Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-01
O. S. Pershenkova, E. I. Mikhailova
Alcohol is a toxic substance that is associated with a spectrum of liver damage, including simple steatosis or fatty- degeneration of liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease (ALD) is the general term used for this spectrum of alcohol-related liver damage. Excessive or harmful alcohol use is among the top five risk factors for death and disability worldwide, causing 2.5 million deaths and 69.4 million annual disability-adjusted life years. The diagnosis of ABP can usually be made on the basis of anamnesis, clinical and laboratory findings. However, the diagnosis of ABP can be clinically challenging because there is no a single diagnostic test to confirm the diagnosis, and patients may not report the extent of their alcohol use.
{"title":"Diagnostic stigmas of alcoholic liver disease","authors":"O. S. Pershenkova, E. I. Mikhailova","doi":"10.51523/2708-6011.2023-20-2-01","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-01","url":null,"abstract":"Alcohol is a toxic substance that is associated with a spectrum of liver damage, including simple steatosis or fatty- degeneration of liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease (ALD) is the general term used for this spectrum of alcohol-related liver damage. Excessive or harmful alcohol use is among the top five risk factors for death and disability worldwide, causing 2.5 million deaths and 69.4 million annual disability-adjusted life years. The diagnosis of ABP can usually be made on the basis of anamnesis, clinical and laboratory findings. However, the diagnosis of ABP can be clinically challenging because there is no a single diagnostic test to confirm the diagnosis, and patients may not report the extent of their alcohol use.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122128551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-13
T. Sharshakova, N. Hayashida, J. Takahashi, A. Sachkouskaya
Objective. The purpose of the study was to conduct a cross-cultural analysis of the quality of life of medical workers in Belarus and Japan, to assess the similarities and differences, to identify cultural characteristics and factors affecting the quality of life of medical workers of both countries.Materials and methods. The study was conducted in medical organizations in Gomel, Belarus, where 400 respondents (doctors and nurses) were interviewed and in university clinics in Nagasaki (Japan), where 238 medical workers took part in the survey. The survey was conducted using a validated Russian and English versions of the WHO Brief Questionnaire for Quality of Life (WHOQOL-BREF).Results. The results of the study showed that Japanese medical workers are less satisfied with their ability to work and the ability to perform their duties compared to Belarusian medical workers (31.0 and 34.0% of respondents in Japan and 68.9 and 62.2% of respondents in Belarus, respectively, p < 0.001). About a third of respondents (31.6% in Belarus, 38.0% in Japan) often experience negative emotions (bad mood, anxiety, despair, depression). 79.0% of respondents in Belarus are satisfied with their personal relationships, while in Japan this indicator was 49.3% (p < 0.001). The percentage of dissatisfaction with their sex life is high among Japanese medical workers (71.9% compared to 21.8% of respondents in Belarus, p < 0.001). 56.6% of Japanese medical workers and 77.2% of Belarusian medical workers are satisfied with the support from friends (p < 0.001). Indicators of psychological health and social relations are higher among respondents who are married. The incidence of medical workers in both countries is very high: from 20 to 30% of respondents report the presence of a disease or health problem.Conclusion. Medical workers’ assessment of their quality of life depends largely on the different ways of life in the two countries, the peculiarities of the health care system, the general standard of living of the population, and other factors. However, as the survey showed, statistically these differences in the assessment of the quality of life are insignificant.
{"title":"Comparative study of the quality of life of medical workers in Belarus and Japan","authors":"T. Sharshakova, N. Hayashida, J. Takahashi, A. Sachkouskaya","doi":"10.51523/2708-6011.2023-20-2-13","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-13","url":null,"abstract":"Objective. The purpose of the study was to conduct a cross-cultural analysis of the quality of life of medical workers in Belarus and Japan, to assess the similarities and differences, to identify cultural characteristics and factors affecting the quality of life of medical workers of both countries.Materials and methods. The study was conducted in medical organizations in Gomel, Belarus, where 400 respondents (doctors and nurses) were interviewed and in university clinics in Nagasaki (Japan), where 238 medical workers took part in the survey. The survey was conducted using a validated Russian and English versions of the WHO Brief Questionnaire for Quality of Life (WHOQOL-BREF).Results. The results of the study showed that Japanese medical workers are less satisfied with their ability to work and the ability to perform their duties compared to Belarusian medical workers (31.0 and 34.0% of respondents in Japan and 68.9 and 62.2% of respondents in Belarus, respectively, p < 0.001). About a third of respondents (31.6% in Belarus, 38.0% in Japan) often experience negative emotions (bad mood, anxiety, despair, depression). 79.0% of respondents in Belarus are satisfied with their personal relationships, while in Japan this indicator was 49.3% (p < 0.001). The percentage of dissatisfaction with their sex life is high among Japanese medical workers (71.9% compared to 21.8% of respondents in Belarus, p < 0.001). 56.6% of Japanese medical workers and 77.2% of Belarusian medical workers are satisfied with the support from friends (p < 0.001). Indicators of psychological health and social relations are higher among respondents who are married. The incidence of medical workers in both countries is very high: from 20 to 30% of respondents report the presence of a disease or health problem.Conclusion. Medical workers’ assessment of their quality of life depends largely on the different ways of life in the two countries, the peculiarities of the health care system, the general standard of living of the population, and other factors. However, as the survey showed, statistically these differences in the assessment of the quality of life are insignificant.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124733357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-07
N. A. Nikulina, E. A. Akulova, E. Dotsenko, N. B. Krivelevich, S. G. Seifidinova, A. A. Kovalev, D. D. Zinkevich, D. A. Ponomarenko, S. P. Tishkov, A. N. Kavalchuk, Yu. V. Repina
Objective. To identify the features of transient hyperglycemia in dynamics in acute coronary heart disease in patients without impaired glycemic metabolism.Materials and methods. We performed a retrospective analysis of 178 medical records of inpatients with acute forms of coronary heart disease: transmural myocardial infarction (MI), subendocardial MI, unstable angina - initially urgently hospitalized and further treated in the institution “Gomel Regional Clinical Cardiology Center” in 2021-2022. All the patients were examined and treated in accordance with the clinical protocol for the diagnosis and treatment of diseases of the circulatory system [1]. Venous blood glucose level in dynamics was measured at hospitalization during the first hours of the disease not on an empty stomach and then on an empty stomach on the 1st, 2nd, 3rd, 4th and 5th day; according to EchoCG data on the 1st-3rd day included the ejection fraction (EF) and local contractility index (LCI). The patients were divided into groups depending on the disease, blood glucose level at hospital admission (not requiring pharmacological correction 4.1–10.9 mmol/l, requiring pharmacological correction 11 mmol/l and more [1]) and the presence/absence of a rise in blood glucose levels on the first day of hospitalization (the 1st day of the diseases).Results. Transient hyperglycemia in acute forms of coronary heart disease in patients without impaired glycemic metabolism is most evident with transmural MI, hyperglycemia of more than 11.0 mmol / l occurs in 7% of cases of all transmural MI, of which 28.5% persists on the 1st day, which requires continued pharmacological correction. Relative normalization of glucose at initial glucose values up to 11 mmol/l occurs on the 2nd day, with a tendency in transmural myocardial infarction and glucose levels over 11 mmol/l - on the 3rd day, of MI and an episode of glucose level rise in dynamics — on the 4th day of MI. Transient hyperglycemia with subendocardial MI and unstable angina is not characterized by an increase in glucose more than 11.0 mmol/l, with relative normalization on the 2nd day, while higher glucose levels are observed at admission compared to those with unstable angina.Conclusion. Transient hyperglycemia over 11 mmol/l in transmural MI in patients without glycemic metabolism disorders in 28.5% of cases remains on the 1st day of MI, which requires continued medication correction of hyperglycemia. Subendocardial MI and unstable angina are not characterized by the occurrence of transient hyperglycemia, requiring pharmacological correction, with relative normalization of the index by 2nd day.
{"title":"Transient hyperglycemia in acute coronary heart disease","authors":"N. A. Nikulina, E. A. Akulova, E. Dotsenko, N. B. Krivelevich, S. G. Seifidinova, A. A. Kovalev, D. D. Zinkevich, D. A. Ponomarenko, S. P. Tishkov, A. N. Kavalchuk, Yu. V. Repina","doi":"10.51523/2708-6011.2023-20-2-07","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-07","url":null,"abstract":"Objective. To identify the features of transient hyperglycemia in dynamics in acute coronary heart disease in patients without impaired glycemic metabolism.Materials and methods. We performed a retrospective analysis of 178 medical records of inpatients with acute forms of coronary heart disease: transmural myocardial infarction (MI), subendocardial MI, unstable angina - initially urgently hospitalized and further treated in the institution “Gomel Regional Clinical Cardiology Center” in 2021-2022. All the patients were examined and treated in accordance with the clinical protocol for the diagnosis and treatment of diseases of the circulatory system [1]. Venous blood glucose level in dynamics was measured at hospitalization during the first hours of the disease not on an empty stomach and then on an empty stomach on the 1st, 2nd, 3rd, 4th and 5th day; according to EchoCG data on the 1st-3rd day included the ejection fraction (EF) and local contractility index (LCI). The patients were divided into groups depending on the disease, blood glucose level at hospital admission (not requiring pharmacological correction 4.1–10.9 mmol/l, requiring pharmacological correction 11 mmol/l and more [1]) and the presence/absence of a rise in blood glucose levels on the first day of hospitalization (the 1st day of the diseases).Results. Transient hyperglycemia in acute forms of coronary heart disease in patients without impaired glycemic metabolism is most evident with transmural MI, hyperglycemia of more than 11.0 mmol / l occurs in 7% of cases of all transmural MI, of which 28.5% persists on the 1st day, which requires continued pharmacological correction. Relative normalization of glucose at initial glucose values up to 11 mmol/l occurs on the 2nd day, with a tendency in transmural myocardial infarction and glucose levels over 11 mmol/l - on the 3rd day, of MI and an episode of glucose level rise in dynamics — on the 4th day of MI. Transient hyperglycemia with subendocardial MI and unstable angina is not characterized by an increase in glucose more than 11.0 mmol/l, with relative normalization on the 2nd day, while higher glucose levels are observed at admission compared to those with unstable angina.Conclusion. Transient hyperglycemia over 11 mmol/l in transmural MI in patients without glycemic metabolism disorders in 28.5% of cases remains on the 1st day of MI, which requires continued medication correction of hyperglycemia. Subendocardial MI and unstable angina are not characterized by the occurrence of transient hyperglycemia, requiring pharmacological correction, with relative normalization of the index by 2nd day.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123029126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-15
D. Cherednichenko
Objective. Define the concept of “informed voluntary consent”. To develop ethical recommendations and legal standards for the registration of consent and refusal of the patient in relation to medical intervention.Materials and methods. To achieve this goal, we conducted a content analysis of domestic and foreign literature, as well as regulatory legal acts of the Republic of Belarus devoted to this issue.Results. The definition of the concept of “informed voluntary consent” is given. Ethical recommendations and legal standards for the registration of the patient’s consent and refusal regarding medical intervention have been developed.Conclusion. Compliance by medical professionals with ethical recommendations and legal standards will significantly mitigate the risks of conflict situations and avoid their consequences.
{"title":"Ethical recommendations and legal standards for the registration of consent and refusal of the patient in relation to medical intervention","authors":"D. Cherednichenko","doi":"10.51523/2708-6011.2023-20-2-15","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-15","url":null,"abstract":"Objective. Define the concept of “informed voluntary consent”. To develop ethical recommendations and legal standards for the registration of consent and refusal of the patient in relation to medical intervention.Materials and methods. To achieve this goal, we conducted a content analysis of domestic and foreign literature, as well as regulatory legal acts of the Republic of Belarus devoted to this issue.Results. The definition of the concept of “informed voluntary consent” is given. Ethical recommendations and legal standards for the registration of the patient’s consent and refusal regarding medical intervention have been developed.Conclusion. Compliance by medical professionals with ethical recommendations and legal standards will significantly mitigate the risks of conflict situations and avoid their consequences.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"5 3-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132027340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-03
Y. A. Lyzikova, M. V. Smirnova
Objective. To measure leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes.Materials and methods. 90 patients were included in the study, 70 with hyperplastic endometrial processes made up the main group, 20 with morphologically normal endometrium were included in the comparison group. The concentration of leptin and the soluble leptin receptor in the blood serum was measured by the method of enzyme immunoassay, the clinical and anamnestic characteristics of the disease were studied Results. There were no significant differences between the groups when comparing serum leptin levels: in the study group, the hormone level was 6,01 (3,64;7,50) ng/ml, in the comparison group — 6,44 (3,55;10,11) ng/ml (z = 0,61, p = 0,54). The level of soluble leptin receptor was significantly lower in patients in the main group and was 8531 (5697; 15895) ng/ml, and 16181 (10696; 20251) ng/ml in the comparison group (z = 2.614, p = 0.008).Conclusion. Patients with endometrial hyperplastic processes are characterized by a decreased level of the soluble leptin receptor, whereas a leptin level has no significant differences compared to those in patients without endometrial pathology. The identified condition causes a defect in the signal transmission from the leptin receptor and a decrease in the hormone transport, leading to a disruption of the biological action of leptin. The established level of soluble leptin receptor < 14769 pg/ml, in combination with ultrasound examination, will increase the efficiency of diagnostic measures to detect endometrial hyperplastic processes.
目标。测量子宫内膜增生性病变患者的瘦素和可溶性瘦素受体水平。材料和方法。本研究共纳入90例患者，其中子宫内膜增生性病变70例为主要组，子宫内膜形态正常的20例为对照组。采用酶免疫分析法测定血清中瘦素和可溶性瘦素受体的浓度，研究该病的临床和记忆特征。两组间血清瘦素水平比较无显著差异:研究组血清清瘦素水平为6,01 (3,64;7,50)ng/ml，对照组为- 6,44 (3,55;10,11)ng/ml (z = 0,61, p = 0,54)。主组患者可溶性瘦素受体水平明显降低，为8531 (5697;15895) ng/ml, 16181 (10696;p = 0.008, p = 2.614。子宫内膜增生过程患者的特点是可溶性瘦素受体水平降低，而与没有子宫内膜病理的患者相比，瘦素水平没有显著差异。确定的条件导致瘦素受体的信号传递缺陷和激素运输减少，导致瘦素的生物作用中断。确定可溶性瘦素受体< 14769 pg/ml，结合超声检查，可提高诊断措施检测子宫内膜增生过程的效率。
{"title":"Measurement of leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes","authors":"Y. A. Lyzikova, M. V. Smirnova","doi":"10.51523/2708-6011.2023-20-2-03","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-03","url":null,"abstract":"Objective. To measure leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes.Materials and methods. 90 patients were included in the study, 70 with hyperplastic endometrial processes made up the main group, 20 with morphologically normal endometrium were included in the comparison group. The concentration of leptin and the soluble leptin receptor in the blood serum was measured by the method of enzyme immunoassay, the clinical and anamnestic characteristics of the disease were studied Results. There were no significant differences between the groups when comparing serum leptin levels: in the study group, the hormone level was 6,01 (3,64;7,50) ng/ml, in the comparison group — 6,44 (3,55;10,11) ng/ml (z = 0,61, p = 0,54). The level of soluble leptin receptor was significantly lower in patients in the main group and was 8531 (5697; 15895) ng/ml, and 16181 (10696; 20251) ng/ml in the comparison group (z = 2.614, p = 0.008).Conclusion. Patients with endometrial hyperplastic processes are characterized by a decreased level of the soluble leptin receptor, whereas a leptin level has no significant differences compared to those in patients without endometrial pathology. The identified condition causes a defect in the signal transmission from the leptin receptor and a decrease in the hormone transport, leading to a disruption of the biological action of leptin. The established level of soluble leptin receptor < 14769 pg/ml, in combination with ultrasound examination, will increase the efficiency of diagnostic measures to detect endometrial hyperplastic processes.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115706525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-02
A. Dyatlov, I. V. Mikhailov, V. A. Kudrashou
Objective. To analyze and systematize data on the use of neoadjuvant chemotherapy in the complex treatment of stomach cancer.Materials and methods. The original publications containing information on the use of neoadjuvant chemotherapy in the complex treatment of gastric cancer deposited in the resources of PubMed and the information portal eLIBRARY.RU have been studied.Results. The most important aspects concerning the use of neoadjuvant polychemotherapy in the complex treatment of gastric cancer have been outlined.Conclusion. According to the available literature data, the use of neoadjuvant chemotherapy can serve as an important factor in preventing the progression of the tumor process due to the impact on undetected micrometastases, but many aspects are not covered sufficiently in scientific publications. Therefore, the study of neoadjuvant chemotherapy in the complex treatment of gastric cancer, including D2 lymphodissection, is currently very relevant.
{"title":"Neoadjuvant polychemotherapy in the complex treatment of gastric cancer","authors":"A. Dyatlov, I. V. Mikhailov, V. A. Kudrashou","doi":"10.51523/2708-6011.2023-20-2-02","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-02","url":null,"abstract":"Objective. To analyze and systematize data on the use of neoadjuvant chemotherapy in the complex treatment of stomach cancer.Materials and methods. The original publications containing information on the use of neoadjuvant chemotherapy in the complex treatment of gastric cancer deposited in the resources of PubMed and the information portal eLIBRARY.RU have been studied.Results. The most important aspects concerning the use of neoadjuvant polychemotherapy in the complex treatment of gastric cancer have been outlined.Conclusion. According to the available literature data, the use of neoadjuvant chemotherapy can serve as an important factor in preventing the progression of the tumor process due to the impact on undetected micrometastases, but many aspects are not covered sufficiently in scientific publications. Therefore, the study of neoadjuvant chemotherapy in the complex treatment of gastric cancer, including D2 lymphodissection, is currently very relevant.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121311975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-18
A. Yakovenko, K. L. Murashko, V. N. Belyakovsky, E. Yakovenko
Objective. To present a clinical case of diagnosis and surgical treatment of one of the forms of extragenital endometriosis – umbilical ring endometriosis.Materials and methods. A clinical case of patient M., 33 years old, female, with diagnosed and operated endometrial heterotopia in the projection of the soft tissues of the umbilical region.Results. The probable role of the migration theory of the pathogenesis of endometriosis is demonstrated due to the lack of a history of surgical treatment in this area.Conclusion. The migration theory of the pathogenesis of endometriosis can be explained by the mechanism of retrograde penetration of endometrial cells through blood and/or lymphatic vessels from the pelvic cavity.
{"title":"Endometriosis of the umbilical ring","authors":"A. Yakovenko, K. L. Murashko, V. N. Belyakovsky, E. Yakovenko","doi":"10.51523/2708-6011.2023-20-2-18","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-18","url":null,"abstract":"Objective. To present a clinical case of diagnosis and surgical treatment of one of the forms of extragenital endometriosis – umbilical ring endometriosis.Materials and methods. A clinical case of patient M., 33 years old, female, with diagnosed and operated endometrial heterotopia in the projection of the soft tissues of the umbilical region.Results. The probable role of the migration theory of the pathogenesis of endometriosis is demonstrated due to the lack of a history of surgical treatment in this area.Conclusion. The migration theory of the pathogenesis of endometriosis can be explained by the mechanism of retrograde penetration of endometrial cells through blood and/or lymphatic vessels from the pelvic cavity.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125112450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-11
I. V. Nikolayeva, V. Sheibak, A. Astrowskaja, S. Astrautsova
Objective. To assess the condition of the microbial-tissue complex of the large intestine when hepatotoxic concentrations of acetaminophen are administrated to the body of animals.Materials and methods. The experiments were performed on 24 white outbred rats weighing 180–220 g, which were divided into three groups. The control group received 2% starch solution enterally, the first experimental group was enterally administered with acetaminophen in starch solution at a dose of 1500 mg per kilogram of body weight, five times a day with one day interval; and the second experimental group was administered with acetaminophen at a dose of 2500 mg per kilogram of body weight the same way. Free amino acids and their nitrogen-containing metabolites were determined by high-performance liquid chromatography in samples of the microbial-tissue complex (MTC) of the large intestine previously frozen at -70 °C. For microbiological study, the aseptically isolated MTC was immediately sent to a microbiological laboratory for identification of the content of the main representatives of the intestinal microflora. Samples of the wall of the ascending colon were subjected to histological and electron microscopic examination. The hepatotoxic effect of acetaminophen was evaluated by registering the activity of enzymes and the content of total bilirubin in blood plasma.Results. Enteral administration of hepatotoxic amounts of acetaminophen to rats increases the concentrations of free amino acids and their nitrogen-containing derivatives in the microbial-tissue complex of the large intestine. At the same time, the concentrations of essential amino acids are significantly increased. Morphological changes in the cells of the epithelium of the large intestine and the structure of mitochondria have been shown.Conclusions. Toxic doses of acetaminophen have a significant impact on the indicators of the microbial-tissue complex of the large intestine. There are changes in biochemical parameters of amino acid metabolism: increased levels of substitutable amino acids and changes in the colonocytes (size and shape of mitochondria, the height of the brush border, the volume of the goblet cells), indicating decreased ability of the cells to use amino acids to support the functioning of the Krebs cycle. This is also confirmed by significantly increased concentrations of essential amino acids, which are mainly used for protein synthesis. The dysbiosis caused by acetaminophen further contributes to the damage to the large intestine. The negative effect of acetaminophen is confirmed by the dose-dependent changes we found in the microbial-tissue complex.
{"title":"The effect of acetaminophen on the structural and functional state of the large intestine and intestinal microflora","authors":"I. V. Nikolayeva, V. Sheibak, A. Astrowskaja, S. Astrautsova","doi":"10.51523/2708-6011.2023-20-2-11","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-11","url":null,"abstract":"Objective. To assess the condition of the microbial-tissue complex of the large intestine when hepatotoxic concentrations of acetaminophen are administrated to the body of animals.Materials and methods. The experiments were performed on 24 white outbred rats weighing 180–220 g, which were divided into three groups. The control group received 2% starch solution enterally, the first experimental group was enterally administered with acetaminophen in starch solution at a dose of 1500 mg per kilogram of body weight, five times a day with one day interval; and the second experimental group was administered with acetaminophen at a dose of 2500 mg per kilogram of body weight the same way. Free amino acids and their nitrogen-containing metabolites were determined by high-performance liquid chromatography in samples of the microbial-tissue complex (MTC) of the large intestine previously frozen at -70 °C. For microbiological study, the aseptically isolated MTC was immediately sent to a microbiological laboratory for identification of the content of the main representatives of the intestinal microflora. Samples of the wall of the ascending colon were subjected to histological and electron microscopic examination. The hepatotoxic effect of acetaminophen was evaluated by registering the activity of enzymes and the content of total bilirubin in blood plasma.Results. Enteral administration of hepatotoxic amounts of acetaminophen to rats increases the concentrations of free amino acids and their nitrogen-containing derivatives in the microbial-tissue complex of the large intestine. At the same time, the concentrations of essential amino acids are significantly increased. Morphological changes in the cells of the epithelium of the large intestine and the structure of mitochondria have been shown.Conclusions. Toxic doses of acetaminophen have a significant impact on the indicators of the microbial-tissue complex of the large intestine. There are changes in biochemical parameters of amino acid metabolism: increased levels of substitutable amino acids and changes in the colonocytes (size and shape of mitochondria, the height of the brush border, the volume of the goblet cells), indicating decreased ability of the cells to use amino acids to support the functioning of the Krebs cycle. This is also confirmed by significantly increased concentrations of essential amino acids, which are mainly used for protein synthesis. The dysbiosis caused by acetaminophen further contributes to the damage to the large intestine. The negative effect of acetaminophen is confirmed by the dose-dependent changes we found in the microbial-tissue complex.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121427098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-09
A.-M. V. Yerofeyeva, E. V. Fedorova, S. Rjabceva, A. Molchanova
Objective. Compare the effectiveness of systemic and local administration of adipose-derived mesenchymal stem cells (ADMSC) at a dose of 1х106 cells/kg on nociceptive sensitivity to mechanical and thermal stimuli in rats and changes in histostructure of sciatic nerve and surrounded tissues of affected hind paw in experimental model of peripheral neuropathy of sciatic nerve.Materials and methods. 26 male Wistar rats were used to perform a model of peripheral neuropathy by axotomy of the sciatic nerve. On the 7th day, the experimental animals underwent systemic or local transplantation of ADMSC at a dose of 1x106 cells/kg. Nociceptive responses to mechanical and thermal stimuli were assessed for 90 days, and the histostructure of the sciatic nerve and surrounding tissues was analyzed after systemic and local transplantation of ADMSC.Results. Systemic administration of ADMSC at a dose of 1x106 cells/kg to rats with sciatic nerve axotomy increased the mechanical withdrawal threshold (MWT) by 17.1% and had no effect on the thermal withdrawal latency (TWL). Local administration of ADMSCs in an equivalent dose contributed to the full recovery of the MWT and TWL by the 21st day of the experiment, as well as suppressed the inflammatory reaction in the soft tissues of the operated hind paw of experimental animals.Conclusion. Intramuscular administration of ADMSC into the area of sciatic nerve axotomy of rats was significantly more effective than systemic administration of an equivalent dose of a cell transplant. This method of administration is more appropriate for further studies of the mechanisms of antinociceptive and reparative effects of ADMSCs.
{"title":"Comparative evaluation of the effectiveness of systemic and local administration of mesenchymal stem cells in experimental neuropathy","authors":"A.-M. V. Yerofeyeva, E. V. Fedorova, S. Rjabceva, A. Molchanova","doi":"10.51523/2708-6011.2023-20-2-09","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-09","url":null,"abstract":"Objective. Compare the effectiveness of systemic and local administration of adipose-derived mesenchymal stem cells (ADMSC) at a dose of 1х106 cells/kg on nociceptive sensitivity to mechanical and thermal stimuli in rats and changes in histostructure of sciatic nerve and surrounded tissues of affected hind paw in experimental model of peripheral neuropathy of sciatic nerve.Materials and methods. 26 male Wistar rats were used to perform a model of peripheral neuropathy by axotomy of the sciatic nerve. On the 7th day, the experimental animals underwent systemic or local transplantation of ADMSC at a dose of 1x106 cells/kg. Nociceptive responses to mechanical and thermal stimuli were assessed for 90 days, and the histostructure of the sciatic nerve and surrounding tissues was analyzed after systemic and local transplantation of ADMSC.Results. Systemic administration of ADMSC at a dose of 1x106 cells/kg to rats with sciatic nerve axotomy increased the mechanical withdrawal threshold (MWT) by 17.1% and had no effect on the thermal withdrawal latency (TWL). Local administration of ADMSCs in an equivalent dose contributed to the full recovery of the MWT and TWL by the 21st day of the experiment, as well as suppressed the inflammatory reaction in the soft tissues of the operated hind paw of experimental animals.Conclusion. Intramuscular administration of ADMSC into the area of sciatic nerve axotomy of rats was significantly more effective than systemic administration of an equivalent dose of a cell transplant. This method of administration is more appropriate for further studies of the mechanisms of antinociceptive and reparative effects of ADMSCs.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116088705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.51523/2708-6011.2023-20-2-17
O. Yarmolenko, E. G. Malaeva, I. L. Mamchenko, T. V. Aleynykova, L. A. Kobruseva, I. A. Khudyakov, M. N. Menshakova, E. I. Malasсhenko
Autoimmune liver disease is a heterogeneous group of diseases in which the body’s immune cells and antibodies are directed against its own components of the liver tissue. The main diseases from this group are: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis. Most often there are classical monovariants of the disease, but in some cases, manifestations of two forms from the autoimmune liver disease are observed at once. The term “overlap syndrome” is used to describe such conditions. The article presents a clinical case of a combination of PBC and AIH, one of the most common overlapping syndromes in practice. Most often there are classical monovariants of the disease, but in some cases there are manifestations of two forms of autoimmune liver diseases. Overlap syndrome is a term used to describe these conditions. This article presents a clinical case of a combination of PBC and AIH, one of the most common cross-linked syndromes in practice.
{"title":"Overlap syndrome in hepatology","authors":"O. Yarmolenko, E. G. Malaeva, I. L. Mamchenko, T. V. Aleynykova, L. A. Kobruseva, I. A. Khudyakov, M. N. Menshakova, E. I. Malasсhenko","doi":"10.51523/2708-6011.2023-20-2-17","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-2-17","url":null,"abstract":"Autoimmune liver disease is a heterogeneous group of diseases in which the body’s immune cells and antibodies are directed against its own components of the liver tissue. The main diseases from this group are: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis. Most often there are classical monovariants of the disease, but in some cases, manifestations of two forms from the autoimmune liver disease are observed at once. The term “overlap syndrome” is used to describe such conditions. The article presents a clinical case of a combination of PBC and AIH, one of the most common overlapping syndromes in practice. Most often there are classical monovariants of the disease, but in some cases there are manifestations of two forms of autoimmune liver diseases. Overlap syndrome is a term used to describe these conditions. This article presents a clinical case of a combination of PBC and AIH, one of the most common cross-linked syndromes in practice.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125273407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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