and 46.5 nmol/L, respectively, and this difference was statically very significant with a p-value of 0.01 (P value < 0.05).Conclusion: According to the findings, there is a statistically significant association between vitamin D3 deficiency and Idiopathic BPPV. It can be noted that vitamin D3 deficiency may be a risk factor for the BPPV.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"122-126"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41992985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Ashrafi, A. Rezaei, Arash Azhideh, F. Tabeie, L. Gachkar, M. Ahmadi, Maryam Yousefi-Asl, A. Zali, R. Khoshnoud
Introduction: Stroke is one of the most devastating neurologic conditions in the world. Despite all the efforts that have been made for effective treatment, the prevalence of this medical condition is still high. One of the new methods in the treatment of patients is the use of low power laser and pulsed magnetic fields. The previous studies investigated the effectiveness of these methods individually. However, the present study aimed to investigate their effectiveness in combination.Methods: We divided the patients into control (n = 26) and experimental (n=26) groups. The primary variables included the Mini-Mental State Examination (MMSE) and the National Institute of Health Stroke Scale (NIHSS). The experimental group received Extremely Low-Frequency Electromagnetic Field (EMF-ELF) treatment with 1 mT power and laser in rejection with a wavelength of 840 nm for 5 days and 45 minutes per day. Results: The variable measured during this study, in addition to comparing the results of the intervention between the control and experimental groups, showed a significant difference in all indicators before and after the intervention. The mean and standard deviations of the Modified Rankin Scale (mRS), functional status (Barthel’s index), and cognitive status (MMSE) (p<0.001) were signed between two groups.Conclusion: Laser and magnetic field combination can be effective in the treatment of stroke. Further studies are recommended to ensure a better comparison.Keywords: Stroke; Low Level Light Therapy; Electromagnetic Field; Nonablative Laser Treatments
{"title":"Effectiveness of Extremely Low Frequency Electromagnetic Field and Pulsed Low Level Laser Therapy in Acute Stroke Treatment","authors":"F. Ashrafi, A. Rezaei, Arash Azhideh, F. Tabeie, L. Gachkar, M. Ahmadi, Maryam Yousefi-Asl, A. Zali, R. Khoshnoud","doi":"10.34172/icnj.2020.13","DOIUrl":"https://doi.org/10.34172/icnj.2020.13","url":null,"abstract":"Introduction: Stroke is one of the most devastating neurologic conditions in the world. Despite all the efforts that have been made for effective treatment, the prevalence of this medical condition is still high. One of the new methods in the treatment of patients is the use of low power laser and pulsed magnetic fields. The previous studies investigated the effectiveness of these methods individually. However, the present study aimed to investigate their effectiveness in combination.Methods: We divided the patients into control (n = 26) and experimental (n=26) groups. The primary variables included the Mini-Mental State Examination (MMSE) and the National Institute of Health Stroke Scale (NIHSS). The experimental group received Extremely Low-Frequency Electromagnetic Field (EMF-ELF) treatment with 1 mT power and laser in rejection with a wavelength of 840 nm for 5 days and 45 minutes per day. Results: The variable measured during this study, in addition to comparing the results of the intervention between the control and experimental groups, showed a significant difference in all indicators before and after the intervention. The mean and standard deviations of the Modified Rankin Scale (mRS), functional status (Barthel’s index), and cognitive status (MMSE) (p<0.001) were signed between two groups.Conclusion: Laser and magnetic field combination can be effective in the treatment of stroke. Further studies are recommended to ensure a better comparison.Keywords: Stroke; Low Level Light Therapy; Electromagnetic Field; Nonablative Laser Treatments","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"127-131"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43792136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sepideh Paybast, Fatemeh Baghalha, A. Emami, Mohsen Koosha
Background: The outbreak of the novel coronavirus disease (COVID-19) imposes a considerable psychological burden on the medical staff working in central hospitals for COVID-19. In this systematic review, we will discuss the prevalence and the risk factors of anxiety disorder among the frontline medical staff dealing with COVID-19 patients.Methods: PubMed, Scopus, Embase, Web of Science data bases were systematically searched from December 01, 2019 to April 30, 2020 for related published articles. In all electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: “COVID-19” OR “novel Coronavirus” AND “anxiety” OR “psychology” OR “psychiatry” OR “psychological distress” AND “nurses” or “clinicians”. We included only the cross sectional studies.Results: Through the search strategy, we could identify eight related cross sectional articles about anxiety among the healthcare workers in central hospitals for COVID-19 infection. However, the authors scanned the reference lists of the included studies and identified multiple references. According to our findings, the frontline medical staff are at risk developing anxiety disorder which is mainly mild. Additionally, the female nurses are more susceptible to experience anxiety during the COVID-19 pandemic.Conclusion: Regarding to the outbreak of COVID-19 worldwide and the workload of the frontline medical staff dealing with COVID-19 patients, a particular attention should be given on the mental health of the healthcare provides.
背景：新型冠状病毒病（新冠肺炎）的爆发给新冠肺炎中心医院的医护人员带来了巨大的心理负担。在这篇系统综述中，我们将讨论新冠肺炎患者的一线医务人员中焦虑症的患病率和危险因素。方法：从2019年12月1日至2020年4月30日，系统检索PubMed、Scopus、Embase、Web of Science数据库中的相关发表文章。在所有电子数据库中，实施了以下搜索策略，并使用了这些关键词（标题/摘要）：“新冠肺炎”或“新型冠状病毒”与“焦虑”或“心理学”或“精神病学”或“心理困扰”与“护士”或“临床医生”。我们只包括横断面研究。结果：通过搜索策略，我们可以识别出8篇关于新冠肺炎感染中心医院医护人员焦虑的相关横断面文章。然而，作者扫描了纳入研究的参考文献列表，并确定了多个参考文献。根据我们的研究结果，一线医务人员有患焦虑症的风险，焦虑症主要是轻度的。此外，在新冠肺炎大流行期间，女护士更容易感到焦虑。结论：鉴于新冠肺炎疫情在全球范围内的爆发以及一线医护人员处理新冠肺炎患者的工作量，应特别关注医护人员的心理健康。
{"title":"The Anxiety Disorder Among the Healthcare Providers During The COVID-19 Infection Pandemic: A Systematic Review","authors":"Sepideh Paybast, Fatemeh Baghalha, A. Emami, Mohsen Koosha","doi":"10.34172/icnj.2020.11","DOIUrl":"https://doi.org/10.34172/icnj.2020.11","url":null,"abstract":"Background: The outbreak of the novel coronavirus disease (COVID-19) imposes a considerable psychological burden on the medical staff working in central hospitals for COVID-19. In this systematic review, we will discuss the prevalence and the risk factors of anxiety disorder among the frontline medical staff dealing with COVID-19 patients.Methods: PubMed, Scopus, Embase, Web of Science data bases were systematically searched from December 01, 2019 to April 30, 2020 for related published articles. In all electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: “COVID-19” OR “novel Coronavirus” AND “anxiety” OR “psychology” OR “psychiatry” OR “psychological distress” AND “nurses” or “clinicians”. We included only the cross sectional studies.Results: Through the search strategy, we could identify eight related cross sectional articles about anxiety among the healthcare workers in central hospitals for COVID-19 infection. However, the authors scanned the reference lists of the included studies and identified multiple references. According to our findings, the frontline medical staff are at risk developing anxiety disorder which is mainly mild. Additionally, the female nurses are more susceptible to experience anxiety during the COVID-19 pandemic.Conclusion: Regarding to the outbreak of COVID-19 worldwide and the workload of the frontline medical staff dealing with COVID-19 patients, a particular attention should be given on the mental health of the healthcare provides.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The novel coronavirus (COVID-19) is a global pandemic. Although the main clinical manifestations of the COVID-19 infection has confined to the respiratory system, there is some evidence suggesting the neuro-invasive potential of the COVID-19. There are limited reports of Guillain–Barre syndrome (GBS) as a peripheral nervous system complication of COVID-19 infection.Methods and results: We described four patients with COVID-19 infection who developed acute polyneuropathy with a final diagnosis of Guillain–Barre syndrome.Conclusion: COVID-19 may have the potential to invade the peripheral nervous system. GBS, as one of the critical neurological complications of COVID-19, could be considered as a post-infectious event.
{"title":"Guillain-Barre syndrome as a neurological complication of COVID-19 infection: a case series and review of the literature","authors":"H. Mozhdehipanah, Sepideh Paybast, R. Gorji","doi":"10.34172/icnj.2020.18","DOIUrl":"https://doi.org/10.34172/icnj.2020.18","url":null,"abstract":"Background: The novel coronavirus (COVID-19) is a global pandemic. Although the main clinical manifestations of the COVID-19 infection has confined to the respiratory system, there is some evidence suggesting the neuro-invasive potential of the COVID-19. There are limited reports of Guillain–Barre syndrome (GBS) as a peripheral nervous system complication of COVID-19 infection.Methods and results: We described four patients with COVID-19 infection who developed acute polyneuropathy with a final diagnosis of Guillain–Barre syndrome.Conclusion: COVID-19 may have the potential to invade the peripheral nervous system. GBS, as one of the critical neurological complications of COVID-19, could be considered as a post-infectious event.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45338657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Farhadi, S. Moniri, M. Jameie, Nasrin Hosseini, M. Jameie, S. B. Jameie
Background: Glioblastoma multiforme (GBM) is the most type of brain malignancy in adults. Radical excision surgery, chemotherapy, and radiotherapy in some cases are still unsuccessful, and most patients with GBM die within three to six months following diagnosis. Botulinum toxin type A (BtxA) has cellular toxin effects and suppresses the cell division of certain types of cancer cell lines in vivo and in vitro study. The present study designed to evaluate the apoptotic effect of BtxA on the GBM cell line.Material & methods: U87-MG GBM cell line cultured according to the routing protocols, divided into two groups including, trial (BtxA treated) and control groups. Cells of the trial group exposed to different doses of BtxA. The cell viability, cycle arrest, and pro-apoptotic proteins evaluated respectively by MTT assay, SubG1, and Western blotting.Results: MTT assay showed that the viability of the BtxA treated cells at doses of 1.45 Unit and other doses after 24 to 48 hours, significantly decreased (p<0.001) compared to the control groups. Apoptosis percentage of the SubG1 test also indicated that 1.45 Unit dose significantly increased in the cells exposed to BtxA compared to the control group in 24 hours. The expression of P53 and Caspase 3 proteins indicated a significant increase.Conclusion: BtxA induces apoptosis in U87- MG cell line via p53 and caspase three pathways and could have clinical applications. In vivo studies need to confirm the clinical application of the present findings.
{"title":"Expression of the Apoptotic Proteins in Glioblastoma U87-MG Cell Line Treated by Botulinum Toxin","authors":"M. Farhadi, S. Moniri, M. Jameie, Nasrin Hosseini, M. Jameie, S. B. Jameie","doi":"10.34172/icnj.2020.14","DOIUrl":"https://doi.org/10.34172/icnj.2020.14","url":null,"abstract":"Background: Glioblastoma multiforme (GBM) is the most type of brain malignancy in adults. Radical excision surgery, chemotherapy, and radiotherapy in some cases are still unsuccessful, and most patients with GBM die within three to six months following diagnosis. Botulinum toxin type A (BtxA) has cellular toxin effects and suppresses the cell division of certain types of cancer cell lines in vivo and in vitro study. The present study designed to evaluate the apoptotic effect of BtxA on the GBM cell line.Material & methods: U87-MG GBM cell line cultured according to the routing protocols, divided into two groups including, trial (BtxA treated) and control groups. Cells of the trial group exposed to different doses of BtxA. The cell viability, cycle arrest, and pro-apoptotic proteins evaluated respectively by MTT assay, SubG1, and Western blotting.Results: MTT assay showed that the viability of the BtxA treated cells at doses of 1.45 Unit and other doses after 24 to 48 hours, significantly decreased (p<0.001) compared to the control groups. Apoptosis percentage of the SubG1 test also indicated that 1.45 Unit dose significantly increased in the cells exposed to BtxA compared to the control group in 24 hours. The expression of P53 and Caspase 3 proteins indicated a significant increase.Conclusion: BtxA induces apoptosis in U87- MG cell line via p53 and caspase three pathways and could have clinical applications. In vivo studies need to confirm the clinical application of the present findings.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"132-137"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48551067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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