Lithium-ion batteries (LIBs) are the primary energy storage in electric vehicles. Their electrochemical performance, safety margin, and lifetime are highly temperature-dependent, with thermal non-uniformity accelerating aging and increasing the likelihood of thermal runaway. Single-phase immersion cooling (SPIC) has emerged as a promising approach for battery thermal management, owing to its high convective heat transfer capability and reduced thermal resistance. In this study, the thermal-hydraulic performance of a 21,700 LIB battery pack with a 5S7P configuration under SPIC is systematically investigated, considering multiple battery arrangements, inlet-outlet flow configurations, baffle structures, coolant types, and mass flow rates. The novelty of this work lies in the integrated, multi-parameter optimization of SPIC at a realistic and scalable battery pack level, combining battery arrangement, flow routing, baffle design, and coolant selection within a unified electrochemical-thermal framework. Battery parameters for the Newman-Tiedemann-Gu-Kim (NTGK) model are obtained experimentally under various discharge rates and coupled with a three-dimensional thermal model in ANSYS Fluent. The numerical results are validated against experimental data, with a maximum deviation of less than 5%. The optimal configuration, featuring a cross battery arrangement with one inlet on the left and two outlets in the middle and right flow configurations, and a perforated baffle, achieves a lowest maximum temperature (Tmax) of 30.05 °C and a temperature difference (ΔT) of 4.34 °C. Among the tested coolants, Pitherm 150B demonstrates superior overall performance, maintaining the battery pack within an optimal operating range with Tmax and ΔT at 29.46 °C and 3.83 °C, respectively, at a 2.0C discharge rate. These findings provide practical design guidance for developing efficient, scalable, and energy-efficient SPIC-based battery thermal management systems for electric vehicle and energy storage applications.
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