Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514431
B. Lurate, D. P. Mukherjee, R. N. Kruse, J. Albright
Smaller osteschondral fragments containing little or no cortex present difficult treatment dilemma. Metallic screws or Kirschner wires often require subsequent removal either as part of the original operative plan or because of problems such as loosening and/or cartilage erosion. An attractive alternative would be a biodegradable implant that would transfix an osteochondral fragment with minimal violation of the articular surface. The objectives of this study are (1) to compare osteochondral fracture fixation of 2mm polyglycolic acid (PGA) absorbable pins (Acufex, Manfield, Mass) with that of Kirschner wires (K-wires) in cadavers, (2) to review patient data where osteochondral fractures were fixed with PGA-pins. The following conclusions were obtained: (1) Cadaver Studies: The biomechanical parameters of the osteochondral fractures fixed with absorbable PGA pins were not statistically different from those fixed with K-wires. Based on these laboratory studies it appears that fixation of osteochondral fractures with bioabsorbable PGA pins may offer a viable alternative to the use of K-wires. (2) Clinical Cases: A short follow up period with four clinical cases indicated that in carefully selected injuries, fixation with absorbable pins could become the treatment of choice of smaller joints. For severely comminuted fractures about major joints, PGA absorbable pins may be an adjunct to metal fixation.
{"title":"Fixation of osteochondral fractures with absorbable pins","authors":"B. Lurate, D. P. Mukherjee, R. N. Kruse, J. Albright","doi":"10.1109/SBEC.1995.514431","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514431","url":null,"abstract":"Smaller osteschondral fragments containing little or no cortex present difficult treatment dilemma. Metallic screws or Kirschner wires often require subsequent removal either as part of the original operative plan or because of problems such as loosening and/or cartilage erosion. An attractive alternative would be a biodegradable implant that would transfix an osteochondral fragment with minimal violation of the articular surface. The objectives of this study are (1) to compare osteochondral fracture fixation of 2mm polyglycolic acid (PGA) absorbable pins (Acufex, Manfield, Mass) with that of Kirschner wires (K-wires) in cadavers, (2) to review patient data where osteochondral fractures were fixed with PGA-pins. The following conclusions were obtained: (1) Cadaver Studies: The biomechanical parameters of the osteochondral fractures fixed with absorbable PGA pins were not statistically different from those fixed with K-wires. Based on these laboratory studies it appears that fixation of osteochondral fractures with bioabsorbable PGA pins may offer a viable alternative to the use of K-wires. (2) Clinical Cases: A short follow up period with four clinical cases indicated that in carefully selected injuries, fixation with absorbable pins could become the treatment of choice of smaller joints. For severely comminuted fractures about major joints, PGA absorbable pins may be an adjunct to metal fixation.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123805884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514507
J.R. Tamarapalli, J. Lemons, J. Dockery, B. Burdick
The major main aims of the study were to: 1. develop a device to obtain a better result compared to manual puncture site compression; 2. develop a stable device which would not slip during application; 3. help all dialysis patients, especially those patients who are unable to hold their needle puncture sites; 4. relieve the nurse to attend to other activities; and 5. to better utilize the whole length of the graft thereby preventing recirculation of non-dialysis blood and repeatedly puncturing a short length of the graft. A device was fabricated from a light weight plastic material with a C shape. This contour allowed conformity to the various shapes of the dialysis access limbs. The device included a rotatable threaded shaft, with which it was possible to achieve a controlled pressure on the fistula or graft. An internal (shaft) safety mechanism was incorporated so that undue pressure could not be applied on the vascular graft. The device was designed to be stable and comfortable. The puncture site contact surface of the device was designed to be disposable and to minimize any possibilities of cross contamination. Different sizes of clamps were made to best accommodate the various sizes of upper and lower access limbs. An initial clinical study on 25 patients conducted by the dialysis nurses at the University of Alabama at Birmingham and Sylacauga dialysis center, Sylacaga, Alabama demonstrated no problems with the C clamp system.
{"title":"A new hemostasis device for hemodialysis patients","authors":"J.R. Tamarapalli, J. Lemons, J. Dockery, B. Burdick","doi":"10.1109/SBEC.1995.514507","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514507","url":null,"abstract":"The major main aims of the study were to: 1. develop a device to obtain a better result compared to manual puncture site compression; 2. develop a stable device which would not slip during application; 3. help all dialysis patients, especially those patients who are unable to hold their needle puncture sites; 4. relieve the nurse to attend to other activities; and 5. to better utilize the whole length of the graft thereby preventing recirculation of non-dialysis blood and repeatedly puncturing a short length of the graft. A device was fabricated from a light weight plastic material with a C shape. This contour allowed conformity to the various shapes of the dialysis access limbs. The device included a rotatable threaded shaft, with which it was possible to achieve a controlled pressure on the fistula or graft. An internal (shaft) safety mechanism was incorporated so that undue pressure could not be applied on the vascular graft. The device was designed to be stable and comfortable. The puncture site contact surface of the device was designed to be disposable and to minimize any possibilities of cross contamination. Different sizes of clamps were made to best accommodate the various sizes of upper and lower access limbs. An initial clinical study on 25 patients conducted by the dialysis nurses at the University of Alabama at Birmingham and Sylacauga dialysis center, Sylacaga, Alabama demonstrated no problems with the C clamp system.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131287240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514495
E. Walsh, A. Schettini
Intracranial pressure (ICP) monitoring of cerebrospinal fluid (CSF) dynamics is used in the management of neurological conditions associated with intracranial hypertension. An extension of this is the measurement of the system pressure-volume index (PVI) which is intended to provide an indication of the intracranial buffering capacity, used in predicting the change in ICP when the craniospinal system is subject to further volume increments. Alternative means of identifying the intracranial buffering capacity involve the determination of the system compliance (C) or the volume-pressure response (VPR). Here, the authors contrast these measurements in the case of controlled intracranial mass expansion and, further, relate the determination of brain tissue response derived from these measurements to a more direct method of measuring brain tissue properties.
{"title":"Measurement of the intracranial buffering capacity of the cerebrospinal fluid system","authors":"E. Walsh, A. Schettini","doi":"10.1109/SBEC.1995.514495","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514495","url":null,"abstract":"Intracranial pressure (ICP) monitoring of cerebrospinal fluid (CSF) dynamics is used in the management of neurological conditions associated with intracranial hypertension. An extension of this is the measurement of the system pressure-volume index (PVI) which is intended to provide an indication of the intracranial buffering capacity, used in predicting the change in ICP when the craniospinal system is subject to further volume increments. Alternative means of identifying the intracranial buffering capacity involve the determination of the system compliance (C) or the volume-pressure response (VPR). Here, the authors contrast these measurements in the case of controlled intracranial mass expansion and, further, relate the determination of brain tissue response derived from these measurements to a more direct method of measuring brain tissue properties.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127570153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514489
M. E. Harrow, S. M. David, R. Peindl, S. Frick, J. Kellam
Twelve matched pairs of fresh frozen human cadaveric femurs were tested in axial and torsional loading followed by implantation of an intramedullary nail or a 95/spl deg/ angled plate. An equal number of screws were used above the fracture, in either a grouped or dispersed configuration. Each femur was then tested with progressively more severe simulated fracture patterns. The plate with the dispersed screw configuration had the greatest torsional stiffness (p<0.0001). No significant difference was found in axial or torsional stiffness for nail or plate groups when analysing by increasing fracture severity.
{"title":"Comparative biomechanical analysis of supracondylar femur fracture fixation: locked intramedullary nail vs. 95/spl deg/ angled plate","authors":"M. E. Harrow, S. M. David, R. Peindl, S. Frick, J. Kellam","doi":"10.1109/SBEC.1995.514489","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514489","url":null,"abstract":"Twelve matched pairs of fresh frozen human cadaveric femurs were tested in axial and torsional loading followed by implantation of an intramedullary nail or a 95/spl deg/ angled plate. An equal number of screws were used above the fracture, in either a grouped or dispersed configuration. Each femur was then tested with progressively more severe simulated fracture patterns. The plate with the dispersed screw configuration had the greatest torsional stiffness (p<0.0001). No significant difference was found in axial or torsional stiffness for nail or plate groups when analysing by increasing fracture severity.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127715160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514442
V. Van Stee, J. Tortal, P.A. Williams, S. Saha
Many people suffer from temporomadibular joint (TMJ) pain and need treatment. However, the outcome of such physical therapy is often not evaluated objectively. The range of motion of the jaw could be used as an objective criterion for monitoring the effect of therapy for such patients. In this study the authors designed and manufactured such a device to measure the three dimensional motion of the jaw for human patients.
{"title":"A mechanical device to measure the three dimensional motion of the human jaw","authors":"V. Van Stee, J. Tortal, P.A. Williams, S. Saha","doi":"10.1109/SBEC.1995.514442","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514442","url":null,"abstract":"Many people suffer from temporomadibular joint (TMJ) pain and need treatment. However, the outcome of such physical therapy is often not evaluated objectively. The range of motion of the jaw could be used as an objective criterion for monitoring the effect of therapy for such patients. In this study the authors designed and manufactured such a device to measure the three dimensional motion of the jaw for human patients.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134067144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514437
O. Hall, M. Jahan
A thermoluminescence (TL) technique, which is simple but fast and sensitive, was used as a diagnostic tool to test short-term or initial (immediately following sterilization) oxidation of UHMWPE. More than 50% radical species decayed or oxidized in the first 10 min in an oxygen environment and in 25 min in a nitrogen environment. The glow-peak temperatures 130/spl deg/C and 160/spl deg/C of the TL glow curve were also found to be associated with the sterilization conditions, nitrogen and oxygen, respectively.
{"title":"Sterilization condition of UHMWPE is measured by thermoluminescence technique","authors":"O. Hall, M. Jahan","doi":"10.1109/SBEC.1995.514437","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514437","url":null,"abstract":"A thermoluminescence (TL) technique, which is simple but fast and sensitive, was used as a diagnostic tool to test short-term or initial (immediately following sterilization) oxidation of UHMWPE. More than 50% radical species decayed or oxidized in the first 10 min in an oxygen environment and in 25 min in a nitrogen environment. The glow-peak temperatures 130/spl deg/C and 160/spl deg/C of the TL glow curve were also found to be associated with the sterilization conditions, nitrogen and oxygen, respectively.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115876678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514485
J. Vossoughi, T. Caperna
Summary form only given. In experiments dealing with mechanical characterization of biological tissues, for simplicity, the tests are usually conducted at room temperature. The validity of this practice, however, is often questioned by researchers in physiology and medicine. The purpose of the present study was to investigate the effect of test temperature on the value of the residual strain of aortic rings. Aortas from three pigs (150 kg and 6 months old) extending from the root of descending aorta to the bifurcation were used. Using a total of 240 rings from aortas of three pigs, we have found no difference in the value of residual strain at various temperatures. It is, therefore, concluded that for simplicity, residual strain measurement can be conducted at room temperature.
{"title":"Effect of test temperature on vascular residual strain","authors":"J. Vossoughi, T. Caperna","doi":"10.1109/SBEC.1995.514485","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514485","url":null,"abstract":"Summary form only given. In experiments dealing with mechanical characterization of biological tissues, for simplicity, the tests are usually conducted at room temperature. The validity of this practice, however, is often questioned by researchers in physiology and medicine. The purpose of the present study was to investigate the effect of test temperature on the value of the residual strain of aortic rings. Aortas from three pigs (150 kg and 6 months old) extending from the root of descending aorta to the bifurcation were used. Using a total of 240 rings from aortas of three pigs, we have found no difference in the value of residual strain at various temperatures. It is, therefore, concluded that for simplicity, residual strain measurement can be conducted at room temperature.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"49 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123635499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514426
J. Wittenberg, B. Smith, R. N. Kruse, D. P. Mukherjee
The treatment of mandibular angle fractures is plagued with the highest postsurgical complication rate of all mandibular fractures. Multiple plating systems are available. In this study four plating variations were compared in a biomechanical in vitro study. All plating systems were noncompressive Synthes titanium plates. The 3.0 mm reconstruction plate with 6 holes, the 2 mm universal fracture plate with 6 and 8 holes and tension bands and the 6 hole universal fracture plate without tension band were compared. Measurements of gaps at the osteotomy sites showed no significant difference for the plating systems. However the vertical (inferior/superior) displacements were significantly higher for the six-hole plate without tension. The horizontal (bucca/lingual) displacement for the six-hole plate without tension had also highest displacement value. The addition of a tension band was effective to reduce these displacement values. Quantitative computed tomography scans were used to demonstrate a minimal difference in bone quality.
{"title":"Biomechanical evaluation of fixation devices for mandibular angle fractures","authors":"J. Wittenberg, B. Smith, R. N. Kruse, D. P. Mukherjee","doi":"10.1109/SBEC.1995.514426","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514426","url":null,"abstract":"The treatment of mandibular angle fractures is plagued with the highest postsurgical complication rate of all mandibular fractures. Multiple plating systems are available. In this study four plating variations were compared in a biomechanical in vitro study. All plating systems were noncompressive Synthes titanium plates. The 3.0 mm reconstruction plate with 6 holes, the 2 mm universal fracture plate with 6 and 8 holes and tension bands and the 6 hole universal fracture plate without tension band were compared. Measurements of gaps at the osteotomy sites showed no significant difference for the plating systems. However the vertical (inferior/superior) displacements were significantly higher for the six-hole plate without tension. The horizontal (bucca/lingual) displacement for the six-hole plate without tension had also highest displacement value. The addition of a tension band was effective to reduce these displacement values. Quantitative computed tomography scans were used to demonstrate a minimal difference in bone quality.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"297 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122008785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514415
C.E. Lopez-Reyna, R. Bagla, K.M. Lombard, J. Saunders
Over 60 million Americans suffer from "ringing-in-the-ears" or tinnitus. This disorder ranges from mildly annoying to debilitating, and at the moment there is no known effective medical treatment. Acoustic masking of the subjective tinnitus sound does provide a measure a relief for many patients. A narrow band masking device that is tunable and potentially portable is described in this report.
{"title":"The development of a masking device for tinnitus patients","authors":"C.E. Lopez-Reyna, R. Bagla, K.M. Lombard, J. Saunders","doi":"10.1109/SBEC.1995.514415","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514415","url":null,"abstract":"Over 60 million Americans suffer from \"ringing-in-the-ears\" or tinnitus. This disorder ranges from mildly annoying to debilitating, and at the moment there is no known effective medical treatment. Acoustic masking of the subjective tinnitus sound does provide a measure a relief for many patients. A narrow band masking device that is tunable and potentially portable is described in this report.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121605872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-04-07DOI: 10.1109/SBEC.1995.514453
A. Longo, B. Mehling, P. Barre, D. Snead, A. Taylor, D. Reynolds, P. K. Bajpai
The objective of this investigation was to develop a resorbable zinc calcium phosphorous ceramic oxide (ZCAP) organic acid-vitamin E composite containing an antibiotic for orthopedic and/or dental application, including nearly all cases of trauma of hard tissues. A composite consisting of 3.0 g ZCAP, 1.2 g malic acid, 0.6 g Ca(OH)/sub 2/, 9.6 mg gentamicin sulfate and 20 pl of vitamin E oil was compressed in a 5/16" die into 0.1 g pellets at a load of 2000 lbs in a hydraulic press. The right femur of experimental animals was accessed by routine surgical procedures. A mid-diaphyseal fracture was created under direct vision using a surgical bone saw. A 0.62 threaded K-wire was inserted into the intramedullary canal and retrograded through the knee using a drill. The implant was placed between the two ends of the fracture and the K-wire antegraded through the pellet into the proximal end of the femur and tested to assure good fixation. The K-wire protruding from the bone was cut flush with the end of the bone using wire cutters. The surgical site was closed using routine surgical procedures. Post surgery, each rat showed normal movement during the ten week experimental period. Gross morphological examination of euthanized animals showed filling of the defect. Radiographic examination of the bones showed resorption of the composite, evidence of bone healing and cancellous bone ingrowth. However, the new bone ingrowth appeared less dense than the cortical bone on either side of the defect. The data collected to date suggest that ZCAP composites can be used as osteoconductive fillers between two fractured ends of a bone.
本研究的目的是开发一种含有抗生素的可吸收锌钙磷陶瓷氧化物(ZCAP)有机酸-维生素E复合材料，用于骨科和/或牙科应用，包括几乎所有硬组织创伤病例。由3.0 g ZCAP, 1.2 g苹果酸，0.6 g Ca(OH)/sub 2/， 9.6 mg硫酸庆大霉素和20 pl维生素E油组成的复合材料在5/16"模具中压缩成0.1 g颗粒，在液压机中负载2000磅。实验动物的右股骨采用常规手术方法。在直视下使用外科骨锯造成中骨干骨折。将一根0.62螺纹的k针插入髓内管，用钻头逆行穿过膝关节。植入物放置在骨折两端之间，k线通过颗粒顺行进入股骨近端，并进行测试以确保良好的固定。用钢丝钳将从骨头中伸出的k形钢丝与骨头的末端切平。采用常规手术程序关闭手术部位。术后10周实验期内，各组大鼠运动正常。安乐死动物的大体形态学检查显示缺损填充。骨骼的x线检查显示复合材料的吸收，骨愈合和松质骨长入的证据。然而，新骨长入比缺损两侧的皮质骨密度小。迄今为止收集的数据表明，ZCAP复合材料可以用作骨骨折两端之间的骨传导填料。
{"title":"A zinc calcium phosphorous oxide ceramic and malic acid-Ca(OH)/sub 2/-vitamin E composite for repairing bone defects","authors":"A. Longo, B. Mehling, P. Barre, D. Snead, A. Taylor, D. Reynolds, P. K. Bajpai","doi":"10.1109/SBEC.1995.514453","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514453","url":null,"abstract":"The objective of this investigation was to develop a resorbable zinc calcium phosphorous ceramic oxide (ZCAP) organic acid-vitamin E composite containing an antibiotic for orthopedic and/or dental application, including nearly all cases of trauma of hard tissues. A composite consisting of 3.0 g ZCAP, 1.2 g malic acid, 0.6 g Ca(OH)/sub 2/, 9.6 mg gentamicin sulfate and 20 pl of vitamin E oil was compressed in a 5/16\" die into 0.1 g pellets at a load of 2000 lbs in a hydraulic press. The right femur of experimental animals was accessed by routine surgical procedures. A mid-diaphyseal fracture was created under direct vision using a surgical bone saw. A 0.62 threaded K-wire was inserted into the intramedullary canal and retrograded through the knee using a drill. The implant was placed between the two ends of the fracture and the K-wire antegraded through the pellet into the proximal end of the femur and tested to assure good fixation. The K-wire protruding from the bone was cut flush with the end of the bone using wire cutters. The surgical site was closed using routine surgical procedures. Post surgery, each rat showed normal movement during the ten week experimental period. Gross morphological examination of euthanized animals showed filling of the defect. Radiographic examination of the bones showed resorption of the composite, evidence of bone healing and cancellous bone ingrowth. However, the new bone ingrowth appeared less dense than the cortical bone on either side of the defect. The data collected to date suggest that ZCAP composites can be used as osteoconductive fillers between two fractured ends of a bone.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127240743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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