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Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference最新文献

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Resorbable chitosan matrix-a promising biomaterial for the future 可吸收壳聚糖基质——一种很有前途的生物材料
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514502
T. Chandy, C. P. Sharma
Chitosan, a natural polysaccharide, having structural characteristics similar to glycosaminoglycans seems to be non-toxic and bioadsorbable. The chitosan matrix has been extensively investigated in the author's laboratory for a variety of biomedical applications, such as the removal of bilirubin, haemodialysis membranes, for delivery of drugs, charcoal encapsulated chitosan beads (ACCB) for toxin removal, specific immunoadsorbent matrix, chitosan coated hydroxyapatite as orthopaedic and dental dialysis materials etc. Thus, chitosan is a viable material, which can be fabricated into various forms, such as beads, granules tablets, membranes etc, as per requirements. With all these variety of biomedical uses, it appears, chitosan may be a future promise for anchoring the tissue interfaces. This paper highlights the importance of this novel matrix for such biomedical applications.
壳聚糖是一种天然多糖,具有与糖胺聚糖相似的结构特征,似乎是无毒的和可生物吸附的。壳聚糖基质在生物医学上的广泛应用,如去除胆红素、血液透析膜、药物输送、木炭包封壳聚糖珠(ACCB)去除毒素、特异性免疫吸附基质、壳聚糖包覆羟基磷灰石作为骨科和牙科透析材料等。因此,壳聚糖是一种可行的材料,它可以根据需要制成各种形式,如珠状、颗粒状、片状、膜状等。有了这些生物医学上的用途,壳聚糖似乎是未来固定组织界面的一个希望。本文强调了这种新型基质在此类生物医学应用中的重要性。
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引用次数: 4
Three-dimensional finite element modeling of the horse's foot 马脚的三维有限元建模
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514432
J. Hanft, H. Hogan, D. Hood
A procedure for creating a three-dimensional finite element model of a horse's foot is presented. This procedure is applicable to a variety of complex biological structures including joints.
提出了一种建立马蹄三维有限元模型的方法。该程序适用于包括关节在内的各种复杂生物结构。
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引用次数: 3
Biomechanics of bone-ligament-bone units for reconstruction of the scapholunate 舟月骨重建中骨-韧带-骨单元的生物力学
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514447
S. Moeini, W. Perry, J.R. Tamarapalli, J. Lemons, M. J. Wilkins, R. Meyer
A proposed alternative to existing "suboptimal" therapies or fusion available for the treatment of scapholunate dissociation is its replacement with a bone-ligament-bone unit transferred from the ankle. The objective of this study was to evaluate the biomechanical properties of ankle ligaments compared to wrist ligaments for their potentials as a bone-ligament-bone replacement. Based upon the mechanical strength and strain properties displayed by the ankle ligaments tested, a good biomechanical rationale exists for transferring either the anterior talofibular or anterior tibiofibular ligament for the clinical replacement of the scapholunate ligament.
替代现有的“次优”治疗或融合治疗舟月骨分离的建议是用从踝关节转移的骨-韧带-骨单元代替舟月骨。本研究的目的是评估踝关节韧带与腕关节韧带作为骨-韧带-骨替代物的生物力学特性。根据踝关节韧带测试显示的机械强度和应变特性,有一个很好的生物力学基础存在于转移距腓骨前韧带或胫腓骨前韧带用于临床替代舟月骨韧带。
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引用次数: 0
Pressure-volume studies in human lumbar spinal discs 人腰椎间盘压力-容积研究
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514496
H. Ranu
A continuous pressure-volume relation is determined within the nucleus pulposus of the human spinal disc by infusing saline solution. The data show that the nucleus pulposus has the properties of a tight hydraulic space in which a large pressure rise results from a small increase in volume and the opposite is also true.
通过注入生理盐水溶液,确定了人椎间盘髓核内连续的压力-体积关系。结果表明,髓核具有紧致的水力空间特性,即体积小而压力大,反之亦然。
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引用次数: 4
Development of a doctoral program in health care sciences 卫生保健科学博士课程的发展
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514500
H. Ranu
The doctoral degree is an innovative development in the American health care arena and offers the opportunity to investigate health care within the national and interdisciplinary context. The study of health care requires an awareness of new forms of information and ability to synthesize material from a wide range of disciplines and to communicate outcomes. This program is designed to meet the objective of healthy people for the year 2000 and beyond. Topics discussed include admission requirements, criteria for student intake, core courses, elective courses and career opportunities.
博士学位是美国医疗保健领域的一个创新发展,并提供了在国家和跨学科背景下调查医疗保健的机会。卫生保健的研究需要对信息的新形式的认识,以及从广泛的学科中综合材料和交流结果的能力。该方案旨在实现2000年及以后健康人民的目标。讨论的主题包括入学要求、学生入学标准、核心课程、选修课程和就业机会。
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引用次数: 0
Development and clinical application of artificial bone and bioactive bone cement in Japan 日本人工骨和生物活性骨水泥的开发与临床应用
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514457
T. Yamamuro
Summary form only given. Apatite- and wollastonite-containing glass-ceramic (AG-GC) was synthesized in 1981 at Kyoto University, Japan to be used as a strong and bone-bonding artificial bone. It is a hybrid material consisting of three phases of apatite, wollastonite, and glass with a chemical composition of MgO 4.6, CaO 44.9, SiO/sub 2/ 34.2, P/sub 2/O/sub 5/ 16,3, CaF/sub 2/ 8.5 in weight ratio. Its compressive strength, bending strength and elastic modulus are higher than those of human cortical bone. It has excellent biocompatibility and became firmly bonded directly with bone by 8 weeks when it was implanted into the tibia of a rabbit or fixed on the surface of the cortex of a rabbit tibia. After obtaining favorable results in animal experiments where vertebral prostheses made of AW-GC were used to replace the lumbar vertebra of sheep, the authors prepared an AW-GC made vertebral prosthesis for clinical use in 1983. Since then, the vertebral prosthesis has been used in 1,070 clinical cases to replace vertebrae which were affected by malignant tumors, burst fracture, compression fracture, and fracture dislocation. The prosthesis was firmly fixed to the adjacent bone with either Zielke's instruments or a Kaneda device anteriorly, and if necessary, in combination with either Luque or Harrington rods posteriorly. The authors have not experienced, up to the present, dislocation, loosening, or breakage of the prosthesis. In 1987 the authors prepared an iliac crest prosthesis, a laminoplasty spacer, and a granular bone filler made of AW-GC. Since then, the iliac crest prosthesis has been used in 4,113 clinical cases to restore the shape of the iliac crest after harvesting a large bone graft from it. Patient satisfaction regarding appearance of the crest, pain, and foreign body feeling was excellent in 97% of the patients after two years postoperatively. New bone formation around the prosthesis progressed steadily, and one year after the operation, good new bone formation was observed in 90% of the patients.
只提供摘要形式。含磷灰石和硅灰石的玻璃陶瓷(AG-GC)于1981年在日本京都大学合成,用于强骨粘合人工骨。它是一种由磷灰石、硅灰石和玻璃三相组成的杂化材料,化学成分的重量比为MgO 4.6、CaO 44.9、SiO/sub 2/ 34.2、P/sub 2/O/sub 5/ 16.3、CaF/sub 2/ 8.5。其抗压强度、抗弯强度和弹性模量均高于人类皮质骨。将其植入兔胫骨或固定在兔胫骨皮质表面,8周后与骨直接牢固结合,具有良好的生物相容性。在动物实验中,利用awa - gc制作的椎体假体替代绵羊腰椎,取得了良好的效果。1983年,作者制作了一种awa - gc制作的椎体假体用于临床。此后,临床应用椎体假体置换恶性肿瘤、爆裂性骨折、压缩性骨折、骨折脱位等椎体病例1070例。假体在前面用Zielke的器械或Kaneda装置牢固地固定在相邻的骨头上,必要时在后面结合Luque或Harrington棒。到目前为止,作者还没有经历过假体脱位、松动或断裂。1987年,作者制备了一个髂骨假体、一个椎板成形术间隔器和一个由AW-GC制成的颗粒状骨填充物。从那时起,髂骨假体已经在4113例临床病例中使用,在从髂骨上收获大块骨移植后恢复了髂骨的形状。术后两年后,97%的患者对嵴外观、疼痛和异物感满意。假体周围新骨形成进展平稳,术后1年90%的患者新骨形成良好。
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引用次数: 0
An investigation into the role of iliac artery distensibility in balloon angioplasty 髂动脉扩张在球囊血管成形术中的作用探讨
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514482
N. F. MacLean, R. Rankin, M. Sherebrin, A. Fenster, M. R. Roach
Angioplasty is a common and successful technique for reopening stenosed arteries to blood flow. In spite of this achievement, a large number of patients restenose the site of angioplasty within only 6 months of the procedure. Clearly, the patient's response to angioplasty is not consistent but instead, appears to be unpredictable. Although angioplasty is often chosen over surgery, the mechanism by which angioplasty achieves luminal enlargement is not completely understood. The authors believe that the most important parameters that determines the response of a stenosed artery are the elastic properties of the artery and the composition of the plaque. Here, the authors examined the response of 4 isolated human common iliac arteries to balloon angioplasty. Aorto-iliac branches were harvested at autopsy from patients aged between 39 and 60 years. The specimens were cleaned of adipose tissue and were made pressure tight by tying-off side branches. The bifurcations were mounted in a high-resolution laboratory computed tomographic (CT) scanner and were studied at luminal pressures ranging from 8 to 24 kPa. Humidified air was used to pressurize the lumen because it kept the arteries moist during the experiment. Common iliac artery distensibility was measured from 2-dimensional (2D) cross-sectional slices obtained at seven pressures both pre- and post-angioplasty. The diameter of the balloon was chosen to be 1.2/spl times/the diameter of the normal common iliac diameter. Following the acquisition of the 2D images, a 3-dimensional volume image was obtained at a luminal pressure of 13.3 kPa. The authors found a considerable change in the mechanical properties of the iliac arteries they have studied. Luminal cross-sectional area increased linearly with arterial pressure prior to angioplasty but became nonlinear following angioplasty. The variation in area with pressure was shown to have 2 components: an initial linear increase at low pressure followed by a plateau at higher pressures. Distensibility was calculated from the slopes of the luminal perimeter versus pressure graphs and were found to be linear pre-angioplasty, but nonlinear post-angioplasty. The authors speculate that angioplasty increases luminal area by tearing elastin sheets but this remains to be proven.
血管成形术是一种常见且成功的技术,用于重新开放狭窄的动脉以供血液流动。尽管取得了这一成就,但大量患者在手术后仅6个月内血管成形术部位再狭窄。显然,患者对血管成形术的反应是不一致的,相反,似乎是不可预测的。虽然血管成形术通常比手术更受欢迎,但血管成形术实现腔内扩大的机制尚不完全清楚。作者认为,决定狭窄动脉反应的最重要参数是动脉的弹性特性和斑块的组成。在这里,作者检查了4个离体人髂总动脉对球囊血管成形术的反应。主动脉-髂分支在解剖时从年龄在39至60岁之间的患者身上采集。标本被清除脂肪组织,并通过捆绑侧枝使其压紧。分叉安装在高分辨率实验室计算机断层扫描(CT)扫描仪上,并在8至24千帕的管压范围内进行研究。加湿的空气被用来给管腔加压,因为它在实验中保持动脉湿润。通过在血管成形术前和成形术后7种压力下获得的二维(2D)横切面测量髂总动脉的扩张。球囊直径选择为正常髂总直径的1.2/spl倍。在获得二维图像后,在13.3 kPa的管压下获得三维体积图像。作者发现他们所研究的髂动脉的力学特性发生了相当大的变化。血管成形术前管腔截面积随动脉压力线性增加,但血管成形术后变为非线性。面积随压力的变化有两个组成部分:低压时初始线性增加,高压时趋于平稳。从管腔周长与压力图的斜率计算膨胀率,发现血管成形术前是线性的,但血管成形术后是非线性的。作者推测血管成形术通过撕裂弹性蛋白片来增加管腔面积,但这还有待证实。
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引用次数: 0
Oxidation level changes in radiation sterilized ultra high molecular weight polyethylene [medical implant material application] 辐射灭菌超高分子量聚乙烯氧化水平变化[医用植入材料应用]
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514440
S. Phillips, A. Puckett, A. McKie
Summary form only received as follows: The objective of this study was to monitor the change in oxidation levels of radiation sterilized ultra high molecular weight polyethylene (UHMWPE) with time. Specimens of UHMWPE were packaged in air and sterilized at 2.5 megarads or 3.7 megarads using a commercial cycle. Control specimens from the same lot of material which were not sterilized were monitored over the same time period. Each sample was sectioned upon receipt to produce three 100 /spl mu/m thick specimens which were characterized using Fourier transform infrared (FTIR) microscopy. Spectra were collected at 100 /spl mu/m increments using a vernier stage and adjustable slit aperture. The initial surface oxidation levels were 300% greater than control samples for both radiation levels. After 12 months of storage, additional samples were prepared and examined. Samples irradiated at 3.7 megarads in air showed an additional 500% increase in surface oxidation which extended 200 /spl mu/m into the material. For the sample irradiated at 2.5 megarads a 300% additional increase in oxidation level was found on the surface but the oxidation level was only 170% greater at 200 /spl mu/m. These results suggest that radiation sterilized UHMWPE undergoes significant increases during storage. Oxidation of radiation sterilized UHMWPE implants may have a significant impact on the bearing properties of these materials.
摘要:本研究的目的是监测辐射灭菌超高分子量聚乙烯(UHMWPE)氧化水平随时间的变化。超高分子量聚乙烯标本在空气中包装,并使用商业循环在2.5兆加仑或3.7兆加仑灭菌。同一批次未灭菌材料的对照标本在同一时间段内进行监测。每个样品在收到后切片,产生三个100 /spl mu/m厚的样品,使用傅里叶变换红外(FTIR)显微镜进行表征。采用游标平台和可调狭缝孔径,以100 /spl μ m的增量采集光谱。在两种辐射水平下,初始表面氧化水平都比对照样品高300%。储存12个月后,准备并检查额外的样品。样品在空气中辐照3.7兆加仑时,表面氧化增加500%,向材料中扩展200 /spl μ l /m。在2.5 μ g辐照下,样品表面氧化水平增加了300%,而在200 μ g / m2辐照下,氧化水平仅增加了170%。这些结果表明,辐射灭菌的超高分子量聚乙烯在储存过程中会显著增加。辐射灭菌的超高分子量聚乙烯植入物的氧化可能对这些材料的承载性能产生重大影响。
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引用次数: 0
Polyethylene contact stress and knee condylar design 聚乙烯接触应力和膝关节髁设计
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514497
G. Miller, C. Goll, W. Soscia, W. Petty, V. Choudry
Successful reconstruction of the knee involves appropriate patient selection, implant design, implant material and surgical technique. Although the performance and longevity of these arthroplasties continues to improve, their performance is not as long-lasting as we have come to expect from total hip arthroplasty. The work reported in this study depicts the preliminary results of the effect of femoral component varus/valgus position and flexion position using a real-time computerized pressure mapping system (TekScan) for three designs with different geometric congruities.
成功的膝关节重建包括合适的患者选择、植入物设计、植入物材料和手术技术。尽管这些人工髋关节的性能和寿命都在不断提高,但它们的性能并不像我们所期望的全髋关节置换术那样持久。本研究报告的工作描述了使用实时计算机压力测绘系统(TekScan)对三种不同几何一致性设计的股骨内翻/外翻位置和屈曲位置影响的初步结果。
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引用次数: 1
Dynamic three-dimensional in vivo tracking of the abnormal extensor mechanism 异常伸肌机制的动态三维体内跟踪
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514448
P. Christakis, L.S. Popich, S. Cook, M. E. Brunet
This study addresses the effects of extensor mechanism realignment (EMR) on patellar tracking patterns in pathologic knees. Ten patients diagnosed with patellar maltracking, subluxation, or patellofemoral malalignment and requiring an EMR participated in the study. Lateral release and vastus medialis obliquus (VMO) advancement were performed unilaterally in all ten patients. Tibial tubercle transfer was conducted in five of these patients. Electromagnetic sensors were used to dynamically measure patellar and tibial motion relative to the femur in three dimensions. Patella flexion, rotation, tilt, and shift were measured as the knee was passively flexed from full extension to 90/spl deg/ knee flexion. Lateral release had little effect on patellar spin and flexion patterns, although it did increase net medial shift in seven of ten cases. Following VMO advancement the rate of patellar flexion and net medial patellar spin increased in seven cases. Net lateral patellar tilt increased in seven cases and medial shift increased in five cases. Due to a limited amount of data, conclusive observations could not be made regarding tibial tubercle transfer.
本研究探讨了伸肌机制调整(EMR)对病理性膝关节髌骨追踪模式的影响。10名被诊断为髌骨错位、半脱位或髌骨股骨错位并需要EMR的患者参与了这项研究。所有10例患者均单侧进行外侧松解和股内侧斜肌(VMO)推进。其中5例患者行胫骨结节转移术。电磁传感器用于动态测量髌骨和胫骨相对于股骨的三维运动。当膝关节从完全伸展被动屈曲至90/spl度/膝关节屈曲时,测量髌骨屈曲、旋转、倾斜和移位。侧松解对髌骨旋转和屈曲模式影响不大,尽管在10例中有7例确实增加了净内侧移位。在VMO推进后,7例髌骨屈曲率和髌骨内侧净旋率增加。净外侧髌骨倾斜增加7例,内侧移位增加5例。由于数据量有限,无法对胫骨结节转移进行结论性观察。
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引用次数: 0
期刊
Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference
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